EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15328200	Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma.	Clin Cancer Res	2004 Aug 15	Denkert C	-
19875930	MicroRNA-125a represses cell growth by targeting HuR in breast cancer.	RNA Biol	2009 Nov-Dec	Guo X	-
21152064	pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs.	PLoS One	2010 Nov 29	Williams TK	doi: 10.1371/journal.pone.0015455.
30226552	Decreased human antigenR expression confers resistance totyrosine kinase inhibitors in epidermal growth factor receptor-mutant lung cancer by inhibiting Bim expression.	Int J Mol Med	2018 Nov	Yao Y	doi: 10.3892/ijmm.2018.3835
17581403	Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical carcinoma.	Int J Gynecol Pathol	2007 Jul	Lim SJ	-
18641687	Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.	Oncogene	2008 Oct 16	Mazan-Mamczarz K	doi: 10.1038/onc.2008.215
23901138	miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR.	Sci Signal	2013 Jul 30	Balkhi MY	doi: 10.1126/scisignal.2004177.
22095636	Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.	Hepatology	2012 Apr	Embade N	doi: 10.1002/hep.24795
21310943	High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells.	Carcinogenesis	2011 May	Doller A	doi: 10.1093/carcin/bgr024
20724828	Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis.	Cell Cycle	2010 Aug 15	Gubin MM	doi: 10.4161/cc.9.16.12711
23873103	Cytoplasmic expression of the ELAV-like protein HuR as a potential prognostic marker in esophageal squamous cell carcinoma.	Tumour Biol	2014 Jan	Zhang C	doi: 10.1007/s13277-013-1008-4
18831511	Expression of the embryonic lethal abnormal vision-like protein HuR in human mesothelioma: association with cyclooxygenase-2 and prognosis.	Cancer	2008 Nov 15	Stoppoloni D	doi: 10.1002/cncr.23904.
26434587	Negative regulation of RNA-binding protein HuR by tumor-suppressor ECRG2.	Oncogene	2016 May 19	Lucchesi C	doi: 10.1038/onc.2015.339
28790173	Hu antigen R (HuR) multimerization contributes to glioma disease progression.	J Biol Chem	2017 Oct 13	Filippova N	doi: 10.1074/jbc.M117.797878
26943573	Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy.	Oncotarget	2016 Apr 19	Huang YH	doi: 10.18632/oncotarget.7840.
28242812	CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype.	Mol Cancer Res	2017 Jun	Lal S	doi: 10.1158/1541-7786.MCR-16-0361
29344850	HuR facilitates cancer stemness of lung cancer cells via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis.	Biotechnol Lett	2018 Apr	Zhang Y	doi: 10.1007/s10529-018-2512-9
29597092	Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents.	Biomed Pharmacother	2018 Jun	Xu W	doi: 10.1016/j.biopha.2018.03.098
18824170	NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis.	Gastroenterology	2008 Dec	Kang MJ	doi: 10.1053/j.gastro.2008.08.009
27328938	Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration.	J Nanobiotechnology	2016 Jun 21	Muralidharan R	doi: 10.1186/s12951-016-0201-1.
20370918	The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer.	BMC Cancer	2010 Apr 6	Calaluce R	doi: 10.1186/1471-2407-10-126.
28851919	Human antigen R-regulated CCL20 contributes to osteolytic breast cancer bone metastasis.	Sci Rep	2017 Aug 29	Lee SK	doi: 10.1038/s41598-017-09040-4.
23401122	miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer.	J Pathol	2013 May	Al-Ahmadi W	doi: 10.1002/path.4178
23605320	Cytoplasmic HuR expression correlates with P-gp, HER-2 positivity, and poor outcome in breast cancer.	Tumour Biol	2013 Aug	Zhu Z	doi: 10.1007/s13277-013-0774-3
25841271	NEDDylation in liver cancer: The regulation of the RNA binding protein Hu antigen R.	Pancreatology	2015 Jul	Fern??ndez-Ramos D	doi: 10.1016/j.pan.2015.03.006
26675757	HuR mediated post-transcriptional regulation as a new potential adjuvant therapeutic target in chemotherapy for pancreatic cancer.	World J Gastroenterol	2015 Dec 14	Jakstaite A	doi: 10.3748/wjg.v21.i46.13004.
20960565	Association between expression of embryonic lethal abnormal vision-like protein HuR and cyclooxygenase-2 in oral squamous cell carcinoma.	Head Neck	2011 May	Cha JD	doi: 10.1002/hed.21507
21935886	Posttranscriptional regulation of cancer traits by HuR.	Wiley Interdiscip Rev RNA	2010 Sep-Oct	Abdelmohsen K	doi: 10.1002/wrna.4
25534855	HuR represses Wnt/β-catenin-mediated transcriptional activity by promoting cytoplasmic localization of β-catenin.	Biochem Biophys Res Commun	2015 Jan 30	Kim I	doi: 10.1016/j.bbrc.2014.12.052
24260469	Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia.	PLoS One	2013 Nov 15	D'Uva G	doi: 10.1371/journal.pone.0080742
22921787	Cancer cell growth suppression by a 62nt AU-rich RNA from C/EBPβ 3'UTR through competitive binding with HuR.	Biochem Biophys Res Commun	2012 Sep 14	Sun DQ	doi: 10.1016/j.bbrc.2012.08.049
20626035	Loss of repression of HuR translation by miR-16 may be responsible for the elevation of HuR in human breast carcinoma.	J Cell Biochem	2010 Oct 15	Xu F	doi: 10.1002/jcb.22762.
27215092	MiR-31 Functions as a Tumor Suppressor in Lung Adenocarcinoma Mainly by Targeting HuR.	Clin Lab	2016	Xu H	-
22907529	Genetic polymorphisms in RNA binding proteins contribute to breast cancer survival.	Int J Cancer	2013 Feb 1	Upadhyay R	doi: 10.1002/ijc.27789
19281587	HuR expression in the nucleus correlates with high histological grade and poor disease-free survival in ovarian cancer.	Aust N Z J Obstet Gynaecol	2009 Feb	Yi X	doi: 10.1111/j.1479-828X.2008.00937.x.
26692264	Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins.	PLoS One	2015 Dec 21	de Sousa GF	doi: 10.1371/journal.pone.0145377
16912169	HuR contributes to cyclin E1 deregulation in MCF-7 breast cancer cells.	Cancer Res	2006 Aug 15	Guo X	-
26498465	Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions.	Pathol Oncol Res	2016 Jan	Giaginis C	-
19010922	Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR.	Cancer Res	2008 Nov 15	Saunus JM	doi: 10.1158/0008-5472.CAN-08-1159.
