EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25483184	α-catenin. A tumor suppressor beyond adherens junctions.	Cell Cycle	2014	Sun Y	doi: 10.4161/cc.29765.
18566211	alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling.	Mol Cancer Ther	2008 Jun	Inge LJ	doi: 10.1158/1535-7163.MCT-07-2029.
22469663	Identification of a Wnt-induced protein complex by affinity proteomics using an antibody that recognizes a sub-population of β-catenin.	Biochim Biophys Acta	2012 Jul	Layton MJ	doi: 10.1016/j.bbapap.2012.03.006
19656157	Tumor suppressor function of BCSC-1 in nasopharyngeal carcinoma.	Cancer Sci	2009 Oct	Zhou YQ	doi: 10.1111/j.1349-7006.2009.01261.x
19941816	EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.	Mol Cell	2009 Nov 25	Ji H	doi: 10.1016/j.molcel.2009.09.034.
26192076	Impaired formation of homotypic cell-in-cell structures in human tumor cells lacking alpha-catenin expression.	Sci Rep	2015 Jul 20	Wang M	doi: 10.1038/srep12223.
27487124	Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression.	Oncotarget	2016 Aug 23	Chen X	doi: 10.18632/oncotarget.10833.
19458087	Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells.	J Biol Chem	2009 Jul 3	Bajpai S	doi: 10.1074/jbc.M109.000661
22774602	[Expressions of E-cadherin and alpha-catenin in benign, malignant and metastatic prostate tumors].	Zhonghua Nan Ke Xue	2012 Jun	Jiang T	-
15297182	Marked allelic imbalance on chromosome 5q31 does not explain alpha-catenin expression in epithelial ovarian cancer.	Gynecol Oncol	2004 Aug	Tuhkanen H	-
23208944	An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.	J Pathol	2013 Mar	Majewski IJ	doi: 10.1002/path.4152.
24509793	α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-??B signalling.	Nat Cell Biol	2014 Mar	Piao HL	doi: 10.1038/ncb2909
19763817	Four human breast cancer cell lines with biallelic inactivating alpha-catenin gene mutations.	Breast Cancer Res Treat	2010 Jul	Hollestelle A	doi: 10.1007/s10549-009-0545-4
14599963	Relationship between expressions of E-cadherin and alpha-catenin and biological behaviors of human pancreatic cancer.	Hepatobiliary Pancreat Dis Int	2003 Aug	Li YJ	-
17760743	The prognostic value of E-cadherin, alpha-, beta- and gamma-catenin in bladder cancer patients who underwent radical cystectomy.	Int J Urol	2007 Sep	Kashibuchi K	-
20529814	The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis.	Folia Histochem Cytobiol	2010 Jan 1	Czyzewska J	doi: 10.2478/v10042-010-0017-z.
