EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26165303	Downregulation of miR-95-3p inhibits proliferation, and invasion promoting apoptosis of glioma cells by targeting CELF2.	Int J Oncol	2015 Sep	Fan B	doi: 10.3892/ijo.2015.3080
18325984	CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe.	Am J Physiol Gastrointest Liver Physiol	2008 May	Natarajan G	doi: 10.1152/ajpgi.00037.2008
15033780	CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury.	Ann N Y Acad Sci	2003 Dec	Mukhopadhyay D	-
26691217	Upregulation of cugbp2 increases response of pancreatic cancer cells to chemotherapy.	Langenbecks Arch Surg	2016 Feb	Jakstaite A	doi: 10.1007/s00423-015-1364-1

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr10	11005390	Translation_Start_Site	NA	M1?	0.16
BLCA	chr10	11325841	Missense_Mutation	NA	E421Q	0.22	RRM_1
BLCA	chr10	11165570	Silent	NA	Q46Q	0.22
BLCA	chr10	11005417	Missense_Mutation	NA	M10I	0.26
BLCA	chr10	11217474	Silent	NA	Q100Q	0.17
BLCA	chr10	11018038	Intron	novel		0.25
BLCA	chr10	11018135	Intron	novel		0.23
BLCA	chr10	11165527	Nonsense_Mutation	novel	S32*	0.22
BLCA	chr10	11321214	Silent	rs370482171	A361A	0.46
BLCA	chr10	11266656	Missense_Mutation	NA	M192I	0.14
BLCA	chr10	11266638	Missense_Mutation	novel	Q186H	0.56
BLCA	chr10	11314220	Missense_Mutation	novel	G346V	0.35
BLCA	chr10	11270683	Silent	novel	I205I	0.61
BRCA	chr10	11257865	Silent	NA	L170L	0.22
BRCA	chr10	11314198	Missense_Mutation	NA	G339R	0.56
BRCA	chr10	11165137	Intron	rs768288116		0.12
BRCA	chr10	11257846	Missense_Mutation	NA	L164P	0.16
BRCA	chr10	11275056	Splice_Site	novel	X253_splice	0.36
BRCA	chr10	11333448	3'UTR	novel		0.3
BRCA	chr10	11321310	Nonsense_Mutation	novel	Y393*	0.1
BRCA	chr10	11217466	Missense_Mutation	NA	E98Q	0.11
BRCA	chr10	11270684	Missense_Mutation	novel	V206L	0.11
BRCA	chr10	11288541	Missense_Mutation	NA	L315H	0.24
CESC	chr10	11165052	Intron	novel		0.38
CESC	chr10	11330329	3'UTR	novel		0.19
CESC	chr10	11331687	3'UTR	novel		0.53
CESC	chr10	11336334	3'UTR	novel		0.26
CESC	chr10	11333364	3'UTR	rs779495101		0.13
CESC	chr10	11266638	Silent	NA	Q186Q	0.3
CESC	chr10	11329071	3'UTR	novel		0.44
CESC	chr10	11331473	3'UTR	novel		0.21
CESC	chr10	11165194	Intron	novel		0.33
CESC	chr10	11329503	3'UTR	novel		0.09
CESC	chr10	11334037	3'UTR	novel		0.24
CESC	chr10	11333590	3'UTR	novel		0.52
CESC	chr10	11336071	3'UTR	novel		0.36
CESC	chr10	11336259	3'UTR	novel		0.12
CESC	chr10	11331859	3'UTR	novel		0.57
CESC	chr10	11330884	3'UTR	novel		0.42
CESC	chr10	11257865	Silent	NA	L170L	0.25
COAD	chr10	11329024	Missense_Mutation	NA	R500C	0.14
COAD	chr10	11329035	Silent	rs539435223	N503N	0.31
COAD	chr10	11325842	Frame_Shift_Ins	NA	*A423Gfs31**	0.4	RRM_1
COAD	chr10	11288448	Missense_Mutation	NA	A284V	0.18
COAD	chr10	11288493	Missense_Mutation	NA	S299I	0.29
COAD	chr10	11321316	Silent	rs371442396	A395A	0.33
COAD	chr10	11165622	Missense_Mutation	NA	G64R	0.36
COAD	chr10	11328983	Frame_Shift_Ins	novel	*F487Lfs69**	0.09
COAD	chr10	11165524	Missense_Mutation	NA	H31R	0.33
COAD	chr10	11266631	Missense_Mutation	novel	M184T	0.15
COAD	chr10	11314152	Silent	novel	T323T	0.15
COAD	chr10	11328983	Missense_Mutation	novel	G486D	0.06
COAD	chr10	11005419	Missense_Mutation	NA	R11I	0.36
COAD	chr10	11288448	Missense_Mutation	NA	A284V	0.19
ESCA	chr10	11257766	Silent	novel	G137G	0.33
ESCA	chr10	11288440	Silent	novel	Q281Q	0.19
ESCA	chr10	11336439	3'UTR	novel		0.36
ESCA	chr10	11325881	Missense_Mutation	novel	F434C	0.42
ESCA	chr10	11333542	3'UTR	novel		0.43
ESCA	chr10	11333542	3'UTR	novel		1
ESCA	chr10	11314224	Silent	novel	A347A	0.34
ESCA	chr10	11165576	Silent	novel	P48P	0.34
ESCA	chr10	11249190	Frame_Shift_Del	novel	*K125Sfs12**	0.4
ESCA	chr10	11330428	3'UTR	novel		0.22
ESCA	chr10	11329827	3'UTR	novel		0.19
ESCA	chr10	11333438	3'UTR	novel		0.29
GBM	chr10	11321258	Missense_Mutation	novel	T376M	0.34
GBM	chr10	11329155	3'UTR	novel		0.4
GBM	chr10	11270797	Silent	novel	L243L	0.19
GBM	chr10	11328983	Missense_Mutation	novel	G486D	0.12
HNSC	chr10	11018084	Intron	novel		0.08
HNSC	chr10	11325975	Nonsense_Mutation	novel	C465*	0.07
HNSC	chr10	11329020	Silent	novel	L498L	0.18
HNSC	chr10	11018058	Intron	novel		0.18
HNSC	chr10	11266638	Silent	NA	Q186Q	0.33
HNSC	chr10	11005424	Missense_Mutation	novel	E13K	0.22
KIRP	chr10	11266618	Missense_Mutation	novel	S180T	0.43
LGG	chr10	11321224	Missense_Mutation	novel	G365R	0.38
LGG	chr10	11321310	Silent	rs764183188	Y393Y	0.1
LIHC	chr10	11288546	Missense_Mutation	novel	S317G	0.42
LIHC	chr10	11165623	Missense_Mutation	NA	G64E	0.59
LUAD	chr10	11257783	Missense_Mutation	novel	C143F	0.47
LUAD	chr10	11329083	3'UTR	novel		0.19
LUAD	chr10	11005401	Missense_Mutation	NA	K5R	0.12
LUAD	chr10	11325887	Missense_Mutation	novel	D436G	0.15
LUAD	chr10	11005368	5'UTR	novel		0.27
LUAD	chr10	11165628	Missense_Mutation	novel	V66F	0.5
LUAD	chr10	11321220	Silent	novel	L363L	0.18
LUAD	chr10	11257824	Missense_Mutation	novel	Q157K	0.36
LUAD	chr10	11005417	Missense_Mutation	NA	M10I	0.1
LUSC	chr10	11249164	Silent	novel	P115P	0.11
LUSC	chr10	11270733	Missense_Mutation	novel	Q222R	0.39
LUSC	chr10	11249173	Missense_Mutation	novel	M118I	0.26
LUSC	chr10	11321286	Missense_Mutation	novel	Q385H	0.23
LUSC	chr10	11314172	Missense_Mutation	novel	A330E	0.19
LUSC	chr10	11257852	Missense_Mutation	novel	G166A	0.15
LUSC	chr10	11217474	Silent	NA	Q100Q	0.05
LUSC	chr10	11257742	Silent	novel	V129V	0.23
LUSC	chr10	11165561	Missense_Mutation	novel	F43L	0.23
LUSC	chr10	11321283	Silent	novel	T384T	0.4
LUSC	chr10	11165531	Missense_Mutation	novel	D33E	0.19
LUSC	chr10	11321329	Missense_Mutation	novel	T400S	0.2	RRM_1
OV	chr10	11329052	Silent	novel	*509*	0.43