23516604	High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer.	PLoS One	2013	Miyata Y	doi: 10.1371/journal.pone.0059095
25706256	Targeting the multifaceted HuR protein, benefits and caveats.	Curr Drug Targets	2015	Zucal C	-
14562043	Role of the RNA-binding protein HuR in colon carcinogenesis.	Oncogene	2003 Oct 16	L??pez de Silanes I	-
19420963	The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis.	Oncology	2009	Wang J	doi: 10.1159/000216837
18769129	Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells.	Cancer Biol Ther	2008 Sep	Hostetter C	-
12011088	Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA.	J Biol Chem	2002 Jul 26	Yeap BB	-
26764246	Cytoplasmic accumulation of ELAVL1 is an independent predictor of biochemical recurrence associated with genomic instability in prostate cancer.	Prostate	2016 Feb 15	Melling N	doi: 10.1002/pros.23120
21503589	Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9.	Oncol Rep	2011 Jul	Yuan Z	doi: 10.3892/or.2011.1271
25252849	Hu-antigen receptor (HuR) and cyclooxygenase-2 (COX-2) expression in human non-small-cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival.	Tumour Biol	2015 Jan	Giaginis C	doi: 10.1007/s13277-014-2637-y
21273615	Prognostic value of the human antigen R (HuR) in human breast cancer: high level predicts a favourable prognosis.	Anticancer Res	2011 Jan	Yuan Z	-
19151756	Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer.	Oncogene	2009 Mar 5	Woo HH	doi: 10.1038/onc.2008.469
17132932	HuR: post-transcriptional paths to malignancy.	RNA Biol	2005 Jan	L??pez de Silanes I	-
21795698	Caspase-mediated cleavage of RNA-binding protein HuR regulates c-Myc protein expression after hypoxic stress.	J Biol Chem	2011 Sep 16	Talwar S	doi: 10.1074/jbc.M111.255927
24954509	HSF1 regulation of β-catenin in mammary cancer cells through control of HuR/elavL1 expression.	Oncogene	2015 Apr 23	Chou SD	doi: 10.1038/onc.2014.177
20332213	HuR knockdown changes the oncogenic potential of oral cancer cells.	Mol Cancer Res	2010 Apr	Kakuguchi W	doi: 10.1158/1541-7786.MCR-09-0367
24036660	Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy.	Breast Cancer Res Treat	2013 Sep	Wang J	doi: 10.1007/s10549-013-2679-7
23394580	MiR-200c and HuR in ovarian cancer.	BMC Cancer	2013 Feb 8	Prislei S	doi: 10.1186/1471-2407-13-72.
27784781	Autotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1.	J Biol Chem	2016 Dec 9	Sun S	-
28371600	HuR Stabilizes lnc-Sox5 mRNA to Promote Tongue Carcinogenesis.	Biochemistry (Mosc)	2017 Apr	Wang L	doi: 10.1134/S0006297917040046.
27140699	Human antigen R is positively associated with malignant aggressiveness via upregulation of cell proliferation, migration, and vascular endothelial growth factors and cyclooxygenase-2 in prostate cancer.	Transl Res	2016 Sep	Mitsunari K	doi: 10.1016/j.trsl.2016.04.002
28637868	Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells.	J Biol Chem	2017 Aug 18	Tan S	doi: 10.1074/jbc.M117.780973
28965949	Adrenaline promotes epithelial-to-mesenchymal transition via HuR-TGFβ regulatory axis in pancreatic cancer cells and the implication in cancer prognosis.	Biochem Biophys Res Commun	2017 Nov 25	Pu J	doi: 10.1016/j.bbrc.2017.09.146
27588488	HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy.	Oncotarget	2016 Oct 4	Mehta M	doi: 10.18632/oncotarget.11706.
27542231	Identification of tumorigenesis-related mRNAs associated with RNA-binding protein HuR in thyroid cancer cells.	Oncotarget	2016 Sep 27	Baldan F	doi: 10.18632/oncotarget.11255.
28501005	HuR promotes breast cancer cell proliferation and survival via binding to CDK3 mRNA.	Biomed Pharmacother	2017 Jul	Zhang Z	doi: 10.1016/j.biopha.2017.04.063
29758295	Systematic bioinformatic approaches reveal novel gene expression signatures associated with acquired resistance to EGFR targeted therapy in lung cancer.	Gene	2018 Aug 15	Mojtabavi Naeini M	doi: 10.1016/j.gene.2018.04.077
29566946	High cytoplasmic HuR expression is associated with advanced pT stage, high grade and increased microvessel density in urothelial bladder carcinoma.	Ann Diagn Pathol	2018 Apr	Fus P	doi: 10.1016/j.anndiagpath.2017.12.002
30670910	Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer.	World J Gastroenterol	2019 Jan 14	Lukosiute-Urboniene A	doi: 10.3748/wjg.v25.i2.205.
30664176	Interaction between C2ORF68 and HuR in human colorectal cancer.	Oncol Rep	2019 Mar	Lv Z	doi: 10.3892/or.2019.6973

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	8390497	Intron	novel		0.31
BLCA	chr19	7991832	Splice_Region	NA		0.18
BLCA	chr19	7981155	Silent	rs767301210	Y68Y	0.23
BLCA	chr19	7973734	Nonsense_Mutation	novel	Q141*	0.21
BLCA	chr19	7973798	Missense_Mutation	novel	Q119H	0.19
BLCA	chr19	7967571	Missense_Mutation	NA	R217T	0.23
BLCA	chr19	7963549	Silent	novel	L305L	0.12
BLCA	chr19	7973846	Missense_Mutation	novel	I103M	0.43
BLCA	chr19	7973856	Nonsense_Mutation	novel	S100*	0.56
BLCA	chr19	7973847	Frame_Shift_Ins	novel	*I103Nfs53**	0.32
BLCA	chr19	7973849	Silent	novel	V102V	0.3
BLCA	chr19	7973798	Silent	novel	Q119Q	0.2
BRCA	chr19	7963146	3'UTR	novel		0.3
BRCA	chr19	7959064	3'Flank	rs76513943		0.41
BRCA	chr19	7973788	Missense_Mutation	novel	E123Q	0.05
BRCA	chr19	7963472	3'UTR	novel		0.21
BRCA	chr19	7967577	Missense_Mutation	rs756868982	A215V	0.53
BRCA	chr19	7961977	3'Flank	novel		0.32
BRCA	chr19	7991785	Missense_Mutation	rs368659692	E11K	0.2
BRCA	chr19	7981132	Missense_Mutation	NA	R76T	0.31
BRCA	chr19	7962810	3'UTR	novel		0.27
BRCA	chr19	7991752	Missense_Mutation	NA	L22V	0.25
BRCA	chr19	7967597	Silent	NA	G208G	0.2
CESC	chr19	7962136	3'Flank	rs371024460		0.25
CESC	chr19	7991698	Missense_Mutation	novel	F40L	0.33	RRM_5
CESC	chr19	7963661	Missense_Mutation	NA	G268A	0.31