28790116	Targeted Proteomics Identifies Proteomic Signatures in Liquid Biopsies of the Endometrium to Diagnose Endometrial Cancer and Assist in the Prediction of the Optimal Surgical Treatment.	Clin Cancer Res	2017 Nov 1	Martinez-Garcia E	doi: 10.1158/1078-0432.CCR-17-0474

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr5	138930485	Nonsense_Mutation	novel	Q675*	0.1
BLCA	chr5	138810067	Missense_Mutation	rs769342340	F111L	0.24
BLCA	chr5	138812287	Nonsense_Mutation	novel	A191_A192insS*	0.11
BLCA	chr5	138824744	Missense_Mutation	novel	S268L	0.24
BLCA	chr5	138930827	Splice_Region	novel		0.4
BRCA	chr5	138929269	Silent	novel	S641S	0.08
BRCA	chr5	138810121	Nonsense_Mutation	rs758599826	R129*	0.42
BRCA	chr5	138934155	3'UTR	novel		0.1
BRCA	chr5	138887640	Missense_Mutation	NA	E432Q	0.18
BRCA	chr5	138924636	Missense_Mutation	NA	S558L	0.15
BRCA	chr5	138934092	3'UTR	novel		0.35
BRCA	chr5	138929245	Splice_Site	NA	X634_splice	0.25
BRCA	chr5	138783363	Nonsense_Mutation	NA	R98*	0.1
BRCA	chr5	138781957	Silent	NA	F11F	0.21
CESC	chr5	138932690	Missense_Mutation	novel	G804D	0.53
CESC	chr5	138929285	Missense_Mutation	NA	D647H	0.11
CESC	chr5	138932629	Missense_Mutation	NA	A784T	0.34
CESC	chr5	138932628	Silent	rs766188211	I783I	0.44
CESC	chr5	138917838	Missense_Mutation	rs754789006	R496C	0.32
COAD	chr5	138924659	Missense_Mutation	NA	G566R	0.32
COAD	chr5	138924615	Missense_Mutation	novel	R551L	0.31
COAD	chr5	138824598	Silent	rs751221688	P219P	0.39
COAD	chr5	138925365	Silent	NA	Y619Y	0.35
COAD	chr5	138934079	Missense_Mutation	NA	D904G	0.5
COAD	chr5	138933945	Nonsense_Mutation	novel	W859*	0.15
COAD	chr5	138783217	Missense_Mutation	NA	N49S	0.34
COAD	chr5	138904403	Nonsense_Mutation	rs201498915	R451*	0.53
COAD	chr5	138827711	Missense_Mutation	novel	M352T	0.27
COAD	chr5	138824602	Missense_Mutation	novel	L221I	0.24
COAD	chr5	138904390	Silent	novel	G446G	0.07
COAD	chr5	138783191	Frame_Shift_Del	novel	*N41Tfs54**	0.45
COAD	chr5	138812254	Frame_Shift_Del	novel	*K181Nfs7**	0.4
COAD	chr5	138934057	Missense_Mutation	novel	L897I	0.68
COAD	chr5	138925289	Missense_Mutation	novel	A594V	0.1
COAD	chr5	138932624	Missense_Mutation	NA	R782H	0.37
COAD	chr5	138930894	Nonsense_Mutation	novel	G753*	0.3
COAD	chr5	138917827	Frame_Shift_Del	NA	*K493Nfs31**	0.19
COAD	chr5	138933859	Frame_Shift_Del	NA	T832*	0.29
COAD	chr5	138827683	Missense_Mutation	novel	A343T	0.18
COAD	chr5	138924581	Missense_Mutation	novel	R540C	0.27
COAD	chr5	138824668	Missense_Mutation	NA	L243M	0.43
COAD	chr5	138904403	Nonsense_Mutation	rs201498915	R451*	0.14
COAD	chr5	138904427	Missense_Mutation	novel	A459T	0.08
COAD	chr5	138810041	Frame_Shift_Ins	novel	*L103Ffs12**	0.1
COAD	chr5	138932672	Missense_Mutation	NA	A798V	0.23
COAD	chr5	138934063	Missense_Mutation	NA	E899K	0.45
COAD	chr5	138782022	Missense_Mutation	novel	V33A	0.31
COAD	chr5	138783364	Missense_Mutation	rs746832628	R98Q	0.32
