EuRBPDB

Cercocebus_atysFamily: zf-CCCH_2 Number of Genes: 7

Ensembl ID	Symbol	Entrez ID
ENSCATG00000012691	ZC3H10	105587310
ENSCATG00000026685	ZC3H14	105596546
ENSCATG00000031295	ZC3H8	105591136
ENSCATG00000036303	MBNL3	105586247
ENSCATG00000036595	ZC3H6	105591138
ENSCATG00000040406	MBNL2	105574468
ENSCATG00000041591	MKRN2	105585804

Introduction

Pfam

This is an unusual zinc-finger family, and is represented by fingers 5-7 of Nab2. Nab2 ZnF5-7 are zinc-fingers of the type C-x8-C-x5-C-x3-H. Nab2 ZnFs function in the generation of export-competent mRNPs. Mab2 is a conserved polyadenosine-RNA-binding Zn finger protein required for both mRNA export and polyadenylation regulation and becomes attached to the mRNP after splicing and during or immediately after polyadenylation. The three ZnFs, 5-7, have almost identical folds and, most unusually, associate with one another to form a single coherent structural unit. ZnF5-7 bind to eight consecutive adenines, and chemical shift perturbations identify residues on each finger that interact with RNA [1].

InterPro

No InterPro abstract

Reference

Brockmann C, Soucek S, Kuhlmann SI, Mills-Lujan K, Kelly SM, Yang JC, Iglesias N, Stutz F, Corbett AH, Neuhaus D, Stewart M;, Structure. 2012;20:1007-1018.: Structural basis for polyadenosine-RNA binding by Nab2 Zn fingers and its function in mRNA nuclear export. PUBMED:22560733 EPMC:22560733.