EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
12068296	Truncating mutations of RB1CC1 in human breast cancer.	Nat Genet	2002 Jul	Chano T	-
21602932	Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity.	PLoS One	2011	Wang D	doi: 10.1371/journal.pone.0019629
12163359	Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells.	Am J Pathol	2002 Aug	Chano T	-
22751121	FIP200 inhibits β-catenin-mediated transcription by promoting APC-independent β-catenin ubiquitination.	Oncogene	2013 May 9	Choi JD	doi: 10.1038/onc.2012.262
24732589	Tumor-suppressive functions of 15-Lipoxygenase-2 and RB1CC1 in prostate cancer.	Cell Cycle	2014	Suraneni MV	doi: 10.4161/cc.28757
19437535	RB1CC1 activates the promoter and expression of RB1 in human cancer.	Int J Cancer	2009 Aug 15	Ikebuchi K	doi: 10.1002/ijc.24466.
21203526	RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients.	PLoS One	2010 Dec 22	Chano T	doi: 10.1371/journal.pone.0015737.
26829385	MiR-20a and miR-20b negatively regulate autophagy by targeting RB1CC1/FIP200 in breast cancer cells.	Life Sci	2016 Feb 15	Li S	doi: 10.1016/j.lfs.2016.01.044
16061648	Mechanism of cell cycle regulation by FIP200 in human breast cancer cells.	Cancer Res	2005 Aug 1	Melkoumian ZK	-
24610824	Identification of miR-133b and RB1CC1 as independent predictors for biochemical recurrence and potential therapeutic targets for prostate cancer.	Clin Cancer Res	2014 May 1	Li X	doi: 10.1158/1078-0432.CCR-13-1588
18036779	FIP200, a key signaling node to coordinately regulate various cellular processes.	Cell Signal	2008 May	Gan B	-
27615604	miR-224-3p inhibits autophagy in cervical cancer cells by targeting FIP200.	Sci Rep	2016 Sep 12	Fang W	doi: 10.1038/srep33229.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr8	52657074	Nonsense_Mutation	novel	E919*	0.16
BLCA	chr8	52661152	Silent	NA	Y496Y	0.2
BLCA	chr8	52657361	Missense_Mutation	novel	R823T	0.06
BLCA	chr8	52661596	Missense_Mutation	rs750998543	I433V	0.06
BLCA	chr8	52656691	Silent	novel	L1046L	0.28
BLCA	chr8	52657693	Silent	novel	Q712Q	0.07
BLCA	chr8	52656273	Nonsense_Mutation	novel	E1186*	0.42
BLCA	chr8	52674206	Missense_Mutation	NA	R214T	0.06
BLCA	chr8	52656091	Silent	NA	L1246L	0.4
BLCA	chr8	52685439	Missense_Mutation	novel	G11R	0.04
BLCA	chr8	52628131	Missense_Mutation	novel	E1513K	0.27
BLCA	chr8	52656186	Missense_Mutation	novel	D1215H	0.32
BLCA	chr8	52642362	Missense_Mutation	novel	M1442I	0.24
BLCA	chr8	52645853	Missense_Mutation	NA	S1279F	0.29
BLCA	chr8	52656841	Missense_Mutation	novel	Q996H	0.31
BLCA	chr8	52656192	Missense_Mutation	novel	E1213K	0.28
BLCA	chr8	52657170	Missense_Mutation	novel	E887Q	0.22
BLCA	chr8	52657508	Missense_Mutation	novel	S774N	0.58
BLCA	chr8	52657144	Silent	novel	L895L	0.23
BLCA	chr8	52628132	Missense_Mutation	novel	D1512E	0.36
BLCA	chr8	52657463	Missense_Mutation	novel	G789E	0.43
BLCA	chr8	52642738	Missense_Mutation	novel	L1354F	0.07
BLCA	chr8	52658075	Missense_Mutation	novel	L615I	0.08
BLCA	chr8	52661596	Missense_Mutation	rs750998543	I433V	0.8
BLCA	chr8	52642521	Silent	novel	V1389V	0.21
BRCA	chr8	52657292	Missense_Mutation	NA	N846S	0.35
BRCA	chr8	52657093	Nonsense_Mutation	novel	*E912Dfs5**	0.08
BRCA	chr8	52683721	Splice_Site	NA	X67_splice	0.29
BRCA	chr8	52656630	Nonsense_Mutation	NA	K1067*	0.3
BRCA	chr8	52636063	Silent	NA	N1448N	0.37
