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This is a family of tRNA (Guanine-1)-methyltransferases EC:184.108.40.206. In E.coli K12 this enzyme catalyses the conversion of a guanosine residue to N1-methylguanine in position 37, next to the anticodon, in tRNA .
This domain is found in tRNA methyltransferases including tRNA (guanine-N(1)-)-methyltransferases (TRMD) and mitochondrial ribonuclease P protein 1. Proteins containing this domain also include tRNA (guanine(9)-N1)-methyltransferase (Trm10) from yeasts.
Hjalmarsson KJ, Bystrom AS, Bjork GR; , J Biol Chem 1983;258:1343-1351.: Purification and characterization of transfer RNA (guanine- 1)methyltransferase from Escherichia coli. PUBMED:6337136 EPMC:6337136.