Cancer | Chr | Position | Mutation Type | dbSNP | Protein-change | Allele Freq | RBD |
---|---|---|---|---|---|---|---|
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
ESCA | |||||||
HNSC | |||||||
LUAD | |||||||
LUAD | |||||||
LUSC | |||||||
LUSC | |||||||
OV | |||||||
PAAD | |||||||
PRAD | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC |
Cancer | Type | Freq | Q-value |
---|---|---|---|
ACC | |||
DLBC | |||
LGG | |||
LIHC | |||
PAAD | |||
PRAD | |||
TGCT | |||
THCA |
Cancer | P-value | Q-value |
---|---|---|
THYM | ||
KIRC | ||
SKCM | ||
LUSC | ||
TGCT | ||
PAAD | ||
CESC | ||
READ | ||
KICH | ||
LGG | ||
UVM | ||
OV |
Protein ID | Domain | Pfam ID | E-value | Domain number | Total number |
---|---|---|---|---|---|
ENSP00000292614 | RNA_pol_L_2 | PF13656.6 | 1.1e-28 | 1 | 1 |
ENSP00000377383 | RNA_pol_L_2 | PF13656.6 | 2.6e-28 | 1 | 1 |
ENSP00000292614 | RNA_pol_L | PF01193.24 | 1.2e-09 | 1 | 1 |
ENSP00000377383 | RNA_pol_L | PF01193.24 | 2.5e-09 | 1 | 1 |
Transcript ID | Name | Length | RefSeq ID | Protein ID | Length | RefSeq ID | UniportKB ID |
---|---|---|---|---|---|---|---|
ENST00000393794 | POLR2J-202 | 784 | XM_005250452 | ENSP00000377383 | 158 (aa) | XP_005250509 | F6S314 |
ENST00000292614 | POLR2J-201 | 932 | XM_017012353 | ENSP00000292614 | 117 (aa) | XP_016867842 | P52435 |
ensgID | SNP | Chromosome | Position | SNP-risk | Trait | PubmedID | 95% CI | Or or BEAT | EFO ID |
---|---|---|---|---|---|---|---|---|---|
ENSG00000005075 | rs369574511 | 7 | 102478605 | C | Breast cancer | 29059683 | [0.023-0.05] unit decrease | 0.0364 | EFO_0000305 |
ENSG00000005075 | rs1131359 | 7 | 102473643 | T | Chronotype | 30696823 | [0.029-0.05] unit increase | 0.039267 | EFO_0008328 |
Ensembl ID | Gene Symbol | Coverage | Identiy | Paralog | Gene Symbol | Coverage | Identiy |
---|---|---|---|---|---|---|---|
ENSG00000005075 | POLR2J | 100 | 98.734 | ENSG00000228049 | POLR2J2 | 100 | 98.734 |
Ensembl ID | Gene Symbol | Coverage | Identiy | Ortholog | Gene Symbol | Coverage | Identiy | Species |
---|---|---|---|---|---|---|---|---|
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSAPOG00000019538 | polr2j | 100 | 94.872 | Acanthochromis_polyacanthus |
ENSG00000005075 | POLR2J | 100 | 92.126 | ENSAMEG00000015480 | - | 100 | 92.126 | Ailuropoda_melanoleuca |
ENSG00000005075 | POLR2J | 93 | 71.818 | ENSACIG00000014549 | POLR2J2 | 91 | 71.818 | Amphilophus_citrinellus |
ENSG00000005075 | POLR2J | 100 | 94.017 | ENSAOCG00000006937 | polr2j | 100 | 94.017 | Amphiprion_ocellaris |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSAPEG00000021761 | polr2j | 100 | 94.872 | Amphiprion_percula |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSATEG00000013312 | - | 100 | 94.872 | Anabas_testudineus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSATEG00000009731 | polr2j | 100 | 94.872 | Anabas_testudineus |
ENSG00000005075 | POLR2J | 86 | 98.020 | ENSAPLG00000003744 | - | 100 | 98.020 | Anas_platyrhynchos |
ENSG00000005075 | POLR2J | 100 | 90.598 | ENSACAG00000000251 | POLR2J | 100 | 90.598 | Anolis_carolinensis |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSACLG00000014564 | polr2j | 100 | 94.872 | Astatotilapia_calliptera |
ENSG00000005075 | POLR2J | 100 | 96.581 | ENSAMXG00000007517 | polr2j | 100 | 96.581 | Astyanax_mexicanus |
