EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23813671	The over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B.	Prostate	2013 Sep	Ren K	doi: 10.1002/pros.22693
27773818	Muscarinic acetylcholine receptors mediate eIF4B phosphorylation in SNU-407 colon cancer cells.	Biochem Biophys Res Commun	2016 Nov 18	Liu Z	doi: 10.1016/j.bbrc.2016.10.069
27528663	Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.	Proc Natl Acad Sci U S A	2016 Aug 30	Wang Y	doi: 10.1073/pnas.1606862113
29124675	Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.	Pathol Oncol Res	2019 Jan	Ren K	doi: 10.1007/s12253-017-0353-9

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr12	53019934	Missense_Mutation	novel	E129K	0.12	RRM_1
BLCA	chr12	53006322	5'UTR	novel		0.15
BLCA	chr12	53016601	Missense_Mutation	novel	E48K	0.22
BLCA	chr12	53020021	Missense_Mutation	novel	E158K	0.41	RRM_1
BLCA	chr12	53040291	3'UTR	novel		0.08
BLCA	chr12	53040142	Splice_Site	novel	X586_splice	0.21
BLCA	chr12	53040247	3'UTR	novel		0.5
BRCA	chr12	53022311	Intron	novel		0.27
BRCA	chr12	53019949	Missense_Mutation	NA	E134K	0.09	RRM_1
BRCA	chr12	53019949	Missense_Mutation	NA	E134Q	0.12	RRM_1
BRCA	chr12	53006402	5'UTR	novel		0.21
BRCA	chr12	53027876	Silent	novel	G254G	0.09
BRCA	chr12	53028020	Missense_Mutation	NA	D271N	0.2
BRCA	chr12	53033808	Frame_Shift_Del	NA	*Q330Kfs5**	0.08
CESC	chr12	53016526	Nonsense_Mutation	NA	E23*	0.48
CESC	chr12	53033862	Missense_Mutation	novel	D346N	0.17
CESC	chr12	53037487	Missense_Mutation	NA	S462C	0.16
CESC	chr12	53006282	5'UTR	novel		0.4
CESC	chr12	53018905	Missense_Mutation	novel	R87W	0.18
CESC	chr12	53033808	Frame_Shift_Del	NA	*Q330Kfs5**	0.39
CESC	chr12	53028074	Missense_Mutation	NA	D289N	0.29
COAD	chr12	53039385	Intron	NA		0.37
COAD	chr12	53039240	Nonsense_Mutation	novel	E527*	0.06
COAD	chr12	53040275	3'UTR	novel		0.09
COAD	chr12	53027895	Nonsense_Mutation	NA	R261*	0.35
COAD	chr12	53039264	Missense_Mutation	novel	A535S	0.06
COAD	chr12	53037603	Missense_Mutation	novel	E501Q	0.5
COAD	chr12	53040066	Intron	novel		0.27
COAD	chr12	53028132	Missense_Mutation	rs758683560	R308Q	0.4
COAD	chr12	53033808	Frame_Shift_Del	NA	*Q330Kfs5**	0.55
COAD	chr12	53033991	Missense_Mutation	rs747657993	R389C	0.33
COAD	chr12	53039724	Intron	NA		0.31
COAD	chr12	53027793	Missense_Mutation	NA	R227C	0.16
COAD	chr12	53018911	Missense_Mutation	NA	R89S	0.16
COAD	chr12	53034626	Missense_Mutation	rs753615463	R408Q	0.3
COAD	chr12	53022311	Intron	novel		0.12
ESCA	chr12	53040228	3'UTR	novel		0.27
ESCA	chr12	53006402	5'UTR	novel		0.3
ESCA	chr12	53006388	5'UTR	novel		0.26
GBM	chr12	53033832	Missense_Mutation	novel	L336I	0.21
GBM	chr12	53027794	Missense_Mutation	rs763817075	R227H	0.31
GBM	chr12	53022360	Intron	novel		0.38
GBM	chr12	53019007	Splice_Site	novel	X120_splice	0.5
HNSC	chr12	53040185	Missense_Mutation	novel	G600S	0.19
HNSC	chr12	53006402	5'UTR	novel		0.17
HNSC	chr12	53028065	Missense_Mutation	rs776635410	R286C	0.09
HNSC	chr12	53039358	Intron	novel		0.18
HNSC	chr12	53016483	Missense_Mutation	novel	K8N	0.26
HNSC	chr12	53028149	Missense_Mutation	novel	D314H	0.22
HNSC	chr12	53016607	Missense_Mutation	novel	D50H	0.17
HNSC	chr12	53006490	Frame_Shift_Ins	novel	*S4Lfs7**	0.62
HNSC	chr12	53006494	Missense_Mutation	novel	S4L	0.1
KIRC	chr12	53018992	Missense_Mutation	novel	F116L	0.19	RRM_1
KIRC	chr12	53039788	Intron	novel		0.27
KIRP	chr12	53038389	Silent	novel	S518S	0.52
KIRP	chr12	53037495	Missense_Mutation	NA	P465S	0.16
KIRP	chr12	53022529	Missense_Mutation	NA	R190P	0.13
LGG	chr12	53018957	Missense_Mutation	novel	P104L	0.11	RRM_1
LGG	chr12	53037489	Missense_Mutation	NA	K463E	0.47
LGG	chr12	53039294	Missense_Mutation	novel	R545C	0.09
LGG	chr12	53040309	3'UTR	novel		0.18
LIHC	chr12	53039948	Intron	novel		0.33
LUAD	chr12	53033807	Splice_Region	novel	G327G	0.31
LUAD	chr12	53033832	Missense_Mutation	NA	L336V	0.23
LUAD	chr12	53028091	Silent	rs540767038	G294G	0.1
LUAD	chr12	53006482	5'UTR	novel		0.22
LUAD	chr12	53018824	Missense_Mutation	NA	D60N	0.32
LUAD	chr12	53037588	Missense_Mutation	NA	Q496E	0.09
LUAD	chr12	53019932	Missense_Mutation	novel	R128L	0.31	RRM_1
LUAD	chr12	53006404	5'UTR	novel		0.47
LUAD	chr12	53037543	Missense_Mutation	novel	E481Q	0.33
LUAD	chr12	53033854	Missense_Mutation	NA	K343R	0.4
LUAD	chr12	53040309	3'UTR	novel		0.12
LUAD	chr12	53040310	3'UTR	novel		0.12
LUAD	chr12	53006337	5'UTR	novel		0.33
LUSC	chr12	53027913	Missense_Mutation	NA	D267H	0.28
LUSC	chr12	53006300	5'UTR	novel		0.33
LUSC	chr12	53016569	Missense_Mutation	NA	P37Q	0.09
LUSC	chr12	53016598	Missense_Mutation	novel	L47M	0.16
LUSC	chr12	53034647	Missense_Mutation	NA	R415L	0.14
LUSC	chr12	53006447	5'UTR	rs746486551		0.17
LUSC	chr12	53037412	Missense_Mutation	rs367932879	A437V	0.21
OV	chr12	53039679	Missense_Mutation	novel	K578E	0.1
