EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26782095	RNA-binding motif protein 5 inhibits the proliferation of cigarette smoke-transformed BEAS-2B cells through cell cycle arrest and apoptosis.	Oncol Rep	2016 Apr	Lv XJ	doi: 10.3892/or.2016.4551
28347247	Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer.	Tumour Biol	2017 Mar	Kobayashi T	doi: 10.1177/1010428317694547.
16546166	Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes.	Exp Cell Res	2006 Jun 10	Mourtada-Maarabouni M	-
18038152	Promoter methylation study of the H37/RBM5 tumor suppressor gene from the 3p21.3 human lung cancer tumor suppressor locus.	Hum Genet	2008 Feb	Oh JJ	-
20309933	p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.	Int J Cancer	2011 Jan 15	Kobayashi T	doi: 10.1002/ijc.25345
28662214	RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.	PLoS One	2017 Jun 29	Loiselle JJ	doi: 10.1371/journal.pone.0180258
16585163	3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis.	Cancer Res	2006 Apr 1	Oh JJ	-
22866867	The tumor suppressor gene RBM5 inhibits lung adenocarcinoma cell growth and induces apoptosis.	World J Surg Oncol	2012 Aug 6	Shao C	doi: 10.1186/1477-7819-10-160.
17606309	The two single nucleotide polymorphisms in the H37/RBM5 tumour suppressor gene at 3p21.3 correlated with different subtypes of non-small cell lung cancers.	Lung Cancer	2007 Oct	Oh JJ	-
27520449	RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells.	Cancer Res	2016 Oct 1	Di Cecilia S	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	50118350	Missense_Mutation	NA	G781A	0.1	zf-RanBP
BLCA	chr3	50100634	Intron	novel		0.49
BLCA	chr3	50117354	Frame_Shift_Ins	novel	*Q767Lfs14**	0.31	zf-RanBP
BLCA	chr3	50108098	Missense_Mutation	NA	D357G	0.43
BLCA	chr3	50107552	Nonsense_Mutation	novel	Q342*	0.16
BLCA	chr3	50117040	Intron	novel		0.27
BLCA	chr3	50113992	Nonsense_Mutation	novel	Q554*	0.49
BLCA	chr3	50115484	Missense_Mutation	novel	E632D	0.08
BLCA	chr3	50110756	Missense_Mutation	novel	D481Y	0.34
BLCA	chr3	50093719	Splice_Site	novel	X62_splice	0.37
BLCA	chr3	50107496	Missense_Mutation	NA	S323L	0.3
BLCA	chr3	50113511	Silent	novel	K528K	0.33
BRCA	chr3	50115497	Missense_Mutation	NA	E637K	0.22
BRCA	chr3	50117089	Nonsense_Mutation	NA	R704*	0.33
BRCA	chr3	50100156	Intron	novel		0.09
BRCA	chr3	50118418	Silent	novel	R804R	0.09
BRCA	chr3	50100565	Missense_Mutation	NA	Y148C	0.25
BRCA	chr3	50114016	Frame_Shift_Del	NA	*Q563Sfs6**	0.25
CESC	chr3	50099986	Missense_Mutation	NA	R115P	0.2
CESC	chr3	50114036	Missense_Mutation	NA	L568F	0.24
CESC	chr3	50116107	Intron	NA		0.32
CESC	chr3	50104273	Missense_Mutation	novel	R198T	0.29
CESC	chr3	50093809	Missense_Mutation	novel	I91M	0.39
CESC	chr3	50109627	Missense_Mutation	rs147593355	A406V	0.18
CESC	chr3	50117164	Missense_Mutation	rs145873632	G729S	0.32
CESC	chr3	50115980	Splice_Region	novel	E698E	0.07
CESC	chr3	50117098	Missense_Mutation	novel	E707Q	0.24
CESC	chr3	50100572	Missense_Mutation	NA	L150F	0.4
CESC	chr3	50117090	Missense_Mutation	novel	R704Q	0.25
COAD	chr3	50090381	Splice_Region	novel		0.12
COAD	chr3	50117403	Intron	novel		0.11
COAD	chr3	50100281	Intron	novel		0.38
COAD	chr3	50110754	Missense_Mutation	NA	Y480C	0.24
COAD	chr3	50093871	Missense_Mutation	NA	S112N	0.33
COAD	chr3	50100244	Intron	novel		0.35
COAD	chr3	50117199	Intron	rs752203209		0.14
COAD	chr3	50100244	Intron	novel		0.4
COAD	chr3	50108125	Missense_Mutation	novel	D366G	0.21
COAD	chr3	50113493	Frame_Shift_Del	novel	*E524Rfs28**	0.12
COAD	chr3	50093804	Missense_Mutation	NA	D90N	0.12
COAD	chr3	50104286	Silent	NA	F202F	0.25
COAD	chr3	50118514	3'UTR	novel		0.28
DLBC	chr3	50117319	Missense_Mutation	novel	M754I	0.1	zf-RanBP
ESCA	chr3	50113459	Missense_Mutation	novel	S511F	0.53
ESCA	chr3	50100281	Intron	novel		0.45
ESCA	chr3	50100173	Intron	novel		0.35
GBM	chr3	50093781	Frame_Shift_Del	novel	*Y82Lfs36**	0.03
GBM	chr3	50117451	Intron	novel		0.34
GBM	chr3	50110732	Missense_Mutation	novel	D473Y	0.07
GBM	chr3	50100080	Intron	novel		0.33
GBM	chr3	50107515	Silent	rs751202488	S329S	0.2
GBM	chr3	50116070	Intron	novel		0.07
HNSC	chr3	50105090	Silent	novel	E214E	0.13
HNSC	chr3	50105547	Splice_Site	novel	X232_splice	0.43
HNSC	chr3	50093731	Missense_Mutation	novel	E65D	0.33
HNSC	chr3	50109657	Missense_Mutation	novel	Y416C	0.35
HNSC	chr3	50107559	Missense_Mutation	novel	S344L	0.42
HNSC	chr3	50114055	Missense_Mutation	novel	E575Q	0.45
HNSC	chr3	50108293	Missense_Mutation	novel	S394L	0.14
HNSC	chr3	50106793	Frame_Shift_Del	novel	*Q295Efs9**	0.61
HNSC	chr3	50117437	Intron	novel		0.3
HNSC	chr3	50113541	Splice_Site	novel	X538_splice	0.17
HNSC	chr3	50108293	Nonsense_Mutation	novel	S394*	0.41
KIRC	chr3	50106842	Frame_Shift_Ins	novel	*D311Afs21**	0.06
KIRP	chr3	50110435	Silent	NA	P445P	0.24
