EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19012002Expression profile of BRCA1 and BRCA2 genes in premenopausal Mexican women with breast cancer: clinical and immunohistochemical correlates.Med Oncol2009Loredo-Pozos Gdoi: 10.1007/s12032-008-9114-7
28900739A frameshift mutation in BRCA1 leads to hereditary breast and ovarian cancer in one part of a family and to familial pancreatic cancer in another.Breast Cancer Res Treat2018 JanGieldon Ldoi: 10.1007/s10549-017-4500-5
26392358Methylation biomarkers for pleomorphic lobular breast cancer - a short report.Cell Oncol (Dordr)2015 OctMoelans CBdoi: 10.1007/s13402-015-0241-9
24915755A germline mutation in the BRCA1 3'UTR predicts Stage IV breast cancer.BMC Cancer2014 Jun 10Dorairaj JJdoi: 10.1186/1471-2407-14-421.
21781528[The correlation between chemotherapeutic efficacy and breast cancer susceptibility gene 1 and class IIIβ-tubulin protein expression in non-small cell lung cancer patients].Zhonghua Nei Ke Za Zhi2011 JunWan YYdoi: 10.3760/cma.j.issn.0578-142.2011.06.006.
24335192EZH2 participates in malignant biological behavior of epithelial ovarian cancer through regulating the expression of BRCA1.Cancer Biol Ther2014 Mar 1Li Tdoi: 10.4161/cbt.27306
25319390miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.Mol Cancer Ther2014 DecTang Hdoi: 10.1158/1535-7163.MCT-14-0243
25132263BRCA1-IRIS inactivation sensitizes ovarian tumors to cisplatin.Oncogene2015 Jun 4Paul BTdoi: 10.1038/onc.2014.237
16543155A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination.Mol Cell2006 Mar 17Brzovic PS-
25480944TUSC4 functions as a tumor suppressor by regulating BRCA1 stability.Cancer Res2015 Jan 15Peng Ydoi: 10.1158/0008-5472.CAN-14-2315
22579790Outcomes of primary surgical cytoreduction in patients with BRCA-associated high-grade serous ovarian carcinoma.Gynecol Oncol2012 AugHyman DMdoi: 10.1016/j.ygyno.2012.05.001
14576434Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2.Science2003 Oct 24King MC-
23047605Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production.Cell Cycle2012 Nov 15Salem AFdoi: 10.4161/cc.22316
12607598Frequent loss of BRCA1 nuclear expression in young women with breast cancer: an immunohistochemical study from an area of low incidence but early onset.Appl Immunohistochem Mol Morphol2002 DecLee WY-
18445692Loss of heterozygosity at the BRCA2 locus detected by multiplex ligation-dependent probe amplification is common in prostate cancers from men with a germline BRCA2 mutation.Clin Cancer Res2008 May 15Willems AJdoi: 10.1158/1078-0432.CCR-07-5237
22931600[BRCA1 inhibits progesterone-induced proliferation and migration of breast cancer cells].Nan Fang Yi Ke Da Xue Xue Bao2012 AugXiong J-
16011248[Genetic instability on chromosome 17q21 in gastric cancer of Chinese patients].Shi Yan Sheng Wu Xue Bao2005 AprLin XQ-
25522926Tumor-associated inflammation as a potential prognostic tool in BRCA1/2-associated breast cancer.Hum Pathol2015 Febvan Verschuer VMdoi: 10.1016/j.humpath.2014.10.020
24935384No association between BRCA1 immunohistochemical expression and tumor grade, stage or overall survival in platinum-treated epithelial ovarian cancer patients.Asian Pac J Cancer Prev2014Shawky Ael-A-
16945238Medullary carcinoma of breast with a novel germline mutation 1123T >G in exon 11 of BRCA1.J Coll Physicians Surg Pak2006 SepMoattar T-
18045956Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations.Endocr Relat Cancer2007 DecHudelist G-
27008870Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms.Hum Mol Genet2016 Jun 1de la Hoya M-
28358361Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines.Cell Death Dis2017 Mar 30Karanam NKdoi: 10.1038/cddis.2017.136.
29712865Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1.Proc Natl Acad Sci U S A2018 May 15Seo Adoi: 10.1073/pnas.1801796115
29970689Extent of breast cancer type 1 promoter methylation correlates with clinicopathological features in breast cancers.J Cancer Res Ther2018 JunSun MYdoi: 10.4103/0973-1482.235354.
30733286AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.Proc Natl Acad Sci U S A2019 Feb 26Kubli SPdoi: 10.1073/pnas.1815126116
26048987Deciphering the BRCA1 Tumor Suppressor Network.J Biol Chem2015 Jul 17Jiang Qdoi: 10.1074/jbc.R115.667931
20389018HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.J Clin Invest2010 MayGilbert PMdoi: 10.1172/JCI39534
25496700Plasma mRNA expression levels of BRCA1 and TS as potential predictive biomarkers for chemotherapy in gastric cancer.J Transl Med2014 Dec 14Shen Jdoi: 10.1186/s12967-014-0355-2.
28376175Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers.J Natl Cancer Inst2017 Jul 1Kuchenbaecker KBdoi: 10.1093/jnci/djw302.
20845286Induction of breast cancer in wild type p53 cells by BRCA1-IRIS overexpression.Hawaii Med J2010 AugElshamy WM-
27249681Women's Health Issues for BRCA Mutation Carriers.Am Soc Clin Oncol Educ Book2016Sabatini MEdoi: 10.14694/EDBK_100001.
28364669Suggestion of BRCA1 c.5339T>C (p.L1780P) variant confer from 'unknown significance' to 'Likely pathogenic' based on clinical evidence in Korea.Breast2017 JunRyu JMdoi: 10.1016/j.breast.2017.03.006
16772120Gross rearrangements in BRCA1 but not BRCA2 play a notable role in predisposition to breast and ovarian cancer in high-risk families of German origin.Cancer Genet Cytogenet2006 Jul 1Preisler-Adams S-
26588056Risk-reducing surgery in BRCA 1/2 mutation carries: a point of view.Oncotarget2015 Nov 24De Felice Fdoi: 10.18632/oncotarget.6348.
26989051Male breast cancer is not congruent with the female disease.Crit Rev Oncol Hematol2016 MayFentiman ISdoi: 10.1016/j.critrevonc.2016.02.017
26414677Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.Nat Genet2015 NovDay FRdoi: 10.1038/ng.3412
12096901Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.J Mol Biol2002 Jul 12Ekblad CM-
12509456Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.Mol Cell Biol2003 JanMiralem T-
26715507Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis.BMC Cancer2015 Dec 29Romagnolo DFdoi: 10.1186/s12885-015-2044-9.
27003155NGS-based BRCA1/2 mutation testing of high-grade serous ovarian cancer tissue: results and conclusions of the first international round robin trial.Virchows Arch2016 JunEndris Vdoi: 10.1007/s00428-016-1919-8
20032382Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer.Anticancer Res2009 NovSchjlberg AR-
19120025Cloning and functional identification of two novel BRCA1 splicing variants.Biochemistry (Mosc)2008 NovMiao L-
21946536Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.Nat Med2011 Sep 25Chang Sdoi: 10.1038/nm.2459.
17307836Cancer risks in carriers of the BRCA1/2 Ashkenazi founder mutations.J Med Genet2007 JulKadouri L-
24168967miR-9 regulation of BRCA1 and ovarian cancer sensitivity to cisplatin and PARP inhibition.J Natl Cancer Inst2013 Nov 20Sun Cdoi: 10.1093/jnci/djt302
23155271Prognostic significance of ERCC1, RRM1 and BRCA1 in surgically-treated patients with non-small cell lung cancer.Anticancer Res2012 NovPesta M-
26745875BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing.Oncotarget2016 Jan 12Mafficini Adoi: 10.18632/oncotarget.6834.
16843262Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature.Cancer Cell2006 JulFuruta S-
17505536Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia.Int J Biol Sci2007 Apr 25Hoshino A-
16326698BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.J Biol Chem2006 Feb 10Moreau K-
20581465BRCA1 regulation of base excision repair pathway.Cell Cycle2010 Jul 1Saha Tdoi: 10.4161/cc.9.13.12084.
24675954Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.Science2014 Mar 28Venkitaraman ARdoi: 10.1126/science.1252230.
22382806Prevalence of BRCA1 and BRCA2 mutations in non-familial breast cancer patients with high risks in Korea: the Korean Hereditary Breast Cancer (KOHBRA) Study.Breast Cancer Res Treat2012 JunSon BHdoi: 10.1007/s10549-012-2001-0
16782705BRCA1 interacts with poly(A)-binding protein: implication of BRCA1 in translation regulation.J Biol Chem2006 Aug 25Dizin E-
15665273Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.Cancer Res2005 Jan 1Hayami R-
17000754Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions.Mol Cell Biol2006 DecBartz SR-
26227317Association of HO-1 and BRCA1 Is Critical for the Maintenance of Cellular Homeostasis in Prostate Cancer.Mol Cancer Res2015 NovLabanca Edoi: 10.1158/1541-7786.MCR-15-0150-T
22392482Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-γ.Apoptosis2012 JulWarrener Pdoi: 10.1007/s10495-012-0707-4.
25216750ABCG2, a novel antigen to sort luminal progenitors of BRCA1- breast cancer cells.Mol Cancer2014 Sep 12Leccia Fdoi: 10.1186/1476-4598-13-213.
17921118Immunolocalization of BRCA1 protein in tumor breast tissue: prescreening of BRCA1 mutation in Tunisian patients with hereditary breast cancer?Eur J Histochem2007 Jul-SepTroudi W-
20890790[Genes beyond BRCA1 and BRCA2 for hereditary breast cancer].Wien Med Wochenschr2010 NovSimon Kdoi: 10.1007/s10354-010-0831-0.
12086871The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients.Cancer Cell2002 MarElledge SJ-
25884417BRCA1 Alternative splicing landscape in breast tissue samples.BMC Cancer2015 Apr 3Romero Adoi: 10.1186/s12885-015-1145-9.
16969499Missense mutations of BRCA1 gene affect the binding with p53 both in vitro and in vivo.Oncol Rep2006 OctQuaresima B-
23567481Breast cancer size estimation with MRI in BRCA mutation carriers and other high risk patients.Eur J Radiol2013 SepMann RMdoi: 10.1016/j.ejrad.2013.03.003
22172724BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.Cancer Cell2011 Dec 13Drost Rdoi: 10.1016/j.ccr.2011.11.014.
21729660Development of breast cancer in a 21-year-old childhood Wilms' tumor survivor with a BRCA1 2634delC mutation.Clin Breast Cancer2011 AugDulude AMdoi: 10.1016/j.clbc.2010.11.001
23674270BRCA1 polymorphisms and breast cancer epidemiology in the Western New York exposures and breast cancer (WEB) study.Genet Epidemiol2013 JulRicks-Santi LJdoi: 10.1002/gepi.21730
23047606Hereditary ovarian cancer and two-compartment tumor metabolism: epithelial loss of BRCA1 induces hydrogen peroxide production, driving oxidative stress and NF??B activation in the tumor stroma.Cell Cycle2012 Nov 15Martinez-Outschoorn UEdoi: 10.4161/cc.22226
15009718Downregulation of BRCA1 in A375 melanoma cell line increases radio-sensitivity and modifies metastatic and angiogenic gene expression.J Invest Dermatol2004 FebHesling C-
18683754[Influence of mifepristone on DNA repair genes and cisplatin sensitivity in human ovarian cancer drug-resistance cells].Zhonghua Fu Chan Ke Za Zhi2008 FebLiu GY-
16940470Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells.Am J Physiol Endocrinol Metab2007 JanGhosh S-
21344391Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins.J Cell Physiol2011 DecQin Ydoi: 10.1002/jcp.22695.
25460500Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells.Oncotarget2014 Dec 15Pickholtz I-
23860775MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency.Tumour Biol2013 DecRen Jdoi: 10.1007/s13277-013-0983-9
20103620Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination.Cancer Res2010 Feb 1Ransburgh DJdoi: 10.1158/0008-5472.CAN-09-2850
18703154Interaction of p14ARF with Brca1 in cancer cell lines and primary breast cancer.Cell Biol Int2008 OctHe Ldoi: 10.1016/j.cellbi.2008.07.018
21099359BRCA1 modulates the expression of hnRNPA2B1 and KHSRP.Cell Cycle2010 Dec 1Santarosa M-
22401979Allelic transcripts dosage effect in morphologically normal ovarian cells from heterozygous carriers of a BRCA1/2 French Canadian founder mutation.Cancer Prev Res (Phila)2012 MayAbd-Rabbo Ddoi: 10.1158/1940-6207.CAPR-11-0547
21194536Evolutionary dynamics of BRCA1 alterations in breast tumorigenesis.J Theor Biol2011 Mar 21De Vargas Roditi Ldoi: 10.1016/j.jtbi.2010.12.033
15220350Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.J Biol Chem2004 Aug 13Xu X-
21670155Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter.Mol Cell Biol2011 AugLu Ydoi: 10.1128/MCB.01121-10
15166217Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression.J Biol Chem2004 Aug 6Choudhury AD-
25879355Expression of BRCA1 and BRCA2 proteins and their correlation with clinical staging in breast cancer.J Cancer Res Ther2015 Jan-MarHedau Sdoi: 10.4103/0973-1482.140985.
21203981The role of BRCA1 in DNA damage response.Protein Cell2010 FebWu Jdoi: 10.1007/s13238-010-0010-5.
20398395Lympho-vascular invasion in BRCA related breast cancer compared to sporadic controls.BMC Cancer2010 Apr 16Heerma van Voss MRdoi: 10.1186/1471-2407-10-145.
19649554Breast-conserving surgery in BRCA1/2 mutation carriers: are we approaching an answer?Ann Surg Oncol2009 DecGarcia-Etienne CAdoi: 10.1245/s10434-009-0638-7.
17452776655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations.Cell Oncol2007Tommasi S-
26867710BRCA1 and BRCA2 Mutation Testing in Young Women With Breast Cancer.JAMA Oncol2016 Jun 1Rosenberg SMdoi: 10.1001/jamaoncol.2015.5941.
17496925A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation.Oncogene2007 Nov 8Li W-
20814958Insights into the targeted elimination of BRCA1-defective cancer stem cells.Med Res Rev2012 SepSomasundaram Vdoi: 10.1002/med.20229
24151232BRCA1-mediated inflammation and growth activated & inhibited transition mechanisms between no-tumor hepatitis/cirrhotic tissues and HCC.J Cell Biochem2014 AprDiao Hdoi: 10.1002/jcb.24699.
11983207Expression of BRCA1 and BRCA2 in different tumor cell lines with various growth status.Clin Chim Acta2002 JunVissac C-
20345474The contribution of founder mutations in BRCA1 to breast and ovarian cancer in Lithuania.Clin Genet2010 OctElsakov Pdoi: 10.1111/j.1399-0004.2010.01404.x.
25428789Inherited predisposition to breast cancer among African American women.Breast Cancer Res Treat2015 JanChurpek JEdoi: 10.1007/s10549-014-3195-0
22511931BRCA1-IRIS overexpression promotes formation of aggressive breast cancers.PLoS One2012Shimizu Ydoi: 10.1371/journal.pone.0034102
22843497Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer.Hum Mol Genet2012 Nov 1Hansmann Tdoi: 10.1093/hmg/dds308
27997688Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action.Int J Cancer2017 Apr 1Smith LDdoi: 10.1002/ijc.30574
26615718Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice.Radiother Oncol2016 MayBakr Adoi: 10.1016/j.radonc.2015.11.001
27193872Knockdown of COUP-TFII inhibits cell proliferation and induces apoptosis through upregulating BRCA1 in renal cell carcinoma cells.Int J Cancer2016 Oct 1Zheng Jdoi: 10.1002/ijc.30193
28377179Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers.Cancer Lett2017 Jul 1Sokolenko APdoi: 10.1016/j.canlet.2017.03.036
28549976BRCA mutational status, initial disease presentation, and clinical outcome in high-grade serous advanced ovarian cancer: a multicenter study.Am J Obstet Gynecol2017 SepPetrillo Mdoi: 10.1016/j.ajog.2017.05.036
28264838Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.Cancer Prev Res (Phila)2017 AprChiyoda Tdoi: 10.1158/1940-6207.CAPR-16-0281
27167707Detection of somatic BRCA1/2 mutations in ovarian cancer - next-generation sequencing analysis of 100 cases.Cancer Med2016 JulKoczkowska Mdoi: 10.1002/cam4.748
28857155Prevalent somatic BRCA1 mutations shape clinically relevant genomic patterns of nasopharyngeal carcinoma in Southeast Europe.Int J Cancer2018 Jan 1Fountzilas Gdoi: 10.1002/ijc.31023
28343309Breast cancer detection and tumor characteristics in BRCA1 and BRCA2 mutation carriers.Breast Cancer Res Treat2017 JunKrammer Jdoi: 10.1007/s10549-017-4198-4
27793035Performance of multiplicom's BRCA MASTR Dx kit on the detection of BRCA1 and BRCA2 mutations in fresh frozen ovarian and breast tumor samples.Oncotarget2016 Dec 6Badoer Cdoi: 10.18632/oncotarget.12877.
28499366The role of BRCA1-IRIS in the development and progression of triple negative breast cancers in Egypt: possible link to disease early lesion.BMC Cancer2017 May 12Bogan Ddoi: 10.1186/s12885-017-3283-8.
29860064Expression analysis of the MCPH1/BRIT1 and BRCA1 tumor suppressor genes and telomerase splice variants in epithelial ovarian cancer.Gene2018 Sep 25Alsiary Rdoi: 10.1016/j.gene.2018.05.113
27845331BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.Nat Commun2016 Nov 15Rasmussen RDdoi: 10.1038/ncomms13398.
30049201Methylation Profiles of BRCA1, RASSF1A and GSTP1 in Vietnamese Women with Breast CancerAsian Pac J Cancer Prev2018 Jul 27Vu TL-
30315757Additional molecular and clinical evidence open the way to definitive IARC classification of the BRCA1 c.5332G>A (p.Asp1778Asn) variant.Clin Biochem2019 JanMinucci Adoi: 10.1016/j.clinbiochem.2018.10.004
28680148Prevalence and Penetrance of BRCA1 and BRCA2 Germline Mutations in Colombian Breast Cancer Patients.Sci Rep2017 Jul 5Torres Ddoi: 10.1038/s41598-017-05056-y.
25948675BRCAPRO 6.0 Model Validation in Male Patients Presenting for BRCA Testing.Oncologist2015 JunMitri ZIdoi: 10.1634/theoncologist.2014-0425
18241344Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics.Breast Cancer Res2008Wright MHdoi: 10.1186/bcr1855
22136207Association of BRCA1 functional single nucleotide polymorphisms with risk of differentiated thyroid carcinoma.Thyroid2012 JanXu Ldoi: 10.1089/thy.2011.0117
16998791Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients.Int J Cancer2006 Dec 15Rashid MU-
24519767Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis.BMJ2014 Feb 11Metcalfe Kdoi: 10.1136/bmj.g226.
