EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr10	95633650	Splice_Site	novel	X187_splice	0.48
ACC	chr10	95626748	Missense_Mutation	novel	M369I	0.22
BLCA	chr10	95643170	Missense_Mutation	novel	S42F	0.2
BLCA	chr10	95610214	Missense_Mutation	novel	G730D	0.29
BLCA	chr10	95621164	Missense_Mutation	novel	A445V	0.34
BLCA	chr10	95653405	Splice_Region	novel		0.06
BLCA	chr10	95616504	Silent	NA	I526I	0.57
BLCA	chr10	95614159	Splice_Region	novel	V536V	0.44
BLCA	chr10	95606685	3'UTR	novel		0.22
BRCA	chr10	95626747	Missense_Mutation	NA	A370T	0.11
BRCA	chr10	95632967	Missense_Mutation	novel	D267V	0.05
BRCA	chr10	95637364	Missense_Mutation	novel	R126C	0.09
BRCA	chr10	95621209	Frame_Shift_Del	novel	*L423Hfs4**	0.12
BRCA	chr10	95611303	Missense_Mutation	NA	I688T	0.42
BRCA	chr10	95643044	Missense_Mutation	NA	R84P	0.33
BRCA	chr10	95606902	Nonsense_Mutation	NA	G750*	0.41
BRCA	chr10	95606560	3'UTR	novel		0.33
CESC	chr10	95613984	Missense_Mutation	NA	D595H	0.19
CESC	chr10	95637105	Silent	novel	I182I	0.48
COAD	chr10	95606803	Missense_Mutation	NA	L783I	0.35
COAD	chr10	95621221	Nonsense_Mutation	novel	L426*	0.58
COAD	chr10	95626746	Missense_Mutation	novel	A370V	0.25
COAD	chr10	95606908	Missense_Mutation	rs773903524	A748T	0.06
COAD	chr10	95637358	Missense_Mutation	NA	R128C	0.44
COAD	chr10	95606857	Nonsense_Mutation	novel	R765*	0.22
COAD	chr10	95614095	Missense_Mutation	novel	R558C	0.06
COAD	chr10	95606560	3'UTR	novel		0.41
COAD	chr10	95643068	Missense_Mutation	novel	K76R	0.06
COAD	chr10	95613751	Missense_Mutation	novel	R638S	0.11
COAD	chr10	95637358	Missense_Mutation	NA	R128C	0.4
COAD	chr10	95633564	Missense_Mutation	NA	I215T	0.21
COAD	chr10	95637332	Silent	NA	S136S	0.2
ESCA	chr10	95626744	Nonsense_Mutation	novel	R371*	0.08
ESCA	chr10	95613860	Missense_Mutation	novel	R602I	0.17
GBM	chr10	95626705	Missense_Mutation	novel	Q384E	0.25
GBM	chr10	95621034	Silent	novel	P488P	0.42
GBM	chr10	95637099	Silent	NA	A184A	0.72
GBM	chr10	95637370	Nonsense_Mutation	novel	K124*	0.16
GBM	chr10	95613998	Missense_Mutation	novel	S590Y	0.45
GBM	chr10	95614131	Missense_Mutation	novel	C546S	0.07
HNSC	chr10	95606571	3'UTR	novel		0.5
HNSC	chr10	95614026	Missense_Mutation	rs777991529	E581K	0.05
KIRC	chr10	95614101	Missense_Mutation	NA	I556V	0.29
KIRP	chr10	95625441	Silent	novel	I389I	0.1
KIRP	chr10	95606701	3'UTR	novel		0.63
LAML	chr10	95613799	Silent	novel	R622R	0.04
LAML	chr10	95637413	Silent	novel	G109G	0.04
LIHC	chr10	95643017	Missense_Mutation	NA	G93E	0.46
LUAD	chr10	95653391	5'UTR	novel		0.11
LUAD	chr10	95628403	Nonsense_Mutation	NA	K300*	0.36
LUAD	chr10	95621061	Silent	novel	I479I	0.12
LUAD	chr10	95613766	Silent	NA	I633I	0.28
LUAD	chr10	95610293	Splice_Site	novel	X704_splice	0.17
LUSC	chr10	95643127	Silent	novel	T56T	0.26
LUSC	chr10	95621087	Frame_Shift_Del	novel	*L464Ffs11**	0.13
LUSC	chr10	95627487	Missense_Mutation	novel	E345Q	0.2
LUSC	chr10	95606826	Missense_Mutation	novel	S775L	0.44
LUSC	chr10	95653352	Missense_Mutation	novel	G9A	0.07
