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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22421353Slug contributes to cadherin switch and malignant progression in muscle-invasive bladder cancer development.Urol Oncol2013 NovWu Kdoi: 10.1016/j.urolonc.2012.02.001
23634282Slug increases sensitivity to tubulin-binding agents via the downregulation of βIII and βIVa-tubulin in lung cancer cells.Cancer Med2013 AprTamura Ddoi: 10.1002/cam4.68
24100634ETV1 induces epithelial to mesenchymal transition in human gastric cancer cells through the upregulation of Snail expression.Oncol Rep2013 DecLi Zdoi: 10.3892/or.2013.2776
27748910MicroRNA-124 inhibits cell proliferation and migration by regulating SNAI2 in breast cancer.Oncol Rep2016 DecDu Sdoi: 10.3892/or.2016.5163
28215642CCL2 expression correlates with Snail expression and affects the prognosis of patients with gastric cancer.Pathol Res Pract2017 MarZhang Jdoi: 10.1016/j.prp.2016.12.013
29989579[Inhibition of Histone Deacetylases Reverses Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells through a Slug Mediated Mechanism].Mol Biol (Mosk)2018 May-JunRahimian Adoi: 10.7868/S0026898418030102.
26194471Relationship between circulating tumor cells and epithelial to mesenchymal transition in early breast cancer.BMC Cancer2015 Jul 22Mego Mdoi: 10.1186/s12885-015-1548-7.
27368877Slug Is Associated With Tumor Metastasis and Angiogenesis in Ovarian Cancer.Reprod Sci2017 FebGu Adoi: 10.1177/1933719116654989
24549638BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2.Stem Cells2014 MarRichter Adoi: 10.1002/stem.1592.
21274735Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer.Gastric Cancer2011 MarUchikado Ydoi: 10.1007/s10120-011-0004-x
25982283IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG.Oncogene2016 Mar 3Samanta Sdoi: 10.1038/onc.2015.164
21808237Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis.Lab Invest2011 OctMikami Sdoi: 10.1038/labinvest.2011.111
20622260Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin.J Biol Chem2010 Sep 17Tanno Bdoi: 10.1074/jbc.M109.089045
21053100Short interfering RNA directed against Slug blocks tumor growth, metastasis formation, and vascular leakage in bladder cancer.Med Oncol2011 DecWang Xdoi: 10.1007/s12032-010-9728-4
23352643Snail2 promotes osteosarcoma cell motility through remodelling of the actin cytoskeleton and regulates tumor development.Cancer Lett2013 Jun 10Sharili ASdoi: 10.1016/j.canlet.2013.01.027
24233839Gas6/Axl pathway promotes tumor invasion through the transcriptional activation of Slug in hepatocellular carcinoma.Carcinogenesis2014 AprLee HJdoi: 10.1093/carcin/bgt372
22911700The epithelial-mesenchymal transition (EMT) regulatory factor SLUG (SNAI2) is a downstream target of SPARC and AKT in promoting melanoma cell invasion.PLoS One2012Fenouille Ndoi: 10.1371/journal.pone.0040378
23447531Signaling between transforming growth factor β (TGF-β) and transcription factor SNAI2 represses expression of microRNA miR-203 to promote epithelial-mesenchymal transition and tumor metastasis.J Biol Chem2013 Apr 12Ding Xdoi: 10.1074/jbc.M112.443655
21199805Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis.Cancer Res2011 Jan 1Casas Edoi: 10.1158/0008-5472.CAN-10-2330.
21120639Slug inhibition upregulates radiation-induced PUMA activity leading to apoptosis in cholangiocarcinomas.Med Oncol2011 DecZhang Kdoi: 10.1007/s12032-010-9759-x
25652255Slug contributes to cancer progression by direct regulation of ERα signaling pathway.Int J Oncol2015 AprLi Ydoi: 10.3892/ijo.2015.2878
21081648IKK(α) controls canonical TGF()-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells.J Cell Sci2010 Dec 15Brandl Mdoi: 10.1242/jcs.071100
25337226Slug is associated with poor survival in squamous cell carcinoma of the lung.Int J Clin Exp Pathol2014 Aug 15Merikallio H-
25317798ERK5 silencing inhibits invasion of human osteosarcoma cell via modulating the Slug/MMP-9 pathway.Eur Rev Med Pharmacol Sci2014Yue B-
24984960Axl mediates tumor invasion and chemosensitivity through PI3K/Akt signaling pathway and is transcriptionally regulated by slug in breast carcinoma.IUBMB Life2014 JulLi Ydoi: 10.1002/iub.1285
22937066Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression.PLoS One2012Lin ZSdoi: 10.1371/journal.pone.0043593
23438693Mdm2 increases cellular invasiveness by binding to and stabilizing the Slug mRNA.Cancer Lett2013 Jul 28Jung CHdoi: 10.1016/j.canlet.2013.02.035
17984306Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.J Exp Med2007 Nov 26Leong KG-
27760172Inhibition of Snail Family Transcriptional Repressor 2 (SNAI2) Enhances Multidrug Resistance of Hepatocellular Carcinoma Cells.PLoS One2016 Oct 19Zhao XYdoi: 10.1371/journal.pone.0164752
29436661Transdifferentiation of type II alveolar epithelial cells induces reactivation of dormant tumor cells by enhancing TGF-β1/SNAI2 signaling.Oncol Rep2018 AprZhou Ydoi: 10.3892/or.2018.6247
29921289SNAI2 upregulation is associated with an aggressive phenotype in fulvestrant-resistant breast cancer cells and is an indicator of poor response to endocrine therapy in estrogen receptor-positive metastatic breast cancer.Breast Cancer Res2018 Jun 19Alves CLdoi: 10.1186/s13058-018-0988-9.
25151968hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness.Oncogene2015 JunChoi MJdoi: 10.1038/onc.2014.270
26840943IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer.Stem Cells2016 AprYao Cdoi: 10.1002/stem.2320
22232555Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins.J Biol Chem2012 Feb 24Shields MAdoi: 10.1074/jbc.M111.308940
22208948Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo.BMC Cancer2011 Dec 30Anastassiou Ddoi: 10.1186/1471-2407-11-529.
28705116Alex3 suppresses non-small cell lung cancer invasion via AKT/Slug/E-cadherin pathway.Tumour Biol2017 JulDu Jdoi: 10.1177/1010428317701441.