OV	chr10	11321285	In_Frame_Ins	novel	Q385delinsHPV	0.08
OV	chr10	11321287	In_Frame_Ins	novel	A386delinsDHFKEKP	0.06
OV	chr10	11329052	Frame_Shift_Del	novel	*509Y	0.11
OV	chr10	11325917	Missense_Mutation	novel	F446Y	0.05
PAAD	chr10	11270694	Missense_Mutation	novel	F209S	0.2
PAAD	chr10	11321267	Missense_Mutation	novel	T379I	0.16
PRAD	chr10	11288528	Missense_Mutation	rs557804153	A311T	0.2
PRAD	chr10	11275057	Missense_Mutation	NA	L253I	0.17
PRAD	chr10	11165633	Silent	novel	Y67Y	0.37
READ	chr10	11329272	3'UTR	novel		0.38
SARC	chr10	11165245	Intron	novel		0.55
SARC	chr10	11333610	3'UTR	novel		0.5
SARC	chr10	11330217	3'UTR	novel		0.43
SARC	chr10	11332660	3'UTR	novel		0.29
SARC	chr10	11331134	3'UTR	novel		0.38
SKCM	chr10	11321319	Silent	rs750297275	A396A	0.38
SKCM	chr10	11321346	Silent	rs778526931	S405S	0.34
SKCM	chr10	11257844	Silent	NA	I163I	0.3
SKCM	chr10	11325909	Silent	NA	F443F	0.08
SKCM	chr10	11005442	Splice_Site	NA	X18_splice	0.38
STAD	chr10	11275102	Missense_Mutation	rs573495632	G268S	0.16
STAD	chr10	11165622	Missense_Mutation	NA	G64R	0.39
STAD	chr10	11018056	Intron	rs778731210		0.4
STAD	chr10	11314252	Silent	NA	L357L	0.26
STAD	chr10	11018056	Intron	rs778731210		0.18
STAD	chr10	11321354	Missense_Mutation	NA	Q408P	0.28	RRM_1
STAD	chr10	11217436	Missense_Mutation	rs577233700	V88I	0.28
STAD	chr10	11018056	Intron	rs778731210		0.38
STAD	chr10	11018125	Intron	novel		0.11
STAD	chr10	11018127	Intron	novel		0.1
STAD	chr10	11321375	Missense_Mutation	NA	S415I	0.16	RRM_1
STAD	chr10	11270702	Missense_Mutation	NA	T212A	0.26
STAD	chr10	11321322	Silent	rs374713225	A397A	0.1
STAD	chr10	11321244	Silent	novel	G371G	0.18
STAD	chr10	11288416	Splice_Site	NA	X274_splice	0.25
STAD	chr10	11325915	Frame_Shift_Del	novel	*F446Lfs17**	0.39
THCA	chr10	11257764	Missense_Mutation	NA	G137R	0.12
THYM	chr10	11330231	3'UTR	novel		0.42
UCEC	chr10	11005394	Missense_Mutation	NA	C3R	0.22
UCEC	chr10	11330323	3'UTR	novel		0.18
UCEC	chr10	11257774	Missense_Mutation	rs746403544	S140L	0.33
UCEC	chr10	11005308	5'UTR	novel		0.29
UCEC	chr10	11288448	Missense_Mutation	NA	A284V	0.33
UCEC	chr10	11314201	Missense_Mutation	novel	T340A	0.35
UCEC	chr10	11329024	Missense_Mutation	NA	R500C	0.24
UCEC	chr10	11330670	3'UTR	novel		0.29
UCEC	chr10	11334372	3'UTR	novel		0.13
UCEC	chr10	11330920	3'UTR	novel		0.48
UCEC	chr10	11333286	3'UTR	novel		0.33
UCEC	chr10	11336548	3'UTR	novel		0.1
UCEC	chr10	11165268	Intron	novel		0.13
UCEC	chr10	11334081	3'UTR	novel		0.23
UCEC	chr10	11330747	3'UTR	novel		0.56
UCEC	chr10	11330623	3'UTR	novel		0.37
UCEC	chr10	11329929	3'UTR	novel		0.26
UCEC	chr10	11321309	Missense_Mutation	NA	Y393C	0.06
UCEC	chr10	11336412	3'UTR	novel		0.4
UCEC	chr10	11005413	Missense_Mutation	NA	T9I	0.41
UCEC	chr10	11321191	Intron	NA		0.41
UCEC	chr10	11331605	3'UTR	novel		1
UCEC	chr10	11331020	3'UTR	novel		0.41
UCEC	chr10	11330612	3'UTR	novel		0.37
UCEC	chr10	11331468	3'UTR	novel		0.41
UCEC	chr10	11336392	3'UTR	novel		0.1
UCEC	chr10	11336572	3'UTR	novel		0.41
UCEC	chr10	11330078	3'UTR	novel		0.26
UCEC	chr10	11329340	3'UTR	novel		0.32
UCEC	chr10	11329768	3'UTR	novel		0.38
UCEC	chr10	11330496	3'UTR	novel		0.27
UCEC	chr10	11266621	Missense_Mutation	novel	T181A	0.17
UCEC	chr10	11275094	Missense_Mutation	NA	A265V	0.44
UCEC	chr10	11325853	Missense_Mutation	novel	L425I	0.44	RRM_1
UCEC	chr10	11329010	Missense_Mutation	novel	K495T	0.44
UCEC	chr10	11330056	3'UTR	novel		0.41
UCEC	chr10	11330427	3'UTR	novel		0.33
UCEC	chr10	11332937	3'UTR	rs751198130		0.44
UCEC	chr10	11165101	Intron	novel		0.4
UCEC	chr10	11328951	Silent	rs757315537	V475V	0.44
UCEC	chr10	11330143	3'UTR	novel		0.43
UCEC	chr10	11331806	3'UTR	novel		0.57
UCEC	chr10	11330376	3'UTR	novel		0.4
UCEC	chr10	11333834	3'UTR	novel		0.25
UCEC	chr10	11165311	Intron	novel		0.21
UCEC	chr10	11333426	3'UTR	novel		0.19
UCEC	chr10	11333627	3'UTR	novel		0.21
UCEC	chr10	11331605	3'UTR	novel		0.26
UCEC	chr10	11217498	In_Frame_Ins	novel	T108_L109insV	0.04
UCEC	chr10	11217500	Frame_Shift_Ins	novel	*L109Ffs24**	0.04
UCEC	chr10	11329258	3'UTR	novel		0.26
UCEC	chr10	11331816	3'UTR	novel		0.19
UCEC	chr10	11336495	3'UTR	novel		0.17
UCEC	chr10	11165233	Intron	novel		0.26
UCEC	chr10	11331605	3'UTR	novel		0.16
UCEC	chr10	11333286	3'UTR	novel		0.41
UCEC	chr10	11334296	3'UTR	novel		0.27
UCEC	chr10	11266599	Splice_Region	novel	G173G	0.37
UCEC	chr10	11332487	3'UTR	novel		0.32
UCEC	chr10	11335993	3'UTR	novel		0.43
UCEC	chr10	11331202	3'UTR	novel		0.36
UCEC	chr10	11331530	3'UTR	novel		0.39
UCEC	chr10	11332475	3'UTR	novel		0.44
UCEC	chr10	11334359	3'UTR	novel		0.39
UCEC	chr10	11336296	3'UTR	novel		0.3
UCEC	chr10	11334171	3'UTR	novel		0.43
UCEC	chr10	11005419	Missense_Mutation	NA	R11I	0.2
UCEC	chr10	11266604	Missense_Mutation	NA	A175V	0.06
UCEC	chr10	11329929	3'UTR	novel		0.14
UCEC	chr10	11333444	3'UTR	novel		0.17
UCEC	chr10	11334375	3'UTR	novel		0.12
UCEC	chr10	11336622	3'UTR	novel		0.12
UCEC	chr10	11331816	3'UTR	novel		0.24
UCEC	chr10	11334295	3'UTR	novel		0.13
UCEC	chr10	11333805	3'UTR	novel		0.67
UCEC	chr10	11314177	Missense_Mutation	novel	M332V	0.28
UCEC	chr10	11217484	Missense_Mutation	NA	H104Y	0.32
UCEC	chr10	11330218	3'UTR	novel		0.19
UCEC	chr10	11266628	Missense_Mutation	NA	A183V	0.56
UCEC	chr10	11333805	3'UTR	novel		0.54
UCEC	chr10	11257774	Missense_Mutation	rs746403544	S140L	0.43
UCEC	chr10	11325908	Missense_Mutation	novel	F443C	0.08
UCEC	chr10	11257793	Silent	rs555035980	N146N	0.3
UCEC	chr10	11336582	3'UTR	novel		0.36
UCEC	chr10	11331064	3'UTR	novel		0.35
UCEC	chr10	11332904	3'UTR	novel		0.4
UCEC	chr10	11333618	3'UTR	novel		0.5
UCEC	chr10	11257775	Silent	rs201641590	S140S	0.31
UCEC	chr10	11275111	Frame_Shift_Ins	novel	*M272Nfs82**	0.25
