EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24491799CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy.Cancer Res2014 Apr 1Ding Ldoi: 10.1158/0008-5472.CAN-13-1659
28831000Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.Proc Natl Acad Sci U S A2017 Sep 5Hashwah Hdoi: 10.1073/pnas.1619555114
17434128Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.Mol Cell2007 Apr 13Huang WC-
16707484cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells.J Biol Chem2006 Jul 21Fu X-
12165799TNFalpha induces acetylation of p53 but attenuates its transcriptional activation in rheumatoid synoviocytes.Int J Mol Med2002 SepNakazawa M-
25294805Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers.Oncotarget2014 Oct 15Guo W-
12433930Inhibitory effect of AP-1 complex on 5-aminolevulinate synthase gene expression through sequestration of cAMP-response element protein (CRE)-binding protein (CBP) coactivator.J Biol Chem2003 Jan 24Guberman AS-
28069569The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma.Cancer Discov2017 MarZhang Jdoi: 10.1158/2159-8290.CD-16-1417
29170789CREBBP and p300 lysine acetyl transferases in the DNA damage response.Cell Mol Life Sci2018 AprDutto Idoi: 10.1007/s00018-017-2717-4
24551300Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.Int J Clin Exp Pathol2014 Jan 15Gao Y-
20859991Transcriptional coactivators p300 and CBP stimulate estrogen receptor-beta signaling and regulate cellular events in prostate cancer.Prostate2011 Mar 1Bouchal Jdoi: 10.1002/pros.21257
22174411Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced prostate cancer cells.J Biol Chem2012 Feb 3Ianculescu Idoi: 10.1074/jbc.M111.300194
26318425RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth.Oncotarget2015 Sep 29Qin Ydoi: 10.18632/oncotarget.4825.
12696060Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines.Genes Chromosomes Cancer2003 JunTillinghast GW-
15701835Mutations and deletions of the CBP gene in human lung cancer.Clin Cancer Res2005 Jan 15Kishimoto M-
27881443Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.Cold Spring Harb Perspect Med2017 Mar 1Attar Ndoi: 10.1101/cshperspect.a026534.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr163793581Missense_MutationnovelA341S0.3
BLCAchr163749626Splice_Siters200782888X1279_splice0.35
BLCAchr1638799335'UTRnovel0.5
BLCAchr163767749Nonsense_MutationNAS1074*0.08
BLCAchr163736147Nonsense_MutationNAY1539*0.55
BLCAchr163778044Missense_MutationNAV694L0.18
BLCAchr163774689Missense_MutationnovelM721I0.26
BLCAchr163731304Missense_MutationnovelS1687F0.39
BLCAchr163738650Missense_MutationNAD1435H0.31
BLCAchr163738617Missense_Mutationrs398124146R1446C0.21
BLCAchr163738605Frame_Shift_InsnovelY1450Efs*140.1
BLCAchr163736759Missense_MutationNAF1484S0.52
BLCAchr163770791Nonsense_MutationNAQ887*0.74
BLCAchr163770951SilentNAL833L0.71
BLCAchr163749670Missense_MutationnovelD1265H0.21
BLCAchr163758022Silentrs749030378P1132P0.11
BLCAchr163793500Nonsense_MutationnovelQ368*0.28
BLCAchr163745300SilentnovelH1297H0.27
BLCAchr163727745Silentrs144609433T2434T0.35
BLCAchr163773903Nonsense_MutationnovelQ771*0.13
BLCAchr163739684Nonsense_MutationNAR1392*0.44
BLCAchr163774684Nonsense_MutationnovelS723*0.48
BLCAchr163757878Missense_MutationnovelK1180N0.57
BLCAchr163738649Missense_Mutationrs200207299D1435G0.72
BLCAchr163850803Missense_MutationnovelG98C0.1
BLCAchr163850804SilentnovelQ97Q0.1
BLCAchr163738650Missense_MutationNAD1435H0.38
BLCAchr163778083Frame_Shift_InsnovelN681Efs*450.27
BLCAchr163727905Missense_MutationnovelG2381V0.29
BLCAchr163727906Missense_MutationnovelG2381C0.3
BLCAchr163729714Nonsense_MutationnovelS1778*0.36
BLCAchr163731374Missense_MutationNAR1664C0.36
BLCAchr163736649Splice_SitenovelX1520_splice0.25
BLCAchr163728455Frame_Shift_DelnovelR2194Cfs*1040.39
BLCAchr163778756Frame_Shift_DelnovelK622Wfs*20.29
BLCAchr163781262Nonsense_MutationNAQ540*0.3
BLCAchr163757991Missense_MutationNAD1143H0.23
BLCAchr163778128Missense_MutationNAE666Q0.62
BLCAchr163757964Nonsense_MutationNAQ1152*0.2
BLCAchr163767737Nonsense_MutationnovelS1078*0.27
BLCAchr163729152SilentNAE1965E0.25
BLCAchr163738652Missense_MutationnovelL1434R0.29
BLCAchr163736702Missense_Mutationrs587783497Y1503C0.35
BLCAchr163728369Silentrs750845399A2226A0.37
BLCAchr163778042SilentnovelV694V0.46
BLCAchr163729342Missense_MutationnovelT1902M0.44
BLCAchr163781262Nonsense_MutationNAQ540*0.33
BLCAchr163780775Nonsense_MutationNAE594*0.59
BLCAchr163769230Frame_Shift_DelnovelQ1002Kfs*200.38
BLCAchr163738616Missense_MutationNAR1446L0.33
BLCAchr163738646Missense_MutationNAS1436N0.77
BLCAchr163769200Missense_MutationNAE1012K0.37
BLCAchr163770784Nonsense_MutationNAS889*0.14
BLCAchr163736705Nonsense_MutationNAW1502*0.93
BLCAchr163729157Missense_MutationnovelR1964C0.4
BLCAchr163791996Nonsense_MutationnovelK439*0.24
BLCAchr163738616In_Frame_InsnovelL1445dup0.17
BLCAchr163770935Nonsense_MutationNAQ839*0.6
BLCAchr163749626Splice_Siters200782888X1279_splice0.33
BLCAchr163778053Nonsense_MutationnovelQ691*0.23
BLCAchr163850860Missense_Mutationrs752992134G79S0.24
BLCAchr163770719Nonsense_MutationNAQ911*0.45
BLCAchr163758852Splice_SitenovelX1123_splice0.26
BRCAchr163731802Missense_MutationNAY1622H0.44
BRCAchr163850660SilentnovelP145P0.41
BRCAchr163728244Missense_MutationNAM2268T0.16
BRCAchr163773823Frame_Shift_InsnovelN797Kfs*350.25
BRCAchr1637276333'UTRnovel0.13
BRCAchr163731405Missense_MutationnovelD1653E0.07
BRCAchr163738604Missense_MutationNAY1450C0.07
BRCAchr163729690Missense_MutationnovelR1786H0.19
BRCAchr163731888Missense_MutationNAT1593N0.42
BRCAchr163850735SilentNAK120K0.42
BRCAchr163758952Missense_MutationNAR1091C0.46
BRCAchr163727932Missense_MutationNAS2372L0.44
BRCAchr163850836Frame_Shift_InsnovelG87Pfs*280.61
BRCAchr163781216Frame_Shift_DelnovelL555Rfs*70.13
BRCAchr163728806Nonsense_MutationnovelQ2081*0.08
BRCAchr163773846Missense_MutationnovelQ790K0.16
BRCAchr163731301Missense_Mutationrs781364836T1688M0.19
BRCAchr163770608Missense_MutationnovelQ948K0.43
BRCAchr163728744Missense_MutationNAI2101M0.18
BRCAchr163739683Missense_MutationNAR1392Q0.12
BRCAchr163757913Missense_MutationNAR1169C0.19