15936476[Molecular alterations in breast cancer: clinical implications and new analytical tools].Rev Med Interne2005 JunGonalves A-
18030615High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer.Breast Cancer Res Treat2008 Octvan der Groep P-
20077502Cancer predisposing missense and protein truncating BARD1 mutations in non-BRCA1 or BRCA2 breast cancer families.Hum Mutat2010 MarDe Brakeleer Sdoi: 10.1002/humu.21200.
12440810Risk factors for ovarian cancer and early-onset breast cancer in Mongolia.Eur J Gynaecol Oncol2002Elit L-
18355772Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.Am J Hum Genet2008 AprAntoniou ACdoi: 10.1016/j.ajhg.2008.02.008
21799032Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes.Cancer Res2011 Sep 1Rebbeck TRdoi: 10.1158/0008-5472.CAN-11-0773
20204502Penetrance of breast cancer, ovarian cancer and contralateral breast cancer in BRCA1 and BRCA2 families: high cancer incidence at older age.Breast Cancer Res Treat2010 Decvan der Kolk DMdoi: 10.1007/s10549-010-0805-3
23050611Is multiple SNP testing in BRCA2 and BRCA1 female carriers ready for use in clinical practice? Results from a large Genetic Centre in the UK.Clin Genet2013 JulIngham SLdoi: 10.1111/cge.12035
25849179Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.JAMA2015 Apr 7Rebbeck TRdoi: 10.1001/jama.2014.5985.
25403427The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females.BMC Cancer2014 Nov 17Al-Moghrabi Ndoi: 10.1186/1471-2407-14-830.
18312450Probability of BRCA1/2 mutation varies with ovarian histology: results from screening 442 ovarian cancer families.Clin Genet2008 AprEvans DGdoi: 10.1111/j.1399-0004.2008.00974.x
23935836Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases.PLoS One2013 Jul 23Blanco Adoi: 10.1371/journal.pone.0067538
18098285On the dynamics of breast tumor development in women carrying germline BRCA1 and BRCA2 mutations.Int J Cancer2008 Apr 15Simon R-
21410590Mutational screening of the BRCA1 gene in sporadic breast cancer in Kazakhstan population.Breast J2011 May-JunAkilzhanova Adoi: 10.1111/j.1524-4741.2011.01068.x
17557253[Analysis of the mutation of BRCA1 gene in 70 Uigur women breast cancer patients in Xinjiang].Zhonghua Yi Xue Yi Chuan Xue Za Zhi2007 JunFu XG-
23544013Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.PLoS Genet2013Couch FJdoi: 10.1371/journal.pgen.1003212
22443199Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers.J Intern Med2012 AprBarnes DRdoi: 10.1111/j.1365-2796.2011.02502.x.
26006218Prospective multicenter cohort study of estrogen and insulin-like growth factor system in BRCA mutation carriers.Cancer Causes Control2015 AugKim Jdoi: 10.1007/s10552-015-0601-9
21221768Risk of ipsilateral breast cancer in BRCA1 and BRCA2 mutation carriers.Breast Cancer Res Treat2011 MayMetcalfe Kdoi: 10.1007/s10549-010-1336-7
20852631A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.Nat Genet2010 OctAntoniou ACdoi: 10.1038/ng.669
21496870Human epidermal growth factor receptor 2, Na+/H+ exchanger regulatory factor 1, and breast cancer susceptibility gene-1 as new biomarkers for familial breast cancers.Hum Pathol2011 NovMangia Adoi: 10.1016/j.humpath.2011.01.010
20507347The contribution of founder mutations in BRCA1 to breast cancer in Belarus.Clin Genet2010 OctUglanitsa Ndoi: 10.1111/j.1399-0004.2010.01439.x.
17987791Germline BRCA1 mutation and survival analysis in familial breast cancer patients in Kerala; South India.J Exp Clin Cancer Res2007 SepVinodkumar B-
16271956Search for large genomic alterations of the BRCA1 gene in a Finnish population.Cancer Genet Cytogenet2005 NovLaurila E-
21598239Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and pancreatic cancer.Cancer2012 Jan 15Stadler ZKdoi: 10.1002/cncr.26191
18835712Mutation screening of the BRCA1 gene in sporadic breast cancer in southern Chinese populations.Breast2008 DecHaitian Zdoi: 10.1016/j.breast.2008.08.003
22729394A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers.Cancer Epidemiol Biomarkers Prev2012 AugDing YC-
12677558Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.Am J Hum Genet2003 MayAntoniou A-
18971141Occult fallopian tube cancer in a patient with BRCA1 breast cancer.J Minim Invasive Gynecol2008 Nov-DecBrown JV 3rddoi: 10.1016/j.jmig.2008.07.007.
21324516Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer.Gynecol Oncol2011 May 1Zhang Sdoi: 10.1016/j.ygyno.2011.01.020
12872263Founder mutation in the BRCA1 gene in Malay breast cancer patients from Singapore.Hum Mutat2003 AugLee AS-
20472656BRCA1, BRCA2 and CHEK2 c.1100 delC mutations in patients with double primaries of the breasts and/or ovaries.J Med Genet2010 AugEvans DGdoi: 10.1136/jmg.2009.075770
15345109BRCA1 mutations in a population-based study of breast cancer in Stockholm County.Genet Test2004 SummerMargolin S-
26625823Absence of 185delAG and 6174delT Mutations among Breast Cancer Patients of Eastern India.Asian Pac J Cancer Prev2015Chakraborty A-
21123638Identification and Management of Women With BRCA Mutations or Hereditary Predisposition for Breast and Ovarian Cancer.Mayo Clin Proc2010 DecPruthi Sdoi: 10.4065/mcp.2010.0414.
26467044Adjuvant radiotherapy for primary breast cancer in BRCA1 and BRCA2 mutation carriers and risk of contralateral breast cancer with special attention to patients irradiated at younger age.Breast Cancer Res Treat2015 NovDrooger J-
12815598A specific GFP expression assay, penetrance estimate, and histological assessment for a putative splice site mutation in BRCA1.Hum Mutat2003 JulSouthey MC-
20878485An exploration of the communication preferences regarding genetic testing in individuals from families with identified breast/ovarian cancer mutations.Fam Cancer2011 MarRatnayake Pdoi: 10.1007/s10689-010-9383-0.
24566764Large genomic rearrangement of BRCA1 and BRCA2 genes in familial breast cancer patients in Korea.Fam Cancer2014 JunCho JYdoi: 10.1007/s10689-014-9704-9.
18030340Negative selection on BRCA1 susceptibility alleles sheds light on the population genetics of late-onset diseases and aging theory.PLoS One2007 Nov 21Pavard S-
24191513[Characteristics of selected clinical features in BRCA1 mutation carriers affected with breast cancer undergoing preventive female genital tract surgeries].Ginekol Pol2013 SepMenkiszak J-
21614564Prevalence and characterization of BRCA1 and BRCA2 germline mutations in Chinese women with familial breast cancer.Breast Cancer Res Treat2012 AprZhang Jdoi: 10.1007/s10549-011-1596-x
17497966Cancer risks for Australian women with a BRCA1 or a BRCA2 mutation.ANZ J Surg2007 MaySuthers GK-
16912201Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers.Cancer Res2006 Aug 15Deans AJ-
17428325Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk.Breast Cancer Res2007Baynes C-
20840664Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study.BJU Int2011 JanMitra AVdoi: 10.1111/j.1464-410X.2010.09648.x
26467043Does the age of breast cancer diagnosis in first-degree relatives impact on the risk of breast cancer in BRCA1 and BRCA2 mutation carriers?Breast Cancer Res Treat2015 NovSemple J-
25337278Prevalence of BRCA1 gene mutation in breast cancer patients in Guangxi, China.Int J Clin Exp Pathol2014 Aug 15Sun L-
22113258Phenocopy breast cancer rates in Israeli BRCA1 BRCA2 mutation carrier families: is the risk increased in non-carriers?Breast Cancer Res Treat2012 AprBernholtz Sdoi: 10.1007/s10549-011-1886-3
19661094Missense polymorphisms in BRCA1 and BRCA2 and risk of breast and ovarian cancer.Cancer Epidemiol Biomarkers Prev2009 AugDombernowsky SLdoi: 10.1158/1055-9965.EPI-09-0447.
15986445Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers.Int J Cancer2005 Dec 20Cullinane CA-
21063910Two BRCA1/2 founder mutations in Jews of Sephardic origin.Fam Cancer2011 MarSagi Mdoi: 10.1007/s10689-010-9395-9.
23335114Methylation of breast cancer susceptibility gene 1 (BRCA1) predicts recurrence in patients with curatively resected stage I non-small cell lung cancer.Cancer2013 Feb 15Harada Hdoi: 10.1002/cncr.27754
17673924Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries.Mod Pathol2007 OctZhang Z-
22032251Genotype-phenotype correlations among BRCA1 4153delA and 5382insC mutation carriers from Latvia.BMC Med Genet2011 Oct 27Plakhins Gdoi: 10.1186/1471-2350-12-147.
19920816Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA).Br J Cancer2009 Dec 15Osorio Adoi: 10.1038/sj.bjc.6605416
19298662The prevalence of BRCA1 mutations among young women with triple-negative breast cancer.BMC Cancer2009 Mar 19Young SRdoi: 10.1186/1471-2407-9-86.
17520345Prognostic value of BRCA1 mutations in familial breast cancer patients affected by a second primary cancer.Fam Cancer2007Elsakov P-
14507240BRCA1, BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer families in South India.Asian Pac J Cancer Prev2003 Jul-SepRajkumar T-
21691706Clinical implications for BRCA gene mutation in breast cancer.Mol Biol Rep2012 MarXu Jdoi: 10.1007/s11033-011-1073-y
19372713Age at onset of bilateral breast cancer, the presence of hereditary BRCA1, BRCA2, CHEK2 gene mutations and positive family history of cancer.Onkologie2009 AprSkasko Edoi: 10.1159/000200930
23011509Evaluation of chromosome 6p22 as a breast cancer risk modifier locus in a follow-up study of BRCA2 mutation carriers.Breast Cancer Res Treat2012 NovStevens KNdoi: 10.1007/s10549-012-2255-6
24153343Dietary intake and breast cancer among carriers and noncarriers of BRCA mutations in the Korean Hereditary Breast Cancer Study.Am J Clin Nutr2013 DecKo KPdoi: 10.3945/ajcn.112.057760
24321281Effect of BRCA1 on epidermal growth factor receptor in ovarian cancer.J Exp Clin Cancer Res2013 Dec 9Li Ddoi: 10.1186/1756-9966-32-102.
21190077BRCA1 and BRCA2 germline mutations in Uruguayan breast and breast-ovarian cancer families. Identification of novel mutations and unclassified variants.Breast Cancer Res Treat2011 JulDelgado Ldoi: 10.1007/s10549-010-1320-2
27958297Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer.Nat Rev Clin Oncol2017 MayGeorge Adoi: 10.1038/nrclinonc.2016.191
28448241Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores.J Clin Oncol2017 Jul 10Lecarpentier Jdoi: 10.1200/JCO.2016.69.4935
28294317The spectrum of BRCA mutations and characteristics of BRCA-associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next-generation sequencing.Int J Cancer2017 Jul 1Lang GTdoi: 10.1002/ijc.30692
29058716Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.Nat Genet2017 DecMilne RLdoi: 10.1038/ng.3785
27767231Novel BRCA1 and BRCA2 Tumor Test as Basis for Treatment Decisions and Referral for Genetic Counselling of Patients with Ovarian Carcinomas.Hum Mutat2017 FebWeren RDdoi: 10.1002/humu.23137
27601588Intratumor Heterogeneity of Homologous Recombination Deficiency in Primary Breast Cancer.Clin Cancer Res2017 Mar 1von Wahlde MKdoi: 10.1158/1078-0432.CCR-16-0889
28562349MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer.Oncotarget2017 Jun 20Gao Sdoi: 10.18632/oncotarget.17816.
29511213Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.Nat Commun2018 Mar 6Hern??ndez Gdoi: 10.1038/s41467-018-03433-3.
28087643Tumor BRCA1 Reversion Mutation Arising during Neoadjuvant Platinum-Based Chemotherapy in Triple-Negative Breast Cancer Is Associated with Therapy Resistance.Clin Cancer Res2017 Jul 1Afghahi Adoi: 10.1158/1078-0432.CCR-16-2174
28490613The BRCA1 c. 5096G>A p.Arg1699Gln (R1699Q) intermediate risk variant: breast and ovarian cancer risk estimation and recommendations for clinical management from the ENIGMA consortium.J Med Genet2018 JanMoghadasi Sdoi: 10.1136/jmedgenet-2017-104560
29338689Variants of cancer susceptibility genes in Korean BRCA1/2 mutation-negative patients with high risk for hereditary breast cancer.BMC Cancer2018 Jan 16Park JSdoi: 10.1186/s12885-017-3940-y.
29086229The yield of targeted genotyping for the recurring mutations in BRCA1/2 in Israel.Breast Cancer Res Treat2018 FebBernstein-Molho Rdoi: 10.1007/s10549-017-4551-7
29483665The association between cancer family history and ovarian cancer risk in BRCA1/2 mutation carriers: can it be explained by the mutation position?Eur J Hum Genet2018 JunTeixeira Ndoi: 10.1038/s41431-018-0111-9
30221688Expression and mutations of BRCA in breast cancer and ovarian cancer: Evidence from bioinformatics analyses.Int J Mol Med2018 DecWang Zdoi: 10.3892/ijmm.2018.3870
29335924BRCA1 and BRCA2 germline variants in breast cancer patients from the Republic of Macedonia.Breast Cancer Res Treat2018 AprJakimovska Mdoi: 10.1007/s10549-017-4642-5
29318406Prospective blinded surveillance screening of Swedish women with increased hereditary risk of breast cancer.Breast Cancer Res Treat2018 AprLiljegren Adoi: 10.1007/s10549-017-4639-0
29875420Written pretest information and germline BRCA1/2 pathogenic variant testing in unselected breast cancer patients: predictors of testing uptake.Genet Med2019 JanNilsson MPdoi: 10.1038/s41436-018-0021-9
30804502H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.Nat Cell Biol2019 MarNakamura Kdoi: 10.1038/s41556-019-0282-9
22253870BRCAness profile of sporadic ovarian cancer predicts disease recurrence.PLoS One2012Wysham WZdoi: 10.1371/journal.pone.0030042
21978880Contribution of epigenetic alteration of BRCA1 and BRCA2 genes in breast carcinomas in Tunisian patients.Cancer Epidemiol2012 AprBen Gacem Rdoi: 10.1016/j.canep.2011.09.001
20216074Hereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2.Genet Med2010 MayPetrucelli Ndoi: 10.1097/GIM.0b013e3181d38f2f.
23232912Frequency of 5382insC mutation of BRCA1 gene among breast cancer patients: an experience from Eastern India.Fam Cancer2013 SepChakraborty Adoi: 10.1007/s10689-012-9590-y.
19372557Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers.Mol Cancer Ther2009 AprSantarosa Mdoi: 10.1158/1535-7163.MCT-08-0951.
26426992First description of a sporadic breast cancer in a woman with BRCA1 germline mutation.Oncotarget2015 Nov 3Curtit Edoi: 10.18632/oncotarget.5348.
25824734The spectrum of genetic mutations in breast cancer.Asian Pac J Cancer Prev2015Sheikh A-
24770866BRCA1 founder mutations compared to ovarian cancer in Belarus.Fam Cancer2014 SepSavanevich Adoi: 10.1007/s10689-014-9721-8.
24528374Recurrent mutations of BRCA1 and BRCA2 in Poland: an update.Clin Genet2015 MarSzwiec Mdoi: 10.1111/cge.12360
17688236Contribution of BRCA1 and BRCA2 mutations to inherited ovarian cancer.Hum Mutat2007 DecRamus SJ-
21643751Common BRCA1 and BRCA2 mutations in breast cancer families: a meta-analysis from systematic review.Mol Biol Rep2012 MarWang Fdoi: 10.1007/s11033-011-0958-0
19016756Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer.Cancer Sci2008 OctSugano Kdoi: 10.1111/j.1349-7006.2008.00944.x.
21119070Allelic imbalance in BRCA1 and BRCA2 gene expression and familial ovarian cancer.Cancer Epidemiol Biomarkers Prev2011 JanShen Jdoi: 10.1158/1055-9965.EPI-10-0720
18695886BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model.Int J Oncol2008 SepYu X-
24145998BRCA1/2 and clinical outcome in a monoinstitutional cohort of women with hereditary breast cancer.Oncol Rep2014 JanSambiasi Ddoi: 10.3892/or.2013.2802
19246281[Analysis of BRCA1 gene mutations in patients with early-onset breast cancer and their affected relatives in Guangdong province].Nan Fang Yi Ke Da Xue Xue Bao2009 FebZhou J-
20638108Identification of point mutations and large rearrangements in the BRCA1 gene in 667 Turkish unselected ovarian cancer patients.Gynecol Oncol2010 OctAktas Ddoi: 10.1016/j.ygyno.2010.05.018
23846919BRCA and pancreatic cancer.JOP2013 Jul 10Brennan GTdoi: 10.6092/1590-8577/1652.
24625110A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.Breast Cancer Res2014 Mar 14McMullin RPdoi: 10.1186/bcr3625.
22425665BRCA1 and BRCA2 germline mutations in Moroccan breast/ovarian cancer families: novel mutations and unclassified variants.Gynecol Oncol2012 JunTazzite Adoi: 10.1016/j.ygyno.2012.03.007
20234119Effect of genetic counseling and testing for BRCA1 and BRCA2 mutations in African American women: a randomized trial.Public Health Genomics2010Halbert CHdoi: 10.1159/000293990
24600974Association of BRCA1 K1183R polymorphism with survival in BRCA1/2-negative chinese familial breast cancer.Clin Lab2014Pei R-
22262859The C-terminal proteolytic fragment of the breast cancer susceptibility type 1 protein (BRCA1) is degraded by the N-end rule pathway.J Biol Chem2012 Mar 2Xu Zdoi: 10.1074/jbc.M111.301002
25372568Breast cancer following ovarian cancer in BRCA mutation carriers.JAMA Surg2014 DecGangi Adoi: 10.1001/jamasurg.2014.1081.