UCEC	chr10	11330744	3'UTR	novel		0.39
UCEC	chr10	11329910	3'UTR	novel		0.37
UCEC	chr10	11331873	3'UTR	novel		0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1222	0.19593
KIRC	AMP	0.0208	0.17403
PAAD	DEL	0.1467	0.169
STAD	DEL	0.1134	0.13903

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0081	Kaplan-Meier Survival Analysis
HNSC	0.00051	Kaplan-Meier Survival Analysis
ESCA	0.049	Kaplan-Meier Survival Analysis
COAD	0.013	Kaplan-Meier Survival Analysis
PAAD	0.0022	Kaplan-Meier Survival Analysis
CESC	0.016	Kaplan-Meier Survival Analysis
UCEC	0.025	Kaplan-Meier Survival Analysis
LGG	0.00022	Kaplan-Meier Survival Analysis
CHOL	0.0064	Kaplan-Meier Survival Analysis
THCA	0.014	Kaplan-Meier Survival Analysis
UVM	0.00025	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000048740 (Gene tree)
Gene ID: 10659
Gene Symbol: CELF2
Alias: Etr-3|NAPOR-2|BRUNOL3|CUGBP2
Full Name: CUGBP Elav-like family member 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 538,279 bases
Position: chr10:10,798,397-11,336,675
Accession: 2550
RBP type: canonical RBP
Summary: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000476999	RRM_1	PF00076.22	5.5e-51	1	3
ENSP00000476999	RRM_1	PF00076.22	5.5e-51	2	3
ENSP00000476999	RRM_1	PF00076.22	5.5e-51	3	3
ENSP00000382743	RRM_1	PF00076.22	5.6e-51	1	3
ENSP00000382743	RRM_1	PF00076.22	5.6e-51	2	3
ENSP00000382743	RRM_1	PF00076.22	5.6e-51	3	3
ENSP00000404834	RRM_1	PF00076.22	5.6e-51	1	3
ENSP00000404834	RRM_1	PF00076.22	5.6e-51	2	3
ENSP00000404834	RRM_1	PF00076.22	5.6e-51	3	3
ENSP00000487802	RRM_1	PF00076.22	5.6e-51	1	3
ENSP00000487802	RRM_1	PF00076.22	5.6e-51	2	3
ENSP00000487802	RRM_1	PF00076.22	5.6e-51	3	3
ENSP00000490401	RRM_1	PF00076.22	5.6e-51	1	3
ENSP00000490401	RRM_1	PF00076.22	5.6e-51	2	3
ENSP00000490401	RRM_1	PF00076.22	5.6e-51	3	3
ENSP00000346971	RRM_1	PF00076.22	6e-51	1	3
ENSP00000346971	RRM_1	PF00076.22	6e-51	2	3
ENSP00000346971	RRM_1	PF00076.22	6e-51	3	3
ENSP00000406451	RRM_1	PF00076.22	6.4e-51	1	3
ENSP00000406451	RRM_1	PF00076.22	6.4e-51	2	3
ENSP00000406451	RRM_1	PF00076.22	6.4e-51	3	3
ENSP00000488582	RRM_1	PF00076.22	6.4e-51	1	3
ENSP00000488582	RRM_1	PF00076.22	6.4e-51	2	3
ENSP00000488582	RRM_1	PF00076.22	6.4e-51	3	3
ENSP00000488268	RRM_1	PF00076.22	6.7e-51	1	3
ENSP00000488268	RRM_1	PF00076.22	6.7e-51	2	3
ENSP00000488268	RRM_1	PF00076.22	6.7e-51	3	3
ENSP00000489955	RRM_1	PF00076.22	6.8e-51	1	3
ENSP00000489955	RRM_1	PF00076.22	6.8e-51	2	3
ENSP00000489955	RRM_1	PF00076.22	6.8e-51	3	3
ENSP00000490185	RRM_1	PF00076.22	7.1e-51	1	3
ENSP00000490185	RRM_1	PF00076.22	7.1e-51	2	3
ENSP00000490185	RRM_1	PF00076.22	7.1e-51	3	3
ENSP00000443926	RRM_1	PF00076.22	7.2e-51	1	3
ENSP00000443926	RRM_1	PF00076.22	7.2e-51	2	3
ENSP00000443926	RRM_1	PF00076.22	7.2e-51	3	3
ENSP00000488690	RRM_1	PF00076.22	7.2e-51	1	3
ENSP00000488690	RRM_1	PF00076.22	7.2e-51	2	3
ENSP00000488690	RRM_1	PF00076.22	7.2e-51	3	3
ENSP00000488422	RRM_1	PF00076.22	7.7e-51	1	3
ENSP00000488422	RRM_1	PF00076.22	7.7e-51	2	3
ENSP00000488422	RRM_1	PF00076.22	7.7e-51	3	3
ENSP00000476656	RRM_1	PF00076.22	1e-38	1	3
ENSP00000476656	RRM_1	PF00076.22	1e-38	2	3
ENSP00000476656	RRM_1	PF00076.22	1e-38	3	3

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9858671	Fluorescent differential display analysis of gene expression in apoptotic neuroblastoma cells.	Gene	1998 Nov 26	Choi DK	-
10524244	Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein.	Gene	1999 Sep 3	Choi DK	-
12763013	Isolation and expression of Napor/CUG-BP2 in embryo development.	Biochem Biophys Res Commun	2003 Jun 6	Choi DK	-
22115364	Alternative splicing of the neurofibromatosis typeI pre-mRNA.	Biosci Rep	2012 Apr 1	Barron VA	doi: 10.1042/BSR20110060.
11850193	Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain.	Mech Dev	2002 Mar	Levers TE	-
11158314	The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.	Mol Cell Biol	2001 Feb	Ladd AN	-
24530415	Role of microRNA-95 in the anticancer activity of Brucein D in hepatocellular carcinoma.	Eur J Pharmacol	2014 Apr 5	Xiao Z	doi: 10.1016/j.ejphar.2014.02.002
24291840	[MicroRNA in neurodegenerative disorders].	Rinsho Shinkeigaku	2013	Sobue G	-
15226369	Multiple domains control the subcellular localization and activity of ETR-3, a regulator of nuclear and cytoplasmic RNA processing events.	J Cell Sci	2004 Jul 15	Ladd AN	-
11577082	Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor.	J Biol Chem	2001 Dec 14	Anant S	-
20622515	The role of CELF proteins in neurological disorders.	RNA Biol	2010 Jul-Aug	Gallo JM	-
28350193	Reconstitution of HuR-Inhibited CUGBP1 Expression Protects Cardiomyocytes from Acute Myocardial Infarction-Induced Injury.	Antioxid Redox Signal	2017 Nov 10	Gu L	doi: 10.1089/ars.2016.6880
24100559	Purification, crystallization and preliminary crystallographic studies of C-terminal RNA recognition motif (RRM-3) of human ELAV-type RNA-binding protein 3 (ETR-3).	Acta Crystallogr Sect F Struct Biol Cryst Commun	2013 Oct	Kashyap M	doi: 10.1107/S1744309113023439
24001600	Evaluating the effects of CELF1 deficiency in a mouse model of RNA toxicity.	Hum Mol Genet	2014 Jan 15	Kim YK	doi: 10.1093/hmg/ddt419
23795348	Reduced Expression of RNA Binding Protein CELF2, a Putative Tumor Suppressor Gene in Colon Cancer.	Immunogastroenterology	2012	Ramalingam S	-
23468433	Diversity and conservation of CELF1 and CELF2 RNA and protein expression patterns during embryonic development.	Dev Dyn	2013 Jun	Blech-Hermoni Y	doi: 10.1002/dvdy.23959
29687899	Myotonic Dystrophy and Developmental Regulation of RNA Processing.	Compr Physiol	2018 Mar 25	Thomas JD	doi: 10.1002/cphy.c170002.