BRCAchr163850517Missense_MutationNAS193C0.12
BRCAchr163745331Missense_MutationNAG1287D0.28
BRCAchr163777657Missense_MutationNAN705S0.29
BRCAchr163729529Missense_MutationnovelV1840L0.21
BRCAchr163729641SilentNAV1802V0.42
CESCchr163751795Missense_MutationNAC1237Y0.56
CESCchr163731374Missense_MutationNAR1664C0.6
CESCchr163736680Silentrs372936553A1510A0.16
CESCchr163736797Missense_MutationNAI1471M0.13
CESCchr163850458Missense_MutationNAL213F0.23
CESCchr163850421Missense_MutationNAP225L0.17
CESCchr163850883Missense_MutationNAS71L0.19
CESCchr163745275Splice_SitenovelX1305_splice0.67
CESCchr1637251373'UTRnovel0.31
CESCchr163778119Missense_MutationnovelR669W0.35
CESCchr163850709Missense_MutationNAS129L0.53
CESCchr163851000Missense_MutationNAS32L0.35
CESCchr163728904Frame_Shift_DelnovelV2048Gfs*270.14
CESCchr163767810Missense_MutationnovelE1054K0.32
CESCchr163744921Nonsense_MutationNAR1319*0.22
CESCchr163731862Missense_MutationNAR1602C0.11
CESCchr163729617Frame_Shift_DelnovelK1811Rfs*620.22
CESCchr163778739SilentnovelK634K0.31
CESCchr1637252133'UTRrs7719495370.44
CESCchr163728766Missense_MutationNAP2094L0.57
CESCchr163773805Silentrs139207930S803S0.44
CESCchr163850774Silentrs763083818P107P0.34
CESCchr163729770SilentNAP1759P0.31
CESCchr163751725Splice_Siters587783483X1260_splice0.64
CESCchr163738617Missense_Mutationrs398124146R1446C0.52
CESCchr163778775SilentnovelK622K0.11
CESCchr163736137Missense_MutationNAD1543H0.41
CESCchr1637272073'UTRnovel0.44
CESCchr1637266743'UTRnovel0.73
CESCchr163757953SilentnovelD1155D0.17
CESCchr163773803Missense_MutationnovelG804V0.35
CESCchr163749624Splice_Regionnovel0.41
CESCchr163738559Missense_MutationnovelG1465E0.53
CESCchr163749670Frame_Shift_DelnovelD1265Ifs*110.36
CESCchr163850913Missense_MutationNAP61L0.34
CESCchr163736747Missense_MutationNAP1488R0.23
COADchr163770934Missense_MutationNAQ839R0.27
COADchr163792082Missense_MutationNAA410V0.32
COADchr1637275643'UTRnovel0.32
COADchr163731826Missense_MutationNAS1614P0.38
COADchr163739692Missense_MutationNAF1389S0.35
COADchr163850825Silentrs748030826S90S0.33
COADchr163767719Frame_Shift_InsNAI1084Nfs*30.19
COADchr163731471Splice_RegionNAV1631V0.83
COADchr163738617Missense_Mutationrs398124146R1446C0.3
COADchr163778174Nonsense_MutationnovelY650*0.19
COADchr163791992Missense_MutationnovelR440Q0.24
COADchr163850434Missense_MutationnovelG221R0.2
COADchr163778718Silentrs763196598Y641Y0.39
COADchr163757911SilentNAR1169R0.19
COADchr163738671Missense_MutationnovelR1428C0.24
COADchr163793454Missense_MutationnovelP383L0.23
COADchr163758946Missense_MutationnovelA1093T0.35
COADchr163774674Silentrs151083156P726P0.28
COADchr163731300SilentNAT1688T0.51
COADchr163727958Silentrs199610814P2363P0.08
COADchr163757925Missense_MutationNAW1165R0.33
COADchr163727816Frame_Shift_DelNAQ2411Sfs*20.24
COADchr163729843Missense_MutationNAT1735M0.38
COADchr163774693Missense_MutationnovelG720V0.28
COADchr163769309Frame_Shift_DelNAS976Pfs*220.09
COADchr163729623Nonsense_MutationNAC1808*0.42
COADchr163774574Missense_MutationnovelP760S0.21
COADchr163745309SilentNAC1294C0.34
COADchr163767720Frame_Shift_DelNAI1084Sfs*150.26
COADchr163778183Splice_SiteNAX648_splice0.31
COADchr163739645Missense_Mutationrs140133512V1405M0.33
COADchr163731316Missense_MutationnovelR1683H0.37
COADchr163850739Missense_MutationNAG119V0.43
COADchr163731796Missense_MutationnovelT1624P0.35
COADchr163728832Missense_MutationNAR2072Q0.38
COADchr163728419Nonsense_MutationnovelQ2210*0.15
COADchr163729089Silentrs774747147T1986T0.1
COADchr163731379Missense_MutationnovelD1662G0.13
COADchr163729691Missense_MutationNAR1786C0.17
COADchr163729828Missense_MutationNAH1740R0.32
COADchr163731277Missense_MutationNAH1696R0.34
COADchr163810744Missense_MutationnovelQ278H0.06
COADchr163728975Silentrs201934909A2024A0.2
COADchr163782828Missense_MutationnovelD477N0.18
COADchr163727958Silentrs199610814P2363P0.1
COADchr163767720Frame_Shift_DelNAI1084Sfs*150.27
COADchr163793459Silentrs147342740S381S0.15
COADchr163728451Missense_Mutationrs765821935Q2199L0.27
COADchr163729277Missense_Mutationrs368145743V1924M0.24
COADchr163728596Missense_MutationNAR2151W0.31
COADchr163729308Silentrs777139307P1913P0.12
COADchr163729533SilentnovelC1838C0.29
COADchr163727975Missense_MutationnovelP2358S0.08
COADchr163773906Missense_MutationnovelP770S0.44
COADchr1637276833'UTRnovel0.29
COADchr163778113Missense_MutationnovelS671P0.32
COADchr163780754Missense_MutationNAR601W0.25
COADchr163740469Missense_Mutationrs774076896G1355R0.48
COADchr163757913Missense_MutationNAR1169C0.22
COADchr163850429Silentrs772743817A222A0.18
COADchr1637276153'UTRnovel0.19
COADchr163728042Silentrs751640745I2335I0.07
COADchr163738616Missense_MutationNAR1446H0.32
COADchr163778112Missense_MutationNAS671L0.03
COADchr163850696SilentnovelL133L0.53
COADchr163758018In_Frame_InsnovelM1133_D1134insLK0.07
COADchr1638800335'UTRnovel0.31
COADchr163728361Missense_MutationnovelG2229D0.35
COADchr163770933Missense_MutationNAQ839H0.18
COADchr163731853Missense_MutationnovelK1605E0.23
COADchr163767720Frame_Shift_DelNAI1084Sfs*150.25
DLBCchr163736763Missense_MutationNAI1483F0.23
DLBCchr163778720Missense_MutationnovelY641H0.4
DLBCchr163739635Missense_MutationNAC1408Y0.43
DLBCchr163739596Missense_MutationnovelC1421F0.63
ESCAchr163793430Missense_MutationnovelV391A0.1
ESCAchr163850660Frame_Shift_DelnovelA146Lfs*60.11
ESCAchr163738616Missense_MutationNAR1446L0.35
ESCAchr163731438SilentnovelV1642V0.3
ESCAchr163728028Missense_MutationnovelS2340N0.06
ESCAchr163774635Missense_MutationnovelM739I0.13
ESCAchr1637275673'UTRnovel0.27
ESCAchr163757901Nonsense_MutationNAR1173*0.24
ESCAchr163736137Missense_MutationNAD1543H0.25
ESCAchr163778083Frame_Shift_InsnovelN681Efs*450.31
ESCAchr163770587Nonsense_MutationNAQ955*0.83
ESCAchr163739595Nonsense_MutationnovelC1421*0.15
GBMchr163780733Missense_MutationnovelL608V0.16
GBMchr163781234Nonsense_MutationnovelS549*0.12
GBMchr163850432SilentnovelG221G0.31
GBMchr163731902Missense_MutationnovelK1588N0.47
GBMchr163793502Missense_MutationnovelC367S0.03
GBMchr163792055Nonsense_MutationNAW419*0.27
GBMchr163780825Missense_MutationnovelI577K0.05
