EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28538732	CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.	Nature	2017 Jun 1	Kim J	doi: 10.1038/nature22359

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	210591858	Silent	novel	I325I	0.38
ACC	chr2	210592935	Silent	novel	T381T	0.43
ACC	chr2	210647943	Missense_Mutation	novel	K1074N	0.32
ACC	chr2	210663122	Splice_Site	novel	X1310_splice	0.29
BLCA	chr2	210599448	Missense_Mutation	rs187860166	A479V	0.44
BLCA	chr2	210660571	Silent	NA	K1281K	0.29
BLCA	chr2	210648538	Splice_Region	NA	L1134L	0.09
BLCA	chr2	210590105	Splice_Site	novel	X238_splice	0.12
BLCA	chr2	210556769	Missense_Mutation	novel	R12S	0.13
BLCA	chr2	210658638	Missense_Mutation	rs767193495	I1236V	0.11
BLCA	chr2	210556677	5'UTR	novel		0.42
BLCA	chr2	210590119	Missense_Mutation	NA	V242A	0.49
BLCA	chr2	210600693	Missense_Mutation	novel	P563L	0.27
BLCA	chr2	210612181	Missense_Mutation	NA	S819C	0.24
BLCA	chr2	210648520	Missense_Mutation	NA	L1128F	0.2
BLCA	chr2	210599562	Splice_Site	novel	X517_splice	0.23
BLCA	chr2	210608421	Missense_Mutation	NA	K751N	0.42
BLCA	chr2	210675786	Missense_Mutation	NA	P1407L	0.51
BLCA	chr2	210660594	Missense_Mutation	novel	D1289G	0.82
BRCA	chr2	210612272	Silent	rs371426184	T849T	0.24
BRCA	chr2	210591953	Missense_Mutation	rs761817028	N357S	0.28
BRCA	chr2	210647954	Missense_Mutation	NA	T1078R	0.25
BRCA	chr2	210582657	Missense_Mutation	novel	V190A	0.09
BRCA	chr2	210600657	Missense_Mutation	NA	S551L	0.36
BRCA	chr2	210605126	Silent	NA	L621L	0.17
BRCA	chr2	210606887	Missense_Mutation	NA	I713S	0.22
BRCA	chr2	210675763	Silent	rs548201746	N1399N	0.4
BRCA	chr2	210590858	Missense_Mutation	NA	T300I	0.32
BRCA	chr2	210678077	3'UTR	novel		0.31
BRCA	chr2	210639184	Missense_Mutation	NA	T955K	0.36
BRCA	chr2	210602236	Missense_Mutation	novel	G581D	0.05
BRCA	chr2	210594602	Missense_Mutation	novel	V420A	0.04
BRCA	chr2	210616534	Missense_Mutation	NA	L894V	0.17
BRCA	chr2	210654073	Missense_Mutation	novel	E1177Q	0.11
BRCA	chr2	210656603	Missense_Mutation	rs774692248	Q1213K	0.27
BRCA	chr2	210588057	Splice_Site	NA	X208_splice	0.22
BRCA	chr2	210647869	Missense_Mutation	NA	G1050S	0.19
BRCA	chr2	210594537	Missense_Mutation	NA	I398M	0.23
BRCA	chr2	210654074	Missense_Mutation	novel	E1177G	0.12
BRCA	chr2	210606932	Nonsense_Mutation	novel	K728delinsNYFSSSFH	0.45
BRCA	chr2	210660640	Frame_Shift_Ins	novel	*Y1305Rfs9**	0.09
BRCA	chr2	210660553	Missense_Mutation	NA	F1275L	0.21
BRCA	chr2	210647885	Missense_Mutation	novel	S1055L	0.28
BRCA	chr2	210606770	Missense_Mutation	NA	N674I	0.14
BRCA	chr2	210582651	Missense_Mutation	rs376091629	Q188R	0.14
CESC	chr2	210602321	Silent	NA	L609L	0.43
CESC	chr2	210582682	Silent	rs150369462	Q198Q	0.33
CESC	chr2	210556757	Silent	novel	F8F	0.36
CESC	chr2	210650393	Frame_Shift_Ins	novel	*D1146Mfs4**	0.15
CESC	chr2	210576441	Missense_Mutation	novel	A111V	0.35
CESC	chr2	210590177	Silent	rs142468138	I261I	0.37
CESC	chr2	210602316	Missense_Mutation	novel	D608N	0.4
CESC	chr2	210668199	Missense_Mutation	novel	G1339D	0.43
CESC	chr2	210556824	Missense_Mutation	NA	F31I	0.33
CESC	chr2	210678024	3'UTR	novel		0.09
CESC	chr2	210663193	Missense_Mutation	novel	G1333A	0.48
COAD	chr2	210576468	Missense_Mutation	NA	Y120C	0.52
COAD	chr2	210590899	Missense_Mutation	NA	A314T	0.23
COAD	chr2	210595541	Nonsense_Mutation	NA	E440*	0.29
COAD	chr2	210642563	Silent	novel	V1013V	0.25
COAD	chr2	210616521	Missense_Mutation	novel	K889N	0.4
COAD	chr2	210677024	Missense_Mutation	rs754446815	S1431N	0.36
COAD	chr2	210650420	Missense_Mutation	NA	E1154D	0.39
COAD	chr2	210660643	Silent	novel	Y1305Y	0.38
COAD	chr2	210590167	Missense_Mutation	NA	G258E	0.41
COAD	chr2	210658630	Missense_Mutation	NA	A1233D	0.37
COAD	chr2	210602324	Missense_Mutation	novel	S610R	0.17
COAD	chr2	210612201	Missense_Mutation	rs757451824	R826C	0.65
COAD	chr2	210677090	Missense_Mutation	NA	R1453Q	0.21
COAD	chr2	210606769	Missense_Mutation	novel	N674D	0.14
COAD	chr2	210599512	Silent	novel	Q500Q	0.38
COAD	chr2	210594576	Silent	rs779447126	P411P	0.18
COAD	chr2	210606911	Missense_Mutation	rs752339705	R721Q	0.38
COAD	chr2	210639192	Missense_Mutation	novel	L958I	0.07
COAD	chr2	210477760	5'UTR	novel		0.12
COAD	chr2	210594522	Silent	novel	S393S	0.26
COAD	chr2	210608528	Missense_Mutation	rs571936934	R787Q	0.37
COAD	chr2	210639186	Missense_Mutation	NA	N956H	0.28
COAD	chr2	210576399	Missense_Mutation	novel	A97D	0.34
COAD	chr2	210648043	Missense_Mutation	NA	A1108S	0.22
COAD	chr2	210590816	Missense_Mutation	rs148654695	R286H	0.2
COAD	chr2	210654047	Missense_Mutation	novel	K1168T	0.07
COAD	chr2	210595550	Missense_Mutation	NA	Y443H	0.13
COAD	chr2	210677942	Nonsense_Mutation	novel	*S1487Rfs2**	0.06
COAD	chr2	210677944	Missense_Mutation	novel	L1488F	0.01
COAD	chr2	210678024	3'UTR	novel		0.07
COAD	chr2	210647879	Missense_Mutation	novel	I1053N	0.28
COAD	chr2	210612165	Missense_Mutation	rs772782772	R814W	0.41
COAD	chr2	210642526	Missense_Mutation	rs545355868	R1001H	0.24
COAD	chr2	210608476	Missense_Mutation	novel	V770I	0.13
DLBC	chr2	210556651	5'UTR	novel		0.24
DLBC	chr2	210616424	Missense_Mutation	novel	A857D	0.37
DLBC	chr2	210599551	Silent	novel	A513A	0.21
ESCA	chr2	210677123	Missense_Mutation	novel	L1464P	0.14
ESCA	chr2	210606911	Missense_Mutation	rs752339705	R721Q	0.38
ESCA	chr2	210582650	Missense_Mutation	NA	Q188K	0.07
ESCA	chr2	210650439	Splice_Site	novel	X1160_splice	0.23
ESCA	chr2	210647906	Missense_Mutation	novel	N1062T	0.16
