EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25483184α-catenin. A tumor suppressor beyond adherens junctions.Cell Cycle2014Sun Ydoi: 10.4161/cc.29765.
18566211alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling.Mol Cancer Ther2008 JunInge LJdoi: 10.1158/1535-7163.MCT-07-2029.
22469663Identification of a Wnt-induced protein complex by affinity proteomics using an antibody that recognizes a sub-population of β-catenin.Biochim Biophys Acta2012 JulLayton MJdoi: 10.1016/j.bbapap.2012.03.006
19656157Tumor suppressor function of BCSC-1 in nasopharyngeal carcinoma.Cancer Sci2009 OctZhou YQdoi: 10.1111/j.1349-7006.2009.01261.x
19941816EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.Mol Cell2009 Nov 25Ji Hdoi: 10.1016/j.molcel.2009.09.034.
26192076Impaired formation of homotypic cell-in-cell structures in human tumor cells lacking alpha-catenin expression.Sci Rep2015 Jul 20Wang Mdoi: 10.1038/srep12223.
27487124Downregulated pseudogene CTNNAP1 promote tumor growth in human cancer by downregulating its cognate gene CTNNA1 expression.Oncotarget2016 Aug 23Chen Xdoi: 10.18632/oncotarget.10833.
19458087Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells.J Biol Chem2009 Jul 3Bajpai Sdoi: 10.1074/jbc.M109.000661
22774602[Expressions of E-cadherin and alpha-catenin in benign, malignant and metastatic prostate tumors].Zhonghua Nan Ke Xue2012 JunJiang T-
15297182Marked allelic imbalance on chromosome 5q31 does not explain alpha-catenin expression in epithelial ovarian cancer.Gynecol Oncol2004 AugTuhkanen H-
23208944An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.J Pathol2013 MarMajewski IJdoi: 10.1002/path.4152.
24509793α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-??B signalling.Nat Cell Biol2014 MarPiao HLdoi: 10.1038/ncb2909
19763817Four human breast cancer cell lines with biallelic inactivating alpha-catenin gene mutations.Breast Cancer Res Treat2010 JulHollestelle Adoi: 10.1007/s10549-009-0545-4
14599963Relationship between expressions of E-cadherin and alpha-catenin and biological behaviors of human pancreatic cancer.Hepatobiliary Pancreat Dis Int2003 AugLi YJ-
17760743The prognostic value of E-cadherin, alpha-, beta- and gamma-catenin in bladder cancer patients who underwent radical cystectomy.Int J Urol2007 SepKashibuchi K-
20529814The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis.Folia Histochem Cytobiol2010 Jan 1Czyzewska Jdoi: 10.2478/v10042-010-0017-z.
28790116Targeted Proteomics Identifies Proteomic Signatures in Liquid Biopsies of the Endometrium to Diagnose Endometrial Cancer and Assist in the Prediction of the Optimal Surgical Treatment.Clin Cancer Res2017 Nov 1Martinez-Garcia Edoi: 10.1158/1078-0432.CCR-17-0474