CESC	chr19	7991785	Nonsense_Mutation	NA	E11*	0.11
CESC	chr19	7962431	3'UTR	novel		0.38
CHOL	chr19	7991732	Silent	novel	P28P	0.4
COAD	chr19	7967600	Silent	rs377051094	F207F	0.37
COAD	chr19	7963802	Missense_Mutation	NA	S221F	0.27
COAD	chr19	7967645	Silent	rs772532543	N192N	0.15
COAD	chr19	7967639	Silent	novel	A194A	0.41
COAD	chr19	7973728	Missense_Mutation	NA	T143A	0.51
COAD	chr19	7981129	Frame_Shift_Ins	novel	*A77Efs6**	0.33
COAD	chr19	7963765	Silent	rs200745899	G233G	0.41
COAD	chr19	7963353	3'UTR	novel		0.21
COAD	chr19	7963747	Missense_Mutation	novel	N239K	0.3
COAD	chr19	8305247	Intron	novel		0.44
COAD	chr19	7981129	Missense_Mutation	NA	A77V	0.19
COAD	chr19	7991757	Missense_Mutation	NA	T20M	0.24
COAD	chr19	7963590	Missense_Mutation	NA	M292V	0.24
DLBC	chr19	7981180	Missense_Mutation	novel	S60N	0.3	RRM_5
DLBC	chr19	7981091	Missense_Mutation	novel	T90P	0.43
ESCA	chr19	7960427	3'Flank	novel		0.38
ESCA	chr19	7963579	Frame_Shift_Del	novel	Y295*	0.3
ESCA	chr19	7967758	Missense_Mutation	novel	D155H	0.46
ESCA	chr19	7963151	3'UTR	novel		0.25
ESCA	chr19	7963682	Missense_Mutation	novel	W261L	0.42
GBM	chr19	7967632	Missense_Mutation	novel	S197A	0.25
GBM	chr19	7973862	Frame_Shift_Ins	novel	*P98Lfs6**	0.12
GBM	chr19	7963435	3'UTR	novel		0.14
GBM	chr19	7963755	Missense_Mutation	NA	P237S	0.29
HNSC	chr19	7991771	Frame_Shift_Ins	novel	D16*	0.22
HNSC	chr19	7973874	Missense_Mutation	novel	S94L	0.17
HNSC	chr19	7967734	Missense_Mutation	novel	A163T	0.18
HNSC	chr19	7967752	Missense_Mutation	novel	R157W	0.42
HNSC	chr19	7963633	Silent	rs768748811	R277R	0.46
HNSC	chr19	7981091	Missense_Mutation	novel	T90P	0.22
HNSC	chr19	7981129	Missense_Mutation	NA	A77V	0.3
KIRP	chr19	7973864	Silent	NA	R97R	0.17
KIRP	chr19	8308357	Intron	novel		0.44
LAML	chr19	7967577	Missense_Mutation	rs756868982	A215V	0.24
LGG	chr19	7973774	Silent	rs549532291	S127S	0.16
LGG	chr19	7967690	Silent	novel	E177E	0.39
LIHC	chr19	7963681	Missense_Mutation	NA	W261C	0.57
LIHC	chr19	7973820	Missense_Mutation	NA	G112V	0.3
LIHC	chr19	7967718	Missense_Mutation	rs768294547	N168S	0.33
LUAD	chr19	7981129	Frame_Shift_Ins	novel	*A77Efs6**	0.22
LUAD	chr19	7973791	Missense_Mutation	NA	V122L	0.16
LUAD	chr19	7967758	Missense_Mutation	novel	D155H	0.2
LUAD	chr19	7991825	5'UTR	novel		0.13
LUSC	chr19	7981082	Splice_Site	NA	X92_splice	0.45
LUSC	chr19	7963746	Missense_Mutation	rs770736507	A240T	0.81
LUSC	chr19	7991811	Missense_Mutation	novel	S2C	0.6
LUSC	chr19	7973827	Missense_Mutation	novel	I110F	0.21
LUSC	chr19	7967752	Missense_Mutation	novel	R157W	0.73
OV	chr19	7973846	Silent	novel	I103I	0.07
OV	chr19	7973847	Missense_Mutation	novel	I103N	0.05
OV	chr19	7981132	Missense_Mutation	novel	R76K	0.07
OV	chr19	7981132	Missense_Mutation	NA	R76T	0.06
OV	chr19	7963627	Silent	novel	F279F	0.16
OV	chr19	7981103	Missense_Mutation	novel	L86F	0.15
PAAD	chr19	7981180	Missense_Mutation	novel	S60I	0.21	RRM_5
READ	chr19	7963507	Silent	NA	F319F	0.3
READ	chr19	7991789	Frame_Shift_Del	novel	*M9Sfs7**	0.28
READ	chr19	7981156	Missense_Mutation	novel	Y68C	0.22
SARC	chr19	7962613	3'UTR	novel		0.53
SKCM	chr19	8261971	Splice_Region	novel		0.19
SKCM	chr19	7963673	Missense_Mutation	novel	F264C	0.16
SKCM	chr19	7991760	Missense_Mutation	NA	R19K	0.22
SKCM	chr19	7963798	Splice_Site	novel	X219_splice	0.27
SKCM	chr19	7967592	Missense_Mutation	NA	P210L	0.44
STAD	chr19	7991764	Missense_Mutation	NA	G18R	0.26
STAD	chr19	7963464	3'UTR	rs760233337		0.33
STAD	chr19	7963464	3'UTR	rs760233337		0.46
STAD	chr19	7981147	Missense_Mutation	rs757692680	A71V	0.3
STAD	chr19	7963634	Missense_Mutation	NA	R277H	0.34
STAD	chr19	7963692	Missense_Mutation	novel	G258R	0.18
STAD	chr19	7967764	Missense_Mutation	NA	R153W	0.35
STAD	chr19	7963530	Frame_Shift_Del	novel	*D312Tfs27**	0.22
STAD	chr19	7963547	Missense_Mutation	NA	N306S	0.27
STAD	chr19	7991733	Missense_Mutation	NA	P28L	0.11	RRM_5
STAD	chr19	7973764	Missense_Mutation	NA	R131W	0.69
STAD	chr19	7991722	Missense_Mutation	NA	T32A	0.2	RRM_5
UCEC	chr19	7962303	3'UTR	novel		0.49
UCEC	chr19	7991659	Missense_Mutation	rs748009879	R53W	0.3	RRM_5
UCEC	chr19	7959180	3'Flank	novel		0.21
UCEC	chr19	7973778	Missense_Mutation	novel	F126S	0.07
UCEC	chr19	7981146	Silent	rs754355375	A71A	0.38
UCEC	chr19	7958929	3'Flank	novel		0.4
UCEC	chr19	7981180	Missense_Mutation	novel	S60I	0.27	RRM_5
UCEC	chr19	7962946	3'UTR	novel		0.31
UCEC	chr19	7981113	Silent	rs201603573	N82N	0.31
UCEC	chr19	7981134	Missense_Mutation	NA	E75D	0.43
UCEC	chr19	7967608	Nonsense_Mutation	NA	R205*	0.38
UCEC	chr19	7973814	Missense_Mutation	NA	P114L	0.49
UCEC	chr19	7981129	Missense_Mutation	NA	A77V	0.42
UCEC	chr19	7962525	3'UTR	novel		0.24
UCEC	chr19	7963464	3'UTR	rs760233337		0.53
UCEC	chr19	7962652	3'UTR	novel		0.41
UCEC	chr19	7973777	Missense_Mutation	novel	F126L	0.11
UCEC	chr19	7959059	3'Flank	novel		0.23
UCEC	chr19	7963397	3'UTR	novel		0.24
UCEC	chr19	7963789	Silent	novel	V225V	0.08
UCEC	chr19	7962327	3'UTR	novel		0.36
UCEC	chr19	7967586	Missense_Mutation	NA	H212R	0.38
UCEC	chr19	7959409	3'Flank	novel		0.25
UCEC	chr19	7958952	3'Flank	novel		0.42
UCEC	chr19	7967590	Missense_Mutation	rs750293457	V211I	0.3
UCEC	chr19	7963758	Missense_Mutation	novel	V236M	0.33
UCEC	chr19	7963464	3'UTR	rs760233337		0.33
UCEC	chr19	7991757	Missense_Mutation	NA	T20M	0.32
UCEC	chr19	7963253	3'UTR	novel		0.41
UCEC	chr19	7962142	3'Flank	novel		0.38
UCEC	chr19	7962398	3'UTR	novel		0.31
UCEC	chr19	7963567	Silent	rs780749922	A299A	0.52
UCEC	chr19	7963124	3'UTR	novel		0.5
UCEC	chr19	7963113	3'UTR	novel		0.46
UCEC	chr19	7962349	3'UTR	novel		0.31
UCEC	chr19	7963464	3'UTR	rs760233337		0.42
UCEC	chr19	7962275	3'UTR	novel		0.52
UCEC	chr19	7962240	3'Flank	novel		0.52
UCEC	chr19	7962877	3'UTR	novel		0.21