ESCA	chr2	210677897	Missense_Mutation	NA	L1472R	0.39
ESCA	chr2	210660500	Missense_Mutation	novel	L1258M	0.29
ESCA	chr2	210556741	Missense_Mutation	novel	R3K	0.29
GBM	chr2	210677072	Missense_Mutation	novel	H1447P	0.14
GBM	chr2	210677979	Silent	novel	A1499A	0.05
GBM	chr2	210612171	Missense_Mutation	NA	C816R	0.03
GBM	chr2	210678018	3'UTR	novel		0.09
GBM	chr2	210640045	Missense_Mutation	rs121912595	G982D	0.83
GBM	chr2	210642525	Missense_Mutation	novel	R1001S	0.2
GBM	chr2	210675752	Missense_Mutation	novel	D1396N	0.34
GBM	chr2	210642647	Silent	novel	L1041L	0.08
GBM	chr2	210556798	Missense_Mutation	novel	N22S	0.04
GBM	chr2	210637703	Nonsense_Mutation	novel	E897*	0.07
GBM	chr2	210678091	3'UTR	novel		0.13
GBM	chr2	210616498	Missense_Mutation	rs148519116	R882C	0.46
GBM	chr2	210677082	Nonsense_Mutation	novel	Y1450*	0.04
GBM	chr2	210654082	Missense_Mutation	rs776047286	A1180T	0.25
GBM	chr2	210576395	Missense_Mutation	NA	M96V	0.31
GBM	chr2	210605156	Missense_Mutation	NA	E631Q	0.27
GBM	chr2	210608466	Silent	novel	L766L	0.04
GBM	chr2	210650422	Missense_Mutation	rs766125631	A1155V	0.32
HNSC	chr2	210556775	Silent	novel	L14L	0.06
HNSC	chr2	210599552	Silent	novel	L514L	0.23
HNSC	chr2	210608434	Missense_Mutation	rs773998721	G756R	0.47
HNSC	chr2	210594575	Missense_Mutation	rs769284353	P411L	0.22
HNSC	chr2	210608432	Missense_Mutation	NA	S755F	0.37
HNSC	chr2	210606936	Silent	novel	A729A	0.1
HNSC	chr2	210606773	Missense_Mutation	NA	A675V	0.5
HNSC	chr2	210637724	Missense_Mutation	novel	L904V	0.15
HNSC	chr2	210674932	Missense_Mutation	novel	A1378S	0.26
HNSC	chr2	210606814	Missense_Mutation	rs147443001	R689C	0.16
HNSC	chr2	210608512	Missense_Mutation	novel	H782Y	0.18
HNSC	chr2	210599524	Missense_Mutation	novel	L504F	0.27
HNSC	chr2	210654055	Missense_Mutation	novel	E1171Q	0.16
HNSC	chr2	210656569	Silent	novel	V1201V	0.62
HNSC	chr2	210674937	Silent	novel	E1379E	0.24
HNSC	chr2	210639192	Missense_Mutation	NA	L958V	0.08
KIRC	chr2	210608488	Missense_Mutation	NA	P774T	0.13
KIRC	chr2	210612237	Missense_Mutation	rs746628905	D838N	0.28
KIRC	chr2	210556684	5'UTR	novel		0.29
KIRC	chr2	210656608	Silent	NA	T1214T	0.46
KIRC	chr2	210576363	Missense_Mutation	NA	T85S	0.22
KIRP	chr2	210658688	Missense_Mutation	novel	L1252F	0.24
KIRP	chr2	210678084	3'UTR	novel		0.35
KIRP	chr2	210579763	Missense_Mutation	NA	R174Q	0.15
KIRP	chr2	210606881	Missense_Mutation	NA	C711F	0.18
LAML	chr2	210647892	Silent	novel	G1057G	0.07
LAML	chr2	210573353	Missense_Mutation	novel	F61Y	0.03
LGG	chr2	210606825	Silent	NA	G692G	0.53
LGG	chr2	210660657	Splice_Site	NA	X1309_splice	0.39
LGG	chr2	210605246	Missense_Mutation	novel	G661C	0.07
LGG	chr2	210650370	Missense_Mutation	novel	A1138T	0.11
LIHC	chr2	210556647	5'UTR	novel		0.53
LIHC	chr2	210577467	Nonsense_Mutation	novel	W143*	0.09
LIHC	chr2	210663144	Missense_Mutation	NA	R1317W	0.17
LIHC	chr2	210660510	Missense_Mutation	novel	S1261F	0.22
LIHC	chr2	210556607	5'UTR	novel		0.26
LIHC	chr2	210594539	Missense_Mutation	novel	K399R	0.25
LIHC	chr2	210647950	Missense_Mutation	NA	G1077R	0.26
LIHC	chr2	210606911	Missense_Mutation	NA	R721L	0.41
LIHC	chr2	210590816	Missense_Mutation	rs148654695	R286H	0.42
LIHC	chr2	210608462	Missense_Mutation	novel	S765N	0.25
LIHC	chr2	210600634	Silent	novel	A543A	0.51
LIHC	chr2	210591864	Frame_Shift_Ins	novel	*Q329Tfs34**	0.2
LUAD	chr2	210616444	Missense_Mutation	NA	L864I	0.29
LUAD	chr2	210599536	Missense_Mutation	NA	M508I	0.31
LUAD	chr2	210616455	Missense_Mutation	novel	I867M	0.13
LUAD	chr2	210556803	Missense_Mutation	rs752849933	T24A	0.09
LUAD	chr2	210595551	Missense_Mutation	novel	Y443F	0.16
LUAD	chr2	210605148	Missense_Mutation	novel	G628V	0.39
LUAD	chr2	210612288	Missense_Mutation	novel	A855S	0.25
LUAD	chr2	210654028	Missense_Mutation	NA	H1162Y	0.29
LUAD	chr2	210637816	Missense_Mutation	novel	K934N	0.11
LUAD	chr2	210595557	Missense_Mutation	novel	G445V	0.11
LUAD	chr2	210640044	Missense_Mutation	novel	G982C	0.11
LUAD	chr2	210599516	Missense_Mutation	novel	D502H	0.04
LUAD	chr2	210582688	Missense_Mutation	novel	L200F	0.31
LUAD	chr2	210677984	Nonstop_Mutation	NA	1501Wext13	0.27
LUAD	chr2	210600684	Missense_Mutation	NA	K560T	0.49
LUAD	chr2	210678037	3'UTR	novel		0.14
LUAD	chr2	210648005	Missense_Mutation	novel	V1095A	0.1
LUAD	chr2	210591884	Missense_Mutation	NA	A334D	0.09
LUAD	chr2	210599528	Missense_Mutation	novel	L506M	0.19
LUAD	chr2	210595492	Silent	novel	S423S	0.32
LUAD	chr2	210600629	Missense_Mutation	NA	M542L	0.24
LUAD	chr2	210647970	Silent	NA	I1083I	0.38
LUAD	chr2	210677956	Missense_Mutation	NA	R1492G	0.1
LUAD	chr2	210600560	Missense_Mutation	novel	E519Q	0.11
LUAD	chr2	210612206	Silent	NA	L827L	0.26
LUAD	chr2	210637730	Missense_Mutation	novel	R906W	0.35
LUAD	chr2	210637731	Missense_Mutation	rs749952015	R906M	0.37
LUAD	chr2	210556802	Silent	NA	V23V	0.19
LUAD	chr2	210640028	Missense_Mutation	NA	M976I	0.12
LUAD	chr2	210606871	Missense_Mutation	novel	M708L	0.11
LUAD	chr2	210612261	Missense_Mutation	rs200069420	P846S	0.25
LUAD	chr2	210660502	Missense_Mutation	NA	L1258F	0.19
LUAD	chr2	210576393	Missense_Mutation	NA	T95K	0.39
LUAD	chr2	210677896	Frame_Shift_Del	rs755682125	*L1472Ffs48**	0.26
LUAD	chr2	210654088	Missense_Mutation	novel	G1182C	0.26
LUAD	chr2	210582667	Silent	novel	V193V	0.14
LUAD	chr2	210608367	Silent	rs780079490	P733P	0.6
LUAD	chr2	210663156	Missense_Mutation	NA	A1321S	0.11
LUAD	chr2	210677071	Missense_Mutation	NA	H1447D	0.21
LUAD	chr2	210642498	Missense_Mutation	novel	F992L	0.25
