EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18353764	Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis.	Mol Cell Proteomics	2008 Jul	Thorsen K	doi: 10.1074/mcp.M700590-MCP200
25449281	Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway.	Biochem Biophys Res Commun	2014 Dec 12	Yoshimoto T	doi: 10.1016/j.bbrc.2014.10.154
22940724	Proteomic differential display identifies upregulated vinculin as a possible biomarker of pancreatic cancer.	Oncol Rep	2012 Nov	Wang Y	doi: 10.3892/or.2012.2004
25997717	Integrin β4 and vinculin contained in exosomes are potential markers for progression of prostate cancer associated with taxane-resistance.	Int J Oncol	2015 Jul	Kawakami K	doi: 10.3892/ijo.2015.3011
28266545	Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin.	Nat Commun	2017 Mar 7	Gao Y	doi: 10.1038/ncomms14483.
21171262	[Vinculin and the androgen receptor in prostate cancer: expressions and correlations].	Zhonghua Nan Ke Xue	2010 Sep	Zhu LY	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr10	74097257	Silent	novel	F599F	0.35
BLCA	chr10	74089331	Missense_Mutation	novel	K386N	0.06
BLCA	chr10	74089347	Nonsense_Mutation	NA	Q392*	0.83
BLCA	chr10	74103857	Missense_Mutation	novel	G687V	0.09
BLCA	chr10	74114202	Missense_Mutation	novel	A990S	0.79
BRCA	chr10	74072850	Nonsense_Mutation	NA	S207*	0.29
BRCA	chr10	74101091	Silent	NA	T672T	0.57
BRCA	chr10	74105258	Missense_Mutation	NA	R780H	0.2
BRCA	chr10	74074812	Missense_Mutation	NA	N231S	0.34
BRCA	chr10	74083444	Missense_Mutation	NA	R318L	0.33
BRCA	chr10	74075413	Intron	novel		0.41
BRCA	chr10	74118180	3'UTR	novel		0.27
BRCA	chr10	74094296	Nonsense_Mutation	NA	R460*	0.57
BRCA	chr10	74109126	Silent	rs778360845	L905L	0.43
BRCA	chr10	74118180	3'UTR	novel		0.14
BRCA	chr10	74103859	Missense_Mutation	NA	N688D	0.33
CESC	chr10	74089245	Missense_Mutation	novel	Q358E	0.09
CESC	chr10	74074766	Frame_Shift_Del	NA	*N217Tfs7**	0.24
CESC	chr10	73998147	5'UTR	novel		0.38
CESC	chr10	74075633	Intron	novel		0.34
CESC	chr10	73998147	5'UTR	novel		0.42
CESC	chr10	74074857	Missense_Mutation	rs746577068	R246H	0.46
CESC	chr10	74077373	Intron	novel		0.34
CESC	chr10	74074751	Frame_Shift_Ins	novel	*V213Cfs4**	0.47
CESC	chr10	74105204	Missense_Mutation	rs540039788	R762Q	0.31
CESC	chr10	74114212	Missense_Mutation	NA	R993H	0.17
CESC	chr10	74114805	Missense_Mutation	novel	R1055Q	0.12
CESC	chr10	73998183	5'UTR	novel		0.64
CESC	chr10	74077382	Intron	novel		0.4
COAD	chr10	74071084	Splice_Site	novel	X167_splice	0.07
COAD	chr10	74083506	Missense_Mutation	rs759961842	R339C	0.12
COAD	chr10	74103835	Missense_Mutation	rs759356162	R680C	0.44
COAD	chr10	74074796	Missense_Mutation	rs146910007	A226T	0.26
COAD	chr10	74112069	Missense_Mutation	rs534101808	A969V	0.31
COAD	chr10	73998298	Nonsense_Mutation	novel	E31*	0.16
COAD	chr10	74112015	Missense_Mutation	rs368570586	P951R	0.48
COAD	chr10	74112004	Silent	rs566296495	D947D	0.24
COAD	chr10	74105347	Missense_Mutation	rs751458490	D810N	0.11
COAD	chr10	74111981	Missense_Mutation	novel	P940T	0.05