OV	chr12	53022517	Missense_Mutation	rs746524556	R186H	0.36
OV	chr12	53006414	5'UTR	novel		0.09
PAAD	chr12	53028032	Missense_Mutation	novel	G275C	0.05
PAAD	chr12	53028066	Missense_Mutation	rs758912816	R286H	0.04
PAAD	chr12	53033851	Missense_Mutation	novel	P342H	0.23
PRAD	chr12	53006366	5'UTR	novel		0.26
PRAD	chr12	53027866	Missense_Mutation	novel	R251Q	0.44
READ	chr12	53040345	3'UTR	novel		0.4
READ	chr12	53018995	Nonsense_Mutation	NA	R117*	0.38	RRM_1
READ	chr12	53039398	Intron	novel		0.39
READ	chr12	53033949	Nonsense_Mutation	novel	E375*	0.1
SARC	chr12	53033843	Silent	novel	R339R	0.19
SARC	chr12	53033888	Silent	novel	S354S	0.26
SKCM	chr12	53018924	Missense_Mutation	novel	S93W	0.62
SKCM	chr12	53019937	Missense_Mutation	novel	P130S	0.26	RRM_1
SKCM	chr12	53027793	Missense_Mutation	NA	R227C	0.14
SKCM	chr12	53027850	Missense_Mutation	NA	R246C	0.22
SKCM	chr12	53037415	Missense_Mutation	rs370487271	R438Q	0.22
SKCM	chr12	53033820	Missense_Mutation	NA	P332S	0.33
SKCM	chr12	53019949	Missense_Mutation	NA	E134K	0.17	RRM_1
SKCM	chr12	53040075	Intron	novel		0.43
SKCM	chr12	53033812	Missense_Mutation	NA	P329L	0.46
SKCM	chr12	53028097	Silent	NA	D296D	0.58
SKCM	chr12	53027793	Missense_Mutation	NA	R227C	0.29
SKCM	chr12	53027788	Missense_Mutation	NA	R225Q	0.41
STAD	chr12	53027839	Missense_Mutation	rs374172229	R242Q	0.33
STAD	chr12	53039325	Missense_Mutation	novel	H555R	0.31
STAD	chr12	53019969	Silent	NA	G140G	0.23
STAD	chr12	53018969	Missense_Mutation	novel	T108I	0.11	RRM_1
STAD	chr12	53039626	Splice_Region	novel		0.5
STAD	chr12	53040108	Intron	novel		0.42
STAD	chr12	53040130	Intron	rs763043784		0.33
STAD	chr12	53034652	Missense_Mutation	rs374072301	R417W	0.13
STAD	chr12	53018840	Missense_Mutation	rs764677800	A65V	0.19
STAD	chr12	53039224	Intron	novel		0.21
STAD	chr12	53040191	Missense_Mutation	rs778266609	D602H	0.24
STAD	chr12	53028102	Missense_Mutation	NA	Y298C	0.3
TGCT	chr12	53016555	Silent	rs373400973	T32T	0.24
THCA	chr12	53040309	3'UTR	novel		0.22
THCA	chr12	53040310	3'UTR	novel		0.22
THYM	chr12	53006463	5'UTR	novel		0.14
UCEC	chr12	53040314	3'UTR	novel		0.12
UCEC	chr12	53033808	Frame_Shift_Del	NA	*Q330Kfs5**	0.15
UCEC	chr12	53028066	Missense_Mutation	rs758912816	R286H	0.37
UCEC	chr12	53039742	Intron	novel		0.09
UCEC	chr12	53028060	Missense_Mutation	novel	G284E	0.19
UCEC	chr12	53018999	Missense_Mutation	NA	G118V	0.19	RRM_1
UCEC	chr12	53006322	5'UTR	novel		0.08
UCEC	chr12	53034005	Missense_Mutation	novel	E393D	0.44
UCEC	chr12	53038379	Missense_Mutation	novel	A515V	0.4
UCEC	chr12	53028091	Silent	rs540767038	G294G	0.37
UCEC	chr12	53039350	Splice_Region	NA		0.48
UCEC	chr12	53018973	Missense_Mutation	NA	E109D	0.37	RRM_1
UCEC	chr12	53016551	Missense_Mutation	NA	S31I	0.19
UCEC	chr12	53027866	Missense_Mutation	novel	R251Q	0.05
UCEC	chr12	53028162	Missense_Mutation	rs561749624	R318Q	0.29
UCEC	chr12	53018901	Silent	rs150784992	I85I	0.21
UCEC	chr12	53040128	Intron	novel		0.2
UCEC	chr12	53006457	5'UTR	novel		0.11
UCEC	chr12	53039497	Intron	NA		0.4
UCEC	chr12	53042101	3'UTR	novel		0.36
UCEC	chr12	53039549	Intron	novel		0.13
UCEC	chr12	53033842	Missense_Mutation	novel	R339Q	0.33
UCEC	chr12	53022305	Intron	novel		0.32
UCEC	chr12	53027893	Missense_Mutation	NA	D260G	0.4
UCEC	chr12	53027783	Missense_Mutation	novel	K223N	0.56
UCEC	chr12	53028134	Missense_Mutation	novel	S309P	0.25
UCEC	chr12	53041894	3'UTR	novel		0.44
UCEC	chr12	53022268	Intron	novel		0.27
UCEC	chr12	53027793	Missense_Mutation	NA	R227C	0.22
UCEC	chr12	53006302	5'UTR	novel		0.11
UCEC	chr12	53021827	Nonsense_Mutation	NA	R167*	0.43	RRM_1
UCEC	chr12	53021822	Missense_Mutation	novel	R165I	0.05	RRM_1
UCEC	chr12	53039193	Intron	novel		0.35
UCEC	chr12	53040305	3'UTR	novel		0.14
UCEC	chr12	53042088	3'UTR	novel		0.21
UCEC	chr12	53016492	Frame_Shift_Del	novel	*K13Rfs5**	0.29
UCEC	chr12	53033896	Missense_Mutation	novel	A357V	0.33
UCEC	chr12	53028123	Missense_Mutation	novel	R305Q	0.44
UCEC	chr12	53027868	Frame_Shift_Ins	novel	*Y252Sfs20**	0.05
UCEC	chr12	53018802	Silent	rs768620703	S52S	0.5
UCEC	chr12	53039097	Intron	novel		0.29
UCEC	chr12	53018939	Missense_Mutation	novel	A98V	0.41
UCEC	chr12	53006421	5'UTR	novel		0.4
UCEC	chr12	53022505	Missense_Mutation	rs758335712	R182H	0.4
UCEC	chr12	53019937	Missense_Mutation	novel	P130S	0.08	RRM_1
UCEC	chr12	53022505	Missense_Mutation	rs758335712	R182H	0.23
UCEC	chr12	53028066	Missense_Mutation	rs758912816	R286H	0.1
UCEC	chr12	53037436	Missense_Mutation	novel	S445Y	0.39
UCS	chr12	53040177	Missense_Mutation	novel	S597C	0.24
UCS	chr12	53021753	Intron	novel		0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.1875	0.085003
READ	DEL	0.0667	0.064633
STAD	DEL	0.0952	0.22179

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
UCS	0.015	Kaplan-Meier Survival Analysis
