EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19012002	Expression profile of BRCA1 and BRCA2 genes in premenopausal Mexican women with breast cancer: clinical and immunohistochemical correlates.	Med Oncol	2009	Loredo-Pozos G	doi: 10.1007/s12032-008-9114-7
28900739	A frameshift mutation in BRCA1 leads to hereditary breast and ovarian cancer in one part of a family and to familial pancreatic cancer in another.	Breast Cancer Res Treat	2018 Jan	Gieldon L	doi: 10.1007/s10549-017-4500-5
26392358	Methylation biomarkers for pleomorphic lobular breast cancer - a short report.	Cell Oncol (Dordr)	2015 Oct	Moelans CB	doi: 10.1007/s13402-015-0241-9
24915755	A germline mutation in the BRCA1 3'UTR predicts Stage IV breast cancer.	BMC Cancer	2014 Jun 10	Dorairaj JJ	doi: 10.1186/1471-2407-14-421.
21781528	[The correlation between chemotherapeutic efficacy and breast cancer susceptibility gene 1 and class IIIβ-tubulin protein expression in non-small cell lung cancer patients].	Zhonghua Nei Ke Za Zhi	2011 Jun	Wan YY	doi: 10.3760/cma.j.issn.0578-142.2011.06.006.
24335192	EZH2 participates in malignant biological behavior of epithelial ovarian cancer through regulating the expression of BRCA1.	Cancer Biol Ther	2014 Mar 1	Li T	doi: 10.4161/cbt.27306
25319390	miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.	Mol Cancer Ther	2014 Dec	Tang H	doi: 10.1158/1535-7163.MCT-14-0243
25132263	BRCA1-IRIS inactivation sensitizes ovarian tumors to cisplatin.	Oncogene	2015 Jun 4	Paul BT	doi: 10.1038/onc.2014.237
16543155	A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination.	Mol Cell	2006 Mar 17	Brzovic PS	-
25480944	TUSC4 functions as a tumor suppressor by regulating BRCA1 stability.	Cancer Res	2015 Jan 15	Peng Y	doi: 10.1158/0008-5472.CAN-14-2315
22579790	Outcomes of primary surgical cytoreduction in patients with BRCA-associated high-grade serous ovarian carcinoma.	Gynecol Oncol	2012 Aug	Hyman DM	doi: 10.1016/j.ygyno.2012.05.001
14576434	Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2.	Science	2003 Oct 24	King MC	-
23047605	Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production.	Cell Cycle	2012 Nov 15	Salem AF	doi: 10.4161/cc.22316
12607598	Frequent loss of BRCA1 nuclear expression in young women with breast cancer: an immunohistochemical study from an area of low incidence but early onset.	Appl Immunohistochem Mol Morphol	2002 Dec	Lee WY	-
18445692	Loss of heterozygosity at the BRCA2 locus detected by multiplex ligation-dependent probe amplification is common in prostate cancers from men with a germline BRCA2 mutation.	Clin Cancer Res	2008 May 15	Willems AJ	doi: 10.1158/1078-0432.CCR-07-5237
22931600	[BRCA1 inhibits progesterone-induced proliferation and migration of breast cancer cells].	Nan Fang Yi Ke Da Xue Xue Bao	2012 Aug	Xiong J	-
16011248	[Genetic instability on chromosome 17q21 in gastric cancer of Chinese patients].	Shi Yan Sheng Wu Xue Bao	2005 Apr	Lin XQ	-
25522926	Tumor-associated inflammation as a potential prognostic tool in BRCA1/2-associated breast cancer.	Hum Pathol	2015 Feb	van Verschuer VM	doi: 10.1016/j.humpath.2014.10.020
24935384	No association between BRCA1 immunohistochemical expression and tumor grade, stage or overall survival in platinum-treated epithelial ovarian cancer patients.	Asian Pac J Cancer Prev	2014	Shawky Ael-A	-
16945238	Medullary carcinoma of breast with a novel germline mutation 1123T >G in exon 11 of BRCA1.	J Coll Physicians Surg Pak	2006 Sep	Moattar T	-
18045956	Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations.	Endocr Relat Cancer	2007 Dec	Hudelist G	-
27008870	Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms.	Hum Mol Genet	2016 Jun 1	de la Hoya M	-
28358361	Tumor-treating fields elicit a conditional vulnerability to ionizing radiation via the downregulation of BRCA1 signaling and reduced DNA double-strand break repair capacity in non-small cell lung cancer cell lines.	Cell Death Dis	2017 Mar 30	Karanam NK	doi: 10.1038/cddis.2017.136.