UCEC	chr19	7962122	3'Flank	novel		0.5
UCEC	chr19	7962256	3'Flank	novel		0.54
UCEC	chr19	7963538	Missense_Mutation	novel	R309H	0.27
UCEC	chr19	7963738	Silent	rs182490610	S242S	0.35
UCEC	chr19	7963788	Missense_Mutation	novel	D226N	0.29
UCEC	chr19	7960746	3'Flank	novel		0.63
UCEC	chr19	7963349	3'UTR	novel		0.16
UCEC	chr19	7963635	Missense_Mutation	novel	R277C	0.1
UCEC	chr19	7991818	5'UTR	novel		0.41
UCEC	chr19	7991820	5'UTR	novel		0.33
UCEC	chr19	7959058	3'Flank	novel		0.57
UCEC	chr19	7963464	3'UTR	rs760233337		0.53
UCEC	chr19	7981129	Missense_Mutation	NA	A77V	0.28
UCEC	chr19	7963464	3'UTR	rs760233337		0.39
UCEC	chr19	7967791	Splice_Site	NA	X144_splice	0.45
UCEC	chr19	7967608	Nonsense_Mutation	NA	R205*	0.42
UCEC	chr19	7959062	3'Flank	novel		0.32
UCEC	chr19	7963594	Silent	novel	V290V	0.2
UCEC	chr19	7981082	Splice_Site	NA	X92_splice	0.39
UCEC	chr19	7963798	Frame_Shift_Del	novel	*M223Wfs6**	0.35
UCEC	chr19	7973755	Missense_Mutation	novel	N134D	0.33
UCEC	chr19	7963667	Missense_Mutation	NA	P266L	0.55
UCEC	chr19	7962861	3'UTR	novel		0.36
UCEC	chr19	7981129	Missense_Mutation	NA	A77V	0.3
UCEC	chr19	7962564	3'UTR	novel		0.45
UCEC	chr19	7963327	3'UTR	novel		0.11

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0833	0.032222
READ	DEL	0.103	0.23023
THCA	DEL	0.014	0.10598

Survival Analysis

Cancer	P-value	Q-value
THYM	0.047	Kaplan-Meier Survival Analysis
SARC	0.022	Kaplan-Meier Survival Analysis
MESO	0.002	Kaplan-Meier Survival Analysis
ACC	0.00021	Kaplan-Meier Survival Analysis
HNSC	0.024	Kaplan-Meier Survival Analysis
PRAD	0.043	Kaplan-Meier Survival Analysis
KIRP	0.008	Kaplan-Meier Survival Analysis
BLCA	0.0041	Kaplan-Meier Survival Analysis
CESC	0.015	Kaplan-Meier Survival Analysis
KICH	0.027	Kaplan-Meier Survival Analysis
LIHC	0.0003	Kaplan-Meier Survival Analysis
LGG	0.0002	Kaplan-Meier Survival Analysis
THCA	0.0034	Kaplan-Meier Survival Analysis
LUAD	0.013	Kaplan-Meier Survival Analysis
OV	0.0066	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000066044 (Gene tree)
Gene ID: 1994
Gene Symbol: ELAVL1
Alias: HuR|Hua|MelG|HUR
Full Name: ELAV like RNA binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 47,087 bases
Position: chr19:7,958,573-8,005,659
Accession: 3312
RBP type: canonical RBP
Summary: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000385269	RRM_5	PF13893.6	1.4e-10	1	2
ENSP00000385269	RRM_5	PF13893.6	1.4e-10	2	2
ENSP00000472197	RRM_5	PF13893.6	1.4e-10	1	2
ENSP00000472197	RRM_5	PF13893.6	1.4e-10	2	2
ENSP00000385269	RRM_1	PF00076.22	2.5e-61	1	3
ENSP00000385269	RRM_1	PF00076.22	2.5e-61	2	3
ENSP00000385269	RRM_1	PF00076.22	2.5e-61	3	3
ENSP00000472197	RRM_1	PF00076.22	2.5e-61	1	3
ENSP00000472197	RRM_1	PF00076.22	2.5e-61	2	3
ENSP00000472197	RRM_1	PF00076.22	2.5e-61	3	3
ENSP00000470727	RRM_1	PF00076.22	7.8e-29	1	2
ENSP00000470727	RRM_1	PF00076.22	7.8e-29	2	2
ENSP00000471011	RRM_1	PF00076.22	1.2e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27198227	HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP.	Genes Dev	2016 May 15	Noh JH	doi: 10.1101/gad.276022.115
28882869	Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration.	Arterioscler Thromb Vasc Biol	2018 Jan	Nguyen MA	doi: 10.1161/ATVBAHA.117.309795
22511768	Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage-inhibitory cytokine 1.	J Biol Chem	2012 Jun 8	Park SH	doi: 10.1074/jbc.M111.330639
29637882	Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi.	Am J Trop Med Hyg	2018 Jun	Feintuch CM	doi: 10.4269/ajtmh.17-0887
30787392	Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA.	Cell Death Differ	2019 Feb 20	Wang M	doi: 10.1038/s41418-019-0304-y
23901138	miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR.	Sci Signal	2013 Jul 30	Balkhi MY	doi: 10.1126/scisignal.2004177.
20102719	HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.	Gastroenterology	2010 May	Vazquez-Chantada M	doi: 10.1053/j.gastro.2010.01.032
19255485	Cloning, expression, purification and preliminary crystallographic studies of the adenylate/uridylate-rich element-binding protein HuR complexed with its target RNA.	Acta Crystallogr Sect F Struct Biol Cryst Commun	2009 Mar 1	Iyaguchi D	doi: 10.1107/S174430910900400X
14715706	Interaction between 3' untranslated region of calcitonin receptor messenger ribonucleic acid (RNA) and adenylate/uridylate (AU)-rich element binding proteins (AU-rich RNA-binding factor 1 and Hu antigen R).	Endocrinology	2004 Apr	Yasuda S	-
19591856	HuR/ELAVL1 RNA binding protein modulates interleukin-8 induction by muco-active ribotoxin deoxynivalenol.	Toxicol Appl Pharmacol	2009 Oct 1	Choi HJ	doi: 10.1016/j.taap.2009.06.023
19246637	Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R.	Am J Pathol	2009 Apr	Doller A	doi: 10.2353/ajpath.2009.080652
22371495	The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation.	J Biol Chem	2012 Apr 27	Cho SJ	doi: 10.1074/jbc.M111.326827
20453031	Aldosterone and vasopressin affect {alpha}- and {gamma}-ENaC mRNA translation.	Nucleic Acids Res	2010 Sep	Perlewitz A	doi: 10.1093/nar/gkq267
25584704	The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets.	RNA Biol	2014	Scheiba RM	doi: 10.1080/15476286.2014.996069.
23519412	The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding.	Acta Crystallogr D Biol Crystallogr	2013 Mar	Wang H	doi: 10.1107/S0907444912047828
28333956	Discriminating between HuR and TTP binding sites using the k-spectrum kernel method.	PLoS One	2017 Mar 23	Bhandare S	doi: 10.1371/journal.pone.0174052
26512911	Identification of novel proteins binding the AU-rich element of -and-alpha;-prothymosin mRNA through the selection of open reading frames (RIDome).	RNA Biol	2015	Patrucco L	doi: 10.1080/15476286.2015.1107702.
