EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	857226	Nonsense_Mutation	novel	C459*	0.2
BLCA	chr12	753929	Missense_Mutation	novel	E122K	0.42
BLCA	chr12	861034	Missense_Mutation	novel	E548Q	0.32
BLCA	chr12	896524	Missense_Mutation	novel	D2013N	0.35
BLCA	chr12	827130	Missense_Mutation	NA	R341G	0.07
BLCA	chr12	887252	Missense_Mutation	rs770566791	G1771A	0.79
BLCA	chr12	753785	Missense_Mutation	novel	T74A	0.23
BLCA	chr12	881725	Missense_Mutation	novel	E1049Q	0.13
BLCA	chr12	867890	Intron	novel		0.23
BLCA	chr12	753629	Missense_Mutation	NA	A22S	0.34
BLCA	chr12	894620	Silent	novel	K1856K	0.44
BLCA	chr12	879816	Silent	rs776249622	L873L	0.32
BLCA	chr12	908601	Missense_Mutation	rs144574284	M2320V	0.65
BLCA	chr12	896524	Missense_Mutation	novel	D2013H	0.06
BLCA	chr12	885404	Missense_Mutation	NA	H1534D	0.12
BLCA	chr12	861066	Missense_Mutation	novel	I558M	0.12
BLCA	chr12	879711	Missense_Mutation	novel	Q838E	0.16
BLCA	chr12	897544	Missense_Mutation	novel	K2104T	0.31
BLCA	chr12	885397	Missense_Mutation	novel	K1531N	0.21
BLCA	chr12	851767	Intron	novel		0.47
BLCA	chr12	879629	Silent	rs201913428	A810A	0.37
BLCA	chr12	896417	Missense_Mutation	NA	A1977V	0.38
BLCA	chr12	827154	Missense_Mutation	NA	D349N	0.23
BLCA	chr12	868868	Intron	novel		0.14
BLCA	chr12	884711	Missense_Mutation	novel	L1303I	0.42
BLCA	chr12	896240	Missense_Mutation	novel	S1918F	0.19
BLCA	chr12	896388	Silent	novel	I1967I	0.3
BLCA	chr12	813708	Nonsense_Mutation	novel	Q276*	0.18
BLCA	chr12	896619	Missense_Mutation	NA	Q2044H	0.24
BLCA	chr12	871317	Missense_Mutation	NA	S731L	0.43
BLCA	chr12	830142	Silent	novel	I431I	0.39
BLCA	chr12	861150	Missense_Mutation	novel	E586D	0.4
BLCA	chr12	827130	Missense_Mutation	NA	R341G	0.45
BLCA	chr12	868816	Intron	novel		0.23
BLCA	chr12	868376	Intron	novel		0.45
BLCA	chr12	879951	Missense_Mutation	NA	A918S	0.5
BLCA	chr12	884998	Silent	NA	L1398L	0.47
BRCA	chr12	881710	Nonsense_Mutation	novel	Q1044*	0.29
BRCA	chr12	868518	Intron	novel		0.42
BRCA	chr12	883061	Splice_Site	NA	X1163_splice	0.32
BRCA	chr12	896417	Missense_Mutation	NA	A1977V	0.39
BRCA	chr12	887296	Missense_Mutation	NA	L1786V	0.07
BRCA	chr12	884809	Silent	novel	V1335V	0.04
BRCA	chr12	885276	Missense_Mutation	rs770856927	S1491L	0.14
BRCA	chr12	868344	Intron	rs747566114		0.27
BRCA	chr12	884189	Missense_Mutation	novel	P1264S	0.34
BRCA	chr12	878266	Missense_Mutation	novel	S760P	0.04
BRCA	chr12	861159	Silent	novel	L589L	0.28
BRCA	chr12	827230	Missense_Mutation	novel	L374Q	0.21
BRCA	chr12	884666	Nonsense_Mutation	novel	Q1288*	0.09
BRCA	chr12	868928	Intron	novel		0.09
BRCA	chr12	900528	Silent	NA	L2167L	0.23
BRCA	chr12	827258	Silent	NA	V383V	0.27
BRCA	chr12	830011	Missense_Mutation	NA	E388Q	0.36
BRCA	chr12	896121	Missense_Mutation	NA	E1878D	0.18
BRCA	chr12	897642	Nonsense_Mutation	NA	R2137*	0.13
BRCA	chr12	868005	Intron	NA		0.4
BRCA	chr12	885531	Missense_Mutation	rs769323756	I1576T	0.24
BRCA	chr12	867981	Intron	novel		0.16
BRCA	chr12	879816	Silent	rs776249622	L873L	0.13
CESC	chr12	907997	Missense_Mutation	NA	S2265L	0.11
CESC	chr12	861327	Silent	rs771833169	P645P	0.13
CESC	chr12	830050	Missense_Mutation	novel	E401K	0.36
CESC	chr12	861148	Missense_Mutation	NA	E586K	0.24
CESC	chr12	868755	Intron	novel		0.17
CESC	chr12	884670	Missense_Mutation	novel	S1289N	0.63
CESC	chr12	862143	Missense_Mutation	novel	S671I	0.11
CESC	chr12	896692	Missense_Mutation	novel	D2069N	0.46
CESC	chr12	830117	Missense_Mutation	NA	S423L	0.43
CESC	chr12	867938	Intron	NA		0.23
CESC	chr12	885450	Missense_Mutation	NA	S1549F	0.2
CESC	chr12	883512	Missense_Mutation	NA	D1203N	0.47
CESC	chr12	867944	Intron	NA		0.42
CESC	chr12	868891	Intron	NA		0.35
CESC	chr12	896361	Missense_Mutation	NA	F1958L	0.47
CHOL	chr12	878280	Frame_Shift_Ins	novel	*S765Wfs4**	0.18
CHOL	chr12	857201	Missense_Mutation	novel	E451G	0.38
COAD	chr12	753879	Missense_Mutation	NA	P105H	0.29
COAD	chr12	897532	Missense_Mutation	NA	S2100Y	0.35
COAD	chr12	830151	Silent	rs201053384	R434R	0.03
COAD	chr12	868761	Intron	rs751535403		0.18