COAD	chr10	74090028	Nonsense_Mutation	NA	W394*	0.19
COAD	chr10	74070978	Missense_Mutation	NA	R132C	0.18
COAD	chr10	74074809	Missense_Mutation	rs749628307	R230H	0.15
COAD	chr10	74109155	Missense_Mutation	NA	K915R	0.11
COAD	chr10	74118182	3'UTR	novel		0.38
ESCA	chr10	73998251	Missense_Mutation	novel	P15L	0.27
ESCA	chr10	74114212	Missense_Mutation	NA	R993H	0.2
ESCA	chr10	74103838	Missense_Mutation	novel	I681V	0.41
ESCA	chr10	74043116	Nonsense_Mutation	novel	Q68*	0.41
ESCA	chr10	74075362	Intron	novel		0.3
ESCA	chr10	74107268	Silent	novel	L825L	0.28
ESCA	chr10	74118143	Missense_Mutation	novel	V1127F	0.36
GBM	chr10	74070761	Missense_Mutation	novel	G111R	0.05
GBM	chr10	74083448	Silent	novel	R319R	0.26
GBM	chr10	74107292	Nonsense_Mutation	novel	E833*	0.19
GBM	chr10	74109089	Missense_Mutation	novel	V893G	0.18
GBM	chr10	74072749	Missense_Mutation	novel	K173N	0.1
HNSC	chr10	74090160	Silent	novel	I438I	0.17
HNSC	chr10	74097207	Missense_Mutation	novel	L583I	0.14
HNSC	chr10	74097309	Missense_Mutation	NA	P617S	0.17
HNSC	chr10	73998169	5'UTR	novel		0.17
KIRC	chr10	74101080	Missense_Mutation	NA	R669G	0.25
KIRC	chr10	74071001	Frame_Shift_Del	novel	*K139Nfs28**	0.16
KIRP	chr10	74118055	Missense_Mutation	novel	N1097K	0.49
LAML	chr10	74043148	Silent	novel	F78F	0.04
LGG	chr10	74074755	Missense_Mutation	NA	F212C	0.06
LIHC	chr10	74094384	Missense_Mutation	NA	A489V	0.05
LIHC	chr10	74071034	Frame_Shift_Del	novel	*V151Wfs18**	0.59
LIHC	chr10	74111930	Missense_Mutation	NA	V923M	0.26
LIHC	chr10	74118320	3'UTR	novel		0.47
LIHC	chr10	74082513	Missense_Mutation	novel	K281N	0.11
LIHC	chr10	73998156	5'UTR	novel		0.5
LUAD	chr10	74089347	Nonsense_Mutation	NA	Q392*	0.22
LUAD	chr10	74095751	Silent	novel	R547R	0.09
LUAD	chr10	74100948	Missense_Mutation	novel	V625I	0.24
LUAD	chr10	74105350	Missense_Mutation	novel	P811S	0.18
LUAD	chr10	74082496	Missense_Mutation	NA	K276E	0.07
LUAD	chr10	74083365	Splice_Site	novel	X292_splice	0.18
LUAD	chr10	74114326	Missense_Mutation	NA	R1031L	0.17
LUAD	chr10	74101078	Missense_Mutation	novel	A668V	0.19
LUSC	chr10	74095790	Missense_Mutation	NA	A560S	0.29
LUSC	chr10	74043087	Missense_Mutation	novel	G58E	0.3
LUSC	chr10	74089226	Missense_Mutation	novel	Q351H	0.17
LUSC	chr10	74094398	Missense_Mutation	NA	E494Q	0.3
LUSC	chr10	74105240	Frame_Shift_Del	NA	*S774Wfs9**	0.22
LUSC	chr10	74114212	Missense_Mutation	NA	R993H	0.49
LUSC	chr10	74109011	Missense_Mutation	novel	E867G	0.17
MESO	chr10	74105236	Frame_Shift_Del	novel	*N773Sfs4**	0.27
OV	chr10	74103902	Missense_Mutation	novel	W702S	0.06
OV	chr10	74097329	Missense_Mutation	NA	E623D	0.18
OV	chr10	74111997	Missense_Mutation	novel	M945R	0.09
OV	chr10	74107335	Missense_Mutation	NA	P847R	0.34
OV	chr10	74107288	Frame_Shift_Del	novel	*R832Efs23**	0.05
OV	chr10	74103862	Missense_Mutation	NA	Q689E	0.42
OV	chr10	74090093	Missense_Mutation	rs758811315	R416Q	0.2
OV	chr10	74114871	Missense_Mutation	NA	T1077N	0.2
OV	chr10	74083472	Missense_Mutation	novel	M327I	0.15
PAAD	chr10	74103836	Missense_Mutation	novel	R680H	0.18
