EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22025453	Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.	Mol Carcinog	2012 Nov	Sand M	doi: 10.1002/mc.20861

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	234406033	Nonsense_Mutation	rs201259533	R1287*	0.52
BLCA	chr1	234398433	Missense_Mutation	novel	Q1398E	0.32
BLCA	chr1	234478199	Missense_Mutation	novel	C302Y	0.24
BLCA	chr1	234457731	Missense_Mutation	novel	S553L	0.23
BLCA	chr1	234429479	Silent	novel	L936L	0.16
BLCA	chr1	234410462	Missense_Mutation	NA	Q1259E	0.12
BLCA	chr1	234463858	Missense_Mutation	novel	L460I	0.46
BLCA	chr1	234457721	Silent	NA	L556L	0.14
BLCA	chr1	234425688	Silent	NA	I1143I	0.18
BLCA	chr1	234459280	Missense_Mutation	novel	G528R	0.3
BLCA	chr1	234429573	Missense_Mutation	novel	T905I	0.22
BLCA	chr1	234401222	Missense_Mutation	novel	F1344L	0.28
BRCA	chr1	234420812	Missense_Mutation	NA	D1149N	0.13
BRCA	chr1	234420784	Missense_Mutation	NA	R1158H	0.16
BRCA	chr1	234430277	Missense_Mutation	NA	Q807E	0.37
BRCA	chr1	234393675	Missense_Mutation	rs754357411	S1469L	0.14	SpoU_methylase
BRCA	chr1	234429325	Splice_Site	NA	X958_splice	0.18
BRCA	chr1	234472776	Missense_Mutation	novel	D323H	0.06
BRCA	chr1	234429254	Missense_Mutation	novel	S981T	0.1
BRCA	chr1	234457673	Missense_Mutation	NA	W572C	0.13
BRCA	chr1	234430160	Missense_Mutation	novel	Q846E	0.47
BRCA	chr1	234430277	Nonsense_Mutation	novel	Q807*	0.43
BRCA	chr1	234401216	Frame_Shift_Ins	NA	*A1346Cfs26**	0.27
BRCA	chr1	234401234	Missense_Mutation	NA	Q1340E	0.25
BRCA	chr1	234418189	Silent	novel	F1200F	0.04
BRCA	chr1	234427337	Silent	rs141887124	A1101A	0.12
BRCA	chr1	234420767	Missense_Mutation	novel	L1164V	0.16
CESC	chr1	234460263	Splice_Region	NA	L511L	0.08
CESC	chr1	234433556	Missense_Mutation	rs772590642	R750C	0.37
CESC	chr1	234393404	Silent	NA	Q1506Q	0.32
CESC	chr1	234429523	Missense_Mutation	rs563481719	V922L	0.26
CESC	chr1	234429637	Frame_Shift_Del	novel	I884*	0.47
CESC	chr1	234457669	Missense_Mutation	novel	E574K	0.4
CESC	chr1	234401180	Splice_Site	novel	X1357_splice	0.27
CESC	chr1	234430159	Missense_Mutation	NA	Q846L	0.12
COAD	chr1	234391511	3'UTR	novel		0.25
COAD	chr1	234467513	Nonsense_Mutation	NA	E413*	0.37
COAD	chr1	234446810	Silent	NA	A709A	0.41
COAD	chr1	234430187	Missense_Mutation	rs750889517	P837S	0.29
COAD	chr1	234446864	Nonsense_Mutation	NA	C691*	0.27
COAD	chr1	234429271	Missense_Mutation	NA	K975N	0.18
COAD	chr1	234460285	Missense_Mutation	rs763944442	G504D	0.23
COAD	chr1	234463881	Missense_Mutation	NA	K452R	0.12
COAD	chr1	234467611	Missense_Mutation	NA	Y380C	0.13
COAD	chr1	234448502	Missense_Mutation	rs779403009	E647K	0.13
COAD	chr1	234467519	Frame_Shift_Del	novel	*S411Hfs12**	0.06
COAD	chr1	234393717	Missense_Mutation	NA	A1455V	0.21
COAD	chr1	234427717	Missense_Mutation	NA	N1037I	0.37
ESCA	chr1	234398525	Missense_Mutation	novel	S1367L	0.1
ESCA	chr1	234427764	Splice_Region	novel	I1021I	0.25
ESCA	chr1	234393418	Missense_Mutation	NA	D1502N	0.34	SpoU_methylase
GBM	chr1	234429455	Silent	novel	V944V	0.31
GBM	chr1	234418157	Missense_Mutation	novel	I1211R	0.1
GBM	chr1	234405910	Missense_Mutation	rs775037936	G1328R	0.39
GBM	chr1	234433555	Missense_Mutation	rs201722269	R750H	0.44
GBM	chr1	234446840	Missense_Mutation	novel	L699F	0.22
GBM	chr1	234471196	Missense_Mutation	novel	E364A	0.18
HNSC	chr1	234418119	Missense_Mutation	novel	Q1224E	0.18
HNSC	chr1	234429267	Missense_Mutation	novel	I977V	0.29
HNSC	chr1	234393460	Missense_Mutation	novel	G1488W	0.14	SpoU_methylase
HNSC	chr1	234460328	Missense_Mutation	NA	L490I	0.28
HNSC	chr1	234429597	Frame_Shift_Del	novel	*Q892Lfs4**	0.17