ENSG00000005075 | POLR2J | 62 | 68.493 | ENSBTAG00000048046 | - | 61 | 68.493 | Bos_taurus |
ENSG00000005075 | POLR2J | 94 | 70.000 | WBGene00012187 | rpb-11 | 89 | 70.000 | Caenorhabditis_elegans |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSCJAG00000016203 | - | 100 | 100.000 | Callithrix_jacchus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSCAFG00000013683 | - | 100 | 100.000 | Canis_familiaris |
ENSG00000005075 | POLR2J | 85 | 100.000 | ENSTSYG00000029243 | - | 85 | 100.000 | Carlito_syrichta |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSCPOG00000001401 | - | 100 | 100.000 | Cavia_porcellus |
ENSG00000005075 | POLR2J | 100 | 74.359 | ENSCATG00000016595 | - | 96 | 84.615 | Cercocebus_atys |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSCLAG00000005238 | - | 100 | 100.000 | Chinchilla_lanigera |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSCSAG00000018092 | - | 100 | 100.000 | Chlorocebus_sabaeus |
ENSG00000005075 | POLR2J | 100 | 81.197 | ENSCING00000020531 | - | 100 | 81.197 | Ciona_intestinalis |
ENSG00000005075 | POLR2J | 100 | 81.197 | ENSCSAVG00000006948 | - | 100 | 81.197 | Ciona_savignyi |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSCGRG00001012814 | Polr2j | 100 | 100.000 | Cricetulus_griseus_chok1gshd |
ENSG00000005075 | POLR2J | 100 | 84.615 | ENSCGRG00000008433 | Polr2j | 100 | 84.615 | Cricetulus_griseus_crigri |
ENSG00000005075 | POLR2J | 100 | 94.017 | ENSCSEG00000020352 | polr2j | 100 | 94.017 | Cynoglossus_semilaevis |
ENSG00000005075 | POLR2J | 100 | 94.017 | ENSCVAG00000014267 | polr2j | 100 | 94.017 | Cyprinodon_variegatus |
ENSG00000005075 | POLR2J | 100 | 95.726 | ENSDARG00000035146 | polr2j | 100 | 95.726 | Danio_rerio |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSDORG00000005934 | Polr2j | 100 | 100.000 | Dipodomys_ordii |
ENSG00000005075 | POLR2J | 98 | 78.261 | FBgn0032634 | Rpb11 | 98 | 78.261 | Drosophila_melanogaster |
ENSG00000005075 | POLR2J | 100 | 64.103 | ENSEBUG00000016100 | polr2j | 100 | 64.103 | Eptatretus_burgeri |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSEASG00005016864 | - | 100 | 100.000 | Equus_asinus_asinus |
ENSG00000005075 | POLR2J | 100 | 95.726 | ENSELUG00000012822 | polr2j | 100 | 95.726 | Esox_lucius |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSFCAG00000000377 | - | 100 | 100.000 | Felis_catus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSFALG00000009523 | POLR2J | 100 | 100.000 | Ficedula_albicollis |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSFDAG00000010507 | - | 100 | 100.000 | Fukomys_damarensis |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSFHEG00000006625 | polr2j | 100 | 94.872 | Fundulus_heteroclitus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSGMOG00000018207 | polr2j | 100 | 94.872 | Gadus_morhua |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSGALG00000030808 | - | 100 | 100.000 | Gallus_gallus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSGAFG00000019555 | polr2j | 100 | 94.872 | Gambusia_affinis |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSGACG00000003310 | polr2j | 100 | 94.872 | Gasterosteus_aculeatus |
ENSG00000005075 | POLR2J | 97 | 90.265 | ENSGAGG00000018304 | - | 96 | 90.265 | Gopherus_agassizii |