28192397Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling.Oncogene2017 May 4Shi ZMdoi: 10.1038/onc.2016.414
27223436Lnc-CC3 increases metastasis in cervical cancer by increasing Slug expression.Oncotarget2016 Jul 5Jiang Bdoi: 10.18632/oncotarget.9519.
28974196Evaluation of Slug expression is useful for predicting lymph node metastasis and survival in patients with gastric cancer.BMC Cancer2017 Oct 3Lee HHdoi: 10.1186/s12885-017-3668-8.
29803676USP10 regulates the stability of the EMT-transcription factor Slug/SNAI2.Biochem Biophys Res Commun2018 Aug 25Ouchida ATdoi: 10.1016/j.bbrc.2018.05.156
28940639SPOCK1 promotes the invasion and metastasis of gastric cancer through Slug-induced epithelial-mesenchymal transition.J Cell Mol Med2018 FebChen Ddoi: 10.1111/jcmm.13357
23059759A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.Cancer Lett2013 Jan 28Li Zdoi: 10.1016/j.canlet.2012.09.026
23086238Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2.Nat Cell Biol2012 NovChakrabarti Rdoi: 10.1038/ncb2607
23567973Gas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug.Biochem Biophys Res Commun2013 Apr 26Lee Ydoi: 10.1016/j.bbrc.2013.03.082
16717446SLUG (SNAI2) overexpression in embryonic development.Cytogenet Genome Res2006Pérez-Mancera PA-
24403312hRAD9 functions as a tumor suppressor by inducing p21-dependent senescence and suppressing epithelial-mesenchymal transition through inhibition of Slug transcription.Carcinogenesis2014 JulWen FCdoi: 10.1093/carcin/bgu009
21470622Slug expression enhances tumor formation in a noninvasive rectal cancer model.J Surg Res2011 SepCamp ERdoi: 10.1016/j.jss.2011.02.012
23856032FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer.Cancer Lett2013 Oct 28Yang Cdoi: 10.1016/j.canlet.2013.07.004
25784376Helicobacter pylori-induced epithelial-mesenchymal transition, a potential role of gastric cancer initiation and an emergence of stem cells.Carcinogenesis2015 MayChoi YJdoi: 10.1093/carcin/bgv022
23031797Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cells.BMC Cancer2012 Oct 2Lambertini Edoi: 10.1186/1471-2407-12-445.
22496452High motility of triple-negative breast cancer cells is due to repression of plakoglobin gene by metastasis modulator protein SLUG.J Biol Chem2012 Jun 1Bailey CKdoi: 10.1074/jbc.M112.345728
24469056Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells.Oncogene2015 Jan 29Carpenter RLdoi: 10.1038/onc.2013.582
11912130The SLUG zinc-finger protein represses E-cadherin in breast cancer.Cancer Res2002 Mar 15Hajra KM-
22385965Slug and Sox9 cooperatively determine the mammary stem cell state.Cell2012 Mar 2Guo Wdoi: 10.1016/j.cell.2012.02.008.
27012210Curcumin suppresses 4-hydroxytamoxifen resistance in breast cancer cells by targeting SLUG/Hexokinase 2 pathway.Biochem Biophys Res Commun2016 Apr 22Geng Cdoi: 10.1016/j.bbrc.2016.03.067
26561320Is HNF4A a candidate to study zinc finger protein slug?Int J Bioinform Res Appl2015Suravajhala P-
22074556SLUG promotes prostate cancer cell migration and invasion via CXCR4/CXCL12 axis.Mol Cancer2011 Nov 10Uygur Bdoi: 10.1186/1476-4598-10-139.
16169465The transcriptional repressor Snail promotes mammary tumor recurrence.Cancer Cell2005 SepMoody SE-
23244088Lentivirus-mediated shRNA interference targeting SLUG inhibits lung cancer growth and metastasis.Asian Pac J Cancer Prev2012Wang YP-
22471696Snail is an independent prognostic predictor for progression and patient survival of gastric cancer.Cancer Sci2012 JulHe Hdoi: 10.1111/j.1349-7006.2012.02295.x
25707493The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer.Ann Surg Oncol2015 DecSakimura Sdoi: 10.1245/s10434-015-4418-2
24662746Activated androgen receptor promotes bladder cancer metastasis via Slug mediated epithelial-mesenchymal transition.Cancer Lett2014 Jun 28Jing Ydoi: 10.1016/j.canlet.2014.03.018
27165081Regulatory Proteins of Epithelial-Mesenchymal Transition and Some Components of VEGF Signaling Pathway in Breast Cancer.Bull Exp Biol Med2016 AprScherbakov AMdoi: 10.1007/s10517-016-3314-5
25728608SLUG is a direct transcriptional repressor of PTEN tumor suppressor.Prostate2015 Jun 15Uygur Bdoi: 10.1002/pros.22974
23996472Slug expression inhibits calcitriol-mediated sensitivity to radiation in colorectal cancer.Mol Carcinog2014 FebFindlay VJdoi: 10.1002/mc.22054
27495232Quercetin modulates Wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastases.Tumour Biol2016 OctBaruah MM-
23900394Knockdown of Slug by RNAi inhibits the proliferation and invasion of HCT116 colorectal cancer cells.Mol Med Rep2013 OctQian Jdoi: 10.3892/mmr.2013.1604
20101232ERalpha signaling through slug regulates E-cadherin and EMT.Oncogene2010 Mar 11Ye Ydoi: 10.1038/onc.2009.433
16541421Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.Prostate2006 Jun 15Chen M-
2617006711β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancer.Mol Cell Endocrinol2015 Sep 15Yoda Tdoi: 10.1016/j.mce.2015.07.008
25944620HOXB13 and ALX4 induce SLUG expression for the promotion of EMT and cell invasion in ovarian cancer cells.Oncotarget2015 May 30Yuan H-
23856093VAV1 represses E-cadherin expression through the transactivation of Snail and Slug: a potential mechanism for aberrant epithelial to mesenchymal transition in human epithelial ovarian cancer.Transl Res2013 SepWakahashi Sdoi: 10.1016/j.trsl.2013.06.005
19502595Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer.Carcinogenesis2009 AugLarriba MJdoi: 10.1093/carcin/bgp140
25728945Over-expression of lipocalin 2 promotes cell migration and invasion through activating ERK signaling to increase SLUG expression in prostate cancer.Prostate2015 Jun 15Ding Gdoi: 10.1002/pros.22978
24001454Increased expression of Slug and Vimentin as novel predictive biomarkers for lymph node metastasis and poor prognosis in colorectal cancer.Carcinogenesis2013 NovToiyama Ydoi: 10.1093/carcin/bgt282