HNSC	chr1	234393775	Missense_Mutation	novel	P1436S	0.42
HNSC	chr1	234450522	Silent	novel	S589S	0.35
HNSC	chr1	234410482	Nonsense_Mutation	novel	S1252*	0.1
HNSC	chr1	234465691	Missense_Mutation	novel	L422F	0.18
HNSC	chr1	234393398	Silent	novel	L1508L	0.13
HNSC	chr1	234448480	Missense_Mutation	novel	S654N	0.21
KIRC	chr1	234429298	Silent	NA	C966C	0.07
KIRC	chr1	234406023	Missense_Mutation	NA	A1290V	0.09
KIRC	chr1	234446832	Missense_Mutation	NA	C702Y	0.19
KIRC	chr1	234429282	Missense_Mutation	NA	M972L	0.21
KIRC	chr1	234401188	Missense_Mutation	NA	C1355Y	0.31
KIRP	chr1	234406039	Frame_Shift_Ins	novel	*S1285Lfs8**	0.14
LGG	chr1	234420725	Missense_Mutation	novel	V1178L	0.13
LGG	chr1	234410474	Missense_Mutation	novel	D1255H	0.43
LIHC	chr1	234401184	Silent	NA	L1356L	0.59
LIHC	chr1	234405903	Missense_Mutation	novel	G1330E	0.34
LIHC	chr1	234405988	Missense_Mutation	novel	K1302E	0.45
LIHC	chr1	234429532	Silent	novel	L919L	0.24
LIHC	chr1	234398517	Missense_Mutation	novel	I1370F	0.13
LUAD	chr1	234391508	3'UTR	novel		0.17
LUAD	chr1	234393430	Nonsense_Mutation	NA	Q1498*	0.09	SpoU_methylase
LUAD	chr1	234393370	Missense_Mutation	NA	L1518V	0.22	SpoU_methylase
LUAD	chr1	234393823	Missense_Mutation	rs201832385	E1420K	0.1
LUAD	chr1	234410528	Missense_Mutation	NA	E1237K	0.15
LUAD	chr1	234430211	Nonsense_Mutation	NA	Q829*	0.13
LUAD	chr1	234463850	Silent	NA	P462P	0.31
LUAD	chr1	234393478	Missense_Mutation	novel	R1482G	0.16	SpoU_methylase
LUAD	chr1	234393659	Silent	NA	P1474P	0.27
LUAD	chr1	234448524	Missense_Mutation	NA	M639I	0.23
LUAD	chr1	234430093	Missense_Mutation	novel	C868F	0.47
LUAD	chr1	234406009	Nonsense_Mutation	novel	K1295*	0.2
LUAD	chr1	234430271	Missense_Mutation	NA	V809L	0.18
LUAD	chr1	234457721	Silent	NA	L556L	0.59
LUAD	chr1	234446824	Missense_Mutation	novel	K705E	0.11
LUAD	chr1	234471251	Missense_Mutation	NA	V346I	0.43
LUAD	chr1	234448517	Missense_Mutation	NA	L642V	0.13
LUSC	chr1	234429571	Missense_Mutation	novel	L906V	0.24
LUSC	chr1	234446876	Silent	novel	K687K	0.11
LUSC	chr1	234392438	Missense_Mutation	NA	E1559K	0.4	SpoU_methylase
LUSC	chr1	234425754	Silent	novel	V1121V	0.29
LUSC	chr1	234430189	Missense_Mutation	NA	G836V	0.18
LUSC	chr1	234429493	Missense_Mutation	novel	A932S	0.44
LUSC	chr1	234427578	Splice_Region	NA	Q1083Q	0.18
LUSC	chr1	234433460	Missense_Mutation	NA	L782V	0.18
LUSC	chr1	234433556	Missense_Mutation	NA	R750S	0.21
LUSC	chr1	234433460	Missense_Mutation	NA	L782V	0.13
LUSC	chr1	234446955	Missense_Mutation	novel	N661I	0.42
LUSC	chr1	234398456	Missense_Mutation	rs527984546	A1390V	0.35
LUSC	chr1	234429671	Missense_Mutation	novel	L872F	0.44
LUSC	chr1	234425731	Missense_Mutation	NA	G1129V	0.32
LUSC	chr1	234460338	Silent	novel	P486P	0.35
LUSC	chr1	234446855	Silent	novel	L694L	0.37
LUSC	chr1	234391544	3'UTR	novel		0.09
LUSC	chr1	234393370	Missense_Mutation	NA	L1518V	0.26	SpoU_methylase
OV	chr1	234430147	Missense_Mutation	rs201549800	T850M	0.03
OV	chr1	234418195	Silent	NA	A1198A	0.07
OV	chr1	234448527	Silent	NA	L638L	0.11
OV	chr1	234406069	Nonsense_Mutation	novel	*V1275Kfs3**	0.05
OV	chr1	234406071	Frame_Shift_Ins	novel	*V1274Dfs15**	0.03
OV	chr1	234429609	Nonsense_Mutation	NA	W893*	0.91
OV	chr1	234429442	Missense_Mutation	novel	H949Y	0.16
OV	chr1	234430255	Missense_Mutation	novel	A814D	0.08
OV	chr1	234433459	Frame_Shift_Ins	novel	*L782Pfs50**	0.06
OV	chr1	234429553	Missense_Mutation	NA	S912C	0.2
OV	chr1	234420754	Missense_Mutation	NA	V1168A	0.19
PAAD	chr1	234393659	Silent	rs770859684	P1474P	0.28
PAAD	chr1	234450453	Silent	novel	E612E	0.12
PAAD	chr1	234467616	Silent	novel	C378C	0.23
PRAD	chr1	234420702	Splice_Region	NA	Q1185Q	0.33