LUAD	chr2	210599510	Missense_Mutation	novel	Q500K	0.21
LUAD	chr2	210677091	Silent	novel	R1453R	0.22
LUAD	chr2	210600585	Missense_Mutation	novel	K527T	0.07
LUAD	chr2	210663158	Silent	novel	A1321A	0.08
LUAD	chr2	210648492	Missense_Mutation	NA	A1119V	0.16
LUAD	chr2	210592887	Frame_Shift_Del	novel	*M365Ifs21**	0.18
LUAD	chr2	210660645	Missense_Mutation	NA	V1306A	0.24
LUAD	chr2	210591966	Silent	novel	N361N	0.19
LUAD	chr2	210592888	Missense_Mutation	novel	H366Y	0.15
LUAD	chr2	210606822	Missense_Mutation	novel	L691F	0.28
LUAD	chr2	210650384	Silent	NA	V1142V	0.11
LUAD	chr2	210602240	Frame_Shift_Del	novel	*P583Qfs2**	0.11
LUAD	chr2	210590174	Missense_Mutation	NA	L260F	0.22
LUAD	chr2	210582707	Missense_Mutation	NA	K207E	0.17
LUAD	chr2	210668272	Silent	novel	L1363L	0.06
LUAD	chr2	210668183	Splice_Region	rs779886770		0.48
LUAD	chr2	210591958	Missense_Mutation	novel	Q359K	0.27
LUAD	chr2	210590132	Silent	NA	P246P	0.2
LUAD	chr2	210640040	Silent	NA	G980G	0.31
LUAD	chr2	210590188	Missense_Mutation	NA	P265Q	0.31
LUAD	chr2	210590148	Missense_Mutation	novel	T252S	0.28
LUAD	chr2	210612132	Missense_Mutation	NA	R803S	0.13
LUAD	chr2	210639999	Missense_Mutation	NA	H967N	0.17
LUAD	chr2	210663123	Missense_Mutation	NA	A1310S	0.18
LUAD	chr2	210588097	Missense_Mutation	NA	V221L	0.12
LUAD	chr2	210590851	Silent	NA	L298L	0.08
LUAD	chr2	210590202	Missense_Mutation	novel	L270F	0.12
LUAD	chr2	210590866	Missense_Mutation	NA	A303S	0.29
LUAD	chr2	210591904	Missense_Mutation	novel	L341M	0.2
LUAD	chr2	210663151	Missense_Mutation	novel	R1319M	0.31
LUAD	chr2	210579739	Missense_Mutation	NA	T166I	0.07
LUAD	chr2	210599403	Missense_Mutation	novel	P464Q	0.23
LUAD	chr2	210594574	Missense_Mutation	NA	P411S	0.2
LUAD	chr2	210599403	Missense_Mutation	NA	P464R	0.2
LUAD	chr2	210648483	Missense_Mutation	NA	L1116P	0.14
LUAD	chr2	210668184	Splice_Site	NA	X1335_splice	0.16
LUAD	chr2	210660482	Splice_Region	novel		0.12
LUAD	chr2	210663128	Silent	novel	P1311P	0.1
LUAD	chr2	210663144	Silent	NA	R1317R	0.1
LUAD	chr2	210677925	Frame_Shift_Ins	novel	*V1483Gfs29**	0.18
LUAD	chr2	210576351	Missense_Mutation	novel	P81Q	0.2
LUAD	chr2	210577471	Silent	novel	L144L	0.08
LUAD	chr2	210602284	Nonsense_Mutation	novel	S597*	0.04
LUAD	chr2	210573300	Splice_Region	NA	A43A	0.08
LUAD	chr2	210591955	Missense_Mutation	rs149930500	D358N	0.42
LUAD	chr2	210677957	Missense_Mutation	novel	R1492M	0.25
LUAD	chr2	210599417	Missense_Mutation	NA	V469F	0.19
LUAD	chr2	210650423	Silent	NA	A1155A	0.42
LUSC	chr2	210577489	Silent	rs771266355	G150G	0.13
LUSC	chr2	210588063	Silent	NA	V209V	0.24
LUSC	chr2	210608559	Missense_Mutation	novel	E797D	0.28
LUSC	chr2	210660513	Missense_Mutation	rs750670270	R1262Q	0.17
LUSC	chr2	210612167	Silent	novel	R814R	0.34
LUSC	chr2	210640019	Silent	novel	D973D	0.1
LUSC	chr2	210668255	Missense_Mutation	novel	P1358S	0.26
LUSC	chr2	210654085	Missense_Mutation	rs759207426	V1181I	0.29
LUSC	chr2	210595529	Missense_Mutation	novel	G436R	0.11
LUSC	chr2	210647926	Missense_Mutation	rs768796044	Y1069H	0.27
LUSC	chr2	210599475	Missense_Mutation	novel	T488N	0.19
LUSC	chr2	210599478	Missense_Mutation	novel	P489H	0.24
LUSC	chr2	210582650	Missense_Mutation	NA	Q188K	0.56
LUSC	chr2	210637806	Missense_Mutation	NA	L931R	0.48
LUSC	chr2	210637733	Missense_Mutation	novel	A907S	0.14
LUSC	chr2	210616443	Silent	NA	S863S	0.35
LUSC	chr2	210616444	Missense_Mutation	NA	L864I	0.35
LUSC	chr2	210650411	Missense_Mutation	novel	F1151L	0.23
LUSC	chr2	210639213	Missense_Mutation	novel	Q965K	0.68
LUSC	chr2	210637821	Missense_Mutation	novel	N936I	0.25
LUSC	chr2	210612271	Missense_Mutation	NA	T849K	0.12
LUSC	chr2	210590869	Missense_Mutation	rs750254669	A304T	0.09
LUSC	chr2	210675772	Missense_Mutation	novel	N1402K	0.24
LUSC	chr2	210640045	Missense_Mutation	rs121912595	G982V	0.43
LUSC	chr2	210592945	Missense_Mutation	rs764905536	I385V	0.04
LUSC	chr2	210599453	Missense_Mutation	novel	T481S	0.46
LUSC	chr2	210660561	Missense_Mutation	novel	V1278E	0.26
LUSC	chr2	210642553	Missense_Mutation	novel	T1010K	0.57
LUSC	chr2	210677964	Silent	rs769692031	Y1494Y	0.42
LUSC	chr2	210606824	Missense_Mutation	NA	G692D	0.61
LUSC	chr2	210612132	Missense_Mutation	NA	R803S	0.43
LUSC	chr2	210591834	Silent	novel	G317G	0.29
LUSC	chr2	210674929	Missense_Mutation	novel	V1377M	0.26
LUSC	chr2	210605232	Missense_Mutation	NA	M656K	0.26
LUSC	chr2	210605233	Missense_Mutation	NA	M656I	0.27
LUSC	chr2	210605202	Missense_Mutation	NA	T646I	0.1
LUSC	chr2	210608366	Missense_Mutation	NA	P733L	0.1
LUSC	chr2	210573360	Missense_Mutation	NA	H63Q	0.12
LUSC	chr2	210595534	Missense_Mutation	NA	Q437H	0.19
LUSC	chr2	210556724	5'UTR	novel		0.3
LUSC	chr2	210605129	Missense_Mutation	novel	V622L	0.21
LUSC	chr2	210582647	Missense_Mutation	NA	G187C	0.28
LUSC	chr2	210579722	Silent	novel	A160A	0.32
LUSC	chr2	210648472	Splice_Site	novel	X1113_splice	0.08
LUSC	chr2	210648503	Missense_Mutation	NA	D1123N	0.33
LUSC	chr2	210600581	Missense_Mutation	rs775632596	L526F	0.39
LUSC	chr2	210677059	Missense_Mutation	NA	T1443A	0.21
LUSC	chr2	210588072	Nonsense_Mutation	novel	Y212*	0.12
LUSC	chr2	210477767	Splice_Site	NA	X1_splice	0.19
LUSC	chr2	210637701	Splice_Site	NA	X896_splice	0.16
LUSC	chr2	210608371	Missense_Mutation	novel	A735S	0.16
LUSC	chr2	210637738	Missense_Mutation	NA	K908N	0.17
LUSC	chr2	210648004	Missense_Mutation	NA	V1095I	0.29
LUSC	chr2	210606736	Missense_Mutation	novel	S663A	0.23
LUSC	chr2	210582690	Missense_Mutation	NA	I201N	0.07