COAD	chr5	138886228	Missense_Mutation	novel	R360I	0.45
COAD	chr5	138934019	Missense_Mutation	NA	R884Q	0.35
COAD	chr5	138783364	Missense_Mutation	rs746832628	R98Q	0.07
COAD	chr5	138932624	Missense_Mutation	NA	R782H	0.24
COAD	chr5	138812184	Missense_Mutation	novel	V157A	0.04
COAD	chr5	138904403	Nonsense_Mutation	rs201498915	R451*	0.23
COAD	chr5	138917858	Silent	NA	V502V	0.21
COAD	chr5	138932676	Missense_Mutation	NA	E799D	0.29
ESCA	chr5	138930654	Missense_Mutation	NA	R731Q	0.42
ESCA	chr5	138930888	Missense_Mutation	novel	E751K	0.15
ESCA	chr5	138886272	Missense_Mutation	novel	T375A	0.27
ESCA	chr5	138886234	Missense_Mutation	novel	D362V	0.11
GBM	chr5	138886218	Missense_Mutation	rs758561244	R357C	0.17
GBM	chr5	138827707	Missense_Mutation	novel	Y351N	0.11
GBM	chr5	138917780	Missense_Mutation	novel	Q476H	0.04
GBM	chr5	138930901	Missense_Mutation	novel	R755M	0.35
HNSC	chr5	138925308	Silent	rs767250173	S600S	0.36
HNSC	chr5	138810134	Missense_Mutation	novel	S133C	0.31
HNSC	chr5	138886224	Missense_Mutation	novel	E359Q	0.51
HNSC	chr5	138930654	Missense_Mutation	NA	R731Q	0.18
HNSC	chr5	138924527	Missense_Mutation	novel	D522H	0.22
HNSC	chr5	138824656	Missense_Mutation	novel	A239S	0.4
HNSC	chr5	138810090	In_Frame_Ins	novel	V119dup	0.17
HNSC	chr5	138934111	3'UTR	novel		0.25
KIRC	chr5	138812185	Splice_Region	NA	V157V	0.25
KIRC	chr5	138933951	Missense_Mutation	NA	M861I	0.18
KIRC	chr5	138827621	Missense_Mutation	NA	S322L	0.21
KIRC	chr5	138934146	3'UTR	novel		0.14
KIRC	chr5	138925384	Silent	NA	R626R	0.12
KIRC	chr5	138783262	Missense_Mutation	NA	S64C	0.2
KIRC	chr5	138933942	In_Frame_Del	novel	W859del	0.22
KIRP	chr5	138932602	Missense_Mutation	NA	D775N	0.55
KIRP	chr5	138930641	Missense_Mutation	novel	T727A	0.44
KIRP	chr5	138783329	Silent	novel	L86L	0.54
KIRP	chr5	138930653	Nonsense_Mutation	NA	R731*	0.41
KIRP	chr5	138783207	Frame_Shift_Del	novel	*G46Afs3**	0.18
KIRP	chr5	138810179	Missense_Mutation	novel	Y148S	0.26
KIRP	chr5	138810180	Silent	novel	Y148Y	0.27
LAML	chr5	138810198	Silent	novel	L154L	0.1
LGG	chr5	138929278	Silent	novel	E644E	0.38
LIHC	chr5	138827623	Missense_Mutation	novel	S323P	0.35
LIHC	chr5	138930563	Nonsense_Mutation	NA	E701*	0.12
LIHC	chr5	138932678	Missense_Mutation	novel	V800E	0.36
LIHC	chr5	138924611	Missense_Mutation	novel	A550S	0.48
LIHC	chr5	138934047	Silent	rs1059181	P893P	0.62
LUAD	chr5	138930639	Missense_Mutation	novel	M726R	0.1
LUAD	chr5	138827676	Silent	novel	V340V	0.18
LUAD	chr5	138930521	Missense_Mutation	NA	Q687E	0.29
LUAD	chr5	138824574	Silent	novel	R211R	0.1
LUAD	chr5	138930517	Silent	rs372902176	A685A	0.36
LUAD	chr5	138824585	Missense_Mutation	novel	Q215L	0.06
LUAD	chr5	138933804	Splice_Region	NA	V812V	0.28
LUAD	chr5	138934075	Missense_Mutation	NA	M903V	0.16
LUAD	chr5	138783346	Missense_Mutation	novel	A92G	0.07
LUAD	chr5	138812294	Nonsense_Mutation	novel	R194*	0.25