COAD	chr12	861185	Missense_Mutation	novel	A598V	0.13
COAD	chr12	753574	Silent	NA	G3G	0.38
COAD	chr12	754272	Missense_Mutation	rs774337782	Y236F	0.33
COAD	chr12	868069	Intron	rs746562703		0.38
COAD	chr12	813730	Frame_Shift_Del	NA	*F283Lfs8**	0.19
COAD	chr12	885489	Missense_Mutation	NA	S1562Y	0.23
COAD	chr12	868430	Intron	novel		0.04
COAD	chr12	868675	Intron	NA		0.47
COAD	chr12	879686	Silent	novel	Q829Q	0.16
COAD	chr12	868578	Intron	rs187534119		0.13
COAD	chr12	882961	Nonsense_Mutation	NA	R1131*	0.12
COAD	chr12	869511	Intron	NA		0.32
COAD	chr12	753635	Frame_Shift_Ins	NA	*K26Qfs51**	0.42
COAD	chr12	857165	Missense_Mutation	novel	V439A	0.48
COAD	chr12	884864	Missense_Mutation	NA	A1354T	0.31
COAD	chr12	908631	Missense_Mutation	NA	A2330T	0.43
COAD	chr12	827092	Missense_Mutation	NA	C328Y	0.19
COAD	chr12	885493	Silent	NA	Q1563Q	0.44
COAD	chr12	859358	Missense_Mutation	novel	R505H	0.35
COAD	chr12	896592	Missense_Mutation	NA	Q2035H	0.32
COAD	chr12	867944	Intron	NA		0.31
COAD	chr12	827252	Silent	NA	K381K	0.12
COAD	chr12	908853	3'UTR	novel		0.32
COAD	chr12	885275	Missense_Mutation	novel	S1491P	0.08
COAD	chr12	830145	Silent	NA	Y432Y	0.28
COAD	chr12	859434	Silent	NA	R530R	0.22
COAD	chr12	867982	Intron	NA		0.24
COAD	chr12	868254	Intron	rs375482581		0.12
COAD	chr12	868869	Intron	novel		0.2
COAD	chr12	879593	Silent	NA	V798V	0.14
COAD	chr12	885627	Missense_Mutation	rs781667314	A1608V	0.35
COAD	chr12	859391	Missense_Mutation	NA	Y516C	0.23
COAD	chr12	885242	Missense_Mutation	NA	A1480T	0.29
COAD	chr12	900650	Missense_Mutation	NA	S2208N	0.19
COAD	chr12	830117	Missense_Mutation	NA	S423L	0.37
COAD	chr12	867944	Intron	NA		0.34
COAD	chr12	879907	Missense_Mutation	novel	V903A	0.36
COAD	chr12	896393	Missense_Mutation	NA	D1969G	0.32
COAD	chr12	885271	Silent	NA	L1489L	0.24
ESCA	chr12	885738	Missense_Mutation	novel	K1645R	0.3
ESCA	chr12	868594	Intron	novel		0.21
GBM	chr12	880006	Missense_Mutation	novel	L936H	0.06
GBM	chr12	885513	Nonsense_Mutation	novel	L1570*	0.08
GBM	chr12	889216	Missense_Mutation	NA	A1814V	0.31
GBM	chr12	830091	Missense_Mutation	novel	E414D	0.22
GBM	chr12	857209	Missense_Mutation	novel	E454K	0.18
GBM	chr12	861030	Silent	novel	V546V	0.35
GBM	chr12	896178	Missense_Mutation	novel	S1897R	0.09
GBM	chr12	896716	Nonsense_Mutation	novel	R2077*	0.39
GBM	chr12	896719	Silent	novel	R2078R	0.17
HNSC	chr12	881762	Missense_Mutation	rs756270744	P1061L	0.18
HNSC	chr12	885457	Silent	novel	S1551S	0.24
HNSC	chr12	887268	In_Frame_Ins	novel	Q1777_S1785dup	0.06
HNSC	chr12	885522	Missense_Mutation	novel	P1573Q	0.37
HNSC	chr12	885420	Missense_Mutation	novel	G1539A	0.2
HNSC	chr12	887257	Silent	novel	L1773L	0.14
HNSC	chr12	868218	Intron	rs749154375		0.41
HNSC	chr12	830109	Silent	novel	Y420Y	0.05
HNSC	chr12	896127	Silent	novel	A1880A	0.11
HNSC	chr12	879816	Silent	rs776249622	L873L	0.19
HNSC	chr12	869082	Intron	novel		0.12
HNSC	chr12	827093	Missense_Mutation	novel	C328W	0.08
HNSC	chr12	851744	Intron	novel		0.15
HNSC	chr12	861171	Silent	rs772544134	V593V	0.23
HNSC	chr12	879850	Missense_Mutation	rs759393178	A884V	0.22
HNSC	chr12	879658	Missense_Mutation	rs74056058	S820C	0.1
HNSC	chr12	867981	Intron	rs775154028		0.35
HNSC	chr12	885477	Missense_Mutation	novel	S1558C	0.18
HNSC	chr12	851716	Intron	novel		0.24
HNSC	chr12	884754	Missense_Mutation	novel	E1317G	0.34
HNSC	chr12	884161	Silent	novel	A1254A	0.31
HNSC	chr12	868740	Intron	novel		0.05
KIRC	chr12	753567	Translation_Start_Site	NA	M1?	0.25
KIRC	chr12	868182	Intron	NA		0.34
KIRC	chr12	884703	Missense_Mutation	NA	S1300C	0.27
KIRC	chr12	827185	Missense_Mutation	NA	G359A	0.18
KIRC	chr12	879679	Missense_Mutation	novel	V827G	0.05
KIRP	chr12	869022	Intron	NA		0.16
KIRP	chr12	907955	Missense_Mutation	novel	H2251P	0.34
KIRP	chr12	859464	Missense_Mutation	novel	M540I	0.39
KIRP	chr12	879695	Silent	novel	P832P	0.59
KIRP	chr12	908663	Silent	novel	T2340T	0.17
KIRP	chr12	896085	Silent	novel	A1866A	0.38
LAML	chr12	861075	Missense_Mutation	NA	R561S	0.43
LGG	chr12	885216	Missense_Mutation	NA	P1471L	0.27