PRAD	chr1	234401239	Missense_Mutation	rs201389692	R1338H	0.18
PRAD	chr1	234398530	Silent	novel	R1365R	0.63
PRAD	chr1	234401181	Missense_Mutation	novel	E1357D	0.37
PRAD	chr1	234420796	Missense_Mutation	rs766128155	K1154T	0.34
READ	chr1	234446865	Missense_Mutation	rs770281284	C691F	0.44
READ	chr1	234457690	Nonsense_Mutation	rs559685099	R567*	0.05
READ	chr1	234450550	Missense_Mutation	novel	R580P	0.14
READ	chr1	234401250	Missense_Mutation	NA	K1334N	0.41
SARC	chr1	234425688	Silent	NA	I1143I	0.27
SARC	chr1	234392537	Missense_Mutation	novel	L1526I	0.31	SpoU_methylase
SKCM	chr1	234427657	Missense_Mutation	rs765575331	G1057E	0.36
SKCM	chr1	234427658	Missense_Mutation	novel	G1057R	0.37
SKCM	chr1	234460328	Silent	novel	L490L	0.47
SKCM	chr1	234437318	Missense_Mutation	NA	S730F	0.62
SKCM	chr1	234430173	Silent	novel	F841F	0.24
SKCM	chr1	234418122	Missense_Mutation	NA	P1223S	0.22
SKCM	chr1	234391628	Silent	novel	I1605I	0.25
SKCM	chr1	234460361	Missense_Mutation	NA	S479R	0.16
SKCM	chr1	234460363	Missense_Mutation	NA	T478I	0.1
SKCM	chr1	234429314	Missense_Mutation	NA	S961F	0.07
SKCM	chr1	234429246	Nonsense_Mutation	NA	Q984*	0.39
SKCM	chr1	234406033	Nonsense_Mutation	rs201259533	R1287*	0.25
SKCM	chr1	234433444	Missense_Mutation	NA	S787F	0.57
SKCM	chr1	234393668	Silent	rs752798421	I1471I	0.73
SKCM	chr1	234433457	Missense_Mutation	novel	L783M	0.07
SKCM	chr1	234450521	Missense_Mutation	NA	P590S	0.22
SKCM	chr1	234429577	Missense_Mutation	NA	H904Y	0.32
SKCM	chr1	234429675	Missense_Mutation	novel	V871A	0.19
SKCM	chr1	234406048	Missense_Mutation	NA	H1282Y	0.29
SKCM	chr1	234427355	Silent	NA	N1095N	0.47
SKCM	chr1	234398381	Splice_Site	rs768819942	X1415_splice	0.1
SKCM	chr1	234393668	Silent	rs752798421	I1471I	0.21
SKCM	chr1	234430185	Silent	NA	P837P	0.05
SKCM	chr1	234430186	Missense_Mutation	novel	P837L	0.05
SKCM	chr1	234401196	Silent	NA	K1352K	0.63
SKCM	chr1	234391711	Nonsense_Mutation	novel	Q1578*	0.39	SpoU_methylase
SKCM	chr1	234459286	Silent	NA	L526L	0.16
STAD	chr1	234429581	Frame_Shift_Del	rs764841940	*K902Nfs25**	0.23
STAD	chr1	234425712	Missense_Mutation	novel	K1135N	0.09
STAD	chr1	234391608	Missense_Mutation	NA	Q1612L	0.54
STAD	chr1	234427636	Frame_Shift_Del	novel	*N1064Ifs30**	0.29
STAD	chr1	234430215	Silent	novel	E827E	0.07
STAD	chr1	234418144	Silent	NA	I1215I	0.12
STAD	chr1	234405970	Nonsense_Mutation	NA	E1308*	0.18
STAD	chr1	234392528	Missense_Mutation	NA	Y1529H	0.14	SpoU_methylase
STAD	chr1	234429176	Missense_Mutation	NA	A1007V	0.17
STAD	chr1	234405979	Missense_Mutation	NA	S1305R	0.32
STAD	chr1	234450448	Missense_Mutation	novel	V614G	0.06
STAD	chr1	234467532	Missense_Mutation	NA	K406N	0.13
STAD	chr1	234393682	Missense_Mutation	NA	V1467M	0.25	SpoU_methylase
STAD	chr1	234427585	Missense_Mutation	NA	R1081H	0.21
STAD	chr1	234429277	Silent	rs757993562	A973A	0.19
STAD	chr1	234433434	Missense_Mutation	NA	H790Q	0.27
STAD	chr1	234430284	Silent	novel	S804S	0.25
THCA	chr1	234467604	In_Frame_Ins	novel	M383_F384insQISKM	0.18
THCA	chr1	234392525	Missense_Mutation	NA	L1530V	0.16	SpoU_methylase
THYM	chr1	234425721	Missense_Mutation	rs779595383	M1132I	0.26
UCEC	chr1	234393418	Missense_Mutation	NA	D1502N	0.31	SpoU_methylase
UCEC	chr1	234393762	Missense_Mutation	rs190205796	R1440H	0.35
UCEC	chr1	234433539	Silent	NA	L755L	0.3
UCEC	chr1	234478229	Missense_Mutation	novel	V292A	0.29
UCEC	chr1	234429487	Nonsense_Mutation	NA	E934*	0.27
UCEC	chr1	234406032	Missense_Mutation	rs779593952	R1287Q	0.41
UCEC	chr1	234471223	Missense_Mutation	novel	N355S	0.08
UCEC	chr1	234420746	Nonsense_Mutation	rs763820689	R1171*	0.3
UCEC	chr1	234446957	Missense_Mutation	NA	E660D	0.42