KIRP	chr3	50092185	Missense_Mutation	novel	Y54D	0.57
KIRP	chr3	50090418	5'UTR	novel		0.47
LGG	chr3	50093869	Nonsense_Mutation	novel	*S112Lfs3**	0.05
LIHC	chr3	50100025	Missense_Mutation	novel	D128A	0.32
LIHC	chr3	50105649	Missense_Mutation	novel	I265M	0.26
LIHC	chr3	50108108	Nonsense_Mutation	novel	Y360*	0.27
LUAD	chr3	50115957	Missense_Mutation	NA	A691P	0.17
LUAD	chr3	50100497	Intron	novel		0.29
LUAD	chr3	50108148	Splice_Site	NA	X373_splice	0.14
LUAD	chr3	50117333	Missense_Mutation	NA	G759V	0.06	zf-RanBP
LUAD	chr3	50100040	Missense_Mutation	novel	K133M	0.25
LUAD	chr3	50100041	Missense_Mutation	novel	K133N	0.25
LUAD	chr3	50109652	Silent	NA	Q414Q	0.29
LUAD	chr3	50110712	Missense_Mutation	novel	E466V	0.19
LUSC	chr3	50093825	Missense_Mutation	novel	S97G	0.11
LUSC	chr3	50106821	Missense_Mutation	novel	D304H	0.79
LUSC	chr3	50114092	Missense_Mutation	NA	E587G	0.12
LUSC	chr3	50105702	Missense_Mutation	novel	S283F	0.31
LUSC	chr3	50114096	Missense_Mutation	novel	K588N	0.23
LUSC	chr3	50115924	Nonsense_Mutation	NA	R680*	0.76
LUSC	chr3	50093742	Missense_Mutation	novel	S69I	0.63
LUSC	chr3	50103167	Splice_Site	novel	X189_splice	0.41
LUSC	chr3	50108123	Splice_Site	novel	X367_splice	0.13
MESO	chr3	50100752	Intron	novel		0.29
OV	chr3	50116925	Intron	novel		0.21
OV	chr3	50093718	Splice_Site	novel	X62_splice	0.12
OV	chr3	50117207	Intron	rs369033948		0.29
PAAD	chr3	50104278	Missense_Mutation	novel	K200E	0.23
PRAD	chr3	50109688	Splice_Region	NA	P426P	0.29
PRAD	chr3	50090386	5'UTR	novel		0.28
PRAD	chr3	50114222	Nonsense_Mutation	NA	R604*	0.43
READ	chr3	50113998	Nonsense_Mutation	NA	E556*	0.22
READ	chr3	50110433	Missense_Mutation	novel	P445S	0.34
READ	chr3	50117198	Intron	rs376075399		0.38
READ	chr3	50118340	Missense_Mutation	rs768916982	R778W	0.43	zf-RanBP
READ	chr3	50115473	Nonsense_Mutation	novel	E629*	0.13
SARC	chr3	50115559	Silent	rs760097229	P657P	0.15
SKCM	chr3	50115550	Silent	NA	R654R	0.43
SKCM	chr3	50110760	Missense_Mutation	NA	P482L	0.4
SKCM	chr3	50118418	Missense_Mutation	NA	R804W	0.24
SKCM	chr3	50100472	Intron	novel		0.38
SKCM	chr3	50106809	Missense_Mutation	NA	P300S	0.3
SKCM	chr3	50117210	Intron	novel		0.27
SKCM	chr3	50118417	Silent	NA	V803V	0.14
SKCM	chr3	50109677	Missense_Mutation	NA	P423S	0.18
SKCM	chr3	50114049	Frame_Shift_Ins	novel	*R574Efs14**	0.15
SKCM	chr3	50118420	Silent	NA	R804R	0.46
SKCM	chr3	50093837	Missense_Mutation	novel	M101L	0.4
SKCM	chr3	50093838	Missense_Mutation	novel	M101R	0.4
SKCM	chr3	50103132	Missense_Mutation	NA	P178L	0.33
SKCM	chr3	50114007	Missense_Mutation	NA	K559E	0.5
SKCM	chr3	50100076	Intron	novel		0.41
SKCM	chr3	50109686	Missense_Mutation	NA	P426S	0.76
SKCM	chr3	50100070	Intron	novel		0.47
SKCM	chr3	50100539	Silent	NA	S139S	0.47
SKCM	chr3	50117529	Intron	novel		0.43
SKCM	chr3	50114032	Missense_Mutation	novel	S567F	0.28
STAD	chr3	50092188	Nonsense_Mutation	novel	R55*	0.21
STAD	chr3	50093805	Missense_Mutation	novel	D90A	0.2
STAD	chr3	50115978	Missense_Mutation	NA	E698K	0.22
STAD	chr3	50117223	Intron	novel		0.09
STAD	chr3	50116053	Intron	novel		0.15
STAD	chr3	50092107	Missense_Mutation	NA	R28C	0.16
STAD	chr3	50118434	Missense_Mutation	novel	A809D	0.44
STAD	chr3	50092162	Missense_Mutation	rs372517136	R46Q	0.31
STAD	chr3	50107491	Frame_Shift_Del	novel	*L322Sfs12**	0.31
STAD	chr3	50092189	Missense_Mutation	rs746587173	R55Q	0.44
STAD	chr3	50110427	Missense_Mutation	NA	A443T	0.13
STAD	chr3	50116078	Intron	novel		0.27
THCA	chr3	50116109	Intron	novel		0.17
THCA	chr3	50113533	Frame_Shift_Ins	novel	*T536Kfs20**	0.07
THCA	chr3	50113533	Frame_Shift_Ins	novel	*T536Kfs20**	0.08
THYM	chr3	50113245	Intron	novel		0.33
THYM	chr3	50093845	Silent	rs566441117	R103R	0.34
UCEC	chr3	50100561	Missense_Mutation	novel	F147V	0.28
UCEC	chr3	50100563	Missense_Mutation	novel	F147L	0.26
UCEC	chr3	50116998	Intron	novel		0.39
UCEC	chr3	50113379	Splice_Region	novel		0.27
UCEC	chr3	50113388	Silent	novel	Y487Y	0.44
UCEC	chr3	50115528	Missense_Mutation	novel	M647T	0.08
UCEC	chr3	50118342	Silent	NA	R778R	0.35
UCEC	chr3	50118130	Intron	novel		0.6
UCEC	chr3	50108243	Missense_Mutation	novel	D377E	0.42
UCEC	chr3	50115959	Silent	novel	A691A	0.08
UCEC	chr3	50109677	Missense_Mutation	NA	P423S	0.52
UCEC	chr3	50108242	Missense_Mutation	novel	D377V	0.19
UCEC	chr3	50118205	Intron	novel		0.27
UCEC	chr3	50093843	Missense_Mutation	rs776910364	R103C	0.25
UCEC	chr3	50100281	Intron	novel		0.52
UCEC	chr3	50103097	Silent	novel	I166I	0.4
UCEC	chr3	50093851	Silent	novel	L105L	0.14
UCEC	chr3	50115532	Silent	novel	A648A	0.21
UCEC	chr3	50100281	Intron	novel		0.58
UCEC	chr3	50105618	Missense_Mutation	rs764752703	A255V	0.38
UCEC	chr3	50100281	Intron	novel		0.5
UCEC	chr3	50118180	Intron	novel		0.5
UCEC	chr3	50116062	Intron	novel		0.08