BRCA	chr8	52623704	3'UTR	novel		0.23
BRCA	chr8	52673855	Missense_Mutation	rs145052579	S331F	0.17
BRCA	chr8	52622897	3'UTR	novel		0.08
BRCA	chr8	52657823	Missense_Mutation	NA	R669I	0.4
BRCA	chr8	52656316	Frame_Shift_Ins	NA	*N1171Kfs8**	0.21
BRCA	chr8	52676398	Silent	NA	S181S	0.13
BRCA	chr8	52674218	Missense_Mutation	novel	R210K	0.11
BRCA	chr8	52645767	Missense_Mutation	NA	E1308K	0.26
BRCA	chr8	52642805	Missense_Mutation	novel	F1332C	0.04
BRCA	chr8	52656401	Missense_Mutation	NA	R1143I	0.13
BRCA	chr8	52668158	Missense_Mutation	novel	E346K	0.05
BRCA	chr8	52656082	Frame_Shift_Ins	novel	*F1249Lfs15**	0.01
BRCA	chr8	52657761	In_Frame_Ins	novel	E689_L690insVLFDVFLLV	0.07
BRCA	chr8	52660984	Frame_Shift_Ins	novel	*D523Efs29**	0.05
BRCA	chr8	52661104	Nonsense_Mutation	novel	*H512_Y513insMEFSHGKMFIKH**	0.06
BRCA	chr8	52673864	Missense_Mutation	novel	C328F	0.1
BRCA	chr8	52630497	Missense_Mutation	NA	R1491K	0.35
CESC	chr8	52657880	Missense_Mutation	novel	S650C	0.43
CESC	chr8	52657328	Nonsense_Mutation	NA	S834*	0.24
CESC	chr8	52674168	Missense_Mutation	NA	E227Q	0.26
CESC	chr8	52623661	3'UTR	novel		0.59
CESC	chr8	52674129	Missense_Mutation	novel	L240M	0.07
CESC	chr8	52657767	Missense_Mutation	NA	E688K	0.25
CESC	chr8	52657900	Silent	NA	V643V	0.29
CESC	chr8	52660942	Silent	novel	S537S	0.29
CESC	chr8	52673904	Nonsense_Mutation	novel	Q315*	0.65
CESC	chr8	52685399	Missense_Mutation	novel	T24I	0.39
CESC	chr8	52622796	3'UTR	novel		0.28
CESC	chr8	52642559	Missense_Mutation	rs375185081	R1377C	0.27
CESC	chr8	52656045	Missense_Mutation	novel	E1262Q	0.36
CESC	chr8	52668041	Missense_Mutation	novel	E385K	0.32
CESC	chr8	52623589	3'UTR	novel		0.5
CESC	chr8	52623711	3'UTR	novel		0.15
CHOL	chr8	52656093	Silent	novel	L1246L	0.47
CHOL	chr8	52642373	Missense_Mutation	novel	E1439Q	0.52
COAD	chr8	52673935	Frame_Shift_Del	novel	*F304Lfs6**	0.47
COAD	chr8	52668142	Missense_Mutation	NA	I351N	0.26
COAD	chr8	52674234	Silent	novel	L205L	0.1
COAD	chr8	52657154	Missense_Mutation	NA	I892S	0.31
COAD	chr8	52657420	Silent	novel	V803V	0.22
COAD	chr8	52656695	Missense_Mutation	NA	E1045G	0.37
COAD	chr8	52656937	Frame_Shift_Ins	NA	*L965Afs4**	0.35
COAD	chr8	52668151	Missense_Mutation	rs143749402	R348H	0.41
COAD	chr8	52661148	Missense_Mutation	novel	L498V	0.32
COAD	chr8	52656938	Frame_Shift_Del	NA	*K964Sfs13**	0.31
COAD	chr8	52657517	Missense_Mutation	rs753833588	A771V	0.23
COAD	chr8	52657502	Missense_Mutation	rs775302732	R776Q	0.4
COAD	chr8	52660644	Frame_Shift_Ins	novel	*L547Ffs7**	0.05
COAD	chr8	52656214	Nonsense_Mutation	novel	Y1205*	0.45
COAD	chr8	52657213	Frame_Shift_Ins	NA	*N872Kfs2**	0.31
COAD	chr8	52676513	Missense_Mutation	NA	E143A	0.26
COAD	chr8	52661214	Missense_Mutation	rs746797101	V476I	0.22
COAD	chr8	52685399	Missense_Mutation	novel	T24I	0.15
COAD	chr8	52623812	Silent	NA	V1585V	0.2
COAD	chr8	52642414	Missense_Mutation	novel	A1425V	0.05
COAD	chr8	52657268	Missense_Mutation	novel	S854Y	0.04
COAD	chr8	52658033	Missense_Mutation	NA	S629A	0.13
COAD	chr8	52656449	Missense_Mutation	NA	T1127N	0.23
COAD	chr8	52661188	In_Frame_Ins	novel	K484delinsNKHTP	0.08
DLBC	chr8	52642770	Nonsense_Mutation	novel	E1344*	0.37
ESCA	chr8	52673983	Silent	rs747652097	Q288Q	0.27
ESCA	chr8	52642425	Silent	novel	S1421S	0.15
ESCA	chr8	52661623	Missense_Mutation	novel	L424M	0.12
ESCA	chr8	52623019	3'UTR	novel		0.3
ESCA	chr8	52623360	3'UTR	novel		0.12
