EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23306701	ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma.	Exp Mol Med	2013 Jan 10	Jang JY	doi: 10.1038/emm.2013.1.
27012708	ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells.	Exp Mol Med	2016 Mar 25	Baik SH	doi: 10.1038/emm.2015.126.
25982278	IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.	Oncogene	2016 Mar 10	Hubackova S	doi: 10.1038/onc.2015.162
26842067	Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.	Open Biol	2016 Feb	Gavald??-Navarro A	doi: 10.1098/rsob.150108.
22707389	Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells.	EMBO Mol Med	2012 Sep	Rodriguez N	doi: 10.1002/emmm.201101094
15486956	ANT2 expression under hypoxic conditions produces opposite cell-cycle behavior in 143B and HepG2 cancer cells.	Mol Carcinog	2005 Jan	Chevrollier A	-
18267033	Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo.	Breast Cancer Res	2008	Jang JY	doi: 10.1186/bcr1857
26883272	Targeting Adenine Nucleotide Translocase-2 (ANT2) to Overcome Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Non-Small Cell Lung Cancer.	Mol Cancer Ther	2016 Jun	Jang JY	doi: 10.1158/1535-7163.MCT-15-0089

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chrX	119468485	5'UTR	rs765328027		0.48
BLCA	chrX	119468464	5'UTR	novel		0.6
BLCA	chrX	119469783	Silent	novel	V78V	0.08
BLCA	chrX	119470419	Missense_Mutation	novel	M215I	0.23
BRCA	chrX	119469798	Frame_Shift_Ins	novel	*T84Nfs5**	0.06
CESC	chrX	119471019	Missense_Mutation	NA	F286L	0.41
CESC	chrX	119470392	Missense_Mutation	novel	K206N	0.5
CESC	chrX	119471000	Missense_Mutation	novel	R280K	0.23
CESC	chrX	119469878	Frame_Shift_Del	novel	*W110Cfs32**	0.32
COAD	chrX	119469988	Missense_Mutation	NA	K147E	0.5
COAD	chrX	119468606	Missense_Mutation	NA	R31W	0.37
COAD	chrX	119470410	Silent	novel	I212I	0.38
COAD	chrX	119470922	Missense_Mutation	rs796575701	T254M	0.5
COAD	chrX	119471108	3'UTR	novel		0.08
COAD	chrX	119471141	3'UTR	novel		0.25
COAD	chrX	119470477	Missense_Mutation	NA	R235C	0.54
COAD	chrX	119469957	In_Frame_Del	NA	A137_R138del	0.38
COAD	chrX	119468485	5'UTR	novel		0.83
COAD	chrX	119471073	3'UTR	novel		0.64
COAD	chrX	119469866	Missense_Mutation	NA	R106I	0.3
COAD	chrX	119471041	Frame_Shift_Ins	novel	*I294Kfs28**	0.09
COAD	chrX	119469837	Missense_Mutation	novel	K96N	0.09
DLBC	chrX	119469718	Frame_Shift_Del	novel	*C57Afs85**	0.6
ESCA	chrX	119470489	Missense_Mutation	novel	M239V	0.63
GBM	chrX	119469846	Missense_Mutation	novel	F99L	0.17
HNSC	chrX	119470428	Silent	novel	Q218Q	0.19
KIRP	chrX	119469757	Missense_Mutation	NA	F70V	0.65
LGG	chrX	119468528	Missense_Mutation	novel	A5T	0.31
LUAD	chrX	119468472	5'UTR	rs776683368		0.23
LUAD	chrX	119469870	Silent	novel	T107T	0.21
LUAD	chrX	119469871	Missense_Mutation	novel	Q108K	0.21
LUAD	chrX	119470372	Splice_Site	novel	X200_splice	0.33
LUSC	chrX	119469739	Nonsense_Mutation	novel	E64*	0.55
LUSC	chrX	119469968	Missense_Mutation	novel	R140H	0.12
LUSC	chrX	119470434	Frame_Shift_Del	novel	*T221Lfs6**	0.25
LUSC	chrX	119470062	Missense_Mutation	rs755053633	K171N	0.55
READ	chrX	119470477	Missense_Mutation	NA	R235C	0.22
SKCM	chrX	119470005	Silent	novel	R152R	0.08
SKCM	chrX	119470037	Missense_Mutation	novel	K163R	0.1
SKCM	chrX	119468535	Missense_Mutation	novel	S7F	0.58
SKCM	chrX	119470055	Missense_Mutation	novel	G169E	0.07
SKCM	chrX	119471079	3'UTR	novel		0.63
SKCM	chrX	119470410	Silent	NA	I212I	0.39
STAD	chrX	119468475	5'UTR	novel		0.27
STAD	chrX	119470383	Silent	rs749235460	P203P	0.05
STAD	chrX	119470459	Nonsense_Mutation	novel	*Y229Ffs4**	0.06
STAD	chrX	119470474	Missense_Mutation	NA	V234I	0.23
STAD	chrX	119470478	Missense_Mutation	NA	R235H	0.21
TGCT	chrX	119468528	Missense_Mutation	novel	A5T	0.16
UCEC	chrX	119471140	3'UTR	novel		0.34
UCEC	chrX	119471075	3'UTR	novel		0.35
UCEC	chrX	119470405	Missense_Mutation	rs778572307	V211I	0.05
UCEC	chrX	119468424	5'UTR	novel		0.38
UCEC	chrX	119469763	Missense_Mutation	novel	R72C	0.08
UCEC	chrX	119470112	Missense_Mutation	novel	R188Q	0.5
UCEC	chrX	119469858	Silent	novel	V103V	0.25
UCEC	chrX	119470483	Missense_Mutation	rs753511392	R237C	0.33
UCEC	chrX	119470961	Missense_Mutation	novel	G267D	0.07
UCEC	chrX	119469751	Missense_Mutation	novel	L68M	0.31
UCEC	chrX	119470996	Missense_Mutation	novel	L279I	0.16
UCEC	chrX	119471046	Missense_Mutation	novel	K295N	0.16
UCEC	chrX	119469764	Missense_Mutation	NA	R72H	0.35
UCEC	chrX	119471191	3'UTR	novel		0.27
UCEC	chrX	119470931	Missense_Mutation	novel	C257Y	0.08
UCEC	chrX	119471073	3'UTR	novel		0.36
UCEC	chrX	119468586	Missense_Mutation	NA	T24M	0.17
UCEC	chrX	119469720	Silent	novel	C57C	0.06
UCEC	chrX	119471249	3'UTR	rs753949344		0.45
UCEC	chrX	119470494	Missense_Mutation	novel	M240I	0.13
UCEC	chrX	119468443	5'UTR	novel		0.67
UCEC	chrX	119469866	Missense_Mutation	NA	R106I	0.28
UCEC	chrX	119469764	Missense_Mutation	NA	R72H	0.37
UCS	chrX	119469866	Missense_Mutation	NA	R106I	0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.0284	0.12739
TGCT	DEL	0.0667	0.08422
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0089	Kaplan-Meier Survival Analysis
STAD	0.046	Kaplan-Meier Survival Analysis
SARC	0.0068	Kaplan-Meier Survival Analysis
HNSC	0.01	Kaplan-Meier Survival Analysis
SKCM	0.018	Kaplan-Meier Survival Analysis
BRCA	0.028	Kaplan-Meier Survival Analysis
ESCA	0.00013	Kaplan-Meier Survival Analysis
COAD	0.024	Kaplan-Meier Survival Analysis
CESC	0.0022	Kaplan-Meier Survival Analysis
UCEC	0.016	Kaplan-Meier Survival Analysis
GBM	0.046	Kaplan-Meier Survival Analysis
LIHC	0.022	Kaplan-Meier Survival Analysis
CHOL	0.04	Kaplan-Meier Survival Analysis
THCA	0.04	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000005022 (Gene tree)
Gene ID: 292
Gene Symbol: SLC25A5
Alias: T2|2F1|T3|ANT2
Full Name: solute carrier family 25 member 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 2,997 bases
Position: chrX:119,468,400-119,471,396
Accession: 10991
RBP type: non-canonical RBP
Summary: This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000475354	SLC25A5-204	483	-	-	- (aa)	-	-
ENST00000463551	SLC25A5-203	433	-	-	- (aa)	-	-
ENST00000460013	SLC25A5-202	775	-	-	- (aa)	-	-
ENST00000317881	SLC25A5-201	1274	-	ENSP00000360671	298 (aa)	-	P05141