UCEC	chr3	50100281	Intron	novel		0.3
UCEC	chr3	50113433	Missense_Mutation	novel	K502N	0.17
UCEC	chr3	50117118	Silent	novel	G713G	0.09
UCEC	chr3	50093845	Silent	rs566441117	R103R	0.49
UCEC	chr3	50113981	Missense_Mutation	novel	S550I	0.3
UCEC	chr3	50117115	Silent	rs750310851	Y712Y	0.44
UCEC	chr3	50118794	3'UTR	novel		0.3
UCEC	chr3	50100281	Intron	novel		0.56
UCEC	chr3	50114007	Frame_Shift_Del	novel	*N560Ifs9**	0.45
UCEC	chr3	50113969	Missense_Mutation	novel	R546H	0.59
UCEC	chr3	50093756	Missense_Mutation	novel	D74Y	0.63
UCEC	chr3	50092186	Missense_Mutation	rs370608309	Y54C	0.18
UCEC	chr3	50110770	Splice_Region	NA	Q485Q	0.33
UCEC	chr3	50100281	Intron	novel		0.25
UCEC	chr3	50093791	Silent	rs144164147	H85H	0.35
UCEC	chr3	50113346	Intron	novel		0.3
UCEC	chr3	50116062	Intron	novel		0.08
UCEC	chr3	50118708	3'UTR	novel		0.27
UCEC	chr3	50105573	Missense_Mutation	novel	P240L	0.48
UCEC	chr3	50117198	Intron	rs376075399		0.35
UCEC	chr3	50092185	Missense_Mutation	rs771796030	Y54H	0.26
UCEC	chr3	50092191	Missense_Mutation	novel	D56Y	0.33
UCEC	chr3	50090409	5'UTR	novel		0.2
UCEC	chr3	50100215	Intron	novel		0.33
UCEC	chr3	50100664	Intron	rs574947002		0.44
UCEC	chr3	50106864	Missense_Mutation	novel	K318R	0.45
UCEC	chr3	50116062	Intron	novel		0.08
UCEC	chr3	50100281	Intron	novel		0.4
UCEC	chr3	50116957	Intron	novel		0.23
UCEC	chr3	50114222	Nonsense_Mutation	NA	R604*	0.51
UCEC	chr3	50100244	Intron	novel		0.48
UCEC	chr3	50100244	Intron	novel		0.57
UCEC	chr3	50114072	Silent	rs771260903	D580D	0.37
UCEC	chr3	50100022	Missense_Mutation	rs139289182	A127V	0.36
UCEC	chr3	50100541	Missense_Mutation	novel	R140H	0.36
UCEC	chr3	50105618	Missense_Mutation	rs764752703	A255V	0.39
UCEC	chr3	50107516	Missense_Mutation	NA	A330T	0.43
UCEC	chr3	50105683	Missense_Mutation	NA	A277T	0.3
UCS	chr3	50116123	Intron	novel		0.67

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2833	4.5968e-31
CHOL	DEL	0.7778	0.02241
DLBC	DEL	0.125	0.016959
GBM	DEL	0.0763	0.056565
LGG	DEL	0.078	0.00089193
LUAD	DEL	0.3391	0.0021265
PAAD	DEL	0.1957	0.030662
SARC	DEL	0.2179	0.0034746
SKCM	DEL	0.1635	0.13887
TGCT	AMP	0.12	0.23596
TGCT	DEL	0.1867	0.08422
THYM	DEL	0.0732	0.037527

Survival Analysis

Cancer	P-value	Q-value
THYM	0.019	Kaplan-Meier Survival Analysis
KIRC	0.001	Kaplan-Meier Survival Analysis
MESO	0.0032	Kaplan-Meier Survival Analysis
ACC	0.00093	Kaplan-Meier Survival Analysis
HNSC	0.026	Kaplan-Meier Survival Analysis
PRAD	0.048	Kaplan-Meier Survival Analysis
BRCA	0.0051	Kaplan-Meier Survival Analysis
KIRP	0.048	Kaplan-Meier Survival Analysis
COAD	0.042	Kaplan-Meier Survival Analysis
PAAD	0.00018	Kaplan-Meier Survival Analysis
BLCA	0.0015	Kaplan-Meier Survival Analysis
KICH	0.0093	Kaplan-Meier Survival Analysis
LIHC	0.002	Kaplan-Meier Survival Analysis
LUAD	0.0037	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000003756 (Gene tree)
Gene ID: 10181
Gene Symbol: RBM5
Alias: LUCA15|LUCA-15|H37
Full Name: RNA binding motif protein 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 30,114 bases
Position: chr3:50,088,908-50,119,021
Accession: 9902
RBP type: canonical RBP
Summary: This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000343054	zf-RanBP	PF00641.18	3.5e-09	1	1
ENSP00000343054	RRM_1	PF00076.22	5.5e-14	1	1
ENSP00000343054	G-patch	PF01585.23	1.9e-18	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17908320	RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours.	BMC Genomics	2007 Oct 1	Wang K	-
20309933	p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.	Int J Cancer	2011 Jan 15	Kobayashi T	doi: 10.1002/ijc.25345
18315527	S1-1 nuclear domains: characterization and dynamics as a function of transcriptional activity.	Biol Cell	2008 Sep	Inoue A	doi: 10.1042/BC20070142.
21256132	Characterization of a family of RanBP2-type zinc fingers that can recognize single-stranded RNA.	J Mol Biol	2011 Mar 25	Nguyen CD	doi: 10.1016/j.jmb.2010.12.041
25578565	RBM5 and p53 expression after rat spinal cord injury: implications for neuronal apoptosis.	Int J Biochem Cell Biol	2015 Mar	Zhang J	doi: 10.1016/j.biocel.2014.12.020
30221674	Prognostic value and potential function of splicing events in prostate adenocarcinoma.	Int J Oncol	2018 Dec	Huang ZG	doi: 10.3892/ijo.2018.4563
10352938	A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3.	Eur J Hum Genet	1999 May-Jun	Timmer T	-
10353602	DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC.	Oncogene	1999 Apr 22	Drabkin HA	-
16546166	Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes.	Exp Cell Res	2006 Jun 10	Mourtada-Maarabouni M	-
22866867	The tumor suppressor gene RBM5 inhibits lung adenocarcinoma cell growth and induces apoptosis.	World J Surg Oncol	2012 Aug 6	Shao C	doi: 10.1186/1477-7819-10-160.
