EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr7	74235601	Silent	novel	I295I	0.33
BLCA	chr7	74249112	Missense_Mutation	novel	P78S	0.78
BLCA	chr7	74249085	Missense_Mutation	novel	L87V	0.21
BLCA	chr7	74232132	Nonsense_Mutation	novel	K347*	0.39
BLCA	chr7	74252436	Missense_Mutation	novel	R59T	0.22
BLCA	chr7	74232156	Missense_Mutation	novel	G339S	0.25
BRCA	chr7	74254355	Missense_Mutation	novel	A10V	0.67
CESC	chr7	74232120	Missense_Mutation	NA	P351A	0.12
CESC	chr7	74238960	Nonsense_Mutation	novel	S241*	0.21
CESC	chr7	74243201	Silent	novel	I160I	0.18
CESC	chr7	74232089	3'UTR	novel		0.09
CESC	chr7	74238932	Silent	rs782013788	N250N	0.26
CESC	chr7	74246746	Missense_Mutation	novel	R117M	0.41
CHOL	chr7	74246734	Missense_Mutation	novel	K121T	0.52
COAD	chr7	74240048	Missense_Mutation	novel	D195N	0.34
COAD	chr7	74240012	Missense_Mutation	rs548294232	E207K	0.09
COAD	chr7	74254346	Missense_Mutation	novel	V13A	0.46
COAD	chr7	74232136	Nonsense_Mutation	novel	C345*	0.11
GBM	chr7	74243180	Silent	rs782042572	F167F	0.22
GBM	chr7	74240012	Missense_Mutation	rs548294232	E207K	0.53
GBM	chr7	74240075	Missense_Mutation	novel	A186T	0.07
GBM	chr7	74249013	Splice_Region	novel	R111R	0.18
GBM	chr7	74232075	3'UTR	novel		0.27
GBM	chr7	74237379	Missense_Mutation	novel	I275L	0.18
GBM	chr7	74232114	Missense_Mutation	novel	A353T	0.05
HNSC	chr7	74249057	Missense_Mutation	novel	P96L	0.19
HNSC	chr7	74235642	Missense_Mutation	novel	L282F	0.36
HNSC	chr7	74232174	Missense_Mutation	novel	S333A	0.25
KIRC	chr7	74246724	Silent	NA	A124A	0.37
KIRC	chr7	74240020	Missense_Mutation	novel	N204S	0.25
LIHC	chr7	74239967	Missense_Mutation	novel	I222V	0.37
LIHC	chr7	74243204	Missense_Mutation	novel	E159D	0.49
LIHC	chr7	74249106	Missense_Mutation	novel	T80S	0.28
LUAD	chr7	74232025	3'UTR	novel		0.35
LUAD	chr7	74246747	Missense_Mutation	novel	R117G	0.18
LUAD	chr7	74249756	Missense_Mutation	NA	P70A	0.17
LUAD	chr7	74254341	Missense_Mutation	NA	A15S	0.41
LUAD	chr7	74254363	Silent	NA	C7C	0.3
LUAD	chr7	74235631	Missense_Mutation	NA	L285F	0.39
LUSC	chr7	74238937	Missense_Mutation	novel	E249Q	0.27
LUSC	chr7	74238937	Missense_Mutation	novel	E249Q	0.24
OV	chr7	74237371	Missense_Mutation	novel	E277D	0.04
OV	chr7	74235609	Frame_Shift_Del	novel	*E293Kfs20**	0.1
PAAD	chr7	74249740	Missense_Mutation	novel	A75V	0.05
SARC	chr7	74239941	Silent	novel	R230R	0.21
SKCM	chr7	74232120	Missense_Mutation	NA	P351S	0.48
SKCM	chr7	74238969	Missense_Mutation	NA	S238F	0.22
SKCM	chr7	74231977	3'UTR	novel		0.36
SKCM	chr7	74232094	3'UTR	novel		0.11
SKCM	chr7	74254286	Missense_Mutation	novel	H33L	0.14
SKCM	chr7	74254400	5'UTR	novel		0.3
SKCM	chr7	74232119	Missense_Mutation	rs139636296	P351L	0.25
SKCM	chr7	74232120	Missense_Mutation	NA	P351S	0.25
STAD	chr7	74232188	Missense_Mutation	rs41272921	A328V	0.24
STAD	chr7	74235529	Splice_Region	rs369383698		0.39
STAD	chr7	74240012	Missense_Mutation	rs548294232	E207K	0.27
STAD	chr7	74232123	Missense_Mutation	novel	A350T	0.05
STAD	chr7	74232187	Silent	rs377161147	A328A	0.21
UCEC	chr7	74232074	3'UTR	novel		0.32
UCEC	chr7	74239976	Nonsense_Mutation	NA	E219*	0.14
UCEC	chr7	74243179	Missense_Mutation	NA	A168T	0.24
UCEC	chr7	74237373	Missense_Mutation	rs781977542	E277K	0.14
UCEC	chr7	74240052	Silent	NA	L193L	0.14
UCEC	chr7	74243217	Missense_Mutation	NA	R155M	0.49
UCEC	chr7	74249027	Missense_Mutation	rs781895699	N106S	0.4
UCEC	chr7	74243160	Missense_Mutation	novel	S174L	0.17
UCEC	chr7	74243145	Splice_Site	novel	X179_splice	0.34
UCEC	chr7	74240065	Missense_Mutation	novel	R189Q	0.35
UCEC	chr7	74243239	Missense_Mutation	novel	D148N	0.41
UCEC	chr7	74252443	Missense_Mutation	NA	V57M	0.32
UCEC	chr7	74231969	3'UTR	novel		0.29
UCEC	chr7	74246740	Missense_Mutation	rs148234405	K119T	0.14
UCEC	chr7	74232217	Splice_Site	novel	X319_splice	0.38
UCEC	chr7	74235638	Missense_Mutation	rs782546413	A283V	0.13
UCEC	chr7	74239958	Missense_Mutation	novel	A225T	0.34
UCEC	chr7	74237421	Missense_Mutation	novel	L261M	0.47
UCEC	chr7	74231969	3'UTR	novel		0.57
UCEC	chr7	74249085	Missense_Mutation	novel	L87M	0.2
UCEC	chr7	74235610	Silent	novel	P292P	0.41
UCEC	chr7	74232188	Missense_Mutation	rs41272921	A328V	0.09
UCEC	chr7	74246695	Missense_Mutation	rs782112033	R134Q	0.43
UCEC	chr7	74254401	5'UTR	novel		0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.2708	0.13215
TGCT	AMP	0.7067	0.035574
THCA	DEL	0.002	0.27619