17319787The spectrum and incidence of BRCA1 pathogenic mutations in Slovak breast/ovarian cancer families.Neoplasma2007Konecny M-
26010302Frequent incidence of BARD1-truncating mutations in germline DNA from triple-negative breast cancer patients.Clin Genet2016 MarDe Brakeleer Sdoi: 10.1111/cge.12620
23532817Evidence for predictive role of BRCA1 and bTUBIII in gastric cancer.Med Oncol2013 JunMoiseyenko VMdoi: 10.1007/s12032-013-0545-4
20467918ERCC1, RRM1 and BRCA1 mRNA expression levels and clinical outcome of advanced non-small cell lung cancer.Med Oncol2011 DecSu Cdoi: 10.1007/s12032-010-9553-9
23730208BRCA1 expression is epigenetically repressed in sporadic ovarian cancer cells by overexpression of C-terminal binding protein 2.Neoplasia2013 JunMay T-
17470134Identification of novel BRCA large genomic rearrangements in Singapore Asian breast and ovarian patients with cancer.Clin Genet2007 AprLim YK-
25267367Neurofibromatosis with male breast cancer--risk factor or co-incidence? Report of two rare cases.Breast Dis2015Tandon Mdoi: 10.3233/BD-140387.
18094425BRCA1 mRNA expression levels predict for overall survival in ovarian cancer after chemotherapy.Clin Cancer Res2007 Dec 15Quinn JE-
20384635Osteopontin can act as an effector for a germline mutation of BRCA1 in malignant transformation of breast cancer-related cells.Cancer Sci2010 JunEl-Tanani MKdoi: 10.1111/j.1349-7006.2010.01561.x
18400253Expression of BRCA1 protein in breast cancer and its prognostic significance.Hum Pathol2008 JunRakha EAdoi: 10.1016/j.humpath.2007.10.011
22311183Changes in the expression of plasma proteins associated with thrombosis in BRCA1 mutation carriers.J Cancer Res Clin Oncol2012 MayCustodio Adoi: 10.1007/s00432-012-1161-y
20514903[The prevalence of BRCA1 mutations among families at high-risk of breast and ovarian cancer in province of Malopolska between 2004-2009].Przegl Lek2009Blecharz P-
15447980Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers.Clin Cancer Res2004 Sep 15Zuhlke KA-
23172369BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies.Cell Cycle2012 Dec 1Martinez-Outschoorn UEdoi: 10.4161/cc.22776
15168169Identification and evaluation of 55 genetic variations in the BRCA1 and the BRCA2 genes of patients from 50 Japanese breast cancer families.J Hum Genet2004Kawahara M-
18752448BRCA1/2 in high-risk African American women with breast cancer: providing genetic testing through various recruitment strategies.Genet Test2008 SepPal Tdoi: 10.1089/gte.2007.0108.
22652532Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms.J Med Genet2012 JulSchulz Edoi: 10.1136/jmedgenet-2011-100674
21890493Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers.Hum Mol Genet2011 Dec 1Cox DGdoi: 10.1093/hmg/ddr388
22591913Tissue-based predictors of germ-line BRCA1 mutations: implications for triaging of genetic testing.Hum Pathol2012 Novde la Cruz Jdoi: 10.1016/j.humpath.2012.02.002
17761984Primary fallopian tube malignancies in BRCA-positive women undergoing surgery for ovarian cancer risk reduction.J Clin Oncol2007 Sep 1Callahan MJ-
24526546MRI volumetric analysis of breast fibroglandular tissue to assess risk of the spared nipple in BRCA1 and BRCA2 mutation carriers.Ann Surg Oncol2014 MayBaltzer HLdoi: 10.1245/s10434-014-3532-x
22753153Identification of fifteen novel germline variants in the BRCA1 3'UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site.Hum Mutat2012 DecBrewster BLdoi: 10.1002/humu.22159
20306497Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.Mol Carcinog2010 JunYarden RIdoi: 10.1002/mc.20618.
18095154Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.Breast Cancer Res Treat2008 NovWalker LC-
23066998Parental origin of mutation and the risk of breast cancer in a prospective study of women with a BRCA1 or BRCA2 mutation.Clin Genet2013 JulSenst Ndoi: 10.1111/cge.12037
24629213Polymorphisms in phase I and phase II genes and breast cancer risk and relations to persistent organic pollutant exposure: a case-control study in Inuit women.Environ Health2014 Mar 16Ghisari Mdoi: 10.1186/1476-069X-13-19.
25273865Wild-type genotypes of BRCA1 gene SNPs combined with micro-RNA over-expression in mammary tissue leading to familial breast cancer with an increased risk of distant metastases' occurrence.Med Oncol2014 NovMedimegh Idoi: 10.1007/s12032-014-0255-6
21918853Low prevalence of BRCA1 and BRCA2 mutations in the sporadic breast cancer of Spanish population.Fam Cancer2012 Marde Juan Jim??nez Idoi: 10.1007/s10689-011-9481-7.
19863560The contribution of founder mutations to early-onset breast cancer in French-Canadian women.Clin Genet2009 NovGhadirian Pdoi: 10.1111/j.1399-0004.2009.01277.x.
18559594BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a population-based series of ovarian cancer cases from Denmark.Clin Cancer Res2008 Jun 15Soegaard Mdoi: 10.1158/1078-0432.CCR-07-4806.
17719744Identification and in silico analysis of functional SNPs of the BRCA1 gene.Genomics2007 OctRajasekaran R-
18285832Uptake of testing for BRCA1/2 mutations in South East Scotland.Eur J Hum Genet2008 AugHolloway SMdoi: 10.1038/ejhg.2008.17
23483928Polymorphic repeat length in the AIB1 gene and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a meta-analysis of observational studies.PLoS One2013Bianco Adoi: 10.1371/journal.pone.0057781
22034289High prevalence of BRCA1 and BRCA2 mutations in unselected Nigerian breast cancer patients.Int J Cancer2012 Sep 1Fackenthal JDdoi: 10.1002/ijc.27326
18092194High prevalence of BRCA1 and BRCA2 mutations in unselected Nigerian breast cancer patients.Int J Cancer2012 Sep 1Fackenthal JDdoi: 10.1002/ijc.27326
25919761Results of a population-based screening for hereditary breast cancer in a region of North-Central Italy: contribution of BRCA1/2 germ-line mutations.Breast Cancer Res Treat2008 NovSeymour IJ-
22569005Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers.Breast Cancer Res2014 Dec 31Kuchenbaecker KBdoi: 10.1186/s13058-014-0492-9.
26727920DNA-testing for BRCA1/2 prior to genetic counselling in patients with breast cancer: design of an intervention study, DNA-direct.BMC Womens Health2012 May 8Sie ASdoi: 10.1186/1472-6874-12-12.
25948282Statewide Retrospective Review of Familial Pancreatic Cancer in Delaware, and Frequency of Genetic Mutations in Pancreatic Cancer Kindreds.Ann Surg Oncol2016 MayCatts ZAdoi: 10.1245/s10434-015-5026-x
20455026New recurrent BRCA1/2 mutations in Polish patients with familial breast/ovarian cancer detected by next generation sequencing.BMC Med Genomics2015 May 7Kluska Adoi: 10.1186/s12920-015-0092-2.
17426707Identification of a Danish breast/ovarian cancer family double heterozygote for BRCA1 and BRCA2 mutations.Fam Cancer2010 SepSteffensen AYdoi: 10.1007/s10689-010-9345-6.
20820192No efficacy of annual gynaecological screening in BRCA1/2 mutation carriers; an observational follow-up study.Br J Cancer2007 May 7Hermsen BB-
19012246BRCA1 affects global DNA methylation through regulation of DNMT1.Cell Res2010 NovShukla Vdoi: 10.1038/cr.2010.128
17922413BRCA1 expression and molecular alterations in familial breast cancer.Histol Histopathol2009 JanMangia Adoi: 10.14670/HH-24.69.
25437005[BRCA1 germ line mutations in Chinese early-onset breast cancer patients].Zhonghua Yi Xue Yi Chuan Xue Za Zhi2007 OctLi WF-
27129401A genomic instability score in discriminating nonequivalent outcomes of BRCA1/2 mutations and in predicting outcomes of ovarian cancer treated with platinum-based chemotherapy.PLoS One2014 Dec 1Zhang Sdoi: 10.1371/journal.pone.0113169
15803125Clinical and pathological features of BRCA1/2 tumors in a sample of high-risk Moroccan breast cancer patients.BMC Res Notes2016 Apr 29Jouhadi Hdoi: 10.1186/s13104-016-2057-8.
26246475Promoter usage of BRCA1-IRIS.Nat Cell Biol2005 AprKvist A-
15131401Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes.Oncotarget2015 Sep 22Cochran RLdoi: 10.18632/oncotarget.4595.
25129345BRCA1 testing in breast and/or ovarian cancer families from northeastern France identifies two common mutations with a founder effect.Fam Cancer2004Muller D-
16567799Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients.Breast Cancer Res Treat2014 SepByrski Tdoi: 10.1007/s10549-014-3100-x
24518526BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells.J Biol Chem2006 May 26Kang HJ-
21989927BRCA mutations in prostate cancer patients.Clin Adv Hematol Oncol2013Olmos D-
21666725Contribution of germline mutations in the BRCA and PALB2 genes to pancreatic cancer in Italy.Fam Cancer2012 MarGhiorzo Pdoi: 10.1007/s10689-011-9483-5.
23982851Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation.Oncogene2012 Jan 5Lee MHdoi: 10.1038/onc.2011.217
18521744Association of BRCA1 germline mutations in young onset triple-negative breast cancer (TNBC).Clin Transl Oncol2014 MarAndr??s Rdoi: 10.1007/s12094-013-1070-9
17952592BRCA1 promoter methylation is associated with increased mortality among women with breast cancer.Breast Cancer Res Treat2009 MayXu Xdoi: 10.1007/s10549-008-0075-5
21553119Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients.Breast Cancer Res Treat2008 SepKriege M-
15170666Prevalence of BRCA1/2 mutations in sporadic breast/ovarian cancer patients and identification of a novel de novo BRCA1 mutation in a patient diagnosed with late onset breast and ovarian cancer: implications for genetic testing.Breast Cancer Res Treat2012 FebDe Leeneer Kdoi: 10.1007/s10549-011-1544-9
24629067The variant E233G of the RAD51D gene could be a low-penetrance allele in high-risk breast cancer families without BRCA1/2 mutations.Int J Cancer2004 Jul 20Rodr??guez-L??pez R-
26698676Glucocorticoid receptor repression mediated by BRCA1 inactivation in ovarian cancer.BMC Cancer2014 Mar 14Fang YYdoi: 10.1186/1471-2407-14-188.
20487263Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.Fertil Steril2016 MarGronwald Jdoi: 10.1016/j.fertnstert.2015.11.034
20804917Aberrant methylation of breast and ovarian cancer susceptibility gene 1 in chemosensitive human ovarian cancer cells does not involve the phosphatidylinositol 3'-kinase-Akt pathway.Cancer Sci2010 JulWang YQdoi: 10.1111/j.1349-7006.2010.01568.x
26183948Novel BRCA1/2 mutations in Serbian breast and breast-ovarian cancer patients with hereditary predisposition.Cancer Genet Cytogenet2010 Oct 1Dobrici Jdoi: 10.1016/j.cancergencyto.2010.06.001.
15723343Spectrum and frequencies of BRCA1/2 mutations in Bulgarian high risk breast cancer patients.BMC Cancer2015 Jul 17Dodova RIdoi: 10.1186/s12885-015-1516-2.
24458845 in gene expression and genetic integrity.J Cell Biochem2005 Apr 15Aiyar S-
27221860Timing of oral contraceptive use and the risk of breast cancer in BRCA1 mutation carriers.Breast Cancer Res Treat2014 FebKotsopoulos Jdoi: 10.1007/s10549-013-2823-4
22120723A Pilot Study on Screening of BRCA1 Mutations (185delAG, 1294del40) in Nepalese Breast Cancer Patients.Asian Pac J Cancer Prev2016Bhatta B-
25579682BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers.Oncogene2012 Aug 9Tkocz Ddoi: 10.1038/onc.2011.531
17968145FMR1 CGG allele length in Israeli BRCA1/BRCA2 mutation carriers and the general population display distinct distribution patterns.Genet Res (Camb)2014 Oct 8Laitman Ydoi: 10.1017/S0016672314000147.
23877192High frequency of BRCA1/2 and p53 somatic inactivation in sporadic ovarian cancer.J Genet2007 AugZikan M-
23982256Detection of new point mutations of BRCA1 and BRCA2 in breast cancer patients.Biochem Genet2014 FebBensam Mdoi: 10.1007/s10528-013-9623-8
22402307Total skin-sparing mastectomy in BRCA mutation carriers.Ann Surg Oncol2014 JanPeled AWdoi: 10.1245/s10434-013-3230-0
20652397BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls.Cancer Epidemiol2012 JunBosviel Rdoi: 10.1016/j.canep.2012.02.001
19035454The CASP8 rs3834129 polymorphism and breast cancer risk in BRCA1 mutation carriers.Breast Cancer Res Treat2011 FebCatucci Idoi: 10.1007/s10549-010-1068-8
23110154The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer.Int J Cancer2009 Feb 15Weberpals Jdoi: 10.1002/ijc.23987.
26195121Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.PLoS One2012Pern Fdoi: 10.1371/journal.pone.0047993
12237281Breast cancer risk for Korean women with germline mutations in BRCA1 and BRCA2.Breast Cancer Res Treat2015 AugPark Bdoi: 10.1007/s10549-015-3495-z
21336637Cancer Incidence in BRCA1 mutation carriers.J Natl Cancer Inst2002 Sep 18Thompson D-
26700119Expression of the stem cell marker ALDH1 in BRCA1 related breast cancer.Cell Oncol (Dordr)2011 FebHeerma van Voss MRdoi: 10.1007/s13402-010-0007-3
25722380Impact of Age at Primary Breast Cancer on Contralateral Breast Cancer Risk in BRCA1/2 Mutation Carriers.J Clin Oncol2016 Feb 10van den Broek AJdoi: 10.1200/JCO.2015.62.3942
19656998Effect of BRCA1 and XPG mutations on treatment response to trabectedin and pegylated liposomal doxorubicin in patients with advanced ovarian cancer: exploratory analysis of the phase 3 OVA-301 study.Ann Oncol2015 MayMonk BJdoi: 10.1093/annonc/mdv071
23257159Elucidation of the transmission of a novel mutation in BRCA1 (1125delCT) in a family with multiple cases of breast cancer.Cancer Genomics Proteomics2009 Jul-AugRazis E-
24258259Long-term ovarian cancer survival associated with mutation in BRCA1 or BRCA2.J Natl Cancer Inst2013 Jan 16McLaughlin JRdoi: 10.1093/jnci/djs494
19877752Promoter methylation of BRCA1 in the prognosis of breast cancer: a meta-analysis.Breast Cancer Res Treat2013 DecWu Ldoi: 10.1007/s10549-013-2774-9
20215541Analysis of BRCA1 and BRCA2 mutations in southern Iranian Breast cancer patients.Arch Iran Med2009 NovFattahi MJ-
22901997A high proportion of DNA variants of BRCA1 and BRCA2 is associated with aberrant splicing in breast/ovarian cancer patients.Clin Cancer Res2010 Mar 15Sanz DJdoi: 10.1158/1078-0432.CCR-09-2564
16914727[BRCA1: a new predictive genomic marker for chemotherapy and radiotherapy of non-small cell lung cancer].Zhongguo Fei Ai Za Zhi2012 AugLi Mdoi: 10.3779/j.issn.1009-3419.2012.08.06.
22673632Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1.Mol Cell Biol2006 SepMuraoka-Cook RS-
18071589BRCAness: finding the Achilles heel in ovarian cancer.Oncologist2012Rigakos Gdoi: 10.1634/theoncologist.2012-0028
23842040Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells.Int J Biol Sci2007 Nov 26Aiyar SE-
12938098Functional analysis of BRCA1 missense variants of uncertain significance in Japanese breast cancer families.J Hum Genet2013 SepKawaku Sdoi: 10.1038/jhg.2013.71
18286383Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families in Southern Germany.Hum Mutat2003 SepMeyer P-
25971130Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba.Fam Cancer2008Rodriguez RCdoi: 10.1007/s10689-008-9187-7
23082475[Ethnic aspects of hereditary breast cancer in the region of Siberia].Vestn Ross Akad Med Nauk2014Cherdyntseva NV-
20103632Detection of BRCA1 and BRCA2 gene mutation in Egyptian females with breast cancer and their relatives by PCR-SSCP method.Egypt J Immunol2011Fattouh M-
23469205BRCA1 represses amphiregulin gene expression.Cancer Res2010 Feb 1Lamber EPdoi: 10.1158/0008-5472.CAN-09-2842
18060494Comprehensive analysis of BRCA1, BRCA2 and TP53 germline mutation and tumor characterization: a portrait of early-onset breast cancer in Brazil.PLoS One2013Carraro DMdoi: 10.1371/journal.pone.0057581
21455666Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families of Eastern Spain.Breast Cancer Res Treat2008 NovEsteban Cardeosa E-
25777348The impact of contralateral mastectomy on mortality in BRCA1 and BRCA2 mutation carriers with breast cancer.Breast Cancer Res Treat2011 JulNarod SAdoi: 10.1007/s10549-011-1479-1
25971625BRCA1 and BRCA2 mutations in ethnic Lebanese Arab women with high hereditary risk breast cancer.Oncologist2015 AprEl Saghir NSdoi: 10.1634/theoncologist.2014-0364
17020472Evaluation of BRCA1/2 mutational status among German and Austrian women with triple-negative breast cancer.J Cancer Res Clin Oncol2015 NovMuendlein Adoi: 10.1007/s00432-015-1986-2
12353262The P1812A and P25T BRCA1 and the 5164del4 BRCA2 mutations: occurrence in high-risk non-Ashkenazi Jews.Genet Test2006 FallKaufman B-
20371364Subcellular localization of the BRCA1 gene product in mitotic cells.Genes Chromosomes Cancer2002 NovLotti LV-
23276146BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions.Chem Biol Interact2010 Nov 5Hair JMdoi: 10.1016/j.cbi.2010.03.046
24489760The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients.Diagn Pathol2012 Dec 31Zhang Qdoi: 10.1186/1746-1596-7-181.