22162216	Targeting zinc finger domains with small molecules: solution structure and binding studies of the RanBP2-type zinc finger of RBM5.	Chembiochem	2011 Dec 16	Farina B	doi: 10.1002/cbic.201100582.
24486491	The RNA recognition motif domains of RBM5 are required for RNA binding and cancer cell proliferation inhibition.	Biochem Biophys Res Commun	2014 Feb 14	Zhang L	doi: 10.1016/j.bbrc.2014.01.102
23721095	Tumor suppressor gene RBM5 delivered by attenuated Salmonella inhibits lung adenocarcinoma through diverse apoptotic signaling pathways.	World J Surg Oncol	2013 May 31	Shao C	doi: 10.1186/1477-7819-11-123.
23935508	RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility.	PLoS Genet	2013	O'Bryan MK	doi: 10.1371/journal.pgen.1003628
26782095	RNA-binding motif protein 5 inhibits the proliferation of cigarette smoke-transformed BEAS-2B cells through cell cycle arrest and apoptosis.	Oncol Rep	2016 Apr	Lv XJ	doi: 10.3892/or.2016.4551
26767003	Identification of mutant genes with high-frequency, high-risk, and high-expression in lung adenocarcinoma.	Thorac Cancer	2014 May	Li G	doi: 10.1111/1759-7714.12080
25738917	RNA-binding motif protein 5 negatively regulates the activity of Wnt/β-catenin signaling in cigarette smoke-induced alveolar epithelial injury.	Oncol Rep	2015 May	Hao YQ	doi: 10.3892/or.2015.3828
29199590	Regulating RNA Binding Motif 5 Gene Expression- A Novel Therapeutic Target for Lung Cancer.	J Environ Pathol Toxicol Oncol	2017	Prabhu VV	doi: 10.1615/JEnvironPatholToxicolOncol.2017019366.
31318608	Down-regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR-432-5p/β-catenin feedback loop.	FASEB J	2019 Jul 18:fj201900537R	Zhang YP	doi: 10.1096/fj.201900537R
15514923	RNA binding motif (RBM) proteins: a novel family of apoptosis modulators?	J Cell Biochem	2005 Jan 1	Sutherland LC	-
22839758	Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets.	Biochemistry	2012 Aug 21	Song Z	doi: 10.1021/bi300539t
16927403	The apoptosis modulator and tumour suppressor protein RBM5 is a phosphoprotein.	Cell Biochem Funct	2007 Nov-Dec	Shu Y	-
11029660	LUCA15, a putative tumour suppressor gene encoding an RNA-binding nuclear protein, is down-regulated in ras-transformed Rat-1 cells.	Genes Cells	2000 Oct	Edamatsu H	-
23425895	Differential expression of RBM5 and KRAS in pancreatic ductal adenocarcinoma and their association with clinicopathological features.	Oncol Lett	2013 Mar	Peng J	-
20186023	RBM5 as a putative tumor suppressor gene for lung cancer.	J Thorac Oncol	2010 Mar	Sutherland LC	doi: 10.1097/JTO.0b013e3181c6e330.
23017209	RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract.	FEBS Lett	2012 Nov 2	Jin W	doi: 10.1016/j.febslet.2012.09.006
22569250	Tumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activity.	FEBS Lett	2012 Apr 5	Niu Z	doi: 10.1016/j.febslet.2012.02.052
22537942	Differential expression of RBM5, EGFR and KRAS mRNA and protein in non-small cell lung cancer tissues.	J Exp Clin Cancer Res	2012 Apr 26	Liang H	doi: 10.1186/1756-9966-31-36.
23158838	3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis.	World J Surg Oncol	2012 Nov 16	Zhao L	doi: 10.1186/1477-7819-10-247.
25586139	The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice.	J Cereb Blood Flow Metab	2015 Mar 31	Jackson TC	doi: 10.1038/jcbfm.2014.242.
25441176	Lentiviral vector-mediated RBM5 overexpression downregulates EGFR expression in human non-small cell lung cancer cells.	World J Surg Oncol	2014 Dec 2	Su Z	doi: 10.1186/1477-7819-12-367.
25355266	[Construction of RBM5 vector, establishment of stably transfected A549 cell line and preliminary research on the function of RBM5 gene].	Zhong Nan Da Xue Xue Bao Yi Xue Ban	2014 Oct	Xiao J	doi: 10.11817/j.issn.1672-7347.2014.10.002.
24332178	RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.	Mol Cell	2013 Dec 12	Bechara EG	doi: 10.1016/j.molcel.2013.11.010.
28061901	RBM5 inhibits tumorigenesis of gliomas through inhibition of Wnt/β-catenin signaling and induction of apoptosis.	World J Surg Oncol	2017 Jan 6	Jiang Y	doi: 10.1186/s12957-016-1084-1.
26923134	Overexpression of RBM5 induces autophagy in human lung adenocarcinoma cells.	World J Surg Oncol	2016 Feb 29	Su Z	doi: 10.1186/s12957-016-0815-7.
26712279	Nuclear Magnetic Resonance Structure of a Novel Globular Domain in RBM10 Containing OCRE, the Octamer Repeat Sequence Motif.	Structure	2016 Jan 5	Martin BT	doi: 10.1016/j.str.2015.10.029
26784654	Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels.	Gene	2016 Apr 10	Ozuemba B	doi: 10.1016/j.gene.2015.12.070
28662214	RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.	PLoS One	2017 Jun 29	Loiselle JJ	doi: 10.1371/journal.pone.0180258
28818525	Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons.	Neuroscience	2017 Oct 11	Jackson TC	doi: 10.1016/j.neuroscience.2017.08.014
29176597	In vivo evidence that RBM5 is a tumour suppressor in the lung.	Sci Rep	2017 Nov 24	Jamsai D	doi: 10.1038/s41598-017-15874-9.