26482776The role of MALAT1/miR-1/slug axis on radioresistance in nasopharyngeal carcinoma.Tumour Biol2016 MarJin Cdoi: 10.1007/s13277-015-4227-z
20564361Slug inhibits proliferation of human prostate cancer cells via downregulation of cyclin D1 expression.Prostate2010 Dec 1Liu Jdoi: 10.1002/pros.21213.
22886823Dysregulated expression of Slug, vimentin, and E-cadherin correlates with poor clinical outcome in patients with basal-like breast cancer.J Surg Oncol2013 FebLiu Tdoi: 10.1002/jso.23240
23815612Slug promoted vasculogenic mimicry in hepatocellular carcinoma.J Cell Mol Med2013 AugSun Ddoi: 10.1111/jcmm.12087
25645291Notch1 signaling regulates the epithelial-mesenchymal transition and invasion of breast cancer in a Slug-dependent manner.Mol Cancer2015 Feb 3Shao Sdoi: 10.1186/s12943-015-0295-3.
20509143TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype.J Cell Physiol2010 NovStorci Gdoi: 10.1002/jcp.22264.
18160708Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2.Mol Cell Biol2008 MarLaffin B-
19448627p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug.Nat Cell Biol2009 JunWang SPdoi: 10.1038/ncb1875
23410973Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer.Cancer Cell2013 Feb 11Yang Ddoi: 10.1016/j.ccr.2012.12.020.
25599843Evaluation of aldehyde dehydrogenase 1 and transcription factors in both primary breast cancer and axillary lymph node metastases as a prognostic factor.Breast Cancer2016 MayIto Mdoi: 10.1007/s12282-015-0583-1
19046938Tumor-induced upregulation of Twist, Snail, and Slug represses the activity of the human VE-cadherin promoter.Arch Biochem Biophys2009 FebLopez Ddoi: 10.1016/j.abb.2008.11.016
24662826Slug is temporally regulated by cyclin E in cell cycle and controls genome stability.Oncogene2015 Feb 26Wang WLdoi: 10.1038/onc.2014.58
26700673miR-497 inhibits epithelial mesenchymal transition in breast carcinoma by targeting Slug.Tumour Biol2016 JunWu Zdoi: 10.1007/s13277-015-4665-7
24036252Slug/β-catenin-dependent proinflammatory phenotype in hypoxic breast cancer stem cells.Am J Pathol2013 NovStorci Gdoi: 10.1016/j.ajpath.2013.07.020
23434592Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility.J Clin Invest2013 MarKuo TCdoi: 10.1172/JCI64044
23142026MicroRNA-1 targets Slug and endows lung cancer A549 cells with epithelial and anti-tumorigenic properties.Exp Cell Res2013 Feb 1Tominaga Edoi: 10.1016/j.yexcr.2012.10.015
26764010Proteomic Analysis of Epithelial to Mesenchymal Transition (EMT) Reveals Cross-talk between SNAIL and HDAC1 Proteins in Breast Cancer Cells.Mol Cell Proteomics2016 MarPalma Cde Sdoi: 10.1074/mcp.M115.052910
25997702Slug contributes to gemcitabine resistance through epithelial-mesenchymal transition in CD133(+) pancreatic cancer cells.Hum Cell2015 OctTsukasa Kdoi: 10.1007/s13577-015-0117-3
24721839C-kit induces epithelial-mesenchymal transition and contributes to salivary adenoid cystic cancer progression.Oncotarget2014 Mar 30Tang YL-
20138990The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression.J Steroid Biochem Mol Biol2010 JulLarriba MJdoi: 10.1016/j.jsbmb.2010.01.014
22974478Snail promotes lymph node metastasis and Twist enhances tumor deposit formation through epithelial-mesenchymal transition in colorectal cancer.Hum Pathol2013 FebFan XJdoi: 10.1016/j.humpath.2012.03.029
26387547SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma.Oncogene2016 Jun 2Luanpitpong Sdoi: 10.1038/onc.2015.351
28334049MMP1 expression is activated by Slug and enhances multi-drug resistance (MDR) in breast cancer.PLoS One2017 Mar 23Shen CJdoi: 10.1371/journal.pone.0174487
27524413RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin.Oncogene2017 Feb 23Hwang MHdoi: 10.1038/onc.2016.277
28610956Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2C.Cancer Lett2017 Aug 28Chang THdoi: 10.1016/j.canlet.2017.06.002
28574664Chemokine (CC motif) ligand 18 upregulates Slug expression to promote stem-cell like features by activating the mammalian target of rapamycin pathway in oral squamous cell carcinoma.Cancer Sci2017 AugWang Hdoi: 10.1111/cas.13289
27878953Long non-coding RNA linc00261 suppresses gastric cancer progression via promoting Slug degradation.J Cell Mol Med2017 MayYu Ydoi: 10.1111/jcmm.13035
28504716VEGFA links self-renewal and metastasis by inducing Sox2 to repress miR-452, driving Slug.Oncogene2017 Sep 7Kim Mdoi: 10.1038/onc.2017.4
27783945The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer.Cell Rep2016 Oct 25Zhou Wdoi: 10.1016/j.celrep.2016.10.006.
27029493Lysyl Oxidase (LOX) Transcriptionally Regulates SNAI2 Expression and TIMP4 Secretion in Human Cancers.Clin Cancer Res2016 Sep 1Boufraqech Mdoi: 10.1158/1078-0432.CCR-15-2461
27259250Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO.Oncotarget2016 Jul 5Yang Pdoi: 10.18632/oncotarget.9741.
29030587NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression.Nat Commun2017 Oct 13Ju Jdoi: 10.1038/s41467-017-00988-5.
28039463Increased risk of poor survival in ovarian cancer patients with high expression of SNAI2 and lymphovascular space invasion.Oncotarget2017 Feb 7Li Jdoi: 10.18632/oncotarget.14192.
28269747microRNA-203 suppresses invasion of gastric cancer cells by targeting ERK1/2/Slug/ E-cadherin signaling.Cancer Biomark2017Gao Pdoi: 10.3233/CBM-160167.
27036045Slug inhibits the proliferation and tumor formation of human cervical cancer cells by up-regulating the p21/p27 proteins and down-regulating the activity of the Wnt/β-catenin signaling pathway via the trans-suppression Akt1/p-Akt1 expression.Oncotarget2016 May 3Cui Ndoi: 10.18632/oncotarget.8434.
27385093TMPRSS4 induces invasion and proliferation of prostate cancer cells through induction of Slug and cyclin D1.Oncotarget2016 Aug 2Lee Ydoi: 10.18632/oncotarget.10382.
28542126Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/β-catenin/Slug pathway.Cell Death Dis2017 May 25Chen Kdoi: 10.1038/cddis.2017.138.
