EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25789740Knockdown of glutamate cysteine ligase catalytic subunit by siRNA causes the gold nanoparticles-induced cytotoxicity in lung cancer cells.PLoS One2015 Mar 19Liu Mdoi: 10.1371/journal.pone.0118870
14532974The modifier subunit of glutamate cysteine ligase (GCLM) is a molecular target for amelioration of cisplatin resistance in lung cancer.Int J Oncol2003 NovInoue Y-
26894974Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia.Oncotarget2016 Mar 22Syu JPdoi: 10.18632/oncotarget.7406.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1938888883'UTRnovel0.18
BLCAchr193894701Missense_MutationNAL190F0.36
BLCAchr193904541SilentNAI58I0.19
BLCAchr193897853Missense_MutationnovelS108N0.48
BRCAchr193896695Nonsense_MutationNAQ155*0.25
BRCAchr1938885773'UTRnovel0.26
BRCAchr193897881Missense_MutationNAE99Q0.94
CESCchr193901636Missense_MutationNAH76Y0.21
COADchr193894634Missense_MutationNAL212S0.19
COADchr193896775Missense_Mutationrs773867359A128V0.48
COADchr193904582Missense_MutationnovelD45N0.24
ESCAchr193904582Missense_MutationnovelD45H0.21
ESCAchr1938887983'UTRnovel0.47
ESCAchr1938886233'UTRnovel0.54
GBMchr1938888483'UTRnovel0.18
GBMchr193889099Missense_Mutationrs761296185A239V0.3
HNSCchr193889042Missense_MutationnovelG258E0.08
KIRCchr193904544SilentNAQ57Q0.27
KIRPchr193894650Missense_MutationnovelF207L0.19
LAMLchr193896812Missense_MutationNAV116I0.39
LIHCchr193896620Missense_MutationnovelQ180E0.46
LIHCchr193889062Silentrs567112849S251S0.4
LUSCchr193901612Missense_MutationNAD84Y0.22
LUSCchr1938889373'UTRnovel0.14
LUSCchr193894669SilentNAL200L0.34
OVchr1938887833'UTRnovel0.21
OVchr193896736Missense_MutationNAE141G0.35
PAADchr193889160Splice_SitenovelX219_splice0.11
READchr193889099Missense_Mutationrs761296185A239V0.25
SKCMchr193889136Nonsense_MutationNAQ227*0.36
SKCMchr193904585Missense_MutationnovelH44Y0.32
SKCMchr193896748Missense_MutationNAN137I0.4
SKCMchr193889088Missense_Mutationrs376457310V243M0.67
SKCMchr193896766Missense_MutationnovelP131L0.53
SKCMchr193896767Missense_Mutationrs780522121P131S0.55
STADchr193894681Missense_MutationNAM196I0.3
STADchr193889025Missense_MutationNAG264C0.1
STADchr193894632Missense_MutationNAT213A0.29
UCECchr193896618Missense_MutationnovelQ180H0.54
UCECchr193889045Missense_MutationNAR257K0.36
UCECchr193901624Missense_MutationnovelK80Q0.33
UCECchr193889053SilentNAV254V0.1
UCECchr1938888153'UTRnovel0.29
UCECchr193894646Missense_Mutationrs764757939D208G0.36
UCECchr193889062Silentrs567112849S251S0.06
UCECchr193889000Missense_MutationnovelR272M0.13
UCECchr193888995Missense_MutationnovelS274P0.34
UCECchr1938886673'UTRnovel0.31
UCECchr193904567Frame_Shift_DelnovelT50Pfs*20.31
UCECchr193889098Silentrs187864335A239A0.56
UCECchr193896635Missense_MutationNAL175M0.35
UCECchr193896752Missense_MutationnovelV136I0.32

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.27225.7821e-10
CESCDEL0.08140.01281
COADDEL0.22390.00038973
DLBCDEL0.08330.0017831
MESODEL0.41385.9874e-12
PRADDEL0.10770.0061054
SKCMDEL0.21539.7877e-07
STADDEL0.17460.0040659
TGCTAMP0.17330.088103

