EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27456359Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.Tumour Biol2016 OctStarska K-
19946330Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer.Oncogene2010 Mar 4Kulkarni Sdoi: 10.1038/onc.2009.422
24691096Proteolysis of the human DNA polymerase delta smallest subunit p12 by ??-calpain in calcium-triggered apoptotic HeLa cells.PLoS One2014 Apr 1Fan Xdoi: 10.1371/journal.pone.0093642
12393869The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells.J Biol Chem2003 Jan 10Rios-Doria J-
21305563Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss.Muscle Nerve2011 MarSmith IJdoi: 10.1002/mus.21893
18726991Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells.J Cell Physiol2008 DecYang Hdoi: 10.1002/jcp.21565.
26496999Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study.Histopathology2016 JunPu Xdoi: 10.1111/his.12896
28498452Calpain and AR-V7: Two potential therapeutic targets to overcome acquired docetaxel resistance in castration-resistant prostate cancer cells.Oncol Rep2017 JunLiu Ldoi: 10.3892/or.2017.5623
28536704Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the Proliferative/Apoptotic Index.Biomed Res Int2017Al-Bahlani SMdoi: 10.1155/2017/9290425

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1165210059Missense_MutationnovelM635I0.15
BLCAchr1165204783SilentNAA422A0.31
BLCAchr11652139513'Flanknovel0.14
BLCAchr11652140543'Flanknovel0.35
BLCAchr11652140473'Flanknovel0.65
BLCAchr1165204856Missense_MutationNAE447Q0.63
BLCAchr1165183508SilentnovelL124L0.21
BLCAchr11652142443'FlankNA0.2
BLCAchr1165210833SilentnovelD693D0.04
BLCAchr1165183487SilentnovelL117L0.16
BLCAchr1165182932SilentnovelS77S0.38
BLCAchr1165210385Silentrs747653455S664S0.31
BRCAchr1165210833Missense_MutationNAD693E0.27
BRCAchr11652113413'UTRnovel0.37
BRCAchr1165206516Silentrs745365536A469A0.61
BRCAchr11652139303'FlankNA0.41
BRCAchr1165206526Missense_Mutationrs762252249R473C0.26
BRCAchr1165185951Missense_MutationNAV164A0.29
BRCAchr1165206553Missense_MutationnovelE482K0.22
BRCAchr1165206636Silentrs559519689F509F0.09
BRCAchr1165204821Missense_MutationNAG435D0.31
BRCAchr11652112983'UTRrs5323482090.11
BRCAchr1165186174Missense_MutationNAN199H0.81
CESCchr11651809925'FlankNA0.42
CESCchr1165186261Frame_Shift_InsnovelR228Pfs*270.12
CESCchr1165187279Missense_MutationNAS275C0.5
CESCchr1165188691SilentNAL370L0.48
CESCchr1165206570Missense_MutationNAF487L0.41
CESCchr11651809265'Flanknovel0.44
CESCchr1165204807SilentnovelR430R0.37
CESCchr11652140613'Flankrs3702458410.31
CESCchr1165182828Missense_MutationNAE43Q0.23
CESCchr1165188616SilentnovelF345F0.27
CESCchr1165182914SilentNAK71K0.21
CESCchr1165206790Missense_MutationnovelD526N0.5
CHOLchr1165182808Missense_MutationnovelK36T0.53
COADchr1165204819SilentNAF434F0.3
COADchr1165209358Missense_MutationnovelS589P0.12
COADchr1165186262Missense_Mutationrs748491783R228H0.2
COADchr1165209364Missense_Mutationrs750102134R591C0.18
COADchr1165206516Silentrs745365536A469A0.55