27174021Slug-upregulated miR-221 promotes breast cancer progression through suppressing E-cadherin expression.Sci Rep2016 May 13Pan Ydoi: 10.1038/srep25798.
30189837Decreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers.BMC Cancer2018 Sep 6Kalinkova Ldoi: 10.1186/s12885-018-4783-x.
30198421P4HA3 is Epigenetically Activated by Slug in Gastric Cancer and its Deregulation is Associated With Enhanced Metastasis and Poor Survival.Technol Cancer Res Treat2018 Jan 1Song Hdoi: 10.1177/1533033818796485.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr848920369Missense_MutationnovelG51E0.34
BLCAchr8489187363'UTRnovel0.16
BLCAchr848918965Missense_MutationnovelH217Y0.09zf-C2H2
BLCAchr8489187793'UTRnovel0.24
BLCAchr8489187793'UTRnovel0.31
BLCAchr8489212745'UTRnovel0.08
BLCAchr848919894Splice_SitenovelX209_splice0.37
BLCAchr848920193Missense_MutationnovelE110K0.34
BRCAchr8489214045'UTRnovel0.1
BRCAchr848919967Frame_Shift_DelnovelT180Cfs*200.35
BRCAchr848918905Missense_MutationnovelD237N0.05
CESCchr8489214305'UTRnovel0.22
CESCchr848918864Missense_MutationnovelF250L0.32
CESCchr848920048Missense_MutationnovelS158Y0.1
CESCchr848920148Missense_MutationnovelA125T0.24
COADchr848921206SilentnovelS20S0.25
COADchr848918831Missense_MutationNAE261D0.1
COADchr848920068SilentNAC151C0.23
COADchr8489187323'UTRnovel0.24
COADchr848920432Missense_MutationNAS30F0.27
ESCAchr848918817Missense_MutationnovelV266A0.21
ESCAchr848918874Missense_MutationnovelS247F0.29
ESCAchr848921209Nonsense_MutationnovelY19*0.49
ESCAchr848919926Missense_MutationnovelL199V0.36
ESCAchr848920067Missense_MutationnovelD152N0.16
GBMchr848918957Missense_MutationNAN219K0.16zf-C2H2
GBMchr848920120Missense_Mutationrs200799419N134S0.43
GBMchr8489213875'UTRnovel0.17
HNSCchr8489213145'UTRnovel0.39
HNSCchr848919957Missense_MutationnovelK188N0.12
HNSCchr8489213045'UTRnovel0.19
HNSCchr848920001SilentnovelL174L0.17
KIRCchr848920192Missense_MutationNAE110V0.31
KIRCchr8489213605'UTRnovel0.25
KIRPchr848918965Missense_MutationnovelH217N0.26zf-C2H2
KIRPchr848921258Missense_MutationNAR3P0.58
LIHCchr848920182SilentnovelL113L0.23
LUADchr848920424Missense_Mutationrs748128814L33V0.14
LUADchr848920039Missense_MutationnovelC161Y0.12
LUADchr848920096Missense_MutationnovelG142V0.32
LUADchr848920097Missense_MutationnovelG142W0.32
LUADchr848920068SilentNAC151C0.42
LUADchr848920318Missense_MutationnovelQ68R0.11
LUADchr8489187893'UTRnovel0.31
LUADchr848920321Missense_MutationNAA67D0.3
LUADchr848920172Missense_MutationNAL117I0.24
LUADchr848918990Splice_SitenovelX209_splice0.09
LUADchr8489213315'UTRnovel0.69
LUADchr848918915Missense_MutationnovelQ233H0.25zf-C2H2
LUADchr848920290SilentNAS77S0.08
LUADchr8489213335'UTRnovel0.1
LUADchr848920308Missense_MutationnovelN71K0.14
LUADchr848920068Missense_MutationNAC151W0.12
LUADchr848919986Missense_MutationnovelR179W0.11
LUADchr8489213095'UTRrs7561113670.38
LUADchr848920231Missense_MutationnovelK97M0.48
LUADchr848920289Nonsense_MutationnovelG78*0.53
LUSCchr848920095SilentNAG142G0.38
LUSCchr848920308SilentNAN71N0.21
LUSCchr848920166Missense_MutationnovelD119N0.26
LUSCchr848920393Missense_MutationNAP43Q0.16
LUSCchr848920229Missense_MutationNAD98Y0.29
LUSCchr848919907Missense_MutationNAR205K0.17
OVchr848920121Missense_MutationNAN134D0.14
OVchr848918987Splice_RegionNAG209G0.24
OVchr848920221Missense_MutationnovelS100R0.1
READchr848920099Missense_MutationNAS141F0.06
READchr848920284Silentrs549411169Y79Y0.22
SARCchr848919943Missense_MutationnovelA193E0.05
SKCMchr848918899Missense_MutationNAK239E0.13
SKCMchr848921209SilentNAY19Y0.07
SKCMchr848920432Missense_MutationNAS30F0.49
SKCMchr848918867SilentNAT249T0.21
SKCMchr848919930SilentnovelP197P0.19
SKCMchr848919931Missense_MutationnovelP197L0.19
SKCMchr848921254SilentNAS4S0.27
STADchr848920403Missense_MutationnovelP40S0.1
STADchr848918948Frame_Shift_DelnovelF222Lfs*70.21zf-C2H2
STADchr8489213665'UTRnovel0.61
STADchr848920289Missense_MutationNAG78R0.24
STADchr848921260SilentNAP2P0.18
STADchr848920289Missense_MutationNAG78R0.16
STADchr848918880Frame_Shift_DelnovelN245Tfs*220.17
STADchr848920005SilentNAG172G0.22
STADchr8489212975'UTRnovel0.19
STADchr848919907Missense_MutationNAR205I0.34
STADchr848920405Missense_MutationNAM39T0.05
STADchr848920023Missense_MutationnovelK166N0.06
STADchr848918813SilentnovelA267A0.15
STADchr8489213255'UTRnovel0.09
STADchr8489213095'UTRrs7561113670.23
STADchr8489213425'UTRnovel0.12
STADchr848921240Missense_MutationNAK9R0.15
STADchr8489212855'UTRrs7688514970.15
STADchr8489213025'UTRnovel0.58
STADchr848920366Missense_MutationNAA52E0.14
STADchr848920430Missense_MutationNAP31S0.12
STADchr8489212955'UTRrs7726951370.22
STADchr848918869Missense_MutationNAT249P0.19
THCAchr848920320Nonsense_MutationnovelQ68*0.02
THCAchr848920004Missense_MutationNAA173T0.41
UCECchr848918932Missense_MutationNAL228M0.33zf-C2H2
UCECchr848919951SilentnovelC190C0.46
UCECchr848920394Missense_MutationnovelP43S0.31
UCECchr848920068SilentNAC151C0.06
UCECchr8489187523'UTRnovel0.45
UCECchr848920122Nonsense_MutationnovelC133*0.33
UCECchr848920302Silentrs189890133L73L0.43
UCECchr848920403Missense_MutationnovelP40S0.36
UCECchr848918876Nonsense_MutationnovelC246*0.04
UCECchr8489187743'UTRnovel0.21
UCECchr848919981SilentNAT180T0.15
UCECchr848918864Missense_MutationnovelF250L0.43
UCECchr848920359Silentrs764570013S54S0.29
UCECchr8489187793'UTRnovel0.65
UCECchr8489187843'UTRrs2011614900.22
UCECchr8489186743'UTRnovel0.6
UCECchr8489212875'UTRnovel0.2
UCECchr8489186903'UTRnovel0.3
UCECchr8489187223'UTRnovel0.12
UCECchr848918900SilentNAV238V0.35
UCECchr848920438Missense_MutationNAI28S0.38
UCECchr848919998Missense_MutationNAK175E0.35
UCECchr8489213985'UTRNA0.39
UCECchr848918932SilentNAL228L0.36
UCECchr848920131SilentNAC130C0.31
UCECchr848918989Splice_SitenovelX209_splice0.29
UCECchr848920162Missense_MutationnovelP120L0.26
UCECchr848921232Missense_Mutationrs763952937N12D0.49
UCECchr8489186833'UTRnovel0.24
UCECchr8489187253'UTRnovel0.34