ESCA	chr8	52657453	Silent	novel	T792T	0.43
GBM	chr8	52656366	Missense_Mutation	novel	L1155I	0.36
GBM	chr8	52658894	Missense_Mutation	rs776111804	S591L	0.23
GBM	chr8	52642559	Missense_Mutation	rs375185081	R1377C	0.47
GBM	chr8	52642437	Silent	novel	L1417L	0.07
GBM	chr8	52674007	Silent	novel	E280E	0.08
GBM	chr8	52628132	Silent	rs375798667	D1512D	0.33
GBM	chr8	52660988	Missense_Mutation	rs766968433	K522R	0.22
GBM	chr8	52673876	Frame_Shift_Del	novel	*L324Wfs9**	0.21
GBM	chr8	52658042	Missense_Mutation	novel	D626N	0.51
GBM	chr8	52656185	Frame_Shift_Del	novel	*K1214Tfs16**	0.36
GBM	chr8	52657230	Missense_Mutation	novel	L867I	0.18
GBM	chr8	52685441	Missense_Mutation	novel	T10N	0.27
GBM	chr8	52657733	Missense_Mutation	NA	T699M	0.36
HNSC	chr8	52658000	Nonsense_Mutation	novel	K640*	0.26
HNSC	chr8	52673990	Missense_Mutation	novel	V286A	0.24
HNSC	chr8	52674145	Frame_Shift_Del	novel	*M234Ifs22**	0.06
HNSC	chr8	52657813	Silent	novel	P672P	0.13
HNSC	chr8	52661220	Missense_Mutation	rs151174558	R474C	0.19
HNSC	chr8	52657001	Missense_Mutation	novel	S943F	0.24
HNSC	chr8	52661136	Missense_Mutation	novel	E502K	0.22
HNSC	chr8	52657230	Missense_Mutation	novel	L867V	0.18
HNSC	chr8	52656804	Missense_Mutation	novel	D1009Y	0.1
HNSC	chr8	52683689	Missense_Mutation	novel	E77Q	0.56
KIRC	chr8	52657404	Missense_Mutation	novel	H809N	0.25
KIRC	chr8	52630526	Missense_Mutation	novel	M1481I	0.3
KIRC	chr8	52673947	Missense_Mutation	NA	D300E	0.59
KIRC	chr8	52642365	Silent	NA	S1441S	0.26
KIRP	chr8	52656274	Silent	novel	S1185S	0.12
KIRP	chr8	52657447	Silent	NA	L794L	0.34
KIRP	chr8	52683896	Silent	novel	S63S	0.28
KIRP	chr8	52642537	Missense_Mutation	NA	K1384T	0.41
LGG	chr8	52657494	Missense_Mutation	rs368359280	D779N	0.26
LGG	chr8	52683640	Missense_Mutation	rs757154137	S93L	0.2
LGG	chr8	52656999	Missense_Mutation	NA	Q944E	0.35
LGG	chr8	52674239	Missense_Mutation	novel	P203Q	0.09
LIHC	chr8	52642558	Missense_Mutation	rs768037976	R1377H	0.29
LIHC	chr8	52683942	Missense_Mutation	rs766400698	N48S	0.49
LIHC	chr8	52628158	Nonsense_Mutation	novel	G1504*	0.51
LIHC	chr8	52628159	Silent	novel	V1503V	0.52
LIHC	chr8	52628170	Splice_Site	NA	X1500_splice	0.3
LIHC	chr8	52623785	Silent	rs145350535	V1594V	0.18
LIHC	chr8	52656965	Missense_Mutation	NA	R955Q	0.04
LIHC	chr8	52660595	Splice_Site	NA	X563_splice	0.7
LUAD	chr8	52628127	Missense_Mutation	novel	R1514L	0.16
LUAD	chr8	52656855	Missense_Mutation	novel	E992K	0.07
LUAD	chr8	52656574	Silent	NA	Q1085Q	0.18
LUAD	chr8	52642390	Missense_Mutation	novel	R1433I	0.09
LUAD	chr8	52634935	Silent	NA	L1476L	0.25
LUAD	chr8	52685482	5'UTR	novel		0.33
LUAD	chr8	52656369	Missense_Mutation	novel	E1154K	0.14
LUAD	chr8	52657039	Frame_Shift_Ins	novel	*D931Gfs17**	0.1
LUAD	chr8	52645797	Nonsense_Mutation	novel	E1298*	0.27
LUAD	chr8	52657211	Missense_Mutation	NA	E873V	0.2
LUAD	chr8	52657670	Missense_Mutation	novel	D720V	0.16
LUAD	chr8	52661203	Silent	novel	L479L	0.35
LUAD	chr8	52628103	Missense_Mutation	NA	T1522S	0.36
LUAD	chr8	52657210	Missense_Mutation	novel	E873D	0.17
LUAD	chr8	52674140	Missense_Mutation	novel	R236I	0.49
LUAD	chr8	52628157	Missense_Mutation	NA	G1504A	0.1
LUAD	chr8	52661166	Missense_Mutation	NA	V492I	0.33
LUAD	chr8	52657548	Missense_Mutation	novel	V761L	0.05
LUAD	chr8	52642717	Silent	NA	Q1361Q	0.38
LUAD	chr8	52673949	Missense_Mutation	rs767469821	D300H	0.24