LUAD	chr5	138924536	Nonsense_Mutation	novel	K525*	0.36
LUAD	chr5	138887507	Missense_Mutation	novel	M387I	0.31
LUAD	chr5	138812267	Missense_Mutation	novel	D185H	0.15
LUSC	chr5	138783371	Missense_Mutation	novel	Q100H	0.06
LUSC	chr5	138783373	Splice_Site	novel	X101_splice	0.07
LUSC	chr5	138932895	Intron	novel		0.13
LUSC	chr5	138925253	Splice_Region	novel		0.51
LUSC	chr5	138827556	Silent	novel	R300R	0.14
LUSC	chr5	138824789	Missense_Mutation	rs750584026	N283S	0.12
LUSC	chr5	138925257	Splice_Region	NA	V583V	0.34
LUSC	chr5	138904410	Missense_Mutation	novel	S453F	0.29
LUSC	chr5	138924604	Silent	novel	G547G	0.4
LUSC	chr5	138917752	Missense_Mutation	novel	A467D	0.19
LUSC	chr5	138932629	Missense_Mutation	NA	A784T	0.13
OV	chr5	138930549	In_Frame_Ins	novel	S696delinsRWAAGLQVLL	0.04
OV	chr5	138783246	Missense_Mutation	NA	H59Y	0.29
OV	chr5	138781925	Translation_Start_Site	NA	M1?	0.34
OV	chr5	138810097	Nonsense_Mutation	NA	R121*	0.11
PAAD	chr5	138827555	Missense_Mutation	rs369518072	R300H	0.22
PAAD	chr5	138886236	Missense_Mutation	novel	A363T	0.07
PAAD	chr5	138924582	Missense_Mutation	rs139655691	R540H	0.17
PAAD	chr5	138929261	Missense_Mutation	novel	D639N	0.07
PRAD	chr5	138783310	Missense_Mutation	rs200135015	A80V	0.33
PRAD	chr5	138934038	Silent	rs528674508	H890H	0.21
READ	chr5	138933987	Missense_Mutation	rs376239375	E873D	0.28
READ	chr5	138924582	Missense_Mutation	rs139655691	R540H	0.44
READ	chr5	138781973	Missense_Mutation	novel	S17R	0.35
SARC	chr5	138932692	Missense_Mutation	NA	G805R	0.3
SARC	chr5	138932693	Missense_Mutation	novel	G805E	0.29
SKCM	chr5	138827607	Silent	novel	A317A	0.28
SKCM	chr5	138827702	Missense_Mutation	rs201056930	S349L	0.24
SKCM	chr5	138917859	Missense_Mutation	NA	D503N	0.23
SKCM	chr5	138930831	Missense_Mutation	novel	G732S	0.35
SKCM	chr5	138783336	Missense_Mutation	rs780367865	E89K	0.4
SKCM	chr5	138782018	Missense_Mutation	NA	L32F	0.37
SKCM	chr5	138925290	Silent	rs142503438	A594A	0.89
SKCM	chr5	138824604	Silent	rs552540254	L221L	0.17
STAD	chr5	138934046	Missense_Mutation	NA	P893L	0.33
STAD	chr5	138917827	Frame_Shift_Del	NA	*K493Nfs31**	0.27
STAD	chr5	138932645	Missense_Mutation	NA	Q789R	0.3
STAD	chr5	138932654	Missense_Mutation	NA	I792N	0.61
STAD	chr5	138810121	Nonsense_Mutation	rs758599826	R129*	0.43
STAD	chr5	138930846	Frame_Shift_Del	novel	*N738Ifs53**	0.33
STAD	chr5	138810196	Silent	novel	L154L	0.14
STAD	chr5	138934121	3'UTR	novel		0.15
STAD	chr5	138930654	Missense_Mutation	NA	R731Q	0.29
STAD	chr5	138824757	Silent	NA	G272G	0.24
STAD	chr5	138783248	Silent	NA	H59H	0.33
STAD	chr5	138824618	Missense_Mutation	NA	Q226R	0.3
STAD	chr5	138824737	Missense_Mutation	NA	D266N	0.35
STAD	chr5	138930621	Missense_Mutation	novel	C720Y	0.37
STAD	chr5	138824551	Missense_Mutation	rs748407995	R204C	0.16
STAD	chr5	138783364	Missense_Mutation	rs746832628	R98Q	0.31