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
HNSCAMP0.51722.8683e-07
READDEL0.04850.20625
UCSAMP0.58934.2724e-06

Survival Analysis
CancerP-value Q-value
KIRC0.012

Kaplan-Meier Survival Analysis

STAD0.0035

Kaplan-Meier Survival Analysis

SARC0.033

Kaplan-Meier Survival Analysis

MESO0.00014

Kaplan-Meier Survival Analysis

ACC0.004

Kaplan-Meier Survival Analysis

HNSC0.029

Kaplan-Meier Survival Analysis

SKCM0.0046

Kaplan-Meier Survival Analysis

KIRP0.0018

Kaplan-Meier Survival Analysis

PAAD0.0047

Kaplan-Meier Survival Analysis

BLCA0.013

Kaplan-Meier Survival Analysis

LAML0.0015

Kaplan-Meier Survival Analysis

LGG0.00011

Kaplan-Meier Survival Analysis

LUAD0.005

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000019549 (Gene tree)
Gene ID
6591
Gene Symbol
SNAI2
Alias
SLUGH1|SNAIL2|SLUGH|SLUG
Full Name
snail family transcriptional repressor 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
4,137 bases
Position
chr8:48,917,604-48,921,740
Accession
11094
RBP type
canonical RBP
Summary
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000020945zf-C2H2PF00096.263.3e-2715
ENSP00000020945zf-C2H2PF00096.263.3e-2725
ENSP00000020945zf-C2H2PF00096.263.3e-2735
ENSP00000020945zf-C2H2PF00096.263.3e-2745
ENSP00000020945zf-C2H2PF00096.263.3e-2755
ENSP00000494171zf-C2H2PF00096.263.3e-2715
ENSP00000494171zf-C2H2PF00096.263.3e-2725
ENSP00000494171zf-C2H2PF00096.263.3e-2735
ENSP00000494171zf-C2H2PF00096.263.3e-2745
ENSP00000494171zf-C2H2PF00096.263.3e-2755
ENSP00000020945zf-metPF12874.76.2e-0911
ENSP00000494171zf-metPF12874.76.2e-0911