UCEC	chr1	234427727	Nonsense_Mutation	novel	G1034*	0.53
UCEC	chr1	234429475	Missense_Mutation	novel	V938F	0.41
UCEC	chr1	234429219	Missense_Mutation	novel	A993S	0.41
UCEC	chr1	234393708	Missense_Mutation	novel	G1458V	0.16
UCEC	chr1	234391676	Missense_Mutation	NA	Q1589H	0.29	SpoU_methylase
UCEC	chr1	234418208	Missense_Mutation	NA	R1194M	0.2
UCEC	chr1	234465676	Frame_Shift_Ins	novel	*E428Kfs14**	0.07
UCEC	chr1	234472766	Missense_Mutation	NA	L326P	0.37
UCEC	chr1	234391544	3'UTR	novel		0.17
UCEC	chr1	234401216	Frame_Shift_Ins	NA	*A1346Cfs26**	0.39
UCEC	chr1	234450472	Missense_Mutation	novel	V606E	0.39
UCEC	chr1	234467605	Missense_Mutation	NA	R382I	0.36
UCEC	chr1	234406001	Silent	novel	L1297L	0.05
UCEC	chr1	234420784	Missense_Mutation	NA	R1158H	0.35
UCEC	chr1	234429560	Silent	novel	T909T	0.2
UCEC	chr1	234467570	Nonsense_Mutation	novel	E394*	0.47
UCEC	chr1	234401179	Splice_Site	novel	X1357_splice	0.22
UCEC	chr1	234437339	Missense_Mutation	novel	M723T	0.33
UCEC	chr1	234418192	Silent	novel	G1199G	0.15
UCEC	chr1	234398531	Missense_Mutation	rs139118500	R1365H	0.22
UCEC	chr1	234406065	Missense_Mutation	novel	L1276P	0.23
UCEC	chr1	234467586	Frame_Shift_Ins	novel	*N388Kfs17**	0.2
UCEC	chr1	234391526	3'UTR	novel		0.33
UCEC	chr1	234425672	Splice_Site	novel	X1148_splice	0.34
UCEC	chr1	234418146	Missense_Mutation	novel	I1215L	0.29
UCEC	chr1	234467605	Missense_Mutation	NA	R382I	0.2
UCEC	chr1	234391666	Missense_Mutation	rs560732693	R1593C	0.53	SpoU_methylase
UCEC	chr1	234393723	Missense_Mutation	rs372748386	R1453H	0.43
UCEC	chr1	234406032	Missense_Mutation	rs779593952	R1287Q	0.39
UCEC	chr1	234391593	Missense_Mutation	novel	G1617E	0.33
UCEC	chr1	234398476	Missense_Mutation	novel	F1383L	0.59
UCEC	chr1	234392462	Missense_Mutation	novel	D1551Y	0.15	SpoU_methylase
UCEC	chr1	234465704	Missense_Mutation	novel	I418S	0.5
UCEC	chr1	234467570	Nonsense_Mutation	novel	E394*	0.21
UCEC	chr1	234410474	Missense_Mutation	novel	D1255N	0.46
UCEC	chr1	234472767	Silent	rs779272003	L326L	0.3
UCEC	chr1	234406032	Missense_Mutation	rs779593952	R1287Q	0.56
UCEC	chr1	234467569	Missense_Mutation	NA	E394G	0.46
UCEC	chr1	234427326	Missense_Mutation	NA	V1105A	0.34
UCEC	chr1	234398381	Splice_Site	rs768819942	X1415_splice	0.24
UCEC	chr1	234437373	Splice_Site	novel	X712_splice	0.27
UCEC	chr1	234429556	Missense_Mutation	novel	G911W	0.22
UCEC	chr1	234393718	Missense_Mutation	novel	A1455S	0.07
UCEC	chr1	234429277	Silent	rs757993562	A973A	0.23
UCEC	chr1	234446976	Splice_Site	NA	X654_splice	0.26
UCEC	chr1	234427687	Missense_Mutation	novel	W1047S	0.63
UCEC	chr1	234401253	Missense_Mutation	NA	K1333N	0.27
UCEC	chr1	234406008	Nonsense_Mutation	novel	*K1295Ifs2**	0.05
UCEC	chr1	234410474	Missense_Mutation	NA	D1255Y	0.27
UCEC	chr1	234429642	Missense_Mutation	novel	G882E	0.35
UCEC	chr1	234450468	Silent	novel	K607K	0.06
UCEC	chr1	234433486	Missense_Mutation	novel	G773D	0.12
UCEC	chr1	234448491	Missense_Mutation	novel	K650N	0.37
UCEC	chr1	234391488	3'UTR	novel		0.21
UCEC	chr1	234457692	Missense_Mutation	novel	G566E	0.35
UCEC	chr1	234430263	Silent	novel	S811S	0.24

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.125	0.0017831
KIRC	DEL	0.0663	0.018371
LGG	DEL	0.0409	0.11599
LIHC	AMP	0.6676	4.3428e-09
OV	AMP	0.5078	7.0072e-14
PCPG	DEL	0.0926	0.12617
PRAD	DEL	0.0894	0.00015401
READ	AMP	0.2424	0.14328
SARC	DEL	0.3113	2.6086e-08
TGCT	DEL	0.0267	0.16985
THYM	AMP	0.187	0.24554
UCEC	AMP	0.3785	2.3921e-06

Survival Analysis

Cancer	P-value	Q-value
THYM	0.021	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.017	Kaplan-Meier Survival Analysis