GBMchr163728851Missense_MutationnovelA2066T0.3
GBMchr163778125Missense_MutationnovelE667K0.18
GBMchr163850986Missense_MutationnovelE37K0.22
GBMchr163769270SilentnovelP988P0.15
GBMchr163770907Missense_MutationnovelV848G0.31
GBMchr163731354Silentrs62037853L1670L0.73
GBMchr163744957Missense_Mutationrs751602717V1307M0.03
GBMchr163729061Missense_MutationNAA1996T0.78
GBMchr163757977Nonsense_MutationnovelY1147*0.09
GBMchr163793445Frame_Shift_DelnovelR386Qfs*30.06
GBMchr163738616Missense_MutationNAR1446H0.4
HNSCchr163729590Nonsense_MutationNAC1819*0.23
HNSCchr163739615Nonsense_MutationNAQ1415*0.11
HNSCchr163770791Nonsense_MutationNAQ887*0.05
HNSCchr163729765Nonsense_MutationNAS1761*0.21
HNSCchr163729595Missense_MutationnovelV1818L0.09
HNSCchr163736673Missense_MutationnovelE1513K0.13
HNSCchr163739609Missense_MutationnovelY1417H0.43
HNSCchr163778019Missense_MutationnovelR702T0.17
HNSCchr163738662Missense_MutationnovelI1431V0.34
HNSCchr163740494Frame_Shift_InsnovelL1346Ffs*80.27
HNSCchr163770640Frame_Shift_Delrs797045485P937Rfs*610.26
HNSCchr163727766Silentrs764396354V2427V0.21
HNSCchr163738617Missense_Mutationrs398124146R1446C0.37
HNSCchr163780808Missense_MutationnovelP583S0.11
HNSCchr163770843Silentrs375527347L869L0.12
HNSCchr163728855SilentnovelP2064P0.36
HNSCchr163728358Missense_MutationnovelQ2230L0.5
HNSCchr163731464Missense_MutationnovelV1634L0.88
HNSCchr163738644Missense_MutationNAI1437F0.12
HNSCchr163738645Missense_MutationnovelS1436R0.15
HNSCchr163731356Missense_MutationnovelL1670F0.31
HNSCchr163731357SilentnovelT1669T0.31
HNSCchr163729446SilentnovelR1867R0.15
HNSCchr163850962Missense_MutationnovelI45V0.16
HNSCchr163751776Missense_MutationnovelE1243D0.23
HNSCchr163738617Missense_Mutationrs398124146R1446C0.24
HNSCchr163769249SilentnovelL995L0.22
HNSCchr163850761Missense_MutationnovelM112V0.29
HNSCchr163736769Missense_MutationnovelD1481N0.17
HNSCchr163731252SilentnovelV1704V0.19
HNSCchr163793539Frame_Shift_InsnovelQ355Tfs*120.51
HNSCchr163729047SilentnovelL2000L0.62
HNSCchr163769188Nonsense_MutationnovelE1016*0.22
HNSCchr163767903Missense_MutationnovelE1023K0.15
HNSCchr163740492Missense_MutationnovelR1347Q0.27
HNSCchr163770571Missense_MutationnovelP960R0.2
HNSCchr163738604Missense_MutationNAY1450C0.86
HNSCchr163736794Missense_MutationNAW1472C0.28
HNSCchr163739596Missense_MutationnovelC1421F0.18
HNSCchr163778789Missense_MutationnovelP618T0.32
HNSCchr163731793Missense_MutationNAM1625V0.69
HNSCchr163731825Missense_MutationnovelS1614F0.26
KIRCchr163740478Missense_MutationnovelP1352T0.37
KIRCchr163793625Missense_MutationNAS326F0.22
KIRCchr1637275753'UTRnovel0.44
KIRPchr163767822Nonsense_MutationNAE1050*0.28
KIRPchr163810636SilentNAI314I0.34
KIRPchr163729273Missense_MutationnovelA1925G0.2
KIRPchr163728973Missense_MutationnovelP2025H0.26
KIRPchr163810644Missense_Mutationrs764674912T312A0.3
KIRPchr163729017SilentNAG2010G0.35
KIRPchr163851000Missense_MutationNAS32L0.28
KIRPchr163757906Missense_MutationNAT1171I0.28
LAMLchr163850731Missense_MutationnovelP122T0.06
LAMLchr163757937Missense_MutationnovelF1161I0.42
LAMLchr163770975SilentnovelP825P0.11
LGGchr163731316Missense_MutationNAR1683P0.64
LGGchr163778794Frame_Shift_DelnovelP616Lfs*60.36
LGGchr1637276223'UTRrs7776252620.46
LGGchr163731929Missense_MutationnovelQ1579H0.12
LGGchr163736040Missense_MutationnovelT1575N0.11
LGGchr163738663SilentnovelY1430Y0.52
LGGchr163767887Missense_MutationnovelG1028E0.35
LGGchr163793550Missense_Mutationrs763070109R351H0.44
LGGchr163879832Missense_MutationnovelD29Y0.54
LGGchr163731374Missense_MutationNAR1664C0.35
LIHCchr163780771Missense_MutationNAH595R0.23
LIHCchr163810605Missense_Mutationrs747990896M325L0.4
LIHCchr163728016Missense_Mutationrs753595183R2344Q0.46
LIHCchr163757811Nonsense_MutationnovelK1203*0.41
LIHCchr163757291Missense_MutationNAN1232S0.37
LIHCchr163793531SilentnovelQ357Q0.46
LIHCchr163728619Missense_MutationNAN2143S0.25
LUADchr163727846Missense_MutationNAG2401W0.35
LUADchr163745337Missense_MutationnovelE1285G0.36
LUADchr163793415Missense_MutationNAT396R0.31
LUADchr163731861Missense_MutationnovelR1602L0.1
LUADchr163731862Missense_MutationNAR1602C0.1
LUADchr163729781Nonsense_MutationNAQ1756*0.4
LUADchr163850687Missense_MutationNAQ136H0.45
LUADchr163781291Missense_MutationnovelN530I0.09
LUADchr163850442Missense_MutationnovelR218I0.3
LUADchr163728777SilentnovelL2090L0.35
LUADchr163770747SilentnovelP901P0.19
LUADchr163810675Missense_MutationNAQ301H0.47
LUADchr163728084SilentnovelL2321L0.4
LUADchr163757316Missense_MutationnovelD1224Y0.32
LUADchr163767810Missense_MutationnovelE1054K0.19
LUADchr163728144Missense_MutationnovelM2301I0.1
LUADchr163727989Missense_MutationnovelR2353L0.28
LUADchr163850575Missense_MutationNAG174R0.35
LUADchr163729423Missense_MutationNAR1875L0.25
LUADchr163731235Missense_MutationNAC1710S0.1
LUADchr163736753Frame_Shift_DelnovelC1486Pfs*40.04
LUADchr163731337Frame_Shift_InsnovelW1676Lfs*590.23
LUADchr163729778Missense_MutationNAG1757C0.24
LUADchr163731194Missense_MutationNAE1724K0.18
LUADchr163739612Missense_MutationNAE1416Q0.22
LUADchr163781212SilentnovelG556G0.73
LUADchr163793557Nonsense_MutationnovelE349*0.2
LUADchr163757899SilentnovelR1173R0.19
LUADchr163728568Missense_Mutationrs779980394A2160V0.29
LUADchr163736794Missense_MutationNAW1472C0.17
LUADchr163740431Missense_MutationNAK1367N0.15
LUSCchr163728372Missense_MutationnovelM2225I0.19
LUSCchr163773883SilentNAG777G0.33
LUSCchr163793454Missense_MutationNAP383R0.26
LUSCchr163778021SilentNAV701V0.57
LUSCchr163738617Missense_Mutationrs398124146R1446C0.11
LUSCchr163778794Missense_MutationNAP616R0.3
LUSCchr163729577Missense_MutationNAA1824T0.12
LUSCchr163757794Splice_SitenovelX1202_splice0.36
LUSCchr163773773Missense_MutationNAP814L0.67
LUSCchr163738650Missense_MutationNAD1435Y0.2
LUSCchr163770762SilentnovelG896G0.41
LUSCchr163727893Missense_MutationnovelP2385L0.55
LUSCchr163738616Missense_MutationNAR1446H0.64
LUSCchr163778704Missense_MutationnovelS646I0.62
LUSCchr163728058Missense_MutationNAL2330R0.61
LUSCchr163773768Frame_Shift_DelnovelQ816Kfs*330.3
LUSCchr163773769SilentnovelA815A0.3
LUSCchr163850413Missense_MutationNAT228A0.29