COADchr1165204728Missense_Mutationrs769161725T404M0.52
COADchr1165183134SilentnovelL92L0.2
COADchr11652141813'Flankrs3683504910.22
COADchr1165186255Missense_MutationnovelE226K0.14
COADchr11652113283'UTRrs3770119220.24
COADchr11652140103'Flankrs7817369570.37
COADchr1165210056SilentNAS634S0.2
ESCAchr1165186252Missense_MutationnovelY225H0.38
ESCAchr11652140583'Flanknovel0.16
ESCAchr11652140093'FlankNA0.15
ESCAchr11651810285'Flanknovel0.62
ESCAchr11652114523'UTRnovel0.41
ESCAchr11652141833'Flanknovel0.05
GBMchr1165183179Missense_MutationNAI107V0.34
GBMchr1165206490Missense_MutationnovelK461Q0.42
GBMchr1165186262Missense_Mutationrs748491783R228H0.23
GBMchr1165206509Missense_MutationnovelA467V0.14
HNSCchr1165206489Missense_MutationnovelL460F0.07
HNSCchr1165210855Missense_MutationnovelT701A0.32
HNSCchr1165211285Silentnovel*715*0.38
KIRCchr1165204785Frame_Shift_DelnovelL423Pfs*390.27
KIRPchr1165206647Missense_MutationNAF513C0.23
LGGchr11652139453'Flanknovel0.19
LUADchr11652143863'Flanknovel0.15
LUADchr1165188583Splice_Regionnovel0.19
LUADchr1165186268Missense_MutationnovelA230V0.42
LUADchr1165206653Missense_MutationNAS515L0.18
LUADchr1165206570SilentnovelF487F0.32
LUADchr11652140053'Flanknovel0.31
LUSCchr1165188668Missense_MutationnovelI363F0.21
LUSCchr1165210386Missense_MutationNAE665K0.14
LUSCchr1165204824Missense_MutationNAR436L0.85
LUSCchr1165188655SilentnovelL358L0.1
LUSCchr1165186293SilentnovelI238I0.29
MESOchr11651808915'Flanknovel0.08
OVchr1165210072Missense_MutationnovelM640L0.45
OVchr1165206606SilentnovelS499S0.14
PAADchr1165204781Missense_MutationNAA422T0.22
PRADchr1165206644Missense_Mutationrs756980532R512H0.37
READchr1165187223Silentrs534960869S256S0.34
READchr11652140103'Flankrs7817369570.26
READchr11652144303'Flankrs3680142250.19
READchr1165210849Missense_MutationnovelV699F0.07
SARCchr11652140713'Flanknovel0.07
SKCMchr11652140123'FlankNA0.25
SKCMchr11652141693'FlankNA0.6
SKCMchr1165188670SilentNAI363I0.42
SKCMchr11652112933'UTRrs7790717960.58
SKCMchr1165209359Missense_Mutationrs761412242S589L0.29
SKCMchr1165210344Missense_MutationnovelL651F0.5
SKCMchr1165206673Missense_MutationNAV522M0.18
SKCMchr11652143533'FlankNA0.35
SKCMchr1165204802Missense_Mutationrs777787068R429C0.14
SKCMchr1165183564Missense_MutationNAN143I0.22
STADchr1165210403SilentnovelV670V0.29
STADchr11652140103'Flankrs7817369570.45
STADchr1165204819SilentNAF434F0.29
STADchr11652139633'Flankrs7799558180.29
STADchr1165204800Missense_MutationNAR428H0.3
STADchr1165204800Missense_MutationNAR428H0.43
STADchr1165185991Silentrs200853785F177F0.21
STADchr1165183176Missense_MutationnovelD106N0.08
STADchr1165204781Missense_MutationNAA422T0.36
STADchr1165206551Missense_Mutationrs763471308R481Q0.29
STADchr1165206526Missense_Mutationrs762252249R473C0.23
STADchr1165210400Silentrs377531394A669A0.45
STADchr11652143673'Flankrs3708452480.27
STADchr1165209879Missense_MutationNAE609K0.21
STADchr1165206516Silentrs745365536A469A0.04
STADchr1165210403SilentnovelV670V0.17