16920700	ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components.	Am J Physiol Gastrointest Liver Physiol	2007 Jan	Chen Z	-
16938098	CUG-BP1/CELF1 requires UGU-rich sequences for high-affinity binding.	Biochem J	2006 Dec 1	Marquis J	-
18258790	Novel intestinal splice variants of RNA-binding protein CUGBP2: isoform-specific effects on mitotic catastrophe.	Am J Physiol Gastrointest Liver Physiol	2008 Apr	Ramalingam S	doi: 10.1152/ajpgi.00540.2007
18039683	Quantitative analysis of CUG-BP1 binding to RNA repeats.	J Biochem	2008 Mar	Mori D	-
20708014	Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death.	J Mol Cell Cardiol	2010 Nov	Zhang X	doi: 10.1016/j.yjmcc.2010.08.007
12535526	Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2.	Mol Cell	2003 Jan	Mukhopadhyay D	-
12022233	Region-specific alternative splicing in the nervous system: implications for regulation by the RNA-binding protein NAPOR.	RNA	2002 May	Zhang W	-
11414768	Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia.	Genomics	2001 Jun 15	Li D	-
10893231	A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.	J Biol Chem	2000 Sep 15	Good PJ	-
15358864	Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage.	Proc Natl Acad Sci U S A	2004 Sep 21	Murmu N	-
15033780	CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury.	Ann N Y Acad Sci	2003 Dec	Mukhopadhyay D	-
14973222	ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo.	Nucleic Acids Res	2004 Feb 18	Singh G	-
19854948	The neurofibromatosis type I pre-mRNA is a novel target of CELF protein-mediated splicing regulation.	Nucleic Acids Res	2010 Jan	Barron VA	doi: 10.1093/nar/gkp766
19720736	MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1.	Nucleic Acids Res	2009 Oct	Kino Y	doi: 10.1093/nar/gkp681
18292181	Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2.	Am J Physiol Gastrointest Liver Physiol	2008 Apr	Subramaniam D	doi: 10.1152/ajpgi.00602.2007
17725984	Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4.	Hum Mol Genet	2007 Nov 15	Chapple JP	-
17383427	Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation.	Gastroenterology	2007 Mar	Sureban SM	-
17331722	Expression of MBNL and CELF mRNA transcripts in muscles with myotonic dystrophy.	Neuromuscul Disord	2007 Apr	Nezu Y	-
21347286	RNA binding protein CUGBP2/CELF2 mediates curcumin-induced mitotic catastrophe of pancreatic cancer cells.	PLoS One	2011 Feb 11	Subramaniam D	doi: 10.1371/journal.pone.0016958.
20631008	CELF proteins regulate CFTR pre-mRNA splicing: essential role of the divergent domain of ETR-3.	Nucleic Acids Res	2010 Nov	Dujardin G	doi: 10.1093/nar/gkq573
27096301	Position-dependent activity of CELF2 in the regulation of splicing and implications for signal-responsive regulation in T cells.	RNA Biol	2016 Jun 2	Ajith S	doi: 10.1080/15476286.2016.1176663
23661609	A novel function for CUGBP2 in controlling the pro-inflammatory stimulus in H9c2 cells: subcellular trafficking of messenger molecules.	Cell Biol Int	2013 Oct	Moraes KC	doi: 10.1002/cbin.10127
27185484	Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin may alter LH release patterns by abolishing sex differences in GABA/glutamate cell number and modifying the transcriptome of the male anteroventral periventricular nucleus.	Neuroscience	2016 Aug 4	Del Pino Sans J	doi: 10.1016/j.neuroscience.2016.04.051
26443849	Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation.	Genes Dev	2015 Oct 1	Martinez NM	doi: 10.1101/gad.267245.115.
26166732	Microarray analysis of neonatal rat anteroventral periventricular transcriptomes identifies the proapoptotic Cugbp2 gene as sex-specific and regulated by estradiol.	Neuroscience	2015 Sep 10	Del Pino Sans J	doi: 10.1016/j.neuroscience.2015.07.008
29448111	In silico screening of proteins targeting circulating miRNAs for improved diagnosis of multiple myeloma.	Biochem Biophys Res Commun	2018 Mar 4	Suyal S	doi: 10.1016/j.bbrc.2018.02.103
31020708	Pleotropic role of RNA binding protein CELF2 in autophagy induction.	Mol Carcinog	2019 Aug	New J	doi: 10.1002/mc.23023
31241130	CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction.	Carcinogenesis	2019 Jun 25	Yeung YT	doi: 10.1093/carcin/bgz113
17855367	Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases.	J Biol Chem	2007 Nov 9	Xu K	-
26691217	Upregulation of cugbp2 increases response of pancreatic cancer cells to chemotherapy.	Langenbecks Arch Surg	2016 Feb	Jakstaite A	doi: 10.1007/s00423-015-1364-1
30606728	The MBNL/CELF Splicing Factors Regulate Cytosolic Sulfotransferase 4A1 Protein Expression during Cell Differentiation.	Drug Metab Dispos	2019 Mar	Idris M	doi: 10.1124/dmd.118.085290

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000542579	CELF2-205	7982	XM_017015543	ENSP00000443926	521 (aa)	XP_016871032	E9PC62
ENST00000609870	CELF2-208	1549	-	ENSP00000476392	70 (aa)	-	V9GY47
ENST00000633077	CELF2-213	1733	-	ENSP00000488690	521 (aa)	-	E9PC62
ENST00000417956	CELF2-204	8044	XM_005252357	ENSP00000404834	490 (aa)	XP_005252414	O95319
ENST00000636488	CELF2-215	3908	XM_024447775	ENSP00000489955	520 (aa)	XP_024303543	A0A1B0GU44
ENST00000633200	CELF2-214	1496	-	ENSP00000488438	94 (aa)	-	A0A0J9YXK1
ENST00000399850	CELF2-202	7085	-	ENSP00000382743	490 (aa)	-	O95319
ENST00000631816	CELF2-210	1803	XM_017015547	ENSP00000488268	514 (aa)	XP_016871036	A0A0J9YX66
ENST00000638035	CELF2-217	1849	XM_017015568	ENSP00000490401	490 (aa)	XP_016871057	O95319
ENST00000632728	CELF2-212	3827	XM_017015558	ENSP00000487802	490 (aa)	XP_016871047	O95319
ENST00000632065	CELF2-211	1952	-	ENSP00000488422	533 (aa)	-	A0A0J9YXJ0
ENST00000354897	CELF2-201	1754	-	ENSP00000346971	502 (aa)	-	Q5VZZ6
ENST00000637215	CELF2-216	2724	XM_024447772	ENSP00000490185	526 (aa)	XP_024303540	A0A1B0GUN8
ENST00000416382	CELF2-203	6894	-	ENSP00000406451	508 (aa)	-	O95319
ENST00000631460	CELF2-209	5538	-	ENSP00000488582	508 (aa)	-	O95319
ENST00000609692	CELF2-207	2210	-	ENSP00000476656	440 (aa)	-	V9GYD9