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr5138930485Nonsense_MutationnovelQ675*0.1
BLCAchr5138810067Missense_Mutationrs769342340F111L0.24
BLCAchr5138812287Nonsense_MutationnovelA191_A192insS*0.11
BLCAchr5138824744Missense_MutationnovelS268L0.24
BLCAchr5138930827Splice_Regionnovel0.4
BRCAchr5138929269SilentnovelS641S0.08
BRCAchr5138810121Nonsense_Mutationrs758599826R129*0.42
BRCAchr51389341553'UTRnovel0.1
BRCAchr5138887640Missense_MutationNAE432Q0.18
BRCAchr5138924636Missense_MutationNAS558L0.15
BRCAchr51389340923'UTRnovel0.35
BRCAchr5138929245Splice_SiteNAX634_splice0.25
BRCAchr5138783363Nonsense_MutationNAR98*0.1
BRCAchr5138781957SilentNAF11F0.21
CESCchr5138932690Missense_MutationnovelG804D0.53
CESCchr5138929285Missense_MutationNAD647H0.11
CESCchr5138932629Missense_MutationNAA784T0.34
CESCchr5138932628Silentrs766188211I783I0.44
CESCchr5138917838Missense_Mutationrs754789006R496C0.32
COADchr5138924659Missense_MutationNAG566R0.32
COADchr5138924615Missense_MutationnovelR551L0.31
COADchr5138824598Silentrs751221688P219P0.39
COADchr5138925365SilentNAY619Y0.35
COADchr5138934079Missense_MutationNAD904G0.5
COADchr5138933945Nonsense_MutationnovelW859*0.15
COADchr5138783217Missense_MutationNAN49S0.34
COADchr5138904403Nonsense_Mutationrs201498915R451*0.53
COADchr5138827711Missense_MutationnovelM352T0.27
COADchr5138824602Missense_MutationnovelL221I0.24
COADchr5138904390SilentnovelG446G0.07
COADchr5138783191Frame_Shift_DelnovelN41Tfs*540.45
COADchr5138812254Frame_Shift_DelnovelK181Nfs*70.4
COADchr5138934057Missense_MutationnovelL897I0.68
COADchr5138925289Missense_MutationnovelA594V0.1
COADchr5138932624Missense_MutationNAR782H0.37
COADchr5138930894Nonsense_MutationnovelG753*0.3
COADchr5138917827Frame_Shift_DelNAK493Nfs*310.19
COADchr5138933859Frame_Shift_DelNAT832*0.29
COADchr5138827683Missense_MutationnovelA343T0.18
COADchr5138924581Missense_MutationnovelR540C0.27
COADchr5138824668Missense_MutationNAL243M0.43
COADchr5138904403Nonsense_Mutationrs201498915R451*0.14
COADchr5138904427Missense_MutationnovelA459T0.08
COADchr5138810041Frame_Shift_InsnovelL103Ffs*120.1
COADchr5138932672Missense_MutationNAA798V0.23
COADchr5138934063Missense_MutationNAE899K0.45
COADchr5138782022Missense_MutationnovelV33A0.31
COADchr5138783364Missense_Mutationrs746832628R98Q0.32
COADchr5138886228Missense_MutationnovelR360I0.45
COADchr5138934019Missense_MutationNAR884Q0.35
COADchr5138783364Missense_Mutationrs746832628R98Q0.07
COADchr5138932624Missense_MutationNAR782H0.24
COADchr5138812184Missense_MutationnovelV157A0.04
COADchr5138904403Nonsense_Mutationrs201498915R451*0.23
COADchr5138917858SilentNAV502V0.21
COADchr5138932676Missense_MutationNAE799D0.29
ESCAchr5138930654Missense_MutationNAR731Q0.42
ESCAchr5138930888Missense_MutationnovelE751K0.15
ESCAchr5138886272Missense_MutationnovelT375A0.27
ESCAchr5138886234Missense_MutationnovelD362V0.11
GBMchr5138886218Missense_Mutationrs758561244R357C0.17
GBMchr5138827707Missense_MutationnovelY351N0.11
GBMchr5138917780Missense_MutationnovelQ476H0.04
GBMchr5138930901Missense_MutationnovelR755M0.35
HNSCchr5138925308Silentrs767250173S600S0.36
HNSCchr5138810134Missense_MutationnovelS133C0.31
HNSCchr5138886224Missense_MutationnovelE359Q0.51
HNSCchr5138930654Missense_MutationNAR731Q0.18
HNSCchr5138924527Missense_MutationnovelD522H0.22
HNSCchr5138824656Missense_MutationnovelA239S0.4
HNSCchr5138810090In_Frame_InsnovelV119dup0.17
HNSCchr51389341113'UTRnovel0.25
KIRCchr5138812185Splice_RegionNAV157V0.25
KIRCchr5138933951Missense_MutationNAM861I0.18