23704879Telomere length shows no association with BRCA1 and BRCA2 mutation status.PLoS One2014 Jan 29Killick Edoi: 10.1371/journal.pone.0086659
16792513Missense variants of uncertain significance (VUS) altering the phosphorylation patterns of BRCA1 and BRCA2.PLoS One2013 May 21Tram Edoi: 10.1371/journal.pone.0062468
22116506No Evidence of BRCA1/2 genomic rearrangements in high-risk French-Canadian breast/ovarian cancer families.Genet Test2006 SummerMoisan AM-
20570322Somatic mutations in the BRCA1 gene in Chinese women with sporadic breast cancer.Breast Cancer Res Treat2012 FebZhang Mdoi: 10.1007/s10549-011-1887-2
20376556Prevalence of BRCA1 and BRCA2 germ line mutations among women with carcinoma of the fallopian tube.Gynecol Oncol2010 SepVicus Ddoi: 10.1016/j.ygyno.2010.05.011
12453858Effect of BRCA1/2 mutation on short-term and long-term breast cancer survival: a systematic review and meta-analysis.Breast Cancer Res Treat2010 JulLee EHdoi: 10.1007/s10549-010-0859-2
21520156BRCA1 and BRCA2 germline mutations in Sardinian breast cancer families and their implications for genetic counseling.Ann Oncol2002 DecPalmieri G-
18269736BRCA1 mutations do not increase prostate cancer risk: results from a meta-analysis including new data.Prostate2011 DecFachal Ldoi: 10.1002/pros.21394
26378051BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype.Breast Cancer Res2008Snell Cdoi: 10.1186/bcr1858
17851763miRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers.Oncotarget2015 Oct 13Vos Sdoi: 10.18632/oncotarget.5617.
24081797The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified.Breast Cancer Res Treat2008 JulLi WF-
12647291Ovarian cancer in BRCA mutation carriers: improved outcome after intraperitoneal (IP) cisplatin.Ann Surg Oncol2014 MayKwa Mdoi: 10.1245/s10434-013-3277-y
27002934Breast cancer gene 1 (BRCA1): role in cell cycle regulation and DNA repair--perhaps through transcription.J Cell Biochem2003 Apr 15Somasundaram K-
16998496Phase 2 multicentre trial investigating intermittent and continuous dosing schedules of the poly(ADP-ribose) polymerase inhibitor rucaparib in germline BRCA mutation carriers with advanced ovarian and breast cancer.Br J Cancer2016 Mar 29Drew Ydoi: 10.1038/bjc.2016.41
23350388Clinical management of BRCA1 and BRCA2 mutation carriers.Oncogene2006 Sep 25Domchek SM-
25447904[Loss of heterozygosity (LOH) at BRCA1 loci in primary breast cancers].Nihon Rinsho2012 SepMiyoshi Y-
25342642Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes.Gene2015 Feb 1Zhong Qdoi: 10.1016/j.gene.2014.11.009
19383373Limited family structure and triple-negative breast cancer (TNBC) subtype as predictors of BRCA mutations in a genetic counseling cohort of early-onset sporadic breast cancers.Breast Cancer Res Treat2014 NovZugazagoitia Jdoi: 10.1007/s10549-014-3167-4
21196292Thematic issue on the molecular biology of hereditary ovarian cancer. Preface.Mol Oncol2009 AprTonin PNdoi: 10.1016/j.molonc.2009.02.002
25041116BRCA1-related gene signature in breast cancer: the role of ER status and molecular type.Front Biosci (Elite Ed)2011 Jan 1Lisowska KM-
24889916Analysis of novel mutations in BRCA1 in Iranian families with breast cancer.Hereditas2014 JunSadr-Nabavi Adoi: 10.1111/hrd2.00040.
17321670BRCA1 gene promoter methylation status in high-grade serous ovarian cancer patients--a study of the tumour Bank ovarian cancer (TOC) and ovarian cancer diagnosis consortium (OVCAD).Eur J Cancer2014 AugRuscito Idoi: 10.1016/j.ejca.2014.05.001
18762988Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines.Cancer Lett2007 Aug 8Burkitt K-
26742938Germline BRCA1 mutations predispose to pancreatic adenocarcinoma.Hum Genet2008 OctAl-Sukhni Wdoi: 10.1007/s00439-008-0554-0
21769658Germline BRCA testing is moving from cancer risk assessment to a predictive biomarker for targeting cancer therapeutics.Clin Transl Oncol2016 OctMoreno Ldoi: 10.1007/s12094-015-1470-0
16168118Characterization of BRCA1 and BRCA2 splicing variants: a collaborative report by ENIGMA consortium members.Breast Cancer Res Treat2012 AprThomassen Mdoi: 10.1007/s10549-011-1674-0
26919240High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area.Breast Cancer Res2005Pohlreich P-
20567915miR-342 overexpression results in a synthetic lethal phenotype in BRCA1-mutant HCC1937 breast cancer cells.Oncotarget2016 Apr 5Crippa Edoi: 10.18632/oncotarget.7617.
21735045Complete BRCA mutation screening in breast and ovarian cancer predisposition families from a North-Eastern Romanian population.Fam Cancer2010 DecNegura Ldoi: 10.1007/s10689-010-9361-6.
22252577Assessing the RNA effect of 26 DNA variants in the BRCA1 and BRCA2 genes.Breast Cancer Res Treat2012 AprMen??ndez Mdoi: 10.1007/s10549-011-1661-5
17697535The relevance of BRCA genetics to prostate cancer pathogenesis and treatment.Clin Adv Hematol Oncol2011 OctSundararajan S-
23614934A mutation in the 5' untranslated region of the BRCA1 gene in sporadic breast cancer causes downregulation of translation efficiency.J Int Med Res2007 Jul-AugWang J-
18205043Prediction of BRCA1 germ-line mutation status in patients with breast cancer using histoprognosis grade, MS110, Lys27H3, vimentin, and KI67.Pathobiology2013Hassanein Mdoi: 10.1159/000339432
15876585Early radiation exposures and BRCA1-associated breast cancer in young women from Poland.Breast Cancer Res Treat2008 DecGronwald Jdoi: 10.1007/s10549-008-9892-9
22076508Mutational analysis of the BRCA1 gene in 30 Czech ovarian cancer patients.J Genet2005 AprZikan M-
18662409Methylation profiles of the BRCA1 promoter in hereditary and sporadic breast cancer among Han Chinese.Med Oncol2012 SepPang Ddoi: 10.1007/s12032-011-0100-0
17922257Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA1 gene in Sri Lankan breast cancer patients and at risk individuals.BMC Cancer2008 Jul 29De Silva Wdoi: 10.1186/1471-2407-8-214.
25586199Contribution of the BRCA1 and BRCA2 mutations to breast cancer in Tunisia.J Hum Genet2007Troudi W-
19383374Two novel frameshift mutations in BRCA2 gene detected by next generation sequencing in a survey of Spanish patients of breast cancer.Clin Transl Oncol2015 JulHernan Idoi: 10.1007/s12094-014-1271-x
21425892Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management.Mol Oncol2009 AprLynch HTdoi: 10.1016/j.molonc.2009.02.004
23146957Report of Endometrial Cancer in Australian BRCA1 and BRCA2 mutation-positive Families.Twin Res Hum Genet2011 AprDuffy DLdoi: 10.1375/twin.14.2.111.
23415752X chromosome inactivation pattern in BRCA gene mutation carriers.Eur J Cancer2013 MarManoukian Sdoi: 10.1016/j.ejca.2012.10.013
18158280BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.Mol Oncol2013 JunStordal Bdoi: 10.1016/j.molonc.2012.12.007
23928241Similar prevalence of founder BRCA1 and BRCA2 mutations among Ashkenazi and non-Ashkenazi men with breast cancer: evidence from 261 cases in Israel, 1976-1999.Eur J Med Genet2008 Mar-AprChodick G-
25070656Breast magnetic resonance imaging for screening high-risk women.Magn Reson Imaging Clin N Am2013 AugSung JSdoi: 10.1016/j.mric.2013.02.006
20177704From the set-up of a screening program of breast cancer patients to the identification of the first BRCA mutation in the DR Congo.BMC Public Health2014 Jul 28Luyeye Mvila Gdoi: 10.1186/1471-2458-14-759.
26187060Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer.J Cancer Res Clin Oncol2010 NovBozhanov SSdoi: 10.1007/s00432-010-0824-9
21898151Comprehensive spectrum of BRCA1 and BRCA2 deleterious mutations in breast cancer in Asian countries.J Med Genet2016 JanKwong Adoi: 10.1136/jmedgenet-2015-103132
20458532Non-cancer endpoints in BRCA1/2 carriers after risk-reducing salpingo-oophorectomy.Fam Cancer2012 MarCohen JVdoi: 10.1007/s10689-011-9480-8.
16843109No evidence of excess breast cancer risk among mutation-negative women from BRCA mutation-positive families.Breast Cancer Res Treat2011 JanKorde LAdoi: 10.1007/s10549-010-0923-y
20807450Low frequency of large genomic rearrangements of BRCA1 and BRCA2 in western Denmark.Cancer Genet Cytogenet2006 Jul 15Thomassen M-
18645608Comparing the frequency of common genetic variants and haplotypes between carriers and non-carriers of BRCA1 and BRCA2 deleterious mutations in Australian women diagnosed with breast cancer before 40 years of age.BMC Cancer2010 Sep 1Turkovic Ldoi: 10.1186/1471-2407-10-466.
16331276BRCA1 mutations in Algerian breast cancer patients: high frequency in young, sporadic cases.Int J Med Sci2008 Jul 8Uhrhammer N-
21570976BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1).Oncogene2006 Mar 2Williamson EA-
15319244The BRCA1 ubiquitin ligase and homologous recombination repair.FEBS Lett2011 Sep 16Ohta Tdoi: 10.1016/j.febslet.2011.05.005
16760288BRCA1 and BRCA2 mutations as prognostic factors in bilateral breast cancer patients.Ann Oncol2004 SepRogozi??ska-Szczepka J-
26057449Y179C, F486L and N550H are BRCA1 variants that may be associated with breast cancer in a Sicilian family: results of a 5-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.Ann Oncol2006 JunAugello C-
27221885Association between cytosolic expression of BRCA1 and metastatic risk in breast cancer.Br J Cancer2015 Jul 28Santivasi WLdoi: 10.1038/bjc.2015.208
16998499Screening of BRCA1/2 Mutations Using Direct Sequencing in Indonesian Familial Breast Cancer Cases.Asian Pac J Cancer Prev2016Anwar SL-
17145961Basal-like breast cancer and the BRCA1 phenotype.Oncogene2006 Sep 25Turner NC-
22864640BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin.J Cell Biol2006 Dec 4Pageau GJ-
20848184High frequency of BRCA1 founder mutations in Polish women with nonfamilial breast cancer.Fam Cancer2012 DecGaj Pdoi: 10.1007/s10689-012-9560-4.
23317271Two novel variants in the 3'UTR of the BRCA1 gene in familial breast and/or ovarian cancer.Breast Cancer Res Treat2011 FebLheureux Sdoi: 10.1007/s10549-010-1165-8
18559571Screening of 185DelAG, 1014DelGT and 3889DelAG BRCA1 mutations in breast cancer patients from North-East India.Asian Pac J Cancer Prev2012Hansa J-
23657760Better life expectancy in women with BRCA2 compared with BRCA1 mutations is attributable to lower frequency and later onset of ovarian cancer.Cancer Epidemiol Biomarkers Prev2008 JunByrd LMdoi: 10.1158/1055-9965.EPI-07-2792.
15485898Association of the BRCA1 promoter polymorphism rs11655505 with the risk of familial breast and/or ovarian cancer.Fam Cancer2013 DecBielinska Bdoi: 10.1007/s10689-013-9647-6.
25531315Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.Mol Cell Biol2004 NovZimmerman ES-
23569316FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer.Oncogene2015 Sep 24Gong Cdoi: 10.1038/onc.2014.421
17180310Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer.J Clin Oncol2013 May 10Castro Edoi: 10.1200/JCO.2012.43.1882
26824983Genetic instability in the RAD51 and BRCA1 regions in breast cancer.Cell Mol Biol Lett2007Nowacka-Zawisza M-
22053997Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer.Oncotarget2016 Feb 16Lin PHdoi: 10.18632/oncotarget.7027.
15900600Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.Breast Cancer Res2011Mulligan AMdoi: 10.1186/bcr3052
12497638Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene.Int J Cancer2005 Nov 1Hughes DJ-
23407556BRCA1 germline mutations in Indian familial breast cancer.Hum Mutat2003 JanValarmathi MT-
22798144BRCA1, LMO4, and CtIP mRNA expression in erlotinib-treated non-small-cell lung cancer patients with EGFR mutations.J Thorac Oncol2013 MarKarachaliou Ndoi: 10.1097/JTO.0b013e31827db621.
18258506Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer.Breast Cancer Res Treat2012 AugKim Hdoi: 10.1007/s10549-012-2159-5
19484476The Fanconi anaemia/BRCA pathway and cancer susceptibility. Searching for new therapeutic targets.Clin Transl Oncol2008 FebGarc??a MJ-
18165637Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women.J Cancer Res Clin Oncol2009 NovHuo Xdoi: 10.1007/s00432-009-0604-6
15345110BRCA1 p.Val1688del is a deleterious mutation that recurs in breast and ovarian cancer families from Northeast Italy.J Clin Oncol2008 Jan 1Malacrida Sdoi: 10.1200/JCO.2007.13.2118.
21887486Characterization of two novel BRCA1 germ-line mutations involving splice donor sites.Genet Test2004 SummerBrose MS-
19671671BRCA1-mediated signaling pathways in ovarian carcinogenesis.Funct Integr Genomics2012 MarKarve TMdoi: 10.1007/s10142-011-0251-2
17160431Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.Mol Cancer Res2009 AugWillers Hdoi: 10.1158/1541-7786.MCR-09-0149
20215423Improved survival in BRCA2 carriers with ovarian cancer.Fam Cancer2007Pal T-
18782836Wild-type BRCA1, but not mutated BRCA1, regulates the expression of the nuclear form of beta-catenin.Mol Cancer Res2010 MarLi Hdoi: 10.1158/1541-7786.MCR-09-0403
19843326Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women.J Med Genet2009 JanChan KYdoi: 10.1136/jmg.2007.057174
20683152Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers.Breast Cancer Res2009Neuhausen SLdoi: 10.1186/bcr2414.
24797986BRCA1 and BRCA2 germline mutations screening in Algerian breast/ovarian cancer families.Dis Markers2010Cherbal Fdoi: 10.3233/DMA-2010-0718.
26869327BRCA1 gene-related hereditary susceptibility to breast and ovarian cancer in Latvia.Adv Med Sci2014 MarTihomirova Ldoi: 10.1016/j.advms.2013.09.002
23624750Increased Reach of Genetic Cancer Risk Assessment as a Tool for Precision Management of Hereditary Breast Cancer.JAMA Oncol2016 Jun 1Blazer KRdoi: 10.1001/jamaoncol.2015.5975.
22333603Germline mutations in NF1 and BRCA1 in a family with neurofibromatosis type 1 and early-onset breast cancer.Breast Cancer Res Treat2013 JunCampos Bdoi: 10.1007/s10549-013-2538-6
21987798BRCA1 testing should be offered to individuals with triple-negative breast cancer diagnosed below 50 years.Br J Cancer2012 Mar 13Robertson Ldoi: 10.1038/bjc.2012.31
23409019Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.Proc Natl Acad Sci U S A2011 Oct 25Konishi Hdoi: 10.1073/pnas.1110969108
14722926Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles.PLoS One2013Gracia-Aznarez FJdoi: 10.1371/journal.pone.0055681
18256760Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families.Hum Mutat2004 FebValarmathi MT-
20513533High incidence of mutations in BRCA1 and BRCA2 genes in ovarian cancer.Bull Exp Biol Med2007 JulSmirnova TY-
21591024Interaction between BRCA1/BRCA2 and ATM/ATR associate with breast cancer susceptibility in a Chinese Han population.Cancer Genet Cytogenet2010 Jul 1Wang Kdoi: 10.1016/j.cancergencyto.2010.03.006.
20838878The rs2910164:G>C SNP in the MIR146A gene is not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.Hum Mutat2011 SepGarcia AIdoi: 10.1002/humu.21539
14701743A high prevalence of BRCA1 mutations among breast cancer patients from the Bahamas.Breast Cancer Res Treat2011 JanDonenberg Tdoi: 10.1007/s10549-010-1156-9
20840220Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.Mol Cell Biol2004 JanZhang J-
16837909Haplotype analysis of two recurrent genomic rearrangements in the BRCA1 gene suggests they are founder mutations for the Greek population.Clin Genet2011 OctPertesi Mdoi: 10.1111/j.1399-0004.2010.01532.x
19707196Analysis of RAD51 polymorphism and BRCA1 mutations in Polish women with breast cancer.Exp Oncol2006 JunRomanowicz-Makowska H-
24265793The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.Br J Cancer2009 Oct 20Sinilnikova OMdoi: 10.1038/sj.bjc.6605279
26515461Tumor mutation burden forecasts outcome in ovarian cancer with BRCA1 or BRCA2 mutations.PLoS One2013 Nov 12Birkbak NJdoi: 10.1371/journal.pone.0080023
26269803BRCA1/2 mutations perturb telomere biology: characterization of structural and functional abnormalities in vitro and in vivo.Oncotarget2016 Jan 19Uziel Odoi: 10.18632/oncotarget.5693.
17582599Oophorectomy benefits in breast cancer patients with BRCA1 mutation.Post Reprod Health2015 JunBrown S-
21520273Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility.Int J Cancer2007 Oct 1Barwell J-
17612526Assessment of rare BRCA1 and BRCA2 variants of unknown significance using hierarchical modeling.Genet Epidemiol2011 JulCapanu Mdoi: 10.1002/gepi.20587
24591564Regulation of BRCA1 messenger RNA stability in human epithelial cell lines and during cell cycle progression.FEBS Lett2007 Jul 24Saunus JM-
25800897Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation.EMBO J2014 Apr 16Gardini Adoi: 10.1002/embj.201385567
22044689Epigenetic changes in BRCA1-mutated familial breast cancer.Cancer Genet2015 MayDowns Bdoi: 10.1016/j.cancergen.2015.02.001
25863477BRCA1 and BRCA2 mutations among ovarian cancer patients from Colombia.Gynecol Oncol2012 FebRodr??guez AOdoi: 10.1016/j.ygyno.2011.10.027
15591272The prevalence and spectrum of BRCA1 and BRCA2 mutations in Korean population: recent update of the Korean Hereditary Breast Cancer (KOHBRA) study.Breast Cancer Res Treat2015 MayKang Edoi: 10.1007/s10549-015-3377-4
20694749A protein truncating BRCA1 allele with a low penetrance of breast cancer.J Med Genet2004 DecGorski B-
20368571Comprehensive BRCA1 and BRCA2 mutation analyses and review of French Canadian families with at least three cases of breast cancer.Fam Cancer2010 DecCavallone Ldoi: 10.1007/s10689-010-9372-3.