ENST00000608830	CELF2-206	1892	XM_017015569	ENSP00000476999	488 (aa)	XP_016871058	O95319

Gene Model

Click here to download ENSG00000048740's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000048740	Glomerular Filtration Rate	4.56204927790083E-5	17903292
ENSG00000048740	Glomerular Filtration Rate	5.29972326536875E-5	17903292
ENSG00000048740	Glomerular Filtration Rate	3.51876109510041E-5	17903292
ENSG00000048740	Glomerular Filtration Rate	6.74801256644168E-5	17903292
ENSG00000048740	Creatinine	9.46157803450585E-5	17903292
ENSG00000048740	Creatinine	7.49497633821469E-5	17903292
ENSG00000048740	Cystatins	5.60146183385957E-5	17903292
ENSG00000048740	E-Selectin	6.8604000E-005	19729612
ENSG00000048740	Heart Failure	2.7041388E-004	-
ENSG00000048740	Stroke	6.7929706E-004	19369658
ENSG00000048740	Stroke	7.6012746E-004	19369658
ENSG00000048740	Arteries	4.7530000E-005	-
ENSG00000048740	Platelet Function Tests	5.0685200E-005	-
ENSG00000048740	Platelet Function Tests	3.3900000E-006	-
ENSG00000048740	Platelet Function Tests	9.2200000E-007	-
ENSG00000048740	Platelet Function Tests	3.9327185E-006	-
ENSG00000048740	Platelet Function Tests	2.3870100E-005	-
ENSG00000048740	Vitamin B 12	1.3930000E-005	-
ENSG00000048740	Alzheimer Disease	2E-7	21379329
ENSG00000048740	Urine	2E-6	26631737
ENSG00000048740	Motion Sickness	1E-10	25628336
ENSG00000048740	Breast Feeding	9E-6	25475840
ENSG00000048740	Aspartate Aminotransferases	4E-7	24124411
ENSG00000048740	Alanine Transaminase	9E-6	24124411
ENSG00000048740	Thyrotropin	4E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000048740	rs1109861	10	11204306	A	Urinary albumin-to-creatinine ratio	26631737	[0.018-0.042] unit decrease	0.03	EFO_0007778
ENSG00000048740	rs10905868	10	10932293	G	Obesity-related traits	23251661	[NR] µIU/mL increase	0.02	EFO_0004748
ENSG00000048740	rs596406	10	11182702	G	Liver enzyme levels (alanine transaminase)	24124411	[0.063-0.157] unit increase	0.11	EFO_0004735
ENSG00000048740	rs596406	10	11182702	G	Liver enzyme levels (aspartate transaminase)	24124411	[0.042-0.092] unit increase	0.067	EFO_0004736
ENSG00000048740	rs2277212	10	11257772	?	Breastfeeding duration	25475840	[0.17-0.43] unit decrease	0.298	EFO_0006864
ENSG00000048740	rs10795831	10	10901416	T	Educational attainment (MTAG)	30038396	[0.0069-0.0131] unit decrease	0.01	EFO_0004784
ENSG00000048740	rs1747714	10	11119353	T	Educational attainment (MTAG)	30038396	[0.0083-0.0133] unit increase	0.0108	EFO_0004784
ENSG00000048740	rs1291817	10	11090087	A	Self-reported math ability (MTAG)	30038396	[0.0068-0.0138] unit increase	0.0103	EFO_0004875
ENSG00000048740	rs7904832	10	10870226	T	Highest math class taken (MTAG)	30038396	[0.0087-0.0169] unit decrease	0.0128	EFO_0004875
ENSG00000048740	rs1291823	10	11099301	A	Highest math class taken (MTAG)	30038396	[0.009-0.0152] unit increase	0.0121	EFO_0004875
ENSG00000048740	rs62209	10	10958376	C	Alzheimer's disease (late onset)	21379329	[1.56-2.67]	2.04	EFO_0000249
ENSG00000048740	rs10752212	10	10875158	G	Motion sickness	25628336	[0.024-0.044] unit increase	0.034	EFO_0006928
ENSG00000048740	rs4750019	10	11109917	C	Cognitive performance (MTAG)	30038396	[0.0086-0.0176] unit increase	0.0131	EFO_0008354
ENSG00000048740	rs2093623	10	10881014	A	Neuroticism	29942085	z score decrease	5.723	EFO_0007660
ENSG00000048740	rs11257029	10	11241862	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000048740	rs17148998	10	10867438	A	Educational attainment (years of education)	30038396	[0.0068-0.0134] unit increase	0.0101	EFO_0004784
ENSG00000048740	rs10795831	10	10901416	T	Educational attainment (years of education)	30038396	[0.0066-0.0132] unit decrease	0.0099	EFO_0004784
ENSG00000048740	rs1747714	10	11119353	T	Educational attainment (years of education)	30038396	[0.0079-0.0133] unit increase	0.0106	EFO_0004784
ENSG00000048740	rs11256837	10	10798572	A	Systolic blood pressure	30578418	[0.14-0.28] mmHg increase	0.2107	EFO_0006335
ENSG00000048740	rs10795831	10	10901416	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000048740	rs1291818	10	11090227	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000048740	rs36006409	10	10834980	T	Pulse pressure	30224653	[0.11-0.2] unit decrease	0.1557	EFO_0005763
ENSG00000048740	rs11256837	10	10798572	A	Pulse pressure	30578418	[0.13-0.23] mmHg increase	0.1808	EFO_0005763
ENSG00000048740	rs2093623	10	10881014	A	Neuroticism	30643256	[0.0073-0.013] unit decrease	0.010128265	EFO_0007660
ENSG00000048740	rs2093623	10	10881014	A	Depressive symptoms	30643256	[0.0046-0.0083] unit decrease	0.006458976	EFO_0007006
ENSG00000048740	rs2093623	10	10881014	A	Well-being spectrum (multivariate analysis)	30643256	[0.0045-0.0081] unit decrease	0.00633735	EFO_0007869
ENSG00000048740	rs2093623	10	10881014	A	Life satisfaction	30643256	[0.0059-0.0106] unit decrease	0.008257311	EFO_0007869
ENSG00000048740	rs2093623	10	10881014	A	Positive affect	30643256	[0.0055-0.01] unit decrease	0.007764176	EFO_0007869
ENSG00000048740	rs1291821	10	11091860	G	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.005-0.0092] unit increase	0.00710137	EFO_0006527
ENSG00000048740	rs1291821	10	11091860	G	Smoking initiation (ever regular vs never regular)	30643251	[0.0095-0.0195] unit increase	0.014492989	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000048740's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000048740	CELF2	52	39.474	ENSG00000144642	RBMS3	71	39.474
ENSG00000048740	CELF2	51	39.474	ENSG00000153250	RBMS1	60	39.474
ENSG00000048740	CELF2	51	32.787	ENSG00000131051	RBM39	73	30.000
ENSG00000048740	CELF2	98	46.488	ENSG00000140488	CELF6	100	43.564
ENSG00000048740	CELF2	50	38.158	ENSG00000076067	RBMS2	58	38.158
ENSG00000048740	CELF2	61	37.500	ENSG00000090621	PABPC4	62	37.500
ENSG00000048740	CELF2	58	41.026	ENSG00000196361	ELAVL3	76	40.741
ENSG00000048740	CELF2	50	33.333	ENSG00000179950	PUF60	61	38.462
ENSG00000048740	CELF2	60	33.784	ENSG00000101104	PABPC1L	64	34.783