LUSC	chr2	210656586	Missense_Mutation	NA	T1207N	0.29
LUSC	chr2	210606802	Missense_Mutation	novel	I685F	0.23
LUSC	chr2	210639192	Missense_Mutation	novel	L958I	0.59
LUSC	chr2	210605129	Missense_Mutation	NA	V622L	0.1
LUSC	chr2	210599458	Silent	NA	V482V	0.24
LUSC	chr2	210677931	Silent	novel	V1483V	0.28
LUSC	chr2	210582655	Silent	novel	P189P	0.63
LUSC	chr2	210660616	Missense_Mutation	NA	L1296F	0.19
LUSC	chr2	210677015	Missense_Mutation	novel	R1428T	0.15
LUSC	chr2	210608474	Missense_Mutation	novel	M769T	0.26
LUSC	chr2	210640053	Missense_Mutation	novel	H985D	0.14
LUSC	chr2	210602280	Missense_Mutation	novel	G596C	0.17
LUSC	chr2	210656613	Missense_Mutation	novel	S1216I	0.16
LUSC	chr2	210606774	Silent	rs143913650	A675A	0.13
LUSC	chr2	210606940	Missense_Mutation	NA	G731C	0.38
LUSC	chr2	210647966	Missense_Mutation	NA	Q1082P	0.31
LUSC	chr2	210637707	Missense_Mutation	NA	S898C	0.18
LUSC	chr2	210677040	Silent	novel	I1436I	0.2
LUSC	chr2	210677965	Missense_Mutation	novel	S1495C	0.21
LUSC	chr2	210650421	Missense_Mutation	NA	A1155S	0.07
LUSC	chr2	210595491	Missense_Mutation	NA	S423F	0.17
LUSC	chr2	210556769	Missense_Mutation	novel	R12S	0.12
LUSC	chr2	210647927	Missense_Mutation	novel	Y1069F	0.07
OV	chr2	210612265	Missense_Mutation	NA	S847T	0.57
OV	chr2	210612260	Missense_Mutation	novel	E845D	0.03
OV	chr2	210599514	Missense_Mutation	NA	P501L	0.54
OV	chr2	210668230	Silent	novel	A1349A	0.31
OV	chr2	210677978	Nonsense_Mutation	novel	*A1500Ffs6**	0.14
OV	chr2	210602211	Missense_Mutation	NA	A573S	0.3
OV	chr2	210608477	Missense_Mutation	novel	V770A	0.06
OV	chr2	210599442	Missense_Mutation	novel	K477M	0.04
OV	chr2	210556720	5'UTR	novel		0.45
OV	chr2	210576491	Splice_Site	NA	X127_splice	0.37
OV	chr2	210556836	Missense_Mutation	NA	G35S	0.31
OV	chr2	210591938	Frame_Shift_Del	NA	*F353Lfs2**	0.61
OV	chr2	210576391	Silent	NA	L94L	0.43
OV	chr2	210577425	Nonsense_Mutation	novel	S129*	0.04
OV	chr2	210591862	Missense_Mutation	novel	N327H	0.09
OV	chr2	210678033	3'UTR	novel		0.13
OV	chr2	210595520	Silent	NA	L433L	0.43
PAAD	chr2	210590157	Missense_Mutation	rs756021170	E255K	0.22
PAAD	chr2	210616427	Missense_Mutation	novel	I858N	0.16
PAAD	chr2	210637767	Nonsense_Mutation	novel	S918*	0.19
PAAD	chr2	210668284	Splice_Region	novel	Q1367Q	0.27
PRAD	chr2	210590180	Silent	rs761172541	A262A	0.04
PRAD	chr2	210640019	Missense_Mutation	novel	D973E	0.38
PRAD	chr2	210612165	Missense_Mutation	rs772782772	R814W	0.09
PRAD	chr2	210654034	Missense_Mutation	novel	V1164M	0.17
PRAD	chr2	210677070	Silent	NA	V1446V	0.35
PRAD	chr2	210573330	Silent	NA	G53G	0.35
PRAD	chr2	210556832	Silent	NA	R33R	0.06
READ	chr2	210637815	Missense_Mutation	NA	K934T	0.25
READ	chr2	210602244	Missense_Mutation	novel	V584M	0.3
READ	chr2	210605162	Nonsense_Mutation	NA	E633*	0.17
READ	chr2	210556748	Missense_Mutation	novel	L5F	0.33
READ	chr2	210602306	Missense_Mutation	novel	E604D	0.4
READ	chr2	210608528	Missense_Mutation	rs571936934	R787Q	0.42
READ	chr2	210612167	Silent	novel	R814R	0.08
READ	chr2	210648472	Splice_Site	novel	X1113_splice	0.42
READ	chr2	210654067	Nonsense_Mutation	novel	E1175*	0.4
READ	chr2	210660557	Missense_Mutation	novel	D1277Y	0.4
READ	chr2	210658615	Missense_Mutation	rs778117194	R1228Q	0.43
SARC	chr2	210660512	Nonsense_Mutation	NA	R1262*	0.38
SARC	chr2	210675769	Missense_Mutation	novel	N1401K	0.11
SKCM	chr2	210677036	Missense_Mutation	novel	V1435A	0.19
SKCM	chr2	210595512	Missense_Mutation	NA	S430L	0.39
SKCM	chr2	210677111	Missense_Mutation	novel	G1460E	0.67
SKCM	chr2	210582672	Missense_Mutation	NA	P195Q	0.25
SKCM	chr2	210577502	Missense_Mutation	novel	E155K	0.43
SKCM	chr2	210637830	Missense_Mutation	novel	P939L	0.36
SKCM	chr2	210660632	Missense_Mutation	NA	P1302S	0.29
SKCM	chr2	210608448	Silent	NA	A760A	0.4
SKCM	chr2	210602295	Missense_Mutation	novel	P601S	0.36
SKCM	chr2	210654067	Missense_Mutation	novel	E1175K	0.29
SKCM	chr2	210677949	Silent	NA	F1489F	0.27
SKCM	chr2	210573392	Missense_Mutation	NA	N74I	0.18
SKCM	chr2	210591955	Missense_Mutation	rs149930500	D358N	0.2
SKCM	chr2	210658675	Missense_Mutation	NA	G1248E	0.09
SKCM	chr2	210677071	Missense_Mutation	NA	H1447Y	0.19
SKCM	chr2	210647986	Missense_Mutation	NA	R1089C	0.23
SKCM	chr2	210658628	Silent	novel	K1232K	0.58
SKCM	chr2	210658629	Missense_Mutation	novel	A1233S	0.59
SKCM	chr2	210654065	Missense_Mutation	rs553145464	R1174Q	0.25
SKCM	chr2	210591902	Missense_Mutation	novel	A340V	0.39
SKCM	chr2	210556820	Nonsense_Mutation	novel	W29*	0.32
SKCM	chr2	210608436	Silent	novel	G756G	0.28
SKCM	chr2	210608432	Missense_Mutation	NA	S755F	0.44
SKCM	chr2	210608466	Silent	NA	L766L	0.2
SKCM	chr2	210606751	Missense_Mutation	NA	P668S	0.53
SKCM	chr2	210647970	Silent	rs751008875	I1083I	0.17
SKCM	chr2	210658675	Missense_Mutation	NA	G1248E	0.13
SKCM	chr2	210677070	Silent	NA	V1446V	0.17
SKCM	chr2	210606926	Missense_Mutation	NA	A726V	0.34
SKCM	chr2	210573351	Silent	NA	S60S	0.09
SKCM	chr2	210648522	Missense_Mutation	NA	R1129K	0.05
SKCM	chr2	210677923	Missense_Mutation	rs138125466	R1481C	0.05
SKCM	chr2	210588079	Missense_Mutation	NA	G215R	0.25
SKCM	chr2	210595512	Missense_Mutation	NA	S430L	0.21
SKCM	chr2	210677006	Splice_Site	NA	X1425_splice	0.35
SKCM	chr2	210606862	Missense_Mutation	NA	P705S	0.15
SKCM	chr2	210663136	Missense_Mutation	NA	S1314F	0.21
SKCM	chr2	210573392	Missense_Mutation	NA	N74I	0.42
SKCM	chr2	210592908	Silent	rs200465544	F372F	0.45
SKCM	chr2	210675832	Silent	NA	S1422S	0.13
SKCM	chr2	210668210	Missense_Mutation	NA	H1343Y	0.1