27738870	Differentially Expressed Long Non-Coding RNAs Were Predicted to Be Involved in the Control of Signaling Pathways in Pediatric Astrocytoma.	Mol Neurobiol	2017 Oct	Ruiz Esparza-Garrido R	doi: 10.1007/s12035-016-0123-9
28934484	Regulation of HuR structure and function by dihydrotanshinone-I.	Nucleic Acids Res	2017 Sep 19	Lal P	doi: 10.1093/nar/gkx623.
29285201	Effects of HuR downregulation on anaplastic thyroid cancer cells.	Oncol Lett	2018 Jan	Allegri L	doi: 10.3892/ol.2017.7289
29361849	Role of Complex Epigenetic Switching in Tumor Necrosis Factor--and-alpha; Upregulation in the Prefrontal Cortex of Suicide Subjects.	Am J Psychiatry	2018 Mar 1	Wang Q	doi: 10.1176/appi.ajp.2017.16070759
29678826	RNA Binding Protein, HuR, Regulates SCN5A Expression Through Stabilizing MEF2C transcription factor mRNA.	J Am Heart Assoc	2018 Apr 20	Zhou A	doi: 10.1161/JAHA.117.007802.
29719611	Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells.	Oncotarget	2018 Apr 6	Badawi A	doi: 10.18632/oncotarget.24840
29724820	Temporal and Spatial Post-Transcriptional Regulation of Zebrafish tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly.	Arterioscler Thromb Vasc Biol	2018 Jul	Chowdhury TA	doi: 10.1161/ATVBAHA.118.310848
30182452	LncRNA B4GALT1-AS1 recruits HuR to promote osteosarcoma cells stemness and migration via enhancing YAP transcriptional activity.	Cell Prolif	2018 Dec	Li Z	doi: 10.1111/cpr.12504
30962286	AU-rich element-mediated mRNA decay via the butyrate response factor 1 controls cellular levels of polyadenylated replication-dependent histone mRNAs.	J Biol Chem	2019 May 10	Ryu I	doi: 10.1074/jbc.AC118.006766
30981768	Long non-coding RNA FENDRR attenuates the stemness of non-small cell lung cancer cells via decreasing multidrug resistance gene 1 (MDR1) expression through competitively binding with RNA binding protein HuR.	Eur J Pharmacol	2019 Jun 15	Gong F	doi: 10.1016/j.ejphar.2019.04.022
31103627	RNA-Binding Protein HuR Regulates Paneth Cell Function by Altering Membrane Localization of TLR2 via Post-transcriptional Control of CNPY3.	Gastroenterology	2019 May 17	Xiao L	doi: 10.1053/j.gastro.2019.05.010
24866260	Novel 1:1 labeling and purification process for C-terminal thioester and single cysteine recombinant proteins using generic peptidic toolbox reagents.	Bioconjug Chem	2014 Jul 16	Portal CF	doi: 10.1021/bc5000059
24687854	Transcript stabilization by the RNA-binding protein HuR is regulated by cellular retinoic acid-binding protein 2.	Mol Cell Biol	2014 Jun	Vreeland AC	doi: 10.1128/MCB.00281-14
9628880	Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs.	EMBO J	1998 Jun 15	Fan XC	-
12242302	Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization.	Mol Cell Biol	2002 Oct	Chen CY	-
16484227	Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element.	J Biol Chem	2006 Apr 21	Prechtel AT	-
16782553	The role of cytokine mRNA stability in the pathogenesis of autoimmune disease.	Autoimmun Rev	2006 May	Seko Y	-
14662769	Identification of RNA-binding proteins in RAW 264.7 cells that recognize a lipopolysaccharide-responsive element in the 3-untranslated region of the murine cyclooxygenase-2 mRNA.	J Biol Chem	2004 Feb 27	Cok SJ	-
18490444	MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90.	Mol Cell Biol	2008 Jul	Kuwano Y	doi: 10.1128/MCB.00165-08
22322302	Macrophage -and-beta;2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis.	Am J Pathol	2012 Apr	Zhang J	doi: 10.1016/j.ajpath.2011.12.025
22086907	Association of the von Hippel-Lindau protein with AUF1 and posttranscriptional regulation of VEGFA mRNA.	Mol Cancer Res	2012 Jan	Xin H	doi: 10.1158/1541-7786.MCR-11-0435
21209379	ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes.	Blood	2011 Feb 24	Mazan-Mamczarz K	doi: 10.1182/blood-2010-09-310987
20353946	Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR).	J Biol Chem	2010 May 28	von Roretz C	doi: 10.1074/jbc.M109.087320
20219472	The x-ray crystal structure of the first RNA recognition motif and site-directed mutagenesis suggest a possible HuR redox sensing mechanism.	J Mol Biol	2010 Apr 16	Benoit RM	doi: 10.1016/j.jmb.2010.02.043
25534855	HuR represses Wnt/-and-beta;-catenin-mediated transcriptional activity by promoting cytoplasmic localization of -and-beta;-catenin.	Biochem Biophys Res Commun	2015 Jan 30	Kim I	doi: 10.1016/j.bbrc.2014.12.052
25239623	Hu antigen R (HuR) is a positive regulator of the RNA-binding proteins TDP-43 and FUS/TLS: implications for amyotrophic lateral sclerosis.	J Biol Chem	2014 Nov 14	Lu L	doi: 10.1074/jbc.M114.573246
23864387	Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent.	Carcinogenesis	2013 Dec	Chu PC	doi: 10.1093/carcin/bgt251
27197265	The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial-Mesenchymal Transition in Breast Cancer.	Cancer Res	2016 May 1	Latorre E	doi: 10.1158/0008-5472.CAN-15-2018
26884465	H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR.	Mol Cell Biol	2016 Apr 15	Zou T	doi: 10.1128/MCB.01030-15
26021887	Lipoteichoic acid isolated from Lactobacillus plantarum inhibits melanogenesis in B16F10 mouse melanoma cells.	Mol Cells	2015	Kim HR	doi: 10.14348/molcells.2015.2263
25980610	Lymphotoxin -and-alpha;, a novel target of posttranscriptional gene regulation by HuR in HepG2 cells.	FEBS Lett	2015 Jul 8	Steinmeyer N	doi: 10.1016/j.febslet.2015.05.015
28553126	RNA-binding protein HuR promotes bladder cancer progression by competitively binding to the long noncoding HOTAIR with miR-1.	Onco Targets Ther	2017 May 17	Yu D	doi: 10.2147/OTT.S132728
29492508	RNA-binding protein HuR regulates hsa-let-7c expression by its RNA recognition motif.	Sheng Li Xue Bao	2018 Feb 25	Song Y	-
30418581	HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs.	Nucleic Acids Res	2019 Jan 25	Pabis M	doi: 10.1093/nar/gky1138.