Gene Model

Click here to download ENSG00000005022's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04020	Calcium signaling pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04217	Necroptosis	KEGG
hsa04218	Cellular senescence	KEGG
hsa05012	Parkinson disease	KEGG
hsa05016	Huntington disease	KEGG
hsa05164	Influenza A	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000005022's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000005022	SLC25A5	100	98.322	ENSMUSG00000016319	Slc25a5	100	98.322	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005471	ATP:ADP antiporter activity	21873635.	IBA	Function
GO:0005515	protein binding	17715127.19116139.19154410.21370995.24725412.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005739	mitochondrion	20833797.	HDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005887	integral component of plasma membrane	2168878.	TAS	Component
GO:0007059	chromosome segregation	-	IEA	Process
GO:0008284	positive regulation of cell proliferation	19154410.	IMP	Process
GO:0015207	adenine transmembrane transporter activity	2168878.	TAS	Function
GO:0015853	adenine transport	-	IEA	Process
GO:0015866	ADP transport	-	IEA	Process
GO:0015867	ATP transport	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0031625	ubiquitin protein ligase binding	19725078.	IPI	Function
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component
GO:0045121	membrane raft	-	IEA	Component
GO:0050796	regulation of insulin secretion	-	TAS	Process
GO:0055085	transmembrane transport	-	IEA	Process
GO:0071817	MMXD complex	20797633.	IDA	Component
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	19154410.	IMP	Process
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.