STAD	chr5	138930507	Missense_Mutation	novel	A682V	0.28
STAD	chr5	138917827	Frame_Shift_Del	NA	*K493Nfs31**	0.22
STAD	chr5	138925266	Frame_Shift_Del	novel	*F587Lfs5**	0.21
STAD	chr5	138925266	Frame_Shift_Del	novel	*F587Lfs5**	0.23
STAD	chr5	138933898	Nonsense_Mutation	NA	Q844*	0.17
STAD	chr5	138932902	Intron	rs747180959		0.33
STAD	chr5	138917858	Silent	NA	V502V	0.07
STAD	chr5	138929264	Frame_Shift_Del	novel	*S641Rfs4**	0.08
STAD	chr5	138933896	Missense_Mutation	NA	Y843C	0.14
STAD	chr5	138824586	Missense_Mutation	NA	Q215H	0.23
THYM	chr5	138827632	Missense_Mutation	novel	R326C	0.16
UCEC	chr5	138810097	Nonsense_Mutation	NA	R121*	0.34
UCEC	chr5	138887589	Nonsense_Mutation	NA	E415*	0.29
UCEC	chr5	138824644	Missense_Mutation	rs548392885	A235T	0.46
UCEC	chr5	138887565	Missense_Mutation	novel	A407S	0.33
UCEC	chr5	138917863	Missense_Mutation	rs746486077	D504G	0.42
UCEC	chr5	138783364	Missense_Mutation	rs746832628	R98Q	0.08
UCEC	chr5	138824770	Nonsense_Mutation	NA	E277*	0.35
UCEC	chr5	138930654	Missense_Mutation	NA	R731Q	0.39
UCEC	chr5	138827650	Nonsense_Mutation	NA	R332*	0.3
UCEC	chr5	138824684	In_Frame_Ins	NA	Q250dup	0.3
UCEC	chr5	138887638	Missense_Mutation	novel	I431T	0.05
UCEC	chr5	138783207	Missense_Mutation	rs751978245	G46W	0.05
UCEC	chr5	138824799	Splice_Region	rs779989605	D286D	0.27
UCEC	chr5	138824800	Splice_Site	NA	X286_splice	0.38
UCEC	chr5	138904403	Nonsense_Mutation	rs201498915	R451*	0.28
UCEC	chr5	138812234	Nonsense_Mutation	rs761836161	G174*	0.13
UCEC	chr5	138932605	Missense_Mutation	NA	L776M	0.24
UCEC	chr5	138917827	Frame_Shift_Del	NA	*K493Nfs31**	0.05
UCEC	chr5	138925388	Missense_Mutation	NA	K627R	0.4
UCEC	chr5	138887573	Missense_Mutation	NA	K409N	0.27
UCEC	chr5	138824770	Nonsense_Mutation	NA	E277*	0.42
UCEC	chr5	138887589	Nonsense_Mutation	NA	E415*	0.31
UCEC	chr5	138934017	Silent	novel	K883K	0.7
UCEC	chr5	138934614	3'UTR	novel		0.44
UCEC	chr5	138824552	Missense_Mutation	novel	R204H	0.36
UCEC	chr5	138925375	Missense_Mutation	novel	R623W	0.35
UCEC	chr5	138932673	Silent	rs752347559	A798A	0.42
UCEC	chr5	138933879	Silent	rs768589719	Y837Y	0.3
UCEC	chr5	138934038	Silent	rs528674508	H890H	0.24
UCEC	chr5	138824563	Missense_Mutation	novel	A208T	0.43
UCEC	chr5	138932692	Missense_Mutation	NA	G805R	0.27
UCEC	chr5	138824737	Missense_Mutation	NA	D266N	0.32
UCEC	chr5	138810066	Missense_Mutation	NA	E110D	0.45
UCEC	chr5	138812228	Missense_Mutation	novel	D172N	0.33
UCEC	chr5	138904395	Missense_Mutation	NA	K448T	0.18
UCEC	chr5	138887524	Missense_Mutation	novel	S393Y	0.38
UCEC	chr5	138917798	Missense_Mutation	novel	E482D	0.27
UCEC	chr5	138932703	Silent	rs746478233	V808V	0.26
UCEC	chr5	138934066	Missense_Mutation	novel	F900L	0.27
UCEC	chr5	138924605	Missense_Mutation	novel	R548W	0.27
UCEC	chr5	138924599	Nonsense_Mutation	novel	R546*	0.41
UCEC	chr5	138934773	3'UTR	novel		0.32