LGG	chr12	868940	Intron	novel		0.21
LGG	chr12	827284	Intron	novel		0.08
LGG	chr12	851768	Intron	novel		0.33
LGG	chr12	880730	Missense_Mutation	NA	P948S	0.03
LIHC	chr12	813769	Missense_Mutation	novel	C296Y	0.16
LIHC	chr12	900549	Silent	NA	P2174P	0.43
LIHC	chr12	869149	Intron	novel		0.32
LIHC	chr12	882981	Missense_Mutation	novel	L1137F	0.18
LUAD	chr12	754044	Missense_Mutation	novel	T160N	0.25
LUAD	chr12	861066	Silent	novel	I558I	0.28
LUAD	chr12	882049	Silent	novel	S1116S	0.26
LUAD	chr12	871286	Nonsense_Mutation	novel	Q721*	0.42
LUAD	chr12	885175	Silent	novel	S1457S	0.12
LUAD	chr12	868988	Intron	novel		0.07
LUAD	chr12	880004	Silent	rs555482187	P935P	0.22
LUAD	chr12	880866	Missense_Mutation	novel	T993K	0.14
LUAD	chr12	861035	Missense_Mutation	novel	E548V	0.57
LUAD	chr12	900603	Missense_Mutation	NA	D2192E	0.07
LUAD	chr12	859358	Missense_Mutation	NA	R505L	0.16
LUAD	chr12	861090	Missense_Mutation	rs766215765	K566N	0.2
LUAD	chr12	827172	Missense_Mutation	rs753222480	I355V	0.24
LUAD	chr12	897675	Missense_Mutation	NA	L2148F	0.1
LUAD	chr12	868005	Intron	NA		0.19
LUAD	chr12	868832	Intron	NA		0.76
LUAD	chr12	879896	Frame_Shift_Del	novel	*L900Afs27**	0.06
LUAD	chr12	861040	Missense_Mutation	NA	D550H	0.07
LUAD	chr12	896169	Silent	NA	V1894V	0.39
LUAD	chr12	859328	Missense_Mutation	novel	G495V	0.13
LUAD	chr12	830147	Missense_Mutation	novel	R433L	0.4
LUAD	chr12	885021	Missense_Mutation	NA	S1406L	0.25
LUAD	chr12	867864	Intron	NA		0.33
LUAD	chr12	884825	Missense_Mutation	novel	S1341R	0.1
LUAD	chr12	884799	Missense_Mutation	NA	T1332I	0.1
LUAD	chr12	885610	Silent	NA	P1602P	0.23
LUAD	chr12	879628	Missense_Mutation	rs770002621	A810V	0.23
LUAD	chr12	900522	Missense_Mutation	novel	Q2165H	0.12
LUAD	chr12	871263	Splice_Site	novel	X714_splice	0.11
LUAD	chr12	880907	Missense_Mutation	rs191295023	M1007V	0.14
LUAD	chr12	868115	Intron	novel		0.05
LUSC	chr12	885135	Missense_Mutation	novel	S1444N	0.13
LUSC	chr12	896510	Missense_Mutation	NA	N2008S	0.32
LUSC	chr12	885857	Missense_Mutation	novel	E1685K	0.55
LUSC	chr12	884157	Missense_Mutation	NA	S1253F	0.1
LUSC	chr12	879748	Missense_Mutation	NA	H850R	0.47
LUSC	chr12	896426	Missense_Mutation	NA	P1980R	0.56
LUSC	chr12	882027	Missense_Mutation	novel	R1109L	0.23
LUSC	chr12	880721	Missense_Mutation	novel	G945C	0.08
LUSC	chr12	830123	Missense_Mutation	novel	C425S	0.07
LUSC	chr12	881932	Silent	NA	S1077S	0.18
LUSC	chr12	896190	Missense_Mutation	NA	E1901D	0.13
LUSC	chr12	868671	Intron	NA		0.09
LUSC	chr12	885453	Missense_Mutation	NA	S1550C	0.49
LUSC	chr12	884755	Silent	novel	E1317E	0.09
LUSC	chr12	879927	Missense_Mutation	novel	V910F	0.16
LUSC	chr12	885634	Silent	NA	V1610V	0.34
LUSC	chr12	754022	Missense_Mutation	NA	P153S	0.24
LUSC	chr12	753807	Missense_Mutation	NA	R81P	0.25
LUSC	chr12	753863	Missense_Mutation	NA	L100V	0.23
LUSC	chr12	881773	Missense_Mutation	NA	A1065T	0.21
LUSC	chr12	884789	Missense_Mutation	rs764193532	T1329A	0.57
LUSC	chr12	868520	Intron	novel		0.34
LUSC	chr12	754080	Missense_Mutation	NA	V172E	0.59
LUSC	chr12	868475	Intron	novel		0.2
LUSC	chr12	883506	Missense_Mutation	NA	E1201Q	0.16
LUSC	chr12	896202	Silent	NA	V1905V	0.22
LUSC	chr12	884192	Missense_Mutation	NA	E1265K	0.07
LUSC	chr12	885867	Missense_Mutation	novel	V1688A	0.36
LUSC	chr12	868176	Intron	NA		0.36
LUSC	chr12	859400	Missense_Mutation	novel	N519S	0.42
LUSC	chr12	868271	Intron	NA		0.57
LUSC	chr12	908735	Silent	NA	I2364I	0.38
LUSC	chr12	896089	Missense_Mutation	novel	G1868R	0.72
LUSC	chr12	754110	Missense_Mutation	novel	R182T	0.1
LUSC	chr12	868116	Intron	novel		0.2
LUSC	chr12	830110	Missense_Mutation	novel	P421A	0.15
LUSC	chr12	907903	Nonsense_Mutation	novel	Q2234*	0.2
LUSC	chr12	896326	Nonsense_Mutation	NA	Q1947*	0.05
OV	chr12	827124	Missense_Mutation	novel	H339Y	0.03
OV	chr12	827148	Missense_Mutation	novel	H347N	0.07
OV	chr12	884856	Missense_Mutation	NA	A1351V	0.13
OV	chr12	896621	Missense_Mutation	NA	N2045T	0.16
OV	chr12	908786	Silent	rs369472011	T2381T	0.18