KIRP	0.027	Kaplan-Meier Survival Analysis
BLCA	0.013	Kaplan-Meier Survival Analysis
CESC	0.015	Kaplan-Meier Survival Analysis
LIHC	0.009	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000063046 (Gene tree)
Gene ID: 1975
Gene Symbol: EIF4B
Alias: N
Full Name: eukaryotic translation initiation factor 4B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 36,052 bases
Position: chr12:53,006,158-53,042,209
Accession: 3285
RBP type: canonical RBP
Summary: (Eukaryotic Translation Initiation Factor 4B) is a Protein Coding gene. Among its related pathways are mTOR signaling pathway (KEGG) and RET signaling. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is EIF4H.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000447192	RRM_1	PF00076.22	6.1e-13	1	1
ENSP00000450324	RRM_1	PF00076.22	1.5e-12	1	1
ENSP00000449746	RRM_1	PF00076.22	2.2e-12	1	1
ENSP00000262056	RRM_1	PF00076.22	4.8e-12	1	1
ENSP00000388806	RRM_1	PF00076.22	4.9e-12	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8139536	The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence.	Mol Cell Biol	1994 Apr	Methot N	-
9195926	Translation initiation factors eIF-iso4G and eIF-4B interact with the poly(A)-binding protein and increase its RNA binding activity.	J Biol Chem	1997 Jun 27	Le H	-
15528191	Interaction between the NH2-terminal domain of eIF4A and the central domain of eIF4G modulates RNA-stimulated ATPase activity.	J Biol Chem	2005 Jan 21	Korneeva NL	-
16803875	Wheat eukaryotic initiation factor 4B organizes assembly of RNA and eIFiso4G, eIF4A, and poly(A)-binding protein.	J Biol Chem	2006 Aug 25	Cheng S	-
2390971	Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.	EMBO J	1990 Sep	Milburn SC	-
9254700	Sce3, a suppressor of the Schizosaccharomyces pombe septation mutant cdc11, encodes a putative RNA-binding protein.	Nucleic Acids Res	1997 Sep 1	Schmidt S	-
10747998	The phosphorylation state of poly(A)-binding protein specifies its binding to poly(A) RNA and its interaction with eukaryotic initiation factor (eIF) 4F, eIFiso4F, and eIF4B.	J Biol Chem	2000 Jun 9	Le H	-
6712925	Eucaryotic initiation factor 4B of wheat germ binds to the translation initiation region of a messenger ribonucleic acid.	Biochemistry	1984 Feb 28	Butler JS	-
9769100	The RNA recognition motif of yeast translation initiation factor Tif3/eIF4B is required but not sufficient for RNA strand-exchange and translational activity.	RNA	1998 Oct	Niederberger N	-
18719248	Interactions between eIF4AI and its accessory factors eIF4B and eIF4H.	RNA	2008 Oct	Rozovsky N	doi: 10.1261/rna.1049608
211427	Initiation activity of EMC virus RNA, binding to initiation factor eIF-4B and shut-off of host cell protein synthesis.	Nature	1978 Sep 21	Baglioni C	-
8182051	Two structural domains of initiation factor eIF-4B are involved in binding to RNA.	J Biol Chem	1994 May 20	Naranda T	-
15254188	Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein.	J Virol	2004 Aug	Kuyumcu-Martinez M	-
15071500	Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.	EMBO J	2004 Apr 21	Raught B	-
19835415	How does a scanning ribosomal particle move along the 5'-untranslated region of eukaryotic mRNA? Brownian Ratchet model.	Biochemistry	2009 Nov 17	Spirin AS	doi: 10.1021/bi901379a.
18977752	Translation initiation factor 4B homodimerization, RNA binding, and interaction with Poly(A)-binding protein are enhanced by zinc.	J Biol Chem	2008 Dec 26	Cheng S	doi: 10.1074/jbc.M807716200
24063684	Impaired binding of standard initiation factors eIF3b, eIF4G and eIF4B to domain V of the live-attenuated coxsackievirus B3 Sabin3-like IRES--alternatives for 5'UTR-related cardiovirulence mechanisms.	Diagn Pathol	2013 Sep 24	Souii A	doi: 10.1186/1746-1596-8-161.
12477816	Impaired binding of standard initiation factors mediates poliovirus translation attenuation.	J Virol	2003 Jan	Ochs K	-
11418588	Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F.	J Biol Chem	2001 Aug 17	Rogers GW Jr	-
16030146	Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation.	Proc Natl Acad Sci U S A	2005 Jul 26	Bordeleau ME	-
18367715	Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking.	RNA	2008 May	Lindqvist L	doi: 10.1261/rna.971208
24961997	Magnesium-dependent folding of a picornavirus IRES element modulates RNA conformation and eIF4G interaction.	FEBS J	2014 Aug	Lozano G	doi: 10.1111/febs.12890
681329	Initiation factor eIF-4B (IF-M3)-dependent recognition and translation of capped versus uncapped eukaryotic mRNAs.	J Biol Chem	1978 Sep 10	Padilla M	-
19858189	Kinetic mechanism for the binding of eIF4F and tobacco Etch virus internal ribosome entry site rna: effects of eIF4B and poly(A)-binding protein.	J Biol Chem	2009 Dec 18	Khan MA	doi: 10.1074/jbc.M109.038463.