UCEC	chr5	138932624	Missense_Mutation	NA	R782H	0.46
UCEC	chr5	138934622	3'UTR	novel		0.31
UCEC	chr5	138924563	Missense_Mutation	novel	D534N	0.43
UCEC	chr5	138932915	Intron	novel		0.31
UCEC	chr5	138824688	Silent	novel	Q249Q	0.3
UCEC	chr5	138887642	Splice_Region	novel	E432E	0.24
UCEC	chr5	138887589	Nonsense_Mutation	NA	E415*	0.18
UCEC	chr5	138781970	Missense_Mutation	rs759641978	K16E	0.39
UCEC	chr5	138824647	Missense_Mutation	NA	A236T	0.16
UCEC	chr5	138827628	Silent	NA	C324C	0.42
UCEC	chr5	138886285	Missense_Mutation	rs760356703	R379H	0.44
UCEC	chr5	138781922	Splice_Site	NA		0.41
UCEC	chr5	138904403	Nonsense_Mutation	rs201498915	R451*	0.33
UCEC	chr5	138904403	Nonsense_Mutation	rs201498915	R451*	0.22
UCEC	chr5	138932584	Missense_Mutation	novel	D769N	0.28
UCEC	chr5	138934701	3'UTR	novel		0.31
UCEC	chr5	138932690	Missense_Mutation	novel	G804D	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	AMP	0.1111	0.069756
KIRP	DEL	0.0417	0.11554
LAML	DEL	0.089	1.2971e-07
LUSC	DEL	0.6188	0.002071
MESO	DEL	0.1264	0.20184
PRAD	AMP	0.0346	0.16448
SKCM	DEL	0.2916	2.2081e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
THYM	0.017	Kaplan-Meier Survival Analysis
BRCA	0.01	Kaplan-Meier Survival Analysis
KIRP	0.05	Kaplan-Meier Survival Analysis
COAD	0.0003	Kaplan-Meier Survival Analysis
PAAD	0.0013	Kaplan-Meier Survival Analysis
READ	0.02	Kaplan-Meier Survival Analysis
KICH	0.031	Kaplan-Meier Survival Analysis
LIHC	0.0012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000044115 (Gene tree)
Gene ID: 1495
Gene Symbol: CTNNA1
Alias: CAP102
Full Name: catenin alpha 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 324,068 bases
Position: chr5:138,610,967-138,935,034
Accession: 2509
RBP type: non-canonical RBP
Summary: This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000522013	CTNNA1-232	874	-	ENSP00000430379	105 (aa)	-	E5RFK9
ENST00000517534	CTNNA1-203	416	-	-	- (aa)	-	-
ENST00000521640	CTNNA1-228	568	-	ENSP00000430623	40 (aa)	-	E5RJ43
ENST00000521387	CTNNA1-227	871	-	-	- (aa)	-	-
ENST00000517533	CTNNA1-202	579	-	ENSP00000431118	119 (aa)	-	E5RJP7
ENST00000521683	CTNNA1-229	565	-	ENSP00000430981	71 (aa)	-	E5RGU3
ENST00000519113	CTNNA1-213	859	-	ENSP00000430078	139 (aa)	-	E5RGY6
ENST00000518585	CTNNA1-209	568	-	-	- (aa)	-	-
ENST00000519116	CTNNA1-214	562	-	ENSP00000428894	91 (aa)	-	E5RFG3
ENST00000521724	CTNNA1-230	2741	-	ENSP00000431033	37 (aa)	-	E5RJZ2
ENST00000524292	CTNNA1-242	557	-	-	- (aa)	-	-
ENST00000519489	CTNNA1-216	358	-	-	- (aa)	-	-
ENST00000519634	CTNNA1-217	589	-	ENSP00000428088	50 (aa)	-	E5RGS1
ENST00000302763	CTNNA1-201	3756	-	ENSP00000304669	906 (aa)	-	P35221
ENST00000519768	CTNNA1-218	560	-	ENSP00000429103	20 (aa)	-	E5RJC9
ENST00000520158	CTNNA1-219	719	-	ENSP00000429457	215 (aa)	-	E5RIB1
ENST00000520339	CTNNA1-221	868	-	ENSP00000428202	101 (aa)	-	E5RJL0