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0012	Kaplan-Meier Survival Analysis
MESO	0.00019	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
UCS	0.017	Kaplan-Meier Survival Analysis
LUSC	0.036	Kaplan-Meier Survival Analysis
KIRP	0.047	Kaplan-Meier Survival Analysis
CESC	0.01	Kaplan-Meier Survival Analysis
LAML	0.022	Kaplan-Meier Survival Analysis
KICH	0.011	Kaplan-Meier Survival Analysis
UCEC	0.011	Kaplan-Meier Survival Analysis
GBM	0.0035	Kaplan-Meier Survival Analysis
LIHC	0.00047	Kaplan-Meier Survival Analysis
DLBC	0.025	Kaplan-Meier Survival Analysis
THCA	0.027	Kaplan-Meier Survival Analysis
LUAD	0.0012	Kaplan-Meier Survival Analysis
UVM	0.0001	Kaplan-Meier Survival Analysis
OV	0.0066	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000049541 (Gene tree)
Gene ID: 5982
Gene Symbol: RFC2
Alias: A1|RFC40
Full Name: replication factor C subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 22,974 bases
Position: chr7:74,231,485-74,254,458
Accession: 9970
RBP type: non-canonical RBP
Summary: This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8812460	Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.	Genomics	1996 Sep 1	Osborne LR	-
19144639	Structural basis of the influenza A virus RNA polymerase PB2 RNA-binding domain containing the pathogenicity-determinant lysine 627 residue.	J Biol Chem	2009 Mar 13	Kuzuhara T	doi: 10.1074/jbc.C800224200

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000485545	RFC2-208	847	-	ENSP00000419320	120 (aa)	-	H7C596
ENST00000055077	RFC2-201	1695	-	ENSP00000055077	354 (aa)	-	P35250
ENST00000463194	RFC2-203	853	-	ENSP00000419827	101 (aa)	-	H7C5G4
ENST00000497430	RFC2-212	753	-	ENSP00000420404	198 (aa)	-	H7C5P4
ENST00000479105	RFC2-206	957	-	ENSP00000420392	52 (aa)	-	H7C5P1
ENST00000480432	RFC2-207	871	-	ENSP00000418899	77 (aa)	-	F8WC37
ENST00000352131	RFC2-202	1576	-	ENSP00000275627	320 (aa)	-	P35250
ENST00000470266	RFC2-204	881	-	ENSP00000420513	75 (aa)	-	H7C5Q7
ENST00000621097	RFC2-213	1635	XM_006716080	ENSP00000479768	251 (aa)	XP_006716143	A0A087WVY3
ENST00000473493	RFC2-205	304	-	-	- (aa)	-	-
ENST00000493156	RFC2-210	782	-	ENSP00000420563	37 (aa)	-	F8WDC9
ENST00000494019	RFC2-211	730	-	ENSP00000419341	87 (aa)	-	H7C5A0
ENST00000491206	RFC2-209	726	-	ENSP00000420731	28 (aa)	-	H7C5S7

Gene Model

Click here to download ENSG00000049541's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG
hsa03420	Nucleotide excision repair	KEGG
hsa03430	Mismatch repair	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000049541's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000049541	RFC2	98	96.356	ENSMUSG00000023104	Rfc2	100	91.243	Mus_musculus
ENSG00000049541	RFC2	94	61.506	YOL094C		96	61.218	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003689	DNA clamp loader activity	21873635.	IBA	Function
GO:0003689	DNA clamp loader activity	12930902.	IDA	Function
GO:0005515	protein binding	9488738.15655353.18499658.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005663	DNA replication factor C complex	21873635.	IBA	Component
GO:0005663	DNA replication factor C complex	9488738.	IDA	Component
GO:0006260	DNA replication	-	TAS	Process
GO:0006261	DNA-dependent DNA replication	21873635.	IBA	Process
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	Process
GO:0006297	nucleotide-excision repair, DNA gap filling	-	TAS	Process
GO:0019899	enzyme binding	-	IEA	Function
GO:0019985	translesion synthesis	-	TAS	Process
GO:0031390	Ctf18 RFC-like complex	12930902.	IDA	Component
GO:0032201	telomere maintenance via semi-conservative replication	-	TAS	Process
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	Process
GO:0042276	error-prone translesion synthesis	-	TAS	Process
GO:0042769	DNA damage response, detection of DNA damage	-	TAS	Process
GO:0043142	single-stranded DNA-dependent ATPase activity	12930902.	IDA	Function
GO:0070987	error-free translesion synthesis	-	TAS	Process
GO:1900264	positive regulation of DNA-directed DNA polymerase activity	12930902.	IDA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.