LUAD	chr8	52657485	Missense_Mutation	novel	V782I	0.28
LUAD	chr8	52683719	Missense_Mutation	novel	D67Y	0.1
LUAD	chr8	52642507	Missense_Mutation	novel	S1394I	0.28
LUAD	chr8	52676431	Silent	NA	K170K	0.13
LUAD	chr8	52645711	Silent	rs749367208	A1326A	0.31
LUSC	chr8	52676526	Missense_Mutation	novel	L139F	0.18
LUSC	chr8	52673853	Missense_Mutation	NA	M332L	0.38
LUSC	chr8	52628128	Missense_Mutation	rs113117391	R1514C	0.21
LUSC	chr8	52642785	Nonsense_Mutation	novel	E1339*	0.19
LUSC	chr8	52658003	Missense_Mutation	novel	Q639K	0.07
LUSC	chr8	52668062	Missense_Mutation	novel	S378C	0.4
LUSC	chr8	52657883	Nonsense_Mutation	novel	Q649delinsLKKLGE*	0.13
LUSC	chr8	52656468	Missense_Mutation	novel	G1121C	0.43
LUSC	chr8	52656829	Silent	novel	I1000I	0.16
LUSC	chr8	52656737	Missense_Mutation	novel	S1031F	0.22
LUSC	chr8	52656006	Splice_Site	NA	X1274_splice	0.52
LUSC	chr8	52660972	Silent	NA	L527L	0.26
LUSC	chr8	52660987	Silent	NA	K522K	0.18
LUSC	chr8	52656143	Missense_Mutation	novel	Q1229R	0.21
LUSC	chr8	52656122	Missense_Mutation	novel	C1236F	0.2
LUSC	chr8	52674069	Nonsense_Mutation	NA	K260*	0.55
LUSC	chr8	52661217	Missense_Mutation	novel	L475F	0.06
LUSC	chr8	52642536	Missense_Mutation	novel	K1384N	0.09
LUSC	chr8	52661248	Silent	novel	Q464Q	0.1
LUSC	chr8	52657680	Missense_Mutation	NA	V717I	0.59
LUSC	chr8	52656888	Nonsense_Mutation	novel	Q981*	0.28
OV	chr8	52657630	Missense_Mutation	NA	M733I	0.07
OV	chr8	52657733	Missense_Mutation	NA	T699M	0.43
OV	chr8	52673900	Missense_Mutation	NA	D316G	0.15
OV	chr8	52642523	In_Frame_Del	rs751297061	E1388del	0.62
OV	chr8	52642526	Nonsense_Mutation	NA	E1388*	0.42
OV	chr8	52674088	Silent	rs756655906	S253S	0.11
OV	chr8	52642529	Nonsense_Mutation	NA	E1387*	0.53
OV	chr8	52642457	Nonsense_Mutation	NA	G1411*	0.51
OV	chr8	52656060	In_Frame_Del	NA	V1256del	0.67
OV	chr8	52660636	Missense_Mutation	NA	R550L	0.09
OV	chr8	52657782	Missense_Mutation	NA	A683T	0.14
PAAD	chr8	52642558	Missense_Mutation	rs768037976	R1377H	0.05
PAAD	chr8	52623698	3'UTR	novel		0.16
PAAD	chr8	52661162	Missense_Mutation	novel	P493H	0.23
PAAD	chr8	52661605	Missense_Mutation	novel	L430M	0.19
PAAD	chr8	52683671	Missense_Mutation	NA	R83C	0.17
PAAD	chr8	52656316	Frame_Shift_Ins	NA	*N1171Kfs8**	0.24
READ	chr8	52636035	Missense_Mutation	novel	R1458W	0.22
READ	chr8	52676487	Missense_Mutation	novel	A152T	0.21
READ	chr8	52656607	Silent	novel	I1074I	0.07
READ	chr8	52645716	Missense_Mutation	rs774629394	I1325V	0.17
READ	chr8	52657359	Missense_Mutation	novel	T824A	0.15
READ	chr8	52685458	Nonsense_Mutation	novel	Y4*	0.16
READ	chr8	52657733	Missense_Mutation	NA	T699M	0.04
READ	chr8	52674191	Missense_Mutation	novel	R219K	0.07
READ	chr8	52657188	Missense_Mutation	NA	L881I	0.45
READ	chr8	52683916	Nonsense_Mutation	NA	R57*	0.42
READ	chr8	52656535	Silent	NA	E1098E	0.53
READ	chr8	52628115	Missense_Mutation	novel	Y1518C	0.11
READ	chr8	52656876	Nonsense_Mutation	novel	Q985*	0.28
SARC	chr8	52622866	3'UTR	novel		0.25
SARC	chr8	52622599	3'UTR	novel		0.41
SKCM	chr8	52660602	Silent	NA	S561S	0.2
SKCM	chr8	52657797	Missense_Mutation	rs747970098	D678N	0.07
SKCM	chr8	52658892	Missense_Mutation	novel	E592K	0.38
SKCM	chr8	52658893	Silent	rs187858160	S591S	0.37
SKCM	chr8	52676499	Nonsense_Mutation	NA	Q148*	0.04
SKCM	chr8	52673879	Missense_Mutation	novel	S323F	0.17
SKCM	chr8	52645767	Missense_Mutation	NA	E1308K	0.43