SKCM	chr2	210650394	Missense_Mutation	novel	D1146N	0.21
SKCM	chr2	210616450	Missense_Mutation	novel	E866K	0.33
SKCM	chr2	210674922	Silent	novel	F1374F	0.51
SKCM	chr2	210594558	Silent	NA	T405T	0.4
SKCM	chr2	210677909	Missense_Mutation	NA	A1476V	0.54
SKCM	chr2	210606842	Missense_Mutation	novel	N698S	0.24
SKCM	chr2	210658659	Nonsense_Mutation	novel	Q1243*	0.18
SKCM	chr2	210677950	Missense_Mutation	NA	H1490Y	0.71
SKCM	chr2	210650391	Missense_Mutation	NA	E1145K	0.4
SKCM	chr2	210556651	5'UTR	novel		0.56
SKCM	chr2	210647986	Missense_Mutation	NA	R1089C	0.42
SKCM	chr2	210660573	Missense_Mutation	NA	V1282E	0.28
SKCM	chr2	210590894	Missense_Mutation	NA	S312F	0.33
SKCM	chr2	210590895	Silent	novel	S312S	0.33
STAD	chr2	210675763	Silent	rs548201746	N1399N	0.19
STAD	chr2	210677897	Missense_Mutation	NA	L1472R	0.31
STAD	chr2	210576392	Missense_Mutation	novel	T95A	0.15
STAD	chr2	210599504	Missense_Mutation	NA	A498T	0.4
STAD	chr2	210599559	Missense_Mutation	novel	C516F	0.07
STAD	chr2	210577439	Silent	NA	L134L	0.26
STAD	chr2	210600648	Missense_Mutation	NA	Q548P	0.09
STAD	chr2	210637776	Missense_Mutation	novel	L921R	0.41
STAD	chr2	210606764	Missense_Mutation	NA	L672P	0.27
STAD	chr2	210675763	Silent	rs548201746	N1399N	0.32
STAD	chr2	210602254	Missense_Mutation	NA	R587H	0.23
STAD	chr2	210647930	Missense_Mutation	NA	K1070R	0.28
STAD	chr2	210556692	5'UTR	novel		0.4
STAD	chr2	210602217	Missense_Mutation	NA	K575Q	0.29
STAD	chr2	210606815	Missense_Mutation	rs201256385	R689H	0.38
STAD	chr2	210642541	Missense_Mutation	NA	L1006R	0.15
STAD	chr2	210599455	Silent	novel	T481T	0.26
STAD	chr2	210600587	Nonsense_Mutation	novel	E528*	0.07
STAD	chr2	210674912	Missense_Mutation	rs765106604	R1371Q	0.48
STAD	chr2	210600673	Silent	NA	E556E	0.34
STAD	chr2	210605155	Missense_Mutation	NA	K630N	0.2
STAD	chr2	210608492	Missense_Mutation	rs766970243	R775H	0.14
STAD	chr2	210675805	Silent	NA	Q1413Q	0.14
STAD	chr2	210647970	Silent	rs751008875	I1083I	0.27
STAD	chr2	210642513	Missense_Mutation	NA	V997F	0.34
STAD	chr2	210606814	Missense_Mutation	rs147443001	R689C	0.34
STAD	chr2	210608426	Missense_Mutation	NA	V753A	0.05
STAD	chr2	210637748	Missense_Mutation	NA	F912I	0.17
STAD	chr2	210647907	Missense_Mutation	NA	N1062K	0.21
THCA	chr2	210592879	Missense_Mutation	novel	G363R	0.29
THCA	chr2	210592880	Missense_Mutation	novel	G363E	0.3
THCA	chr2	210612278	Frame_Shift_Ins	novel	*Y852Ffs35**	0.05
THCA	chr2	210612280	Nonsense_Mutation	novel	Y852delins*	0.05
UCEC	chr2	210605177	Nonsense_Mutation	rs759201450	R638*	0.28
UCEC	chr2	210647986	Missense_Mutation	NA	R1089C	0.36
UCEC	chr2	210647987	Missense_Mutation	NA	R1089H	0.33
UCEC	chr2	210605218	Missense_Mutation	NA	E651D	0.25
UCEC	chr2	210637724	Missense_Mutation	NA	L904M	0.26
UCEC	chr2	210658665	Missense_Mutation	NA	L1245I	0.2
UCEC	chr2	210674911	Missense_Mutation	rs373056604	R1371W	0.33
UCEC	chr2	210602330	Missense_Mutation	novel	K612N	0.37
UCEC	chr2	210608532	Silent	novel	I788I	0.33
UCEC	chr2	210650393	Missense_Mutation	novel	E1145D	0.33
UCEC	chr2	210608393	Missense_Mutation	novel	A742V	0.43
UCEC	chr2	210599461	Nonsense_Mutation	NA	Y483*	0.26
UCEC	chr2	210639180	Missense_Mutation	rs756163174	V954L	0.46
UCEC	chr2	210660535	Missense_Mutation	NA	K1269N	0.43
UCEC	chr2	210677089	Missense_Mutation	NA	R1453W	0.45
UCEC	chr2	210648534	Missense_Mutation	NA	V1133A	0.06
UCEC	chr2	210660640	Frame_Shift_Ins	novel	*Y1305Rfs9**	0.05
UCEC	chr2	210642553	Missense_Mutation	rs79627159	T1010M	0.45
UCEC	chr2	210639996	Missense_Mutation	NA	E966K	0.25
UCEC	chr2	210650434	Missense_Mutation	novel	S1159Y	0.25
UCEC	chr2	210588134	Missense_Mutation	rs751029486	R233H	0.2
UCEC	chr2	210647943	Silent	novel	K1074K	0.07
UCEC	chr2	210592937	Missense_Mutation	NA	P382Q	0.26
UCEC	chr2	210612239	Missense_Mutation	NA	D838E	0.13
UCEC	chr2	210637722	Missense_Mutation	novel	T903I	0.05
UCEC	chr2	210556843	Missense_Mutation	NA	R37M	0.16
UCEC	chr2	210660640	Frame_Shift_Ins	novel	*Y1305Rfs23**	0.04
UCEC	chr2	210582682	Missense_Mutation	novel	Q198H	0.4
UCEC	chr2	210654067	Nonsense_Mutation	novel	E1175*	0.26
UCEC	chr2	210477720	5'UTR	novel		0.06
UCEC	chr2	210573399	Silent	novel	G76G	0.35
UCEC	chr2	210579762	Missense_Mutation	NA	R174W	0.23
UCEC	chr2	210605125	Missense_Mutation	novel	I620M	0.32
UCEC	chr2	210573347	Missense_Mutation	novel	Y59C	0.31
UCEC	chr2	210591883	Missense_Mutation	novel	A334T	0.16
UCEC	chr2	210592887	Missense_Mutation	novel	M365I	0.24
UCEC	chr2	210582621	Missense_Mutation	novel	T178N	0.34
UCEC	chr2	210595497	Missense_Mutation	novel	V425A	0.49
UCEC	chr2	210599449	Silent	rs80261173	A479A	0.34
UCEC	chr2	210612133	Missense_Mutation	novel	R803H	0.14
UCEC	chr2	210650402	Frame_Shift_Ins	novel	*F1151Ifs7**	0.29
UCEC	chr2	210600602	Missense_Mutation	novel	V533I	0.06
UCEC	chr2	210660640	In_Frame_Ins	novel	D1304_Y1305insR	0.04
UCEC	chr2	210556692	5'UTR	novel		0.41
UCEC	chr2	210599398	Missense_Mutation	novel	M462I	0.16
UCEC	chr2	210556694	5'UTR	novel		0.42
UCEC	chr2	210595560	Missense_Mutation	novel	S446F	0.29
UCEC	chr2	210677918	Missense_Mutation	novel	K1479T	0.49
UCEC	chr2	210605229	Missense_Mutation	NA	A655V	0.48
UCEC	chr2	210612160	Missense_Mutation	novel	A812V	0.48
UCEC	chr2	210642578	Missense_Mutation	novel	E1018D	0.4
UCEC	chr2	210660640	In_Frame_Ins	novel	D1304_Y1305insR	0.15
UCEC	chr2	210660641	Frame_Shift_Ins	novel	*Y1305Ffs17**	0.14
UCEC	chr2	210612165	Missense_Mutation	rs772782772	R814W	0.25