22734169Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2.J Clin Oncol2010 May 10Malone KEdoi: 10.1200/JCO.2009.24.2495
18090912Recognizing BRCA gene mutation risk subsequent to breast cancer diagnosis in southwestern Ontario.Can Fam Physician2012 MayVanstone M-
21708937BRCA1 mutations and prostate cancer in Poland.Eur J Cancer Prev2008 FebCybulski C-
19839046Genetic variation in IGF2 and HTRA1 and breast cancer risk among BRCA1 and BRCA2 carriers.Cancer Epidemiol Biomarkers Prev2011 AugNeuhausen SLdoi: 10.1158/1055-9965.EPI-10-1336
21765473Genomic alterations in histopathologically normal breast tissue from BRCA1 mutation carriers may be caused by BRCA1 haploinsufficiency.Genes Chromosomes Cancer2010 JanRennstam Kdoi: 10.1002/gcc.20723.
27297669c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.Oncogene2012 Feb 16Regan JLdoi: 10.1038/onc.2011.289
23548269Germline mutations of BRCA1 gene exon 11 are not associated with platinum response neither with survival advantage in patients with primary ovarian cancer: understanding the clinical importance of one of the biggest human exons. A study of the Tumor Bank Ovarian Cancer (TOC) Consortium.Tumour Biol2016 SepDimitrova D-
24244370ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status.Cancer Res2013 Jun 15Huntoon CJdoi: 10.1158/0008-5472.CAN-13-0110
20919953An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.PLoS One2013 Nov 11Stead LFdoi: 10.1371/journal.pone.0078823
11857749Genomic large rearrangement screening of BRCA1 and BRCA2 genes in high-risk Turkish breast/ovarian cancer patients by using multiplex ligation-dependent probe amplification assay.Cancer Invest2011 JanManguolu Edoi: 10.3109/07357907.2010.512599
20809358Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a founder mutation of BRCA1 identified in the Chinese population.Hum Mutat2002 MarKhoo US-
19083511Association between mitogen-activated protein kinase kinase kinase 1 rs889312 polymorphism and breast cancer risk: evidence from 59,977 subjects.Breast Cancer Res Treat2011 AprLu PHdoi: 10.1007/s10549-010-1151-1
26254840Understanding genetic analysis for breast cancer and its implications for plastic surgery.Aesthet Surg J2008 Jan-FebSoltanian Hdoi: 10.1016/j.asj.2007.10.002.
11933198Screening for Genetic Testing in Breast Cancer - Are We Missing the Full Picture?Clin Oncol (R Coll Radiol)2016 MarMcCormick Gdoi: 10.1016/j.clon.2015.07.003
18523885Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1:psiBRCA1 recombination.Hum Mutat2002 AprBrown MA-
21681822No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study.Breast Cancer Res Treat2009 MayRebbeck TRdoi: 10.1007/s10549-008-0064-8
20353281Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer.Mol Carcinog2012 JunDeng Ydoi: 10.1002/mc.20813
17384678Population-based study of BRCA1/2 mutations: family history based criteria identify minority of mutation carriers.Neoplasma2010Mateju M-
19287951BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers.Oncogene2007 Sep 6Yuli C-
17244477A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells.Int J Oncol2009 AprXu J-
20727230Alternative splicing of breast cancer associated gene BRCA1 from breast cancer cell line.J Biochem Mol Biol2007 Jan 31Lixia M-
20038817BRCA1: linking HOX to breast cancer suppression.Breast Cancer Res2010Jin Kdoi: 10.1186/bcr2600
25675043Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.Cancer Biol Ther2009 DecNavaraj A-
23624935Feelings of Women With Strong Family Histories Who Subsequent to Their Breast Cancer Diagnosis Tested BRCA Positive.Int J Gynecol Cancer2015 MayJoseph Mdoi: 10.1097/IGC.0000000000000403.
20127252BRCA1 is a negative modulator of the PRC2 complex.EMBO J2013 May 29Wang Ldoi: 10.1038/emboj.2013.95
20135348Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer.J Cancer Res Clin Oncol2010 SepHu Hdoi: 10.1007/s00432-010-0795-x
25266802Screening for genomic rearrangements in BRCA1 and BRCA2 genes in Czech high-risk breast/ovarian cancer patients: high proportion of population specific alterations in BRCA1 gene.Breast Cancer Res Treat2010 NovTicha Idoi: 10.1007/s10549-010-0745-y
24131977The functional BRCA1 rs799917 genetic polymorphism is associated with gastric cancer risk in a Chinese Han population.Tumour Biol2015 JanWang Kdoi: 10.1007/s13277-014-2655-9
25486197Breast cancer risk in BRCA1 mutation carriers: insight from mouse models.Ann Oncol2013 NovBarcellos-Hoff MHdoi: 10.1093/annonc/mdt305.
23192404BRCA1 as a nicotinamide adenine dinucleotide (NAD)-dependent metabolic switch in ovarian cancer.Cell Cycle2014Li Ddoi: 10.4161/15384101.2015.942208.
25356972Evaluation of BRCA1 mutations in an unselected patient population with triple-negative breast cancer.Breast Cancer Res Treat2013 JanRummel Sdoi: 10.1007/s10549-012-2348-2
22614657BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study.Genet Med2015 JulZhen DBdoi: 10.1038/gim.2014.153
25724305Prevalence of BRCA mutations in an unselected population of triple-negative breast cancer.Cancer2012 Jun 1Hartman ARdoi: 10.1002/cncr.26576
19289372Splicing analysis of 14 BRCA1 missense variants classifies nine variants as pathogenic.Breast Cancer Res Treat2015 AprAhlborn LBdoi: 10.1007/s10549-015-3313-7
20437199XPG mRNA expression levels modulate prognosis in resected non-small-cell lung cancer in conjunction with BRCA1 and ERCC1 expression.Clin Lung Cancer2009 JanBartolucci Rdoi: 10.3816/CLC.2009.n.007.
18296025Identification of a novel BRCA1 nucleotide 4803delCC/c.4684delCC mutation and a nucleotide 249T>A/c.130T>A (p.Cys44Ser) mutation in two Greenlandic Inuit families: implications for genetic screening of Greenlandic Inuit families with high risk for breast and/or ovarian cancer.Breast Cancer Res Treat2010 NovHansen TVdoi: 10.1007/s10549-010-0909-9
23055523Nuclear export of BRCA1 occurs during early S phase and is calcium-dependent.Cell Signal2008 MayGlover-Collins Kdoi: 10.1016/j.cellsig.2008.01.007
17990525RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.J Biol Chem2012 Nov 23Muoz MCdoi: 10.1074/jbc.M112.410951
12362311[Novel BRCA1 gene mutations in breast cancer patients from St. Petersburg].Genetika2007 SepTikhomirova OS-
23975082[Analysis of mutation sites of BRCA1 gene in Chinese patients with breast cancer].Zhonghua Yi Xue Yi Chuan Xue Za Zhi2002 OctKe Y-
23810788Added value of family history in counseling about risk of BRCA1/2 mutation in early-onset epithelial ovarian cancer.Int J Gynecol Cancer2013 OctArts-de Jong Mdoi: 10.1097/IGC.0b013e3182a1cf71.
15785095The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial.Lancet Oncol2013 AugSandhu SKdoi: 10.1016/S1470-2045(13)70240-7
22856468BRCA1 gene expression in breast cancer in Kuwait: correlation with prognostic parameters.Med Princ Pract2005 Mar-AprAmirrad M-
24000781The BRCA1 S1715N mutation segregates with breast and ovarian cancer in an extended family pedigree.Clin Genet2013 MayCampbell Jdoi: 10.1111/j.1399-0004.2012.01933.x
24947112Risk of having BRCA1 mutation in high-risk women with triple-negative breast cancer: a meta-analysis.Clin Genet2014 JanTun NMdoi: 10.1111/cge.12270
16760289Improved overall survival after contralateral risk-reducing mastectomy in BRCA1/2 mutation carriers with a history of unilateral breast cancer: a prospective analysis.Int J Cancer2015 Feb 1Heemskerk-Gerritsen BAdoi: 10.1002/ijc.29032
24615043BRCA1 and BRCA2 genetic testing in Italian breast and/or ovarian cancer families: mutation spectrum and prevalence and analysis of mutation prediction models.Ann Oncol2006 JunCapalbo C-
20978112Specific BRCA1 gene variations amongst young Moroccan breast cancer patients.Genet Mol Res2014 Jan 31Tazzite Adoi: 10.4238/2014.January.31.5.
25485588Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer.Cancer Prev Res (Phila)2011 JanWong EMdoi: 10.1158/1940-6207.CAPR-10-0212
21598251A novel crosstalk between BRCA1 and poly (ADP-ribose) polymerase 1 in breast cancer.Cell Cycle2014Li Ddoi: 10.4161/15384101.2014.956507.
26014432Genetic polymorphisms in AURKA and BRCA1 are associated with breast cancer susceptibility in a Chinese Han population.J Pathol2011 DecRuan Ydoi: 10.1002/path.2902
24136669High prevalence of BRCA1 stop mutation c.4183C>T in the Tyrolean population: implications for genetic testing.Eur J Hum Genet2016 FebPlsler Ldoi: 10.1038/ejhg.2015.108
17333343The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation.Breast Cancer Res Treat2013 NovValentini Adoi: 10.1007/s10549-013-2729-1
25735359BRCA1 and BRCA2 status in a Central Sudanese series of breast cancer patients: interactions with genetic, ethnic and reproductive factors.Breast Cancer Res Treat2007 AprAwadelkarim KD-
22396490BRCA1 and BRCA2 common mutations in iranian breast cancer patients: a meta analysis.Asian Pac J Cancer Prev2015Forat-Yazdi M-
19763692Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors.Cancer Res2012 May 1Rottenberg Sdoi: 10.1158/0008-5472.CAN-11-4201
12019214Validation of the pedigree assessment tool (PAT) in families with BRCA1 and BRCA2 mutations.Ann Surg Oncol2010 JanTeller Pdoi: 10.1245/s10434-009-0697-9
21604195CGH-targeted linkage analysis reveals a possible BRCA1 modifier locus on chromosome 5q.Hum Mol Genet2002 May 15Nathanson KL-
20104584Factors associated with an individuals' decision to withdraw from genetic counseling for BRCA1 and BRCA2 genes mutations: are personality traits involved?Fam Cancer2011 SepCaruso Adoi: 10.1007/s10689-011-9454-x.
18060491Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.Hum Mutat2010 MarBorg Adoi: 10.1002/humu.21202.
17333342Identification of a novel BRCA1 large genomic rearrangement in a Spanish breast/ovarian cancer family.Breast Cancer Res Treat2008 NovPalanca Suela S-
21156238Prevalence of BRCA1 and BRCA2 genomic rearrangements in a cohort of consecutive Italian breast and/or ovarian cancer families.Breast Cancer Res Treat2007 DecBuffone A-
17063270Germline mutations of BRCA1 and BRCA2 genes in Turkish breast, ovarian, and prostate cancer patients.Cancer Genet Cytogenet2010 DecManguolu Edoi: 10.1016/j.cancergencyto.2010.07.125.
19029836Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Brazil.Breast Cancer Res Treat2007 JulGomes MC-
15066328Absence of germline BRCA1 mutations in familial pancreatic cancer patients.Cancer Biol Ther2009 JanAxilbund JE-
23562522BRCA1 IVS2-2delA: a deleterious mutation in a family of Asian descent.Cancer Genet Cytogenet2004 Apr 15Martin ES-
19454503Methylation analysis of BRCA1, RASSF1, GSTP1 and EPHB2 promoters in prostate biopsies according to different degrees of malignancy.In Vivo2009 May-JunRabiau N-
25047471Comparison of nodal metastasis between BRCA mutation carriers and non-BRCA mutation carriers with breast cancer.Ann Surg Oncol2014 OctNoori SFdoi: 10.1245/s10434-014-3904-2
22776961Germline BRCA1 and BRCA2 mutations in ovarian cancer: utility of a histology-based referral strategy.Obstet Gynecol2012 AugSchrader KAdoi: 10.1097/AOG.0b013e31825f3576.
19269198Coexpression of the mutated BRCA1 mRNA and p53 mRNA and its association in Chinese prostate cancer.Urol Oncol2011 Mar-AprDing GFdoi: 10.1016/j.urolonc.2009.01.002
26106036Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.Nat Commun2015 Jun 24Sedic Mdoi: 10.1038/ncomms8505.
25394901MiR-218 regulates cisplatin chemosensitivity in breast cancer by targeting BRCA1.Tumour Biol2015 MarHe Xdoi: 10.1007/s13277-014-2814-z
20862552BRCA1 mutations and colorectal cancer in Poland.Fam Cancer2010 DecSuchy Jdoi: 10.1007/s10689-010-9378-x.
26483394Prevalence of Pathogenic Mutations in Cancer Predisposition Genes among Pancreatic Cancer Patients.Cancer Epidemiol Biomarkers Prev2016 JanHu Cdoi: 10.1158/1055-9965.EPI-15-0455
20452659Risk factors for carcinoma of the fallopian tube in women with and without a germline BRCA mutation.Gynecol Oncol2010 Aug 1Vicus Ddoi: 10.1016/j.ygyno.2010.03.009
24217135The influence of BRCA1/BRCA2 mutations on toxicity related to chemotherapy and radiotherapy in early breast cancer patients.Oncology2013Huszno Jdoi: 10.1159/000354834
20972632Breast cancer surgery trend changes since the introduction of BRCA1/2 mutation screening: a retrospective cohort analysis of 158 mutation carriers treated at a single institution.Ann Surg Oncol2011 MarMislowsky Adoi: 10.1245/s10434-010-1381-9
21119368BRCA germline mutations in women with uterine serous carcinoma--still a debate.Int J Gynecol Cancer2010 DecLavie Odoi: 10.1111/IGC.0b013e3181cd242f.
17061047Prognosis of early-onset breast cancer based on BRCA1/2 mutation status in a French population-based cohort and review.Breast Cancer Res Treat2007 JanBonadona V-
18710587Variation in breast cancer risk in BRCA1 and BRCA2 mutation carriers.Breast Cancer Res2008Rebbeck TRdoi: 10.1186/bcr2115
22535016Double heterozygosity for mutations in BRCA1 and BRCA2 in German breast cancer patients: implications on test strategies and clinical management.Breast Cancer Res Treat2012 AugHeidemann Sdoi: 10.1007/s10549-012-2050-4
17018160Contribution of germline BRCA1 and BRCA2 sequence alterations to breast cancer in Northern India.BMC Med Genet2006 Oct 4Saxena S-
25816289Worse breast cancer prognosis of BRCA1/BRCA2 mutation carriers: what's the evidence? A systematic review with meta-analysis.PLoS One2015 Mar 27van den Broek AJdoi: 10.1371/journal.pone.0120189
19549808Oral contraceptive use and BRCA penetrance: a case-only study.Cancer Epidemiol Biomarkers Prev2009 JulPasanisi Pdoi: 10.1158/1055-9965.EPI-09-0024
17262179Differences in the frequency and distribution of BRCA1 and BRCA2 mutations in breast/ovarian cancer cases from the Basque country with respect to the Spanish population: implications for genetic counselling.Breast Cancer Res Treat2007 DecBeristain E-
24145348Oral contraceptives and risk of ovarian cancer and breast cancer among high-risk women: a systematic review and meta-analysis.J Clin Oncol2013 Nov 20Moorman PGdoi: 10.1200/JCO.2013.48.9021
25961039Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling.Biomed Res Int2015Li Ddoi: 10.1155/2015/746970
25251729Impact of a paternal origin of germline BRCA1/2 mutations on the age at breast and ovarian cancer diagnosis in a Southern Swedish cohort.Genes Chromosomes Cancer2015 JanEllberg Cdoi: 10.1002/gcc.22217
19223505Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner.Clin Cancer Res2009 Mar 1Schayek Hdoi: 10.1158/1078-0432.CCR-08-1440
25682074Prevalence of BRCA1 and BRCA2 germline mutations in patients with triple-negative breast cancer.Breast Cancer Res Treat2015 FebWong-Brown MWdoi: 10.1007/s10549-015-3293-7
23326344BRCA1 mRNA expression as a predictive and prognostic marker in advanced esophageal squamous cell carcinoma treated with cisplatin- or docetaxel-based chemotherapy/chemoradiotherapy.PLoS One2013Gao Ydoi: 10.1371/journal.pone.0052589
24529552BRCA1/2 mutation carriers are potentially at higher cardiovascular risk.Crit Rev Oncol Hematol2014 AugArts-de Jong Mdoi: 10.1016/j.critrevonc.2014.01.008
15803127Promoter usage of BRCA1-IRIS.Nat Cell Biol2005 AprElshamy WM-
23175448BRCA1 germ-line mutations and tumor characteristics in eastern Chinese women with familial breast cancer.Anat Rec (Hoboken)2013 FebCao Wdoi: 10.1002/ar.22628
24010542High prevalence of BRCA1 founder mutations in Greek breast/ovarian families.Clin Genet2014 JanKonstantopoulou Idoi: 10.1111/cge.12274
16769276The prevalence of germline BRCA1 and BRCA2 mutations in young women with breast cancer undergoing breast-conservation therapy.Am J Surg2006 JulGolshan M-
12582017BRCA1 wild-type allele modifies risk of ovarian cancer in carriers of BRCA1 germ-line mutations.Cancer Epidemiol Biomarkers Prev2003 FebGinolhac SM-
12114493Detection of large rearrangements of exons 13 and 22 in the BRCA1 gene in German families.J Med Genet2002 JulHofmann W-
23941904The different impact of BRCA mutations on the survival of epithelial ovarian cancer patients: a retrospective single-center experience.Oncology2013Lorusso Ddoi: 10.1159/000353786
21499684Cancer risk in Jewish BRCA1 and BRCA2 mutation carriers: effects of oral contraceptive use and parental origin of mutation.Breast Cancer Res Treat2011 SepBernholtz Sdoi: 10.1007/s10549-011-1509-z
19877382Breast cancer immunohistochemical features in young women with BRCA 1/2 mutations.Exp Oncol2009 SepZakhartseva LM-
12100744Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer.Breast Cancer Res2002Yassaee VR-
24567435Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation.J Clin Oncol2014 May 20Finch APdoi: 10.1200/JCO.2013.53.2820
19197335Genetic sequence variations of BRCA1-interacting genes AURKA, BAP1, BARD1 and DHX9 in French Canadian families with high risk of breast cancer.J Hum Genet2009 MarGu??nard Fdoi: 10.1038/jhg.2009.6
23984822Analysis of BRCA1 and mtDNA haplotypes and mtDNA polymorphism in familial breast cancer.Mitochondrial DNA2015 AprGuti??rrez Povedano Cdoi: 10.3109/19401736.2013.825773
27083178Frequency of germline DNA genetic findings in an unselected prospective cohort of triple-negative breast cancer patients participating in a platinum-based neoadjuvant chemotherapy trial.Breast Cancer Res Treat2016 AprGonz??lez-Rivera Mdoi: 10.1007/s10549-016-3792-1
18642075Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and p53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers.Breast Cancer Res Treat2009 JulKontorovich Tdoi: 10.1007/s10549-008-0121-3
19522853BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer.Cancer Sci2009 SepChen Ydoi: 10.1111/j.1349-7006.2009.01225.x
12242698Highlight: BRCA1 and BRCA2 proteins in breast cancer.Microsc Res Tech2002 Oct 1Daniel DC-
18397521Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism.BMC Cancer2008 Apr 8Jakubowska Adoi: 10.1186/1471-2407-8-90.
