EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr10	124401731	Missense_Mutation	novel	L337F	0.17
BRCA	chr10	124401751	Missense_Mutation	novel	C330Y	0.39
BRCA	chr10	124408855	Missense_Mutation	NA	Q104E	0.13
CESC	chr10	124403891	Silent	novel	A226A	0.44
CESC	chr10	124398017	Silent	rs751449034	A415A	0.42
CESC	chr10	124400888	Missense_Mutation	rs763064048	V371I	0.49
CESC	chr10	124400919	Silent	rs375458030	L360L	0.07
COAD	chr10	124398082	Missense_Mutation	rs121965054	C394R	0.24
COAD	chr10	124405646	Intron	novel		0.16
COAD	chr10	124412075	Frame_Shift_Del	NA	*T33Qfs28**	0.19
COAD	chr10	124403829	Missense_Mutation	rs140966644	M247T	0.41
COAD	chr10	124397823	3'UTR	novel		0.32
COAD	chr10	124398012	Missense_Mutation	rs121965044	P417L	0.45
COAD	chr10	124405627	Intron	NA		0.28
COAD	chr10	124398074	Silent	NA	R396R	0.12
ESCA	chr10	124408589	Missense_Mutation	novel	Y158C	0.29
ESCA	chr10	124405589	Intron	novel		0.31
ESCA	chr10	124408859	Silent	novel	K102K	0.41
GBM	chr10	124412025	Missense_Mutation	novel	K49N	0.04
GBM	chr10	124403881	Nonsense_Mutation	novel	E230*	0.26
GBM	chr10	124397875	3'UTR	novel		0.25
KIRC	chr10	124408955	Frame_Shift_Del	novel	*L70Gfs3**	0.15
KIRP	chr10	124405616	Intron	novel		0.63
KIRP	chr10	124408768	Missense_Mutation	novel	Y133H	0.26
KIRP	chr10	124412075	Frame_Shift_Del	NA	*T33Qfs28**	0.36
LAML	chr10	124401742	Missense_Mutation	novel	A333V	0.06
LGG	chr10	124405436	Missense_Mutation	novel	E216D	0.12
LIHC	chr10	124412124	Silent	rs143526711	R16R	0.46
LIHC	chr10	124403806	Missense_Mutation	NA	R255W	0.25
LIHC	chr10	124400916	Missense_Mutation	NA	M361I	0.21
LUAD	chr10	124412105	Missense_Mutation	NA	A23S	0.67
LUAD	chr10	124403006	Missense_Mutation	novel	R274K	0.04
LUAD	chr10	124400912	Missense_Mutation	novel	L363V	0.24
LUAD	chr10	124405626	Intron	novel		0.45
LUSC	chr10	124397944	Nonstop_Mutation	novel	440Rext2	0.56
LUSC	chr10	124408966	Splice_Site	NA	X67_splice	0.31
LUSC	chr10	124405477	Nonsense_Mutation	NA	G203*	0.28
LUSC	chr10	124398085	Frame_Shift_Del	novel	*V393Cfs27**	0.11
OV	chr10	124403055	Missense_Mutation	novel	V258F	0.06
OV	chr10	124405553	Silent	novel	F177F	0.1
OV	chr10	124397911	3'UTR	novel		0.3
OV	chr10	124402931	Missense_Mutation	novel	Y299F	0.05
PAAD	chr10	124405444	Missense_Mutation	novel	A214T	0.09
PAAD	chr10	124411985	Nonsense_Mutation	novel	E63*	0.19
READ	chr10	124412075	Frame_Shift_Del	NA	*T33Qfs28**	0.45
READ	chr10	124400977	Missense_Mutation	NA	E341G	0.13
SKCM	chr10	124401728	Missense_Mutation	NA	E338K	0.22
SKCM	chr10	124403812	Missense_Mutation	NA	C253R	0.27
SKCM	chr10	124401805	Missense_Mutation	NA	L312P	0.16
SKCM	chr10	124408824	Missense_Mutation	NA	A114V	0.44
SKCM	chr10	124405572	Intron	novel		0.43
SKCM	chr10	124403847	Missense_Mutation	rs121965051	P241L	0.22
SKCM	chr10	124398089	Missense_Mutation	novel	W391C	0.59
SKCM	chr10	124400893	Missense_Mutation	NA	T369I	0.35
SKCM	chr10	124401731	Missense_Mutation	novel	L337F	0.53
SKCM	chr10	124405572	Intron	novel		0.9
SKCM	chr10	124405573	Intron	novel		0.9
STAD	chr10	124397823	3'UTR	novel		0.29
STAD	chr10	124412075	Frame_Shift_Del	NA	*T33Qfs28**	0.27
STAD	chr10	124408579	Silent	NA	K161K	0.28
STAD	chr10	124397932	3'UTR	novel		0.47
STAD	chr10	124400888	Missense_Mutation	rs763064048	V371I	0.35
STAD	chr10	124408859	Silent	novel	K102K	0.46
STAD	chr10	124397823	3'UTR	novel		0.5
STAD	chr10	124401769	Missense_Mutation	NA	G324A	0.46
STAD	chr10	124397888	3'UTR	novel		0.18
UCEC	chr10	124401737	Missense_Mutation	rs751075605	A335T	0.6
UCEC	chr10	124397785	3'UTR	rs778411980		0.38
UCEC	chr10	124398023	Silent	novel	R413R	0.35
UCEC	chr10	124398069	Missense_Mutation	NA	R398Q	0.42
UCEC	chr10	124408877	Missense_Mutation	NA	K96N	0.35
UCEC	chr10	124405590	Intron	novel		0.4
UCEC	chr10	124408908	Missense_Mutation	novel	S86N	0.44
UCEC	chr10	124398012	Missense_Mutation	NA	P417Q	0.27
UCEC	chr10	124403037	Nonsense_Mutation	novel	E264*	0.29
UCEC	chr10	124405502	Silent	rs754489812	Y194Y	0.31
UCEC	chr10	124398069	Missense_Mutation	NA	R398Q	0.19
UCEC	chr10	124400888	Missense_Mutation	rs763064048	V371I	0.35
UCEC	chr10	124398017	Silent	rs751449034	A415A	0.11
UCEC	chr10	124401775	Missense_Mutation	novel	T322I	0.11
UCEC	chr10	124403019	Missense_Mutation	novel	A270T	0.24
UCEC	chr10	124397823	3'UTR	novel		0.45
UCEC	chr10	124397964	Missense_Mutation	novel	N433S	0.36
UCEC	chr10	124405689	Intron	novel		0.29
UCEC	chr10	124405541	Silent	rs558611630	T181T	0.49
UCEC	chr10	124408891	Missense_Mutation	novel	H92Y	0.48
UCEC	chr10	124412201	Splice_Site	novel		0.33
UCEC	chr10	124401738	Silent	rs757744354	I334I	0.53
UCEC	chr10	124408859	Missense_Mutation	novel	K102N	0.34
UCEC	chr10	124400981	Missense_Mutation	NA	L340V	0.29
UCEC	chr10	124402967	Missense_Mutation	rs550949287	I287T	0.31
UCEC	chr10	124400929	Missense_Mutation	novel	R357I	0.13
UCEC	chr10	124408952	Nonsense_Mutation	novel	W71*	0.33
UCEC	chr10	124400849	Nonsense_Mutation	novel	E384*	0.06
UCEC	chr10	124401753	Silent	novel	G329G	0.07
UCEC	chr10	124408630	Missense_Mutation	novel	E144D	0.05
UCEC	chr10	124408957	Silent	NA	L70L	0.41
UCEC	chr10	124408810	Missense_Mutation	rs150939128	V119I	0.49
UCEC	chr10	124397786	3'UTR	novel		0.2
UCEC	chr10	124408602	Missense_Mutation	rs1804030	R154C	0.51
UCEC	chr10	124411974	Missense_Mutation	novel	K66N	0.19
UCEC	chr10	124412191	5'UTR	novel		0.43
UCEC	chr10	124397756	3'UTR	rs186070660		0.26