29712865	Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1.	Proc Natl Acad Sci U S A	2018 May 15	Seo A	doi: 10.1073/pnas.1801796115
29970689	Extent of breast cancer type 1 promoter methylation correlates with clinicopathological features in breast cancers.	J Cancer Res Ther	2018 Jun	Sun MY	doi: 10.4103/0973-1482.235354.
30733286	AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.	Proc Natl Acad Sci U S A	2019 Feb 26	Kubli SP	doi: 10.1073/pnas.1815126116
26048987	Deciphering the BRCA1 Tumor Suppressor Network.	J Biol Chem	2015 Jul 17	Jiang Q	doi: 10.1074/jbc.R115.667931
20389018	HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.	J Clin Invest	2010 May	Gilbert PM	doi: 10.1172/JCI39534
25496700	Plasma mRNA expression levels of BRCA1 and TS as potential predictive biomarkers for chemotherapy in gastric cancer.	J Transl Med	2014 Dec 14	Shen J	doi: 10.1186/s12967-014-0355-2.
28376175	Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers.	J Natl Cancer Inst	2017 Jul 1	Kuchenbaecker KB	doi: 10.1093/jnci/djw302.
20845286	Induction of breast cancer in wild type p53 cells by BRCA1-IRIS overexpression.	Hawaii Med J	2010 Aug	Elshamy WM	-
27249681	Women's Health Issues for BRCA Mutation Carriers.	Am Soc Clin Oncol Educ Book	2016	Sabatini ME	doi: 10.14694/EDBK_100001.
28364669	Suggestion of BRCA1 c.5339T>C (p.L1780P) variant confer from 'unknown significance' to 'Likely pathogenic' based on clinical evidence in Korea.	Breast	2017 Jun	Ryu JM	doi: 10.1016/j.breast.2017.03.006
16772120	Gross rearrangements in BRCA1 but not BRCA2 play a notable role in predisposition to breast and ovarian cancer in high-risk families of German origin.	Cancer Genet Cytogenet	2006 Jul 1	Preisler-Adams S	-
26588056	Risk-reducing surgery in BRCA 1/2 mutation carries: a point of view.	Oncotarget	2015 Nov 24	De Felice F	doi: 10.18632/oncotarget.6348.
26989051	Male breast cancer is not congruent with the female disease.	Crit Rev Oncol Hematol	2016 May	Fentiman IS	doi: 10.1016/j.critrevonc.2016.02.017
26414677	Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.	Nat Genet	2015 Nov	Day FR	doi: 10.1038/ng.3412
12096901	Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.	J Mol Biol	2002 Jul 12	Ekblad CM	-
12509456	Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.	Mol Cell Biol	2003 Jan	Miralem T	-
26715507	Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis.	BMC Cancer	2015 Dec 29	Romagnolo DF	doi: 10.1186/s12885-015-2044-9.
27003155	NGS-based BRCA1/2 mutation testing of high-grade serous ovarian cancer tissue: results and conclusions of the first international round robin trial.	Virchows Arch	2016 Jun	Endris V	doi: 10.1007/s00428-016-1919-8
20032382	Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer.	Anticancer Res	2009 Nov	Schjlberg AR	-
19120025	Cloning and functional identification of two novel BRCA1 splicing variants.	Biochemistry (Mosc)	2008 Nov	Miao L	-
21946536	Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.	Nat Med	2011 Sep 25	Chang S	doi: 10.1038/nm.2459.