ACC	0.0045	Kaplan-Meier Survival Analysis
LUSC	0.02	Kaplan-Meier Survival Analysis
PAAD	0.013	Kaplan-Meier Survival Analysis
READ	0.026	Kaplan-Meier Survival Analysis
LAML	0.03	Kaplan-Meier Survival Analysis
LIHC	0.0082	Kaplan-Meier Survival Analysis
LGG	0.0068	Kaplan-Meier Survival Analysis
THCA	0.041	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000059588 (Gene tree)
Gene ID: 6894
Gene Symbol: TARBP1
Alias: TRP-185|TRM3|TRMT3
Full Name: TAR (HIV-1) RNA binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 87,846 bases
Position: chr1:234,391,313-234,479,158
Accession: 11568
RBP type: canonical RBP
Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000040877	SpoU_methylase	PF00588.19	4.3e-30	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8846792	The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA.	EMBO J	1995 Dec 1	Wu-Baer F	-
1936997	tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185.	Genes Dev	1991 Nov	Wu F	-
22025453	Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.	Mol Carcinog	2012 Nov	Sand M	doi: 10.1002/mc.20861
7638159	Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat.	Proc Natl Acad Sci U S A	1995 Aug 1	Wu-Baer F	-
17151120	Adeno-associated virus site-specific integration is regulated by TRP-185.	J Virol	2007 Feb	Yamamoto N	-
7666565	A human chromosome 12-associated 83-kilodalton cellular protein specifically binds to the loop region of human immunodeficiency virus type 1 trans-activation response element RNA.	J Virol	1995 Oct	Hart CE	-
8626763	Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.	J Biol Chem	1996 Feb 23	Wu-Baer F	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496673	TARBP1-209	873	-	-	- (aa)	-	-
ENST00000463793	TARBP1-203	391	-	-	- (aa)	-	-
ENST00000484454	TARBP1-208	426	-	-	- (aa)	-	-
ENST00000483404	TARBP1-207	3082	-	-	- (aa)	-	-
ENST00000471918	TARBP1-205	457	-	-	- (aa)	-	-
ENST00000040877	TARBP1-201	5130	XM_005273234	ENSP00000040877	1621 (aa)	XP_005273291	Q13395
ENST00000462259	TARBP1-202	1650	-	-	- (aa)	-	-
ENST00000481183	TARBP1-206	535	-	-	- (aa)	-	-
ENST00000468077	TARBP1-204	514	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000059588's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000059588	Hip	1.37135479224574E-6	17903296
ENSG00000059588	Hip	1.1702363216042E-6	17903296
ENSG00000059588	Myocardial Infarction	6.6686645E-005	-
ENSG00000059588	Blood Urea Nitrogen	7.838e-005	-
ENSG00000059588	Platelet Function Tests	1.5372000E-005	-
ENSG00000059588	Platelet Function Tests	8.7090245E-006	-
ENSG00000059588	Platelet Function Tests	1.4049600E-005	-
ENSG00000059588	Platelet Function Tests	7.9376866E-006	-
ENSG00000059588	Immunoglobulins	4E-6	23382691
ENSG00000059588	Cholesterol, LDL	5E-6	21347282
ENSG00000059588	Neuropsychological Tests	6E-6	17903297
ENSG00000059588	Bipolar Disorder	5E-6	22688191

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000059588	rs10489896	1	234447872	?	Cognitive test performance	17903297			EFO_0003926

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000059588's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000059588	TARBP1	99	42.363	ENSAPOG00000016419	si:dkey-85a20.4	88	44.724	Acanthochromis_polyacanthus
ENSG00000059588	TARBP1	84	85.610	ENSAMEG00000003359	TARBP1	100	85.610	Ailuropoda_melanoleuca
ENSG00000059588	TARBP1	99	42.720	ENSATEG00000020266	si:dkey-85a20.4	88	45.219	Anabas_testudineus
ENSG00000059588	TARBP1	84	67.516	ENSAPLG00000007666	TARBP1	100	67.516	Anas_platyrhynchos
ENSG00000059588	TARBP1	99	58.733	ENSACAG00000001142	TARBP1	99	58.282	Anolis_carolinensis