STADchr1165182737SilentnovelT12T0.38
STADchr11652113423'UTRnovel0.29
TGCTchr1165188680Frame_Shift_InsnovelL370Hfs*360.14
THCAchr11652143413'Flanknovel0.28
THYMchr11651813115'Flanknovel0.08
UCECchr1165206515Missense_MutationNAA469V0.13
UCECchr1165210861Missense_MutationnovelD703Y0.1
UCECchr1165188029SilentnovelA306A0.41
UCECchr1165183187Missense_MutationnovelQ109H0.36
UCECchr1165206598Missense_MutationnovelV497M0.2
UCECchr1165206572Missense_Mutationrs376981701R488H0.21
UCECchr11651806935'Flanknovel0.43
UCECchr11652140263'Flankrs3728323520.39
UCECchr1165187240Missense_Mutationrs192099450A262D0.23
UCECchr1165188460SilentnovelR326R0.05
UCECchr1165206515Missense_MutationNAA469V0.1
UCECchr1165209907Missense_Mutationrs772985471R618Q0.41
UCECchr1165182830Missense_MutationnovelE43D0.09
UCECchr1165185943Silentrs17881255D161D0.3
UCECchr1165206630Silentrs761219620G507G0.16
UCECchr1165210418SilentNAF675F0.05
UCECchr11652139223'Flankrs7654899780.41
UCECchr1165185976Silentrs200819735D172D0.18
UCECchr1165210448Missense_MutationnovelM685I0.16
UCECchr11652142513'Flanknovel0.22
UCECchr11652141833'Flankrs7639917650.39
UCECchr1165185991Silentrs200853785F177F0.56
UCECchr1165188710Missense_Mutationrs369163523R377W0.62
UCECchr1165209365Missense_Mutationrs190935218R591H0.45
UCECchr11651808655'Flanknovel0.69
UCECchr11652140103'Flankrs7817369570.33
UCECchr1165208204Splice_SitenovelX558_splice0.28
UCECchr11651806525'Flanknovel0.29
UCECchr11652141693'Flanknovel0.05
UCECchr11652142223'Flankrs5676224310.34
UCECchr1165206813Silentrs771495649P533P0.48
UCECchr1165210049Missense_Mutationrs770520025S632L0.35
UCECchr11652138773'Flankrs5431805590.31
UCECchr1165188022Missense_Mutationrs377052700T304M0.15
UCECchr1165210092Silentrs756358689S646S0.2
UCECchr11651808735'Flanknovel0.46
UCECchr11652143533'Flanknovel0.5
UCECchr1165182824Missense_MutationnovelD41E0.34
UCECchr11652140153'FlankNA0.37
UCECchr1165188735Missense_MutationNAR385Q0.49
UCECchr1165182907Missense_MutationnovelG69D0.44
UCECchr11651812525'Flanknovel0.24
UCECchr1165204846SilentnovelF443F0.28
UCECchr1165206520Missense_Mutationrs775100954R471W0.24
UCECchr11652140563'Flanknovel0.16
UCECchr1165210418SilentNAF675F0.54
UCECchr11651808825'Flanknovel0.44
UCECchr1165185976Silentrs200819735D172D0.32
UCECchr11651812385'Flanknovel0.62
UCECchr1165206636Silentrs559519689F509F0.44
UCECchr1165206515Missense_MutationNAA469V0.35
UCECchr11652113513'UTRnovel0.49
UCECchr1165204830Missense_MutationnovelM438T0.27
UCECchr1165182876Nonsense_MutationnovelE59*0.16
UCECchr1165185991Silentrs200853785F177F0.53
UCECchr1165186321SilentnovelL248L0.21
UCECchr1165188669Missense_MutationnovelI363T0.29
UCECchr11652140103'Flankrs7817369570.32
UCECchr1165182756Nonsense_MutationnovelQ19*0.25
UCECchr1165186309Missense_Mutationrs759801167R244W0.38
UCECchr1165206493Missense_Mutationrs758232757R462C0.41
UCECchr11652139193'Flanknovel0.48
UCECchr11652142273'Flankrs7733570460.35
UCECchr1165183538SilentnovelV134V0.37
UCECchr1165210056SilentNAS634S0.5