PAAD	chr10	74118213	3'UTR	novel		0.21
PAAD	chr10	74094344	Missense_Mutation	novel	K476E	0.07
PRAD	chr10	74083404	Nonsense_Mutation	novel	E305*	0.39
READ	chr10	74118114	Missense_Mutation	novel	R1117Q	0.38
SKCM	chr10	74070985	Frame_Shift_Del	novel	*I135Lfs34**	0.09
SKCM	chr10	74105303	Missense_Mutation	NA	S795F	0.4
SKCM	chr10	74072786	Missense_Mutation	novel	E186K	0.25
SKCM	chr10	74109048	Silent	novel	E879E	0.27
SKCM	chr10	74107309	In_Frame_Del	novel	Q838_P840delinsH	0.51
SKCM	chr10	74074808	Missense_Mutation	rs139312390	R230C	0.34
SKCM	chr10	74094285	Missense_Mutation	NA	S456F	0.54
SKCM	chr10	74095669	Silent	novel	I519I	0.98
SKCM	chr10	74095670	Missense_Mutation	rs377722209	R520W	0.98
SKCM	chr10	74070978	Missense_Mutation	NA	R132C	0.39
SKCM	chr10	74094437	Missense_Mutation	NA	P507S	0.61
SKCM	chr10	74094375	Missense_Mutation	novel	P486L	0.41
SKCM	chr10	74097325	Missense_Mutation	rs771590749	R622K	0.2
SKCM	chr10	74107335	Missense_Mutation	NA	P847L	0.35
SKCM	chr10	74089340	Silent	rs377730275	D389D	0.37
STAD	chr10	74111910	Missense_Mutation	rs143321584	P916L	0.22
STAD	chr10	74094354	Missense_Mutation	novel	R479Q	0.22
STAD	chr10	74090092	Missense_Mutation	rs746004026	R416W	0.31
STAD	chr10	74105241	Silent	rs202184524	S774S	0.4
STAD	chr10	74105238	Silent	novel	N773N	0.08
STAD	chr10	74074882	Silent	NA	D254D	0.14
STAD	chr10	74108985	Silent	NA	L858L	0.1
STAD	chr10	74118067	Silent	NA	S1101S	0.35
STAD	chr10	74118242	3'UTR	novel		0.36
STAD	chr10	74072792	Nonsense_Mutation	rs397517244	R188*	0.26
STAD	chr10	74089209	Missense_Mutation	NA	S346P	0.18
STAD	chr10	74118247	3'UTR	novel		0.33
STAD	chr10	74112070	Silent	novel	A969A	0.11
STAD	chr10	74105110	Frame_Shift_Del	novel	*D733Tfs7**	0.21
STAD	chr10	74103930	Splice_Site	NA	X711_splice	0.11
STAD	chr10	74109015	Silent	NA	G868G	0.25
STAD	chr10	74082539	Frame_Shift_Del	novel	*P291Qfs13**	0.19
STAD	chr10	74095685	Missense_Mutation	NA	E525K	0.43
THCA	chr10	74075000	Intron	novel		0.13
THCA	chr10	74114365	Missense_Mutation	novel	R1044L	0.3
THCA	chr10	74109056	Frame_Shift_Ins	novel	*E883Hfs14**	0.05
UCEC	chr10	74112079	Silent	novel	S972S	0.11
UCEC	chr10	74089246	Missense_Mutation	NA	Q358R	0.33
UCEC	chr10	74107260	Missense_Mutation	NA	Y822C	0.35
UCEC	chr10	74075535	Intron	novel		0.18
UCEC	chr10	74076233	Intron	novel		0.46
UCEC	chr10	74089338	Missense_Mutation	rs776129187	D389N	0.38
UCEC	chr10	74090053	Missense_Mutation	NA	E403K	0.45
UCEC	chr10	74075616	Intron	novel		0.29
UCEC	chr10	74077527	Intron	novel		0.4
UCEC	chr10	74077650	Intron	novel		0.27
UCEC	chr10	74105161	Missense_Mutation	novel	M748V	0.27
UCEC	chr10	74114387	Missense_Mutation	novel	Q1051H	0.56
UCEC	chr10	74118220	3'UTR	novel		0.21
UCEC	chr10	74105110	Frame_Shift_Del	novel	*D733Tfs7**	0.32
UCEC	chr10	73998349	Missense_Mutation	novel	Q48E	0.41
UCEC	chr10	74112069	Missense_Mutation	rs534101808	A969V	0.17
UCEC	chr10	74095752	Missense_Mutation	rs748044427	R547Q	0.42
UCEC	chr10	74118878	3'UTR	novel		0.27
UCEC	chr10	74083408	Missense_Mutation	novel	A306V	0.35