LUSC	chr10	95626731	Missense_Mutation	novel	R375M	0.38
LUSC	chr10	95637158	Nonsense_Mutation	novel	G165*	0.18
LUSC	chr10	95637378	Missense_Mutation	novel	A121V	0.32
LUSC	chr10	95606698	3'UTR	novel		0.28
OV	chr10	95621063	Missense_Mutation	novel	I479F	0.37
OV	chr10	95653384	5'UTR	novel		0.09
OV	chr10	95610234	Silent	novel	A723A	0.15
OV	chr10	95621067	Silent	novel	L477L	0.23
OV	chr10	95621113	Missense_Mutation	novel	K462R	0.05
OV	chr10	95653392	5'UTR	novel		0.14
OV	chr10	95614118	Missense_Mutation	novel	K550R	0.08
OV	chr10	95616547	Missense_Mutation	novel	S512I	0.16
PAAD	chr10	95637328	Missense_Mutation	NA	R138W	0.17
PRAD	chr10	95621132	Missense_Mutation	rs763868475	R456C	0.18
READ	chr10	95627530	Silent	NA	G330G	0.22
SARC	chr10	95643131	Missense_Mutation	rs754880517	R55H	0.5
SKCM	chr10	95626722	Missense_Mutation	novel	A378V	0.21
SKCM	chr10	95611373	Nonsense_Mutation	rs751181507	R665*	0.24
SKCM	chr10	95611285	Missense_Mutation	NA	S694F	0.1
SKCM	chr10	95643132	Missense_Mutation	NA	R55C	0.06
SKCM	chr10	95613858	Missense_Mutation	novel	D603N	0.43
SKCM	chr10	95633577	Missense_Mutation	NA	L211F	0.32
SKCM	chr10	95611433	Missense_Mutation	NA	H645Y	0.16
SKCM	chr10	95633596	Silent	novel	N204N	0.81
SKCM	chr10	95643007	Silent	novel	A96A	0.26
SKCM	chr10	95643013	Silent	NA	R94R	0.47
SKCM	chr10	95637337	Nonsense_Mutation	NA	Q135*	0.11
SKCM	chr10	95606671	3'UTR	novel		0.44
SKCM	chr10	95628408	Missense_Mutation	novel	G298E	0.52
SKCM	chr10	95628409	Missense_Mutation	novel	G298R	0.53
SKCM	chr10	95637312	Missense_Mutation	novel	S143L	0.18
STAD	chr10	95626697	Splice_Region	novel		0.17
STAD	chr10	95626700	Splice_Site	novel	X384_splice	0.16
STAD	chr10	95643055	Silent	NA	A80A	0.14
STAD	chr10	95611373	Nonsense_Mutation	rs751181507	R665*	0.42
STAD	chr10	95643055	Silent	NA	A80A	0.37
STAD	chr10	95643015	Missense_Mutation	NA	R94C	0.26
STAD	chr10	95606560	3'UTR	novel		0.5
STAD	chr10	95614101	Missense_Mutation	NA	I556V	0.36
STAD	chr10	95637327	Missense_Mutation	NA	R138Q	0.3
STAD	chr10	95637358	Missense_Mutation	NA	R128C	0.46
STAD	chr10	95653405	Splice_Region	novel		0.07
STAD	chr10	95643144	Missense_Mutation	rs755553870	V51I	0.29
STAD	chr10	95643080	Missense_Mutation	NA	R72I	0.28
STAD	chr10	95633019	Missense_Mutation	novel	A250T	0.28
STAD	chr10	95627470	Silent	NA	G350G	0.15
STAD	chr10	95632964	Missense_Mutation	NA	V268A	0.17
STAD	chr10	95610250	Frame_Shift_Del	novel	*C718Lfs35**	0.06
STAD	chr10	95611291	Missense_Mutation	NA	G692D	0.07
TGCT	chr10	95610264	Silent	rs147842812	H713H	0.35
THCA	chr10	95637358	Frame_Shift_Del	novel	*R128Afs21**	0.04
THCA	chr10	95637360	Frame_Shift_Del	novel	*R126Afs3**	0.04
THYM	chr10	95606648	3'UTR	novel		0.25
UCEC	chr10	95610209	Missense_Mutation	rs760203992	R732C	0.41
UCEC	chr10	95606770	Missense_Mutation	novel	T794A	0.26
UCEC	chr10	95621189	Missense_Mutation	novel	A437S	0.09
UCEC	chr10	95621051	Missense_Mutation	rs764145947	R483C	0.29
UCEC	chr10	95611435	Missense_Mutation	novel	I644T	0.07
UCEC	chr10	95611436	Frame_Shift_Ins	novel	*I644Afs12**	0.07
