Aotus_nancymaaeFamily: zf-C2H2_jaz Number of Genes: 21
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
ZNF385A
NUFIP1
-
-
PRDM10
ZNF277
ZNF385B
ZNF638
ZMAT4
ZMAT2
DNAJC21
TRIT1
-
ZNF784
-
GPATCH8
ZNF804A
ZNF593
ZNF804B
ZMAT3
ZNF385C
ZNF385D
CIZ1

Introduction

Pfam

This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.

InterPro

This zinc finger is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus [PUBMED:10488071]. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.

Reference

  1. Yang M, May WS, Ito T;, J Biol Chem. 1999;274:27399-27406.: JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. PUBMED:10488071 EPMC:10488071.