SKCM	chr8	52661547	Missense_Mutation	novel	H449L	0.52
SKCM	chr8	52623743	3'UTR	novel		0.47
SKCM	chr8	52661136	Nonsense_Mutation	novel	E502*	0.05
SKCM	chr8	52645728	Nonsense_Mutation	NA	R1321*	0.29
SKCM	chr8	52673894	Missense_Mutation	NA	P318L	0.19
SKCM	chr8	52674071	Missense_Mutation	NA	P259L	0.18
SKCM	chr8	52683709	Missense_Mutation	novel	P70L	0.23
SKCM	chr8	52656673	Missense_Mutation	novel	D1052E	0.29
SKCM	chr8	52660943	Missense_Mutation	NA	S537F	0.5
SKCM	chr8	52668053	Nonsense_Mutation	NA	R381*	0.5
SKCM	chr8	52642564	Missense_Mutation	NA	R1375Q	0.38
SKCM	chr8	52657888	Silent	NA	S647S	0.16
SKCM	chr8	52668110	Missense_Mutation	novel	I362F	0.54
SKCM	chr8	52668074	Nonsense_Mutation	NA	Q374*	0.55
SKCM	chr8	52660637	Missense_Mutation	rs770511277	R550C	0.25
SKCM	chr8	52683983	Silent	NA	S34S	0.09
SKCM	chr8	52623765	3'UTR	novel		0.25
SKCM	chr8	52660943	Missense_Mutation	NA	S537F	0.35
SKCM	chr8	52658898	Missense_Mutation	NA	P590S	0.29
STAD	chr8	52683670	Missense_Mutation	NA	R83H	0.22
STAD	chr8	52656317	Frame_Shift_Del	novel	*N1171Tfs2**	0.18
STAD	chr8	52656175	Frame_Shift_Del	novel	*K1218Nfs13**	0.28
STAD	chr8	52660611	Missense_Mutation	novel	W558C	0.12
STAD	chr8	52660612	Missense_Mutation	novel	W558S	0.11
STAD	chr8	52636058	Missense_Mutation	rs775020996	H1450R	0.22
STAD	chr8	52657716	Missense_Mutation	novel	I705V	0.1
STAD	chr8	52661582	Silent	novel	C437C	0.08
STAD	chr8	52657279	Frame_Shift_Del	rs772155322	V851*	0.23
STAD	chr8	52656610	Silent	NA	E1073E	0.17
STAD	chr8	52656317	Frame_Shift_Del	novel	*N1171Tfs2**	0.16
STAD	chr8	52661191	Silent	NA	V483V	0.34
STAD	chr8	52683639	Silent	rs374755456	S93S	0.47
STAD	chr8	52656635	Missense_Mutation	NA	A1065V	0.26
STAD	chr8	52657393	Silent	NA	I812I	0.04
STAD	chr8	52660644	Frame_Shift_Ins	novel	*L547Ffs7**	0.21
STAD	chr8	52628072	Silent	NA	S1532S	0.09
STAD	chr8	52660979	Missense_Mutation	NA	K525T	0.14
STAD	chr8	52656767	Missense_Mutation	novel	N1021T	0.39
STAD	chr8	52656938	Frame_Shift_Del	NA	*K964Sfs13**	0.1
STAD	chr8	52656214	Silent	rs771579613	Y1205Y	0.22
STAD	chr8	52656317	Frame_Shift_Del	novel	*N1171Tfs2**	0.2
STAD	chr8	52656938	Frame_Shift_Del	NA	*K964Sfs13**	0.23
STAD	chr8	52657147	Frame_Shift_Del	novel	*K894Nfs2**	0.26
STAD	chr8	52657996	Splice_Site	novel	X640_splice	0.24
STAD	chr8	52656938	Frame_Shift_Del	NA	*K964Sfs13**	0.27
STAD	chr8	52661214	Missense_Mutation	rs746797101	V476I	0.3
THCA	chr8	52658939	Missense_Mutation	novel	D576G	0.22
THYM	chr8	52656756	Frame_Shift_Del	novel	*N1021Lfs22**	0.11
UCEC	chr8	52623833	Frame_Shift_Ins	novel	*L1578Ffs15**	0.29
UCEC	chr8	52657517	Missense_Mutation	rs753833588	A771V	0.13
UCEC	chr8	52645728	Nonsense_Mutation	NA	R1321*	0.28
UCEC	chr8	52656213	Missense_Mutation	rs569632839	E1206K	0.33
UCEC	chr8	52657393	Missense_Mutation	NA	I812M	0.36
UCEC	chr8	52657890	Missense_Mutation	NA	S647P	0.28
UCEC	chr8	52656034	Silent	NA	K1265K	0.32
UCEC	chr8	52657733	Missense_Mutation	NA	T699M	0.31
UCEC	chr8	52636035	Missense_Mutation	novel	R1458W	0.21
UCEC	chr8	52676373	Missense_Mutation	novel	T190A	0.06
UCEC	chr8	52657133	Missense_Mutation	novel	L899S	0.31
UCEC	chr8	52661205	Silent	novel	L479L	0.48
UCEC	chr8	52683963	Missense_Mutation	novel	Q41R	0.45
UCEC	chr8	52623572	3'UTR	novel		0.37
UCEC	chr8	52661219	Missense_Mutation	rs142146940	R474H	0.42
UCEC	chr8	52683671	Missense_Mutation	NA	R83C	0.48