UCEC	chr10	95628433	Missense_Mutation	rs368147360	G290R	0.42
UCEC	chr10	95637197	Missense_Mutation	novel	A152S	0.44
UCEC	chr10	95606908	Missense_Mutation	rs773903524	A748T	0.37
UCEC	chr10	95637328	Missense_Mutation	NA	R138W	0.46
UCEC	chr10	95611423	Frame_Shift_Ins	novel	*P648Lfs11**	0.13
UCEC	chr10	95613996	Missense_Mutation	rs755594128	E591K	0.38
UCEC	chr10	95628474	Frame_Shift_Del	NA	*P276Qfs20**	0.1
UCEC	chr10	95611423	Frame_Shift_Ins	novel	*P648Hfs24**	0.34
UCEC	chr10	95611425	Frame_Shift_Del	novel	*G647Afs20**	0.1
UCEC	chr10	95606791	Missense_Mutation	NA	L787I	0.41
UCEC	chr10	95614137	Missense_Mutation	NA	D544Y	0.33
UCEC	chr10	95616540	Silent	rs777553274	R514R	0.36
UCEC	chr10	95637285	Splice_Site	NA	X151_splice	0.33
UCEC	chr10	95611419	In_Frame_Ins	novel	K649delinsNLVR	0.04
UCEC	chr10	95633510	Missense_Mutation	novel	S233N	0.3
UCEC	chr10	95611372	Missense_Mutation	rs766264810	R665Q	0.13
UCEC	chr10	95653290	Missense_Mutation	rs113678237	H30Y	0.44
UCEC	chr10	95614095	Missense_Mutation	novel	R558C	0.39
UCEC	chr10	95606588	3'UTR	novel		0.31
UCEC	chr10	95626746	Missense_Mutation	novel	A370V	0.11
UCEC	chr10	95606564	3'UTR	novel		0.38
UCEC	chr10	95626743	Missense_Mutation	rs745614904	R371Q	0.34
UCEC	chr10	95621050	Missense_Mutation	rs756168752	R483H	0.48
UCEC	chr10	95637409	Nonsense_Mutation	novel	E111*	0.52
UCEC	chr10	95611269	Silent	rs780721947	I699I	0.52
UCEC	chr10	95643091	Silent	rs768807587	K68K	0.45
UCEC	chr10	95606560	3'UTR	novel		0.33
UCEC	chr10	95611302	Silent	NA	I688I	0.46
UCEC	chr10	95621148	Silent	NA	S450S	0.31
UCEC	chr10	95625425	Missense_Mutation	NA	L395M	0.37
UCEC	chr10	95637105	Silent	novel	I182I	0.21
UCEC	chr10	95616595	Missense_Mutation	novel	A496V	0.35
UCEC	chr10	95643060	Missense_Mutation	novel	S79G	0.45
UCEC	chr10	95614127	Missense_Mutation	rs199668897	R547H	0.29
UCEC	chr10	95625409	Missense_Mutation	novel	R400H	0.09
UCEC	chr10	95628380	Silent	novel	G307G	0.2
UCEC	chr10	95625378	Missense_Mutation	novel	D410E	0.29
UCEC	chr10	95606560	3'UTR	novel		0.33
UCEC	chr10	95626744	Nonsense_Mutation	novel	R371*	0.08
UCEC	chr10	95633631	Missense_Mutation	novel	D193H	0.12
UCEC	chr10	95633632	Missense_Mutation	novel	L192F	0.12
UCEC	chr10	95643021	Missense_Mutation	NA	L92V	0.68
UCEC	chr10	95637170	Missense_Mutation	novel	C161R	0.2
UCEC	chr10	95611415	Missense_Mutation	novel	A651T	0.07
UCEC	chr10	95611372	Missense_Mutation	rs766264810	R665Q	0.06
UCEC	chr10	95606526	3'UTR	novel		0.34
UCEC	chr10	95606908	Missense_Mutation	rs773903524	A748T	0.38
UCEC	chr10	95633562	Missense_Mutation	novel	V216I	0.27
UCEC	chr10	95653348	Silent	novel	F10F	0.29
UCEC	chr10	95643063	Missense_Mutation	rs762588270	G78S	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
CHOL	DEL	0.1944	0.048655
COAD	DEL	0.1774	9.4741e-07
MESO	DEL	0.2874	0.00015289
PAAD	DEL	0.1304	0.169
READ	DEL	0.2424	0.014135
THCA	DEL	0.016	0.011063
THYM	DEL	0.0325	0.10563
UCS	DEL	0.3036	0.1218

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.0007	Kaplan-Meier Survival Analysis