OV	chr12	868663	Intron	NA		0.21
OV	chr12	896383	Missense_Mutation	NA	K1966E	0.27
OV	chr12	827192	Frame_Shift_Del	novel	*G362Afs13**	0.21
OV	chr12	879808	Missense_Mutation	NA	T870I	0.25
OV	chr12	862093	Silent	rs778958438	T654T	0.22
OV	chr12	879608	Silent	NA	G803G	0.66
OV	chr12	827089	Missense_Mutation	novel	W327L	0.06
OV	chr12	885870	Missense_Mutation	novel	T1689R	0.06
OV	chr12	908798	3'UTR	novel		0.29
OV	chr12	830115	Silent	rs780974617	Y422Y	0.43
OV	chr12	896645	Missense_Mutation	novel	S2053L	0.04
PAAD	chr12	878227	Nonsense_Mutation	novel	Q747*	0.13
PRAD	chr12	754203	Missense_Mutation	NA	G213E	0.11
PRAD	chr12	885389	Missense_Mutation	novel	L1529V	0.27
PRAD	chr12	753883	Frame_Shift_Del	novel	*I107Tfs6**	0.38
PRAD	chr12	857218	Missense_Mutation	NA	E457K	0.46
PRAD	chr12	908762	Frame_Shift_Del	NA	*P2375Qfs15**	0.33
PRAD	chr12	830150	Missense_Mutation	novel	R434H	0.2
READ	chr12	859418	Missense_Mutation	NA	S525Y	0.37
READ	chr12	896395	Missense_Mutation	NA	T1970P	0.27
READ	chr12	868407	Intron	NA		0.38
READ	chr12	827131	Missense_Mutation	NA	R341Q	0.08
READ	chr12	868698	Intron	novel		0.13
READ	chr12	868575	Intron	NA		0.41
READ	chr12	894568	Missense_Mutation	NA	Q1839P	0.13
READ	chr12	896689	Missense_Mutation	NA	E2068K	0.21
SARC	chr12	900525	Silent	novel	T2166T	0.45
SARC	chr12	896211	Missense_Mutation	novel	E1908D	0.12
SARC	chr12	907912	Missense_Mutation	novel	A2237P	0.09
SKCM	chr12	885880	Silent	NA	I1692I	0.3
SKCM	chr12	896534	Missense_Mutation	NA	A2016V	0.31
SKCM	chr12	908752	Missense_Mutation	novel	S2370F	0.55
SKCM	chr12	883413	Silent	NA	L1170L	0.18
SKCM	chr12	885621	Missense_Mutation	novel	P1606L	0.37
SKCM	chr12	884761	Silent	NA	P1319P	0.29
SKCM	chr12	885434	Missense_Mutation	NA	L1544F	0.21
SKCM	chr12	885793	Silent	NA	F1663F	0.26
SKCM	chr12	896536	Missense_Mutation	rs543902824	A2017T	0.23
SKCM	chr12	830022	Silent	NA	A391A	0.22
SKCM	chr12	880895	Missense_Mutation	rs777505065	L1003F	0.28
SKCM	chr12	885038	Missense_Mutation	novel	V1412L	0.47
SKCM	chr12	869032	Intron	NA		0.12
SKCM	chr12	879688	Missense_Mutation	rs575889688	P830L	0.44
SKCM	chr12	885231	Missense_Mutation	NA	S1476F	0.36
SKCM	chr12	871317	Missense_Mutation	NA	S731L	0.09
SKCM	chr12	885457	Silent	NA	S1551S	0.13
SKCM	chr12	885605	Missense_Mutation	NA	P1601S	0.15
SKCM	chr12	879671	Silent	novel	F824F	0.18
SKCM	chr12	862205	Missense_Mutation	NA	G692R	0.35
SKCM	chr12	868624	Intron	NA		0.47
SKCM	chr12	868626	Intron	NA		0.46
SKCM	chr12	881766	Silent	NA	T1062T	0.31
SKCM	chr12	869183	Intron	novel		0.18
SKCM	chr12	896229	Silent	NA	I1914I	0.18
SKCM	chr12	869183	Intron	novel		0.35
SKCM	chr12	885686	Missense_Mutation	novel	P1628S	0.31
SKCM	chr12	885687	Missense_Mutation	novel	P1628L	0.32
SKCM	chr12	880872	Missense_Mutation	novel	V995G	0.33
SKCM	chr12	896356	Missense_Mutation	rs201766777	R1957C	0.7
SKCM	chr12	862242	Missense_Mutation	NA	P704L	0.43
SKCM	chr12	869096	Intron	NA		0.09
SKCM	chr12	896472	Silent	NA	K1995K	0.15
SKCM	chr12	868884	Intron	NA		0.57
SKCM	chr12	878239	Missense_Mutation	novel	P751S	0.43
SKCM	chr12	859350	Silent	rs756183529	L502L	0.43
SKCM	chr12	827102	Silent	novel	I331I	0.19
SKCM	chr12	869033	Intron	NA		0.24
SKCM	chr12	879854	Silent	rs754117969	I885I	0.47
SKCM	chr12	859278	Silent	rs61736906	F478F	0.18
SKCM	chr12	868158	Intron	novel		0.41
SKCM	chr12	897542	Silent	NA	T2103T	0.16
SKCM	chr12	880824	Missense_Mutation	NA	P979L	0.07
SKCM	chr12	885294	Missense_Mutation	NA	S1497L	0.41
SKCM	chr12	879584	Silent	novel	S795S	0.33
SKCM	chr12	880939	Silent	novel	S1017S	0.59
SKCM	chr12	879671	Silent	novel	F824F	0.27
STAD	chr12	884199	Missense_Mutation	NA	R1267L	0.34
STAD	chr12	830095	Missense_Mutation	NA	A416T	0.21
STAD	chr12	827177	Silent	novel	F356F	0.26
STAD	chr12	885055	Silent	rs766701999	T1417T	0.08
STAD	chr12	896132	Missense_Mutation	NA	S1882F	0.1
STAD	chr12	885137	Missense_Mutation	rs535135770	T1445A	0.04
STAD	chr12	827255	Silent	novel	S382S	0.21
STAD	chr12	885736	Frame_Shift_Ins	novel	*A1646Sfs5**	0.1
STAD	chr12	859331	Frame_Shift_Del	novel	I498*	0.36