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
24164458Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells.Int J Radiat Biol2014 JanKim KSdoi: 10.3109/09553002.2014.859763.
27682981Identification of a Novel Human E-Cadherin Splice Variant and Assessment of Its Effects Upon EMT-Related Events.J Cell Physiol2017 JunMatos MLdoi: 10.1002/jcp.25622
22016846B1-SINE retrotransposons: Establishing genomic insulatory networks.Mob Genet Elements2011 MayRoman AC-
23213419sizzled function and secreted factor network dynamics.Biol Open2012 Mar 15Shi Jdoi: 10.1242/bio.2012019
27259250Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO.Oncotarget2016 Jul 5Yang Pdoi: 10.18632/oncotarget.9741.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000020945SNAI2-2012010-ENSP00000020945268 (aa)-O43623
ENST00000649776SNAI2-2042828--- (aa)--
ENST00000642303SNAI2-2032428-ENSP00000494171268 (aa)-O43623
ENST00000396822SNAI2-202626-ENSP0000038003489 (aa)-A0A1X7SC17
Gene Model
Click here to download ENSG00000019549's gene model file
Pathways
Pathway IDPathway NameSource
hsa04390Hippo signaling pathwayKEGG
hsa04520Adherens junctionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000019549Echocardiography7.18726318057076E-517903301
ENSG00000019549Autistic Disorder1.1296000E-005-
ENSG00000019549Metabolism3E-2224816252
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000019549's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000019549SNAI210098.507ENSAMEG00000009606SNAI210098.507Ailuropoda_melanoleuca
ENSG00000019549SNAI29949.329ENSANAG00000032748SNAI39946.302Aotus_nancymaae
ENSG00000019549SNAI210099.254ENSANAG00000021163SNAI210099.254Aotus_nancymaae
ENSG00000019549SNAI210093.657ENSBTAG00000013227SNAI210093.657Bos_taurus
ENSG00000019549SNAI29944.554ENSBTAG00000017528SNAI39946.575Bos_taurus
ENSG00000019549SNAI2100100.000ENSCJAG00000013499SNAI2100100.000Callithrix_jacchus
ENSG00000019549SNAI210097.761ENSCAFG00000006638SNAI210097.761Canis_familiaris
ENSG00000019549SNAI210097.761ENSCAFG00020015384SNAI210097.761Canis_lupus_dingo
ENSG00000019549SNAI210093.284ENSCHIG00000024410SNAI210093.284Capra_hircus
ENSG00000019549SNAI29946.358ENSCHIG00000018087SNAI39946.233Capra_hircus
ENSG00000019549SNAI29096.680ENSTSYG00000030892SNAI29096.680Carlito_syrichta
ENSG00000019549SNAI25372.000ENSTSYG00000025594SNAI35272.000Carlito_syrichta
ENSG00000019549SNAI28396.413ENSCAPG00000013078SNAI210096.413Cavia_aperea
ENSG00000019549SNAI2100100.000ENSCCAG00000024100SNAI2100100.000Cebus_capucinus
ENSG00000019549SNAI2100100.000ENSCATG00000028656SNAI2100100.000Cercocebus_atys
ENSG00000019549SNAI29947.231ENSCATG00000031714SNAI39946.945Cercocebus_atys
ENSG00000019549SNAI210097.015ENSCLAG00000011797SNAI210097.015Chinchilla_lanigera
ENSG00000019549SNAI2100100.000ENSCSAG00000014787SNAI2100100.000Chlorocebus_sabaeus
ENSG00000019549SNAI210093.657ENSCPBG00000020255SNAI210093.657Chrysemys_picta_bellii
ENSG00000019549SNAI29951.701ENSCPBG00000023474SNAI39951.701Chrysemys_picta_bellii
ENSG00000019549SNAI25957.962ENSCSAVG00000009819-8157.962Ciona_savignyi
ENSG00000019549SNAI2100100.000ENSCANG00000029656SNAI2100100.000Colobus_angolensis_palliatus
ENSG00000019549SNAI29947.735ENSCGRG00001011389Snai39947.038Cricetulus_griseus_chok1gshd
ENSG00000019549SNAI210096.642ENSCGRG00001013674Snai210096.642Cricetulus_griseus_chok1gshd
ENSG00000019549SNAI210096.642ENSCGRG00000012119Snai210096.642Cricetulus_griseus_crigri
ENSG00000019549SNAI29947.735ENSCGRG00000014932Snai39947.038Cricetulus_griseus_crigri
ENSG00000019549SNAI27834.234ENSDNOG00000035204-10034.821Dasypus_novemcinctus
ENSG00000019549SNAI210094.403ENSDORG00000029620Snai210094.403Dipodomys_ordii
ENSG00000019549SNAI29948.110ENSECAG00000012131SNAI39947.635Equus_caballus
ENSG00000019549SNAI210080.224ENSELUG00000021795SNAI27979.104Esox_lucius
ENSG00000019549SNAI29955.986ENSELUG00000018742-9956.597Esox_lucius
ENSG00000019549SNAI29946.237ENSFCAG00000043885SNAI39945.487Felis_catus
ENSG00000019549SNAI28963.445ENSFALG00000012974-9865.126Ficedula_albicollis
ENSG00000019549SNAI210097.761ENSFDAG00000016958SNAI210097.761Fukomys_damarensis
ENSG00000019549SNAI29951.890ENSGAGG00000023571SNAI39950.345Gopherus_agassizii
ENSG00000019549SNAI210093.657ENSGAGG00000000426SNAI210093.657Gopherus_agassizii
ENSG00000019549SNAI2100100.000ENSGGOG00000000959SNAI2100100.000Gorilla_gorilla
ENSG00000019549SNAI29949.660ENSGGOG00000012559SNAI39946.302Gorilla_gorilla
ENSG00000019549SNAI210075.093ENSHCOG00000019435SNAI210075.093Hippocampus_comes
ENSG00000019549SNAI210068.864ENSIPUG00000000131snai210069.403Ictalurus_punctatus
ENSG00000019549SNAI210097.388ENSSTOG00000028743SNAI210097.388Ictidomys_tridecemlineatus
ENSG00000019549SNAI29947.973ENSJJAG00000019934Snai39946.959Jaculus_jaculus