17307836	Cancer risks in carriers of the BRCA1/2 Ashkenazi founder mutations.	J Med Genet	2007 Jul	Kadouri L	-
24168967	miR-9 regulation of BRCA1 and ovarian cancer sensitivity to cisplatin and PARP inhibition.	J Natl Cancer Inst	2013 Nov 20	Sun C	doi: 10.1093/jnci/djt302
23155271	Prognostic significance of ERCC1, RRM1 and BRCA1 in surgically-treated patients with non-small cell lung cancer.	Anticancer Res	2012 Nov	Pesta M	-
26745875	BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing.	Oncotarget	2016 Jan 12	Mafficini A	doi: 10.18632/oncotarget.6834.
16843262	Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature.	Cancer Cell	2006 Jul	Furuta S	-
17505536	Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia.	Int J Biol Sci	2007 Apr 25	Hoshino A	-
16326698	BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase.	J Biol Chem	2006 Feb 10	Moreau K	-
20581465	BRCA1 regulation of base excision repair pathway.	Cell Cycle	2010 Jul 1	Saha T	doi: 10.4161/cc.9.13.12084.
24675954	Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.	Science	2014 Mar 28	Venkitaraman AR	doi: 10.1126/science.1252230.
22382806	Prevalence of BRCA1 and BRCA2 mutations in non-familial breast cancer patients with high risks in Korea: the Korean Hereditary Breast Cancer (KOHBRA) Study.	Breast Cancer Res Treat	2012 Jun	Son BH	doi: 10.1007/s10549-012-2001-0
16782705	BRCA1 interacts with poly(A)-binding protein: implication of BRCA1 in translation regulation.	J Biol Chem	2006 Aug 25	Dizin E	-
15665273	Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.	Cancer Res	2005 Jan 1	Hayami R	-
17000754	Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions.	Mol Cell Biol	2006 Dec	Bartz SR	-
26227317	Association of HO-1 and BRCA1 Is Critical for the Maintenance of Cellular Homeostasis in Prostate Cancer.	Mol Cancer Res	2015 Nov	Labanca E	doi: 10.1158/1541-7786.MCR-15-0150-T
22392482	Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-γ.	Apoptosis	2012 Jul	Warrener P	doi: 10.1007/s10495-012-0707-4.
25216750	ABCG2, a novel antigen to sort luminal progenitors of BRCA1- breast cancer cells.	Mol Cancer	2014 Sep 12	Leccia F	doi: 10.1186/1476-4598-13-213.
17921118	Immunolocalization of BRCA1 protein in tumor breast tissue: prescreening of BRCA1 mutation in Tunisian patients with hereditary breast cancer?	Eur J Histochem	2007 Jul-Sep	Troudi W	-
20890790	[Genes beyond BRCA1 and BRCA2 for hereditary breast cancer].	Wien Med Wochenschr	2010 Nov	Simon K	doi: 10.1007/s10354-010-0831-0.
12086871	The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients.	Cancer Cell	2002 Mar	Elledge SJ	-
25884417	BRCA1 Alternative splicing landscape in breast tissue samples.	BMC Cancer	2015 Apr 3	Romero A	doi: 10.1186/s12885-015-1145-9.
16969499	Missense mutations of BRCA1 gene affect the binding with p53 both in vitro and in vivo.	Oncol Rep	2006 Oct	Quaresima B	-
23567481	Breast cancer size estimation with MRI in BRCA mutation carriers and other high risk patients.	Eur J Radiol	2013 Sep	Mann RM	doi: 10.1016/j.ejrad.2013.03.003
22172724	BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.	Cancer Cell	2011 Dec 13	Drost R	doi: 10.1016/j.ccr.2011.11.014.