ENSG00000059588	TARBP1	93	92.767	ENSANAG00000022031	TARBP1	100	87.415	Aotus_nancymaae
ENSG00000059588	TARBP1	99	84.337	ENSBTAG00000004517	TARBP1	99	84.644	Bos_taurus
ENSG00000059588	TARBP1	100	94.201	ENSCJAG00000018155	TARBP1	100	94.201	Callithrix_jacchus
ENSG00000059588	TARBP1	88	85.714	ENSCAFG00000011533	TARBP1	100	86.017	Canis_familiaris
ENSG00000059588	TARBP1	99	84.540	ENSCAFG00020027141	TARBP1	99	85.153	Canis_lupus_dingo
ENSG00000059588	TARBP1	99	83.190	ENSCHIG00000011437	TARBP1	99	83.929	Capra_hircus
ENSG00000059588	TARBP1	81	88.626	ENSTSYG00000010382	TARBP1	97	88.550	Carlito_syrichta
ENSG00000059588	TARBP1	79	69.201	ENSCAPG00000010831	TARBP1	99	69.044	Cavia_aperea
ENSG00000059588	TARBP1	99	75.926	ENSCPOG00000013995	TARBP1	99	76.543	Cavia_porcellus
ENSG00000059588	TARBP1	100	94.818	ENSCCAG00000037278	TARBP1	100	94.818	Cebus_capucinus
ENSG00000059588	TARBP1	100	96.854	ENSCATG00000011754	TARBP1	100	96.854	Cercocebus_atys
ENSG00000059588	TARBP1	83	80.000	ENSCLAG00000003655	TARBP1	99	80.000	Chinchilla_lanigera
ENSG00000059588	TARBP1	79	97.201	ENSCSAG00000010100	TARBP1	100	97.201	Chlorocebus_sabaeus
ENSG00000059588	TARBP1	95	66.151	ENSCPBG00000005587	TARBP1	99	68.335	Chrysemys_picta_bellii
ENSG00000059588	TARBP1	84	97.279	ENSCANG00000034343	TARBP1	100	97.279	Colobus_angolensis_palliatus
ENSG00000059588	TARBP1	99	75.062	ENSCGRG00001016690	Tarbp1	99	75.000	Cricetulus_griseus_chok1gshd
ENSG00000059588	TARBP1	98	76.780	ENSCGRG00000016893	Tarbp1	99	77.320	Cricetulus_griseus_crigri
ENSG00000059588	TARBP1	99	39.903	ENSCSEG00000005255	si:dkey-85a20.4	99	39.464	Cynoglossus_semilaevis
ENSG00000059588	TARBP1	85	45.996	ENSDARG00000079055	si:dkey-85a20.4	99	54.152	Danio_rerio
ENSG00000059588	TARBP1	99	83.756	ENSDNOG00000008637	TARBP1	99	83.635	Dasypus_novemcinctus
ENSG00000059588	TARBP1	80	74.383	ENSDORG00000007984	Tarbp1	100	74.383	Dipodomys_ordii
ENSG00000059588	TARBP1	99	87.931	ENSEASG00005000252	TARBP1	99	87.931	Equus_asinus_asinus
ENSG00000059588	TARBP1	99	87.931	ENSECAG00000023673	TARBP1	99	88.403	Equus_caballus
ENSG00000059588	TARBP1	85	44.657	ENSELUG00000012193	si:dkey-85a20.4	86	44.657	Esox_lucius
ENSG00000059588	TARBP1	99	83.374	ENSFCAG00000014183	TARBP1	99	83.436	Felis_catus
ENSG00000059588	TARBP1	80	68.865	ENSFALG00000013565	TARBP1	99	68.807	Ficedula_albicollis
ENSG00000059588	TARBP1	79	76.623	ENSFDAG00000001308	TARBP1	99	76.547	Fukomys_damarensis
ENSG00000059588	TARBP1	81	54.596	ENSFHEG00000007565	si:dkey-85a20.4	93	54.596	Fundulus_heteroclitus
ENSG00000059588	TARBP1	84	43.278	ENSGMOG00000004549	si:dkey-85a20.4	99	43.206	Gadus_morhua
ENSG00000059588	TARBP1	97	64.800	ENSGALG00000011000	TARBP1	100	64.600	Gallus_gallus
ENSG00000059588	TARBP1	99	41.551	ENSGAFG00000007387	si:dkey-85a20.4	85	44.483	Gambusia_affinis
ENSG00000059588	TARBP1	86	45.295	ENSGACG00000005865	si:dkey-85a20.4	99	45.263	Gasterosteus_aculeatus
ENSG00000059588	TARBP1	99	66.544	ENSGAGG00000012102	TARBP1	100	66.973	Gopherus_agassizii
ENSG00000059588	TARBP1	85	95.345	ENSGGOG00000022879	TARBP1	100	95.345	Gorilla_gorilla
ENSG00000059588	TARBP1	86	46.441	ENSHBUG00000008877	si:dkey-85a20.4	85	46.300	Haplochromis_burtoni
ENSG00000059588	TARBP1	99	78.629	ENSHGLG00000011592	TARBP1	99	78.691	Heterocephalus_glaber_female
ENSG00000059588	TARBP1	95	78.764	ENSHGLG00100015169	TARBP1	99	78.551	Heterocephalus_glaber_male
ENSG00000059588	TARBP1	99	40.423	ENSIPUG00000005249	si:dkey-85a20.4	84	43.500	Ictalurus_punctatus
ENSG00000059588	TARBP1	87	76.357	ENSSTOG00000032291	TARBP1	99	76.208	Ictidomys_tridecemlineatus
ENSG00000059588	TARBP1	93	73.875	ENSJJAG00000017840	Tarbp1	99	73.875	Jaculus_jaculus
