Pan_paniscusFamily: zf-C2H2_jaz Number of Genes: 21
Ensembl IDSymbolEntrez IDRBD RBPome PRIExpresion PathwayPhenotype ParalogOrthologGO
TRIT1
ZNF426
NUFIP1
ZNF622
ZNF784
ZNF277
ZNF593
CIZ1
ZNF804B
ZMAT2
ZNF385A
ZMAT3
ZNF385B
ZNF638
ZNF385D
GPATCH8
ZNF804A
ZMAT4
DNAJC21
PRDM10
ZNF385C

Introduction

Pfam

This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.

InterPro

This zinc finger is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus [PUBMED:10488071]. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.

Reference

  1. Yang M, May WS, Ito T;, J Biol Chem. 1999;274:27399-27406.: JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. PUBMED:10488071 EPMC:10488071.