16826315BRCA1 and BRCA2 germline mutational spectrum and evidence for genetic anticipation in Portuguese breast/ovarian cancer families.Fam Cancer2006Peixoto A-
19374245[Evaluation of stomatognathic system in BRCA1 gene mutation carriers before and after prophylactic adnexectomy--part II: evaluation of stomatognathic system in BRCA1 gene mutation carriers after prophylactic adnexectomy].Ann Acad Med Stetin2008Chruciel-Nogalska M-
22516946Germline BRCA1 mutations increase prostate cancer risk.Br J Cancer2012 May 8Leongamornlert Ddoi: 10.1038/bjc.2012.146.
26822887BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer.Cell Cycle2016Sedic Mdoi: 10.1080/15384101.2016.1141841.
14550570BRCA1 interacts with FHL2 and enhances FHL2 transactivation function.FEBS Lett2003 Oct 9Yan J-
25048467Molecular features of the basal-like breast cancer subtype based on BRCA1 mutation status.Breast Cancer Res Treat2014 AugPrat Adoi: 10.1007/s10549-014-3056-x
27165220Mutation Spectra of BRCA Genes in Iranian Women with Early Onset Breast Cancer - 15 Years Experience.Asian Pac J Cancer Prev2016Yassaee VR-
16222692The impact of receiving genetic test results on general and cancer-specific psychologic distress among members of an African-American kindred with a BRCA1 mutation.Cancer2005 Dec 1Kinney AY-
14612409BRCA1 inhibition of telomerase activity in cultured cells.Mol Cell Biol2003 DecXiong J-
20406939Increased incidence of visceral metastases in scottish patients with BRCA1/2-defective ovarian cancer: an extension of the ovarian BRCAness phenotype.J Clin Oncol2010 May 20Gourley Cdoi: 10.1200/JCO.2009.25.1082
27039761BRCA1 Gene Mutations and Influence of Chemotherapy on Autophagy and Apoptotic Mechanisms in Egyptian Breast Cancer Patients.Asian Pac J Cancer Prev2016Abdel-Mohsen MA-
21356067Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals.Breast Cancer Res2011 Feb 28Kuusisto KMdoi: 10.1186/bcr2832.
19440381Misbehaviour of XIST RNA in breast cancer cells.PLoS One2009Sirchia SMdoi: 10.1371/journal.pone.0005559
25850293[Genotyping of BRCA1, BRCA2 and CHEK2 germline mutations in Russian breast cancer patients using diagnostic biochips].Mol Biol (Mosk)2014 Mar-AprNasedkina TV-
18594935BRCA1 185delAG truncation protein, BRAt, amplifies caspase-mediated apoptosis in ovarian cells.In Vitro Cell Dev Biol Anim2008 Sep-OctO'Donnell JDdoi: 10.1007/s11626-008-9122-0
19190154Reproductive and hormonal factors, and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: results from the International BRCA1/2 Carrier Cohort Study.Cancer Epidemiol Biomarkers Prev2009 FebAntoniou ACdoi: 10.1158/1055-9965.EPI-08-0546
22739995Recurrent BRCA1 and BRCA2 mutations in breast cancer patients of African ancestry.Breast Cancer Res Treat2012 JulZhang Jdoi: 10.1007/s10549-012-2136-z
21869484Identification of novel intronic BRCA1 variants of uncertain significance in a Thai hereditary breast cancer family.J Genet2011 AugRatanaphan A-
21318380Screening of 1331 Danish breast and/or ovarian cancer families identified 40 novel BRCA1 and BRCA2 mutations.Fam Cancer2011 JunHansen TVdoi: 10.1007/s10689-011-9422-5.
27221844Screening for Del 185 AG and 4627C>A BRCA1 Mutations in Breast Cancer Patients from Lahore, Pakistan.Asian Pac J Cancer Prev2016Aziz F-
22212556The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers.Breast Cancer Res Treat2012 AprLaitman Ydoi: 10.1007/s10549-011-1938-8
14559807BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis.Cancer Res2003 Oct 1Quinn JE-
27465548DNA repair pathways to regulate response to chemoradiotherapy in patients with locally advanced head and neck cancer.Tumour Biol2016 OctCirauqui B-
25228385miR-638 mediated regulation of BRCA1 affects DNA repair and sensitivity to UV and cisplatin in triple-negative breast cancer.Breast Cancer Res2014 Sep 17Tan Xdoi: 10.1186/s13058-014-0435-5.
23458327The spectrum of BRCA1 and BRCA2 mutations in breast cancer patients in the Bahamas.Clin Genet2014 JanAkbari MRdoi: 10.1111/cge.12132
18204050Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk.Hum Mol Genet2008 May 1Chen Xdoi: 10.1093/hmg/ddn022
22972572Evidence that BRCA1- or BRCA2-associated cancers are not inevitable.Mol Med2012 Dec 6Levin Bdoi: 10.2119/molmed.2012.00280.
18513387Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a Clinical Cancer Genetics service setting: risks of breast/ovarian cancer quoted should reflect the cancer burden in the family.BMC Cancer2008 May 30Evans DGdoi: 10.1186/1471-2407-8-155.
21653198Prevalence of BRCA1 and BRCA2 mutations in triple negative breast cancer.J Med Genet2011 AugEvans DGdoi: 10.1136/jmedgenet-2011-100006
16533773Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer.Clin Cancer Res2006 Mar 1Grabsch H-
15073127Pathology of ovarian cancers in BRCA1 and BRCA2 carriers.Clin Cancer Res2004 Apr 1Lakhani SR-
19073515BRCA1: a new genomic marker for non-small-cell lung cancer.Clin Lung Cancer2008 NovReguart Ndoi: 10.3816/CLC.2008.n.048.
23666017Cost-effectiveness of BRCA1 and BRCA2 mutation testing to target PARP inhibitor use in platinum-sensitive recurrent ovarian cancer.Int J Gynecol Cancer2013 JunSecord AAdoi: 10.1097/IGC.0b013e31829527bd.
17661172Identification of rare complete BRCA1 gene deletion using a combination of SNP haplotype analysis, MLPA and array-CGH techniques.Breast Cancer Res Treat2008 JunKonecny M-
25605143Clinicopathological significance of BRCA1 promoter hypermethylation in Thai breast cancer patients.Asian Pac J Cancer Prev2014Saelee P-
20413709A BRCA1 promoter variant (rs11655505) and breast cancer risk.J Med Genet2010 AprVerderio Pdoi: 10.1136/jmg.2009.073544.
20221693Absence of genomic BRCA1 and BRCA2 rearrangements in Ashkenazi breast and ovarian cancer families.Breast Cancer Res Treat2010 SepStadler ZKdoi: 10.1007/s10549-010-0818-y
26997744Contribution of BRCA1 and BRCA2 Germline Mutations to Early Algerian Breast Cancer.Dis Markers2016Henouda Sdoi: 10.1155/2016/7869095
19841329Preventing future cancers by testing women with ovarian cancer for BRCA mutations.J Clin Oncol2010 Feb 1Kwon JSdoi: 10.1200/JCO.2008.21.4684
21990299Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer.JAMA2011 Oct 12Yang Ddoi: 10.1001/jama.2011.1456.
18819001BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy.Breast Cancer Res Treat2009 AugOttini Ldoi: 10.1007/s10549-008-0194-z
23957571Acute skin toxicity in Korean breast cancer patients carrying BRCA mutations.Int J Radiat Biol2014 JanPark Hdoi: 10.3109/09553002.2013.835504
18940477Ovarian cancer patient with germline mutations in both BRCA1 and NBN genes.Cancer Genet Cytogenet2008 Oct 15Porhanova NVdoi: 10.1016/j.cancergencyto.2008.06.012.
25788227Cancer risks in Jewish male BRCA1 and BRCA2 mutation carriers.Breast Cancer Res Treat2015 AprLaitman Ydoi: 10.1007/s10549-015-3340-4
12442275BRCA1 and BRCA2 mutation analysis of early-onset and familial breast cancer cases in Mexico.Hum Mutat2002 DecRuiz-Flores P-
20470789Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients.Life Sci2010 Jul 17Sharma Gdoi: 10.1016/j.lfs.2010.05.001
12815604The analysis of BRCA1 mutations in eastern Chinese patients with early onset breast cancer and affected relatives.Hum Mutat2003 JulHu Z-
21343941Morphological predictors of BRCA1 germline mutations in young women with breast cancer.Br J Cancer2011 Mar 15Southey MCdoi: 10.1038/bjc.2011.41
15733268Identification of germline BRCA1 and BRCA2 genetic alterations in Greek breast cancer moderate-risk and low-risk individuals--correlation with clinicopathological data.Clin Genet2005 AprKataki A-
23975317Prevalence of BRCA mutations among women with triple-negative breast cancer (TNBC) in a genetic counseling cohort.Ann Surg Oncol2013 OctGreenup Rdoi: 10.1245/s10434-013-3205-1
25398451Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer.Clin Cancer Res2015 Feb 1Candido-dos-Reis FJdoi: 10.1158/1078-0432.CCR-14-2497
24728189The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population.Hum Mol Genet2014 Sep 1Song Hdoi: 10.1093/hmg/ddu172
18095152Breast cancer risk and the BRCA1 interacting protein CTIP.Breast Cancer Res Treat2008 NovGorringe KL-
25047474Implementing a screening tool for identifying patients at risk for hereditary breast and ovarian cancer: a statewide initiative.Ann Surg Oncol2014 OctBrannon Traxler Ldoi: 10.1245/s10434-014-3921-1
25821000Risk-reducing mastectomy for BRCA gene mutation carriers.Ann Surg Oncol2015 SepEuhus DMdoi: 10.1245/s10434-015-4537-9
19140568Is there any relationship between BRCA1 gene mutation and pancreatic cancer development?Pol Arch Med Wewn2008 NovLawniczak M-
20134318Prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers: very low risk for subsequent breast cancer.Ann Surg2010 MarKaas Rdoi: 10.1097/SLA.0b013e3181c3c36d.
26219241Multigene Panel Testing Detects Equal Rates of Pathogenic BRCA1/2 Mutations and has a Higher Diagnostic Yield Compared to Limited BRCA1/2 Analysis Alone in Patients at Risk for Hereditary Breast Cancer.Ann Surg Oncol2015 OctKapoor NSdoi: 10.1245/s10434-015-4754-2
25092866BRCA1 pathway function in basal-like breast cancer cells.Mol Cell Biol2014 OctHill SJdoi: 10.1128/MCB.01646-13
19885732Breast cancer risks in individuals testing negative for a known family mutation in BRCA1 or BRCA2.Breast Cancer Res Treat2010 JanDomchek SMdoi: 10.1007/s10549-009-0611-y.
24026861BRCA1 promoter methylation is a marker of better response to anthracycline-based therapy in sporadic TNBC.Breast Cancer Res Treat2013 SepIgnatov Tdoi: 10.1007/s10549-013-2693-9
21191178Rare BRCA1 haplotypes including 3'UTR SNPs associated with breast cancer risk.Cell Cycle2011 Jan 1Pelletier C-
12920090BRCA1 and BRCA2 mutations have no major role in predisposition to prostate cancer in Finland.J Med Genet2003 AugIkonen T-
25716084The prevalence of BRCA1 and BRCA2 mutations among young Mexican women with triple-negative breast cancer.Breast Cancer Res Treat2015 AprVillarreal-Garza Cdoi: 10.1007/s10549-015-3312-8
22274685Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer.JAMA2012 Jan 25Bolton KLdoi: 10.1001/jama.2012.20.
26740498Poor response to platinum-based chemotherapy is associated with KRAS mutation and concomitant low expression of BRAC1 and TYMS in NSCLC.J Int Med Res2016 FebZhou Hdoi: 10.1177/0300060515607383
22426855BRCA1--conductor of the breast stem cell orchestra: the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast cancer.Stem Cell Rev2012 SepBuckley NEdoi: 10.1007/s12015-012-9354-y.
16996204BRCA1 and TP53 mutation spectrum of breast carcinoma in an ethnic population of Kashmir, an emerging high-risk area.Cancer Lett2007 Apr 18Eachkoti R-
24698998DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers.PLoS Genet2014 Apr 3Osorio Adoi: 10.1371/journal.pgen.1004256
21404118A novel de novo BRCA1 mutation in a Chinese woman with early onset breast cancer.Fam Cancer2011 JunKwong Adoi: 10.1007/s10689-011-9429-y.
16261400Incidence of BRCA1 and BRCA2 mutations in 54 Chilean families with breast/ovarian cancer, genotype-phenotype correlations.Breast Cancer Res Treat2006 JanGallardo M-
20388772Immunohistochemical expression of BRCA1 and lethal prostate cancer.Cancer Res2010 Apr 15Fiorentino Mdoi: 10.1158/0008-5472.CAN-09-4100
16912212Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years.Cancer Res2006 Aug 15Malone KE-
20579331Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection.J Exp Clin Cancer Res2010 Jun 25Ibrahim SSdoi: 10.1186/1756-9966-29-82.
21920589BRCA1 is both a prognostic and predictive biomarker of response to chemotherapy in sporadic epithelial ovarian cancer.Gynecol Oncol2011 DecCarser JEdoi: 10.1016/j.ygyno.2011.08.017
21918854BRCA1 and BRCA2 germline mutations in 85 Iranian breast cancer patients.Fam Cancer2012 MarKeshavarzi Fdoi: 10.1007/s10689-011-9477-3.
17585057Common variation in the BRCA1 gene and prostate cancer risk.Cancer Epidemiol Biomarkers Prev2007 JulDouglas JA-
12442274BRCA1 and BRCA2 sequence variants in Chinese breast cancer families.Hum Mutat2002 DecZhi X-
17420720Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.Oncogene2007 Sep 13Jeng YM-
20418484Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers.Hum Mol Genet2010 Jul 15Wang Xdoi: 10.1093/hmg/ddq174
21603983Cancer worry among Norwegian male BRCA1/2 mutation carriers.Fam Cancer2011 SepStrmsvik Ndoi: 10.1007/s10689-011-9456-8.
25339023Evaluation of genetic variations in miRNA-binding sites of BRCA1 and BRCA2 genes as risk factors for the development of early-onset and/or familial breast cancer.Asian Pac J Cancer Prev2014Erturk E-
17972172Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years.Breast Cancer Res Treat2008 MayBreast Cancer Family Registry-
25082516Mammography screening and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a prospective study.Breast Cancer Res Treat2014 AugGiannakeas Vdoi: 10.1007/s10549-014-3063-y
15365993BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer.Hum Mutat2004 OctSeo JH-
17661168BRCA1/BRCA2 rearrangements and CHEK2 common mutations are infrequent in Italian male breast cancer cases.Breast Cancer Res Treat2008 JulFalchetti M-
16905680Evaluation of BRCA1 and BRCA2 mutation prevalence, risk prediction models and a multistep testing approach in French-Canadian families with high risk of breast and ovarian cancer.J Med Genet2007 FebSimard J-
23803067mRNA expression and clinical significance of ERCC1, BRCA1, RRM1, TYMS and TUBB3 in postoperative patients with non-small cell lung cancer.Asian Pac J Cancer Prev2013Han Y-
22072393Gene-gene interactions in breast cancer susceptibility.Hum Mol Genet2012 Feb 15Turnbull Cdoi: 10.1093/hmg/ddr525
23447579TNRC9 downregulates BRCA1 expression and promotes breast cancer aggressiveness.Cancer Res2013 May 1Shan Jdoi: 10.1158/0008-5472.CAN-12-4313
23992000Identification of germline BRCA1 mutations among breast cancer families in Northeastern Iran.Asian Pac J Cancer Prev2013Kooshyar MM-
22032289BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.Biochem J2012 Feb 1Dohrn Ldoi: 10.1042/BJ20110314.
25792249Fertility treatments and invasive epithelial ovarian cancer risk in Jewish Israeli BRCA1 or BRCA2 mutation carriers.Fertil Steril2015 MayPerri Tdoi: 10.1016/j.fertnstert.2015.02.011
18844490New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia.Clin Chem Lab Med2008Cvok MLdoi: 10.1515/CCLM.2008.307.
26239694Risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a 30-year semi-prospective analysis.Fam Cancer2015 DecBasu NNdoi: 10.1007/s10689-015-9825-9.
17257844BRCA mutations, molecular markers, and clinical variables in early-onset breast cancer: a population-based study.Breast2007 JunMusolino A-
19865540Functional analysis of familial Asp67Glu and Thr1051Ser BRCA1 mutations in breast/ovarian carcinogenesis.Int J Mol Sci2009 Sep 24Pongsavee Mdoi: 10.3390/ijms10094187.
19669600Low contribution of BRCA1/2 genomic rearrangement to high-risk breast cancer in the Korean population.Fam Cancer2009Seong MWdoi: 10.1007/s10689-009-9279-z
18950515Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers.BMC Cancer2008 Oct 25Toyama Tdoi: 10.1186/1471-2407-8-309.
26299336How medical choices influence quality of life of women carrying a BRCA mutation.Crit Rev Oncol Hematol2015 DecHarmsen MGdoi: 10.1016/j.critrevonc.2015.07.010
22889855BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk.J Med Genet2012 AugSpurdle AB-
23958087Analysis of several BRCA1 and BRCA2 mutations in a hospital-based series of unselected breast cancer cases.Chirurgia (Bucur)2013 Jul-AugBurco T-
15983021Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women.J Med Genet2006 FebHaffty BG-
16724273 among women under 40 years of age diagnosed with breast cancer and carrying a BRCA1 or BRCA2 mutation.J Genet Couns2006 JunKenen R-
12112655BRCA1 and BRCA2 mutations in Turkish familial and non-familial ovarian cancer patients: a high incidence of mutations in non-familial cases.Hum Mutat2002 JulYazici H-
22691290Li-Fraumeni-like syndrome associated with a large BRCA1 intragenic deletion.BMC Cancer2012 Jun 12Silva AGdoi: 10.1186/1471-2407-12-237.