ENSG00000005075 | POLR2J | 85 | 95.000 | ENSGGOG00000004519 | - | 80 | 95.000 | Gorilla_gorilla |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSHBUG00000008467 | polr2j | 100 | 94.872 | Haplochromis_burtoni |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSHGLG00000013598 | POLR2J | 100 | 100.000 | Heterocephalus_glaber_female |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSHGLG00100011242 | POLR2J | 100 | 100.000 | Heterocephalus_glaber_male |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSHCOG00000014827 | polr2j | 96 | 68.072 | Hippocampus_comes |
ENSG00000005075 | POLR2J | 100 | 96.581 | ENSIPUG00000023960 | polr2j | 100 | 96.581 | Ictalurus_punctatus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSSTOG00000006377 | POLR2J | 100 | 100.000 | Ictidomys_tridecemlineatus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSJJAG00000013854 | - | 100 | 100.000 | Jaculus_jaculus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSJJAG00000018834 | - | 100 | 94.872 | Jaculus_jaculus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSKMAG00000014581 | polr2j | 79 | 94.872 | Kryptolebias_marmoratus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSLBEG00000005885 | polr2j | 100 | 94.872 | Labrus_bergylta |
ENSG00000005075 | POLR2J | 100 | 96.581 | ENSLOCG00000001885 | polr2j | 89 | 96.581 | Lepisosteus_oculatus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSLAFG00000021507 | - | 100 | 100.000 | Loxodonta_africana |
ENSG00000005075 | POLR2J | 100 | 90.000 | ENSMMUG00000012019 | POLR2J | 100 | 90.000 | Macaca_mulatta |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSMAMG00000009374 | polr2j | 100 | 94.872 | Mastacembelus_armatus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSMZEG00005011932 | polr2j | 100 | 94.872 | Maylandia_zebra |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSMGAG00000003534 | POLR2J | 100 | 100.000 | Meleagris_gallopavo |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSMAUG00000013049 | Polr2j | 100 | 100.000 | Mesocricetus_auratus |
ENSG00000005075 | POLR2J | 80 | 95.745 | ENSMICG00000026811 | - | 95 | 94.792 | Microcebus_murinus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSMOCG00000001294 | Polr2j | 100 | 100.000 | Microtus_ochrogaster |
ENSG00000005075 | POLR2J | 100 | 94.017 | ENSMMOG00000013265 | polr2j | 100 | 94.017 | Mola_mola |
ENSG00000005075 | POLR2J | 100 | 91.406 | ENSMODG00000013617 | - | 100 | 91.406 | Monodelphis_domestica |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSMALG00000020749 | polr2j | 100 | 94.872 | Monopterus_albus |
ENSG00000005075 | POLR2J | 100 | 100.000 | MGP_CAROLIEiJ_G0027851 | Polr2j | 100 | 100.000 | Mus_caroli |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSMUSG00000039771 | Polr2j | 100 | 100.000 | Mus_musculus |
ENSG00000005075 | POLR2J | 100 | 100.000 | MGP_PahariEiJ_G0024434 | Polr2j | 100 | 100.000 | Mus_pahari |
ENSG00000005075 | POLR2J | 100 | 100.000 | MGP_SPRETEiJ_G0028853 | Polr2j | 100 | 100.000 | Mus_spretus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSMLUG00000010467 | POLR2J | 100 | 100.000 | Myotis_lucifugus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSNGAG00000023412 | Polr2j | 100 | 100.000 | Nannospalax_galili |
ENSG00000005075 | POLR2J | 66 | 90.909 | ENSNBRG00000006580 | polr2j | 59 | 92.105 | Neolamprologus_brichardi |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSODEG00000015648 | - | 100 | 100.000 | Octodon_degus |