STAD	chr12	908762	Frame_Shift_Del	NA	*P2375Qfs15**	0.12
STAD	chr12	886032	Missense_Mutation	NA	S1743L	0.17
STAD	chr12	753750	Missense_Mutation	NA	D62G	0.27
STAD	chr12	859322	Missense_Mutation	NA	D493G	0.06
STAD	chr12	885508	Missense_Mutation	NA	H1568Q	0.09
STAD	chr12	894632	Silent	NA	F1860F	0.22
STAD	chr12	897511	Missense_Mutation	rs200315094	R2093H	0.12
STAD	chr12	900519	Silent	NA	Q2164Q	0.29
STAD	chr12	883809	Silent	rs147752204	A1233A	0.26
STAD	chr12	896357	Missense_Mutation	rs36083875	R1957H	0.5
STAD	chr12	896261	Missense_Mutation	NA	A1925V	0.05
STAD	chr12	880893	Missense_Mutation	NA	N1002S	0.21
STAD	chr12	896403	Missense_Mutation	NA	K1972N	0.21
STAD	chr12	897522	Missense_Mutation	novel	E2097K	0.28
STAD	chr12	879757	Frame_Shift_Ins	novel	*A854Gfs51**	0.54
STAD	chr12	896261	Missense_Mutation	NA	A1925V	0.2
STAD	chr12	830040	Silent	NA	E397E	0.05
STAD	chr12	885530	Missense_Mutation	novel	I1576V	0.3
STAD	chr12	859274	Missense_Mutation	novel	A477V	0.2
STAD	chr12	908761	Frame_Shift_Ins	novel	*G2376Rfs16**	0.17
STAD	chr12	896213	Missense_Mutation	rs548442202	P1909L	0.28
STAD	chr12	813746	Missense_Mutation	NA	E288D	0.17
STAD	chr12	879851	Silent	NA	A884A	0.23
STAD	chr12	879648	Missense_Mutation	novel	P817T	0.3
STAD	chr12	883515	Nonsense_Mutation	NA	Q1204*	0.33
STAD	chr12	896689	Missense_Mutation	NA	E2068K	0.13
STAD	chr12	868549	Intron	novel		0.17
STAD	chr12	857228	Missense_Mutation	NA	I460T	0.29
TGCT	chr12	885142	Silent	NA	A1446A	0.25
TGCT	chr12	859261	Missense_Mutation	novel	L473F	0.08
THCA	chr12	896175	Nonsense_Mutation	novel	*S1897Qfs4**	0.12
UCEC	chr12	813811	Missense_Mutation	NA	K310R	0.32
UCEC	chr12	885124	Silent	rs72650730	I1440I	0.32
UCEC	chr12	885231	Missense_Mutation	NA	S1476Y	0.33
UCEC	chr12	885372	Missense_Mutation	NA	V1523A	0.42
UCEC	chr12	896108	Missense_Mutation	NA	K1874R	0.3
UCEC	chr12	859320	Missense_Mutation	NA	E492D	0.25
UCEC	chr12	885364	Silent	NA	E1520E	0.31
UCEC	chr12	827153	Silent	rs201400797	R348R	0.13
UCEC	chr12	868004	Intron	rs200794710		0.13
UCEC	chr12	868174	Intron	novel		0.15
UCEC	chr12	754241	Nonsense_Mutation	NA	E226*	0.22
UCEC	chr12	868703	Intron	novel		0.33
UCEC	chr12	867911	Intron	novel		0.11
UCEC	chr12	879643	Missense_Mutation	novel	V815A	0.18
UCEC	chr12	879891	Missense_Mutation	rs777908830	T898A	0.35
UCEC	chr12	884120	Splice_Site	novel	X1241_splice	0.29
UCEC	chr12	896089	Missense_Mutation	rs766436838	G1868S	0.38
UCEC	chr12	884225	Splice_Site	novel	X1276_splice	0.27
UCEC	chr12	885503	Silent	novel	L1567L	0.09
UCEC	chr12	827488	Intron	novel		0.5
UCEC	chr12	861179	Missense_Mutation	rs144114167	S596F	0.38
UCEC	chr12	879573	Missense_Mutation	novel	L792I	0.51
UCEC	chr12	900650	Missense_Mutation	novel	S2208I	0.36
UCEC	chr12	907950	Silent	novel	D2249D	0.33
UCEC	chr12	868700	Intron	novel		0.35
UCEC	chr12	880831	Silent	rs72650706	P981P	0.41
UCEC	chr12	868797	Intron	novel		0.12
UCEC	chr12	908498	Silent	novel	F2285F	0.14
UCEC	chr12	813755	Silent	NA	V291V	0.21
UCEC	chr12	885702	Missense_Mutation	NA	T1633I	0.2
UCEC	chr12	900536	Missense_Mutation	NA	P2170H	0.11
UCEC	chr12	869035	Intron	NA		0.06
UCEC	chr12	896400	Silent	NA	K1971K	0.38
UCEC	chr12	861227	Missense_Mutation	NA	G612D	0.26
UCEC	chr12	885121	Missense_Mutation	novel	E1439D	0.11
UCEC	chr12	885859	Silent	NA	E1685E	0.17
UCEC	chr12	879948	Missense_Mutation	novel	P917T	0.17
UCEC	chr12	896634	Silent	novel	S2049S	0.15
UCEC	chr12	861340	Silent	NA	L650L	0.44
UCEC	chr12	900561	Silent	NA	Q2178Q	0.37
UCEC	chr12	868251	Intron	novel		0.24
UCEC	chr12	884136	Missense_Mutation	novel	S1246Y	0.43
UCEC	chr12	881999	Missense_Mutation	rs750612826	R1100W	0.22
UCEC	chr12	868615	Intron	NA		0.49
UCEC	chr12	868698	Intron	novel		0.1
UCEC	chr12	857230	Nonsense_Mutation	novel	R461*	0.41
UCEC	chr12	868284	Intron	novel		0.13
UCEC	chr12	884160	Missense_Mutation	NA	A1254V	0.26
UCEC	chr12	862083	Missense_Mutation	novel	S651F	0.32
UCEC	chr12	867794	Intron	novel		0.14
UCEC	chr12	880829	Missense_Mutation	novel	P981S	0.28
