EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24342434γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors.Hum Pathol2014 FebTakemura Kdoi: 10.1016/j.humpath.2013.09.009
25941902γ-Glutamylcyclotransferase Knockdown Inhibits Growth of Lung Cancer Cells Through G0/G1 Phase Arrest.Cancer Biother Radiopharm2015 JunLin Zdoi: 10.1089/cbr.2014.1807
26828272Gamma-glutamylcyclotransferase promotes the growth of human glioma cells by activating Notch-Akt signaling.Biochem Biophys Res Commun2016 Mar 18Shen SHdoi: 10.1016/j.bbrc.2016.01.165
29307834Prohibitin-2 is a novel regulator of p21WAF1/CIP1 induced by depletion of γ-glutamylcyclotransferase.Biochem Biophys Res Commun2018 Jan 29Taniguchi Kdoi: 10.1016/j.bbrc.2018.01.029

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr730498883Missense_MutationNAQ115E0.06
BLCAchr730497119Silentrs201709515I180I0.17
BLCAchr730498836Silentrs753110206Y130Y0.1
BLCAchr7305047225'UTRnovel0.19
BRCAchr730504617SilentnovelI31I0.2
BRCAchr730504643Missense_MutationnovelG23C0.29
BRCAchr7304969183'UTRnovel0.09
BRCAchr730497139Missense_MutationnovelE174K0.06
COADchr730497185Missense_MutationNAE158D0.33
COADchr730498888Missense_MutationNAA113E0.33
COADchr730498823Missense_MutationNAP135T0.28
ESCAchr730500544SilentnovelS93S0.36
GBMchr7305047485'UTRnovel0.26
GBMchr730504619Missense_MutationnovelI31V0.25
GBMchr730498819Missense_MutationnovelS136Y0.08
HNSCchr730498892Missense_MutationNAV112L0.07
KIRCchr730498918Missense_MutationNAG103E0.33
LGGchr730498836Silentrs753110206Y130Y0.41
LUADchr730498859Nonsense_Mutationrs758508499R123*0.06
LUADchr7305047355'UTRnovel0.28
LUSCchr730504596SilentNAA38A0.35
LUSCchr730498876Missense_MutationnovelG117V0.26
LUSCchr730498877Missense_MutationnovelG117R0.25
LUSCchr7304969783'UTRnovel0.27
LUSCchr730498918Missense_MutationNAG103A0.46
LUSCchr7305048245'UTRnovel0.12
OVchr730500594Missense_Mutationrs766416927D77N0.35
PRADchr730498835Missense_Mutationrs765582824E131K0.18
READchr730500545Missense_Mutationrs776460145S93Y0.33
SKCMchr730498826Missense_Mutationrs142543540P134S0.19
SKCMchr7304969973'UTRnovel0.5
STADchr730504699Nonsense_MutationNAS4*0.24
THCAchr730498901Missense_MutationnovelE109Q0.14
UCECchr730498858Missense_Mutationrs371796444R123Q0.16
UCECchr730500612Missense_MutationnovelI71V0.07
UCECchr7304970423'UTRnovel0.08
UCECchr730498894Missense_MutationnovelK111R0.51
UCECchr7304969313'UTRnovel0.23
UCECchr730500599Missense_MutationNAP75H0.49
UCECchr7304970053'UTRnovel0.36
UCECchr7304969053'UTRnovel0.15
UCECchr730500681Missense_MutationnovelD48N0.14
UCECchr7305048115'UTRnovel0.25
UCECchr7304970473'UTRnovel0.56
UCECchr730500661SilentNAG54G0.45
UCECchr730498858Missense_Mutationrs371796444R123Q0.33
UCECchr730497169Nonsense_MutationnovelE164*0.28
UCECchr730500545Missense_Mutationrs776460145S93Y0.26
UCECchr730500594Missense_Mutationrs766416927D77N0.37
UCECchr730500570Missense_MutationnovelK85E0.12
UCECchr730497232Missense_MutationnovelI143F0.52
UCECchr7304970473'UTRnovel0.04
UCECchr730497169Nonsense_MutationnovelE164*0.06
UCECchr730497167SilentnovelE164E0.43

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
PRADAMP0.14840.02772
THCADEL00.27619

Survival Analysis
CancerP-value Q-value
KIRC0.0001

Kaplan-Meier Survival Analysis

ACC0.00062

Kaplan-Meier Survival Analysis

HNSC0.019

Kaplan-Meier Survival Analysis

LUSC0.0034

Kaplan-Meier Survival Analysis

BRCA0.0025

Kaplan-Meier Survival Analysis

ESCA0.016

Kaplan-Meier Survival Analysis

TGCT0.015

Kaplan-Meier Survival Analysis

KIRP0.034

Kaplan-Meier Survival Analysis

PAAD0.0049

Kaplan-Meier Survival Analysis

KICH0.0018

Kaplan-Meier Survival Analysis

GBM0.00099

Kaplan-Meier Survival Analysis

LIHC0.004

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

CHOL0.049

Kaplan-Meier Survival Analysis

THCA0.002

Kaplan-Meier Survival Analysis

OV0.012

Kaplan-Meier Survival Analysis

Drugs

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Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000006625 (Gene tree)
Gene ID
79017
Gene Symbol
GGCT
Alias
MGC3077|CRF21|Ggc|C7orf24|GCTG
Full Name
gamma-glutamylcyclotransferase
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
8,224 bases
Position
chr7:30,496,621-30,504,844
Accession
21705
RBP type
non-canonical RBP
Summary
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000275428GGCT-2021173-ENSP00000275428188 (aa)-O75223
ENST00000409144GGCT-203836-ENSP0000038661094 (aa)-O75223
ENST00000426081GGCT-206889-ENSP00000390094119 (aa)-H7BZK5
ENST00000005374GGCT-2011032-ENSP00000005374114 (aa)-O75223
ENST00000440082GGCT-2071012-ENSP0000040801551 (aa)-A0A0B4J1Y4
ENST00000409436GGCT-205954-ENSP00000386686166 (aa)-B8ZZK2
ENST00000447901GGCT-208784-ENSP0000038780951 (aa)-A0A0B4J1Y4
ENST00000409390GGCT-204767-ENSP00000387235166 (aa)-O75223
Gene Model
Click here to download ENSG00000006625's gene model file
Pathways
Pathway IDPathway NameSource
hsa00480Glutathione metabolismKEGG
hsa01100Metabolic pathwaysKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000006625's network
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001836release of cytochrome c from mitochondria16765912.IMPProcess
GO:0003839gamma-glutamylcyclotransferase activity18515354.IDAFunction
GO:0005829cytosol16765912.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006750glutathione biosynthetic process-TASProcess
GO:0042803protein homodimerization activity17932939.18515354.IDAFunction
GO:0070062extracellular exosome19056867.HDAComponent
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