KIRCchr5138827621Missense_MutationNAS322L0.21
KIRCchr51389341463'UTRnovel0.14
KIRCchr5138925384SilentNAR626R0.12
KIRCchr5138783262Missense_MutationNAS64C0.2
KIRCchr5138933942In_Frame_DelnovelW859del0.22
KIRPchr5138932602Missense_MutationNAD775N0.55
KIRPchr5138930641Missense_MutationnovelT727A0.44
KIRPchr5138783329SilentnovelL86L0.54
KIRPchr5138930653Nonsense_MutationNAR731*0.41
KIRPchr5138783207Frame_Shift_DelnovelG46Afs*30.18
KIRPchr5138810179Missense_MutationnovelY148S0.26
KIRPchr5138810180SilentnovelY148Y0.27
LAMLchr5138810198SilentnovelL154L0.1
LGGchr5138929278SilentnovelE644E0.38
LIHCchr5138827623Missense_MutationnovelS323P0.35
LIHCchr5138930563Nonsense_MutationNAE701*0.12
LIHCchr5138932678Missense_MutationnovelV800E0.36
LIHCchr5138924611Missense_MutationnovelA550S0.48
LIHCchr5138934047Silentrs1059181P893P0.62
LUADchr5138930639Missense_MutationnovelM726R0.1
LUADchr5138827676SilentnovelV340V0.18
LUADchr5138930521Missense_MutationNAQ687E0.29
LUADchr5138824574SilentnovelR211R0.1
LUADchr5138930517Silentrs372902176A685A0.36
LUADchr5138824585Missense_MutationnovelQ215L0.06
LUADchr5138933804Splice_RegionNAV812V0.28
LUADchr5138934075Missense_MutationNAM903V0.16
LUADchr5138783346Missense_MutationnovelA92G0.07
LUADchr5138812294Nonsense_MutationnovelR194*0.25
LUADchr5138924536Nonsense_MutationnovelK525*0.36
LUADchr5138887507Missense_MutationnovelM387I0.31
LUADchr5138812267Missense_MutationnovelD185H0.15
LUSCchr5138783371Missense_MutationnovelQ100H0.06
LUSCchr5138783373Splice_SitenovelX101_splice0.07
LUSCchr5138932895Intronnovel0.13
LUSCchr5138925253Splice_Regionnovel0.51
LUSCchr5138827556SilentnovelR300R0.14
LUSCchr5138824789Missense_Mutationrs750584026N283S0.12
LUSCchr5138925257Splice_RegionNAV583V0.34
LUSCchr5138904410Missense_MutationnovelS453F0.29
LUSCchr5138924604SilentnovelG547G0.4
LUSCchr5138917752Missense_MutationnovelA467D0.19
LUSCchr5138932629Missense_MutationNAA784T0.13
OVchr5138930549In_Frame_InsnovelS696delinsRWAAGLQVLL0.04
OVchr5138783246Missense_MutationNAH59Y0.29
OVchr5138781925Translation_Start_SiteNAM1?0.34
OVchr5138810097Nonsense_MutationNAR121*0.11
PAADchr5138827555Missense_Mutationrs369518072R300H0.22
PAADchr5138886236Missense_MutationnovelA363T0.07
PAADchr5138924582Missense_Mutationrs139655691R540H0.17
PAADchr5138929261Missense_MutationnovelD639N0.07
PRADchr5138783310Missense_Mutationrs200135015A80V0.33
PRADchr5138934038Silentrs528674508H890H0.21
READchr5138933987Missense_Mutationrs376239375E873D0.28
READchr5138924582Missense_Mutationrs139655691R540H0.44
READchr5138781973Missense_MutationnovelS17R0.35
SARCchr5138932692Missense_MutationNAG805R0.3
SARCchr5138932693Missense_MutationnovelG805E0.29
SKCMchr5138827607SilentnovelA317A0.28
SKCMchr5138827702Missense_Mutationrs201056930S349L0.24
SKCMchr5138917859Missense_MutationNAD503N0.23
SKCMchr5138930831Missense_MutationnovelG732S0.35
SKCMchr5138783336Missense_Mutationrs780367865E89K0.4
SKCMchr5138782018Missense_MutationNAL32F0.37
SKCMchr5138925290Silentrs142503438A594A0.89
SKCMchr5138824604Silentrs552540254L221L0.17
STADchr5138934046Missense_MutationNAP893L0.33
STADchr5138917827Frame_Shift_DelNAK493Nfs*310.27
STADchr5138932645Missense_MutationNAQ789R0.3
STADchr5138932654Missense_MutationNAI792N0.61
STADchr5138810121Nonsense_Mutationrs758599826R129*0.43
STADchr5138930846Frame_Shift_DelnovelN738Ifs*530.33
STADchr5138810196SilentnovelL154L0.14
STADchr51389341213'UTRnovel0.15
STADchr5138930654Missense_MutationNAR731Q0.29
STADchr5138824757SilentNAG272G0.24
STADchr5138783248SilentNAH59H0.33