ENSG00000048740	CELF2	98	45.783	ENSG00000161082	CELF5	99	43.376
ENSG00000048740	CELF2	98	43.061	ENSG00000101489	CELF4	100	61.765
ENSG00000048740	CELF2	63	43.210	ENSG00000066044	ELAVL1	81	43.210
ENSG00000048740	CELF2	56	35.443	ENSG00000116001	TIA1	83	35.443
ENSG00000048740	CELF2	59	38.272	ENSG00000162374	ELAVL4	81	38.272
ENSG00000048740	CELF2	94	83.333	ENSG00000159409	CELF3	77	83.333
ENSG00000048740	CELF2	100	80.041	ENSG00000149187	CELF1	100	88.462
ENSG00000048740	CELF2	61	34.177	ENSG00000151923	TIAL1	90	31.481
ENSG00000048740	CELF2	60	39.506	ENSG00000107105	ELAVL2	90	34.615
ENSG00000048740	CELF2	56	35.714	ENSG00000070756	PABPC1	52	34.211

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000048740	CELF2	100	81.136	ENSAPOG00000008530	-	100	79.048	Acanthochromis_polyacanthus
ENSG00000048740	CELF2	100	92.843	ENSAPOG00000017441	-	100	91.587	Acanthochromis_polyacanthus
ENSG00000048740	CELF2	100	97.541	ENSAMEG00000004946	CELF2	99	96.825	Ailuropoda_melanoleuca
ENSG00000048740	CELF2	100	79.346	ENSACIG00000019405	-	100	79.794	Amphilophus_citrinellus
ENSG00000048740	CELF2	100	85.540	ENSACIG00000004318	-	100	86.242	Amphilophus_citrinellus
ENSG00000048740	CELF2	100	81.136	ENSAOCG00000022110	-	100	79.048	Amphiprion_ocellaris
ENSG00000048740	CELF2	70	90.778	ENSAOCG00000022420	-	80	90.286	Amphiprion_ocellaris
ENSG00000048740	CELF2	89	91.935	ENSAOCG00000024314	-	97	82.353	Amphiprion_ocellaris
ENSG00000048740	CELF2	100	81.136	ENSAPEG00000003362	-	100	79.048	Amphiprion_percula
ENSG00000048740	CELF2	100	84.867	ENSAPEG00000017360	-	100	85.567	Amphiprion_percula
ENSG00000048740	CELF2	100	82.150	ENSATEG00000017169	-	100	80.190	Anabas_testudineus
ENSG00000048740	CELF2	100	92.843	ENSATEG00000021942	-	100	92.843	Anabas_testudineus
ENSG00000048740	CELF2	100	98.361	ENSAPLG00000010064	CELF2	97	98.986	Anas_platyrhynchos
ENSG00000048740	CELF2	97	97.722	ENSACAG00000007661	CELF2	100	98.721	Anolis_carolinensis
ENSG00000048740	CELF2	100	100.000	ENSANAG00000024646	CELF2	100	100.000	Aotus_nancymaae
ENSG00000048740	CELF2	100	81.174	ENSACLG00000003085	-	100	79.848	Astatotilapia_calliptera
ENSG00000048740	CELF2	100	92.638	ENSACLG00000013768	-	100	93.402	Astatotilapia_calliptera
ENSG00000048740	CELF2	100	92.025	ENSAMXG00000005933	celf2	95	91.532	Astyanax_mexicanus
ENSG00000048740	CELF2	100	99.803	ENSBTAG00000008937	CELF2	100	99.803	Bos_taurus
ENSG00000048740	CELF2	100	100.000	ENSCJAG00000020663	CELF2	100	100.000	Callithrix_jacchus
ENSG00000048740	CELF2	100	99.795	ENSCAFG00000004973	CELF2	100	99.795	Canis_familiaris
ENSG00000048740	CELF2	100	98.975	ENSCAFG00020005823	CELF2	100	98.656	Canis_lupus_dingo
ENSG00000048740	CELF2	100	99.808	ENSCHIG00000015379	CELF2	100	99.808	Capra_hircus
ENSG00000048740	CELF2	97	100.000	ENSTSYG00000005118	CELF2	88	100.000	Carlito_syrichta
ENSG00000048740	CELF2	100	81.352	ENSTSYG00000025428	-	97	82.041	Carlito_syrichta
ENSG00000048740	CELF2	100	85.556	ENSCAPG00000014106	CELF2	96	85.556	Cavia_aperea
ENSG00000048740	CELF2	100	100.000	ENSCPOG00000012567	CELF2	100	100.000	Cavia_porcellus
ENSG00000048740	CELF2	100	100.000	ENSCCAG00000020159	CELF2	100	100.000	Cebus_capucinus
ENSG00000048740	CELF2	100	100.000	ENSCATG00000032144	CELF2	100	100.000	Cercocebus_atys
ENSG00000048740	CELF2	100	100.000	ENSCLAG00000010311	CELF2	100	100.000	Chinchilla_lanigera
ENSG00000048740	CELF2	100	100.000	ENSCSAG00000013405	CELF2	100	99.808	Chlorocebus_sabaeus
ENSG00000048740	CELF2	97	83.333	ENSCHOG00000002945	CELF2	100	83.333	Choloepus_hoffmanni
ENSG00000048740	CELF2	100	99.213	ENSCPBG00000027840	CELF2	100	96.970	Chrysemys_picta_bellii
ENSG00000048740	CELF2	100	100.000	ENSCANG00000033443	CELF2	100	100.000	Colobus_angolensis_palliatus
ENSG00000048740	CELF2	100	99.803	ENSCGRG00001015058	Celf2	100	98.462	Cricetulus_griseus_chok1gshd
ENSG00000048740	CELF2	100	99.803	ENSCGRG00000011178	Celf2	100	99.773	Cricetulus_griseus_crigri
ENSG00000048740	CELF2	100	92.025	ENSCSEG00000003342	-	100	92.784	Cynoglossus_semilaevis
ENSG00000048740	CELF2	84	86.441	ENSCSEG00000015335	-	100	73.608	Cynoglossus_semilaevis
ENSG00000048740	CELF2	100	93.047	ENSCVAG00000004383	-	100	91.205	Cyprinodon_variegatus
ENSG00000048740	CELF2	100	81.059	ENSCVAG00000009088	-	100	79.048	Cyprinodon_variegatus
ENSG00000048740	CELF2	100	92.025	ENSDARG00000002131	celf2	99	92.025	Danio_rerio
ENSG00000048740	CELF2	84	96.610	ENSDARG00000114049	CABZ01018956.1	63	83.333	Danio_rerio
ENSG00000048740	CELF2	100	99.795	ENSDNOG00000000252	CELF2	100	99.793	Dasypus_novemcinctus
ENSG00000048740	CELF2	100	100.000	ENSDORG00000006455	Celf2	100	100.000	Dipodomys_ordii
ENSG00000048740	CELF2	84	100.000	ENSETEG00000008414	CELF2	100	75.591	Echinops_telfairi
ENSG00000048740	CELF2	100	64.777	ENSEBUG00000014743	-	100	65.314	Eptatretus_burgeri
ENSG00000048740	CELF2	98	60.251	ENSEBUG00000007835	-	93	60.000	Eptatretus_burgeri
ENSG00000048740	CELF2	100	69.293	ENSEBUG00000002471	-	86	66.857	Eptatretus_burgeri
ENSG00000048740	CELF2	97	51.646	ENSEBUG00000008128	-	93	50.460	Eptatretus_burgeri
ENSG00000048740	CELF2	100	99.808	ENSEASG00005019262	CELF2	100	99.808	Equus_asinus_asinus
ENSG00000048740	CELF2	100	99.808	ENSECAG00000006649	CELF2	100	99.808	Equus_caballus
ENSG00000048740	CELF2	100	89.634	ENSEEUG00000005658	CELF2	100	88.956	Erinaceus_europaeus
ENSG00000048740	CELF2	100	78.296	ENSELUG00000008279	-	100	77.127	Esox_lucius
ENSG00000048740	CELF2	100	90.381	ENSELUG00000005848	-	100	90.381	Esox_lucius
ENSG00000048740	CELF2	100	99.611	ENSFCAG00000004738	CELF2	100	99.611	Felis_catus
ENSG00000048740	CELF2	100	98.361	ENSFALG00000001873	CELF2	96	98.986	Ficedula_albicollis
ENSG00000048740	CELF2	100	100.000	ENSFDAG00000015074	CELF2	100	100.000	Fukomys_damarensis
ENSG00000048740	CELF2	100	92.638	ENSFHEG00000010537	-	100	90.631	Fundulus_heteroclitus
ENSG00000048740	CELF2	100	80.488	ENSFHEG00000007136	-	97	79.070	Fundulus_heteroclitus
ENSG00000048740	CELF2	77	94.444	ENSGMOG00000008983	-	63	67.949	Gadus_morhua