UCEC	chr2	210590167	Missense_Mutation	novel	G258V	0.39
UCEC	chr2	210590123	Missense_Mutation	NA	H243Q	0.46
UCEC	chr2	210595486	Splice_Site	NA	X422_splice	0.44
UCEC	chr2	210605223	In_Frame_Ins	novel	V653_D654insIS	0.11
UCEC	chr2	210594540	Missense_Mutation	novel	K399N	0.57
UCEC	chr2	210612231	Missense_Mutation	novel	N836D	0.35
UCEC	chr2	210606907	Frame_Shift_Del	novel	*S720Afs22**	0.22
UCEC	chr2	210602306	Missense_Mutation	novel	E604D	0.27
UCEC	chr2	210675760	Silent	novel	L1398L	0.11
UCEC	chr2	210647868	Missense_Mutation	novel	C1049W	0.32
UCEC	chr2	210660543	Missense_Mutation	novel	G1272E	0.22
UCEC	chr2	210660571	Missense_Mutation	novel	K1281N	0.21
UCEC	chr2	210650437	Missense_Mutation	novel	Q1160R	0.37
UCEC	chr2	210595541	Nonsense_Mutation	NA	E440*	0.35
UCEC	chr2	210608528	Missense_Mutation	rs571936934	R787Q	0.25
UCEC	chr2	210477700	5'Flank	novel		0.23
UCEC	chr2	210556681	5'UTR	novel		0.41
UCEC	chr2	210573307	Missense_Mutation	novel	A46S	0.31
UCEC	chr2	210606935	Missense_Mutation	novel	A729D	0.43
UCEC	chr2	210582709	Missense_Mutation	novel	K207N	0.39
UCEC	chr2	210642630	Missense_Mutation	novel	S1036P	0.35
UCEC	chr2	210556813	Frame_Shift_Del	novel	*K28Nfs29**	0.24
UCEC	chr2	210677130	Frame_Shift_Del	novel	*Q1468Rfs2**	0.5
UCEC	chr2	210660640	Frame_Shift_Ins	novel	*Y1305Rfs24**	0.05
UCEC	chr2	210556672	5'UTR	novel		0.23
UCEC	chr2	210576389	Missense_Mutation	novel	L94I	0.04
UCEC	chr2	210650387	Missense_Mutation	novel	F1143L	0.18
UCEC	chr2	210675763	Silent	rs548201746	N1399N	0.4
UCEC	chr2	210606794	Missense_Mutation	rs778764720	R682H	0.31
UCEC	chr2	210654082	Missense_Mutation	rs776047286	A1180T	0.47
UCEC	chr2	210616499	Missense_Mutation	rs188120172	R882H	0.28
UCEC	chr2	210608560	Splice_Site	novel	X797_splice	0.26
UCEC	chr2	210599448	Missense_Mutation	rs187860166	A479V	0.21
UCEC	chr2	210477716	5'UTR	novel		0.38
UCEC	chr2	210573307	Missense_Mutation	NA	A46T	0.38
UCEC	chr2	210576455	Missense_Mutation	NA	G116R	0.35
UCEC	chr2	210577505	Nonsense_Mutation	NA	E156*	0.49
UCEC	chr2	210594576	Silent	rs779447126	P411P	0.55
UCEC	chr2	210605177	Nonsense_Mutation	rs759201450	R638*	0.53
UCEC	chr2	210606869	Nonsense_Mutation	novel	S707*	0.19
UCEC	chr2	210677998	3'UTR	novel		0.13
UCEC	chr2	210588134	Missense_Mutation	rs751029486	R233H	0.2
UCEC	chr2	210590848	Missense_Mutation	novel	N297D	0.31
UCEC	chr2	210600617	Missense_Mutation	rs761343774	V538I	0.17
UCEC	chr2	210612133	Missense_Mutation	novel	R803H	0.26
UCEC	chr2	210642568	Missense_Mutation	novel	C1015Y	0.22
UCEC	chr2	210658607	Silent	novel	D1225D	0.34
UCEC	chr2	210608424	Silent	rs770788292	N752N	0.25
UCEC	chr2	210647936	Missense_Mutation	novel	G1072D	0.05
UCEC	chr2	210650368	Missense_Mutation	NA	S1137Y	0.09
UCEC	chr2	210668234	Missense_Mutation	novel	L1351I	0.33
UCEC	chr2	210579762	Missense_Mutation	NA	R174W	0.42
UCEC	chr2	210606902	Missense_Mutation	novel	R718I	0.4
UCS	chr2	210600636	Missense_Mutation	rs121912592	T544M	0.37
UCS	chr2	210605122	Silent	novel	Q619Q	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
MESO	DEL	0.1264	0.014499
PAAD	AMP	0.0815	0.1091
PAAD	DEL	0.038	0.2014

Survival Analysis

Cancer	P-value	Q-value
THYM	0.046	Kaplan-Meier Survival Analysis
MESO	0.00018	Kaplan-Meier Survival Analysis
SKCM	0.032	Kaplan-Meier Survival Analysis
PRAD	0.023	Kaplan-Meier Survival Analysis
KIRP	0.0056	Kaplan-Meier Survival Analysis
BLCA	0.036	Kaplan-Meier Survival Analysis
CESC	0.049	Kaplan-Meier Survival Analysis
READ	0.011	Kaplan-Meier Survival Analysis
KICH	0.0039	Kaplan-Meier Survival Analysis
UCEC	0.0001	Kaplan-Meier Survival Analysis
GBM	0.0063	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.032	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis
OV	0.017	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000021826 (Gene tree)
Gene ID: 1373
Gene Symbol: CPS1
Alias: N
Full Name: carbamoyl-phosphate synthase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 201,426 bases
Position: chr2:210,477,682-210,679,107
Accession: 2323
RBP type: non-canonical RBP
Summary: The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.[provided by RefSeq, May 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000523702	CPS1-211	546	-	ENSP00000430644	157 (aa)	-	E7EWJ3
ENST00000619804	CPS1-212	1542	-	ENSP00000480517	513 (aa)	-	Q5R211
ENST00000497121	CPS1-208	585	-	-	- (aa)	-	-
ENST00000479988	CPS1-207	4811	-	-	- (aa)	-	-
ENST00000451903	CPS1-204	4770	-	ENSP00000406136	1049 (aa)	-	P31327
ENST00000467353	CPS1-205	323	-	-	- (aa)	-	-
ENST00000233072	CPS1-201	5821	-	ENSP00000233072	1500 (aa)	-	P31327
ENST00000518043	CPS1-210	585	-	ENSP00000430697	121 (aa)	-	C9JTA4
ENST00000497163	CPS1-209	443	-	-	- (aa)	-	-
ENST00000417946	CPS1-202	699	-	ENSP00000388496	121 (aa)	-	C9JTA4
ENST00000645825	CPS1-213	2180	-	-	- (aa)	-	-
ENST00000430249	CPS1-203	5698	-	ENSP00000402608	1506 (aa)	-	P31327
ENST00000470791	CPS1-206	501	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000021826's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00220	Arginine biosynthesis	KEGG
hsa00250	Alanine, aspartate and glutamate metabolism	KEGG
hsa00910	Nitrogen metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG
hsa01230	Biosynthesis of amino acids	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000021826	Potassium	0.0001	-
ENSG00000021826	gamma-Glutamyltransferase	7.753e-005	-
ENSG00000021826	alpha-Tocopherol	2.5050000E-005	-
ENSG00000021826	Fibrinogen	2E-11	23969696