LUSCchr163736660Missense_MutationnovelH1517L0.16
LUSCchr163738605Missense_MutationNAY1450D0.38
LUSCchr163850296Splice_SitenovelX266_splice0.12
LUSCchr163757900Missense_MutationnovelR1173Q0.95
LUSCchr163739635Missense_MutationNAC1408Y0.1
LUSCchr163729745Missense_MutationnovelR1768C0.31
LUSCchr163757999Missense_MutationNAR1140Q0.48
LUSCchr163728104Missense_MutationNAS2315C0.13
LUSCchr163729747Missense_MutationNAS1767L0.13
LUSCchr163736794Missense_MutationNAW1472C0.43
LUSCchr163736817Splice_SitenovelX1465_splice0.27
LUSCchr163769309Frame_Shift_DelNAS976Pfs*220.14
LUSCchr163731464Frame_Shift_DelnovelF1633Dfs*250.46
LUSCchr163744897Nonsense_MutationNAK1327*0.21
LUSCchr163739626Missense_Mutationrs201186078G1411E0.9
LUSCchr163745298Missense_MutationNAY1298C0.21
LUSCchr163728555SilentnovelL2164L0.29
LUSCchr163810666SilentnovelV304V0.11
LUSCchr163744951Missense_MutationnovelD1309H0.3
LUSCchr163850302Missense_Mutationrs753319377A265T0.63
LUSCchr163782750Nonsense_MutationNAQ503*0.32
LUSCchr163728918Missense_MutationnovelQ2043H0.3
LUSCchr163727895Missense_MutationNAH2384Q0.17
MESOchr163736771Missense_MutationnovelD1480G0.32
MESOchr163728927SilentnovelI2040I0.3
OVchr163770935Frame_Shift_DelNAG837Rfs*100.78
OVchr163810720Missense_MutationNAQ286H0.37
OVchr163751728Frame_Shift_DelnovelG1252Dfs*90.15
OVchr163850378SilentnovelL239L0.04
OVchr163745332Missense_MutationnovelG1287R0.39
OVchr163767911Splice_SiteNAX1021_splice0.65
OVchr163745267Splice_SiteNAX1304_splice0.4
OVchr163810725Frame_Shift_InsnovelG285Sfs*670.43
OVchr163728294Missense_MutationnovelQ2251H0.29
OVchr163738595Missense_MutationNAI1453T0.12
OVchr163780804Frame_Shift_DelnovelS584Lfs*50.04
OVchr163793432Missense_MutationNAN390K0.55
OVchr163728790Missense_MutationnovelV2086E0.14
OVchr163728791Missense_MutationnovelV2086L0.12
OVchr163769344Missense_MutationnovelA964P0.11
OVchr163736809SilentNAV1467V0.36
OVchr163728513Missense_MutationnovelH2178Q0.08
OVchr163739577Splice_SiteNAX1427_splice0.34
OVchr163782825Missense_MutationnovelP478S0.06
OVchr163793390SilentnovelC404C0.04
OVchr163740519Missense_MutationNAL1338S0.2
PAADchr163751766Missense_MutationnovelE1247K0.2
PAADchr163773808Silentrs748195458S802S0.2
PAADchr163728861Silentrs780383901I2062I0.06
PAADchr163757334Missense_MutationnovelL1218M0.18
PCPGchr163727927Frame_Shift_DelnovelH2374Tfs*220.05
PRADchr163731217Missense_MutationNAT1716M0.17
PRADchr163728438Frame_Shift_DelnovelQ2199Hfs*990.32
PRADchr163728980Missense_MutationnovelQ2023E0.5
PRADchr163728252Silentrs748072121A2265A0.48
PRADchr163729040Missense_MutationnovelP2003S0.46
PRADchr163729686Silentrs375462934N1787N0.42
PRADchr163757827SilentnovelG1197G0.41
PRADchr163782870Missense_MutationnovelG463W0.35
READchr163749631Missense_Mutationrs267606752E1278K0.25
READchr163778134Nonsense_MutationNAE664*0.24
READchr163850883Missense_MutationNAS71L0.48
READchr163728017Missense_MutationNAR2344W0.11
READchr163770702SilentnovelP916P0.39
READchr163778110Missense_MutationnovelR672C0.38
READchr163751730Nonsense_MutationNAQ1259*0.38
READchr163767720Frame_Shift_DelNAI1084Sfs*150.31
READchr163739725Splice_SiteNAX1378_splice0.2
READchr1637275833'UTRnovel0.48
READchr163729577Missense_MutationNAA1824T0.4
READchr163850859Missense_MutationnovelG79V0.39
READchr163810668Missense_Mutationrs766101764V304I0.2
READchr163810675SilentnovelQ301Q0.35
READchr163729419Silentrs747210551N1876N0.15
SARCchr163728376Missense_MutationnovelG2224D0.07
SARCchr163769195Frame_Shift_DelnovelE1016Sfs*60.18
SARCchr163782701Missense_MutationnovelR519K0.35
SARCchr163850552Frame_Shift_DelnovelF181Lfs*170.53
SKCMchr163751794Missense_MutationnovelC1237W0.23
SKCMchr163728042Silentrs751640745I2335I0.3
SKCMchr163727902Missense_MutationnovelS2382F0.1
SKCMchr163850837SilentNAI86I0.32
SKCMchr163728811Missense_MutationnovelS2079F0.29
SKCMchr163739703Missense_MutationnovelM1385I0.25
SKCMchr163769318SilentnovelV972V0.26
SKCMchr163745307Missense_MutationNAV1295A0.2
SKCMchr163810726SilentNAG284G0.45
SKCMchr163777649SilentNAL708L0.52
SKCMchr163739591Missense_Mutationrs797045493P1423S0.21
SKCMchr163769271Missense_MutationNAP988L0.06
SKCMchr163727935Missense_MutationNAP2371L0.11
SKCMchr163740454Nonsense_Mutationrs587783490R1360*0.11
SKCMchr163745351SilentNAF1280F0.29
SKCMchr163810647Missense_MutationNAP311S0.29
SKCMchr163727980Missense_MutationNAS2356F0.12
SKCMchr163778795Missense_MutationNAP616S0.35
SKCMchr163727912Nonsense_MutationnovelQ2379*0.42
SKCMchr163810636SilentNAI314I0.4
SKCMchr163727724Silentrs374635162G2441G0.46
SKCMchr163769271Missense_MutationNAP988L0.46
SKCMchr163736112Missense_MutationNAE1551G0.2
SKCMchr163738569Missense_MutationnovelK1462E0.23
SKCMchr163850297Splice_RegionNAK266K0.13
SKCMchr163792065Missense_MutationNAI416V0.27
SKCMchr163728283Missense_MutationNAP2255L0.28
SKCMchr163774616Missense_MutationNAP746S0.15
SKCMchr163728992Missense_MutationNAG2019W0.58
SKCMchr163850526Missense_MutationNAN190I0.28
SKCMchr163778032Missense_MutationnovelA698T0.17
SKCMchr163778033SilentnovelQ697Q0.17
SKCMchr163727766Silentrs764396354V2427V0.39
SKCMchr163778060Silentrs766050154P688P0.27
SKCMchr163727961Silentrs561341822S2362S0.41
SKCMchr163729714Missense_MutationNAS1778L0.16
SKCMchr163850704Missense_MutationNAP131S0.1
SKCMchr163744897Nonsense_MutationNAK1327*0.47
SKCMchr163744930Missense_Mutationrs776643295G1316S0.27
SKCMchr163728056Missense_MutationnovelP2331S0.16
SKCMchr163728736Missense_MutationNAR2104P0.1
SKCMchr163758894Missense_MutationNAP1110R0.23
SKCMchr163738617Missense_Mutationrs398124146R1446C0.23
SKCMchr163736778Missense_MutationNAE1478K0.44
SKCMchr163778112Missense_MutationNAS671L0.28
SKCMchr163770652Missense_MutationnovelP933L0.34
SKCMchr163728064Missense_MutationNAS2328L0.43
SKCMchr163770668Missense_MutationNAP928S0.52
SKCMchr163751750Missense_MutationnovelG1252D0.55
SKCMchr163850704Missense_MutationNAP131S0.43
SKCMchr1637276943'UTRnovel0.62
SKCMchr163729524SilentnovelP1841P0.43
SKCMchr163738597SilentnovelE1452E0.57
SKCMchr163782834Missense_MutationNAP475S0.34
STADchr163731861Missense_MutationnovelR1602H0.16
STADchr163850560Missense_Mutationrs758740001A179T0.2
STADchr163729643Missense_MutationNAV1802M0.08