30295127	RBM-5 modulates U2AF large subunit-dependent alternative splicing in C. elegans.	RNA Biol	2018	Zhou C	doi: 10.1080/15476286.2018.1526540
30675268	Role of RNA-binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer.	Oncol Lett	2019 Feb	Xu Y	doi: 10.3892/ol.2018.9818
30964162	LncRNA AB073614 promotes the proliferation and inhibits apoptosis of cervical cancer cells by repressing RBM5.	Eur Rev Med Pharmacol Sci	2019 Mar	Guo LY	doi: 10.26355/eurrev_201903_17382.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000438369	RBM5-207	560	-	ENSP00000414218	81 (aa)	-	F8WE23
ENST00000464988	RBM5-213	877	-	-	- (aa)	-	-
ENST00000464087	RBM5-212	5616	-	-	- (aa)	-	-
ENST00000496179	RBM5-226	1406	-	-	- (aa)	-	-
ENST00000475128	RBM5-218	1371	-	-	- (aa)	-	-
ENST00000441305	RBM5-208	569	-	ENSP00000390711	137 (aa)	-	C9JFQ5
ENST00000493993	RBM5-224	476	-	-	- (aa)	-	-
ENST00000395174	RBM5-202	938	-	ENSP00000378603	56 (aa)	-	H7BYM9
ENST00000404526	RBM5-203	580	-	ENSP00000384872	138 (aa)	-	F8W910
ENST00000492430	RBM5-222	580	-	-	- (aa)	-	-
ENST00000417905	RBM5-204	427	-	ENSP00000406119	120 (aa)	-	C9J9P7
ENST00000471995	RBM5-215	762	-	-	- (aa)	-	-
ENST00000441812	RBM5-209	583	-	-	- (aa)	-	-
ENST00000475590	RBM5-219	704	-	-	- (aa)	-	-
ENST00000492472	RBM5-223	902	-	-	- (aa)	-	-
ENST00000462025	RBM5-211	573	-	-	- (aa)	-	-
ENST00000469838	RBM5-214	2716	-	ENSP00000419534	143 (aa)	-	P52756
ENST00000347869	RBM5-201	3188	XM_006712917	ENSP00000343054	815 (aa)	XP_006712980	P52756
ENST00000479275	RBM5-220	1683	-	-	- (aa)	-	-
ENST00000474470	RBM5-216	434	-	-	- (aa)	-	-
ENST00000461242	RBM5-210	275	-	-	- (aa)	-	-
ENST00000433556	RBM5-205	567	-	-	- (aa)	-	-
ENST00000474818	RBM5-217	832	-	-	- (aa)	-	-
ENST00000489437	RBM5-221	625	-	-	- (aa)	-	-
ENST00000494360	RBM5-225	585	-	-	- (aa)	-	-
ENST00000437500	RBM5-206	582	-	ENSP00000394622	105 (aa)	-	C9JR02

Gene Model

Click here to download ENSG00000003756's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000003756	Alcoholism	4.44E-05	-
ENSG00000003756	Cholesterol, HDL	9E-12	24097068

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000003756	rs2013208	3	50091966	T	HDL cholesterol	24097068	[NR] unit increase	0.025	EFO_0004612
ENSG00000003756	rs2013208	3	50091966	T	HDL cholesterol levels	28334899	[0.018-0.032] unit increase (EA Beta values)	0.0254	EFO_0004612
ENSG00000003756	rs2013208	3	50091966	T	Intelligence	29942086	z-score increase	9.775	EFO_0004337
ENSG00000003756	rs2624834	3	50094698	G	Heel bone mineral density	30598549	[0.013-0.022] unit increase	0.0175388	EFO_0009270
ENSG00000003756	rs2013208	3	50091966	T	HDL cholesterol x physical activity interaction (2df test)	30670697			EFO_0007805\|EFO_0003940

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000003756's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000003756	RBM5	98	50.378	ENSG00000182872	RBM10	98	51.765
ENSG00000003756	RBM5	70	36.870	ENSG00000004534	RBM6	71	37.666

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000003756	RBM5	100	62.197	ENSAPOG00000016625	rbm5	100	61.717	Acanthochromis_polyacanthus
ENSG00000003756	RBM5	100	60.473	ENSAPOG00000006011	-	100	60.999	Acanthochromis_polyacanthus
ENSG00000003756	RBM5	100	100.000	ENSAMEG00000012005	RBM5	100	99.387	Ailuropoda_melanoleuca
ENSG00000003756	RBM5	99	58.504	ENSACIG00000021310	-	99	56.695	Amphilophus_citrinellus
ENSG00000003756	RBM5	76	60.348	ENSACIG00000007571	rbm5	100	59.335	Amphilophus_citrinellus
ENSG00000003756	RBM5	100	61.795	ENSAOCG00000002880	rbm5	100	61.795	Amphiprion_ocellaris
ENSG00000003756	RBM5	99	60.195	ENSAOCG00000017312	-	99	60.073	Amphiprion_ocellaris
ENSG00000003756	RBM5	90	60.764	ENSAPEG00000011862	rbm5	92	61.274	Amphiprion_percula
ENSG00000003756	RBM5	100	60.947	ENSAPEG00000018222	RBM5	100	60.999	Amphiprion_percula
ENSG00000003756	RBM5	100	61.717	ENSATEG00000024663	rbm5	100	61.601	Anabas_testudineus
ENSG00000003756	RBM5	100	59.346	ENSATEG00000003838	-	100	57.827	Anabas_testudineus
ENSG00000003756	RBM5	94	87.304	ENSAPLG00000011176	RBM5	99	86.280	Anas_platyrhynchos
ENSG00000003756	RBM5	100	84.892	ENSACAG00000008580	RBM5	100	85.594	Anolis_carolinensis
ENSG00000003756	RBM5	100	100.000	ENSANAG00000025199	RBM5	100	99.632	Aotus_nancymaae
ENSG00000003756	RBM5	100	61.609	ENSACLG00000012748	rbm5	100	61.583	Astatotilapia_calliptera
ENSG00000003756	RBM5	89	75.610	ENSACLG00000024198	RBM5	100	56.872	Astatotilapia_calliptera
ENSG00000003756	RBM5	84	63.686	ENSAMXG00000008146	rbm5	99	64.227	Astyanax_mexicanus
ENSG00000003756	RBM5	100	100.000	ENSBTAG00000006330	RBM5	100	99.141	Bos_taurus