25673016	In vitro-reduced translation efficiency of coxsackievirus B3 Sabin3-like strain is correlated to impaired binding of cellular initiation factors to viral IRES RNA.	Curr Microbiol	2015 May	Ben M'hadheb M	doi: 10.1007/s00284-015-0784-z
2440886	Identification of two messenger RNA cap binding proteins in wheat germ. Evidence that the 28-kDa subunit of eIF-4B and the 26-kDa subunit of eIF-4F are antigenically distinct polypeptides.	J Biol Chem	1987 Aug 15	Browning KS	-
2304461	Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.	Mol Cell Biol	1990 Mar	Rozen F	-
11565745	IRES interaction with translation initiation factors: functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII.	RNA	2001 Sep	Lopez de Quinto S	-
10748132	Wheat germ poly(A)-binding protein increases the ATPase and the RNA helicase activity of translation initiation factors eIF4A, eIF4B, and eIF-iso4F.	J Biol Chem	2000 Jun 9	Bi X	-
16014927	mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.	J Virol	2005 Aug	Feng P	-
18692164	Effects of poly(A)-binding protein on the interactions of translation initiation factor eIF4F and eIF4F.4B with internal ribosome entry site (IRES) of tobacco etch virus RNA.	Biochim Biophys Acta	2008 Oct	Khan MA	doi: 10.1016/j.bbagrm.2008.07.004
17606619	eIF4G, eIFiso4G, and eIF4B bind the poly(A)-binding protein through overlapping sites within the RNA recognition motif domains.	J Biol Chem	2007 Aug 31	Cheng S	-
20948310	eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways.	Cell Cycle	2010 Oct 15	Shahbazian D	-
20723624	Poly(A) tail affects equilibrium and thermodynamic behavior of tobacco etch virus mRNA with translation initiation factors eIF4F, eIF4B and PABP.	Biochim Biophys Acta	2010 Sep	Yumak H	doi: 10.1016/j.bbagrm.2010.08.003
25332164	Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control.	J Cell Biol	2014 Oct 27	Eom T	doi: 10.1083/jcb.201401005
26779409	The role of the poly(A) binding protein in the assembly of the Cap-binding complex during translation initiation in plants.	Translation (Austin)	2014 Oct 30	Gallie DR	doi: 10.4161/2169074X.2014.959378

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000552490	EIF4B-213	841	-	ENSP00000450324	275 (aa)	-	F8VP89
ENST00000550704	EIF4B-210	1476	-	ENSP00000448365	227 (aa)	-	F8VSC7
ENST00000416762	EIF4B-202	1985	-	ENSP00000412530	572 (aa)	-	P23588
ENST00000549077	EIF4B-204	885	-	ENSP00000448399	175 (aa)	-	F8VRU1
ENST00000550025	EIF4B-208	465	-	-	- (aa)	-	-
ENST00000549645	EIF4B-207	590	-	-	- (aa)	-	-
ENST00000553209	EIF4B-214	380	-	-	- (aa)	-	-
ENST00000420463	EIF4B-203	1936	-	ENSP00000388806	616 (aa)	-	E7EX17
ENST00000549592	EIF4B-206	1901	-	-	- (aa)	-	-
ENST00000549481	EIF4B-205	1097	-	ENSP00000449746	360 (aa)	-	F8VX11
ENST00000262056	EIF4B-201	4148	-	ENSP00000262056	611 (aa)	-	P23588
ENST00000551527	EIF4B-212	769	-	-	- (aa)	-	-
ENST00000551002	EIF4B-211	537	-	ENSP00000447192	169 (aa)	-	F8W0K0
ENST00000550390	EIF4B-209	871	-	ENSP00000448980	185 (aa)	-	F8VYE9

Gene Model

Click here to download ENSG00000063046's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa05205	Proteoglycans in cancer	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000063046	rs115019703	12	53013228	A	Highest math class taken (MTAG)	30038396	[0.018-0.038] unit increase	0.0282	EFO_0004875

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000063046's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000063046	EIF4B	70	32.937	ENSG00000106682	EIF4H	86	32.472

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000063046	EIF4B	96	79.775	ENSAPOG00000022990	eif4bb	99	57.895	Acanthochromis_polyacanthus
ENSG00000063046	EIF4B	100	97.633	ENSAMEG00000012023	EIF4B	100	95.098	Ailuropoda_melanoleuca
ENSG00000063046	EIF4B	96	80.899	ENSACIG00000015658	eif4bb	99	59.845	Amphilophus_citrinellus
ENSG00000063046	EIF4B	96	79.213	ENSAOCG00000000713	eif4bb	99	57.879	Amphiprion_ocellaris
ENSG00000063046	EIF4B	96	79.213	ENSAPEG00000004732	eif4bb	99	58.030	Amphiprion_percula
ENSG00000063046	EIF4B	98	73.988	ENSATEG00000024049	eif4bb	96	59.098	Anabas_testudineus
ENSG00000063046	EIF4B	100	90.643	ENSACAG00000011869	EIF4B	97	75.680	Anolis_carolinensis
ENSG00000063046	EIF4B	100	97.727	ENSANAG00000021956	-	99	99.467	Aotus_nancymaae
ENSG00000063046	EIF4B	98	91.480	ENSANAG00000030795	-	98	79.830	Aotus_nancymaae
ENSG00000063046	EIF4B	98	91.031	ENSANAG00000032230	-	100	86.201	Aotus_nancymaae
ENSG00000063046	EIF4B	100	85.799	ENSANAG00000022099	-	100	77.700	Aotus_nancymaae
ENSG00000063046	EIF4B	98	96.970	ENSANAG00000027568	-	99	92.246	Aotus_nancymaae
ENSG00000063046	EIF4B	100	91.716	ENSANAG00000026408	-	100	80.446	Aotus_nancymaae
ENSG00000063046	EIF4B	96	79.775	ENSACLG00000009013	eif4bb	97	59.398	Astatotilapia_calliptera
ENSG00000063046	EIF4B	96	82.320	ENSAMXG00000041675	eif4ba	100	61.398	Astyanax_mexicanus
ENSG00000063046	EIF4B	96	78.652	ENSAMXG00000034236	eif4bb	95	54.977	Astyanax_mexicanus
ENSG00000063046	EIF4B	100	96.450	ENSBTAG00000006883	EIF4B	100	95.581	Bos_taurus
ENSG00000063046	EIF4B	98	95.516	ENSCJAG00000046740	-	94	96.875	Callithrix_jacchus
ENSG00000063046	EIF4B	100	98.377	ENSCJAG00000018176	EIF4B	99	99.467	Callithrix_jacchus