ENSG00000019549SNAI210086.567ENSLOCG00000005992SNAI210086.567Lepisosteus_oculatus
ENSG00000019549SNAI25286.429ENSLOCG00000004887SNAI39283.444Lepisosteus_oculatus
ENSG00000019549SNAI210096.269ENSLAFG00000009299SNAI210096.269Loxodonta_africana
ENSG00000019549SNAI29956.827ENSLAFG00000005117SNAI39956.827Loxodonta_africana
ENSG00000019549SNAI2100100.000ENSMFAG00000046061SNAI2100100.000Macaca_fascicularis
ENSG00000019549SNAI29949.320ENSMFAG00000032064SNAI39948.845Macaca_fascicularis
ENSG00000019549SNAI29949.320ENSMMUG00000008716SNAI39948.845Macaca_mulatta
ENSG00000019549SNAI2100100.000ENSMMUG00000016195SNAI2100100.000Macaca_mulatta
ENSG00000019549SNAI29949.329ENSMNEG00000045515SNAI39949.175Macaca_nemestrina
ENSG00000019549SNAI2100100.000ENSMNEG00000034216SNAI2100100.000Macaca_nemestrina
ENSG00000019549SNAI2100100.000ENSMLEG00000034407SNAI2100100.000Mandrillus_leucophaeus
ENSG00000019549SNAI29946.758ENSMAUG00000001685Snai39947.099Mesocricetus_auratus
ENSG00000019549SNAI210096.269ENSMAUG00000008119Snai210096.269Mesocricetus_auratus
ENSG00000019549SNAI29948.611ENSMOCG00000003536Snai39947.917Microtus_ochrogaster
ENSG00000019549SNAI210096.269ENSMOCG00000006622Snai210096.269Microtus_ochrogaster
ENSG00000019549SNAI210094.776ENSMODG00000010173SNAI210094.776Monodelphis_domestica
ENSG00000019549SNAI210095.911MGP_CAROLIEiJ_G0020483Snai210095.911Mus_caroli
ENSG00000019549SNAI210095.167ENSMUSG00000022676Snai210095.167Mus_musculus
ENSG00000019549SNAI210095.911MGP_PahariEiJ_G0016188Snai210095.911Mus_pahari
ENSG00000019549SNAI29947.099MGP_PahariEiJ_G0023260Snai39945.862Mus_pahari
ENSG00000019549SNAI210095.539MGP_SPRETEiJ_G0021379Snai210095.539Mus_spretus
ENSG00000019549SNAI210098.507ENSMPUG00000010793SNAI210098.507Mustela_putorius_furo
ENSG00000019549SNAI29949.474ENSMPUG00000008104SNAI39949.474Mustela_putorius_furo
ENSG00000019549SNAI210097.388ENSMLUG00000001086SNAI210097.388Myotis_lucifugus
ENSG00000019549SNAI29947.603ENSNGAG00000023039Snai39947.260Nannospalax_galili
ENSG00000019549SNAI210099.254ENSNLEG00000013421SNAI210099.254Nomascus_leucogenys
ENSG00000019549SNAI29948.993ENSNLEG00000000595SNAI39948.993Nomascus_leucogenys
ENSG00000019549SNAI29794.636ENSMEUG00000009510SNAI210094.636Notamacropus_eugenii
ENSG00000019549SNAI210094.030ENSOANG00000007267SNAI210094.030Ornithorhynchus_anatinus
ENSG00000019549SNAI29947.241ENSOGAG00000000419SNAI39948.973Otolemur_garnettii
ENSG00000019549SNAI210093.284ENSOARG00000013030SNAI210093.284Ovis_aries
ENSG00000019549SNAI2100100.000ENSPPAG00000015662SNAI2100100.000Pan_paniscus
ENSG00000019549SNAI29949.320ENSPPAG00000043301SNAI39945.981Pan_paniscus
ENSG00000019549SNAI29946.520ENSPPRG00000008511SNAI39946.931Panthera_pardus
ENSG00000019549SNAI210097.761ENSPPRG00000012562-10097.761Panthera_pardus
ENSG00000019549SNAI29097.521ENSPTIG00000007593SNAI27797.521Panthera_tigris_altaica
ENSG00000019549SNAI2100100.000ENSPTRG00000020235SNAI2100100.000Pan_troglodytes
ENSG00000019549SNAI29950.000ENSPTRG00000008460SNAI39946.302Pan_troglodytes
ENSG00000019549SNAI2100100.000ENSPANG00000017540SNAI2100100.000Papio_anubis
ENSG00000019549SNAI29947.557ENSPANG00000000509SNAI39947.267Papio_anubis
ENSG00000019549SNAI29955.290ENSPKIG00000007872SNAI39954.237Paramormyrops_kingsleyae
ENSG00000019549SNAI210084.328ENSPKIG00000002254SNAI210084.328Paramormyrops_kingsleyae
ENSG00000019549SNAI210093.284ENSPSIG00000016395SNAI210093.284Pelodiscus_sinensis
ENSG00000019549SNAI27362.626ENSPSIG00000004262SNAI35680.986Pelodiscus_sinensis
ENSG00000019549SNAI210077.985ENSPMGG00000013179SNAI210076.493Periophthalmus_magnuspinnatus
ENSG00000019549SNAI210096.269ENSPEMG00000011739Snai210096.269Peromyscus_maniculatus_bairdii
ENSG00000019549SNAI210095.149ENSPCIG00000025156SNAI210095.149Phascolarctos_cinereus
ENSG00000019549SNAI29078.926ENSPREG00000008528SNAI28677.273Poecilia_reticulata
ENSG00000019549SNAI29947.697ENSPPYG00000007643SNAI39946.624Pongo_abelii
ENSG00000019549SNAI2100100.000ENSPPYG00000018578SNAI2100100.000Pongo_abelii
ENSG00000019549SNAI210097.761ENSPCOG00000015656SNAI210097.761Propithecus_coquereli
ENSG00000019549SNAI210097.388ENSPVAG00000009457SNAI210097.388Pteropus_vampyrus
ENSG00000019549SNAI29946.416ENSRNOG00000013586Snai39946.367Rattus_norvegicus
ENSG00000019549SNAI29949.329ENSRBIG00000025770SNAI39949.175Rhinopithecus_bieti
ENSG00000019549SNAI2100100.000ENSRBIG00000041133SNAI2100100.000Rhinopithecus_bieti
ENSG00000019549SNAI2100100.000ENSRROG00000032273SNAI2100100.000Rhinopithecus_roxellana
ENSG00000019549SNAI29948.993ENSRROG00000032757SNAI39948.845Rhinopithecus_roxellana
ENSG00000019549SNAI2100100.000ENSSBOG00000035774SNAI2100100.000Saimiri_boliviensis_boliviensis
ENSG00000019549SNAI210095.149ENSSHAG00000004205SNAI210095.149Sarcophilus_harrisii
ENSG00000019549SNAI210084.074ENSSFOG00015018025SNAI210084.074Scleropages_formosus