STADchr5138824618Missense_MutationNAQ226R0.3
STADchr5138824737Missense_MutationNAD266N0.35
STADchr5138930621Missense_MutationnovelC720Y0.37
STADchr5138824551Missense_Mutationrs748407995R204C0.16
STADchr5138783364Missense_Mutationrs746832628R98Q0.31
STADchr5138930507Missense_MutationnovelA682V0.28
STADchr5138917827Frame_Shift_DelNAK493Nfs*310.22
STADchr5138925266Frame_Shift_DelnovelF587Lfs*50.21
STADchr5138925266Frame_Shift_DelnovelF587Lfs*50.23
STADchr5138933898Nonsense_MutationNAQ844*0.17
STADchr5138932902Intronrs7471809590.33
STADchr5138917858SilentNAV502V0.07
STADchr5138929264Frame_Shift_DelnovelS641Rfs*40.08
STADchr5138933896Missense_MutationNAY843C0.14
STADchr5138824586Missense_MutationNAQ215H0.23
THYMchr5138827632Missense_MutationnovelR326C0.16
UCECchr5138810097Nonsense_MutationNAR121*0.34
UCECchr5138887589Nonsense_MutationNAE415*0.29
UCECchr5138824644Missense_Mutationrs548392885A235T0.46
UCECchr5138887565Missense_MutationnovelA407S0.33
UCECchr5138917863Missense_Mutationrs746486077D504G0.42
UCECchr5138783364Missense_Mutationrs746832628R98Q0.08
UCECchr5138824770Nonsense_MutationNAE277*0.35
UCECchr5138930654Missense_MutationNAR731Q0.39
UCECchr5138827650Nonsense_MutationNAR332*0.3
UCECchr5138824684In_Frame_InsNAQ250dup0.3
UCECchr5138887638Missense_MutationnovelI431T0.05
UCECchr5138783207Missense_Mutationrs751978245G46W0.05
UCECchr5138824799Splice_Regionrs779989605D286D0.27
UCECchr5138824800Splice_SiteNAX286_splice0.38
UCECchr5138904403Nonsense_Mutationrs201498915R451*0.28
UCECchr5138812234Nonsense_Mutationrs761836161G174*0.13
UCECchr5138932605Missense_MutationNAL776M0.24
UCECchr5138917827Frame_Shift_DelNAK493Nfs*310.05
UCECchr5138925388Missense_MutationNAK627R0.4
UCECchr5138887573Missense_MutationNAK409N0.27
UCECchr5138824770Nonsense_MutationNAE277*0.42
UCECchr5138887589Nonsense_MutationNAE415*0.31
UCECchr5138934017SilentnovelK883K0.7
UCECchr51389346143'UTRnovel0.44
UCECchr5138824552Missense_MutationnovelR204H0.36
UCECchr5138925375Missense_MutationnovelR623W0.35
UCECchr5138932673Silentrs752347559A798A0.42
UCECchr5138933879Silentrs768589719Y837Y0.3
UCECchr5138934038Silentrs528674508H890H0.24
UCECchr5138824563Missense_MutationnovelA208T0.43
UCECchr5138932692Missense_MutationNAG805R0.27
UCECchr5138824737Missense_MutationNAD266N0.32
UCECchr5138810066Missense_MutationNAE110D0.45
UCECchr5138812228Missense_MutationnovelD172N0.33
UCECchr5138904395Missense_MutationNAK448T0.18
UCECchr5138887524Missense_MutationnovelS393Y0.38
UCECchr5138917798Missense_MutationnovelE482D0.27
UCECchr5138932703Silentrs746478233V808V0.26
UCECchr5138934066Missense_MutationnovelF900L0.27
UCECchr5138924605Missense_MutationnovelR548W0.27
UCECchr5138924599Nonsense_MutationnovelR546*0.41
UCECchr51389347733'UTRnovel0.32
UCECchr5138932624Missense_MutationNAR782H0.46
UCECchr51389346223'UTRnovel0.31
UCECchr5138924563Missense_MutationnovelD534N0.43
UCECchr5138932915Intronnovel0.31
UCECchr5138824688SilentnovelQ249Q0.3
UCECchr5138887642Splice_RegionnovelE432E0.24
UCECchr5138887589Nonsense_MutationNAE415*0.18
UCECchr5138781970Missense_Mutationrs759641978K16E0.39
UCECchr5138824647Missense_MutationNAA236T0.16
UCECchr5138827628SilentNAC324C0.42
UCECchr5138886285Missense_Mutationrs760356703R379H0.44
UCECchr5138781922Splice_SiteNA0.41
UCECchr5138904403Nonsense_Mutationrs201498915R451*0.33
UCECchr5138904403Nonsense_Mutationrs201498915R451*0.22
UCECchr5138932584Missense_MutationnovelD769N0.28
UCECchr51389347013'UTRnovel0.31
UCECchr5138932690Missense_MutationnovelG804D0.36