17051349Risks of cancer due to a single BRCA1 mutation in an extended Utah kindred.Fam Cancer2007Vogl FD-
12698198BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells.Br J Cancer2003 Apr 22Tassone P-
21666281Mutations in the BRCT binding site of BRCA1 result in hyper-recombination.Aging (Albany NY)2011 MayDever SM-
12237282Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program.J Natl Cancer Inst2002 Sep 18Brose MS-
22736296Incorporating information regarding preimplantation genetic diagnosis into discussions concerning testing and risk management for BRCA1/2 mutations: a qualitative study of patient preferences.Cancer2012 Dec 15Hurley Kdoi: 10.1002/cncr.27695
20451485Identification of novel large genomic rearrangements at the BRCA1 locus in Malaysian women with breast cancer.Cancer Epidemiol2010 AugSharifah NAdoi: 10.1016/j.canep.2010.04.010
19887602Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.Cancer Res2009 Nov 15Ueki Tdoi: 10.1158/0008-5472.CAN-09-1809
23767878BRCA1/2 mutation screening in high-risk breast/ovarian cancer families and sporadic cancer patient surveilling for hidden high-risk families.BMC Med Genet2013 Jun 14Berzina Ddoi: 10.1186/1471-2350-14-61.
17850627Screening for BRCA1 and BRCA2 mutations in Eastern Finnish breast/ovarian cancer families.Clin Genet2007 OctHartikainen JM-
19729830Role of BRCA1, HSD17B1 and HSD17B2 methylation in breast cancer tissue.Cancer Biomark2009Bhavani Vdoi: 10.3233/CBM-2009-0105.
19858402Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers.J Clin Oncol2009 Dec 10Graeser MKdoi: 10.1200/JCO.2008.19.9430
22110403Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.PLoS Biol2011 NovMaxwell CAdoi: 10.1371/journal.pbio.1001199
17453335Greek BRCA1 and BRCA2 mutation spectrum: two BRCA1 mutations account for half the carriers found among high-risk breast/ovarian cancer patients.Breast Cancer Res Treat2008 FebKonstantopoulou I-
25066186Identification of a recurrent BRCA1 exon 21-22 genomic rearrangement in Malay breast cancer patients.Clin Genet2015 AprHasmad HNdoi: 10.1111/cge.12451
23278966cDNA analysis of the BRCA1 unclassified variant c.5194-12G>A.Clin Genet2013 NovWong-Brown MWdoi: 10.1111/cge.12052
27272846Thyroid Hormones and Vitamin D in Patients with Breast Cancer with Mutations in BRCA1 or BRCA2 Genes.Anticancer Res2016 JunKolben T-
24312913A comprehensive focus on global spectrum of BRCA1 and BRCA2 mutations in breast cancer.Biomed Res Int2013Karami Fdoi: 10.1155/2013/928562
20338046DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.Mol Cancer2010 Mar 25Dejeux Edoi: 10.1186/1476-4598-9-68.
22946335[Prevalence of mutations BRCA1 5382insC, and CHEK2 1100delC in the population of Siberian region].Genetika2012 JunChasovnikova OB-
26195437Epigenetic Inactivation of BRCA1 Through Promoter Hypermethylation and Its Clinical Importance in Triple-Negative Breast Cancer.Clin Breast Cancer2015 DecYamashita Ndoi: 10.1016/j.clbc.2015.06.009
24443257ERCC1 and BRCA1 mRNA expressions are associated with clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy.Tumour Biol2014 MayQin Xdoi: 10.1007/s13277-014-1615-8
26083025Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers.PLoS One2015 Jun 17Domagala Pdoi: 10.1371/journal.pone.0130393
12668603Roles of BRCA1 in DNA damage repair: a link between development and cancer.Hum Mol Genet2003 Apr 1Deng CX-
12442273BRCA1 and BRCA2 in Indian breast cancer patients.Hum Mutat2002 DecSaxena S-
18813953Association of loss of BRCA1 expression with centrosome aberration in human breast cancer.J Cancer Res Clin Oncol2009 MarShimomura Adoi: 10.1007/s00432-008-0472-5
20135344Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer.Breast Cancer Res Treat2010 SepReding KWdoi: 10.1007/s10549-010-0769-3
26637364High XIST and Low 53BP1 Expression Predict Poor Outcome after High-Dose Alkylating Chemotherapy in Patients with a BRCA1-like Breast Cancer.Mol Cancer Ther2016 JanSchouten PCdoi: 10.1158/1535-7163.MCT-15-0470
26902145BRCA1 inhibits AR-mediated proliferation of breast cancer cells through the activation of SIRT1.Sci Rep2016 Feb 23Zhang Wdoi: 10.1038/srep22034.
17063264Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks.Breast Cancer Res Treat2007 SepJakubowska A-
22093627[EGFR gene copy number, ERCC1 and BRCA1 protein expression and their relationship in non-small cell lung cancer].Zhonghua Zhong Liu Za Zhi2011 JulDeng QH-
17080309High proportion of BRCA1/2 founder mutations in Hispanic breast/ovarian cancer families from Colombia.Breast Cancer Res Treat2007 JunTorres D-
22685544BRCA1 regulates follistatin function in ovarian cancer and human ovarian surface epithelial cells.PLoS One2012Karve TMdoi: 10.1371/journal.pone.0037697
22476849Rare germline large rearrangements in the BRCA1/2 genes and eight candidate genes in 472 patients with breast cancer predisposition.Breast Cancer Res Treat2012 JunRouleau Edoi: 10.1007/s10549-012-2009-5
22970155Identification of BRCA1/2 founder mutations in Southern Chinese breast cancer patients using gene sequencing and high resolution DNA melting analysis.PLoS One2012Kwong Adoi: 10.1371/journal.pone.0043994
24140203The sex hormone system in carriers of BRCA1/2 mutations: a case-control study.Lancet Oncol2013 NovWidschwendter Mdoi: 10.1016/S1470-2045(13)70448-0
22262156Anthropometric measures and risk of ovarian cancer among BRCA1 and BRCA2 mutation carriers.Obesity (Silver Spring)2012 JunMcGee Jdoi: 10.1038/oby.2011.394
19383352Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.Mol Oncol2008 DecBartkova Jdoi: 10.1016/j.molonc.2008.09.007
26852015Novel germline mutations and unclassified variants of BRCA1 and BRCA2 genes in Chinese women with familial breast/ovarian cancer.BMC Cancer2016 Feb 6Cao WMdoi: 10.1186/s12885-016-2107-6.
24297685Detection of a novel mutation in exon 20 of the BRCA1 gene.Cell Mol Biol Lett2013 DecChakraborty Adoi: 10.2478/s11658-013-0110-3
17645508Prolonged survival among women with BRCA germline mutations and advanced endometrial cancer: a case series.Int J Gynecol Cancer2008 May-JunKwon JS-
23320992Early onset breast cancer in a registry-based sample of African-american women: BRCA mutation prevalence, and other personal and system-level clinical characteristics.Breast J2013 Mar-AprPal Tdoi: 10.1111/tbj.12083
17599361Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients.Life Sci2007 Jul 4Mirza S-
20730487Body weight and risk of breast cancer in BRCA1/2 mutation carriers.Breast Cancer Res Treat2011 FebManders Pdoi: 10.1007/s10549-010-1120-8
27039803BRCA1 Gene Mutation Screening for the Hereditary Breast and/or Ovarian Cancer Syndrome in Breast Cancer Cases: a First High Resolution DNA Melting Analysis in Indonesia.Asian Pac J Cancer Prev2016Mundhofir FE-
16773440Premature menopause in patients with BRCA1 gene mutation.Breast Cancer Res Treat2006 NovRzepka-G??rska I-
12181777Contribution of BRCA1 and BRCA2 mutations to breast and ovarian cancer in Pakistan.Am J Hum Genet2002 SepLiede A-
25257187Salivary gland cancer in BRCA-positive families: a retrospective review.JAMA Otolaryngol Head Neck Surg2014 DecShen TKdoi: 10.1001/jamaoto.2014.1998.
27244682BRCA1 and BRCA2 Testing Among Young Breast Cancer Survivors.JAMA Oncol2016 May 1Kehl KLdoi: 10.1001/jamaoncol.2016.0976.
16830385Genetic instability of BRCA1 gene at locus D17S855 is related to clinicopathological behaviors of gastric cancer from Chinese population.World J Gastroenterol2006 Jul 14Chen XR-
22923021Novel BRCA1 and BRCA2 pathogenic mutations in Slovene hereditary breast and ovarian cancer families.Int J Oncol2012 NovNovakovi Sdoi: 10.3892/ijo.2012.1595
23462720BRCA1 expression and improved survival in ovarian cancer patients treated with intraperitoneal cisplatin and paclitaxel: a Gynecologic Oncology Group Study.Br J Cancer2013 Apr 2Lesnock JLdoi: 10.1038/bjc.2013.70
24306927Etiology of familial breast cancer with undetected BRCA1 and BRCA2 mutations: clinical implications.Cell Oncol (Dordr)2014 FebYiannakopoulou Edoi: 10.1007/s13402-013-0158-0
21391735BRCA1/2 status and clinicopathologic characteristics of patients with double primary breast and ovarian cancer.Neoplasma2011Cvelbar M-
19200354A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history.Breast Cancer Res2009G??mez Garc??a EBdoi: 10.1186/bcr2223
16949048Identification of BRCA1 and BRCA2 mutations from Korean breast cancer patients using denaturing HPLC.Biochem Biophys Res Commun2006 Oct 20Kim BY-
23787073Genetic polymorphisms in AURKA, BRCA1, CCNE1 and CDK2 are associated with ovarian cancer susceptibility among Chinese Han women.Cancer Epidemiol2013 OctZheng Ldoi: 10.1016/j.canep.2013.04.018
23405268Methylation of BRCA1 promoter region is associated with unfavorable prognosis in women with early-stage breast cancer.PLoS One2013Hsu NCdoi: 10.1371/journal.pone.0056256
22576580Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study.Cancer Causes Control2012 JulKotsopoulos Jdoi: 10.1007/s10552-012-9975-0
22009639Predictive factors for BRCA1/BRCA2 mutations in women with ductal carcinoma in situ.Cancer2012 Mar 15Bayraktar Sdoi: 10.1002/cncr.26428
17220212Integrin beta3 Leu33Pro polymorphism increases BRCA1-associated ovarian cancer risk.J Med Genet2007 JunJakubowska A-
12427738Structural consequences of a cancer-causing BRCA1-BRCT missense mutation.J Biol Chem2003 Jan 24Williams RS-
17902052G1738R is a BRCA1 founder mutation in Greek breast/ovarian cancer patients: evaluation of its pathogenicity and inferences on its genealogical history.Breast Cancer Res Treat2008 JulAnagnostopoulos T-
22586318Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers.Cancer Discov2011 JunBalmaa Jdoi: 10.1158/2159-8274.CD-11-0048
19360465BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms.Breast Cancer Res Treat2010 JanJakubowska Adoi: 10.1007/s10549-009-0390-5
19364506BRCA1 down-regulates cellular levels of reactive oxygen species.FEBS Lett2009 May 6Saha Tdoi: 10.1016/j.febslet.2009.04.005
20215531Germline BRCA mutations denote a clinicopathologic subset of prostate cancer.Clin Cancer Res2010 Apr 1Gallagher DJdoi: 10.1158/1078-0432.CCR-09-2871
25783183Hypermethylation of BRCA1 gene: implication for prognostic biomarker and therapeutic target in sporadic primary triple-negative breast cancer.Breast Cancer Res Treat2015 AprZhu Xdoi: 10.1007/s10549-015-3338-y
18957670Skewed X chromosome inactivation and breast and ovarian cancer status: evidence for X-linked modifiers of BRCA1.J Natl Cancer Inst2008 Nov 5Lose Fdoi: 10.1093/jnci/djn345
21276604Improved survival in non-Ashkenazi Jewish ovarian cancer patients with BRCA1 and BRCA2 gene mutations.Gynecol Oncol2011 May 1Lacour RAdoi: 10.1016/j.ygyno.2010.12.354
17635951Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: a report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group.J Clin Oncol2007 Sep 1Brohet RM-
12237273Cancer risks in BRCA1 carriers: time for the next generation of studies.J Natl Cancer Inst2002 Sep 18Gruber SB-
17039264Role of single nucleotide polymorphisms and haplotypes in BRCA1 in breast cancer: Czech case-control study.Breast Cancer Res Treat2007 JunSoucek P-
11916966A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer.J Biol Chem2002 Jun 7Li H-
18936947The effect of symptom duration in epithelial ovarian cancer on prognostic factors.Arch Gynecol Obstet2009 JunMenczer Jdoi: 10.1007/s00404-008-0814-1
24477976Long-term prognosis of early-onset breast cancer in a population-based cohort with a known BRCA1/2 mutation status.Breast Cancer Res Treat2014 FebNilsson MPdoi: 10.1007/s10549-014-2842-9
23954390Co-occurrence of multiple sclerosis and cancer in a BRCA1 positive family.Eur J Med Genet2013 OctHolzmann Cdoi: 10.1016/j.ejmg.2013.07.006
25980896Psychological distress related to BRCA testing in ovarian cancer patients.Fam Cancer2015 DecBjrnslett Mdoi: 10.1007/s10689-015-9811-2.
26402875Germline Mutations of BRCA1 and BRCA2 in Korean Ovarian Cancer Patients: Finding Founder Mutations.Int J Gynecol Cancer2015 OctChoi MCdoi: 10.1097/IGC.0000000000000529.
26949839CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumor suppressor deficiency-related changes in healthy tissue.Epigenetics2016Etzold Adoi: 10.1080/15592294.2016.1140295
16026807BRCA1 mutations and polymorphisms in a hospital-based consecutive series of breast cancer patients from Apulia, Italy.Mutat Res2005 Oct 15Tommasi S-
23262210Characteristics of women with ovarian carcinoma who have BRCA1 and BRCA2 mutations not identified by clinical testing.Gynecol Oncol2013 MarNorquist BMdoi: 10.1016/j.ygyno.2012.12.015
26439132BRCA1 and BRCA2 mutations in Japanese patients with ovarian, fallopian tube, and primary peritoneal cancer.Cancer2016 Jan 1Sakamoto Idoi: 10.1002/cncr.29707
21984204Appendectomy and cancer risk in Jewish BRCA1 and BRCA2 mutation carriers.Breast Cancer Res Treat2012 FebBernholtz Sdoi: 10.1007/s10549-011-1807-5
24947589First recurrent large genomic rearrangement in the BRCA1 gene found in Poland.Cancer Epidemiol2014 AugRudnicka Hdoi: 10.1016/j.canep.2014.05.010
18034184Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations.Nat Rev Cancer2007 DecFackenthal JD-
21427728Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2.Br J Cancer2011 Apr 12Osorio Adoi: 10.1038/bjc.2011.91
21557934Peripheral blood DNA methylation detected in the BRCA1 or BRCA2 promoter for sporadic ovarian cancer patients and controls.Clin Chim Acta2011 Jul 15Bosviel Rdoi: 10.1016/j.cca.2011.04.027
18257128BRCA1/2 associated hereditary breast cancer.J Zhejiang Univ Sci B2008 FebTeng LSdoi: 10.1631/jzus.B0710617.
25892146BRCA1 and BRCA2 mutation type associated with cancer risk.Lancet Oncol2015 MayBurki TKdoi: 10.1016/S1470-2045(15)70187-7
22655046Full-exon pyrosequencing screening of BRCA germline mutations in Mexican women with inherited breast and ovarian cancer.PLoS One2012Vaca-Paniagua Fdoi: 10.1371/journal.pone.0037432
22684231BRCA1 and BRCA2 unclassified variants and missense polymorphisms in Algerian breast/ovarian cancer families.Dis Markers2012Cherbal Fdoi: 10.3233/DMA-2012-0893.
20882403BRCA1 promoter methylation in peripheral blood cells is associated with increased risk of breast cancer with BRCA1 promoter methylation.Breast Cancer Res Treat2011 AugIwamoto Tdoi: 10.1007/s10549-010-1188-1
26028024Breast and ovarian cancer predisposition due to de novo BRCA1 and BRCA2 mutations.Oncogene2016 Mar 10Golmard Ldoi: 10.1038/onc.2015.181
25808098Bilateral risk-reduction mastectomy in BRCA1 and BRCA2 mutation carriers: a meta-analysis.Ann Surg Oncol2015 SepDe Felice Fdoi: 10.1245/s10434-015-4532-1
21161372Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status.Breast Cancer Res Treat2011 JunFigueiredo JCdoi: 10.1007/s10549-010-1285-1
25756400Endometrial cancers in mutation carriers from hereditary breast ovarian cancer syndrome kindreds: report from the Creighton University Hereditary Cancer Registry with review of the implications.Int J Gynecol Cancer2015 MayCasey MJdoi: 10.1097/IGC.0000000000000402.
19035463Time to stop ovarian cancer screening in BRCA1/2 mutation carriers?Int J Cancer2009 Feb 15van der Velde NMdoi: 10.1002/ijc.24038.
13679996BRCA1 and p53: compensatory roles in DNA repair.J Mol Med (Berl)2003 NovHartman AR-
25526195Germline mutations of DICER1 in Chinese women with BRCA1/BRCA2-negative familial breast cancer.Genet Mol Res2014 Dec 18Cao WMdoi: 10.4238/2014.December.18.16.
21649643Assessment of the prevalence of de novo mutations in the BRCA1 and BRCA2 genes.Clin Genet2011 JulZhang Ldoi: 10.1111/j.1399-0004.2011.01691.x.
18694767Molecular and in silico analysis of BRCA1 and BRCA2 variants.Mutat Res2008 Sep 26Tommasi Sdoi: 10.1016/j.mrfmmm.2008.07.005
19370414Parity and the risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers.Breast Cancer Res Treat2010 JanMilne RLdoi: 10.1007/s10549-009-0394-1
24884718Genome instability in blood cells of a BRCA1+ breast cancer family.BMC Cancer2014 May 19Xiao Fdoi: 10.1186/1471-2407-14-342.
19123044Haplotype and quantitative transcript analyses of Portuguese breast/ovarian cancer families with the BRCA1 R71G founder mutation of Galician origin.Fam Cancer2009Santos Cdoi: 10.1007/s10689-008-9229-1
25503195Hereditary cancer-associated mutations in women diagnosed with two primary cancers: an opportunity to identify hereditary cancer syndromes after the first cancer diagnosis.Oncology2015Saam Jdoi: 10.1159/000368836
25085752Development and validation of a new algorithm for the reclassification of genetic variants identified in the BRCA1 and BRCA2 genes.Breast Cancer Res Treat2014 AugPruss Ddoi: 10.1007/s10549-014-3065-9
12474142Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene.Am J Hum Genet2003 JanEdwards SM-
24700448Validation of the Manchester scoring system for predicting BRCA1/2 mutations in 9,390 families suspected of having hereditary breast and ovarian cancer.Int J Cancer2014 Nov 15Kast Kdoi: 10.1002/ijc.28875
19499246BRCA1 and BRCA2 germline mutations in Korean ovarian cancer patients.J Cancer Res Clin Oncol2009 NovLim MCdoi: 10.1007/s00432-009-0607-3
22962264Targeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-Ribose) polymerase inhibition.Cancer Res2012 Nov 1Yang ESdoi: 10.1158/0008-5472.CAN-12-0934
19491284Breast cancer in young women (YBC): prevalence of BRCA1/2 mutations and risk of secondary malignancies across diverse racial groups.Ann Oncol2009 OctHaffty BGdoi: 10.1093/annonc/mdp051
26299666Differential Gene Expression of BRCA1,ERBB2 and TP53 biomarkers between Human Breast Tissue and Peripheral Blood Samples of Breast Cancer.Anticancer Agents Med Chem2016Zghair AN-
23292835Prognostic significance of BRCA1 expression in gastric cancer.Med Oncol2013 MarChen Wdoi: 10.1007/s12032-012-0423-5
21537840Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women.Int J Oncol2011 JulAl-Moghrabi Ndoi: 10.3892/ijo.2011.1021
21424757Adequacy of risk-reducing gynaecologic surgery in BRCA1 or BRCA2 mutation carriers and other women at high risk of pelvic serous cancer.Fam Cancer2011 SepKiely BEdoi: 10.1007/s10689-011-9435-0.