ENST00000524127	CTNNA1-241	483	-	ENSP00000428049	94 (aa)	-	E5RFM3
ENST00000517904	CTNNA1-205	661	-	-	- (aa)	-	-
ENST00000520400	CTNNA1-222	589	-	-	- (aa)	-	-
ENST00000520520	CTNNA1-223	484	-	ENSP00000430076	136 (aa)	-	E5RGY7
ENST00000520522	CTNNA1-224	390	-	ENSP00000428710	50 (aa)	-	E5RGS1
ENST00000523685	CTNNA1-239	694	-	ENSP00000430240	128 (aa)	-	E5RGD2
ENST00000518825	CTNNA1-210	3536	-	ENSP00000427821	841 (aa)	-	G3XAM7
ENST00000523298	CTNNA1-238	577	-	ENSP00000428044	110 (aa)	-	E5RFM5
ENST00000517980	CTNNA1-206	696	-	ENSP00000428439	117 (aa)	-	E5RIE0
ENST00000627109	CTNNA1-244	3831	-	ENSP00000486200	841 (aa)	-	G3XAM7
ENST00000518263	CTNNA1-207	548	-	-	- (aa)	-	-
ENST00000517656	CTNNA1-204	554	-	ENSP00000430177	39 (aa)	-	E5RGG4
ENST00000519309	CTNNA1-215	869	-	ENSP00000430671	55 (aa)	-	E5RIT8
ENST00000521368	CTNNA1-226	544	-	ENSP00000428686	22 (aa)	-	H0YB54
ENST00000540387	CTNNA1-243	2684	-	ENSP00000438476	536 (aa)	-	P35221
ENST00000520865	CTNNA1-225	557	-	ENSP00000430841	36 (aa)	-	E5RHR7
ENST00000523275	CTNNA1-237	536	-	ENSP00000429142	129 (aa)	-	H0YBB8
ENST00000522227	CTNNA1-234	642	-	ENSP00000429636	123 (aa)	-	E5RHV7
ENST00000521941	CTNNA1-231	224	-	-	- (aa)	-	-
ENST00000518910	CTNNA1-211	572	-	ENSP00000430626	161 (aa)	-	E5RJ41
ENST00000518381	CTNNA1-208	487	-	ENSP00000429738	75 (aa)	-	E5RHJ5
ENST00000522792	CTNNA1-236	2044	-	-	- (aa)	-	-
ENST00000518919	CTNNA1-212	498	-	-	- (aa)	-	-
ENST00000522730	CTNNA1-235	750	-	-	- (aa)	-	-
ENST00000523912	CTNNA1-240	545	-	ENSP00000430304	156 (aa)	-	E5RG03
ENST00000522052	CTNNA1-233	579	-	ENSP00000482738	64 (aa)	-	A0A087WZL6
ENST00000520260	CTNNA1-220	710	-	ENSP00000429569	32 (aa)	-	E5RHY5

Gene Model

Click here to download ENSG00000044115's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04390	Hippo signaling pathway	KEGG
hsa04520	Adherens junction	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa05100	Bacterial invasion of epithelial cells	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05213	Endometrial cancer	KEGG
hsa05226	Gastric cancer	KEGG
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000044115	Carotid Stenosis	1.22782466839139E-6	17903303
ENSG00000044115	Carotid Stenosis	2.66929697702384E-11	17903303
ENSG00000044115	Blood Pressure	3.30294116364036E-7	17903302
ENSG00000044115	Blood Pressure	9.61857522857645E-6	17903302

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000044115	rs10043722	5	138901252	A	General risk tolerance (MTAG)	30643258	[0.0059-0.0107] unit decrease	0.0083	EFO_0008579
ENSG00000044115	rs114916656	5	138671837	T	General risk tolerance (MTAG)	30643258	[0.0079-0.0165] unit decrease	0.0122	EFO_0008579

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000044115's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000044115	CTNNA1	95	32.075	ENSG00000035403	VCL	54	38.614	Homo_sapiens