ENSG00000021826	Body Mass Index	7E-6	25673413
ENSG00000021826	Amino Acids	3E-11	26068415
ENSG00000021826	Metabolism	3E-11	26068415
ENSG00000021826	Fibrinogen	9E-14	28107422
ENSG00000021826	Fibrinogen	2E-13	28107422
ENSG00000021826	Metabolism	4E-16	24816252
ENSG00000021826	Metabolism	2E-16	24816252
ENSG00000021826	Metabolism	2E-19	24816252
ENSG00000021826	Metabolism	3E-21	24816252
ENSG00000021826	Metabolism	1E-24	24816252
ENSG00000021826	Metabolism	7E-35	24816252
ENSG00000021826	Metabolism	7E-58	24816252
ENSG00000021826	Body Mass Index	9E-6	23517042
ENSG00000021826	Macular Degeneration	1E-15	28250457
ENSG00000021826	Angiography	1E-8	26822151
ENSG00000021826	Betaine	1E-8	26822151
ENSG00000021826	Metabolism	2E-147	24816252
ENSG00000021826	Body Mass Index	4E-6	25673413
ENSG00000021826	Amino Acids	1E-300	27005778
ENSG00000021826	Metabolism	1E-300	27005778
ENSG00000021826	Proteins	1E-300	27005778
ENSG00000021826	Urine	3E-25	26352407
ENSG00000021826	Glomerular Filtration Rate	1E-11	27588450
ENSG00000021826	Homocysteine	9E-13	24651765
ENSG00000021826	Insulin Resistance	3E-50	23378610
ENSG00000021826	Cholesterol, HDL	9E-10	24097068
ENSG00000021826	Fibrinogen	4E-16	26561523
ENSG00000021826	Urine	8E-31	26352407

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000021826	rs1047891	2	210675783	A	Mean corpuscular hemoglobin	27863252	[0.017-0.032] unit increase	0.02438928	EFO_0004527
ENSG00000021826	rs1047891	2	210675783	A	Mean corpuscular volume	27863252	[0.017-0.032] unit increase	0.02424476	EFO_0004526
ENSG00000021826	rs1047891	2	210675783	A	Mean platelet volume	27863252	[0.021-0.037] unit increase	0.02899955	EFO_0004584
ENSG00000021826	rs1047891	2	210675783	A	Serum metabolite concentrations in chronic kidney disease	29545352	[0.31-0.48] unit increase	0.394115	EFO_0003884\|EFO_0005653
ENSG00000021826	rs1047891	2	210675783	?	Alanine transaminase levels	29403010	[0.038-0.06] unit increase	0.049	EFO_0004735
ENSG00000021826	rs1047891	2	210675783	A	Metabolite levels (small molecules and protein measures)	27005778	[0.47-0.51] unit increase	0.49	EFO_0005664\|EFO_0004747\|EFO_0005134
ENSG00000021826	rs7422339	2	210675783	A	Chronic kidney disease	20383146	[0.005-0.013] unit decrease	0.01	EFO_0003884\|EFO_0004518
ENSG00000021826	rs715	2	210678331	C	Glomerular filtration rate	27588450	[0.63-1.12] unit decrease	0.876	EFO_0005208
ENSG00000021826	rs7422339	2	210675783	A	Glomerular filtration rate in non diabetics (creatinine)	26831199	[0.0084-0.0128] unit decrease	0.0106	EFO_0005208\|EFO_0004518
ENSG00000021826	rs715	2	210678331	T	Metabolite levels	23378610	[0.53-0.69] unit decrease	0.61	EFO_0004471
ENSG00000021826	rs715	2	210678331	T	Fibrinogen	23969696	[0.007-0.011] unit increase	0.009	EFO_0004623
ENSG00000021826	rs1047891	2	210675783	A	HDL cholesterol	24097068	[NR] unit decrease	0.027	EFO_0004612
ENSG00000021826	rs715	2	210678331	C	Fibrinogen levels	26561523	NR unit decrease	0.0082	EFO_0004623
ENSG00000021826	rs715	2	210678331	C	Betaine levels in individuals undergoing cardiac evaluation	26822151	[0.032-0.068] unit decrease	0.05	EFO_0007787\|EFO_0006512
ENSG00000021826	rs7422339	2	210675783	A	Chronic kidney disease	26831199	[1.07-1.15]	1.11	EFO_0003884
ENSG00000021826	rs715	2	210678331	T	Amino acid levels	26068415	[0.022-0.04] unit decrease	0.0311	EFO_0005664\|EFO_0005134
ENSG00000021826	rs7422339	2	210675783	A	Glomerular filtration rate (creatinine)	26831199	[0.0086-0.0126] unit decrease	0.0106	EFO_0005208\|EFO_0004518
ENSG00000021826	rs715	2	210678331	C	Urinary metabolites	26352407	[NR] unit increase	0.1409	EFO_0005116
ENSG00000021826	rs715	2	210678331	C	Urinary metabolites	26352407	[NR] unit increase	0.176	EFO_0005116
ENSG00000021826	rs7422339	2	210675783	A	Homocysteine levels	23824729	[0.071-0.102] unit increase	0.0864	EFO_0004578
ENSG00000021826	rs12468557	2	210630863	T	Body mass index in asthmatics	23517042			EFO_0004340
ENSG00000021826	rs1047891	2	210675783	A	Plasma homocysteine levels (post-methionine load test)	24651765	[0.12-0.26] unit increase	0.191	EFO_0004578
ENSG00000021826	rs7422339	2	210675783	A	Fibrinogen	20031577	[NR] mg/dl decrease	4.84	EFO_0004623
ENSG00000021826	rs7422339	2	210675783	A	Homocysteine levels	20154341	[0.03-0.07] log(Hcy) increase	0.05	EFO_0004578
ENSG00000021826	rs7422339	2	210675783	A	Serum metabolite levels	24625756	[NR] unit increase	0.1	EFO_0005653
ENSG00000021826	rs715	2	210678331	T	Blood metabolite levels	24816252	[0.07-0.082] unit decrease	0.076	EFO_0005664
ENSG00000021826	rs715	2	210678331	T	Blood metabolite levels	24816252	[0.079-0.103] unit decrease	0.091	EFO_0005664
ENSG00000021826	rs715	2	210678331	T	Blood metabolite levels	24816252	[0.027-0.039] unit decrease	0.033	EFO_0005664
ENSG00000021826	rs715	2	210678331	T	Blood metabolite levels	24816252	[0.037-0.053] unit decrease	0.045	EFO_0005664
ENSG00000021826	rs715	2	210678331	T	Blood metabolite levels	24816252	[0.018-0.026] unit decrease	0.022	EFO_0005664
ENSG00000021826	rs715	2	210678331	T	Blood metabolite levels	24816252	[0.016-0.028] unit increase	0.022	EFO_0005664
ENSG00000021826	rs715	2	210678331	T	Blood metabolite levels	24816252	[0.028-0.044] unit increase	0.036	EFO_0005664
ENSG00000021826	rs715	2	210678331	T	Blood metabolite levels	24816252	[0.016-0.028] unit increase	0.022	EFO_0005664
ENSG00000021826	rs715	2	210678331	?	Creatinine levels	29403010	[0.027-0.047] unit increase novel	0.03693	EFO_0004518
