EuRBPDB

Microtus_ochrogasterFamily: tRNA_U5-meth_tr Number of Genes: 2

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
ENSMOCG00000002597	Trmt2a	101984356
ENSMOCG00000013806	Trmt2b	101995963

Introduction

Pfam

This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalysed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity [1].

InterPro

This family consists of (uracil-5-)-methyltransferases EC from bacteria, archaea and eukaryotes. They are class I-like SAM-binding methyltransferases.

Reference

Johansson MJ, Bystrom AS; , RNA 2002;8:324-335.: Dual function of the tRNA(m(5)U54)methyltransferase in tRNA maturation. PUBMED:12003492 EPMC:12003492.