ENSG00000005075 | POLR2J | 100 | 76.923 | ENSODEG00000008559 | - | 100 | 76.923 | Octodon_degus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSONIG00000000259 | polr2j | 100 | 94.872 | Oreochromis_niloticus |
ENSG00000005075 | POLR2J | 100 | 97.436 | ENSOANG00000020912 | POLR2J | 100 | 97.436 | Ornithorhynchus_anatinus |
ENSG00000005075 | POLR2J | 100 | 92.126 | ENSOCUG00000023609 | POLR2J | 100 | 92.126 | Oryctolagus_cuniculus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSORLG00000029046 | polr2j | 83 | 94.872 | Oryzias_latipes |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSORLG00020007625 | polr2j | 83 | 94.872 | Oryzias_latipes_hni |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSORLG00015003457 | polr2j | 83 | 94.872 | Oryzias_latipes_hsok |
ENSG00000005075 | POLR2J | 100 | 94.017 | ENSOMEG00000002097 | polr2j | 100 | 94.017 | Oryzias_melastigma |
ENSG00000005075 | POLR2J | 100 | 71.875 | ENSOGAG00000008250 | - | 100 | 71.875 | Otolemur_garnettii |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSOARG00000014204 | - | 98 | 100.000 | Ovis_aries |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSPPRG00000012439 | - | 100 | 100.000 | Panthera_pardus |
ENSG00000005075 | POLR2J | 97 | 91.228 | ENSPTIG00000018714 | - | 100 | 97.087 | Panthera_tigris_altaica |
ENSG00000005075 | POLR2J | 85 | 99.000 | ENSPSIG00000010173 | - | 100 | 99.000 | Pelodiscus_sinensis |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSPMGG00000021256 | polr2j | 100 | 94.872 | Periophthalmus_magnuspinnatus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSPEMG00000015733 | Polr2j | 100 | 100.000 | Peromyscus_maniculatus_bairdii |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSPCIG00000009026 | - | 100 | 100.000 | Phascolarctos_cinereus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSPFOG00000012001 | polr2j | 99 | 94.872 | Poecilia_formosa |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSPLAG00000014075 | polr2j | 100 | 94.872 | Poecilia_latipinna |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSPMEG00000020585 | polr2j | 100 | 94.872 | Poecilia_mexicana |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSPREG00000015255 | polr2j | 100 | 94.872 | Poecilia_reticulata |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSPCOG00000024573 | - | 100 | 100.000 | Propithecus_coquereli |
ENSG00000005075 | POLR2J | 99 | 93.966 | ENSPVAG00000017770 | - | 86 | 82.237 | Pteropus_vampyrus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSPNYG00000014832 | polr2j | 100 | 94.872 | Pundamilia_nyererei |
ENSG00000005075 | POLR2J | 100 | 94.017 | ENSPNAG00000016595 | polr2j | 100 | 94.017 | Pygocentrus_nattereri |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSRNOG00000001430 | Polr2j | 100 | 100.000 | Rattus_norvegicus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSSBOG00000025579 | - | 100 | 100.000 | Saimiri_boliviensis_boliviensis |
ENSG00000005075 | POLR2J | 59 | 100.000 | ENSSHAG00000010443 | - | 81 | 100.000 | Sarcophilus_harrisii |