ENSG00000021826	rs1047891	2	210675783	?	Mean corpuscular volume	29403010	[0.023-0.047] unit increase novel	0.03507	EFO_0004526
ENSG00000021826	rs1047891	2	210675783	?	Mean corpuscular hemoglobin	29403010	[0.022-0.047] unit increase novel	0.0346	EFO_0004527
ENSG00000021826	rs1047891	2	210675783	A	Glomerular filtration rate (creatinine)	28452372	[0.0069-0.0109] unit decrease	0.0089	EFO_0005208\|EFO_0004518
ENSG00000021826	rs715	2	210678331	C	Plateletcrit	27863252	[0.016-0.032] unit decrease	0.02410037	EFO_0007985
ENSG00000021826	rs1047891	2	210675783	A	Platelet count	27863252	[0.027-0.042] unit decrease	0.03416632	EFO_0004309
ENSG00000021826	rs715	2	210678331	C	Eosinophil percentage of granulocytes	27863252	[0.015-0.031] unit increase	0.0230721	EFO_0007996
ENSG00000021826	rs715	2	210678331	?	Macular telangiectasia type 2	28250457	[1.64-2.27]	1.923077	EFO_1002009
ENSG00000021826	rs715	2	210678331	?	Fibrinogen levels	28107422	unit increase	0.0092	EFO_0004623
ENSG00000021826	rs715	2	210678331	?	Fibrinogen levels	28107422	unit increase	0.0082	EFO_0004623
ENSG00000021826	rs715	2	210678331	C	Eosinophil percentage of white cells	27863252	[0.017-0.032] unit increase	0.02420978	EFO_0007991
ENSG00000021826	rs1047891	2	210675783	C	Urinary albumin excretion	30220432	[0.0085-0.0156] unit increase	0.01205	EFO_0004285
ENSG00000021826	rs1047891	2	210675783	C	Urinary albumin excretion (no hypertensive medication)	30220432	[0.0066-0.014] unit increase	0.01031	EFO_0004285
ENSG00000021826	rs187097936	2	210498225	C	Blood protein levels	30072576	[0.58-0.98] unit increase	0.781	EFO_0007937
ENSG00000021826	rs715	2	210678331	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000021826	rs1047891	2	210675783	?	White blood cell count	30595370			EFO_0004308
ENSG00000021826	rs1047891	2	210675783	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000021826	rs1047891	2	210675783	C	Systolic blood pressure	30224653	[0.19-0.32] mmHg increase	0.2528	EFO_0006335
ENSG00000021826	rs1047891	2	210675783	A	Estimated glomerular filtration rate	30604766	[0.4-0.82] ml/min/1.73m2 decrease	0.61	EFO_0005208
ENSG00000021826	rs1047891	2	210675783	?	Fat-free mass	30593698	[0.1-0.2] unit increase	0.15189	EFO_0004995
ENSG00000021826	rs1047891	2	210675783	?	Fat-free mass	30593698	[0.12-0.27] unit increase	0.19194	EFO_0004995
ENSG00000021826	rs1047891	2	210675783	?	Fat-free mass	30593698	[0.13-0.22] unit increase	0.17494	EFO_0004995
ENSG00000021826	rs715	2	210678331	?	Eosinophil counts	30595370			EFO_0004842
ENSG00000021826	rs1047891	2	210675783	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000021826	rs715	2	210678331	T	Plasma free amino acid levels (adjusted for twenty other PFAAs)	30659259	[0.64-0.8] unit increase	0.72	EFO_0009767\|EFO_0005134

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000021826's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000050	urea cycle	1840546.	NAS	Process
GO:0000050	urea cycle	-	TAS	Process
GO:0004087	carbamoyl-phosphate synthase (ammonia) activity	6249820.	EXP	Function
GO:0004087	carbamoyl-phosphate synthase (ammonia) activity	21873635.	IBA	Function
GO:0004087	carbamoyl-phosphate synthase (ammonia) activity	8486760.9711878.	IMP	Function
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	-	IEA	Function
GO:0004175	endopeptidase activity	-	IEA	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	12620389.15161933.20618440.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005543	phospholipid binding	-	IEA	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005743	mitochondrial inner membrane	-	IEA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	-	IEA	Process
GO:0006508	proteolysis	-	IEA	Process
GO:0006526	arginine biosynthetic process	21873635.	IBA	Process
GO:0006541	glutamine metabolic process	-	IEA	Process
GO:0006807	nitrogen compound metabolic process	21873635.	IBA	Process
GO:0007494	midgut development	-	IEA	Process
GO:0010043	response to zinc ion	-	IEA	Process
GO:0014075	response to amine	-	IEA	Process
GO:0016595	glutamate binding	-	IEA	Function
GO:0019240	citrulline biosynthetic process	14718356.	NAS	Process
GO:0019433	triglyceride catabolic process	9711878.	IMP	Process
GO:0032094	response to food	-	IEA	Process
GO:0032496	response to lipopolysaccharide	15897806.	IDA	Process
GO:0032991	protein-containing complex	-	IEA	Component
GO:0042311	vasodilation	14718356.	IMP	Process
GO:0042594	response to starvation	-	IEA	Process
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component
GO:0043200	response to amino acid	-	IEA	Process
GO:0044344	cellular response to fibroblast growth factor stimulus	-	IEA	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0046209	nitric oxide metabolic process	14718356.	IMP	Process
GO:0050667	homocysteine metabolic process	20031578.	IDA	Process
GO:0055081	anion homeostasis	-	IEA	Process
GO:0060416	response to growth hormone	-	IEA	Process
GO:0070365	hepatocyte differentiation	-	IEA	Process
GO:0070409	carbamoyl phosphate biosynthetic process	7416778.21120950.	IMP	Process
GO:0071320	cellular response to cAMP	-	IEA	Process
GO:0071377	cellular response to glucagon stimulus	-	IEA	Process
GO:0071400	cellular response to oleic acid	-	IEA	Process
GO:0071548	response to dexamethasone	-	IEA	Process
GO:0072341	modified amino acid binding	20031578.	IDA	Function
GO:1903718	cellular response to ammonia	21120950.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.