UCEC	chr8	52622582	3'UTR	novel		0.53
UCEC	chr8	52674110	Missense_Mutation	rs768671411	M246T	0.31
UCEC	chr8	52623496	3'UTR	novel		0.13
UCEC	chr8	52673851	Missense_Mutation	novel	M332I	0.04
UCEC	chr8	52645728	Nonsense_Mutation	NA	R1321*	0.23
UCEC	chr8	52656194	Nonsense_Mutation	novel	*N1211_L1212insHSIKPAVKHLSSTEKYEAIIQN**	0.07
UCEC	chr8	52623736	3'UTR	novel		0.13
UCEC	chr8	52661186	Missense_Mutation	NA	I485S	0.16
UCEC	chr8	52642712	Missense_Mutation	rs765476878	R1363Q	0.48
UCEC	chr8	52656249	Missense_Mutation	NA	K1194Q	0.39
UCEC	chr8	52642371	Silent	novel	E1439E	0.16
UCEC	chr8	52656756	Missense_Mutation	NA	I1025L	0.33
UCEC	chr8	52661719	Nonsense_Mutation	NA	G392*	0.28
UCEC	chr8	52683640	Missense_Mutation	rs757154137	S93L	0.2
UCEC	chr8	52657006	Missense_Mutation	novel	M941I	0.2
UCEC	chr8	52674244	Silent	novel	K201K	0.22
UCEC	chr8	52683558	Silent	rs140310406	Q120Q	0.19
UCEC	chr8	52656774	Missense_Mutation	NA	K1019Q	0.63
UCEC	chr8	52661235	Missense_Mutation	NA	L469V	0.55
UCEC	chr8	52676449	Silent	NA	Y164Y	0.46
UCEC	chr8	52623240	3'UTR	novel		0.38
UCEC	chr8	52642510	Missense_Mutation	rs779306294	R1393H	0.54
UCEC	chr8	52683689	Nonsense_Mutation	NA	E77*	0.32
UCEC	chr8	52656600	Missense_Mutation	NA	L1077V	0.58
UCEC	chr8	52661649	Missense_Mutation	novel	S415N	0.19
UCEC	chr8	52676369	Missense_Mutation	novel	H191P	0.13
UCEC	chr8	52685434	Silent	novel	T12T	0.4
UCEC	chr8	52657509	Missense_Mutation	novel	S774G	0.13
UCEC	chr8	52661194	Silent	novel	R482R	0.25
UCEC	chr8	52657034	Missense_Mutation	novel	Q932R	0.15
UCEC	chr8	52623647	3'UTR	novel		0.4
UCEC	chr8	52660637	Missense_Mutation	rs770511277	R550C	0.35
UCEC	chr8	52673948	Missense_Mutation	novel	D300G	0.27
UCEC	chr8	52623353	3'UTR	novel		0.15
UCEC	chr8	52657522	Silent	novel	I769I	0.45
UCEC	chr8	52656390	Nonsense_Mutation	novel	E1147*	0.54
UCEC	chr8	52657064	Missense_Mutation	novel	A922D	0.44
UCEC	chr8	52657592	Missense_Mutation	rs756595819	S746L	0.4
UCEC	chr8	52683631	Missense_Mutation	NA	N96S	0.04
UCEC	chr8	52656415	Silent	rs768303261	S1138S	0.69
UCEC	chr8	52656857	Nonsense_Mutation	novel	L991*	0.34
UCEC	chr8	52645842	Missense_Mutation	novel	D1283Y	0.2
UCEC	chr8	52657364	Missense_Mutation	NA	F822C	0.33
UCEC	chr8	52673850	Missense_Mutation	novel	S333R	0.46
UCEC	chr8	52623750	3'UTR	novel		0.46
UCEC	chr8	52645728	Nonsense_Mutation	NA	R1321*	0.24
UCEC	chr8	52656737	Missense_Mutation	novel	S1031Y	0.39
UCEC	chr8	52656006	Splice_Site	NA	X1274_splice	0.27
UCEC	chr8	52656379	Missense_Mutation	novel	I1150M	0.36
UCEC	chr8	52656511	Silent	novel	K1106K	0.32
UCEC	chr8	52657858	Silent	novel	E657E	0.22
UCEC	chr8	52674208	Silent	novel	Y213Y	0.28
UCEC	chr8	52683578	Missense_Mutation	novel	T114A	0.18
UCEC	chr8	52628106	Frame_Shift_Ins	novel	*F1521Sfs53**	0.12
UCEC	chr8	52645728	Nonsense_Mutation	NA	R1321*	0.22
UCEC	chr8	52683640	Missense_Mutation	rs757154137	S93L	0.26
UCEC	chr8	52645829	Missense_Mutation	novel	L1287S	0.44
UCEC	chr8	52657580	Missense_Mutation	novel	P750H	0.48
UCEC	chr8	52657093	Frame_Shift_Ins	novel	*E912Dfs16**	0.13
UCEC	chr8	52656077	Missense_Mutation	rs762519571	L1251S	0.19
UCEC	chr8	52623758	3'UTR	rs541871826		0.26
UCEC	chr8	52642492	Missense_Mutation	novel	P1399H	0.32
UCEC	chr8	52656661	Silent	rs369925562	T1056T	0.3
UCEC	chr8	52636063	Silent	NA	N1448N	0.22
UCEC	chr8	52656051	Missense_Mutation	novel	L1260V	0.08