UCEC	chr10	74090144	Missense_Mutation	rs754046223	R433H	0.26
UCEC	chr10	74095854	Missense_Mutation	novel	K581T	0.43
UCEC	chr10	74119854	3'UTR	novel		0.44
UCEC	chr10	74077150	Intron	novel		0.24
UCEC	chr10	74083459	Missense_Mutation	novel	G323V	0.05
UCEC	chr10	74094400	Missense_Mutation	NA	E494D	0.11
UCEC	chr10	74083487	Silent	NA	T332T	0.33
UCEC	chr10	74118022	Splice_Site	novel	X1087_splice	0.38
UCEC	chr10	74107292	Missense_Mutation	novel	E833K	0.09
UCEC	chr10	74111929	Missense_Mutation	novel	E922D	0.21
UCEC	chr10	74076855	Intron	novel		0.51
UCEC	chr10	74105050	Splice_Site	NA	X711_splice	0.54
UCEC	chr10	74114212	Missense_Mutation	NA	R993H	0.38
UCEC	chr10	74070809	Missense_Mutation	novel	D127N	0.38
UCEC	chr10	74074823	Nonsense_Mutation	novel	E235*	0.39
UCEC	chr10	74077463	Intron	novel		0.48
UCEC	chr10	74082469	Missense_Mutation	novel	K267E	0.11
UCEC	chr10	74090192	Missense_Mutation	novel	R449Q	0.25
UCEC	chr10	74105101	Nonsense_Mutation	novel	E728*	0.13
UCEC	chr10	74095671	Missense_Mutation	rs757009736	R520Q	0.16
UCEC	chr10	74095774	Silent	novel	Q554Q	0.36
UCEC	chr10	74112005	Missense_Mutation	novel	D948N	0.64
UCEC	chr10	74112015	Missense_Mutation	novel	P951H	0.08
UCEC	chr10	74071010	Missense_Mutation	novel	L142F	0.23
UCEC	chr10	74077288	Intron	novel		0.36
UCEC	chr10	74118114	Missense_Mutation	novel	R1117Q	0.32
UCEC	chr10	74074795	Missense_Mutation	novel	E225D	0.51
UCEC	chr10	74107240	Silent	novel	K815K	0.3
UCEC	chr10	74107327	Silent	NA	P844P	0.36
UCEC	chr10	74119758	3'UTR	novel		0.45
UCEC	chr10	74107328	Missense_Mutation	novel	P845S	0.91
UCEC	chr10	74075144	Intron	novel		0.14
UCEC	chr10	74101010	Silent	novel	E645E	0.51
UCEC	chr10	74108977	Missense_Mutation	novel	D856Y	0.5
UCEC	chr10	74109140	Missense_Mutation	NA	R910H	0.35
UCEC	chr10	74119876	3'UTR	novel		0.19
UCEC	chr10	74119146	3'UTR	novel		0.58
UCEC	chr10	74119245	3'UTR	novel		0.5
UCEC	chr10	74107327	Silent	NA	P844P	0.43
UCEC	chr10	74074972	Intron	novel		0.15
UCEC	chr10	74076835	Intron	novel		0.56
UCEC	chr10	74074922	Intron	novel		0.3
UCEC	chr10	74077126	Intron	novel		0.45
UCEC	chr10	74074781	Nonsense_Mutation	novel	Q221*	0.25
UCEC	chr10	74109023	Missense_Mutation	novel	P871H	0.43
UCEC	chr10	74114278	Missense_Mutation	novel	L1015P	0.24
UCEC	chr10	74075018	Intron	novel		0.13
UCEC	chr10	74075983	Intron	novel		0.2
UCEC	chr10	74109083	Missense_Mutation	novel	G891E	0.11
UCEC	chr10	74105204	Missense_Mutation	rs540039788	R762Q	0.21
UCEC	chr10	74076232	Intron	novel		0.17
UCEC	chr10	74072732	Missense_Mutation	novel	M168L	0.32
UCEC	chr10	74074856	Missense_Mutation	rs794729194	R246C	0.45
UCEC	chr10	74076311	Intron	novel		0.33
UCEC	chr10	74090073	Silent	novel	R409R	0.39
UCEC	chr10	74108977	Missense_Mutation	novel	D856Y	0.41
UCEC	chr10	74112005	Missense_Mutation	novel	D948N	0.35
UCEC	chr10	74077452	Intron	novel		0.28
UCEC	chr10	74112014	Missense_Mutation	rs774356864	P951S	0.42
UCEC	chr10	74043131	Missense_Mutation	novel	D73N	0.3
UCEC	chr10	74076565	Intron	novel		0.35