UCEC	chr12	868121	Intron	rs764190549		0.37
UCEC	chr12	884903	Missense_Mutation	novel	S1367P	0.4
UCEC	chr12	868278	Intron	novel		0.35
UCEC	chr12	861217	Missense_Mutation	novel	A609T	0.09
UCEC	chr12	908576	Silent	NA	T2311T	0.27
UCEC	chr12	869149	Intron	novel		0.32
UCEC	chr12	851742	Intron	novel		0.43
UCEC	chr12	896688	Silent	novel	I2067I	0.5
UCEC	chr12	827131	Missense_Mutation	NA	R341Q	0.23
UCEC	chr12	884702	Missense_Mutation	novel	S1300P	0.25
UCEC	chr12	896569	Missense_Mutation	novel	G2028S	0.43
UCEC	chr12	813661	Missense_Mutation	novel	S260Y	0.45
UCEC	chr12	827235	Missense_Mutation	novel	R376W	0.55
UCEC	chr12	851742	Intron	novel		0.37
UCEC	chr12	908762	Frame_Shift_Del	NA	*P2375Qfs15**	0.34
UCEC	chr12	859374	Silent	NA	K510K	0.21
UCEC	chr12	890494	Silent	NA	G1830G	0.37
UCEC	chr12	896319	Silent	NA	G1944G	0.15
UCEC	chr12	813681	Nonsense_Mutation	novel	E267*	0.28
UCEC	chr12	857228	Missense_Mutation	NA	I460T	0.29
UCEC	chr12	859410	Silent	novel	I522I	0.28
UCEC	chr12	861296	Missense_Mutation	novel	D635V	0.4
UCEC	chr12	908477	Splice_Region	novel	G2278G	0.29
UCEC	chr12	859346	Missense_Mutation	novel	K501T	0.44
UCEC	chr12	868462	Intron	novel		0.12
UCEC	chr12	827153	Silent	rs201400797	R348R	0.55
UCEC	chr12	830056	Missense_Mutation	rs72648631	V403I	0.48
UCEC	chr12	868364	Intron	novel		0.35
UCEC	chr12	885733	Silent	rs775443497	Q1643Q	0.3
UCEC	chr12	879765	Missense_Mutation	novel	T856A	0.28
UCEC	chr12	883453	Missense_Mutation	novel	E1183A	0.41
UCEC	chr12	907879	Missense_Mutation	novel	V2226M	0.28
UCEC	chr12	859261	Missense_Mutation	novel	L473I	0.3
UCEC	chr12	861019	Missense_Mutation	novel	S543P	0.28
UCEC	chr12	862127	Nonsense_Mutation	novel	E666*	0.42
UCEC	chr12	868004	Intron	rs200794710		0.47
UCEC	chr12	883466	Silent	NA	K1187K	0.33
UCEC	chr12	885338	Missense_Mutation	NA	S1512R	0.27
UCEC	chr12	897667	Missense_Mutation	novel	S2145N	0.19
UCEC	chr12	830139	Silent	novel	Q430Q	0.33
UCEC	chr12	883786	Nonsense_Mutation	novel	E1226*	0.23
UCEC	chr12	885026	Missense_Mutation	novel	V1408L	0.23
UCEC	chr12	830062	Missense_Mutation	NA	V405I	0.2
UCEC	chr12	880023	Missense_Mutation	NA	L942M	0.37
UCEC	chr12	885009	Missense_Mutation	NA	P1402H	0.28
UCEC	chr12	887220	In_Frame_Ins	novel	G1765_T1766insAVPGFTPDVVVLPVG	0.02
UCEC	chr12	886005	Missense_Mutation	NA	V1734A	0.15
UCEC	chr12	868004	Intron	rs200794710		0.45
UCEC	chr12	827266	Splice_Region	novel		0.2
UCEC	chr12	830076	Silent	novel	G409G	0.09
UCEC	chr12	868375	Intron	novel		0.47
UCEC	chr12	813689	Silent	rs770446632	A269A	0.3
UCEC	chr12	878233	Missense_Mutation	NA	A749S	0.43
UCEC	chr12	881940	Missense_Mutation	NA	S1080N	0.39
UCEC	chr12	885403	Silent	novel	S1533S	0.46
UCEC	chr12	885269	Missense_Mutation	novel	L1489I	0.14
UCEC	chr12	896088	Silent	rs763160743	D1867D	0.25
UCEC	chr12	883525	Missense_Mutation	novel	E1207G	0.01
UCEC	chr12	754302	Missense_Mutation	novel	E246V	0.58
UCEC	chr12	830085	Missense_Mutation	novel	M412I	0.53
UCEC	chr12	859405	Missense_Mutation	novel	A521S	0.14
UCEC	chr12	869111	Intron	novel		0.21
UCEC	chr12	881957	Missense_Mutation	rs750958116	V1086I	0.12
UCEC	chr12	885621	Missense_Mutation	novel	P1606L	0.17
UCEC	chr12	897606	Nonsense_Mutation	novel	R2125*	0.19
UCEC	chr12	879913	Missense_Mutation	NA	Q905R	0.48
UCEC	chr12	868877	Intron	rs537586813		0.43
UCEC	chr12	830086	Missense_Mutation	NA	L413F	0.38
UCEC	chr12	883524	Nonsense_Mutation	NA	E1207*	0.33
UCEC	chr12	885091	Silent	NA	P1429P	0.04
UCEC	chr12	896089	Missense_Mutation	rs766436838	G1868S	0.23
UCEC	chr12	896250	Silent	NA	V1921V	0.41
UCEC	chr12	880901	Missense_Mutation	novel	V1005I	0.38
UCEC	chr12	885249	Missense_Mutation	novel	S1482N	0.38
UCEC	chr12	885489	Missense_Mutation	novel	S1562F	0.42
UCEC	chr12	896670	Silent	rs201207378	S2061S	0.38
UCEC	chr12	897637	Missense_Mutation	novel	S2135F	0.33
UCEC	chr12	869008	Intron	novel		0.36
UCEC	chr12	885380	Missense_Mutation	rs772706007	A1526T	0.27
UCEC	chr12	896213	Missense_Mutation	rs548442202	P1909L	0.46
UCS	chr12	884165	In_Frame_Del	novel	R1256_V1260del	0.1