ENSG00000059588	TARBP1	79	47.594	ENSKMAG00000017546	si:dkey-85a20.4	76	47.995	Kryptolebias_marmoratus
ENSG00000059588	TARBP1	65	50.536	ENSLBEG00000012132	si:dkey-85a20.4	74	50.536	Labrus_bergylta
ENSG00000059588	TARBP1	99	51.747	ENSLACG00000004337	TARBP1	99	51.294	Latimeria_chalumnae
ENSG00000059588	TARBP1	99	46.538	ENSLOCG00000016214	si:dkey-85a20.4	85	50.639	Lepisosteus_oculatus
ENSG00000059588	TARBP1	96	82.242	ENSLAFG00000011394	TARBP1	100	82.464	Loxodonta_africana
ENSG00000059588	TARBP1	100	92.976	ENSMFAG00000041068	TARBP1	100	93.038	Macaca_fascicularis
ENSG00000059588	TARBP1	100	93.846	ENSMMUG00000021703	TARBP1	100	94.092	Macaca_mulatta
ENSG00000059588	TARBP1	100	96.854	ENSMNEG00000045002	TARBP1	100	96.854	Macaca_nemestrina
ENSG00000059588	TARBP1	84	97.122	ENSMLEG00000044182	TARBP1	100	97.122	Mandrillus_leucophaeus
ENSG00000059588	TARBP1	95	44.182	ENSMAMG00000021760	si:dkey-85a20.4	89	45.517	Mastacembelus_armatus
ENSG00000059588	TARBP1	86	46.371	ENSMZEG00005005751	si:dkey-85a20.4	85	46.230	Maylandia_zebra
ENSG00000059588	TARBP1	99	74.227	ENSMAUG00000020968	Tarbp1	99	74.227	Mesocricetus_auratus
ENSG00000059588	TARBP1	99	79.926	ENSMICG00000015280	TARBP1	99	79.827	Microcebus_murinus
ENSG00000059588	TARBP1	99	73.700	ENSMOCG00000004128	Tarbp1	99	73.824	Microtus_ochrogaster
ENSG00000059588	TARBP1	99	41.269	ENSMMOG00000007795	si:dkey-85a20.4	88	43.418	Mola_mola
ENSG00000059588	TARBP1	99	72.607	ENSMODG00000008504	TARBP1	100	72.563	Monodelphis_domestica
ENSG00000059588	TARBP1	85	44.857	ENSMALG00000002916	si:dkey-85a20.4	85	44.882	Monopterus_albus
ENSG00000059588	TARBP1	99	72.727	MGP_CAROLIEiJ_G0031729	Tarbp1	99	72.789	Mus_caroli
ENSG00000059588	TARBP1	99	72.542	ENSMUSG00000090290	Tarbp1	99	72.604	Mus_musculus
ENSG00000059588	TARBP1	99	73.070	MGP_PahariEiJ_G0023326	Tarbp1	99	73.132	Mus_pahari
ENSG00000059588	TARBP1	99	72.626	MGP_SPRETEiJ_G0032846	Tarbp1	99	72.688	Mus_spretus
ENSG00000059588	TARBP1	77	83.736	ENSMPUG00000002802	TARBP1	99	83.655	Mustela_putorius_furo
ENSG00000059588	TARBP1	84	75.145	ENSMLUG00000002414	TARBP1	99	75.145	Myotis_lucifugus
ENSG00000059588	TARBP1	100	98.334	ENSNLEG00000002518	TARBP1	100	98.334	Nomascus_leucogenys
ENSG00000059588	TARBP1	69	77.542	ENSMEUG00000011370	-	69	77.542	Notamacropus_eugenii
ENSG00000059588	TARBP1	71	86.401	ENSOPRG00000013822	TARBP1	71	86.401	Ochotona_princeps
ENSG00000059588	TARBP1	99	73.564	ENSODEG00000005238	TARBP1	99	74.074	Octodon_degus
ENSG00000059588	TARBP1	86	46.127	ENSONIG00000009789	si:dkey-85a20.4	99	46.127	Oreochromis_niloticus
ENSG00000059588	TARBP1	100	85.530	ENSOCUG00000017418	TARBP1	99	85.406	Oryctolagus_cuniculus
ENSG00000059588	TARBP1	99	40.320	ENSORLG00000010529	si:dkey-85a20.4	88	42.721	Oryzias_latipes
ENSG00000059588	TARBP1	99	40.130	ENSORLG00020019264	si:dkey-85a20.4	88	42.449	Oryzias_latipes_hni
ENSG00000059588	TARBP1	99	40.393	ENSORLG00015003276	si:dkey-85a20.4	87	42.838	Oryzias_latipes_hsok
ENSG00000059588	TARBP1	99	84.701	ENSOGAG00000002379	TARBP1	100	84.454	Otolemur_garnettii
ENSG00000059588	TARBP1	91	89.130	ENSOARG00000003434	TARBP1	99	84.134	Ovis_aries
ENSG00000059588	TARBP1	84	98.973	ENSPPAG00000028097	TARBP1	100	98.973	Pan_paniscus
ENSG00000059588	TARBP1	95	88.889	ENSPPRG00000013561	TARBP1	99	75.535	Panthera_pardus
ENSG00000059588	TARBP1	83	86.012	ENSPTIG00000009281	TARBP1	99	86.012	Panthera_tigris_altaica
ENSG00000059588	TARBP1	100	98.829	ENSPTRG00000002124	TARBP1	100	98.829	Pan_troglodytes
ENSG00000059588	TARBP1	100	97.039	ENSPANG00000021933	TARBP1	100	97.039	Papio_anubis
ENSG00000059588	TARBP1	100	43.229	ENSPKIG00000016716	si:dkey-85a20.4	85	46.779	Paramormyrops_kingsleyae