STADchr163793433Frame_Shift_DelnovelN390Tfs*30.41
STADchr163727897Frame_Shift_DelNAH2384Tfs*120.3
STADchr163728852Silentrs374150949S2065S0.08
STADchr163729496Missense_MutationnovelR1851S0.09
STADchr163740493Missense_MutationNAR1347W0.14
STADchr163773776Missense_Mutationrs150767375P813L0.21
STADchr163774614Frame_Shift_InsNAM747Nfs*850.15
STADchr163731464Missense_MutationNAV1634M0.6
STADchr163738616Missense_MutationNAR1446H0.23
STADchr163850659Frame_Shift_InsnovelA146Rfs*190.06
STADchr163728386Missense_MutationNAM2221V0.29
STADchr163727969In_Frame_DelnovelP2359del0.38
STADchr163778748SilentNAA631A0.21
STADchr163731198SilentNAV1722V0.3
STADchr163770835Missense_Mutationrs747877878T872M0.29
STADchr163757912Missense_MutationNAR1169H0.42
STADchr163728007Missense_Mutationrs182347573A2347V0.45
STADchr163728765Silentrs772950054P2094P0.41
STADchr163736096Silentrs749565984L1556L0.47
STADchr163729596Silentrs373848722P1817P0.22
STADchr163728616Missense_MutationNAA2144V0.1
STADchr163793432SilentNAN390N0.08
STADchr163731416Missense_Mutationrs776549587V1650I0.42
STADchr163850609Silentrs753948670A162A0.4
STADchr163767720Frame_Shift_DelNAI1084Sfs*150.28
STADchr163731889Frame_Shift_DelnovelT1593Pfs*420.38
STADchr163736680Silentrs372936553A1510A0.25
STADchr163767720Frame_Shift_DelNAI1084Sfs*150.43
STADchr163770834Silentrs781112420T872T0.28
STADchr163757912Missense_MutationNAR1169H0.69
STADchr163728017Missense_MutationNAR2344W0.08
STADchr163736718Nonsense_MutationNAR1498*0.05
STADchr163727886SilentNAL2387L0.27
STADchr163728281Frame_Shift_DelnovelL2256Sfs*460.45
STADchr163731301Missense_Mutationrs781364836T1688M0.13
STADchr163736654Missense_MutationNAY1519C0.36
STADchr163758952Missense_MutationNAR1091C0.2
STADchr163850420Silentrs140708841P225P0.24
STADchr163736798Missense_MutationNAI1471N0.18
STADchr163728833Missense_MutationNAR2072W0.46
STADchr163731862Missense_MutationNAR1602C0.43
STADchr163731926Silentrs563033919G1580G0.23
STADchr163767719Frame_Shift_InsNAI1084Nfs*30.2
STADchr163739628Frame_Shift_DelnovelF1410Lfs*490.38
STADchr163767719Frame_Shift_InsNAI1084Nfs*30.27
STADchr163770607Missense_MutationNAQ948R0.26
STADchr163745298Missense_MutationNAY1298C0.24
STADchr163749627Missense_Mutationrs749189606P1279L0.44
STADchr163770944Missense_MutationNAL836M0.18
STADchr163774573Missense_MutationNAP760Q0.06
STADchr163727762Missense_MutationNAD2429N0.12
STADchr163740454Nonsense_Mutationrs587783490R1360*0.1
STADchr163736140Missense_MutationNAG1542S0.2
STADchr163778787Silentrs61754522P618P0.25
STADchr163767720Frame_Shift_DelNAI1084Sfs*150.25
STADchr163793415Missense_MutationNAT396M0.21
STADchr163728705SilentNAG2114G0.29
STADchr163728451Missense_Mutationrs765821935Q2199L0.09
STADchr163731372Silentrs756979739R1664R0.33
STADchr163767720Frame_Shift_DelNAI1084Sfs*150.33
STADchr163729496Missense_Mutationrs763253161R1851C0.44
TGCTchr163780850Missense_MutationnovelG569S0.12
TGCTchr163850552Frame_Shift_DelnovelF181*0.26
THCAchr163774690Frame_Shift_InsnovelM721Tfs*20.09
THCAchr163778106Nonsense_MutationNAL673*0.06
UCECchr163778109Missense_MutationNAR672H0.51
UCECchr163729744Frame_Shift_DelnovelR1768Pfs*30.48
UCECchr163729746Frame_Shift_DelnovelR1768Afs*30.5
UCECchr163738616Missense_MutationNAR1446H0.06
UCECchr163810700Missense_MutationnovelV293E0.03
UCECchr163740498Missense_MutationNAF1345C0.37
UCECchr163770742Missense_MutationNAP903H0.09
UCECchr163728807Frame_Shift_InsnovelQ2081Sfs*2600.39
UCECchr163728634Missense_MutationnovelS2138I0.3
UCECchr163729035SilentnovelR2004R0.48
UCECchr163736170Missense_MutationnovelT1532A0.12
UCECchr163782729Missense_MutationnovelA510S0.13
UCECchr163728766Missense_MutationNAP2094L0.52
UCECchr163738616Missense_MutationNAR1446H0.09
UCECchr163767798Nonsense_MutationNAE1058*0.08
UCECchr1637267683'UTRnovel0.28
UCECchr163780843Missense_MutationnovelI571S0.4
UCECchr163728737Missense_MutationNAR2104C0.28
UCECchr163736731In_Frame_DelnovelI1493del0.39
UCECchr1637267063'UTRnovel0.14
UCECchr163773914Missense_MutationnovelS767F0.15
UCECchr163773920Missense_MutationNAS765Y0.37
UCECchr163774601Missense_MutationnovelV751I0.41
UCECchr163729036Missense_MutationnovelR2004Q0.33
UCECchr163769302Missense_MutationnovelV978M0.31
UCECchr163850308Missense_MutationnovelG263C0.4
UCECchr163850774Silentrs763083818P107P0.52
UCECchr163729818SilentnovelV1743V0.19
UCECchr163736173Missense_MutationnovelL1531F0.41
UCECchr163727995Missense_MutationnovelS2351F0.41
UCECchr163728166Missense_MutationnovelR2294Q0.35
UCECchr1638799295'UTRnovel0.55
UCECchr1637251893'UTRnovel0.14
UCECchr163728098Missense_MutationNAQ2317K0.27
UCECchr163731240Silentrs775433053N1708N0.24
UCECchr163731805Missense_MutationnovelL1621M0.05
UCECchr163739607Nonsense_MutationNAY1417*0.16
UCECchr163757983Silentrs372055982G1145G0.29
UCECchr163770877Missense_MutationNAP858L0.11
UCECchr163850363Silentrs374065235T244T0.21
UCECchr163727855Nonsense_MutationNAG2398*0.31
UCECchr163850320Missense_MutationNAA259T0.38
UCECchr163731860SilentnovelR1602R0.09
UCECchr163758902SilentNAE1107E0.12
UCECchr163728498SilentnovelA2183A0.5
UCECchr163729349Missense_MutationNAP1900A0.39
UCECchr163767856Missense_MutationNAI1038M0.32
UCECchr163729405Missense_MutationnovelS1881N0.21
UCECchr163736178Missense_MutationnovelD1529V0.17
UCECchr163757896SilentnovelV1174V0.25
UCECchr163781282Missense_MutationnovelA533V0.17
UCECchr163850351Silentrs768197650P248P0.45
UCECchr163767720Frame_Shift_DelNAI1084Sfs*150.08
UCECchr163729668Frame_Shift_DelnovelN1789Ifs*1720.38
UCECchr163731372Silentrs756979739R1664R0.78
UCECchr1637273503'UTRnovel0.5
UCECchr163850714SilentnovelD127D0.1
UCECchr163778119Missense_MutationnovelR669W0.36
UCECchr163727719Nonstop_Mutationnovel*2443Wext*230.06
UCECchr163740540Missense_MutationnovelT1331I0.27
UCECchr163757953SilentnovelD1155D0.36
UCECchr163770778Missense_MutationnovelP891L0.36
UCECchr1637265643'UTRnovel0.47
UCECchr1637271013'UTRnovel0.32
UCECchr163728370Missense_Mutationrs754601626A2226V0.53
UCECchr163728723Silentrs199821421Y2108Y0.36
UCECchr163731320Missense_Mutationrs200112956R1682C0.35
UCECchr163731863Silentrs754454362S1601S0.37
UCECchr163773800Missense_MutationnovelA805V0.49