ENSG00000063046	EIF4B	100	97.041	ENSCAFG00000007117	EIF4B	100	96.078	Canis_familiaris
ENSG00000063046	EIF4B	96	95.480	ENSCAFG00020023868	-	96	95.531	Canis_lupus_dingo
ENSG00000063046	EIF4B	98	97.674	ENSCAFG00020021666	-	94	97.674	Canis_lupus_dingo
ENSG00000063046	EIF4B	96	86.441	ENSCHIG00000016477	-	94	77.250	Capra_hircus
ENSG00000063046	EIF4B	100	96.450	ENSCHIG00000012380	-	100	95.942	Capra_hircus
ENSG00000063046	EIF4B	100	96.450	ENSTSYG00000012880	-	100	96.429	Carlito_syrichta
ENSG00000063046	EIF4B	98	73.543	ENSTSYG00000030094	-	100	69.854	Carlito_syrichta
ENSG00000063046	EIF4B	100	82.249	ENSCAPG00000011923	-	86	80.879	Cavia_aperea
ENSG00000063046	EIF4B	100	92.899	ENSCAPG00000009384	-	100	91.716	Cavia_aperea
ENSG00000063046	EIF4B	100	93.491	ENSCPOG00000021782	-	100	84.452	Cavia_porcellus
ENSG00000063046	EIF4B	100	95.858	ENSCPOG00000005595	-	100	94.780	Cavia_porcellus
ENSG00000063046	EIF4B	100	93.392	ENSCCAG00000028899	-	96	91.534	Cebus_capucinus
ENSG00000063046	EIF4B	100	98.214	ENSCCAG00000035872	-	100	98.214	Cebus_capucinus
ENSG00000063046	EIF4B	95	87.755	ENSCCAG00000036571	-	99	81.090	Cebus_capucinus
ENSG00000063046	EIF4B	98	75.000	ENSCCAG00000026166	-	95	77.019	Cebus_capucinus
ENSG00000063046	EIF4B	100	90.749	ENSCATG00000032438	-	93	90.761	Cercocebus_atys
ENSG00000063046	EIF4B	100	100.000	ENSCATG00000032007	-	100	92.703	Cercocebus_atys
ENSG00000063046	EIF4B	98	75.879	ENSCATG00000038513	-	100	76.105	Cercocebus_atys
ENSG00000063046	EIF4B	98	83.516	ENSCATG00000028753	-	96	83.516	Cercocebus_atys
ENSG00000063046	EIF4B	100	95.858	ENSCLAG00000013741	EIF4B	100	95.595	Chinchilla_lanigera
ENSG00000063046	EIF4B	99	86.393	ENSCSAG00000014290	-	100	85.761	Chlorocebus_sabaeus
ENSG00000063046	EIF4B	98	90.361	ENSCSAG00000007929	-	100	90.391	Chlorocebus_sabaeus
ENSG00000063046	EIF4B	100	98.854	ENSCSAG00000005574	-	100	98.854	Chlorocebus_sabaeus
ENSG00000063046	EIF4B	100	96.450	ENSCHOG00000001608	EIF4B	100	96.072	Choloepus_hoffmanni
ENSG00000063046	EIF4B	100	90.643	ENSCPBG00000019649	EIF4B	100	78.616	Chrysemys_picta_bellii
ENSG00000063046	EIF4B	90	44.643	ENSCING00000016816	-	95	35.694	Ciona_intestinalis
ENSG00000063046	EIF4B	84	43.243	ENSCSAVG00000001212	-	90	42.763	Ciona_savignyi
ENSG00000063046	EIF4B	93	40.456	ENSCSAVG00000001078	-	57	39.607	Ciona_savignyi
ENSG00000063046	EIF4B	99	99.115	ENSCANG00000035779	-	100	99.115	Colobus_angolensis_palliatus
ENSG00000063046	EIF4B	100	98.701	ENSCANG00000027371	-	100	98.701	Colobus_angolensis_palliatus
ENSG00000063046	EIF4B	89	88.667	ENSCANG00000033494	-	97	76.303	Colobus_angolensis_palliatus
ENSG00000063046	EIF4B	96	85.876	ENSCANG00000042944	-	96	83.516	Colobus_angolensis_palliatus
ENSG00000063046	EIF4B	100	74.838	ENSCANG00000043275	-	100	74.675	Colobus_angolensis_palliatus
ENSG00000063046	EIF4B	99	84.754	ENSCANG00000037506	-	98	86.224	Colobus_angolensis_palliatus
ENSG00000063046	EIF4B	100	96.450	ENSCGRG00001014070	Eif4b	100	96.236	Cricetulus_griseus_chok1gshd
ENSG00000063046	EIF4B	88	72.222	ENSCGRG00001009005	-	100	69.730	Cricetulus_griseus_chok1gshd
ENSG00000063046	EIF4B	88	72.222	ENSCGRG00000004684	-	100	69.730	Cricetulus_griseus_crigri
ENSG00000063046	EIF4B	100	96.450	ENSCGRG00000008920	Eif4b	100	96.236	Cricetulus_griseus_crigri
ENSG00000063046	EIF4B	96	82.682	ENSCSEG00000004853	eif4bb	99	70.927	Cynoglossus_semilaevis
ENSG00000063046	EIF4B	100	75.287	ENSCVAG00000021559	eif4bb	98	57.716	Cyprinodon_variegatus
ENSG00000063046	EIF4B	96	80.337	ENSDARG00000017439	eif4ba	96	64.045	Danio_rerio
ENSG00000063046	EIF4B	96	78.652	ENSDARG00000010194	eif4bb	99	56.703	Danio_rerio
ENSG00000063046	EIF4B	98	72.892	ENSDNOG00000035736	-	97	61.983	Dasypus_novemcinctus
ENSG00000063046	EIF4B	100	95.266	ENSDORG00000004008	Eif4b	99	95.581	Dipodomys_ordii
ENSG00000063046	EIF4B	89	32.773	FBgn0020660	eIF4B	50	32.870	Drosophila_melanogaster
ENSG00000063046	EIF4B	82	63.699	ENSEBUG00000013242	-	62	65.068	Eptatretus_burgeri
ENSG00000063046	EIF4B	92	58.824	ENSEBUG00000003312	-	86	59.302	Eptatretus_burgeri
ENSG00000063046	EIF4B	99	58.889	ENSEBUG00000007785	-	96	39.869	Eptatretus_burgeri
ENSG00000063046	EIF4B	100	97.041	ENSEASG00005009268	EIF4B	100	96.563	Equus_asinus_asinus
ENSG00000063046	EIF4B	100	97.041	ENSECAG00000024091	EIF4B	92	95.819	Equus_caballus
ENSG00000063046	EIF4B	96	77.049	ENSELUG00000011962	eif4bb	100	56.203	Esox_lucius
ENSG00000063046	EIF4B	100	72.159	ENSELUG00000012490	eif4ba	85	72.727	Esox_lucius
ENSG00000063046	EIF4B	100	97.727	ENSFCAG00000000300	EIF4B	100	97.727	Felis_catus
ENSG00000063046	EIF4B	100	86.628	ENSFALG00000004382	EIF4B	99	69.702	Ficedula_albicollis
ENSG00000063046	EIF4B	100	97.041	ENSFDAG00000009048	-	100	96.072	Fukomys_damarensis
ENSG00000063046	EIF4B	96	69.492	ENSFDAG00000014855	-	99	69.681	Fukomys_damarensis
ENSG00000063046	EIF4B	100	90.533	ENSFDAG00000014529	-	98	83.779	Fukomys_damarensis
ENSG00000063046	EIF4B	98	76.471	ENSFHEG00000006923	eif4bb	99	58.396	Fundulus_heteroclitus
ENSG00000063046	EIF4B	96	74.444	ENSGMOG00000019470	eif4bb	100	53.354	Gadus_morhua
ENSG00000063046	EIF4B	98	86.905	ENSGALG00000045352	EIF4B	65	67.799	Gallus_gallus