ENSG00000003756	RBM5	100	100.000	ENSCJAG00000004740	RBM5	100	99.632	Callithrix_jacchus
ENSG00000003756	RBM5	100	100.000	ENSCAFG00000010866	RBM5	100	99.509	Canis_familiaris
ENSG00000003756	RBM5	100	100.000	ENSCAFG00020022126	RBM5	100	99.509	Canis_lupus_dingo
ENSG00000003756	RBM5	100	100.000	ENSCHIG00000018435	RBM5	100	99.387	Capra_hircus
ENSG00000003756	RBM5	100	100.000	ENSTSYG00000004158	RBM5	100	98.567	Carlito_syrichta
ENSG00000003756	RBM5	100	100.000	ENSCAPG00000013495	RBM5	100	80.368	Cavia_aperea
ENSG00000003756	RBM5	100	100.000	ENSCPOG00000008151	RBM5	100	98.773	Cavia_porcellus
ENSG00000003756	RBM5	99	99.753	ENSCCAG00000026401	RBM5	99	99.753	Cebus_capucinus
ENSG00000003756	RBM5	100	100.000	ENSCATG00000041038	RBM5	100	99.877	Cercocebus_atys
ENSG00000003756	RBM5	100	100.000	ENSCLAG00000007873	RBM5	100	98.896	Chinchilla_lanigera
ENSG00000003756	RBM5	100	100.000	ENSCSAG00000014401	RBM5	100	99.877	Chlorocebus_sabaeus
ENSG00000003756	RBM5	81	86.989	ENSCHOG00000009429	RBM5	85	86.989	Choloepus_hoffmanni
ENSG00000003756	RBM5	100	86.731	ENSCPBG00000002406	RBM5	100	87.575	Chrysemys_picta_bellii
ENSG00000003756	RBM5	100	100.000	ENSCANG00000031250	RBM5	100	97.423	Colobus_angolensis_palliatus
ENSG00000003756	RBM5	100	100.000	ENSCGRG00001010543	Rbm5	100	98.282	Cricetulus_griseus_chok1gshd
ENSG00000003756	RBM5	100	100.000	ENSCGRG00000008475	Rbm5	100	98.282	Cricetulus_griseus_crigri
ENSG00000003756	RBM5	100	62.727	ENSCSEG00000000596	rbm5	97	59.860	Cynoglossus_semilaevis
ENSG00000003756	RBM5	100	60.814	ENSCVAG00000005655	rbm5	100	60.976	Cyprinodon_variegatus
ENSG00000003756	RBM5	100	59.016	ENSDARG00000098280	rbm5	100	63.245	Danio_rerio
ENSG00000003756	RBM5	100	100.000	ENSDNOG00000011756	RBM5	100	99.141	Dasypus_novemcinctus
ENSG00000003756	RBM5	100	100.000	ENSDORG00000007692	Rbm5	100	99.141	Dipodomys_ordii
ENSG00000003756	RBM5	92	91.867	ENSETEG00000012773	RBM5	93	91.931	Echinops_telfairi
ENSG00000003756	RBM5	80	63.636	ENSEBUG00000017034	rbm5	79	63.636	Eptatretus_burgeri
ENSG00000003756	RBM5	100	100.000	ENSEASG00005011835	RBM5	100	99.632	Equus_asinus_asinus
ENSG00000003756	RBM5	100	100.000	ENSECAG00000020447	RBM5	100	99.632	Equus_caballus
ENSG00000003756	RBM5	96	98.473	ENSEEUG00000005943	RBM5	91	99.505	Erinaceus_europaeus
ENSG00000003756	RBM5	100	63.741	ENSELUG00000022467	rbm5	100	61.156	Esox_lucius
ENSG00000003756	RBM5	100	100.000	ENSFCAG00000014639	RBM5	100	99.387	Felis_catus
ENSG00000003756	RBM5	98	82.847	ENSFALG00000008828	RBM5	83	86.544	Ficedula_albicollis
ENSG00000003756	RBM5	100	99.270	ENSFDAG00000001897	RBM5	100	95.588	Fukomys_damarensis
ENSG00000003756	RBM5	100	64.220	ENSFHEG00000015954	rbm5	100	76.190	Fundulus_heteroclitus
ENSG00000003756	RBM5	99	62.999	ENSGMOG00000016224	rbm5	92	63.165	Gadus_morhua
ENSG00000003756	RBM5	100	51.402	ENSGMOG00000007810	-	100	46.570	Gadus_morhua
ENSG00000003756	RBM5	97	82.169	ENSGALG00000039288	RBM5	83	86.412	Gallus_gallus
ENSG00000003756	RBM5	100	60.739	ENSGAFG00000010690	rbm5	100	61.387	Gambusia_affinis
ENSG00000003756	RBM5	100	57.938	ENSGACG00000000858	-	100	57.895	Gasterosteus_aculeatus
ENSG00000003756	RBM5	100	62.590	ENSGACG00000010469	rbm5	100	62.590	Gasterosteus_aculeatus
ENSG00000003756	RBM5	95	87.105	ENSGAGG00000007935	RBM5	99	87.358	Gopherus_agassizii
ENSG00000003756	RBM5	100	100.000	ENSGGOG00000014490	RBM5	100	99.755	Gorilla_gorilla
ENSG00000003756	RBM5	89	75.610	ENSHBUG00000011901	-	100	57.820	Haplochromis_burtoni
ENSG00000003756	RBM5	100	61.117	ENSHBUG00000001941	rbm5	100	61.085	Haplochromis_burtoni
ENSG00000003756	RBM5	100	100.000	ENSHGLG00000014844	RBM5	100	98.775	Heterocephalus_glaber_female
ENSG00000003756	RBM5	100	100.000	ENSHGLG00100010739	RBM5	100	98.896	Heterocephalus_glaber_male
ENSG00000003756	RBM5	100	55.319	ENSHCOG00000004536	-	100	52.213	Hippocampus_comes
ENSG00000003756	RBM5	100	59.821	ENSHCOG00000017110	rbm5	99	59.012	Hippocampus_comes
ENSG00000003756	RBM5	100	64.512	ENSIPUG00000000640	rbm5	100	64.810	Ictalurus_punctatus
ENSG00000003756	RBM5	100	100.000	ENSSTOG00000013856	RBM5	100	99.141	Ictidomys_tridecemlineatus
ENSG00000003756	RBM5	100	100.000	ENSJJAG00000008844	Rbm5	100	98.896	Jaculus_jaculus
ENSG00000003756	RBM5	100	61.290	ENSKMAG00000006663	rbm5	100	61.610	Kryptolebias_marmoratus
ENSG00000003756	RBM5	100	58.373	ENSLBEG00000010877	-	94	58.560	Labrus_bergylta
ENSG00000003756	RBM5	100	60.438	ENSLBEG00000020858	rbm5	100	60.859	Labrus_bergylta
ENSG00000003756	RBM5	58	61.184	ENSLBEG00000002522	-	94	50.254	Labrus_bergylta
ENSG00000003756	RBM5	99	74.878	ENSLACG00000016572	RBM5	100	76.495	Latimeria_chalumnae
ENSG00000003756	RBM5	100	65.826	ENSLOCG00000010774	rbm5	100	65.823	Lepisosteus_oculatus