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPAMP0.11110.069756
KIRPDEL0.04170.11554
LAMLDEL0.0891.2971e-07
LUSCDEL0.61880.002071
MESODEL0.12640.20184
PRADAMP0.03460.16448
SKCMDEL0.29162.2081e-08
THCAAMP0.03610.075436
THCADEL00.23456

Survival Analysis
CancerP-value Q-value
THYM0.017

Kaplan-Meier Survival Analysis

BRCA0.01

Kaplan-Meier Survival Analysis

KIRP0.05

Kaplan-Meier Survival Analysis

COAD0.0003

Kaplan-Meier Survival Analysis

PAAD0.0013

Kaplan-Meier Survival Analysis

READ0.02

Kaplan-Meier Survival Analysis

KICH0.031

Kaplan-Meier Survival Analysis

LIHC0.0012

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000044115 (Gene tree)
Gene ID
1495
Gene Symbol
CTNNA1
Alias
CAP102
Full Name
catenin alpha 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
324,068 bases
Position
chr5:138,610,967-138,935,034
Accession
2509
RBP type
non-canonical RBP
Summary
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000522013CTNNA1-232874-ENSP00000430379105 (aa)-E5RFK9
ENST00000517534CTNNA1-203416--- (aa)--
ENST00000521640CTNNA1-228568-ENSP0000043062340 (aa)-E5RJ43
ENST00000521387CTNNA1-227871--- (aa)--
ENST00000517533CTNNA1-202579-ENSP00000431118119 (aa)-E5RJP7
ENST00000521683CTNNA1-229565-ENSP0000043098171 (aa)-E5RGU3
ENST00000519113CTNNA1-213859-ENSP00000430078139 (aa)-E5RGY6
ENST00000518585CTNNA1-209568--- (aa)--
ENST00000519116CTNNA1-214562-ENSP0000042889491 (aa)-E5RFG3
ENST00000521724CTNNA1-2302741-ENSP0000043103337 (aa)-E5RJZ2
ENST00000524292CTNNA1-242557--- (aa)--
ENST00000519489CTNNA1-216358--- (aa)--
ENST00000519634CTNNA1-217589-ENSP0000042808850 (aa)-E5RGS1
ENST00000302763CTNNA1-2013756-ENSP00000304669906 (aa)-P35221
ENST00000519768CTNNA1-218560-ENSP0000042910320 (aa)-E5RJC9
ENST00000520158CTNNA1-219719-ENSP00000429457215 (aa)-E5RIB1
ENST00000520339CTNNA1-221868-ENSP00000428202101 (aa)-E5RJL0
ENST00000524127CTNNA1-241483-ENSP0000042804994 (aa)-E5RFM3
ENST00000517904CTNNA1-205661--- (aa)--
ENST00000520400CTNNA1-222589--- (aa)--
ENST00000520520CTNNA1-223484-ENSP00000430076136 (aa)-E5RGY7
ENST00000520522CTNNA1-224390-ENSP0000042871050 (aa)-E5RGS1
ENST00000523685CTNNA1-239694-ENSP00000430240128 (aa)-E5RGD2
ENST00000518825CTNNA1-2103536-ENSP00000427821841 (aa)-G3XAM7
ENST00000523298CTNNA1-238577-ENSP00000428044110 (aa)-E5RFM5
ENST00000517980CTNNA1-206696-ENSP00000428439117 (aa)-E5RIE0
ENST00000627109CTNNA1-2443831-ENSP00000486200841 (aa)-G3XAM7
ENST00000518263CTNNA1-207548--- (aa)--
ENST00000517656CTNNA1-204554-ENSP0000043017739 (aa)-E5RGG4
ENST00000519309CTNNA1-215869-ENSP0000043067155 (aa)-E5RIT8
ENST00000521368CTNNA1-226544-ENSP0000042868622 (aa)-H0YB54
ENST00000540387CTNNA1-2432684-ENSP00000438476536 (aa)-P35221
ENST00000520865CTNNA1-225557-ENSP0000043084136 (aa)-E5RHR7
ENST00000523275CTNNA1-237536-ENSP00000429142129 (aa)-H0YBB8
ENST00000522227CTNNA1-234642-ENSP00000429636123 (aa)-E5RHV7
ENST00000521941CTNNA1-231224--- (aa)--
ENST00000518910CTNNA1-211572-ENSP00000430626161 (aa)-E5RJ41
ENST00000518381CTNNA1-208487-ENSP0000042973875 (aa)-E5RHJ5
ENST00000522792CTNNA1-2362044--- (aa)--
ENST00000518919CTNNA1-212498--- (aa)--
ENST00000522730CTNNA1-235750--- (aa)--
ENST00000523912CTNNA1-240545-ENSP00000430304156 (aa)-E5RG03
ENST00000522052CTNNA1-233579-ENSP0000048273864 (aa)-A0A087WZL6
ENST00000520260CTNNA1-220710-ENSP0000042956932 (aa)-E5RHY5
Gene Model
Click here to download ENSG00000044115's gene model file
Pathways
Pathway IDPathway NameSource
hsa04390Hippo signaling pathwayKEGG
hsa04520Adherens junctionKEGG
hsa04670Leukocyte transendothelial migrationKEGG
hsa05100Bacterial invasion of epithelial cellsKEGG