21729660	Development of breast cancer in a 21-year-old childhood Wilms' tumor survivor with a BRCA1 2634delC mutation.	Clin Breast Cancer	2011 Aug	Dulude AM	doi: 10.1016/j.clbc.2010.11.001
23674270	BRCA1 polymorphisms and breast cancer epidemiology in the Western New York exposures and breast cancer (WEB) study.	Genet Epidemiol	2013 Jul	Ricks-Santi LJ	doi: 10.1002/gepi.21730
23047606	Hereditary ovarian cancer and two-compartment tumor metabolism: epithelial loss of BRCA1 induces hydrogen peroxide production, driving oxidative stress and NF??B activation in the tumor stroma.	Cell Cycle	2012 Nov 15	Martinez-Outschoorn UE	doi: 10.4161/cc.22226
15009718	Downregulation of BRCA1 in A375 melanoma cell line increases radio-sensitivity and modifies metastatic and angiogenic gene expression.	J Invest Dermatol	2004 Feb	Hesling C	-
18683754	[Influence of mifepristone on DNA repair genes and cisplatin sensitivity in human ovarian cancer drug-resistance cells].	Zhonghua Fu Chan Ke Za Zhi	2008 Feb	Liu GY	-
16940470	Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells.	Am J Physiol Endocrinol Metab	2007 Jan	Ghosh S	-
21344391	Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins.	J Cell Physiol	2011 Dec	Qin Y	doi: 10.1002/jcp.22695.
25460500	Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells.	Oncotarget	2014 Dec 15	Pickholtz I	-
23860775	MYC overexpression and poor prognosis in sporadic breast cancer with BRCA1 deficiency.	Tumour Biol	2013 Dec	Ren J	doi: 10.1007/s13277-013-0983-9
20103620	Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination.	Cancer Res	2010 Feb 1	Ransburgh DJ	doi: 10.1158/0008-5472.CAN-09-2850
18703154	Interaction of p14ARF with Brca1 in cancer cell lines and primary breast cancer.	Cell Biol Int	2008 Oct	He L	doi: 10.1016/j.cellbi.2008.07.018
21099359	BRCA1 modulates the expression of hnRNPA2B1 and KHSRP.	Cell Cycle	2010 Dec 1	Santarosa M	-
22401979	Allelic transcripts dosage effect in morphologically normal ovarian cells from heterozygous carriers of a BRCA1/2 French Canadian founder mutation.	Cancer Prev Res (Phila)	2012 May	Abd-Rabbo D	doi: 10.1158/1940-6207.CAPR-11-0547
21194536	Evolutionary dynamics of BRCA1 alterations in breast tumorigenesis.	J Theor Biol	2011 Mar 21	De Vargas Roditi L	doi: 10.1016/j.jtbi.2010.12.033
15220350	Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.	J Biol Chem	2004 Aug 13	Xu X	-
21670155	Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter.	Mol Cell Biol	2011 Aug	Lu Y	doi: 10.1128/MCB.01121-10
15166217	Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression.	J Biol Chem	2004 Aug 6	Choudhury AD	-
25879355	Expression of BRCA1 and BRCA2 proteins and their correlation with clinical staging in breast cancer.	J Cancer Res Ther	2015 Jan-Mar	Hedau S	doi: 10.4103/0973-1482.140985.
21203981	The role of BRCA1 in DNA damage response.	Protein Cell	2010 Feb	Wu J	doi: 10.1007/s13238-010-0010-5.
20398395	Lympho-vascular invasion in BRCA related breast cancer compared to sporadic controls.	BMC Cancer	2010 Apr 16	Heerma van Voss MR	doi: 10.1186/1471-2407-10-145.
19649554	Breast-conserving surgery in BRCA1/2 mutation carriers: are we approaching an answer?	Ann Surg Oncol	2009 Dec	Garcia-Etienne CA	doi: 10.1245/s10434-009-0638-7.
17452776	655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations.	Cell Oncol	2007	Tommasi S	-
26867710	BRCA1 and BRCA2 Mutation Testing in Young Women With Breast Cancer.	JAMA Oncol	2016 Jun 1	Rosenberg SM	doi: 10.1001/jamaoncol.2015.5941.