UCECchr163778138SilentnovelQ662Q0.45
UCECchr163850363Silentrs374065235T244T0.35
UCECchr163850915SilentnovelV60V0.14
UCECchr163778110Missense_MutationnovelR672C0.34
UCECchr163781211Frame_Shift_Delrs398124139A557Pfs*50.39
UCECchr163736104Missense_MutationnovelK1554Q0.47
UCECchr1637265263'UTRnovel0.11
UCECchr1637252903'UTRnovel0.44
UCECchr163744952Silentrs146817265C1308C0.4
UCECchr163749681Missense_MutationnovelT1261I0.37
UCECchr163773854Missense_Mutationrs117910358A787V0.57
UCECchr163850888Missense_MutationnovelQ69H0.43
UCECchr1637266423'UTRnovel0.44
UCECchr163728034Missense_MutationnovelS2338F0.48
UCECchr163731374Missense_MutationNAR1664C0.45
UCECchr163731798Missense_MutationnovelA1623V0.12
UCECchr163777631Missense_Mutationrs751540839R714C0.31
UCECchr1637251423'UTRnovel0.66
UCECchr163850774Silentrs763083818P107P0.34
UCECchr163774646Nonsense_MutationnovelQ736*0.36
UCECchr163731859Missense_Mutationrs375557093A1603T0.45
UCECchr163770639Silentrs146168040P937P0.35
UCECchr163728705SilentNAG2114G0.63
UCECchr163728623Missense_MutationNAL2142M0.28
UCECchr163729820Missense_MutationnovelV1743M0.06
UCECchr163731463Missense_MutationNAV1634A0.28
UCECchr163739647Missense_MutationNAG1404V0.46
UCECchr1637267063'UTRnovel0.33
UCECchr1637268723'UTRnovel0.31
UCECchr163767719Frame_Shift_InsNAI1084Nfs*30.13
UCECchr163767720Frame_Shift_DelNAI1084Sfs*150.22
UCECchr163774628Missense_Mutationrs778882385R742C0.4
UCECchr163738642Missense_MutationNAI1437M0.3
UCECchr1637269313'UTRnovel0.27
UCECchr163738636Missense_MutationNAF1439L0.13
UCECchr163782809Missense_MutationnovelR483Q0.11
UCECchr1637275583'UTRnovel0.22
UCECchr163728921Missense_MutationnovelM2042I0.33
UCECchr163731926Silentrs563033919G1580G0.39
UCECchr163850825Silentrs748030826S90S0.46
UCECchr163729808Frame_Shift_InsnovelL1747Afs*50.36
UCECchr163757291In_Frame_DelnovelS1229_N1232del0.18
UCECchr163736665Missense_MutationNAI1515M0.33
UCECchr163729764Frame_Shift_DelnovelS1761Rfs*90.52
UCECchr163781292Missense_MutationnovelN530D0.33
UCECchr163850390SilentnovelS235S0.4
UCECchr1637275583'UTRnovel0.52
UCECchr163727728Missense_MutationnovelE2440V0.13
UCECchr163769303SilentnovelS977S0.11
UCECchr1637251333'UTRnovel0.5
UCECchr163727837Missense_MutationnovelE2404K0.54
UCECchr163728114Silentrs149723395P2311P0.08
UCECchr163740496Missense_MutationnovelL1346M0.45
UCECchr163770590Missense_Mutationrs373284909A954T0.53
UCECchr163781224SilentnovelP552P0.54
UCECchr163728766Missense_MutationNAP2094L0.49
UCECchr163851007Missense_MutationnovelF30V0.06
UCECchr163767780Nonsense_MutationnovelE1064*0.08
UCECchr163850320Missense_MutationNAA259T0.14
UCECchr163728176Missense_MutationNAL2291M0.32
UCECchr1637267803'UTRnovel0.17
UCECchr163731830SilentnovelN1612N0.28
UCECchr163773849Missense_Mutationrs746728741A789T0.27
UCECchr163850536Missense_MutationnovelG187S0.32
UCECchr163850632Missense_MutationnovelA155S0.12
UCECchr163770818Missense_MutationnovelT878P0.4
UCECchr163850363Silentrs374065235T244T0.31
UCECchr163729074Silentrs539366777P1991P0.5
UCECchr163810780Splice_SitenovelX267_splice0.4
UCECchr163850417SilentnovelY226Y0.31
UCECchr163850937Missense_MutationnovelL53P0.37
UCECchr163793498Frame_Shift_InsNAR369Efs*580.32
UCECchr163727958Silentrs199610814P2363P0.28
UCECchr163731368Missense_MutationNAA1666T0.16
UCECchr163728437Nonsense_MutationnovelQ2204*0.48
UCECchr163728832Missense_MutationNAR2072Q0.29
UCECchr163729703Missense_MutationNAA1782T0.26
UCECchr163781268Missense_MutationNAT538P0.44
UCECchr163738636Missense_MutationNAF1439L0.41
UCECchr163728737Missense_MutationNAR2104C0.29
UCECchr163767775SilentnovelS1065S0.05
UCECchr163744920Missense_MutationNAR1319Q0.34
UCECchr163745308Missense_Mutationrs559939930V1295I0.45
UCECchr163773895Silentrs560358764P773P0.39
UCECchr163777631Missense_MutationnovelR714S0.41
UCECchr163780753Missense_MutationNAR601Q0.25
UCECchr163850355Missense_MutationnovelS247Y0.17
UCECchr163850748Missense_MutationnovelS116I0.17
UCECchr163728965Frame_Shift_DelnovelQ2028Sfs*120.4
UCECchr163767720Frame_Shift_DelNAI1084Sfs*150.19
UCECchr163728766Missense_MutationNAP2094L0.39
UCECchr163751768Missense_MutationNAG1246D0.23
UCECchr163773770Missense_MutationnovelA815V0.14
UCECchr163778767Missense_MutationNAR625H0.24
UCECchr1637267963'UTRnovel0.34
UCECchr163728647Missense_MutationnovelH2134Y0.44
UCECchr163729530Silentrs760307939P1839P0.42
UCECchr163781307Splice_SitenovelX525_splice0.33
UCECchr163792041Nonsense_Mutationrs587783464R424*0.11
UCECchr163728818Missense_MutationnovelP2077S0.08
UCECchr163729003Missense_MutationnovelS2015N0.27
UCECchr163729849Missense_MutationnovelY1733C0.26
UCECchr163773849Missense_Mutationrs746728741A789T0.35
UCECchr163780813Missense_MutationnovelA581D0.37
UCSchr163728745Missense_MutationnovelI2101T0.9
UCSchr163731413Missense_MutationnovelD1651N0.16
UCSchr163739683Missense_MutationNAR1392Q0.31
UCSchr163767822Nonsense_MutationNAE1050*0.39
UCSchr163850478Missense_Mutationrs759312345A206V0.36

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.53330.22898
BLCADEL0.34073.2014e-16
CHOLDEL0.11110.23475
LUSCDEL0.28944.5325e-06
OVDEL0.50431.7553e-08
UCECDEL0.15030.00027242

Survival Analysis
CancerP-value Q-value
SKCM0.0045

Kaplan-Meier Survival Analysis

ESCA0.05

Kaplan-Meier Survival Analysis

READ0.03

Kaplan-Meier Survival Analysis

THCA0.041

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000005339 (Gene tree)
Gene ID
1387
Gene Symbol
CREBBP
Alias
RTS|CBP|KAT3A|RSTS
Full Name
CREB binding protein
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
155,673 bases
Position
chr16:3,725,054-3,880,726
Accession
2348
RBP type
non-canonical RBP
Summary
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
18509338Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.Nature2008 Jul 3Wang Xdoi: 10.1038/nature06992
29511340LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein.Cell Death Differ2018 NovLiang Ydoi: 10.1038/s41418-018-0084-9
15764595Role of cyclophilin B in activation of interferon regulatory factor-3.J Biol Chem2005 May 6Obata Y-
22113303Promoter-associated noncoding RNA from the CCND1 promoter.Methods Mol Biol2012Song Xdoi: 10.1007/978-1-61779-376-9_39.