ENSG00000048740	CELF2	100	74.291	ENSGMOG00000010163	-	96	73.410	Gadus_morhua
ENSG00000048740	CELF2	100	99.222	ENSGALG00000034590	CELF2	100	99.174	Gallus_gallus
ENSG00000048740	CELF2	100	92.434	ENSGAFG00000004951	-	100	93.196	Gambusia_affinis
ENSG00000048740	CELF2	100	81.947	ENSGAFG00000015151	-	100	80.000	Gambusia_affinis
ENSG00000048740	CELF2	100	98.361	ENSGAGG00000023497	CELF2	100	98.269	Gopherus_agassizii
ENSG00000048740	CELF2	100	100.000	ENSGGOG00000009330	CELF2	100	100.000	Gorilla_gorilla
ENSG00000048740	CELF2	100	92.638	ENSHBUG00000005058	-	100	91.587	Haplochromis_burtoni
ENSG00000048740	CELF2	100	74.949	ENSHBUG00000005718	-	100	75.876	Haplochromis_burtoni
ENSG00000048740	CELF2	100	100.000	ENSHGLG00000017139	CELF2	100	100.000	Heterocephalus_glaber_female
ENSG00000048740	CELF2	100	100.000	ENSHGLG00100010282	CELF2	100	100.000	Heterocephalus_glaber_male
ENSG00000048740	CELF2	100	80.982	ENSHCOG00000005953	-	100	81.237	Hippocampus_comes
ENSG00000048740	CELF2	100	79.550	ENSHCOG00000011353	-	98	78.656	Hippocampus_comes
ENSG00000048740	CELF2	100	88.270	ENSIPUG00000008622	celf2	100	88.270	Ictalurus_punctatus
ENSG00000048740	CELF2	100	100.000	ENSSTOG00000001564	CELF2	100	100.000	Ictidomys_tridecemlineatus
ENSG00000048740	CELF2	100	99.803	ENSJJAG00000011472	Celf2	100	99.796	Jaculus_jaculus
ENSG00000048740	CELF2	99	82.609	ENSKMAG00000004057	-	84	73.684	Kryptolebias_marmoratus
ENSG00000048740	CELF2	100	86.912	ENSKMAG00000014795	-	100	87.629	Kryptolebias_marmoratus
ENSG00000048740	CELF2	87	93.443	ENSLBEG00000025125	-	76	86.239	Labrus_bergylta
ENSG00000048740	CELF2	100	79.878	ENSLBEG00000010618	-	100	77.567	Labrus_bergylta
ENSG00000048740	CELF2	100	97.131	ENSLACG00000009779	CELF2	99	95.202	Latimeria_chalumnae
ENSG00000048740	CELF2	100	96.721	ENSLOCG00000015690	celf2	100	94.084	Lepisosteus_oculatus
ENSG00000048740	CELF2	100	99.803	ENSLAFG00000013612	CELF2	97	99.803	Loxodonta_africana
ENSG00000048740	CELF2	100	100.000	ENSMFAG00000033084	CELF2	100	100.000	Macaca_fascicularis
ENSG00000048740	CELF2	100	100.000	ENSMMUG00000037449	CELF2	100	99.812	Macaca_mulatta
ENSG00000048740	CELF2	100	96.614	ENSMNEG00000045450	CELF2	100	96.136	Macaca_nemestrina
ENSG00000048740	CELF2	100	100.000	ENSMLEG00000040420	CELF2	100	100.000	Mandrillus_leucophaeus
ENSG00000048740	CELF2	100	92.843	ENSMAMG00000017876	-	100	93.608	Mastacembelus_armatus
ENSG00000048740	CELF2	100	81.911	ENSMAMG00000023208	-	100	82.041	Mastacembelus_armatus
ENSG00000048740	CELF2	100	81.174	ENSMZEG00005006950	-	100	79.848	Maylandia_zebra
ENSG00000048740	CELF2	100	93.047	ENSMZEG00005021669	-	100	90.667	Maylandia_zebra
ENSG00000048740	CELF2	100	98.361	ENSMGAG00000004551	CELF2	100	98.361	Meleagris_gallopavo
ENSG00000048740	CELF2	97	93.735	ENSMAUG00000009783	Celf2	91	94.614	Mesocricetus_auratus
ENSG00000048740	CELF2	100	88.571	ENSMAUG00000014367	-	85	100.000	Mesocricetus_auratus
ENSG00000048740	CELF2	100	100.000	ENSMICG00000007867	CELF2	100	100.000	Microcebus_murinus
ENSG00000048740	CELF2	100	100.000	ENSMOCG00000004765	Celf2	100	100.000	Microtus_ochrogaster
ENSG00000048740	CELF2	100	93.047	ENSMMOG00000006702	-	100	93.814	Mola_mola
ENSG00000048740	CELF2	100	71.485	ENSMMOG00000012104	-	100	73.347	Mola_mola
ENSG00000048740	CELF2	97	99.504	ENSMODG00000016763	CELF2	100	99.504	Monodelphis_domestica
ENSG00000048740	CELF2	100	92.638	ENSMALG00000000961	-	100	93.402	Monopterus_albus
ENSG00000048740	CELF2	100	81.504	ENSMALG00000011132	-	100	79.810	Monopterus_albus
ENSG00000048740	CELF2	100	99.803	MGP_CAROLIEiJ_G0023161	Celf2	100	100.000	Mus_caroli
ENSG00000048740	CELF2	100	99.803	ENSMUSG00000002107	Celf2	100	100.000	Mus_musculus
ENSG00000048740	CELF2	100	99.803	MGP_PahariEiJ_G0019221	Celf2	100	100.000	Mus_pahari
ENSG00000048740	CELF2	100	99.803	MGP_SPRETEiJ_G0024079	Celf2	100	100.000	Mus_spretus
ENSG00000048740	CELF2	100	99.803	ENSMPUG00000016406	CELF2	100	99.803	Mustela_putorius_furo
ENSG00000048740	CELF2	100	98.770	ENSMLUG00000005791	CELF2	99	98.016	Myotis_lucifugus
ENSG00000048740	CELF2	100	94.488	ENSNGAG00000021158	Celf2	100	93.462	Nannospalax_galili
ENSG00000048740	CELF2	100	81.136	ENSNBRG00000000322	-	100	79.810	Neolamprologus_brichardi
ENSG00000048740	CELF2	100	92.638	ENSNBRG00000012818	-	100	93.402	Neolamprologus_brichardi
ENSG00000048740	CELF2	100	100.000	ENSNLEG00000011968	CELF2	100	100.000	Nomascus_leucogenys
ENSG00000048740	CELF2	100	87.174	ENSMEUG00000015276	CELF2	100	87.205	Notamacropus_eugenii
ENSG00000048740	CELF2	100	98.606	ENSOPRG00000011502	CELF2	100	98.622	Ochotona_princeps
ENSG00000048740	CELF2	100	100.000	ENSODEG00000000887	CELF2	100	100.000	Octodon_degus
ENSG00000048740	CELF2	100	93.047	ENSONIG00000017931	-	100	90.667	Oreochromis_niloticus
ENSG00000048740	CELF2	100	81.339	ENSONIG00000008624	-	100	79.619	Oreochromis_niloticus
ENSG00000048740	CELF2	97	78.404	ENSOANG00000015432	-	100	78.404	Ornithorhynchus_anatinus
ENSG00000048740	CELF2	100	100.000	ENSOCUG00000004961	CELF2	97	100.000	Oryctolagus_cuniculus
ENSG00000048740	CELF2	100	93.252	ENSORLG00000017111	-	100	91.205	Oryzias_latipes
ENSG00000048740	CELF2	100	81.377	ENSORLG00000003894	-	100	79.658	Oryzias_latipes
ENSG00000048740	CELF2	100	93.252	ENSORLG00020006562	-	100	93.252	Oryzias_latipes_hni
ENSG00000048740	CELF2	100	81.377	ENSORLG00020015261	-	100	79.507	Oryzias_latipes_hni
ENSG00000048740	CELF2	100	93.252	ENSORLG00015006221	-	100	91.205	Oryzias_latipes_hsok
ENSG00000048740	CELF2	100	81.377	ENSORLG00015008084	-	100	79.658	Oryzias_latipes_hsok
ENSG00000048740	CELF2	100	93.456	ENSOMEG00000023599	-	100	91.205	Oryzias_melastigma
ENSG00000048740	CELF2	100	81.947	ENSOMEG00000000277	-	100	80.190	Oryzias_melastigma
ENSG00000048740	CELF2	97	98.753	ENSOGAG00000005541	CELF2	100	99.748	Otolemur_garnettii
ENSG00000048740	CELF2	97	96.278	ENSOARG00000014052	CELF2	100	96.278	Ovis_aries
ENSG00000048740	CELF2	100	100.000	ENSPPAG00000029170	CELF2	100	100.000	Pan_paniscus
ENSG00000048740	CELF2	100	99.611	ENSPPRG00000021517	CELF2	100	99.611	Panthera_pardus