SARC	0.0022	Kaplan-Meier Survival Analysis
MESO	0.00028	Kaplan-Meier Survival Analysis
ACC	0.0023	Kaplan-Meier Survival Analysis
LUSC	0.012	Kaplan-Meier Survival Analysis
BRCA	0.024	Kaplan-Meier Survival Analysis
KIRP	0.00091	Kaplan-Meier Survival Analysis
UCEC	0.0029	Kaplan-Meier Survival Analysis
LIHC	0.0019	Kaplan-Meier Survival Analysis
LGG	0.00043	Kaplan-Meier Survival Analysis
LUAD	0.033	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000059573 (Gene tree)
Gene ID: 5832
Gene Symbol: ALDH18A1
Alias: P5CS|GSAS|PYCS|SPG9
Full Name: aldehyde dehydrogenase 18 family member A1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 50,882 bases
Position: chr10:95,605,929-95,656,810
Accession: 9722
RBP type: non-canonical RBP
Summary: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000489386	ALDH18A1-205	543	-	-	- (aa)	-	-
ENST00000371221	ALDH18A1-201	3337	XM_024448096	ENSP00000360265	793 (aa)	XP_024303864	P54886
ENST00000485428	ALDH18A1-204	726	-	-	- (aa)	-	-
ENST00000371224	ALDH18A1-202	3359	XM_024448094	ENSP00000360268	795 (aa)	XP_024303862	P54886
ENST00000483788	ALDH18A1-203	750	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000059573's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00330	Arginine and proline metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01230	Biosynthesis of amino acids	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000059573	Metabolism	8E-11	24816252

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000059573	rs56322409	10	95636205	T	Blood metabolite levels	24816252	[0.0071-0.0149] unit decrease	0.011	EFO_0005664

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000059573's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000059573	ALDH18A1	91	55.372	WBGene00011938	alh-13	89	55.372	Caenorhabditis_elegans

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004349	glutamate 5-kinase activity	11092761.	IDA	Function
GO:0004349	glutamate 5-kinase activity	26297558.	IMP	Function
GO:0004350	glutamate-5-semialdehyde dehydrogenase activity	21873635.	IBA	Function
GO:0004350	glutamate-5-semialdehyde dehydrogenase activity	11092761.	IDA	Function
GO:0004350	glutamate-5-semialdehyde dehydrogenase activity	26297558.	IMP	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	26297558.26320891.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006536	glutamate metabolic process	11092761.	IMP	Process
GO:0006561	proline biosynthetic process	11092761.26297558.	IMP	Process
GO:0006592	ornithine biosynthetic process	11092761.26297558.	IMP	Process
GO:0008652	cellular amino acid biosynthetic process	-	TAS	Process
GO:0016310	phosphorylation	-	IEA	Process
GO:0019240	citrulline biosynthetic process	11092761.26297558.	IMP	Process
GO:0042802	identical protein binding	26297558.	IDA	Function
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0055129	L-proline biosynthetic process	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.