17496925	A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation.	Oncogene	2007 Nov 8	Li W	-
20814958	Insights into the targeted elimination of BRCA1-defective cancer stem cells.	Med Res Rev	2012 Sep	Somasundaram V	doi: 10.1002/med.20229
24151232	BRCA1-mediated inflammation and growth activated & inhibited transition mechanisms between no-tumor hepatitis/cirrhotic tissues and HCC.	J Cell Biochem	2014 Apr	Diao H	doi: 10.1002/jcb.24699.
11983207	Expression of BRCA1 and BRCA2 in different tumor cell lines with various growth status.	Clin Chim Acta	2002 Jun	Vissac C	-
20345474	The contribution of founder mutations in BRCA1 to breast and ovarian cancer in Lithuania.	Clin Genet	2010 Oct	Elsakov P	doi: 10.1111/j.1399-0004.2010.01404.x.
25428789	Inherited predisposition to breast cancer among African American women.	Breast Cancer Res Treat	2015 Jan	Churpek JE	doi: 10.1007/s10549-014-3195-0
22511931	BRCA1-IRIS overexpression promotes formation of aggressive breast cancers.	PLoS One	2012	Shimizu Y	doi: 10.1371/journal.pone.0034102
22843497	Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer.	Hum Mol Genet	2012 Nov 1	Hansmann T	doi: 10.1093/hmg/dds308
27997688	Novel splice-switching oligonucleotide promotes BRCA1 aberrant splicing and susceptibility to PARP inhibitor action.	Int J Cancer	2017 Apr 1	Smith LD	doi: 10.1002/ijc.30574
26615718	Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice.	Radiother Oncol	2016 May	Bakr A	doi: 10.1016/j.radonc.2015.11.001
27193872	Knockdown of COUP-TFII inhibits cell proliferation and induces apoptosis through upregulating BRCA1 in renal cell carcinoma cells.	Int J Cancer	2016 Oct 1	Zheng J	doi: 10.1002/ijc.30193
28377179	Rapid selection of BRCA1-proficient tumor cells during neoadjuvant therapy for ovarian cancer in BRCA1 mutation carriers.	Cancer Lett	2017 Jul 1	Sokolenko AP	doi: 10.1016/j.canlet.2017.03.036
28549976	BRCA mutational status, initial disease presentation, and clinical outcome in high-grade serous advanced ovarian cancer: a multicenter study.	Am J Obstet Gynecol	2017 Sep	Petrillo M	doi: 10.1016/j.ajog.2017.05.036
28264838	Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.	Cancer Prev Res (Phila)	2017 Apr	Chiyoda T	doi: 10.1158/1940-6207.CAPR-16-0281
27167707	Detection of somatic BRCA1/2 mutations in ovarian cancer - next-generation sequencing analysis of 100 cases.	Cancer Med	2016 Jul	Koczkowska M	doi: 10.1002/cam4.748
28857155	Prevalent somatic BRCA1 mutations shape clinically relevant genomic patterns of nasopharyngeal carcinoma in Southeast Europe.	Int J Cancer	2018 Jan 1	Fountzilas G	doi: 10.1002/ijc.31023
28343309	Breast cancer detection and tumor characteristics in BRCA1 and BRCA2 mutation carriers.	Breast Cancer Res Treat	2017 Jun	Krammer J	doi: 10.1007/s10549-017-4198-4
27793035	Performance of multiplicom's BRCA MASTR Dx kit on the detection of BRCA1 and BRCA2 mutations in fresh frozen ovarian and breast tumor samples.	Oncotarget	2016 Dec 6	Badoer C	doi: 10.18632/oncotarget.12877.
28499366	The role of BRCA1-IRIS in the development and progression of triple negative breast cancers in Egypt: possible link to disease early lesion.	BMC Cancer	2017 May 12	Bogan D	doi: 10.1186/s12885-017-3283-8.
