EuRBPDB

Mus_caroliFamily: z-alpha Number of Genes: 2

Ensembl ID	Symbol	Entrez ID	RBD	RBPome	PRI	Expresion	Pathway	Phenotype	Paralog	Ortholog	GO
MGP_CAROLIEiJ_G0024748	Zbp1	110285455
MGP_CAROLIEiJ_G0025215	Adar	110291799

Introduction

Pfam

This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance [1].

InterPro

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Reference

Schade M, Turner CJ, Kuhne R, Schmieder P, Lowenhaupt K, Herbert A, Rich A, Oschkinat H; , Proc Natl Acad Sci U S A 1999;96:12465-12470.: The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA. PUBMED:10535945 EPMC:10535945.