UCEC	chr10	74077654	Intron	novel		0.3
UCEC	chr10	74105113	Missense_Mutation	novel	K732Q	0.17
UCEC	chr10	74114212	Missense_Mutation	NA	R993H	0.22
UCEC	chr10	74074770	Missense_Mutation	NA	N217S	0.27
UCEC	chr10	74114279	Silent	NA	L1015L	0.26
UCEC	chr10	74105343	Silent	novel	I808I	0.61
UCEC	chr10	73998163	5'UTR	novel		0.42
UCEC	chr10	74082476	Missense_Mutation	novel	A269V	0.3
UCEC	chr10	74094270	Splice_Site	NA	X452_splice	0.24
UCEC	chr10	74118203	3'UTR	novel		0.4
UCEC	chr10	74114867	Missense_Mutation	rs397517241	R1076W	0.22
UCEC	chr10	74109082	Missense_Mutation	NA	G891R	0.35
UCEC	chr10	74083416	Missense_Mutation	novel	V309I	0.29
UCEC	chr10	74105119	Missense_Mutation	NA	L734M	0.1
UCEC	chr10	74118200	3'UTR	novel		0.14
UCEC	chr10	74071050	Missense_Mutation	novel	D156Y	0.18
UCEC	chr10	74097228	Missense_Mutation	novel	A590T	0.18
UCEC	chr10	74109146	Nonsense_Mutation	novel	W912*	0.25
UCEC	chr10	74111945	Missense_Mutation	novel	V928I	0.19
UCEC	chr10	74118171	3'UTR	novel		0.38
UCEC	chr10	73998147	5'UTR	novel		0.28
UCEC	chr10	74109081	Silent	rs748291846	A890A	0.38
UCEC	chr10	74074809	Missense_Mutation	rs749628307	R230H	0.44
UCEC	chr10	74075969	Intron	novel		0.4
UCEC	chr10	74082490	Missense_Mutation	novel	D274N	0.34
UCEC	chr10	74094313	Silent	novel	Q465Q	0.3
UCEC	chr10	74112098	Missense_Mutation	novel	K979E	0.46
UCS	chr10	74070691	Silent	novel	K87K	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
READ	AMP	0.0545	0.13718
THCA	DEL	0.022	0.011063

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0071	Kaplan-Meier Survival Analysis
KIRC	0.015	Kaplan-Meier Survival Analysis
STAD	0.045	Kaplan-Meier Survival Analysis
MESO	0.00015	Kaplan-Meier Survival Analysis
HNSC	0.015	Kaplan-Meier Survival Analysis
SKCM	0.032	Kaplan-Meier Survival Analysis
ESCA	0.035	Kaplan-Meier Survival Analysis
KIRP	0.0053	Kaplan-Meier Survival Analysis
PAAD	0.0011	Kaplan-Meier Survival Analysis
BLCA	0.0022	Kaplan-Meier Survival Analysis
CESC	0.027	Kaplan-Meier Survival Analysis
LAML	0.0016	Kaplan-Meier Survival Analysis
KICH	0.011	Kaplan-Meier Survival Analysis
UCEC	0.022	Kaplan-Meier Survival Analysis
DLBC	0.048	Kaplan-Meier Survival Analysis
LGG	0.00024	Kaplan-Meier Survival Analysis
LUAD	0.0048	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000035403 (Gene tree)
Gene ID: 7414
Gene Symbol: VCL
Alias: N
Full Name: vinculin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 126,171 bases
Position: chr10:73,995,193-74,121,363
Accession: 12665
RBP type: non-canonical RBP
Summary: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22709580	The metavinculin tail domain directs constitutive interactions with raver1 and vinculin RNA.	J Mol Biol	2012 Oct 5	Lee JH	doi: 10.1016/j.jmb.2012.06.015
14645243	AU-rich elements in the collagenase 3 mRNA mediate stabilization of the transcript by cortisol in osteoblasts.	J Biol Chem	2004 Feb 13	Rydziel S	-
19523901	Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions.	Structure	2009 Jun 10	Lee JH	doi: 10.1016/j.str.2009.04.010.