UCEC	chr8	52674165	Missense_Mutation	novel	D228Y	0.41
UCEC	chr8	52683639	Silent	rs374755456	S93S	0.4
UCEC	chr8	52674213	Frame_Shift_Del	novel	*H211Qfs14**	0.35
UCEC	chr8	52674093	Nonsense_Mutation	NA	E252*	0.28
UCEC	chr8	52656225	Missense_Mutation	novel	E1202K	0.42
UCEC	chr8	52683548	Splice_Site	novel	X123_splice	0.2
UCEC	chr8	52656938	Frame_Shift_Del	NA	*K964Sfs13**	0.5
UCEC	chr8	52623100	3'UTR	novel		0.28
UCEC	chr8	52657146	Silent	novel	L895L	0.11
UCEC	chr8	52668178	Missense_Mutation	novel	I339S	0.3
UCEC	chr8	52622698	3'UTR	novel		0.23
UCEC	chr8	52636058	Missense_Mutation	rs775020996	H1450R	0.19
UCEC	chr8	52673949	Missense_Mutation	novel	D300N	0.08
UCEC	chr8	52656437	Frame_Shift_Ins	novel	*I1131Rfs13**	0.13
UCEC	chr8	52657803	Missense_Mutation	novel	V676L	0.07
UCEC	chr8	52657805	Frame_Shift_Ins	novel	*T675Nfs18**	0.07
UCEC	chr8	52645703	Missense_Mutation	NA	Q1329R	0.07
UCEC	chr8	52656249	Frame_Shift_Ins	novel	K1194*	0.04
UCEC	chr8	52656250	Nonsense_Mutation	novel	Q1193_K1194ins*	0.04
UCEC	chr8	52657093	Nonsense_Mutation	novel	*E912_F913insILVFDL**	0.08
UCEC	chr8	52642406	Frame_Shift_Del	novel	*T1428Qfs15**	0.12
UCEC	chr8	52657040	Frame_Shift_Del	novel	*K930Rfs6**	0.22
UCEC	chr8	52657389	Missense_Mutation	novel	T814P	0.36
UCEC	chr8	52683670	Missense_Mutation	NA	R83H	0.26
UCEC	chr8	52622503	3'UTR	novel		0.6
UCEC	chr8	52657173	Missense_Mutation	NA	E886K	0.47
UCEC	chr8	52623746	3'UTR	novel		0.34
UCEC	chr8	52656111	Nonsense_Mutation	novel	E1240*	0.13
UCEC	chr8	52645728	Nonsense_Mutation	NA	R1321*	0.42
UCEC	chr8	52624776	Frame_Shift_Ins	novel	*S1550Rfs6**	0.09
UCEC	chr8	52636062	Missense_Mutation	rs767180126	I1449V	0.15
UCEC	chr8	52645867	Missense_Mutation	novel	S1274R	0.35
UCEC	chr8	52623353	3'UTR	novel		0.5
UCEC	chr8	52645728	Nonsense_Mutation	NA	R1321*	0.5
UCEC	chr8	52683634	Frame_Shift_Del	novel	*E95Kfs2**	0.32
UCEC	chr8	52674009	Missense_Mutation	novel	E280K	0.34
UCEC	chr8	52624738	Silent	novel	K1562K	0.41
UCEC	chr8	52676495	Missense_Mutation	NA	G149D	0.25
UCEC	chr8	52623744	3'UTR	novel		0.28
UCEC	chr8	52622554	3'UTR	novel		0.63
UCEC	chr8	52622665	3'UTR	novel		0.42
UCEC	chr8	52673969	Missense_Mutation	rs202008366	T293M	0.3
UCEC	chr8	52683670	Missense_Mutation	NA	R83H	0.31
UCEC	chr8	52623143	3'UTR	novel		0.38
UCEC	chr8	52656214	Silent	rs771579613	Y1205Y	0.38
UCEC	chr8	52657083	Missense_Mutation	novel	V916I	0.4
UCS	chr8	52673940	Missense_Mutation	rs772801563	F303L	0.71

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.0364	0.20625
UCS	AMP	0.5893	4.2724e-06

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.017	Kaplan-Meier Survival Analysis
STAD	0.039	Kaplan-Meier Survival Analysis
SARC	0.041	Kaplan-Meier Survival Analysis
MESO	0.035	Kaplan-Meier Survival Analysis
ACC	0.027	Kaplan-Meier Survival Analysis
HNSC	0.027	Kaplan-Meier Survival Analysis
SKCM	0.0002	Kaplan-Meier Survival Analysis
BRCA	0.015	Kaplan-Meier Survival Analysis
KIRP	0.00014	Kaplan-Meier Survival Analysis
PAAD	0.01	Kaplan-Meier Survival Analysis
LAML	0.0069	Kaplan-Meier Survival Analysis
KICH	0.0027	Kaplan-Meier Survival Analysis
UCEC	0.0011	Kaplan-Meier Survival Analysis
LGG	0.011	Kaplan-Meier Survival Analysis
LUAD	0.04	Kaplan-Meier Survival Analysis
UVM	0.045	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000023287 (Gene tree)
Gene ID: 9821
Gene Symbol: RB1CC1