UCS	chr12	862134	Missense_Mutation	rs753167766	R668Q	0.65
UCS	chr12	813764	Silent	novel	K294K	0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	AMP	0.213	8.7884e-05
DLBC	DEL	0.0833	0.11856
HNSC	AMP	0.272	0.00099519
LUSC	AMP	0.4092	0.0059474
OV	AMP	0.5337	1.6751e-06
PAAD	AMP	0.1576	0.0041088
READ	AMP	0.2121	0.027505
TGCT	AMP	0.9333	3.5918e-21
THYM	AMP	0.0325	0.24554

Survival Analysis

Cancer	P-value	Q-value
MESO	0.00091	Kaplan-Meier Survival Analysis
ACC	0.044	Kaplan-Meier Survival Analysis
SKCM	0.0093	Kaplan-Meier Survival Analysis
ESCA	0.028	Kaplan-Meier Survival Analysis
KIRP	0.0081	Kaplan-Meier Survival Analysis
BLCA	0.025	Kaplan-Meier Survival Analysis
LIHC	0.0011	Kaplan-Meier Survival Analysis
LGG	0.05	Kaplan-Meier Survival Analysis
CHOL	0.041	Kaplan-Meier Survival Analysis
UVM	0.0084	Kaplan-Meier Survival Analysis
OV	0.0043	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000060237 (Gene tree)
Gene ID: 65125
Gene Symbol: WNK1
Alias: HSAN2|PPP1R167|PRKWNK1|HSN2
Full Name: WNK lysine deficient protein kinase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 158,860 bases
Position: chr12:752,593-911,452
Accession: 14540
RBP type: non-canonical RBP
Summary: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000545285	WNK1-219	528	-	ENSP00000446462	176 (aa)	-	H0YH79
ENST00000447667	WNK1-203	1902	-	ENSP00000392542	393 (aa)	-	F6UYG0
ENST00000544965	WNK1-217	653	-	ENSP00000438313	218 (aa)	-	H0YFF1
ENST00000544559	WNK1-216	226	-	ENSP00000437503	76 (aa)	-	H0YF81
ENST00000545055	WNK1-218	624	-	-	- (aa)	-	-
ENST00000574679	WNK1-221	722	-	ENSP00000459380	240 (aa)	-	I3L251
ENST00000340908	WNK1-202	11208	XM_011521001	ENSP00000341292	2634 (aa)	XP_011519303	Q9H4A3
ENST00000574564	WNK1-220	1401	-	ENSP00000460651	434 (aa)	-	A0A0B4J299
ENST00000540360	WNK1-211	668	-	-	- (aa)	-	-
ENST00000537687	WNK1-209	11232	XM_011520997	ENSP00000444465	2642 (aa)	XP_011519299	Q9H4A3
ENST00000540885	WNK1-212	874	-	-	- (aa)	-	-
ENST00000542543	WNK1-214	506	-	-	- (aa)	-	-
ENST00000538787	WNK1-210	579	-	-	- (aa)	-	-
ENST00000535698	WNK1-207	736	-	ENSP00000439552	245 (aa)	-	H0YFP5
ENST00000535572	WNK1-206	9886	XM_011521008	ENSP00000441972	2134 (aa)	XP_011519310	F5GWT4
ENST00000537603	WNK1-208	553	-	-	- (aa)	-	-
ENST00000542424	WNK1-213	912	-	-	- (aa)	-	-
ENST00000315939	WNK1-201	10452	XM_006719003	ENSP00000313059	2382 (aa)	XP_006719066	Q9H4A3
ENST00000543065	WNK1-215	201	-	ENSP00000438985	67 (aa)	-	H0YFK5
ENST00000534872	WNK1-205	584	-	ENSP00000446253	194 (aa)	-	H0YH68
ENST00000530271	WNK1-204	11804	-	ENSP00000433548	2833 (aa)	-	Q9H4A3

Gene Model

Click here to download ENSG00000060237's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000060237	Blood Pressure	1.7526904E-005	-
ENSG00000060237	Blood Pressure	7.5949174E-005	-
ENSG00000060237	Blood Pressure	7.7059493E-005	-
ENSG00000060237	Body Mass Index	6E-6	25673413
ENSG00000060237	Body Mass Index	2E-7	25673413
ENSG00000060237	Body Mass Index	2E-7	25673413
ENSG00000060237	Colorectal Neoplasms	3E-6	24836286

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000060237	rs7953330	12	889653	G	Lung cancer	28604730	[1.06-1.12]	1.0911875	EFO_0001071
ENSG00000060237	rs7953330	12	889653	G	Squamous cell lung carcinoma	28604730	[1.11-1.2]	1.1567484	EFO_0000708
ENSG00000060237	rs4619206	12	893691	C	Lung cancer in ever smokers	28604730	[1.07-1.14]	1.1038703	EFO_0006527\|EFO_0001071
ENSG00000060237	rs12301299	12	882544	C	Blood protein levels	29875488	[0.19-0.31] unit increase	0.25	EFO_0007937
ENSG00000060237	rs12309274	12	866782	T	Colorectal cancer	24836286	[1.06-1.16]	1.11	EFO_0005842
ENSG00000060237	rs11613704	12	871759	A	Eosinophil percentage of white cells	27863252	[0.021-0.038] unit increase	0.02968211	EFO_0007991
ENSG00000060237	rs11613704	12	871759	A	Eosinophil counts	27863252	[0.021-0.038] unit increase	0.02963015	EFO_0004842
ENSG00000060237	rs11611246	12	830314	T	Body mass index	26426971	unit increase	0.024242502	EFO_0004340