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.16941.2183e-05
ESCAAMP0.2120.018342
TGCTDEL0.70.21504

Survival Analysis
CancerP-value Q-value
THYM0.0037

Kaplan-Meier Survival Analysis

KIRC0.00088

Kaplan-Meier Survival Analysis

STAD0.012

Kaplan-Meier Survival Analysis

SARC0.0008

Kaplan-Meier Survival Analysis

ACC0.026

Kaplan-Meier Survival Analysis

SKCM0.016

Kaplan-Meier Survival Analysis

KIRP0.00055

Kaplan-Meier Survival Analysis

PAAD0.00053

Kaplan-Meier Survival Analysis

LAML0.00011

Kaplan-Meier Survival Analysis

GBM0.0056

Kaplan-Meier Survival Analysis

LIHC0.0055

Kaplan-Meier Survival Analysis

LGG0.00013

Kaplan-Meier Survival Analysis

OV0.047

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000014216 (Gene tree)
Gene ID
823
Gene Symbol
CAPN1
Alias
muCANP|muCL|CANP|CANPL1
Full Name
calpain 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
31,441 bases
Position
chr11:65,180,566-65,212,006
Accession
1476
RBP type
non-canonical RBP
Summary
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30508278Characterizations of HSP90-Interacting Complex in Renal Cells Using Tandem Affinity Purification and Its Potential Role in Kidney Stone Formation.Proteomics2018 DecManissorn Jdoi: 10.1002/pmic.201800004.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000526966CAPN1-206550-ENSP00000431528161 (aa)-E9PJA6
ENST00000529133CAPN1-217593-ENSP00000432512191 (aa)-E9PQB3
ENST00000524773CAPN1-2022960-ENSP00000434176714 (aa)-P07384
ENST00000527887CAPN1-212348--- (aa)--
ENST00000530495CAPN1-219572--- (aa)--
ENST00000533909CAPN1-227573-ENSP00000435198148 (aa)-E9PLC9
ENST00000533820CAPN1-2263083-ENSP00000435272714 (aa)-P07384
ENST00000526468CAPN1-204690-ENSP00000433366191 (aa)-E9PL37
ENST00000528739CAPN1-216341--- (aa)--
ENST00000528165CAPN1-2142828--- (aa)--
ENST00000527469CAPN1-209584--- (aa)--
ENST00000527739CAPN1-211582-ENSP00000433823161 (aa)-E9PJA6
ENST00000279247CAPN1-2013007-ENSP00000279247714 (aa)-P07384
ENST00000533129CAPN1-2242792XM_006718698ENSP00000431686714 (aa)XP_006718761P07384
ENST00000525013CAPN1-203643--- (aa)--
ENST00000526954CAPN1-205754-ENSP00000436002201 (aa)-E9PRM1
ENST00000530567CAPN1-2201415--- (aa)--
ENST00000530442CAPN1-218577--- (aa)--
ENST00000534373CAPN1-228581-ENSP00000431793135 (aa)-E9PJJ3
ENST00000527323CAPN1-2083086XM_011545292ENSP00000431984714 (aa)XP_011543594P07384
ENST00000528396CAPN1-215571-ENSP00000435847163 (aa)-E9PSA6
ENST00000532285CAPN1-222568-ENSP0000043669363 (aa)-E9PIA9
ENST00000527897CAPN1-213879--- (aa)--
ENST00000527189CAPN1-207558--- (aa)--
ENST00000533079CAPN1-223878--- (aa)--
ENST00000533704CAPN1-225643--- (aa)--
ENST00000527699CAPN1-210564-ENSP00000431172152 (aa)-E9PMC6
ENST00000531068CAPN1-221496-ENSP00000435092122 (aa)-E9PLX0
Gene Model
Click here to download ENSG00000014216's gene model file
Pathways
Pathway IDPathway NameSource
hsa04141Protein processing in endoplasmic reticulumKEGG
hsa04210ApoptosisKEGG
hsa04217NecroptosisKEGG
hsa04218Cellular senescenceKEGG
hsa05010Alzheimer diseaseKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000014216's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004198calcium-dependent cysteine-type endopeptidase activity21873635.IBAFunction
GO:0004198calcium-dependent cysteine-type endopeptidase activity2407243.16411745.IDAFunction
GO:0004198calcium-dependent cysteine-type endopeptidase activity-ISSFunction
GO:0004198calcium-dependent cysteine-type endopeptidase activity17526495.TASFunction
GO:0005509calcium ion binding9271093.IDAFunction
GO:0005515protein binding9407132.19712109.21988832.22805611.IPIFunction
GO:0005576extracellular region-TASComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005739mitochondrion-IEAComponent
GO:0005764lysosome-IEAComponent
GO:0005829cytosol8769305.12150984.14559243.21531719.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane8769305.12150984.IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0006508proteolysis21873635.IBAProcess
GO:0006508proteolysis2400579.2407243.16411745.21531719.IDAProcess
GO:0006508proteolysis-ISSProcess
GO:0008284positive regulation of cell proliferation8702541.TASProcess
GO:0016020membrane14559243.IDAComponent
GO:0016241regulation of macroautophagy17264674.NASProcess
GO:0022617extracellular matrix disassembly-TASProcess
GO:0032801receptor catabolic process-IEAProcess
GO:0043312neutrophil degranulation-TASProcess
GO:0050790regulation of catalytic activity8954105.9271093.IDAProcess
GO:0060056mammary gland involution-IEAProcess
GO:0070062extracellular exosome19056867.19199708.23533145.HDAComponent
GO:0070268cornification-TASProcess
GO:0097264self proteolysis8769305.8954105.IDAProcess
GO:1904813ficolin-1-rich granule lumen-TASComponent
GO:2000310regulation of NMDA receptor activity17526495.TASProcess
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