ENSG00000059588	TARBP1	79	71.085	ENSPSIG00000010699	TARBP1	100	71.008	Pelodiscus_sinensis
ENSG00000059588	TARBP1	96	76.401	ENSPEMG00000006888	Tarbp1	99	77.231	Peromyscus_maniculatus_bairdii
ENSG00000059588	TARBP1	92	82.524	ENSPCIG00000029710	TARBP1	99	82.524	Phascolarctos_cinereus
ENSG00000059588	TARBP1	86	45.060	ENSPFOG00000013020	si:dkey-85a20.4	99	45.102	Poecilia_formosa
ENSG00000059588	TARBP1	99	41.855	ENSPLAG00000006044	si:dkey-85a20.4	85	45.028	Poecilia_latipinna
ENSG00000059588	TARBP1	99	42.026	ENSPMEG00000017857	si:dkey-85a20.4	85	44.958	Poecilia_mexicana
ENSG00000059588	TARBP1	93	43.425	ENSPREG00000022753	si:dkey-85a20.4	85	45.136	Poecilia_reticulata
ENSG00000059588	TARBP1	91	98.557	ENSPPYG00000000102	TARBP1	100	98.557	Pongo_abelii
ENSG00000059588	TARBP1	85	93.333	ENSPCAG00000004808	TARBP1	85	93.333	Procavia_capensis
ENSG00000059588	TARBP1	99	86.613	ENSPCOG00000005666	TARBP1	100	86.305	Propithecus_coquereli
ENSG00000059588	TARBP1	99	67.752	ENSPVAG00000014798	TARBP1	99	67.787	Pteropus_vampyrus
ENSG00000059588	TARBP1	86	45.184	ENSPNYG00000019135	si:dkey-85a20.4	85	44.801	Pundamilia_nyererei
ENSG00000059588	TARBP1	99	68.955	ENSRNOG00000053574	Tarbp1	99	68.646	Rattus_norvegicus
ENSG00000059588	TARBP1	98	90.262	ENSRBIG00000043362	TARBP1	100	90.618	Rhinopithecus_bieti
ENSG00000059588	TARBP1	100	92.597	ENSRROG00000029527	TARBP1	100	92.597	Rhinopithecus_roxellana
ENSG00000059588	TARBP1	91	93.424	ENSSBOG00000034503	TARBP1	100	93.424	Saimiri_boliviensis_boliviensis
ENSG00000059588	TARBP1	83	75.755	ENSSHAG00000000013	TARBP1	100	75.755	Sarcophilus_harrisii
ENSG00000059588	TARBP1	84	46.076	ENSSFOG00015002660	si:dkey-85a20.4	97	47.380	Scleropages_formosus
ENSG00000059588	TARBP1	91	44.183	ENSSMAG00000007081	si:dkey-85a20.4	88	44.983	Scophthalmus_maximus
ENSG00000059588	TARBP1	99	41.828	ENSSDUG00000023566	si:dkey-85a20.4	86	44.728	Seriola_dumerili
ENSG00000059588	TARBP1	99	43.276	ENSSLDG00000020200	si:dkey-85a20.4	86	46.499	Seriola_lalandi_dorsalis
ENSG00000059588	TARBP1	89	85.484	ENSSARG00000012207	TARBP1	89	85.484	Sorex_araneus
ENSG00000059588	TARBP1	99	64.954	ENSSPUG00000015364	TARBP1	100	64.832	Sphenodon_punctatus
ENSG00000059588	TARBP1	91	44.619	ENSSPAG00000007213	si:dkey-85a20.4	89	45.071	Stegastes_partitus
ENSG00000059588	TARBP1	99	85.477	ENSSSCG00000010160	TARBP1	99	85.392	Sus_scrofa
ENSG00000059588	TARBP1	80	68.931	ENSTGUG00000010214	TARBP1	100	68.931	Taeniopygia_guttata
ENSG00000059588	TARBP1	91	40.852	ENSTNIG00000016586	si:dkey-85a20.4	99	45.105	Tetraodon_nigroviridis
ENSG00000059588	TARBP1	91	83.295	ENSTTRG00000008707	TARBP1	96	83.295	Tursiops_truncatus
ENSG00000059588	TARBP1	82	85.166	ENSUMAG00000006730	TARBP1	99	85.166	Ursus_maritimus
ENSG00000059588	TARBP1	80	92.784	ENSVPAG00000007665	TARBP1	87	92.784	Vicugna_pacos
ENSG00000059588	TARBP1	85	86.127	ENSVVUG00000007460	TARBP1	97	86.055	Vulpes_vulpes
ENSG00000059588	TARBP1	84	56.423	ENSXETG00000016224	tarbp1	99	56.350	Xenopus_tropicalis
ENSG00000059588	TARBP1	78	48.704	ENSXCOG00000011779	si:dkey-85a20.4	93	48.704	Xiphophorus_couchianus
ENSG00000059588	TARBP1	65	43.494	ENSXMAG00000009600	si:dkey-85a20.4	100	43.123	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0005634	nucleus	8846792.	TAS	Component
GO:0006357	regulation of transcription by RNA polymerase II	8846792.	TAS	Process
GO:0016423	tRNA (guanine) methyltransferase activity	21873635.	IBA	Function
GO:0030488	tRNA methylation	21873635.	IBA	Process

EuRBPDB

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Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.