ENSG00000063046	EIF4B	96	81.461	ENSGAFG00000008327	eif4bb	99	59.571	Gambusia_affinis
ENSG00000063046	EIF4B	96	80.337	ENSGACG00000008010	eif4bb	99	57.277	Gasterosteus_aculeatus
ENSG00000063046	EIF4B	100	90.643	ENSGAGG00000025237	EIF4B	100	78.931	Gopherus_agassizii
ENSG00000063046	EIF4B	95	86.335	ENSGGOG00000037535	-	96	76.871	Gorilla_gorilla
ENSG00000063046	EIF4B	100	55.452	ENSGGOG00000039401	-	100	67.259	Gorilla_gorilla
ENSG00000063046	EIF4B	98	97.758	ENSGGOG00000040010	-	96	98.206	Gorilla_gorilla
ENSG00000063046	EIF4B	96	97.740	ENSGGOG00000004382	-	100	93.984	Gorilla_gorilla
ENSG00000063046	EIF4B	95	95.031	ENSGGOG00000037011	-	100	87.948	Gorilla_gorilla
ENSG00000063046	EIF4B	89	85.366	ENSGGOG00000036580	-	100	74.749	Gorilla_gorilla
ENSG00000063046	EIF4B	100	99.673	ENSGGOG00000013695	EIF4B	100	99.673	Gorilla_gorilla
ENSG00000063046	EIF4B	96	80.337	ENSHBUG00000023345	eif4bb	99	49.349	Haplochromis_burtoni
ENSG00000063046	EIF4B	100	91.124	ENSHGLG00000004627	-	100	88.052	Heterocephalus_glaber_female
ENSG00000063046	EIF4B	85	87.162	ENSHGLG00000018154	-	99	75.225	Heterocephalus_glaber_female
ENSG00000063046	EIF4B	89	96.129	ENSHGLG00000002541	-	99	96.129	Heterocephalus_glaber_female
ENSG00000063046	EIF4B	96	80.337	ENSHGLG00000003859	-	100	74.459	Heterocephalus_glaber_female
ENSG00000063046	EIF4B	97	71.284	ENSHGLG00000000983	-	100	70.101	Heterocephalus_glaber_female
ENSG00000063046	EIF4B	98	83.946	ENSHGLG00000007993	-	100	83.633	Heterocephalus_glaber_female
ENSG00000063046	EIF4B	92	83.851	ENSHGLG00100014557	-	100	85.542	Heterocephalus_glaber_male
ENSG00000063046	EIF4B	96	80.337	ENSHGLG00100001246	-	100	74.459	Heterocephalus_glaber_male
ENSG00000063046	EIF4B	85	86.486	ENSHGLG00100014712	-	99	76.577	Heterocephalus_glaber_male
ENSG00000063046	EIF4B	100	75.614	ENSHGLG00100001656	-	98	75.753	Heterocephalus_glaber_male
ENSG00000063046	EIF4B	100	91.716	ENSHGLG00100000821	-	100	88.562	Heterocephalus_glaber_male
ENSG00000063046	EIF4B	100	97.041	ENSHGLG00100008532	-	99	95.552	Heterocephalus_glaber_male
ENSG00000063046	EIF4B	96	81.461	ENSHCOG00000010594	eif4bb	99	60.991	Hippocampus_comes
ENSG00000063046	EIF4B	96	79.775	ENSIPUG00000020173	EIF4B	99	56.968	Ictalurus_punctatus
ENSG00000063046	EIF4B	96	81.461	ENSIPUG00000006890	eif4b	100	62.344	Ictalurus_punctatus
ENSG00000063046	EIF4B	100	97.041	ENSSTOG00000006800	-	100	89.552	Ictidomys_tridecemlineatus
ENSG00000063046	EIF4B	96	96.610	ENSSTOG00000029945	-	100	91.980	Ictidomys_tridecemlineatus
ENSG00000063046	EIF4B	99	95.868	ENSJJAG00000021178	Eif4b	99	95.826	Jaculus_jaculus
ENSG00000063046	EIF4B	98	75.882	ENSKMAG00000001027	eif4bb	99	57.738	Kryptolebias_marmoratus
ENSG00000063046	EIF4B	94	78.652	ENSLBEG00000020534	eif4bb	99	56.344	Labrus_bergylta
ENSG00000063046	EIF4B	100	82.456	ENSLACG00000017403	EIF4B	99	64.006	Latimeria_chalumnae
ENSG00000063046	EIF4B	100	79.429	ENSLOCG00000005500	eif4ba	99	63.950	Lepisosteus_oculatus
ENSG00000063046	EIF4B	100	96.450	ENSLAFG00000009534	EIF4B	99	96.716	Loxodonta_africana
ENSG00000063046	EIF4B	98	98.649	ENSMFAG00000044995	-	100	93.781	Macaca_fascicularis
ENSG00000063046	EIF4B	100	85.207	ENSMFAG00000033728	-	96	85.165	Macaca_fascicularis
ENSG00000063046	EIF4B	100	98.214	ENSMFAG00000037195	-	100	98.214	Macaca_fascicularis
ENSG00000063046	EIF4B	100	96.916	ENSMMUG00000042124	-	100	93.617	Macaca_mulatta
ENSG00000063046	EIF4B	100	98.200	ENSMMUG00000001062	EIF4B	100	98.200	Macaca_mulatta
ENSG00000063046	EIF4B	98	84.114	ENSMMUG00000008391	-	100	84.124	Macaca_mulatta
ENSG00000063046	EIF4B	100	69.968	ENSMMUG00000038298	-	100	69.968	Macaca_mulatta
ENSG00000063046	EIF4B	100	95.858	ENSMMUG00000037830	-	100	98.206	Macaca_mulatta
ENSG00000063046	EIF4B	100	96.476	ENSMNEG00000043577	-	98	94.911	Macaca_nemestrina
ENSG00000063046	EIF4B	98	100.000	ENSMNEG00000029195	-	100	84.578	Macaca_nemestrina
ENSG00000063046	EIF4B	100	73.486	ENSMNEG00000034554	-	100	73.486	Macaca_nemestrina
ENSG00000063046	EIF4B	98	84.422	ENSMNEG00000040490	-	100	84.288	Macaca_nemestrina
ENSG00000063046	EIF4B	100	84.615	ENSMNEG00000041946	-	96	84.066	Macaca_nemestrina
ENSG00000063046	EIF4B	100	68.740	ENSMNEG00000027441	-	100	67.921	Macaca_nemestrina
ENSG00000063046	EIF4B	96	98.870	ENSMNEG00000028622	-	99	93.583	Macaca_nemestrina
ENSG00000063046	EIF4B	99	83.696	ENSMLEG00000006274	-	100	87.283	Mandrillus_leucophaeus
ENSG00000063046	EIF4B	100	90.308	ENSMLEG00000028830	-	93	90.217	Mandrillus_leucophaeus
ENSG00000063046	EIF4B	98	99.103	ENSMLEG00000023226	-	100	92.370	Mandrillus_leucophaeus
ENSG00000063046	EIF4B	100	97.633	ENSMLEG00000033967	-	98	95.051	Mandrillus_leucophaeus
ENSG00000063046	EIF4B	95	78.125	ENSMLEG00000024919	-	99	69.847	Mandrillus_leucophaeus
ENSG00000063046	EIF4B	100	74.286	ENSMAMG00000016889	eif4bb	98	55.178	Mastacembelus_armatus
ENSG00000063046	EIF4B	96	79.775	ENSMZEG00005026975	eif4bb	99	49.493	Maylandia_zebra
ENSG00000063046	EIF4B	83	85.811	ENSMGAG00000005127	-	100	86.164	Meleagris_gallopavo
ENSG00000063046	EIF4B	100	96.450	ENSMAUG00000018343	Eif4b	99	93.311	Mesocricetus_auratus
ENSG00000063046	EIF4B	92	83.851	ENSMAUG00000014007	-	94	75.330	Mesocricetus_auratus
