EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16820880	Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target.	Int J Oncol	2006 Aug	Shimokawa T	-
23053644	TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.	Breast Cancer Res Treat	2012 Nov	Aleskandarany MA	doi: 10.1007/s10549-012-2249-4

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr20	44951946	Missense_Mutation	NA	S146L	0.18
BLCA	chr20	44943152	Missense_Mutation	novel	P296H	0.14
BLCA	chr20	44943561	Silent	NA	V239V	0.17
BLCA	chr20	44943178	Silent	novel	L287L	0.13
BLCA	chr20	44943145	Silent	NA	Q298Q	0.17
BLCA	chr20	44948824	Missense_Mutation	novel	E202Q	0.14
BLCA	chr20	44956443	Missense_Mutation	novel	R57P	0.44
BRCA	chr20	44943456	Silent	NA	L274L	0.17
BRCA	chr20	44948768	Silent	NA	L220L	0.1
BRCA	chr20	44956465	Missense_Mutation	NA	E50K	0.15
CESC	chr20	44956410	Missense_Mutation	novel	R68K	0.38
CESC	chr20	44943456	Silent	novel	L274L	0.41
CESC	chr20	44948871	Missense_Mutation	NA	S186C	0.51
CESC	chr20	44951881	Missense_Mutation	novel	E168K	0.36
CESC	chr20	44951968	Missense_Mutation	NA	E139Q	0.45
COAD	chr20	44943142	Missense_Mutation	NA	K299N	0.39
COAD	chr20	44958517	Intron	novel		0.2
COAD	chr20	44960381	5'UTR	novel		0.35
COAD	chr20	44951961	Missense_Mutation	rs756307089	R141L	0.06
COAD	chr20	44955186	Missense_Mutation	NA	L88M	0.64
COAD	chr20	44951891	Missense_Mutation	NA	E164D	0.32
COAD	chr20	44958459	Intron	NA		0.19
ESCA	chr20	44943180	Missense_Mutation	novel	L287F	0.08
HNSC	chr20	44956386	Missense_Mutation	rs779517223	S76L	0.07
HNSC	chr20	44943573	Silent	novel	L235L	0.22
KIRC	chr20	44943568	In_Frame_Ins	novel	Y237delinsLN	0.24
KIRP	chr20	44951912	Silent	rs767367318	R157R	0.4
LAML	chr20	44943491	Missense_Mutation	novel	A263T	0.33
LAML	chr20	44951874	Missense_Mutation	novel	A170V	0.03
LUAD	chr20	44956471	Nonsense_Mutation	NA	E48*	0.1
LUAD	chr20	44955122	Missense_Mutation	novel	K109R	0.07
LUSC	chr20	44943098	3'UTR	novel		0.18
LUSC	chr20	44956407	Missense_Mutation	novel	D69G	0.07
LUSC	chr20	44955179	Missense_Mutation	novel	R90L	0.25
PAAD	chr20	44948822	Missense_Mutation	novel	E202D	0.18
READ	chr20	44955085	Silent	novel	A121A	0.06
READ	chr20	44951895	Missense_Mutation	novel	S163L	0.45
SKCM	chr20	44951918	Silent	novel	Q155Q	0.39
SKCM	chr20	44956456	Missense_Mutation	NA	L53F	0.23
SKCM	chr20	44943118	Silent	NA	N307N	0.4
STAD	chr20	44943510	Silent	NA	L256L	0.12
STAD	chr20	44955072	Missense_Mutation	NA	N126D	0.12
STAD	chr20	44951838	Missense_Mutation	NA	N182S	0.14
UCEC	chr20	44960216	Nonsense_Mutation	novel	Q40*	0.86
UCEC	chr20	44943137	Missense_Mutation	rs758049930	R301Q	0.16
UCEC	chr20	44943102	3'UTR	novel		0.24
UCEC	chr20	44943092	3'UTR	novel		0.19
UCEC	chr20	44948783	Silent	novel	K215K	0.08
UCEC	chr20	44951992	Missense_Mutation	novel	A131S	0.25
UCEC	chr20	44956393	Missense_Mutation	novel	C74R	0.18
UCEC	chr20	44942877	3'UTR	novel		0.38
UCEC	chr20	44955183	Silent	novel	L89L	0.39
UCEC	chr20	44943145	Missense_Mutation	novel	Q298H	0.13
UCEC	chr20	44942612	3'UTR	novel		0.25
UCEC	chr20	44958376	Intron	novel		0.27
UCEC	chr20	44956386	Missense_Mutation	rs779517223	S76L	0.28
UCEC	chr20	44951894	Silent	rs759565599	S163S	0.36
UCEC	chr20	44942538	3'UTR	novel		0.32
UCEC	chr20	44943534	Missense_Mutation	novel	K248N	0.43
UCEC	chr20	44960268	Silent	novel	N22N	0.33
UCEC	chr20	44942994	3'UTR	novel		0.25
UCEC	chr20	44960312	Missense_Mutation	NA	S8A	0.3
UCEC	chr20	44948733	Missense_Mutation	novel	N232S	0.23
UCEC	chr20	44942982	3'UTR	novel		0.24
UCEC	chr20	44960292	Silent	novel	A14A	0.24
UCEC	chr20	44955074	Missense_Mutation	novel	I125N	0.49
UCEC	chr20	44943136	Silent	novel	R301R	0.27
UCEC	chr20	44951981	Missense_Mutation	novel	D134E	0.19
UCEC	chr20	44951891	Missense_Mutation	NA	E164D	0.41
UCEC	chr20	44956408	Missense_Mutation	novel	D69Y	0.04

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LAML	DEL	0.0209	0.14746
LUAD	DEL	0.1221	0.18308
PRAD	AMP	0.0488	0.07085

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0036	Kaplan-Meier Survival Analysis
SARC	0.0001	Kaplan-Meier Survival Analysis
MESO	0.0003	Kaplan-Meier Survival Analysis
HNSC	0.00011	Kaplan-Meier Survival Analysis
ESCA	0.015	Kaplan-Meier Survival Analysis
COAD	0.047	Kaplan-Meier Survival Analysis
BLCA	0.035	Kaplan-Meier Survival Analysis
READ	0.034	Kaplan-Meier Survival Analysis
LAML	0.0064	Kaplan-Meier Survival Analysis
UCEC	0.0059	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.00019	Kaplan-Meier Survival Analysis
THCA	0.0015	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000025772 (Gene tree)
Gene ID: 10953
Gene Symbol: TOMM34
Alias: TOM34|HTOM34P
Full Name: translocase of outer mitochondrial membrane 34
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 18,357 bases
Position: chr20:44,942,130-44,960,486
Accession: 15746
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
7941739	Organization of the centromeric region of chromosome XIV in Saccharomyces cerevisiae.	Yeast	1994 Apr	Lalo D	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000372813	TOMM34-201	2062	XM_005260254	ENSP00000361900	309 (aa)	XP_005260311	Q15785

Gene Model

Click here to download ENSG00000025772's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000025772	Macular Degeneration	1.268967E-5	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000025772's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	21044950.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005741	mitochondrial outer membrane	9324309.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006626	protein targeting to mitochondrion	9324309.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	9324309.	TAS	Component
GO:0031072	heat shock protein binding	9660753.	IPI	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.