16450717[Prophylactic oophorectomy among carriers of BRCA1/2 mutations--demographic and pathologic data].Harefuah2006 JanDaum H-
23640417Screening for genomic rearrangements at BRCA1 locus in Iranian women with breast cancer using multiplex ligation-dependent probe amplification.J Genet2013 AprYassaee VR-
12237285Inactivation of BRCA1 and BRCA2 in ovarian cancer.J Natl Cancer Inst2002 Sep 18Hilton JL-
18334730Complete mutation screening and haplotype characterization of BRCA1 gene in Tunisian patients with familial breast cancer.Cancer Biomark2008Troudi W-
25711630High efficacy of cisplatin neoadjuvant therapy in a prospective series of patients carrying BRCA1 germ-line mutation.Med Oncol2015 AprMoiseyenko VMdoi: 10.1007/s12032-015-0514-1
20940403BRCA1-IRIS overexpression promotes cisplatin resistance in ovarian cancer cells.Cancer Res2010 Nov 1Chock KLdoi: 10.1158/0008-5472.CAN-10-1352
25868867Factors associated with genetic counseling and BRCA testing in a population-based sample of young Black women with breast cancer.Breast Cancer Res Treat2015 MayCragun Ddoi: 10.1007/s10549-015-3374-7
16718381Analysis of loss of heterozygosity and immunohistochemistry in BRCA1 gene in sporadic breast cancers.Mol Cell Biochem2006 JulDinesh KP-
24729269BRCA1 point mutations in premenopausal breast cancer patients from Central Sudan.Fam Cancer2014 SepBiunno Idoi: 10.1007/s10689-014-9717-4.
22744714DNA methylation of circulating DNA: a marker for monitoring efficacy of neoadjuvant chemotherapy in breast cancer patients.Tumour Biol2012 DecSharma Gdoi: 10.1007/s13277-012-0443-y
20505321Basal-like breast cancer displays distinct patterns of promoter methylation.Cancer Biol Ther2010 Jun 15Lee JS-
22768030Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.PLoS One2012Kirchhoff Tdoi: 10.1371/journal.pone.0035706
25987085Consanguinity Protecting Effect Against Breast Cancer among Tunisian Women: Analysis of BRCA1 Haplotypes.Asian Pac J Cancer Prev2015Medimegh I-
25520075BRCA1 promoter hypermethylation signature for early detection of breast cancer in the Vietnamese population.Asian Pac J Cancer Prev2014Truong PK-
22752604BRCA1/BRCA2 gene mutations/SNPs and BRCA1 haplotypes in early-onset breast cancer patients of Indian ethnicity.Med Oncol2012 DecJuwle Adoi: 10.1007/s12032-012-0294-9
18501021Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families.BMC Cancer2008 May 26Pylks Kdoi: 10.1186/1471-2407-8-146.
19079346Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1.Oncogene2009 Feb 12Gonzalez MEdoi: 10.1038/onc.2008.433
26026974BRCA1 and BRCA2 mutations in males with familial breast and ovarian cancer syndrome. Results of a Spanish multicenter study.Fam Cancer2015 Decde Juan Idoi: 10.1007/s10689-015-9814-z.
18375895Clinical classification of BRCA1 and BRCA2 DNA sequence variants: the value of cytokeratin profiles and evolutionary analysis--a report from the kConFab Investigators.J Clin Oncol2008 Apr 1Spurdle ABdoi: 10.1200/JCO.2007.13.2779.
24479546RNA profiling reveals familial aggregation of molecular subtypes in non-BRCA1/2 breast cancer families.BMC Med Genomics2014 Jan 31Larsen MJdoi: 10.1186/1755-8794-7-9.
26181175Effect of Oophorectomy on Survival After Breast Cancer in BRCA1 and BRCA2 Mutation Carriers.JAMA Oncol2015 JunMetcalfe Kdoi: 10.1001/jamaoncol.2015.0658.
15285306The presence of hereditary BRCA1 gene mutations in women with familial breast or ovarian cancer and the frequency of occurrence of these tumours in their relatives.Eur J Gynaecol Oncol2004Skasko E-
19619314A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population.BMC Cancer2009 Jul 20Palomba Gdoi: 10.1186/1471-2407-9-245.
18000219Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.J Natl Cancer Inst2007 Nov 21Hosey AM-
11793480BRCA1 and BRCA2 mutations in Russian familial breast cancer.Hum Mutat2002 FebTereschenko IV-
25454609Effect of BRCA Mutations on Metastatic Relapse and Cause-specific Survival After Radical Treatment for Localised Prostate Cancer.Eur Urol2015 AugCastro Edoi: 10.1016/j.eururo.2014.10.022
25136623BRCA-associated ovarian cancer: from molecular genetics to risk management.Biomed Res Int2014Girolimetti Gdoi: 10.1155/2014/787143
15917310BRCA1 and BRCA2 as ovarian cancer susceptibility genes.Carcinogenesis2005 OctSowter HM-
23867999Deleterious BRCA1/2 mutation is an independent risk factor for carboplatin hypersensitivity reactions.Br J Cancer2013 Aug 20Moon DHdoi: 10.1038/bjc.2013.389
19405875The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor.Genet Test Mol Biomarkers2009 JunPongsavee Mdoi: 10.1089/gtmb.2008.0127.
21484799Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers.Int J Cancer2012 Mar 15Dick MGdoi: 10.1002/ijc.26134
18712473The variants BRCA1 IVS6-1G>A and BRCA2 IVS15+1G>A lead to aberrant splicing of the transcripts.Breast Cancer Res Treat2009 SepGuti??rrez-Enr??quez Sdoi: 10.1007/s10549-008-0154-7
26085381BRCA1 gene variant p.P142H associated with male breast cancer: a two-generation genealogic study and literature review.Fam Cancer2015 DecSpinelli Cdoi: 10.1007/s10689-015-9819-7.
19214744CASP8 D302H polymorphism delays the age of onset of breast cancer in BRCA1 and BRCA2 carriers.Breast Cancer Res Treat2010 JanPalanca Suela Sdoi: 10.1007/s10549-009-0316-2
16940443BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells.J Clin Endocrinol Metab2006 NovLu M-
12237897Survival in prospectively ascertained familial breast cancer: analysis of a series stratified by tumour characteristics, BRCA mutations and oophorectomy.Int J Cancer2002 Oct 20Mller P-
27068824Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population.Breast Cancer2017 MarParvin Sdoi: 10.1007/s12282-016-0692-5
22179631Loss of heterozygosity at BRCA1 locus is significantly associated with aggressiveness and poor prognosis in breast cancer.Ann Surg Oncol2012 MayOkada Sdoi: 10.1245/s10434-011-2166-5
25376744Methylation of the BRCA1 promoter in peripheral blood DNA is associated with triple-negative and medullary breast cancer.Breast Cancer Res Treat2014 DecGupta Sdoi: 10.1007/s10549-014-3179-0
18175216The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation.Breast Cancer Res Treat2008 DecChoi DHdoi: 10.1007/s10549-007-9878-z
19876733The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers.Breast Cancer Res Treat2010 JunJakubowska Adoi: 10.1007/s10549-009-0595-7
24191908BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer.BMC Cancer2013 Nov 5Jacot Wdoi: 10.1186/1471-2407-13-523.
20309627Evaluation of established breast cancer risk factors as modifiers of BRCA1 or BRCA2: a multi-center case-only analysis.Breast Cancer Res Treat2010 NovMoorman PGdoi: 10.1007/s10549-010-0842-y
19584272Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.Cancer Res2009 Jul 15Rebbeck TRdoi: 10.1158/0008-5472.CAN-09-0625
23039163Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers.BMC Cancer2012 Oct 5Bjrnslett Mdoi: 10.1186/1471-2407-12-454.
12505256Analysis of BRCA1, TP53, and TSG101 germline mutations in German breast and/or ovarian cancer families.Cancer Genet Cytogenet2002 Oct 15Balz V-
24752797Development of serous ovarian cancer is associated with the expression of homologous recombination pathway proteins.Pathol Oncol Res2014 OctYe Qdoi: 10.1007/s12253-014-9776-8
24285858Breast and ovarian cancer risks in a large series of clinically ascertained families with a high proportion of BRCA1 and BRCA2 Dutch founder mutations.J Med Genet2014 FebBrohet RMdoi: 10.1136/jmedgenet-2013-101974
18165636Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancer.J Clin Oncol2008 Jan 1Chetrit Adoi: 10.1200/JCO.2007.11.6905.
21135055An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients.Ann Oncol2011 JulVollebergh MAdoi: 10.1093/annonc/mdq624
25445393BRCA mutations cause reduction in miR-200c expression in triple negative breast cancer.Gene2015 Feb 10Erturk Edoi: 10.1016/j.gene.2014.11.047
23879077Screening for BRCA1 large genomic rearrangements in female Egyptian hereditary breast cancer patients.East Mediterr Health J2013 MarHagag E-
26171949Occurrence of a non deleterious gene conversion event in the BRCA1 gene.Genes Chromosomes Cancer2015 OctTessereau Cdoi: 10.1002/gcc.22278
24342616HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.Biochem Biophys Res Commun2014 Feb 14Wang Xdoi: 10.1016/j.bbrc.2013.12.053
23615136Large genomic rearrangements in BRCA1 and BRCA2: implications for patient care.Oncol Nurs Forum2013 May 1Mahon SMdoi: 10.1188/13.ONF.220-222.
18340530BRCA1 2080insA mutation in familial breast cancer.Breast Cancer Res Treat2009 FebAlansari ASdoi: 10.1007/s10549-008-9961-0
19615284[Correlation of BRCA1 and APC aberrant methylation with the response to anthracycline-based neoadjuvant chemotherapy in primary breast cancer].Zhonghua Zhong Liu Za Zhi2009 AprYuan P-
19656774Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers.Hum Mol Genet2009 Nov 15Antoniou ACdoi: 10.1093/hmg/ddp372
19802015Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin.Oncogene2010 Jan 7Wolf Idoi: 10.1038/onc.2009.301
16724249Low prevalence of BRCA1 exon rearrangements in familial and young sporadic breast cancer patients.Fam Cancer2006Ellis D-
17406974BRCA1 disease-associated haplotypes in Singapore Malay women with early-onset breast/ovarian cancer.Breast Cancer Res Treat2007 SepAli AB-
23918944Tamoxifen and risk of contralateral breast cancer for BRCA1 and BRCA2 mutation carriers.J Clin Oncol2013 Sep 1Phillips KAdoi: 10.1200/JCO.2012.47.8313
23740344International rates of breast reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers.Ann Surg Oncol2013 NovSemple Jdoi: 10.1245/s10434-013-3040-4
25311111Use of risk-reducing surgeries in a prospective cohort of 1,499 BRCA1 and BRCA2 mutation carriers.Breast Cancer Res Treat2014 NovChai Xdoi: 10.1007/s10549-014-3134-0
19268590PALB2 links BRCA1 and BRCA2 in the DNA-damage response.Curr Biol2009 Mar 24Zhang Fdoi: 10.1016/j.cub.2009.02.018
25195694BRCA1 and BRCA2 mutations and the risk for colorectal cancer.Clin Genet2015 MaySopik Vdoi: 10.1111/cge.12497
21394826Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary.Hum Mutat2011 JunWhiley PJdoi: 10.1002/humu.21495
17253935Lack of germ-line promoter methylation in BRCA1-negative families with familial breast cancer.Genet Test2006 WinterChen Y-
25194442Association between BRCA1 rs799917 polymorphism and breast cancer risk: A meta-analysis of 19,878 subjects.Biomed Pharmacother2014 SepQin TTdoi: 10.1016/j.biopha.2014.08.006
19383375The contribution of BRCA1 and BRCA2 to ovarian cancer.Mol Oncol2009 AprRamus SJdoi: 10.1016/j.molonc.2009.02.001
25927284BRCA1 deficiency in ovarian cancer is associated with alteration in expression of several key regulators of cell motility - A proteomics study.Cell Cycle2015Gau DMdoi: 10.1080/15384101.2015.1036203.
22488590Inhibition of constitutively activated phosphoinositide 3-kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1-defective breast cancer cells.Mol Carcinog2013 SepYi YWdoi: 10.1002/mc.21905
19098453BRCA1 mutations contribute to cell motility and invasion by affecting its main regulators.Cell Cycle2008 DecYasmeen A-
22167321Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NF??B pathway.Breast Cancer Res Treat2012 JulTanic Mdoi: 10.1007/s10549-011-1905-4
18097605BRCA1 and BRCA2 point mutations and large rearrangements in breast and ovarian cancer families in Northern Poland.Oncol Rep2008 JanRatajska M-
26029931Thyroid Hormone Receptors Predict Prognosis in BRCA1 Associated Breast Cancer in Opposing Ways.PLoS One2015 Jun 1Heublein Sdoi: 10.1371/journal.pone.0127072
18413372Screening for familial ovarian cancer: poor survival of BRCA1/2 related cancers.J Med Genet2009 SepEvans DGdoi: 10.1136/jmg.2008.058248
14729053Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain.Exp Cell Res2004 Feb 1Rodriguez JA-
28407998A Cost-Effectiveness Evaluation of Germline BRCA1 and BRCA2 Testing in UK Women with Ovarian Cancer.Value Health2017 AprEccleston Adoi: 10.1016/j.jval.2017.01.004
27928164Comparison between CaGene 5.1 and 6.0 for BRCA1/2 mutation prediction: a retrospective study of 150 BRCA1/2 genetic tests in 517 families with breast/ovarian cancer.J Hum Genet2017 MarAntonucci Idoi: 10.1038/jhg.2016.138
28120435Oncotype Dx recurrence score among BRCA1/2 germline mutation carriers with hormone receptors positive breast cancer.Int J Cancer2017 May 1Halpern Ndoi: 10.1002/ijc.30616
27430397Very high uptake of risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers: A single-center experience.Gynecol Oncol2016 OctHarmsen MGdoi: 10.1016/j.ygyno.2016.07.104
27362900The Prognostic Value of BRCA1 and PARP Expression in Epithelial Ovarian Carcinoma: Immunohistochemical Detection.Int J Gynecol Pathol2017 MarHjortkjr Mdoi: 10.1097/PGP.0000000000000310.
28184945First description of a double heterozygosity for BRCA1 and BRCA2 pathogenic variants in a French metastatic breast cancer patient: A case report.Oncol Rep2017 MarMeynard Gdoi: 10.3892/or.2017.5422
28183138Overall survival and clinical characteristics of BRCA mutation carriers with stage I/II pancreatic cancer.Br J Cancer2017 Mar 14Golan Tdoi: 10.1038/bjc.2017.19
27693788Enforced expression of hsa-miR-125a-3p in breast cancer cells potentiates docetaxel sensitivity via modulation of BRCA1 signaling.Biochem Biophys Res Commun2016 Oct 28Xu Xdoi: 10.1016/j.bbrc.2016.09.087
26926928Common variation in BRCA1 may have a role in progression to lethal prostate cancer after radiation treatment.Prostate Cancer Prostatic Dis2016 JunSanchez Adoi: 10.1038/pcan.2016.4
26541979Evaluation of germline BRCA1 and BRCA2 mutations in a multi-ethnic Asian cohort of ovarian cancer patients.Gynecol Oncol2016 MayHasmad HNdoi: 10.1016/j.ygyno.2015.11.001
27272763Association Between BRCA Status and P53 Status in Breast Cancer: A Meta-Analysis.Med Sci Monit2016 Jun 8Peng L-
27798111The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.Hum Mol Genet2016 Dec 15Dickson KAdoi: 10.1093/hmg/ddw362.
27239795Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.Nat Struct Mol Biol2016 JulDensham RMdoi: 10.1038/nsmb.3236
27225819BRCA1-2 diagnostic workflow from next-generation sequencing technologies to variant identification and final report.Genes Chromosomes Cancer2016 OctPilato Bdoi: 10.1002/gcc.22383
28247011Population pharmacokinetics of ABT-767 in BRCA1 or BRCA2 mutation carriers with advanced solid tumors or in subjects with high grade serous ovarian, primary peritoneal or fallopian tube cancer.Cancer Chemother Pharmacol2017 MarMittapalli RKdoi: 10.1007/s00280-017-3262-4
27623744The impact of an expanded genetic testing program and selective oophorectomy on the incidence of ovarian cancer in West Pomerania.Clin Genet2017 FebMenkiszak Jdoi: 10.1111/cge.12865
28024868Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer.Gastroenterology2017 AprSahasrabudhe Rdoi: 10.1053/j.gastro.2016.12.010
27484786Expression of cancer related BRCA1 missense variants decreases MMS-induced recombination in Saccharomyces cerevisiae without altering its nuclear localization.Cell Cycle2016 Oct 17Lodovichi Sdoi: 10.1080/15384101.2016.1215389
28212807Prevalence of BRCA1 and BRCA2 large genomic rearrangements in Tunisian high risk breast/ovarian cancer families: Implications for genetic testing.Cancer Genet2017 JanRiahi Adoi: 10.1016/j.cancergen.2016.11.002
26785832Mutation screening of MIR146A/B and BRCA1/2 3'-UTRs in the GENESIS study.Eur J Hum Genet2016 AugGarcia AIdoi: 10.1038/ejhg.2015.284
27197267The BRCA1-??11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.Cancer Res2016 May 1Wang Ydoi: 10.1158/0008-5472.CAN-16-0186.
28079255Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.FEBS Lett2017 AprKolinjivadi AMdoi: 10.1002/1873-3468.12556
28551646Primary Peritoneal Serous Carcinoma in Men: A Rare and Non-BRCA-associated Entity.Anticancer Res2017 JunNeuhausen SL-
26300001The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability.Oncogene2016 May 5L??ddecke Sdoi: 10.1038/onc.2015.290
27373334BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.