ENSG00000063046	EIF4B	100	86.808	ENSMICG00000033942	-	100	85.505	Microcebus_murinus
ENSG00000063046	EIF4B	98	72.646	ENSMICG00000035704	-	100	70.385	Microcebus_murinus
ENSG00000063046	EIF4B	100	96.753	ENSMICG00000033915	-	99	98.143	Microcebus_murinus
ENSG00000063046	EIF4B	98	91.031	ENSMOCG00000017700	-	100	88.543	Microtus_ochrogaster
ENSG00000063046	EIF4B	100	95.858	ENSMOCG00000015277	-	100	93.781	Microtus_ochrogaster
ENSG00000063046	EIF4B	98	87.892	ENSMOCG00000018841	-	100	84.463	Microtus_ochrogaster
ENSG00000063046	EIF4B	100	94.083	ENSMOCG00000006053	-	97	90.349	Microtus_ochrogaster
ENSG00000063046	EIF4B	96	95.480	ENSMOCG00000012575	-	99	94.475	Microtus_ochrogaster
ENSG00000063046	EIF4B	100	74.138	ENSMMOG00000004246	eif4bb	99	55.309	Mola_mola
ENSG00000063046	EIF4B	100	74.138	ENSMALG00000021976	eif4bb	92	77.143	Monopterus_albus
ENSG00000063046	EIF4B	98	97.309	MGP_CAROLIEiJ_G0020335	Eif4b	100	95.090	Mus_caroli
ENSG00000063046	EIF4B	98	97.309	ENSMUSG00000058655	Eif4b	100	97.519	Mus_musculus
ENSG00000063046	EIF4B	98	97.309	MGP_SPRETEiJ_G0021228	Eif4b	100	94.108	Mus_spretus
ENSG00000063046	EIF4B	100	97.633	ENSMPUG00000006220	EIF4B	100	95.425	Mustela_putorius_furo
ENSG00000063046	EIF4B	100	95.266	ENSMLUG00000013021	EIF4B	100	94.951	Myotis_lucifugus
ENSG00000063046	EIF4B	100	95.858	ENSNGAG00000012353	Eif4b	100	95.745	Nannospalax_galili
ENSG00000063046	EIF4B	99	77.246	ENSNGAG00000006827	-	100	77.348	Nannospalax_galili
ENSG00000063046	EIF4B	96	80.337	ENSNBRG00000015331	eif4bb	100	59.815	Neolamprologus_brichardi
ENSG00000063046	EIF4B	98	75.758	ENSNLEG00000035400	-	95	72.089	Nomascus_leucogenys
ENSG00000063046	EIF4B	100	98.539	ENSNLEG00000017727	EIF4B	100	98.539	Nomascus_leucogenys
ENSG00000063046	EIF4B	100	81.065	ENSNLEG00000027255	-	93	85.714	Nomascus_leucogenys
ENSG00000063046	EIF4B	100	95.858	ENSOPRG00000008447	EIF4B	99	94.901	Ochotona_princeps
ENSG00000063046	EIF4B	100	95.266	ENSODEG00000012941	-	98	86.167	Octodon_degus
ENSG00000063046	EIF4B	98	82.960	ENSODEG00000011370	-	100	80.574	Octodon_degus
ENSG00000063046	EIF4B	96	80.899	ENSONIG00000019380	eif4bb	99	59.014	Oreochromis_niloticus
ENSG00000063046	EIF4B	99	86.413	ENSOANG00000009940	-	100	69.435	Ornithorhynchus_anatinus
ENSG00000063046	EIF4B	59	94.000	ENSOANG00000028937	-	57	92.661	Ornithorhynchus_anatinus
ENSG00000063046	EIF4B	100	97.041	ENSOCUG00000013484	EIF4B	93	93.813	Oryctolagus_cuniculus
ENSG00000063046	EIF4B	98	73.256	ENSORLG00000016502	eif4bb	99	57.751	Oryzias_latipes
ENSG00000063046	EIF4B	98	73.256	ENSORLG00015008020	eif4bb	99	57.571	Oryzias_latipes_hsok
ENSG00000063046	EIF4B	98	75.269	ENSOMEG00000000454	eif4bb	99	56.138	Oryzias_melastigma
ENSG00000063046	EIF4B	100	96.450	ENSOARG00000016759	EIF4B	100	95.942	Ovis_aries
ENSG00000063046	EIF4B	100	95.858	ENSPPAG00000029220	-	87	94.619	Pan_paniscus
ENSG00000063046	EIF4B	95	95.031	ENSPPAG00000043040	-	96	89.506	Pan_paniscus
ENSG00000063046	EIF4B	97	71.380	ENSPPAG00000030041	-	98	70.202	Pan_paniscus
ENSG00000063046	EIF4B	95	85.093	ENSPPAG00000038159	-	96	76.871	Pan_paniscus
ENSG00000063046	EIF4B	98	99.103	ENSPPAG00000029383	-	94	99.661	Pan_paniscus
ENSG00000063046	EIF4B	98	99.103	ENSPPAG00000030546	-	95	99.485	Pan_paniscus
ENSG00000063046	EIF4B	100	97.565	ENSPPRG00000008730	EIF4B	100	97.565	Panthera_pardus
ENSG00000063046	EIF4B	100	97.565	ENSPTIG00000014635	EIF4B	100	97.565	Panthera_tigris_altaica
ENSG00000063046	EIF4B	100	90.835	ENSPTRG00000043454	-	100	90.835	Pan_troglodytes
ENSG00000063046	EIF4B	98	99.103	ENSPTRG00000043800	-	100	96.727	Pan_troglodytes
ENSG00000063046	EIF4B	100	95.266	ENSPTRG00000040264	-	100	94.926	Pan_troglodytes
ENSG00000063046	EIF4B	100	90.835	ENSPTRG00000050351	-	100	90.835	Pan_troglodytes
ENSG00000063046	EIF4B	100	99.675	ENSPTRG00000047145	-	100	99.675	Pan_troglodytes
ENSG00000063046	EIF4B	95	86.335	ENSPTRG00000049274	-	98	76.923	Pan_troglodytes
ENSG00000063046	EIF4B	100	91.716	ENSPTRG00000043521	-	100	92.995	Pan_troglodytes
ENSG00000063046	EIF4B	100	98.864	ENSPANG00000014458	-	100	98.864	Papio_anubis
ENSG00000063046	EIF4B	100	98.678	ENSPANG00000005737	-	97	98.454	Papio_anubis
ENSG00000063046	EIF4B	95	78.750	ENSPANG00000034874	-	100	73.077	Papio_anubis
ENSG00000063046	EIF4B	100	89.427	ENSPANG00000029637	-	96	88.889	Papio_anubis
ENSG00000063046	EIF4B	100	83.432	ENSPANG00000033749	-	99	84.305	Papio_anubis
ENSG00000063046	EIF4B	99	77.907	ENSPKIG00000015805	eif4ba	93	65.649	Paramormyrops_kingsleyae
ENSG00000063046	EIF4B	100	92.398	ENSPSIG00000017738	EIF4B	81	81.586	Pelodiscus_sinensis
ENSG00000063046	EIF4B	99	79.891	ENSPMGG00000022372	eif4bb	96	79.891	Periophthalmus_magnuspinnatus
ENSG00000063046	EIF4B	100	96.450	ENSPEMG00000016399	Eif4b	100	89.338	Peromyscus_maniculatus_bairdii
ENSG00000063046	EIF4B	99	62.791	ENSPMAG00000005484	EIF4B	98	48.237	Petromyzon_marinus
ENSG00000063046	EIF4B	97	64.535	ENSPMAG00000005947	-	98	49.885	Petromyzon_marinus
ENSG00000063046	EIF4B	100	94.737	ENSPCIG00000011212	EIF4B	100	89.194	Phascolarctos_cinereus
ENSG00000063046	EIF4B	96	80.899	ENSPFOG00000002142	eif4bb	99	59.969	Poecilia_formosa
ENSG00000063046	EIF4B	96	80.337	ENSPLAG00000018434	eif4bb	99	59.509	Poecilia_latipinna