29860064	Expression analysis of the MCPH1/BRIT1 and BRCA1 tumor suppressor genes and telomerase splice variants in epithelial ovarian cancer.	Gene	2018 Sep 25	Alsiary R	doi: 10.1016/j.gene.2018.05.113
27845331	BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.	Nat Commun	2016 Nov 15	Rasmussen RD	doi: 10.1038/ncomms13398.
30049201	Methylation Profiles of BRCA1, RASSF1A and GSTP1 in Vietnamese Women with Breast Cancer	Asian Pac J Cancer Prev	2018 Jul 27	Vu TL	-
30315757	Additional molecular and clinical evidence open the way to definitive IARC classification of the BRCA1 c.5332G>A (p.Asp1778Asn) variant.	Clin Biochem	2019 Jan	Minucci A	doi: 10.1016/j.clinbiochem.2018.10.004
28680148	Prevalence and Penetrance of BRCA1 and BRCA2 Germline Mutations in Colombian Breast Cancer Patients.	Sci Rep	2017 Jul 5	Torres D	doi: 10.1038/s41598-017-05056-y.
25948675	BRCAPRO 6.0 Model Validation in Male Patients Presenting for BRCA Testing.	Oncologist	2015 Jun	Mitri ZI	doi: 10.1634/theoncologist.2014-0425
18241344	Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics.	Breast Cancer Res	2008	Wright MH	doi: 10.1186/bcr1855
22136207	Association of BRCA1 functional single nucleotide polymorphisms with risk of differentiated thyroid carcinoma.	Thyroid	2012 Jan	Xu L	doi: 10.1089/thy.2011.0117
16998791	Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients.	Int J Cancer	2006 Dec 15	Rashid MU	-
24519767	Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis.	BMJ	2014 Feb 11	Metcalfe K	doi: 10.1136/bmj.g226.
15936476	[Molecular alterations in breast cancer: clinical implications and new analytical tools].	Rev Med Interne	2005 Jun	Gonalves A	-
18030615	High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer.	Breast Cancer Res Treat	2008 Oct	van der Groep P	-
20077502	Cancer predisposing missense and protein truncating BARD1 mutations in non-BRCA1 or BRCA2 breast cancer families.	Hum Mutat	2010 Mar	De Brakeleer S	doi: 10.1002/humu.21200.
12440810	Risk factors for ovarian cancer and early-onset breast cancer in Mongolia.	Eur J Gynaecol Oncol	2002	Elit L	-
18355772	Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.	Am J Hum Genet	2008 Apr	Antoniou AC	doi: 10.1016/j.ajhg.2008.02.008
21799032	Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1-Interacting Genes.	Cancer Res	2011 Sep 1	Rebbeck TR	doi: 10.1158/0008-5472.CAN-11-0773
20204502	Penetrance of breast cancer, ovarian cancer and contralateral breast cancer in BRCA1 and BRCA2 families: high cancer incidence at older age.	Breast Cancer Res Treat	2010 Dec	van der Kolk DM	doi: 10.1007/s10549-010-0805-3
23050611	Is multiple SNP testing in BRCA2 and BRCA1 female carriers ready for use in clinical practice? Results from a large Genetic Centre in the UK.	Clin Genet	2013 Jul	Ingham SL	doi: 10.1111/cge.12035
25849179	Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.	JAMA	2015 Apr 7	Rebbeck TR	doi: 10.1001/jama.2014.5985.
25403427	The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females.	BMC Cancer	2014 Nov 17	Al-Moghrabi N	doi: 10.1186/1471-2407-14-830.