Survival Analysis
CancerP-value Q-value
KIRC0.00051

Kaplan-Meier Survival Analysis

SARC0.0053

Kaplan-Meier Survival Analysis

UCS0.041

Kaplan-Meier Survival Analysis

KIRP0.00018

Kaplan-Meier Survival Analysis

COAD0.026

Kaplan-Meier Survival Analysis

BLCA0.013

Kaplan-Meier Survival Analysis

READ0.049

Kaplan-Meier Survival Analysis

LAML0.01

Kaplan-Meier Survival Analysis

GBM0.03

Kaplan-Meier Survival Analysis

LIHC0.00073

Kaplan-Meier Survival Analysis

CHOL0.0049

Kaplan-Meier Survival Analysis

LUAD0.035

Kaplan-Meier Survival Analysis

Drugs

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Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000023909 (Gene tree)
Gene ID
2730
Gene Symbol
GCLM
Alias
GLCLR
Full Name
glutamate-cysteine ligase modifier subunit
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
24,394 bases
Position
chr1:93,885,205-93,909,598
Accession
4312
RBP type
non-canonical RBP
Summary
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
18279677Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis.Free Radic Biol Med2008 Apr 15Pereda Jdoi: 10.1016/j.freeradbiomed.2008.01.018
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000467772GCLM-203625--- (aa)--
ENST00000615724GCLM-2043008XM_011541261ENSP00000484507252 (aa)XP_011539563P48507
ENST00000370238GCLM-2014857XM_017001056ENSP00000359258274 (aa)XP_016856545P48507
ENST00000462183GCLM-202583--- (aa)--
Gene Model
Click here to download ENSG00000023909's gene model file
Pathways
Pathway IDPathway NameSource
hsa00270Cysteine and methionine metabolismKEGG
hsa00480Glutathione metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa04216FerroptosisKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000023909's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000023909GCLM10096.350ENSMUSG00000028124Gclm10096.350Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004357glutamate-cysteine ligase activity9841880.IDAFunction
GO:0004357glutamate-cysteine ligase activity16183645.IMPFunction
GO:0005829cytosol9895302.NASComponent
GO:0005829cytosol-TASComponent
GO:0006534cysteine metabolic process-IEAProcess
GO:0006536glutamate metabolic process9841880.9895302.IDAProcess
GO:0006750glutathione biosynthetic process21873635.IBAProcess
GO:0006750glutathione biosynthetic process10395918.IDAProcess
GO:0006750glutathione biosynthetic process-IEAProcess
GO:0006750glutathione biosynthetic process12081989.IMPProcess
GO:0006750glutathione biosynthetic process-TASProcess
GO:0006979response to oxidative stress10395918.IDAProcess
GO:0007568aging-IEAProcess
GO:0007584response to nutrient-IEAProcess
GO:0008637apoptotic mitochondrial changes-IEAProcess
GO:0014823response to activity-IEAProcess
GO:0017109glutamate-cysteine ligase complex21873635.IBAComponent
GO:0017109glutamate-cysteine ligase complex9841880.IDAComponent
GO:0030234enzyme regulator activity21873635.IBAFunction
GO:0035226glutamate-cysteine ligase catalytic subunit binding9675072.9841880.IPIFunction
GO:0035229positive regulation of glutamate-cysteine ligase activity21873635.IBAProcess
GO:0035729cellular response to hepatocyte growth factor stimulus-IEAProcess
GO:0035733hepatic stellate cell activation-IEAProcess
GO:0042493response to drug9895302.IDAProcess
GO:0043524negative regulation of neuron apoptotic process-IEAProcess
GO:0044344cellular response to fibroblast growth factor stimulus-IEAProcess
GO:0044752response to human chorionic gonadotropin-IEAProcess
GO:0046982protein heterodimerization activity-IEAFunction
GO:0050880regulation of blood vessel size12975258.IMPProcess
GO:0051409response to nitrosative stress-IEAProcess
GO:0051900regulation of mitochondrial depolarization-IEAProcess
GO:0071333cellular response to glucose stimulus-IEAProcess
GO:0071372cellular response to follicle-stimulating hormone stimulus-IEAProcess
GO:0097069cellular response to thyroxine stimulus-IEAProcess
GO:1990830cellular response to leukemia inhibitory factor-IEAProcess
GO:2001237negative regulation of extrinsic apoptotic signaling pathway-IEAProcess
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