30572639CBP/β-Catenin/FOXM1 Is a Novel Therapeutic Target in Triple Negative Breast Cancer.Cancers (Basel)2018 Dec 19Ring Adoi: 10.3390/cancers10120525.
28891741eRNA binding produces tailored CBP activity profiles to regulate gene expression.RNA Biol2017 Dec 2Bose DAdoi: 10.1080/15476286.2017.1353862
9560216Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.Proc Natl Acad Sci U S A1998 Apr 28LaMorte VJ-
11912212Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation.J Biol Chem2002 May 31Misra P-
28680062Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.Sci Rep2017 Jul 5Contreras-Martos Sdoi: 10.1038/s41598-017-04611-x.
27528402Human satellite-III non-coding RNAs modulate heat-shock-induced transcriptional repression.J Cell Sci2016 Oct 1Goenka A-
16935882DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.Nucleic Acids Res2006Fuller-Pace FV-
29784880Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity.J Biol Chem2018 Jul 13Cui Wdoi: 10.1074/jbc.RA117.000598
16525063Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.J Neurosci2006 Mar 8Bates EA-
10839822Acetylation of histones and transcription-related factors.Microbiol Mol Biol Rev2000 JunSterner DE-
19476549Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1.J Neurochem2009 JunTian Fdoi: 10.1111/j.1471-4159.2009.06058.x
22564436Mechanism of PKA-dependent and lipid-raft independent stimulation of Connexin43 expression by oxytoxin in mouse embryonic stem cells.Mol Endocrinol2012 JulYun SPdoi: 10.1210/me.2011-1343
24603712β-agonists selectively modulate proinflammatory gene expression in skeletal muscle cells via non-canonical nuclear crosstalk mechanisms.PLoS One2014 Mar 6Kolmus Kdoi: 10.1371/journal.pone.0090649
24014683Activation of developmental nuclear fibroblast growth factor receptor 1 signaling and neurogenesis in adult brain by α7 nicotinic receptor agonist.Stem Cells Transl Med2013 OctNarla STdoi: 10.5966/sctm.2012-0103
9488451Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1.Mol Cell Biol1998 MarWeaver BK-
12438313Opposite regulation of myc and p21waf1 transcription by STAT3 proteins.J Biol Chem2003 Jan 31Barre B-
12459554Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription.J Biol Chem2003 Feb 14Araya N-
12163469Nuclear DNA helicase II is recruited to IFN-alpha-activated transcription sites at PML nuclear bodies.J Cell Biol2002 Aug 5Fuchsova B-
12052862Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter.Mol Cell Biol2002 JulBenkoussa M-
12070172Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase II with the phosphoenolpyruvate carboxykinase gene promoter.J Biol Chem2002 Aug 30Duong DT-
10893273CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus.J Cell Biol2000 Jul 10von Mikecz A-
15677471The STAT3 transcription factor is a target for the Myc and riboblastoma proteins on the Cdc25A promoter.J Biol Chem2005 Apr 22Barre B-
15560845Human T lymphotropic virus type-1 p30II alters cellular gene expression to selectively enhance signaling pathways that activate T lymphocytes.Retrovirology2004 Nov 23Michael B-
15464984Functional interaction between Smad, CREB binding protein, and p68 RNA helicase.Biochem Biophys Res Commun2004 Nov 5Warner DR-
15355351RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator.Eur J Biochem2004 SepTetsuka T-
14612417The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription.Mol Cell Biol2003 DecHsu LC-
19406844cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP.FASEB J2009 SepBurke SJdoi: 10.1096/fj.08-126631
19122173Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells.Arterioscler Thromb Vasc Biol2009 MarDje N'Guessan Pdoi: 10.1161/ATVBAHA.108.178319
17947670Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia.J Immunol2007 Nov 1Qin H-
17634129Human T-lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survival.Retrovirology2007 Jul 16Datta A-
17317667The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication.J Biol Chem2007 Apr 20Sharma A-
17296604Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.J Biol Chem2007 May 18Johnson J-
17114447IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3.J Immunol2006 Dec 1Qin H-
22787137Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1α with CREB-binding protein.Diabetes2012 OctGautier-Stein A-
20833730TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-kB, and the transcriptional coactivator CREB-binding protein.J Biol Chem2010 Sep 17Clarke DLdoi: 10.1074/jbc.M109.0999952.
24253305Molecular recognition by the KIX domain and its role in gene regulation.Nucleic Acids Res2014 FebThakur JKdoi: 10.1093/nar/gkt1147
24204704Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes.PLoS One2013 Oct 18Garrigan Edoi: 10.1371/journal.pone.0076919
29217191TNF-α induces expression of the circadian clock gene Bmal1 via dual calcium-dependent pathways in rheumatoid synovial cells.Biochem Biophys Res Commun2018 Jan 8Yoshida Kdoi: 10.1016/j.bbrc.2017.12.015
30157918SP1-induced lncRNA AGAP2-AS1 expression promotes chemoresistance of breast cancer by epigenetic regulation of MyD88.J Exp Clin Cancer Res2018 Aug 29Dong Hdoi: 10.1186/s13046-018-0875-3.
9794790P/CAF/p300 complex binds the promoter for the heavy subunit of ferritin and contributes to its tissue-specific expression.Biochem J1998 Nov 1Bevilacqua MA-
9087428Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors.Genes Dev1997 Mar 15Nakajima T-
12851713Aromatic residues are required for RNA helicase A mediated transactivation.Int J Mol Med2003 AugAratani S-
11416126Dual roles of RNA helicase A in CREB-dependent transcription.Mol Cell Biol2001 JulAratani S-
15615775Role of CBP in regulating HIF-1-mediated activation of transcription.J Cell Sci2005 Jan 15Ruas JL-
15375574The influence of neural signal transduction on EEC gene expression under consideration of chromatin, following myenteric ablation (review).Int J Mol Med2004 OctHolle GE-
15331701VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection.J Virol2004 SepHerrera FJ-
15313412CBP and p300: HATs for different occasions.Biochem Pharmacol2004 Sep 15Kalkhoven E-
15021911The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity.Oncogene2004 May 6Babic I-
22954786p300/CBP acetyl transferases interact with and acetylate the nucleotide excision repair factor XPG.DNA Repair (Amst)2012 Oct 1Tillhon Mdoi: 10.1016/j.dnarep.2012.08.001
22493065Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27.Mol Cell Biol2012 JunTie Fdoi: 10.1128/MCB.06392-11
23358192Identification of transcription factors and coactivators affected by dibutylphthalate interactions in fetal rat testes.Toxicol Sci2013 AprPlummer SMdoi: 10.1093/toxsci/kft016
22113271Two-step cross-linking for analysis of protein-chromatin interactions.Methods Mol Biol2012Tian Bdoi: 10.1007/978-1-61779-376-9_7.
