Cercocebus_atysFamily: zf-C2H2_jaz Number of Genes: 19
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
NUFIP1
-
ZNF804A
ZNF804B
ZNF385B
ZMAT3
GPATCH8
DNAJC21
ZNF277
ZNF622
ZNF638
ZNF784
ZNF385D
TRIT1
CIZ1
ZNF385A
PRDM10
ZNF385C
ZMAT4

Introduction

Pfam

This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.

InterPro

This zinc finger is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus [PUBMED:10488071]. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.

Reference

  1. Yang M, May WS, Ito T;, J Biol Chem. 1999;274:27399-27406.: JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. PUBMED:10488071 EPMC:10488071.