18312450	Probability of BRCA1/2 mutation varies with ovarian histology: results from screening 442 ovarian cancer families.	Clin Genet	2008 Apr	Evans DG	doi: 10.1111/j.1399-0004.2008.00974.x
23935836	Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases.	PLoS One	2013 Jul 23	Blanco A	doi: 10.1371/journal.pone.0067538
18098285	On the dynamics of breast tumor development in women carrying germline BRCA1 and BRCA2 mutations.	Int J Cancer	2008 Apr 15	Simon R	-
21410590	Mutational screening of the BRCA1 gene in sporadic breast cancer in Kazakhstan population.	Breast J	2011 May-Jun	Akilzhanova A	doi: 10.1111/j.1524-4741.2011.01068.x
17557253	[Analysis of the mutation of BRCA1 gene in 70 Uigur women breast cancer patients in Xinjiang].	Zhonghua Yi Xue Yi Chuan Xue Za Zhi	2007 Jun	Fu XG	-
23544013	Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.	PLoS Genet	2013	Couch FJ	doi: 10.1371/journal.pgen.1003212
22443199	Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers.	J Intern Med	2012 Apr	Barnes DR	doi: 10.1111/j.1365-2796.2011.02502.x.
26006218	Prospective multicenter cohort study of estrogen and insulin-like growth factor system in BRCA mutation carriers.	Cancer Causes Control	2015 Aug	Kim J	doi: 10.1007/s10552-015-0601-9
21221768	Risk of ipsilateral breast cancer in BRCA1 and BRCA2 mutation carriers.	Breast Cancer Res Treat	2011 May	Metcalfe K	doi: 10.1007/s10549-010-1336-7
20852631	A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.	Nat Genet	2010 Oct	Antoniou AC	doi: 10.1038/ng.669
21496870	Human epidermal growth factor receptor 2, Na+/H+ exchanger regulatory factor 1, and breast cancer susceptibility gene-1 as new biomarkers for familial breast cancers.	Hum Pathol	2011 Nov	Mangia A	doi: 10.1016/j.humpath.2011.01.010
20507347	The contribution of founder mutations in BRCA1 to breast cancer in Belarus.	Clin Genet	2010 Oct	Uglanitsa N	doi: 10.1111/j.1399-0004.2010.01439.x.
17987791	Germline BRCA1 mutation and survival analysis in familial breast cancer patients in Kerala; South India.	J Exp Clin Cancer Res	2007 Sep	Vinodkumar B	-
16271956	Search for large genomic alterations of the BRCA1 gene in a Finnish population.	Cancer Genet Cytogenet	2005 Nov	Laurila E	-
21598239	Prevalence of BRCA1 and BRCA2 mutations in Ashkenazi Jewish families with breast and pancreatic cancer.	Cancer	2012 Jan 15	Stadler ZK	doi: 10.1002/cncr.26191
18835712	Mutation screening of the BRCA1 gene in sporadic breast cancer in southern Chinese populations.	Breast	2008 Dec	Haitian Z	doi: 10.1016/j.breast.2008.08.003
22729394	A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers.	Cancer Epidemiol Biomarkers Prev	2012 Aug	Ding YC	-
12677558	Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies.	Am J Hum Genet	2003 May	Antoniou A	-
18971141	Occult fallopian tube cancer in a patient with BRCA1 breast cancer.	J Minim Invasive Gynecol	2008 Nov-Dec	Brown JV 3rd	doi: 10.1016/j.jmig.2008.07.007.
21324516	Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer.	Gynecol Oncol	2011 May 1	Zhang S	doi: 10.1016/j.ygyno.2011.01.020
12872263	Founder mutation in the BRCA1 gene in Malay breast cancer patients from Singapore.	Hum Mutat	2003 Aug	Lee AS	-
20472656	BRCA1, BRCA2 and CHEK2 c.1100 delC mutations in patients with double primaries of the breasts and/or ovaries.	J Med Genet	2010 Aug	Evans DG	doi: 10.1136/jmg.2009.075770
15345109	BRCA1 mutations in a population-based study of breast cancer in Stockholm County.	Genet Test	2004 Summer	Margolin S	-
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19268590	PALB2 links BRCA1 and BRCA2 in the DNA-damage response.	Curr Biol	2009 Mar 24	Zhang F	doi: 10.1016/j.cub.2009.02.018
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