Alias: KIAA0203|Cc1|DRAGOU14|FIP200|ATG17|PPP1R131
Full Name: RB1 inducible coiled-coil 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 123,388 bases
Position: chr8:52,622,456-52,745,843
Accession: 15574
RBP type: non-canonical RBP
Summary: The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29130360	Autophagy and innate immunity: Insights from invertebrate model organisms.	Autophagy	2018	Kuo CJ	doi: 10.1080/15548627.2017.1389824

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000025008	RB1CC1-201	6635	XM_011517643	ENSP00000025008	1594 (aa)	XP_011515945	Q8TDY2
ENST00000522957	RB1CC1-209	1297	-	-	- (aa)	-	-
ENST00000518710	RB1CC1-206	711	-	ENSP00000429879	52 (aa)	-	E5RH63
ENST00000521611	RB1CC1-208	528	-	-	- (aa)	-	-
ENST00000518468	RB1CC1-205	507	-	ENSP00000429611	15 (aa)	-	E5RHX0
ENST00000517963	RB1CC1-203	551	-	ENSP00000429918	72 (aa)	-	E5RH44
ENST00000518211	RB1CC1-204	891	-	ENSP00000429115	42 (aa)	-	E5RJC1
ENST00000523594	RB1CC1-210	560	-	ENSP00000430792	109 (aa)	-	H0YC28
ENST00000519912	RB1CC1-207	470	-	ENSP00000430809	127 (aa)	-	H0YC30
ENST00000435644	RB1CC1-202	6614	XM_011517645	ENSP00000396067	1591 (aa)	XP_011515947	Q8TDY2

Gene Model

Click here to download ENSG00000023287's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04140	Autophagy - animal	KEGG
hsa04211	Longevity regulating pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000023287	Body Weights and Measures	4.405e-005	17658951
ENSG00000023287	Testosterone	2.6590000E-005	-
ENSG00000023287	Menarche	1E-8	25231870
ENSG00000023287	Leptin	3E-7	23251661
ENSG00000023287	Blood Pressure	7E-6	26969751

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000023287's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000045	autophagosome assembly	21873635.	IBA	Process
GO:0000407	phagophore assembly site	28561066.	IDA	Component
GO:0000422	autophagy of mitochondrion	21873635.	IBA	Process
GO:0001889	liver development	-	IEA	Process
GO:0001934	positive regulation of protein phosphorylation	21873635.	IBA	Process
GO:0005515	protein binding	19211835.19597335.20562859.21903422.23262492.23392225.23524951.25686248.27334615.28561066.29950492.	IPI	Function
GO:0005764	lysosome	28561066.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006914	autophagy	-	ISS	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0007507	heart development	-	IEA	Process
GO:0016236	macroautophagy	-	TAS	Process
GO:0016241	regulation of macroautophagy	-	TAS	Process
GO:0019898	extrinsic component of membrane	21873635.	IBA	Component
GO:0019901	protein kinase binding	21873635.	IBA	Function
GO:0030242	autophagy of peroxisome	21873635.	IBA	Process
GO:0031965	nuclear membrane	-	IDA	Component
GO:0034045	phagophore assembly site membrane	21873635.	IBA	Component
GO:0034045	phagophore assembly site membrane	-	ISS	Component
GO:0034727	piecemeal microautophagy of the nucleus	21873635.	IBA	Process
GO:0045793	positive regulation of cell size	-	IEA	Process
GO:0046330	positive regulation of JNK cascade	-	IEA	Process
GO:0060090	molecular adaptor activity	21873635.	IBA	Function
GO:0061709	reticulophagy	21873635.	IBA	Process
GO:0061723	glycophagy	21873635.	IBA	Process
GO:1990316	Atg1/ULK1 kinase complex	21873635.	IBA	Component
GO:1990316	Atg1/ULK1 kinase complex	19211835.	IPI	Component
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.