ENSG00000060237	rs11611246	12	830314	G	Body mass index	30108127	[NR] unit decrease	0.022	EFO_0004340
ENSG00000060237	rs372936466	12	864111	?	Heel bone mineral density	30048462	[0.017-0.034] unit increase	0.0253698	EFO_0009270
ENSG00000060237	rs55726687	12	882140	?	Body mass index	30595370			EFO_0004340
ENSG00000060237	rs10774463	12	792399	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000060237's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	-	IEA	Function
GO:0002028	regulation of sodium ion transport	-	ISS	Process
GO:0003084	positive regulation of systemic arterial blood pressure	-	IEA	Process
GO:0004672	protein kinase activity	16669787.	IMP	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	10660600.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	27400149.	ISS	Function
GO:0004674	protein serine/threonine kinase activity	24393035.	TAS	Function
GO:0005515	protein binding	15350218.16832045.17721439.19389623.	IPI	Function
GO:0005524	ATP binding	10660600.	IDA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	10660600.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	ISS	Component
GO:0006468	protein phosphorylation	21873635.	IBA	Process
GO:0006468	protein phosphorylation	10660600.	IDA	Process
GO:0006468	protein phosphorylation	16669787.	IMP	Process
GO:0006811	ion transport	-	ISS	Process
GO:0010766	negative regulation of sodium ion transport	21873635.	IBA	Process
GO:0010820	positive regulation of T cell chemotaxis	27400149.	IMP	Process
GO:0010923	negative regulation of phosphatase activity	19389623.	IDA	Process
GO:0016020	membrane	-	ISS	Component
GO:0018105	peptidyl-serine phosphorylation	27400149.	ISS	Process
GO:0018107	peptidyl-threonine phosphorylation	24393035.	TAS	Process
GO:0019869	chloride channel inhibitor activity	21873635.	IBA	Function
GO:0019869	chloride channel inhibitor activity	17673510.	IDA	Function
GO:0019870	potassium channel inhibitor activity	21873635.	IBA	Function
GO:0019901	protein kinase binding	16669787.	IPI	Function
GO:0019902	phosphatase binding	19389623.	IDA	Function
GO:0023016	signal transduction by trans-phosphorylation	16669787.	IDA	Process
GO:0030291	protein serine/threonine kinase inhibitor activity	-	IEA	Function
GO:0030295	protein kinase activator activity	16669787.	IMP	Function
GO:0032147	activation of protein kinase activity	-	IEA	Process
GO:0032414	positive regulation of ion transmembrane transporter activity	21873635.	IBA	Process
GO:0033633	negative regulation of cell-cell adhesion mediated by integrin	27400149.	IMP	Process
GO:0034115	negative regulation of heterotypic cell-cell adhesion	27400149.	IMP	Process
GO:0034260	negative regulation of GTPase activity	27400149.	IMP	Process
GO:0035556	intracellular signal transduction	21873635.	IBA	Process
GO:0035556	intracellular signal transduction	10660600.	IDA	Process
GO:0035556	intracellular signal transduction	24393035.	TAS	Process
GO:0038116	chemokine (C-C motif) ligand 21 signaling pathway	27400149.	ISS	Process
GO:0046777	protein autophosphorylation	-	IEA	Process
GO:0048666	neuron development	15060842.	NAS	Process
GO:0050794	regulation of cellular process	-	ISS	Process
GO:0050801	ion homeostasis	21873635.	IBA	Process
GO:0050852	T cell receptor signaling pathway	27400149.	ISS	Process
GO:0071277	cellular response to calcium ion	-	IEA	Process
GO:0071901	negative regulation of protein serine/threonine kinase activity	-	IEA	Process
GO:0090188	negative regulation of pancreatic juice secretion	-	IEA	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	23797875.	IMP	Process
GO:0097022	lymphocyte migration into lymph node	27400149.	ISS	Process
GO:1903038	negative regulation of leukocyte cell-cell adhesion	27400149.	IMP	Process
GO:1903288	positive regulation of potassium ion import	21873635.	IBA	Process
GO:1990869	cellular response to chemokine	27400149.	IMP	Process
GO:2000651	positive regulation of sodium ion transmembrane transporter activity	21873635.	IBA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.