12431987	The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein.	J Biol Chem	2003 Jan 31	Giles KM	-
11280780	HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3' untranslated regions of cytokine and angiogenic factor mRNAs.	Cancer Res	2001 Mar 1	Nabors LB	-
10737787	HuR binding to cytoplasmic mRNA is perturbed by heat shock.	Proc Natl Acad Sci U S A	2000 Mar 28	Gallouzi IE	-
16170373	Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma.	Oncogene	2005 Nov 24	Datta K	-
15525674	Staufen recruitment into stress granules does not affect early mRNA transport in oligodendrocytes.	Mol Biol Cell	2005 Jan	Thomas MG	-
15371446	Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR.	J Biol Chem	2004 Nov 19	Yang X	-
14517280	Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells.	Mol Cell Biol	2003 Oct	Galban S	-
20086103	Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR.	Mol Cell Biol	2010 Mar	Doller A	doi: 10.1128/MCB.01373-09
19728080	The RNA-binding protein HuR regulates GATA3 mRNA stability in human breast cancer cell lines.	Breast Cancer Res Treat	2010 Jul	Licata LA	doi: 10.1007/s10549-009-0517-8
22921787	Cancer cell growth suppression by a 62nt AU-rich RNA from C/EBP-and-beta; 3'UTR through competitive binding with HuR.	Biochem Biophys Res Commun	2012 Sep 14	Sun DQ	doi: 10.1016/j.bbrc.2012.08.049
23394580	MiR-200c and HuR in ovarian cancer.	BMC Cancer	2013 Feb 8	Prislei S	doi: 10.1186/1471-2407-13-72.
22426177	HuR post-transcriptionally regulates TNF--and-alpha;-induced IL-6 expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin.	Respir Physiol Neurobiol	2012 Apr 30	Shi JX	doi: 10.1016/j.resp.2012.02.011
22414048	Anti-inflammatory effects of methoxyphenolic compounds on human airway cells.	J Inflamm (Lond)	2012 Mar 13	Houser KR	doi: 10.1186/1476-9255-9-6.
21917750	AU-rich RNA binding proteins in hematopoiesis and leukemogenesis.	Blood	2011 Nov 24	Baou M	doi: 10.1182/blood-2011-07-347237
21890634	Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites.	J Biol Chem	2011 Oct 28	Uren PJ	doi: 10.1074/jbc.C111.266882
21233170	Different modes of interaction by TIAR and HuR with target RNA and DNA.	Nucleic Acids Res	2011 Feb	Kim HS	doi: 10.1093/nar/gkq837
21233286	Novel mRNA-containing cytoplasmic granules in ALK-transformed cells.	Mol Biol Cell	2011 Mar 15	Fawal M	doi: 10.1091/mbc.E10-07-0569
23226427	Cyclooxygenase-2 is a target of microRNA-16 in human hepatoma cells.	PLoS One	2012	Agra Andrieu N	doi: 10.1371/journal.pone.0050935
20587520	HuR regulates beta-tubulin isotype expression in ovarian cancer.	Cancer Res	2010 Jul 15	Raspaglio G	doi: 10.1158/0008-5472.CAN-09-4656
20519371	The poly(c)-binding protein-1 regulates expression of the androgen receptor.	Endocrinology	2010 Aug	Cloke B	doi: 10.1210//en.2009-1264
23155001	Competitive binding of CUGBP1 and HuR to occludin mRNA controls its translation and modulates epithelial barrier function.	Mol Biol Cell	2013 Jan	Yu TX	doi: 10.1091/mbc.E12-07-0531
24740539	Jnk2 deletion disrupts intestinal mucosal homeostasis and maturation by differentially modulating RNA-binding proteins HuR and CUGBP1.	Am J Physiol Cell Physiol	2014 Jun 15	Chung HK	doi: 10.1152/ajpcell.00093.2014
24621334	Reduction of TLR4 mRNA stability and protein expressions through inhibiting cytoplasmic translocation of HuR transcription factor by E and/or ER-and-alpha; in LPS-treated H9c2 cardiomyoblast cells.	Chin J Physiol	2014 Feb 28	Fan MJ	doi: 10.4077/CJP.2014.BAC197.
24166976	Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis.	J Immunol	2013 Dec 1	Chen J	doi: 10.4049/jimmunol.1301188
23861541	CCAAT/enhancer binding protein delta in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma.	Sci Signal	2013 Jul 16	Hsiao YW	doi: 10.1126/scisignal.2003648.
23776146	Specificity factors in cytoplasmic polyadenylation.	Wiley Interdiscip Rev RNA	2013 Jul-Aug	Charlesworth A	doi: 10.1002/wrna.1171.
26554012	A 3' untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR.	Proc Natl Acad Sci U S A	2015 Nov 24	Suhl JA	doi: 10.1073/pnas.1514260112
26677051	Human Antigen R Binding and Regulation of SOX2 mRNA in Human Mesenchymal Stem Cells.	Mol Pharmacol	2016 Feb	Latorre E	doi: 10.1124/mol.115.100701
26491048	CUGBP1 and HuR regulate E-cadherin translation by altering recruitment of E-cadherin mRNA to processing bodies and modulate epithelial barrier function.	Am J Physiol Cell Physiol	2016 Jan 1	Yu TX	doi: 10.1152/ajpcell.00112.2015
26177105	Cooperative interplay of let-7 mimic and HuR with MYC RNA.	Cell Cycle	2015	Gunzburg MJ	doi: 10.1080/15384101.2015.1069930
25867965	HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGF-and-beta;-signaling in hypoxic microenvironment.	Sci Rep	2015 Apr 13	Nagpal N	doi: 10.1038/srep09650.
28684423	The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.	J Biol Chem	2017 Sep 1	Chen J	doi: 10.1074/jbc.M117.782771
27742911	Quantifying RNA binding sites transcriptome-wide using DO-RIP-seq.	RNA	2017 Jan	Nicholson CO	-
29222492	Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression.	Sci Rep	2017 Dec 8	Chen J	doi: 10.1038/s41598-017-17371-5.
29413897	The AU-rich element landscape across human transcriptome reveals a large proportion in introns and regulation by ELAVL1/HuR.	Biochim Biophys Acta Gene Regul Mech	2018 Feb	Bakheet T	doi: 10.1016/j.bbagrm.2017.12.006
29931370	Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.	Nucleic Acids Res	2018 Jun 20	Lan Y	doi: 10.1093/nar/gky214.