ENSG00000003756	RBM5	100	100.000	ENSLAFG00000006733	RBM5	100	99.142	Loxodonta_africana
ENSG00000003756	RBM5	100	100.000	ENSMFAG00000031609	RBM5	100	99.877	Macaca_fascicularis
ENSG00000003756	RBM5	99	99.877	ENSMMUG00000004921	RBM5	99	99.877	Macaca_mulatta
ENSG00000003756	RBM5	100	100.000	ENSMNEG00000044394	RBM5	100	99.755	Macaca_nemestrina
ENSG00000003756	RBM5	100	100.000	ENSMLEG00000034689	RBM5	100	95.951	Mandrillus_leucophaeus
ENSG00000003756	RBM5	100	62.412	ENSMAMG00000023948	-	100	59.685	Mastacembelus_armatus
ENSG00000003756	RBM5	91	76.190	ENSMAMG00000017277	rbm5	99	76.190	Mastacembelus_armatus
ENSG00000003756	RBM5	100	61.609	ENSMZEG00005015328	rbm5	100	61.583	Maylandia_zebra
ENSG00000003756	RBM5	100	57.765	ENSMZEG00005010035	-	100	56.517	Maylandia_zebra
ENSG00000003756	RBM5	93	87.566	ENSMGAG00000003972	RBM5	100	86.508	Meleagris_gallopavo
ENSG00000003756	RBM5	99	98.272	ENSMAUG00000020572	Rbm5	98	98.272	Mesocricetus_auratus
ENSG00000003756	RBM5	100	100.000	ENSMICG00000016179	RBM5	100	99.509	Microcebus_murinus
ENSG00000003756	RBM5	100	99.270	ENSMOCG00000017479	Rbm5	100	98.405	Microtus_ochrogaster
ENSG00000003756	RBM5	99	51.582	ENSMMOG00000021804	-	93	52.918	Mola_mola
ENSG00000003756	RBM5	100	63.303	ENSMMOG00000015342	rbm5	100	57.077	Mola_mola
ENSG00000003756	RBM5	100	96.190	ENSMODG00000012301	RBM5	100	94.492	Monodelphis_domestica
ENSG00000003756	RBM5	100	58.491	ENSMALG00000016769	-	100	57.500	Monopterus_albus
ENSG00000003756	RBM5	99	60.801	ENSMALG00000000609	rbm5	99	59.223	Monopterus_albus
ENSG00000003756	RBM5	100	100.000	MGP_CAROLIEiJ_G0032660	Rbm5	100	99.602	Mus_caroli
ENSG00000003756	RBM5	100	100.000	ENSMUSG00000032580	Rbm5	100	99.602	Mus_musculus
ENSG00000003756	RBM5	100	100.000	MGP_PahariEiJ_G0015528	Rbm5	100	100.000	Mus_pahari
ENSG00000003756	RBM5	100	100.000	MGP_SPRETEiJ_G0033805	Rbm5	100	100.000	Mus_spretus
ENSG00000003756	RBM5	100	98.540	ENSMLUG00000007875	RBM5	100	98.160	Myotis_lucifugus
ENSG00000003756	RBM5	100	100.000	ENSNGAG00000011777	Rbm5	100	98.528	Nannospalax_galili
ENSG00000003756	RBM5	96	58.488	ENSNBRG00000004400	RBM5	95	57.455	Neolamprologus_brichardi
ENSG00000003756	RBM5	100	61.003	ENSNBRG00000018097	rbm5	100	60.970	Neolamprologus_brichardi
ENSG00000003756	RBM5	100	100.000	ENSNLEG00000006943	RBM5	100	99.755	Nomascus_leucogenys
ENSG00000003756	RBM5	96	94.656	ENSMEUG00000012994	RBM5	100	88.039	Notamacropus_eugenii
ENSG00000003756	RBM5	92	95.053	ENSOPRG00000015154	RBM5	93	95.093	Ochotona_princeps
ENSG00000003756	RBM5	100	100.000	ENSODEG00000016254	-	100	98.773	Octodon_degus
ENSG00000003756	RBM5	100	91.411	ENSODEG00000019111	-	100	91.411	Octodon_degus
ENSG00000003756	RBM5	100	61.460	ENSONIG00000004107	rbm5	100	61.432	Oreochromis_niloticus
ENSG00000003756	RBM5	100	58.789	ENSONIG00000019007	RBM5	100	58.907	Oreochromis_niloticus
ENSG00000003756	RBM5	88	94.685	ENSOANG00000006557	RBM5	100	94.685	Ornithorhynchus_anatinus
ENSG00000003756	RBM5	100	99.048	ENSOCUG00000011652	RBM5	100	97.791	Oryctolagus_cuniculus
ENSG00000003756	RBM5	100	58.182	ENSORLG00000003369	rbm5	99	60.294	Oryzias_latipes
ENSG00000003756	RBM5	100	55.477	ENSORLG00000001053	-	100	55.136	Oryzias_latipes
ENSG00000003756	RBM5	95	54.187	ENSORLG00020006782	-	98	53.827	Oryzias_latipes_hni
ENSG00000003756	RBM5	100	61.700	ENSORLG00020021744	rbm5	100	60.397	Oryzias_latipes_hni
ENSG00000003756	RBM5	91	76.190	ENSORLG00015018379	rbm5	99	76.190	Oryzias_latipes_hsok
ENSG00000003756	RBM5	95	54.895	ENSORLG00015002854	-	98	54.534	Oryzias_latipes_hsok
ENSG00000003756	RBM5	68	62.500	ENSOMEG00000010653	-	89	62.500	Oryzias_melastigma
ENSG00000003756	RBM5	100	61.476	ENSOMEG00000002219	rbm5	100	61.111	Oryzias_melastigma
ENSG00000003756	RBM5	93	95.497	ENSOGAG00000004205	RBM5	100	95.497	Otolemur_garnettii
ENSG00000003756	RBM5	100	100.000	ENSOARG00000010923	RBM5	100	99.387	Ovis_aries
ENSG00000003756	RBM5	100	100.000	ENSPPAG00000043010	RBM5	100	99.877	Pan_paniscus
ENSG00000003756	RBM5	100	100.000	ENSPPRG00000005404	RBM5	100	99.387	Panthera_pardus
ENSG00000003756	RBM5	100	100.000	ENSPTIG00000000962	RBM5	100	99.387	Panthera_tigris_altaica
ENSG00000003756	RBM5	100	100.000	ENSPTRG00000014946	RBM5	100	99.877	Pan_troglodytes
ENSG00000003756	RBM5	100	100.000	ENSPANG00000018507	RBM5	100	99.877	Papio_anubis
ENSG00000003756	RBM5	94	63.000	ENSPKIG00000022215	-	84	63.462	Paramormyrops_kingsleyae
ENSG00000003756	RBM5	76	57.278	ENSPKIG00000019187	-	100	58.870	Paramormyrops_kingsleyae
ENSG00000003756	RBM5	100	64.815	ENSPKIG00000024837	RBM5	100	61.690	Paramormyrops_kingsleyae
ENSG00000003756	RBM5	88	88.671	ENSPSIG00000016073	RBM5	100	88.671	Pelodiscus_sinensis