21191649P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis.Breast Cancer Res Treat2011 NovFuchs-Young Rdoi: 10.1007/s10549-010-1308-y
26710457[Acetylated Histone Expressions of the Primary Hippocampal Neurons in Rats Reduced by siCBP Lentivirus].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi2015 AugHou N-
28398509MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.Nucleic Acids Res2017 Jun 20Lai Bdoi: 10.1093/nar/gkx234.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000575237CREBBP-211403--- (aa)--
ENST00000576720CREBBP-2123578--- (aa)--
ENST00000636895CREBBP-218100--- (aa)--
ENST00000637492CREBBP-219100-ENSP0000049024433 (aa)-A0A1B0GUU0
ENST00000635899CREBBP-215100--- (aa)--
ENST00000636002CREBBP-21784--- (aa)--
ENST00000571763CREBBP-204548--- (aa)--
ENST00000573672CREBBP-209922--- (aa)--
ENST00000382070CREBBP-2027598-ENSP000003715022404 (aa)-Q92793
ENST00000573517CREBBP-208718-ENSP00000460474196 (aa)-I3L3I5
ENST00000574740CREBBP-210523--- (aa)--
ENST00000634839CREBBP-213339--- (aa)--
ENST00000635753CREBBP-214100--- (aa)--
ENST00000572569CREBBP-207553--- (aa)--
ENST00000571826CREBBP-205627-ENSP00000459490181 (aa)-I3L293
ENST00000570939CREBBP-2033316-ENSP000004610021105 (aa)-I3L466
ENST00000638158CREBBP-22097--- (aa)--
ENST00000635919CREBBP-216100--- (aa)--
ENST00000572134CREBBP-206846-ENSP00000458254254 (aa)-I3L0Q1
ENST00000262367CREBBP-20110803XM_005255124ENSP000002623672442 (aa)XP_005255181Q92793
Gene Model
Click here to download ENSG00000005339's gene model file
Pathways
Pathway IDPathway NameSource
hsa04024cAMP signaling pathwayKEGG
hsa04066HIF-1 signaling pathwayKEGG
hsa04068FoxO signaling pathwayKEGG
hsa04110Cell cycleKEGG
hsa04310Wnt signaling pathwayKEGG
hsa04330Notch signaling pathwayKEGG
hsa04350TGF-beta signaling pathwayKEGG
hsa04520Adherens junctionKEGG
hsa04630JAK-STAT signaling pathwayKEGG
hsa04720Long-term potentiationKEGG
hsa04916MelanogenesisKEGG
hsa04919Thyroid hormone signaling pathwayKEGG
hsa04922Glucagon signaling pathwayKEGG
hsa05016Huntington diseaseKEGG
hsa05152TuberculosisKEGG
hsa05161Hepatitis BKEGG
hsa05164Influenza AKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05166Human T-cell leukemia virus 1 infectionKEGG
hsa05167Kaposi sarcoma-associated herpesvirus infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05203Viral carcinogenesisKEGG
hsa05206MicroRNAs in cancerKEGG
hsa05211Renal cell carcinomaKEGG
hsa05215Prostate cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000005339Body Weights and Measures2.45314842894787E-617903300
ENSG00000005339Body Weights and Measures2.66366128675991E-617903300
ENSG00000005339Electrocardiography9E-623459443
ENSG00000005339Insulin-Like Growth Factor Binding Protein 39E-623251661
ENSG00000005339Neurofibrillary Tangles4E-625188341
ENSG00000005339Cleft Lip9E-1225775280
ENSG00000005339Cleft Palate9E-1225775280
ENSG00000005339Electrocardiography4E-1024952745
ENSG00000005339Cleft Lip1E-1028232668
ENSG00000005339Cleft Palate1E-1028232668
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000005339rs1296720163823641CQT interval24952745[0.58-1.08] unit increase0.83EFO_0004682
ENSG00000005339rs129963163746146TQT interval (drug interaction)23459443EFO_0007981|EFO_0004682
ENSG00000005339rs3751845163728336AObesity-related traits23251661[NR] ng/mL increase0.03EFO_0004626
ENSG00000005339rs17199009163817080GAge of smoking initiation (MTAG)30643251[0.0099-0.0217] unit increase0.0158124EFO_0005670
ENSG00000005339rs130017163741392?Heel bone mineral density30595370EFO_0009270
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000005339's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II21539536.IDAProcess
GO:0000123histone acetyltransferase complex-IEAComponent
GO:0000790nuclear chromatin21539536.IDAComponent
GO:0000987proximal promoter sequence-specific DNA binding21539536.IDAFunction
GO:0001085RNA polymerase II transcription factor binding21539536.IPIFunction
GO:0001102RNA polymerase II activating transcription factor binding11001584.TASFunction
GO:0001666response to hypoxia15261140.TASProcess
GO:0002039p53 binding9194565.IPIFunction
GO:0002223stimulatory C-type lectin receptor signaling pathway-TASProcess
GO:0003682chromatin binding24939902.IDAFunction
GO:0003684damaged DNA binding24939902.IDAFunction
GO:0003713transcription coactivator activity12169688.12435739.12586840.12929931.14645221.IDAFunction
GO:0003713transcription coactivator activity8684459.IPIFunction
GO:0003713transcription coactivator activity10362258.11001584.TASFunction
GO:0003714transcription corepressor activity21539536.IDAFunction
GO:0004402histone acetyltransferase activity11742995.IDAFunction
GO:0004402histone acetyltransferase activity10362258.TASFunction
GO:0005515protein binding8684459.9018065.9194564.9323138.9687513.9811832.9887100.10049825.10196247.10347196.10428834.10722728.10722738.10823891.10866662.11568182.11799127.11897665.11940655.11971985.12435739.12482968.14645221.14716005.15075319.15126506.15220471.15273251.15674325.16043483.16154084.16291753.16611888.16799563.17075044.17362989.17382325.17476304.17500595.17923090.18309294.18316612.18836453.19234109.19805293.20541699.20541704.20581830.21602890.21670263.21751375.21903422.23273993.23434580.23441852.23746807.24361270.24939902.25241761.25314079.25609649.IPIFunction
GO:0005634nucleus12169688.ICComponent
GO:0005634nucleus12929931.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm12929931.IDAComponent
GO:0006355regulation of transcription, DNA-templated12169688.IDAProcess
GO:0006355regulation of transcription, DNA-templated15261140.TASProcess
GO:0006367transcription initiation from RNA polymerase II promoter-TASProcess
GO:0006473protein acetylation15273251.24939902.IDAProcess
GO:0006473protein acetylation28386764.TASProcess
GO:0007165signal transduction15261140.NASProcess
GO:0007219Notch signaling pathway-TASProcess
GO:0007221positive regulation of transcription of Notch receptor target-TASProcess
GO:0008134transcription factor binding15509593.IPIFunction
GO:0008270zinc ion binding-IEAFunction
GO:0008589regulation of smoothened signaling pathway11001584.TASProcess
GO:0016032viral process-IEAProcess
GO:0016407acetyltransferase activity12456660.16135789.EXPFunction
GO:0016407acetyltransferase activity11742995.15273251.24939902.IDAFunction
GO:0016573histone acetylation11742995.IDAProcess
GO:0016604nuclear body15488321.IDAComponent
GO:0018076N-terminal peptidyl-lysine acetylation12435739.IDAProcess
GO:0019216regulation of lipid metabolic process-TASProcess
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathway25514493.IMPProcess
GO:0031648protein destabilization24939902.IMPProcess
GO:0032481positive regulation of type I interferon production-TASProcess
GO:0034644cellular response to UV24939902.IDAProcess
GO:0042592homeostatic process15261140.NASProcess
GO:0042733embryonic digit morphogenesis11001584.TASProcess
GO:0042981regulation of apoptotic process-TASProcess
GO:0043426MRF binding8621548.IDAFunction
GO:0045637regulation of myeloid cell differentiation-TASProcess
GO:0045747positive regulation of Notch signaling pathway-TASProcess
GO:0045893positive regulation of transcription, DNA-templated11742995.IDAProcess
GO:0045893positive regulation of transcription, DNA-templated-ISSProcess
GO:0045944positive regulation of transcription by RNA polymerase II-TASProcess
GO:0048511rhythmic process-IEAProcess
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia-TASProcess
GO:0065003protein-containing complex assembly7913207.TASProcess
GO:1900034regulation of cellular response to heat-TASProcess
GO:1904837beta-catenin-TCF complex assembly-TASProcess
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