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1111	0.19593
CHOL	DEL	0.2222	0.048655
COAD	DEL	0.1574	9.4741e-07
LGG	DEL	0.2632	4.3789e-20
LIHC	DEL	0.2405	5.7505e-06
MESO	DEL	0.2644	0.00015289
PAAD	DEL	0.1141	0.169
READ	DEL	0.2061	0.014135
THYM	DEL	0.0325	0.10563
UCS	DEL	0.25	0.1218

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0053	Kaplan-Meier Survival Analysis
ACC	0.0075	Kaplan-Meier Survival Analysis
UCS	0.0073	Kaplan-Meier Survival Analysis
LUSC	0.027	Kaplan-Meier Survival Analysis
BLCA	0.031	Kaplan-Meier Survival Analysis
UCEC	0.029	Kaplan-Meier Survival Analysis
LUAD	0.0085	Kaplan-Meier Survival Analysis
UVM	0.0015	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000065154 (Gene tree)
Gene ID: 4942
Gene Symbol: OAT
Alias: HOGA
Full Name: ornithine aminotransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 21,674 bases
Position: chr10:124,397,303-124,418,976
Accession: 8091
RBP type: non-canonical RBP
Summary: This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000492376	OAT-207	620	-	-	- (aa)	-	-
ENST00000539214	OAT-208	1864	XM_017016279	ENSP00000439042	301 (aa)	XP_016871768	P04181
ENST00000490096	OAT-206	579	-	-	- (aa)	-	-
ENST00000471127	OAT-203	751	-	-	- (aa)	-	-
ENST00000476917	OAT-204	646	-	-	- (aa)	-	-
ENST00000483711	OAT-205	570	-	-	- (aa)	-	-
ENST00000467675	OAT-202	810	-	-	- (aa)	-	-
ENST00000368845	OAT-201	2048	-	ENSP00000357838	439 (aa)	-	P04181

Gene Model

Click here to download ENSG00000065154's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00330	Arginine and proline metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000065154's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000065154	OAT	99	52.698	YLR438W	CAR2	98	53.012	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004587	ornithine-oxo-acid transaminase activity	21873635.	IBA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0007601	visual perception	2793865.	TAS	Process
GO:0008652	cellular amino acid biosynthetic process	-	TAS	Process
GO:0010121	arginine catabolic process to proline via ornithine	21873635.	IBA	Process
GO:0019544	arginine catabolic process to glutamate	21873635.	IBA	Process
GO:0030170	pyridoxal phosphate binding	21873635.	IBA	Function
GO:0034214	protein hexamerization	9514741.	IDA	Process
GO:0055129	L-proline biosynthetic process	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.