ENSG00000019549SNAI29950.327ENSSFOG00015016115snai39350.325Scleropages_formosus
ENSG00000019549SNAI210092.910ENSSPUG00000005427-10092.910Sphenodon_punctatus
ENSG00000019549SNAI210095.149ENSSSCG00000039568SNAI210095.149Sus_scrofa
ENSG00000019549SNAI29944.898ENSTTRG00000006262SNAI39945.804Tursiops_truncatus
ENSG00000019549SNAI29949.827ENSUAMG00000020030SNAI39948.013Ursus_americanus
ENSG00000019549SNAI28698.696ENSUAMG00000014942SNAI210098.696Ursus_americanus
ENSG00000019549SNAI29898.099ENSUMAG00000006525SNAI210098.099Ursus_maritimus
ENSG00000019549SNAI210098.134ENSVVUG00000017625SNAI210098.134Vulpes_vulpes
ENSG00000019549SNAI29947.635ENSVVUG00000003233SNAI39945.161Vulpes_vulpes
ENSG00000019549SNAI210088.806ENSXETG00000024006snai210088.806Xenopus_tropicalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II10866665.11912130.IDAProcess
GO:0000122negative regulation of transcription by RNA polymerase II18663143.IMPProcess
GO:0000790nuclear chromatin19756381.IDAComponent
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding11912130.IDAFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific-ISAFunction
GO:0000981DNA-binding transcription factor activity, RNA polymerase II-specific19274049.NASFunction
GO:0001227DNA-binding transcription repressor activity, RNA polymerase II-specific10866665.11912130.16707493.18663143.IDAFunction
GO:0001649osteoblast differentiation20128911.IEPProcess
GO:0001837epithelial to mesenchymal transition9182671.17984306.IMPProcess
GO:0003180aortic valve morphogenesis20951801.TASProcess
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation-ISSProcess
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation20951801.TASProcess
GO:0003273cell migration involved in endocardial cushion formation-ISSProcess
GO:0003677DNA binding21873635.IBAFunction
GO:0003682chromatin binding-IEAFunction
GO:0003700DNA-binding transcription factor activity21873635.IBAFunction
GO:0005515protein binding25416956.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus10866665.25893292.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm-IEAComponent
GO:0006355regulation of transcription, DNA-templated21873635.IBAProcess
GO:0006933negative regulation of cell adhesion involved in substrate-bound cell migration-IEAProcess
GO:0007219Notch signaling pathway18663143.IMPProcess
GO:0007605sensory perception of sound12444107.IMPProcess
GO:0010839negative regulation of keratinocyte proliferation16707493.IDAProcess
GO:0010957negative regulation of vitamin D biosynthetic process18485278.19502595.IDAProcess
GO:0014032neural crest cell development12444107.IMPProcess
GO:0030335positive regulation of cell migration15314165.IMPProcess
GO:0032331negative regulation of chondrocyte differentiation19756381.IMPProcess
GO:0032642regulation of chemokine production21182836.IMPProcess
GO:0033629negative regulation of cell adhesion mediated by integrin16707493.ICProcess
GO:0035066positive regulation of histone acetylation-IEAProcess
GO:0035921desmosome disassembly9182671.IMPProcess
GO:0043473pigmentation12444107.IMPProcess
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator15314165.IMPProcess
GO:0043565sequence-specific DNA binding10518215.10866665.IDAFunction
GO:0045600positive regulation of fat cell differentiation-IEAProcess
GO:0045667regulation of osteoblast differentiation19756381.21182836.IMPProcess
GO:0046872metal ion binding-IEAFunction
GO:0050872white fat cell differentiation-IEAProcess
GO:0060021roof of mouth development-IEAProcess
GO:0060429epithelium development18716062.ISSProcess
GO:0060536cartilage morphogenesis-IEAProcess
GO:0060693regulation of branching involved in salivary gland morphogenesis-IEAProcess
GO:0061314Notch signaling involved in heart development20951801.TASProcess
GO:0070563negative regulation of vitamin D receptor signaling pathway19502595.IDAProcess
GO:0070888E-box binding11912130.IDAFunction
GO:0071364cellular response to epidermal growth factor stimulus18716062.IDAProcess
GO:0071479cellular response to ionizing radiation-IEAProcess
GO:0090090negative regulation of canonical Wnt signaling pathway19502595.IDAProcess
GO:0090090negative regulation of canonical Wnt signaling pathway19756381.IMPProcess
GO:1900387negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter15737616.16707493.17984306.IMPProcess
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage15314165.IMPProcess
GO:2000647negative regulation of stem cell proliferation-IEAProcess
GO:2000810regulation of bicellular tight junction assembly15314165.IMPProcess
GO:2000811negative regulation of anoikis17984306.IMPProcess
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand10518215.ISSProcess
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