ENSG00000048740	CELF2	97	89.616	ENSPTIG00000019418	CELF2	87	88.488	Panthera_tigris_altaica
ENSG00000048740	CELF2	100	100.000	ENSPTRG00000002284	CELF2	100	100.000	Pan_troglodytes
ENSG00000048740	CELF2	100	100.000	ENSPANG00000023401	CELF2	100	100.000	Papio_anubis
ENSG00000048740	CELF2	100	81.264	ENSPKIG00000025513	-	93	82.432	Paramormyrops_kingsleyae
ENSG00000048740	CELF2	100	93.047	ENSPKIG00000025033	-	100	90.667	Paramormyrops_kingsleyae
ENSG00000048740	CELF2	100	98.975	ENSPSIG00000013861	CELF2	100	96.929	Pelodiscus_sinensis
ENSG00000048740	CELF2	100	74.898	ENSPMGG00000005719	-	100	75.826	Periophthalmus_magnuspinnatus
ENSG00000048740	CELF2	100	89.571	ENSPMGG00000014571	-	97	89.879	Periophthalmus_magnuspinnatus
ENSG00000048740	CELF2	100	100.000	ENSPEMG00000017244	Celf2	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000048740	CELF2	90	56.086	ENSPMAG00000006638	-	99	56.563	Petromyzon_marinus
ENSG00000048740	CELF2	89	66.154	ENSPMAG00000002591	-	88	71.121	Petromyzon_marinus
ENSG00000048740	CELF2	63	98.089	ENSPCIG00000003025	CELF2	100	98.089	Phascolarctos_cinereus
ENSG00000048740	CELF2	100	82.556	ENSPFOG00000013076	-	100	80.571	Poecilia_formosa
ENSG00000048740	CELF2	97	82.875	ENSPFOG00000012840	-	100	83.940	Poecilia_formosa
ENSG00000048740	CELF2	99	86.957	ENSPLAG00000014643	-	76	78.022	Poecilia_latipinna
ENSG00000048740	CELF2	100	81.224	ENSPLAG00000020446	-	97	84.635	Poecilia_latipinna
ENSG00000048740	CELF2	100	81.707	ENSPLAG00000021601	-	100	80.247	Poecilia_latipinna
ENSG00000048740	CELF2	100	92.843	ENSPMEG00000013036	-	100	92.843	Poecilia_mexicana
ENSG00000048740	CELF2	100	82.389	ENSPMEG00000007082	-	100	80.418	Poecilia_mexicana
ENSG00000048740	CELF2	100	92.638	ENSPREG00000018002	-	100	92.638	Poecilia_reticulata
ENSG00000048740	CELF2	100	81.744	ENSPREG00000007795	-	100	79.810	Poecilia_reticulata
ENSG00000048740	CELF2	100	100.000	ENSPPYG00000002083	CELF2	100	100.000	Pongo_abelii
ENSG00000048740	CELF2	100	92.032	ENSPCAG00000010882	CELF2	100	91.923	Procavia_capensis
ENSG00000048740	CELF2	100	91.363	ENSPCOG00000026161	CELF2	100	91.363	Propithecus_coquereli
ENSG00000048740	CELF2	91	100.000	ENSPVAG00000003294	CELF2	75	100.000	Pteropus_vampyrus
ENSG00000048740	CELF2	100	81.136	ENSPNYG00000002565	-	100	79.810	Pundamilia_nyererei
ENSG00000048740	CELF2	100	86.503	ENSPNYG00000015832	-	100	85.086	Pundamilia_nyererei
ENSG00000048740	CELF2	100	92.025	ENSPNAG00000006639	celf2	100	92.025	Pygocentrus_nattereri
ENSG00000048740	CELF2	100	98.975	ENSRNOG00000023661	Celf2	100	98.464	Rattus_norvegicus
ENSG00000048740	CELF2	100	100.000	ENSRBIG00000042443	CELF2	100	100.000	Rhinopithecus_bieti
ENSG00000048740	CELF2	100	97.551	ENSRROG00000044478	CELF2	100	97.148	Rhinopithecus_roxellana
ENSG00000048740	CELF2	100	100.000	ENSSBOG00000028844	CELF2	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000048740	CELF2	100	82.822	ENSSFOG00015023817	-	100	82.822	Scleropages_formosus
ENSG00000048740	CELF2	100	89.775	ENSSFOG00015023981	-	100	89.293	Scleropages_formosus
ENSG00000048740	CELF2	100	93.252	ENSSMAG00000008925	-	100	90.722	Scophthalmus_maximus
ENSG00000048740	CELF2	100	79.184	ENSSMAG00000008985	-	100	80.000	Scophthalmus_maximus
ENSG00000048740	CELF2	100	92.843	ENSSDUG00000015603	-	100	93.608	Seriola_dumerili
ENSG00000048740	CELF2	100	81.911	ENSSDUG00000022515	-	100	80.153	Seriola_dumerili
ENSG00000048740	CELF2	100	81.911	ENSSLDG00000010918	-	100	80.153	Seriola_lalandi_dorsalis
ENSG00000048740	CELF2	100	91.207	ENSSLDG00000001157	-	100	91.959	Seriola_lalandi_dorsalis
ENSG00000048740	CELF2	100	92.828	ENSSPUG00000018833	CELF2	100	93.595	Sphenodon_punctatus
ENSG00000048740	CELF2	100	81.744	ENSSPAG00000005647	-	100	79.619	Stegastes_partitus
ENSG00000048740	CELF2	96	92.111	ENSSPAG00000007458	-	99	90.289	Stegastes_partitus
ENSG00000048740	CELF2	100	99.616	ENSSSCG00000011121	-	100	99.616	Sus_scrofa
ENSG00000048740	CELF2	100	98.975	ENSTGUG00000002136	CELF2	100	98.381	Taeniopygia_guttata
ENSG00000048740	CELF2	100	93.252	ENSTRUG00000010147	-	100	90.667	Takifugu_rubripes
ENSG00000048740	CELF2	100	79.960	ENSTRUG00000016905	-	100	77.947	Takifugu_rubripes
ENSG00000048740	CELF2	100	80.527	ENSTNIG00000016009	-	99	80.527	Tetraodon_nigroviridis
ENSG00000048740	CELF2	100	88.957	ENSTNIG00000007201	-	99	88.306	Tetraodon_nigroviridis
ENSG00000048740	CELF2	100	98.008	ENSTBEG00000007939	CELF2	100	97.835	Tupaia_belangeri
ENSG00000048740	CELF2	100	90.637	ENSTTRG00000014665	CELF2	100	90.748	Tursiops_truncatus
ENSG00000048740	CELF2	61	99.666	ENSUAMG00000008810	CELF2	100	99.666	Ursus_americanus
ENSG00000048740	CELF2	93	96.923	ENSUAMG00000002661	-	92	96.923	Ursus_americanus
ENSG00000048740	CELF2	100	92.683	ENSUMAG00000012780	CELF2	99	90.945	Ursus_maritimus
ENSG00000048740	CELF2	97	89.367	ENSVPAG00000009360	CELF2	100	89.367	Vicugna_pacos
ENSG00000048740	CELF2	100	99.805	ENSVVUG00000006430	CELF2	100	99.805	Vulpes_vulpes
ENSG00000048740	CELF2	100	97.773	ENSXETG00000021992	celf2	100	97.694	Xenopus_tropicalis
ENSG00000048740	CELF2	100	82.209	ENSXCOG00000011871	-	99	81.727	Xiphophorus_couchianus
ENSG00000048740	CELF2	89	80.645	ENSXCOG00000020811	-	75	80.583	Xiphophorus_couchianus
ENSG00000048740	CELF2	100	92.638	ENSXMAG00000024223	-	100	91.013	Xiphophorus_maculatus
ENSG00000048740	CELF2	100	81.707	ENSXMAG00000016859	-	100	79.619	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11158314.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006376	mRNA splice site selection	21873635.	IBA	Process
GO:0006376	mRNA splice site selection	11158314.	IDA	Process
GO:0006396	RNA processing	9887331.	TAS	Process
GO:0008016	regulation of heart contraction	9887331.	TAS	Process
GO:0036002	pre-mRNA binding	11158314.	IDA	Function
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

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Expression

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GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.