ENSG00000005075 | POLR2J | 93 | 94.495 | ENSSFOG00015003371 | polr2j | 83 | 94.495 | Scleropages_formosus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSSMAG00000006729 | polr2j | 100 | 94.872 | Scophthalmus_maximus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSSDUG00000018490 | polr2j | 100 | 94.872 | Seriola_dumerili |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSSLDG00000022354 | polr2j | 100 | 94.872 | Seriola_lalandi_dorsalis |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSSPUG00000010802 | - | 100 | 100.000 | Sphenodon_punctatus |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSSPAG00000021953 | polr2j | 100 | 94.872 | Stegastes_partitus |
ENSG00000005075 | POLR2J | 100 | 82.906 | ENSSSCG00000003703 | - | 83 | 82.906 | Sus_scrofa |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSSSCG00000007688 | - | 100 | 100.000 | Sus_scrofa |
ENSG00000005075 | POLR2J | 85 | 99.000 | ENSTGUG00000004501 | - | 100 | 99.000 | Taeniopygia_guttata |
ENSG00000005075 | POLR2J | 59 | 100.000 | ENSTGUG00000004510 | - | 100 | 100.000 | Taeniopygia_guttata |
ENSG00000005075 | POLR2J | 100 | 95.726 | ENSTRUG00000020842 | polr2j | 100 | 95.726 | Takifugu_rubripes |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSTNIG00000002994 | polr2j | 100 | 94.872 | Tetraodon_nigroviridis |
ENSG00000005075 | POLR2J | 91 | 82.243 | ENSTBEG00000005797 | - | 76 | 78.151 | Tupaia_belangeri |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSUAMG00000011310 | - | 100 | 100.000 | Ursus_americanus |
ENSG00000005075 | POLR2J | 100 | 100.000 | ENSUMAG00000012594 | - | 100 | 100.000 | Ursus_maritimus |
ENSG00000005075 | POLR2J | 100 | 98.291 | ENSXETG00000001108 | polr2j | 100 | 98.291 | Xenopus_tropicalis |
ENSG00000005075 | POLR2J | 100 | 94.872 | ENSXMAG00000012422 | polr2j | 100 | 94.872 | Xiphophorus_maculatus |
Go ID | Go_term | PubmedID | Evidence | Category |
---|---|---|---|---|
GO:0000398 | mRNA splicing, via spliceosome | - | TAS | Process |
GO:0001055 | RNA polymerase II activity | 21873635. | IBA | Function |
GO:0003677 | DNA binding | - | IEA | Function |
GO:0003899 | DNA-directed 5'-3' RNA polymerase activity | 21873635. | IBA | Function |
GO:0005515 | protein binding | 10783144.21988832.25416956. | IPI | Function |
GO:0005634 | nucleus | 9852112. | IDA | Component |
GO:0005654 | nucleoplasm | - | TAS | Component |
GO:0005665 | RNA polymerase II, core complex | 21873635. | IBA | Component |
GO:0005665 | RNA polymerase II, core complex | 9852112. | IDA | Component |
GO:0006283 | transcription-coupled nucleotide-excision repair | - | TAS | Process |
GO:0006351 | transcription, DNA-templated | - | TAS | Process |
GO:0006366 | transcription by RNA polymerase II | 9852112. | IDA | Process |
GO:0006366 | transcription by RNA polymerase II | - | TAS | Process |
GO:0006367 | transcription initiation from RNA polymerase II promoter | - | TAS | Process |
GO:0006368 | transcription elongation from RNA polymerase II promoter | - | TAS | Process |
GO:0006370 | 7-methylguanosine mRNA capping | - | TAS | Process |
GO:0008543 | fibroblast growth factor receptor signaling pathway | - | TAS | Process |
GO:0016070 | RNA metabolic process | - | TAS | Process |
GO:0030275 | LRR domain binding | 10783144. | IPI | Function |
GO:0035019 | somatic stem cell population maintenance | - | TAS | Process |
GO:0042795 | snRNA transcription by RNA polymerase II | - | TAS | Process |
GO:0046983 | protein dimerization activity | - | IEA | Function |
GO:0050434 | positive regulation of viral transcription | - | TAS | Process |
GO:0060964 | regulation of gene silencing by miRNA | - | TAS | Process |