ENSG00000044115	CTNNA1	100	100.000	ENSMUSG00000037815	Ctnna1	100	99.448	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001541	ovarian follicle development	-	IEA	Process
GO:0001669	acrosomal vesicle	-	IEA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005198	structural molecule activity	-	IEA	Function
GO:0005515	protein binding	12477722.15657067.16212417.17098867.17620599.18093941.19016843.20936779.22750944.23292143.24189400.24509793.25241761.25764135.26496610.28051089.	IPI	Function
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005911	cell-cell junction	7650039.10460003.	IDA	Component
GO:0005915	zonula adherens	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007015	actin filament organization	-	IEA	Process
GO:0007155	cell adhesion	8323564.	NAS	Process
GO:0007163	establishment or maintenance of cell polarity	-	IEA	Process
GO:0007406	negative regulation of neuroblast proliferation	-	IEA	Process
GO:0007568	aging	-	IEA	Process
GO:0008013	beta-catenin binding	7650039.7890674.	IPI	Function
GO:0008584	male gonad development	-	IEA	Process
GO:0014704	intercalated disc	-	IEA	Component
GO:0015629	actin cytoskeleton	-	IEA	Component
GO:0016264	gap junction assembly	-	IEA	Process
GO:0016342	catenin complex	7650039.28051089.	IDA	Component
GO:0016600	flotillin complex	-	IEA	Component
GO:0017166	vinculin binding	9700171.	IPI	Function
GO:0030027	lamellipodium	-	IEA	Component
GO:0030054	cell junction	-	IDA	Component
GO:0031103	axon regeneration	-	IEA	Process
GO:0034332	adherens junction organization	-	TAS	Process
GO:0034613	cellular protein localization	-	IEA	Process
GO:0042475	odontogenesis of dentin-containing tooth	-	IEA	Process
GO:0042802	identical protein binding	23292143.	IPI	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043297	apical junction assembly	9700171.	NAS	Process
GO:0043627	response to estrogen	-	IEA	Process
GO:0045295	gamma-catenin binding	7650039.7890674.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045296	cadherin binding	7650039.12734196.	IPI	Function
GO:0045880	positive regulation of smoothened signaling pathway	-	IEA	Process
GO:0046982	protein heterodimerization activity	-	IEA	Function
GO:0051015	actin filament binding	-	IEA	Function
GO:0051149	positive regulation of muscle cell differentiation	-	TAS	Process
GO:0051291	protein heterooligomerization	-	IEA	Process
GO:0071681	cellular response to indole-3-methanol	10868478.	IDA	Process
GO:0090136	epithelial cell-cell adhesion	-	IEA	Process
GO:2000146	negative regulation of cell motility	-	IEA	Process
GO:2001045	negative regulation of integrin-mediated signaling pathway	-	IEA	Process
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	Process
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	-	IEA	Process

EuRBPDB

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Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.