31188427	The RNA-binding Protein ELAVL1 Regulates GnRH Receptor Expression and the Response to GnRH.	Endocrinology	2019 Jun 12	Terasaka T	doi: 10.1210/en.2019-00203
9628881	RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein.	EMBO J	1998 Jun 15	Peng SS	-
9003489	Localization of the human HuR gene to chromosome 19p13.2.	Hum Genet	1997 Jan	Ma WJ	-
16569663	NMDA induces post-transcriptional regulation of alpha2-guanylyl-cyclase-subunit expression in cerebellar granule cells.	J Cell Sci	2006 Apr 15	Jurado S	-
16581801	Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR.	Mol Cell Biol	2006 Apr	Kawai T	-
12944397	RNAi-mediated HuR depletion leads to the inhibition of muscle cell differentiation.	J Biol Chem	2003 Nov 21	van der Giessen K	-
12821781	RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.	Proc Natl Acad Sci U S A	2003 Jul 8	Mazan-Mamczarz K	-
12605686	The 3'-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR.	Eur J Biochem	2003 Jan	Wein G	-
12384588	Expression of the human RNA-binding protein HuR in Trypanosoma brucei increases the abundance of mRNAs containing AU-rich regulatory elements.	Nucleic Acids Res	2002 Oct 15	Quijada L	-
12237300	Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase.	J Biol Chem	2002 Nov 22	Li H	-
12196519	Nutritional control of mRNA stability is mediated by a conserved AU-rich element that binds the cytoplasmic shuttling protein HuR.	J Biol Chem	2002 Nov 1	Yaman I	-
16494882	LPL-mediated lipolysis of VLDL induces an upregulation of AU-rich mRNAs and an activation of HuR in endothelial cells.	Atherosclerosis	2006 Dec	Tschernatsch MM	-
12011088	Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA.	J Biol Chem	2002 Jul 26	Yeap BB	-
11741601	HuR binds a cyclic nucleotide-dependent, stabilizing domain in the 3' untranslated region of Na(+)/glucose cotransporter (SGLT1) mRNA.	FEBS Lett	2001 Dec 7	Loflin P	-
11602610	HuA and tristetraprolin are induced following T cell activation and display distinct but overlapping RNA binding specificities.	J Biol Chem	2001 Dec 21	Raghavan A	-
11565755	Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock.	RNA	2001 Sep	Gallouzi IE	-
11356683	Androgen regulates the level and subcellular distribution of the AU-rich ribonucleic acid-binding protein HuR both in vitro and in vivo.	Endocrinology	2001 Jun	Sheflin LG	-
11289308	HuR and mRNA stability.	Cell Mol Life Sci	2001 Feb	Brennan CM	-
11018049	Protein ligands to HuR modulate its interaction with target mRNAs in vivo.	J Cell Biol	2000 Oct 2	Brennan CM	-
10859327	Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR.	J Biol Chem	2000 Aug 25	Rodriguez-Pascual F	-
10660597	Purification and characterization of beta-adrenergic receptor mRNA-binding proteins.	J Biol Chem	2000 Feb 11	Blaxall BC	-
10629032	HuR regulates p21 mRNA stabilization by UV light.	Mol Cell Biol	2000 Feb	Wang W	-
16890199	Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR.	Biochem Biophys Res Commun	2006 Sep 22	Izquierdo JM	-
16242680	Role of ELAV-like RNA-binding proteins HuD and HuR in the post-transcriptional regulation of acetylcholinesterase in neurons and skeletal muscle cells.	Chem Biol Interact	2005 Dec 15	Deschenes-Furry J	-
16221671	Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.	J Biol Chem	2005 Dec 30	Baez MV	-
16168373	HuR as a negative posttranscriptional modulator in inflammation.	Mol Cell	2005 Sep 16	Katsanou V	-
16135804	RNA-binding protein HuR is required for stabilization of SLC11A1 mRNA and SLC11A1 protein expression.	Mol Cell Biol	2005 Sep	Xu YZ	-
16109718	Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization.	J Biol Chem	2005 Oct 14	Pan YX	-
15878846	The RNA-binding protein HuR binds to acetylcholinesterase transcripts and regulates their expression in differentiating skeletal muscle cells.	J Biol Chem	2005 Jul 8	Deschenes-Furry J	-
15861128	Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha.	EMBO J	2005 May 18	Lal A	-
16831604	S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase.	Gastroenterology	2006 Jul	Martinez-Chantar ML	-
15543229	RhoB mRNA is stabilized by HuR after UV light.	Oncogene	2005 Jan 13	Westmark CJ	-
15514971	IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR.	Int J Cancer	2005 Mar 1	Suswam EA	-
16801526	HuD distribution changes in response to heat shock but not neurotrophic stimulation.	J Histochem Cytochem	2006 Oct	Burry RW	-
15257295	Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs.	EMBO J	2004 Aug 4	Lal A	-
14981248	Transportin2 functions as importin and mediates nuclear import of HuR.	Proc Natl Acad Sci U S A	2004 Mar 2	Guttinger S	-
14523003	ATP potentiates interleukin-1 beta-induced MMP-9 expression in mesangial cells via recruitment of the ELAV protein HuR.	J Biol Chem	2003 Dec 19	Huwiler A	-
14530362	Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR.	J Immunol	2003 Oct 15	Atasoy U	-
23127556	HuR posttranscriptionally regulates early growth response-1 (Egr-1) expression at the early stage of T cell activation.	FEBS Lett	2012 Dec 14	Mou Z	doi: 10.1016/j.febslet.2012.10.040
20064878	RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability.	Nucleic Acids Res	2010 Apr	Cho SJ	doi: 10.1093/nar/gkp1229
20001965	Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis.	Biochem J	2010 Feb 24	Wang PY	doi: 10.1042/BJ20091459.
20007147	Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence.	Nucleic Acids Res	2010 Mar	Yi J	doi: 10.1093/nar/gkp1114
20018854	Transcriptional control of human antigen R by bone morphogenetic protein.	J Biol Chem	2010 Feb 12	Jeyaraj SC	doi: 10.1074/jbc.M109.062216
19875930	MicroRNA-125a represses cell growth by targeting HuR in breast cancer.	RNA Biol	2009 Nov-Dec	Guo X	-
19884656	Essential role of the RNA-binding protein HuR in progenitor cell survival in mice.	J Clin Invest	2009 Dec	Ghosh M	doi: 10.1172/JCI38263
19812253	Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation.	Mol Biol Cell	2009 Dec	Liu L	doi: 10.1091/mbc.E09-07-0550
19825980	Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines.	Nucleic Acids Res	2009 Dec	Zhang X	doi: 10.1093/nar/gkp755.
19487279	The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase.	Cancer Res	2009 Jun 1	Costantino CL	doi: 10.1158/0008-5472.CAN-09-0371.
19359363	Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation.	Nucleic Acids Res	2009 Jun	Al-Ahmadi W	doi: 10.1093/nar/gkp223
19322201	Ubiquitin-mediated proteolysis of HuR by heat shock.	EMBO J	2009 May 6	Abdelmohsen K	doi: 10.1038/emboj.2009.67
19327732	HuR and TTP: two RNA binding proteins that deliver message from the 3' end.	Gastroenterology	2009 May	Anant S	doi: 10.1053/j.gastro.2009.03.024
19307312	The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development.	Mol Cell Biol	2009 May	Katsanou V	doi: 10.1128/MCB.01393-08
19252527	RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth.	Oncogene	2009 Apr 16	Al-Ahmadi W	doi: 10.1038/onc.2009.16
19270063	The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA.	Nucleic Acids Res	2009 May	Lopez de Silanes I	doi: 10.1093/nar/gkp123
23028944	HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via deltaNp63.	PLoS One	2012	Yan W	doi: 10.1371/journal.pone.0045336
19208339	The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis.	Gastroenterology	2009 May	Young LE	doi: 10.1053/j.gastro.2009.01.010
19151756	Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer.	Oncogene	2009 Mar 5	Woo HH	doi: 10.1038/onc.2008.469
19130553	Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression.	Eur J Immunol	2009 Jan	Chemnitz J	doi: 10.1002/eji.200838619.
19088191	miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels.	Proc Natl Acad Sci U S A	2008 Dec 23	Abdelmohsen K	doi: 10.1073/pnas.0809376106
19106619	Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2.	RNA Biol	2009 Jan-Mar	Bubenik JL	-
19056930	von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR.	Carcinogenesis	2009 Mar	Danilin S	doi: 10.1093/carcin/bgn275
18991684	Post-transcriptional regulation of HSP70 expression following oxidative stress in SH-SY5Y cells: the potential involvement of the RNA-binding protein HuR.	Curr Pharm Des	2008	Amadio M	-
19010922	Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR.	Cancer Res	2008 Nov 15	Saunus JM	doi: 10.1158/0008-5472.CAN-08-1159.
19014379	Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.	J Neurochem	2008 Dec	Tiruchinapalli DM	doi: 10.1111/j.1471-4159.2008.05718.x
18927508	Phosphorylated HuR shuttles in cycles.	Cell Cycle	2008 Oct	Kim HH	-
18769129	Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells.	Cancer Biol Ther	2008 Sep	Hostetter C	-
18687667	HuR and the bioenergetic signature of breast cancer: a low tumor expression of the RNA-binding protein predicts a higher risk of disease recurrence.	Carcinogenesis	2008 Nov	Ortega AD	doi: 10.1093/carcin/bgn185
18579691	RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment.	Mol Biol Cell	2008 Sep	Yeh CH	doi: 10.1091/mbc.E07-09-0962
18593881	Nuclear HuR accumulation through phosphorylation by Cdk1.	Genes Dev	2008 Jul 1	Kim HH	doi: 10.1101/gad.1645808.
22955946	Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis.	Cell Death Differ	2013 Jan	von Roretz C	doi: 10.1038/cdd.2012.111
18414021	Interplay between microRNAs and RNA-binding proteins determines developmental processes.	Cell Cycle	2008 Apr 1	Kedde M	-
18405437	Bovine oocytes and early embryos express Staufen and ELAVL RNA-binding proteins.	Zygote	2008 May	Calder MD	doi: 10.1017/S096719940700456X.