16339744	Estrogen regulation of the rat anterior pituitary gland proteome.	Exp Biol Med (Maywood)	2005 Dec	Blake CA	-
17591693	WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.	Mol Cell Biol	2007 Sep	Nolz JC	-
20728432	Vinculin activates inside-out signaling of integrin αIIbβ3 in Chinese hamster ovary cells.	Biochem Biophys Res Commun	2010 Sep 24	Ohmori T	doi: 10.1016/j.bbrc.2010.08.056

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000472585	VCL-204	556	-	-	- (aa)	-	-
ENST00000478896	VCL-205	727	-	-	- (aa)	-	-
ENST00000372755	VCL-202	6489	-	ENSP00000361841	1066 (aa)	-	P18206
ENST00000624354	VCL-207	3307	-	ENSP00000485551	57 (aa)	-	A0A096LPE1
ENST00000623461	VCL-206	7995	-	-	- (aa)	-	-
ENST00000461383	VCL-203	268	-	-	- (aa)	-	-
ENST00000211998	VCL-201	5490	-	ENSP00000211998	1134 (aa)	-	P18206

Gene Model

Click here to download ENSG00000035403's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04510	Focal adhesion	KEGG
hsa04520	Adherens junction	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05100	Bacterial invasion of epithelial cells	KEGG
hsa05131	Shigellosis	KEGG
hsa05146	Amoebiasis	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000035403	rs3812625	10	73997944	?	Left ventricular internal dimension in diastole	29403010	[0.039-0.081] unit decrease	0.05998	EFO_0008204
ENSG00000035403	rs10824058	10	74031881	?	Systolic blood pressure	30595370			EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000035403's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000035403	VCL	54	38.614	ENSG00000044115	CTNNA1	95	32.075	Homo_sapiens
ENSG00000035403	VCL	100	99.343	ENSMUSG00000021823	Vcl	100	99.343	Mus_musculus
ENSG00000035403	VCL	59	33.529	ENSMUSG00000037815	Ctnna1	51	33.529	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002009	morphogenesis of an epithelium	20086044.	IMP	Process
GO:0002102	podosome	-	IEA	Component
GO:0002162	dystroglycan binding	18341635.	IPI	Function
GO:0002576	platelet degranulation	-	TAS	Process
GO:0003779	actin binding	16803572.	IDA	Function
GO:0003779	actin binding	7816144.	IDA	Function
GO:0005198	structural molecule activity	-	IEA	Function
GO:0005515	protein binding	9054445.9885244.10320934.12473693.15070891.15163412.15988023.16803572.16826238.17082770.17289036.17932491.18028034.22427331.25416956.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	16130169.	TAS	Component
GO:0005911	cell-cell junction	-	ISS	Component
GO:0005912	adherens junction	-	ISS	Component
GO:0005913	cell-cell adherens junction	20086044.	IDA	Component
GO:0005916	fascia adherens	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	20086044.29162887.	IDA	Component
GO:0005925	focal adhesion	-	ISS	Component
GO:0006936	muscle contraction	-	TAS	Process
GO:0007155	cell adhesion	15501673.	TAS	Process
GO:0007160	cell-matrix adhesion	20086044.	TAS	Process
GO:0008013	beta-catenin binding	20086044.	ISS	Function
GO:0030032	lamellipodium assembly	-	ISS	Process
GO:0030055	cell-substrate junction	2116004.	NAS	Component
GO:0030336	negative regulation of cell migration	15494027.	TAS	Process
GO:0031625	ubiquitin protein ligase binding	19725078.	IPI	Function
GO:0032991	protein-containing complex	9700171.	IDA	Component
GO:0034333	adherens junction assembly	20086044.	IMP	Process
GO:0034394	protein localization to cell surface	20086044.	IMP	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0035580	specific granule lumen	-	TAS	Component
GO:0042383	sarcolemma	-	ISS	Component
GO:0043034	costamere	9415431.	IDA	Component
GO:0043034	costamere	-	ISS	Component
GO:0043297	apical junction assembly	9700171.	IMP	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045294	alpha-catenin binding	9700171.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045296	cadherin binding	20086044.	ISS	Function
GO:0048675	axon extension	-	IEA	Process
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component
GO:0070527	platelet aggregation	23382103.	HMP	Process
GO:0090136	epithelial cell-cell adhesion	20086044.	IMP	Process
GO:1903561	extracellular vesicle	24769233.	HDA	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.