ENSG00000063046	EIF4B	98	77.193	ENSPMEG00000003502	eif4bb	98	59.601	Poecilia_mexicana
ENSG00000063046	EIF4B	96	81.461	ENSPREG00000001769	eif4bb	99	59.724	Poecilia_reticulata
ENSG00000063046	EIF4B	100	99.345	ENSPPYG00000025848	EIF4B	100	99.345	Pongo_abelii
ENSG00000063046	EIF4B	81	99.074	ENSPCAG00000001759	EIF4B	81	99.074	Procavia_capensis
ENSG00000063046	EIF4B	85	92.361	ENSPCOG00000016096	-	100	84.404	Propithecus_coquereli
ENSG00000063046	EIF4B	100	97.078	ENSPCOG00000007039	-	100	97.078	Propithecus_coquereli
ENSG00000063046	EIF4B	100	96.399	ENSPVAG00000009362	EIF4B	100	96.399	Pteropus_vampyrus
ENSG00000063046	EIF4B	96	80.337	ENSPNYG00000006114	eif4bb	99	49.568	Pundamilia_nyererei
ENSG00000063046	EIF4B	96	79.213	ENSPNAG00000013294	eif4bb	100	56.054	Pygocentrus_nattereri
ENSG00000063046	EIF4B	100	77.011	ENSPNAG00000006684	eif4ba	100	61.705	Pygocentrus_nattereri
ENSG00000063046	EIF4B	100	95.858	ENSRNOG00000010103	Eif4b	100	95.745	Rattus_norvegicus
ENSG00000063046	EIF4B	96	87.006	ENSRBIG00000032876	-	100	75.921	Rhinopithecus_bieti
ENSG00000063046	EIF4B	89	89.404	ENSRBIG00000038114	-	91	72.388	Rhinopithecus_bieti
ENSG00000063046	EIF4B	100	81.997	ENSRBIG00000024635	-	98	83.788	Rhinopithecus_bieti
ENSG00000063046	EIF4B	100	98.703	ENSRBIG00000043823	-	100	98.703	Rhinopithecus_bieti
ENSG00000063046	EIF4B	100	98.377	ENSRROG00000033336	-	100	98.377	Rhinopithecus_roxellana
ENSG00000063046	EIF4B	100	75.974	ENSRROG00000044158	-	100	75.974	Rhinopithecus_roxellana
ENSG00000063046	EIF4B	100	99.119	ENSRROG00000028884	-	97	99.119	Rhinopithecus_roxellana
ENSG00000063046	EIF4B	98	85.403	ENSRROG00000045254	-	99	85.403	Rhinopithecus_roxellana
ENSG00000063046	EIF4B	89	90.000	ENSRROG00000030278	-	96	79.048	Rhinopithecus_roxellana
ENSG00000063046	EIF4B	96	87.006	ENSRROG00000034314	-	88	84.091	Rhinopithecus_roxellana
ENSG00000063046	EIF4B	100	98.363	ENSSBOG00000026444	EIF4B	100	98.363	Saimiri_boliviensis_boliviensis
ENSG00000063046	EIF4B	95	79.375	ENSSBOG00000032333	-	98	66.388	Saimiri_boliviensis_boliviensis
ENSG00000063046	EIF4B	99	71.579	ENSSBOG00000024773	-	83	71.579	Saimiri_boliviensis_boliviensis
ENSG00000063046	EIF4B	100	94.152	ENSSHAG00000003682	EIF4B	100	89.015	Sarcophilus_harrisii
ENSG00000063046	EIF4B	96	76.271	ENSSFOG00015018808	EIF4B	99	55.485	Scleropages_formosus
ENSG00000063046	EIF4B	99	77.326	ENSSFOG00015016223	EIF4B	91	66.182	Scleropages_formosus
ENSG00000063046	EIF4B	100	71.839	ENSSMAG00000007678	eif4bb	99	55.821	Scophthalmus_maximus
ENSG00000063046	EIF4B	96	82.022	ENSSDUG00000022993	eif4bb	99	58.309	Seriola_dumerili
ENSG00000063046	EIF4B	96	82.022	ENSSLDG00000010210	eif4bb	99	58.112	Seriola_lalandi_dorsalis
ENSG00000063046	EIF4B	98	87.646	ENSSARG00000000838	EIF4B	99	87.685	Sorex_araneus
ENSG00000063046	EIF4B	100	87.719	ENSSPUG00000017451	EIF4B	100	74.189	Sphenodon_punctatus
ENSG00000063046	EIF4B	100	74.286	ENSSPAG00000003105	eif4bb	99	57.463	Stegastes_partitus
ENSG00000063046	EIF4B	100	97.041	ENSSSCG00000032028	-	100	96.072	Sus_scrofa
ENSG00000063046	EIF4B	100	85.465	ENSTGUG00000003829	EIF4B	100	76.998	Taeniopygia_guttata
ENSG00000063046	EIF4B	98	66.667	ENSTRUG00000019563	eif4bb	89	65.000	Takifugu_rubripes
ENSG00000063046	EIF4B	96	76.966	ENSTNIG00000007192	eif4bb	100	57.609	Tetraodon_nigroviridis
ENSG00000063046	EIF4B	94	98.276	ENSTBEG00000005423	EIF4B	73	98.780	Tupaia_belangeri
ENSG00000063046	EIF4B	96	97.740	ENSTTRG00000002770	EIF4B	63	97.740	Tursiops_truncatus
ENSG00000063046	EIF4B	90	89.350	ENSUAMG00000017022	EIF4B	96	89.350	Ursus_americanus
ENSG00000063046	EIF4B	100	97.633	ENSUMAG00000009372	EIF4B	100	96.569	Ursus_maritimus
ENSG00000063046	EIF4B	97	96.089	ENSVPAG00000007999	EIF4B	100	92.635	Vicugna_pacos
ENSG00000063046	EIF4B	99	86.364	ENSVVUG00000016220	-	99	86.364	Vulpes_vulpes
ENSG00000063046	EIF4B	100	90.749	ENSVVUG00000000336	-	87	93.119	Vulpes_vulpes
ENSG00000063046	EIF4B	100	98.286	ENSVVUG00000028016	-	100	98.286	Vulpes_vulpes
ENSG00000063046	EIF4B	100	88.953	ENSXETG00000001829	eif4b	99	67.460	Xenopus_tropicalis
ENSG00000063046	EIF4B	96	76.966	ENSXCOG00000017714	eif4bb	99	57.098	Xiphophorus_couchianus
ENSG00000063046	EIF4B	96	81.461	ENSXMAG00000018673	eif4bb	99	59.480	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001731	formation of translation preinitiation complex	21873635.	IBA	Process
GO:0002181	cytoplasmic translation	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003743	translation initiation factor activity	21873635.	IBA	Function
GO:0005515	protein binding	21044950.21887822.	IPI	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005844	polysome	21873635.	IBA	Component
GO:0006413	translational initiation	-	TAS	Process
GO:0006446	regulation of translational initiation	2390971.	TAS	Process
GO:0016281	eukaryotic translation initiation factor 4F complex	2390971.	TAS	Component
GO:0033592	RNA strand annealing activity	21873635.	IBA	Function
GO:0034057	RNA strand-exchange activity	21873635.	IBA	Function
GO:0043024	ribosomal small subunit binding	21873635.	IBA	Function
GO:0097010	eukaryotic translation initiation factor 4F complex assembly	21873635.	IBA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.