hsa05200Pathways in cancerKEGG
hsa05213Endometrial cancerKEGG
hsa05226Gastric cancerKEGG
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000044115Carotid Stenosis1.22782466839139E-617903303
ENSG00000044115Carotid Stenosis2.66929697702384E-1117903303
ENSG00000044115Blood Pressure3.30294116364036E-717903302
ENSG00000044115Blood Pressure9.61857522857645E-617903302
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000044115rs100437225138901252AGeneral risk tolerance (MTAG)30643258[0.0059-0.0107] unit decrease0.0083EFO_0008579
ENSG00000044115rs1149166565138671837TGeneral risk tolerance (MTAG)30643258[0.0079-0.0165] unit decrease0.0122EFO_0008579
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000044115's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000044115CTNNA19532.075ENSG00000035403VCL5438.614Homo_sapiens
ENSG00000044115CTNNA1100100.000ENSMUSG00000037815Ctnna110099.448Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001541ovarian follicle development-IEAProcess
GO:0001669acrosomal vesicle-IEAComponent
GO:0003723RNA binding22658674.HDAFunction
GO:0005198structural molecule activity-IEAFunction
GO:0005515protein binding12477722.15657067.16212417.17098867.17620599.18093941.19016843.20936779.22750944.23292143.24189400.24509793.25241761.25764135.26496610.28051089.IPIFunction
GO:0005794Golgi apparatus-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IDAComponent
GO:0005886plasma membrane-TASComponent
GO:0005911cell-cell junction7650039.10460003.IDAComponent
GO:0005915zonula adherens-IEAComponent
GO:0005925focal adhesion21423176.HDAComponent
GO:0007015actin filament organization-IEAProcess
GO:0007155cell adhesion8323564.NASProcess
GO:0007163establishment or maintenance of cell polarity-IEAProcess
GO:0007406negative regulation of neuroblast proliferation-IEAProcess
GO:0007568aging-IEAProcess
GO:0008013beta-catenin binding7650039.7890674.IPIFunction
GO:0008584male gonad development-IEAProcess
GO:0014704intercalated disc-IEAComponent
GO:0015629actin cytoskeleton-IEAComponent
GO:0016264gap junction assembly-IEAProcess
GO:0016342catenin complex7650039.28051089.IDAComponent
GO:0016600flotillin complex-IEAComponent
GO:0017166vinculin binding9700171.IPIFunction
GO:0030027lamellipodium-IEAComponent
GO:0030054cell junction-IDAComponent
GO:0031103axon regeneration-IEAProcess
GO:0034332adherens junction organization-TASProcess
GO:0034613cellular protein localization-IEAProcess
GO:0042475odontogenesis of dentin-containing tooth-IEAProcess
GO:0042802identical protein binding23292143.IPIFunction
GO:0043231intracellular membrane-bounded organelle-IDAComponent
GO:0043297apical junction assembly9700171.NASProcess
GO:0043627response to estrogen-IEAProcess
GO:0045295gamma-catenin binding7650039.7890674.IPIFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0045296cadherin binding7650039.12734196.IPIFunction
GO:0045880positive regulation of smoothened signaling pathway-IEAProcess
GO:0046982protein heterodimerization activity-IEAFunction
GO:0051015actin filament binding-IEAFunction
GO:0051149positive regulation of muscle cell differentiation-TASProcess
GO:0051291protein heterooligomerization-IEAProcess
GO:0071681cellular response to indole-3-methanol10868478.IDAProcess
GO:0090136epithelial cell-cell adhesion-IEAProcess
GO:2000146negative regulation of cell motility-IEAProcess
GO:2001045negative regulation of integrin-mediated signaling pathway-IEAProcess
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEAProcess
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEAProcess
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