ENSG00000003756	RBM5	95	58.416	ENSPMGG00000004719	-	99	73.810	Periophthalmus_magnuspinnatus
ENSG00000003756	RBM5	79	54.977	ENSPMGG00000017347	rbm5	100	54.824	Periophthalmus_magnuspinnatus
ENSG00000003756	RBM5	99	46.565	ENSPMAG00000001998	rbm5	92	46.824	Petromyzon_marinus
ENSG00000003756	RBM5	100	96.190	ENSPCIG00000021531	RBM5	100	94.492	Phascolarctos_cinereus
ENSG00000003756	RBM5	100	60.759	ENSPLAG00000006318	rbm5	100	61.521	Poecilia_latipinna
ENSG00000003756	RBM5	72	60.899	ENSPMEG00000008651	rbm5	98	62.189	Poecilia_mexicana
ENSG00000003756	RBM5	100	63.551	ENSPMEG00000004295	rbm5	100	61.965	Poecilia_mexicana
ENSG00000003756	RBM5	100	60.345	ENSPREG00000003795	rbm5	100	60.880	Poecilia_reticulata
ENSG00000003756	RBM5	96	99.237	ENSPCAG00000005459	RBM5	86	87.500	Procavia_capensis
ENSG00000003756	RBM5	100	100.000	ENSPCOG00000025840	RBM5	100	99.387	Propithecus_coquereli
ENSG00000003756	RBM5	100	100.000	ENSPVAG00000006812	RBM5	100	96.442	Pteropus_vampyrus
ENSG00000003756	RBM5	83	58.626	ENSPNYG00000006361	RBM5	99	58.840	Pundamilia_nyererei
ENSG00000003756	RBM5	100	61.003	ENSPNYG00000014787	rbm5	100	60.970	Pundamilia_nyererei
ENSG00000003756	RBM5	100	63.753	ENSPNAG00000012070	rbm5	100	63.647	Pygocentrus_nattereri
ENSG00000003756	RBM5	100	100.000	ENSRNOG00000018153	Rbm5	100	98.282	Rattus_norvegicus
ENSG00000003756	RBM5	100	100.000	ENSRBIG00000012679	RBM5	100	99.632	Rhinopithecus_bieti
ENSG00000003756	RBM5	100	100.000	ENSRROG00000041331	RBM5	100	99.632	Rhinopithecus_roxellana
ENSG00000003756	RBM5	100	100.000	ENSSBOG00000006324	RBM5	100	99.755	Saimiri_boliviensis_boliviensis
ENSG00000003756	RBM5	100	96.190	ENSSHAG00000018260	RBM5	100	94.724	Sarcophilus_harrisii
ENSG00000003756	RBM5	100	66.981	ENSSFOG00015019645	-	100	65.691	Scleropages_formosus
ENSG00000003756	RBM5	100	64.610	ENSSFOG00015019052	rbm5	94	63.795	Scleropages_formosus
ENSG00000003756	RBM5	100	61.778	ENSSMAG00000017106	rbm5	100	61.201	Scophthalmus_maximus
ENSG00000003756	RBM5	100	62.804	ENSSDUG00000019775	rbm5	100	62.659	Seriola_dumerili
ENSG00000003756	RBM5	100	60.490	ENSSLDG00000015996	-	100	58.237	Seriola_lalandi_dorsalis
ENSG00000003756	RBM5	100	62.572	ENSSLDG00000002329	rbm5	100	62.384	Seriola_lalandi_dorsalis
ENSG00000003756	RBM5	95	99.231	ENSSARG00000009724	-	67	100.000	Sorex_araneus
ENSG00000003756	RBM5	100	90.196	ENSSPUG00000001876	RBM5	85	85.469	Sphenodon_punctatus
ENSG00000003756	RBM5	100	61.440	ENSSPAG00000019638	rbm5	100	62.326	Stegastes_partitus
ENSG00000003756	RBM5	100	61.249	ENSSPAG00000020011	-	100	60.613	Stegastes_partitus
ENSG00000003756	RBM5	100	100.000	ENSSSCG00000011395	RBM5	100	99.387	Sus_scrofa
ENSG00000003756	RBM5	93	79.683	ENSTGUG00000006417	RBM5	98	80.369	Taeniopygia_guttata
ENSG00000003756	RBM5	100	62.963	ENSTRUG00000008292	rbm5	98	67.143	Takifugu_rubripes
ENSG00000003756	RBM5	99	46.796	ENSTNIG00000014742	rbm5	77	63.971	Tetraodon_nigroviridis
ENSG00000003756	RBM5	100	98.095	ENSTBEG00000005424	RBM5	100	91.166	Tupaia_belangeri
ENSG00000003756	RBM5	100	96.350	ENSTTRG00000007717	RBM5	100	92.270	Tursiops_truncatus
ENSG00000003756	RBM5	100	100.000	ENSUAMG00000028347	RBM5	100	99.387	Ursus_americanus
ENSG00000003756	RBM5	100	100.000	ENSUMAG00000022027	RBM5	100	99.387	Ursus_maritimus
ENSG00000003756	RBM5	100	100.000	ENSVPAG00000009388	RBM5	100	98.499	Vicugna_pacos
ENSG00000003756	RBM5	100	100.000	ENSVVUG00000028647	RBM5	100	99.509	Vulpes_vulpes
ENSG00000003756	RBM5	100	60.690	ENSXMAG00000016369	rbm5	100	61.175	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000245	spliceosomal complex assembly	18951082.	IDA	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	18840686.18951082.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003677	DNA binding	10352938.	TAS	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003729	mRNA binding	18840686.	IDA	Function
GO:0005515	protein binding	18951082.22365833.22569250.24304693.26871637.	IPI	Function
GO:0005634	nucleus	18951082.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	18951082.	TAS	Component
GO:0006396	RNA processing	10352938.	TAS	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0008285	negative regulation of cell proliferation	18951082.	TAS	Process
GO:0043065	positive regulation of apoptotic process	18840686.	IDA	Process
GO:0043065	positive regulation of apoptotic process	18951082.	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

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Gene Model

Phenotypes

GWAS

PPI

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Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.