18348177	Characterization of RNA-binding proteins possibly involved in modulating human AT 1 receptor mRNA stability.	Cell Biochem Funct	2008 Jun	Pende A	doi: 10.1002/cbf.1472.
18273060	Regulation of stress granule dynamics by Grb7 and FAK signalling pathway.	EMBO J	2008 Mar 5	Tsai NP	doi: 10.1038/emboj.2008.19
22915590	Dephosphorylation of HuR protein during alphavirus infection is associated with HuR relocalization to the cytoplasm.	J Biol Chem	2012 Oct 19	Dickson AM	doi: 10.1074/jbc.M112.371203
18245466	Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells.	Cancer Res	2008 Feb 1	Suswam E	doi: 10.1158/0008-5472.CAN-07-2751.
18215521	AsSIRTing the DNA damage response.	Trends Cell Biol	2008 Feb	Gorospe M	doi: 10.1016/j.tcb.2007.11.007
18161049	Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes.	Hepatology	2008 Feb	Matsui K	-
18180367	Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis.	J Cell Biol	2008 Jan 14	Mazroui R	doi: 10.1083/jcb.200709030
17967866	RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha.	Mol Cell Biol	2008 Jan	Galban S	-
22907529	Genetic polymorphisms in RNA binding proteins contribute to breast cancer survival.	Int J Cancer	2013 Feb 1	Upadhyay R	doi: 10.1002/ijc.27789
17914349	Renal response to metabolic acidosis: role of mRNA stabilization.	Kidney Int	2008 Jan	Ibrahim H	-
17804813	Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells.	Mol Biol Cell	2007 Nov	Xiao L	-
22841487	LincRNA-p21 suppresses target mRNA translation.	Mol Cell	2012 Aug 24	Yoon JH	doi: 10.1016/j.molcel.2012.06.027
17531241	HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR.	Atherosclerosis	2007 Nov	Zhou H	-
17534146	Posttranscriptional orchestration of an anti-apoptotic program by HuR.	Cell Cycle	2007 Jun 1	Abdelmohsen K	-
17517897	Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences.	J Biol Chem	2007 Jul 20	Fialcowitz-White EJ	-
17466948	The RNA-binding protein PTB exerts translational control on 3'-untranslated region of the mRNA for the ATP synthase beta-subunit.	Biochem Biophys Res Commun	2007 Jun 15	Reyes R	-
17475777	Involvement of transportin 2-mediated HuR import in muscle cell differentiation.	Mol Biol Cell	2007 Jul	van der Giessen K	-
17317621	HuR-SIRT: the hairy world of posttranscriptional control.	Mol Cell	2007 Feb 23	Wilusz CJ	-
17317627	Phosphorylation of HuR by Chk2 regulates SIRT1 expression.	Mol Cell	2007 Feb 23	Abdelmohsen K	-
22829587	Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function.	J Biol Chem	2012 Sep 14	Filippova N	doi: 10.1074/jbc.M112.353912
17074806	Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.	Mol Cell Biol	2007 Jan	Tong X	-
16990552	The role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation.	Arterioscler Thromb Vasc Biol	2006 Dec	Lin FY	-
23376935	Hyper conserved elements in vertebrate mRNA 3'-UTRs reveal a translational network of RNA-binding proteins controlled by HuR.	Nucleic Acids Res	2013 Mar 1	Dassi E	doi: 10.1093/nar/gkt017
22785201	HuR's post-transcriptional regulation of Death Receptor 5 in pancreatic cancer cells.	Cancer Biol Ther	2012 Aug	Pineda DM	doi: 10.4161/cbt.20952
22706953	HuR thermal stability is dependent on domain binding and upon phosphorylation.	Eur Biophys J	2012 Jul	Scheiba RM	doi: 10.1007/s00249-012-0827-3
22684254	The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r.	Nat Cell Biol	2012 Jun 10	Keniry A	doi: 10.1038/ncb2521.
22436134	Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells.	Mol Cancer	2012 Mar 21	Latorre E	doi: 10.1186/1476-4598-11-13.
22368252	Sequence requirements for RNA binding by HuR and AUF1.	J Biochem	2012 Apr	Barker A	doi: 10.1093/jb/mvs010
22258704	The oncogenic RNA-binding protein Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells.	Mol Cancer Res	2012 Jan	Vo DT	doi: 10.1158/1541-7786.MCR-11-0208.
22201685	Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis.	J Clin Invest	2012 Jan	Yiakouvaki A	doi: 10.1172/JCI45021
22212710	PDGF-induced airway smooth muscle proliferation is associated with Human antigen R activation and could be weakened by AMPK activation.	Mol Biol Rep	2012 May	Zhang P	doi: 10.1007/s11033-011-1392-z
22215620	Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR.	Mol Cell Biol	2012 Mar	Gabai VL	doi: 10.1128/MCB.05921-11
22139917	Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation.	Nucleic Acids Res	2012 Mar	Mansfield KD	doi: 10.1093/nar/gkr1114
22095636	Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.	Hepatology	2012 Apr	Embade N	doi: 10.1002/hep.24795
22049153	The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.	Mol Cancer Res	2012 Jan	Young LE	doi: 10.1158/1541-7786.MCR-11-0337
21971048	The RNA-binding protein HuR opposes the repression of ERBB-2 gene expression by microRNA miR-331-3p in prostate cancer cells.	J Biol Chem	2011 Dec 2	Epis MR	doi: 10.1074/jbc.M111.301481
21982546	RNA-binding proteins and gene regulation in myogenesis.	Trends Pharmacol Sci	2011 Nov	Apponi LH	doi: 10.1016/j.tips.2011.06.004
21935689	mRNA stability alterations mediated by HuR are necessary to sustain the fast growth of glioma cells.	J Neurooncol	2012 Feb	Bolognani F	doi: 10.1007/s11060-011-0707-1
21862584	The RNA-binding protein HuR stabilizes cytosolic phospholipase A2-and-alpha; mRNA under interleukin-1-and-beta; treatment in non-small cell lung cancer A549 Cells.	J Biol Chem	2011 Oct 14	Liao WL	doi: 10.1074/jbc.M111.263582
23269677	Post-transcriptional regulation of meprin -and-alpha; by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP).	J Biol Chem	2013 Feb 15	Roff AN	doi: 10.1074/jbc.M112.444208
21795698	Caspase-mediated cleavage of RNA-binding protein HuR regulates c-Myc protein expression after hypoxic stress.	J Biol Chem	2011 Sep 16	Talwar S	doi: 10.1074/jbc.M111.255927
21804532	3'UTR elements inhibit Ras-induced C/EBP-and-beta; post-translational activation and senescence in tumour cells.	EMBO J	2011 Jul 29	Basu SK	doi: 10.1038/emboj.2011.250.
21745814	Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function.	Nucleic Acids Res	2011 Oct	Yu TX	doi: 10.1093/nar/gkr567
21755477	Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression.	Adv Exp Med Biol	2011	Meisner NC	doi: 10.1007/978-1-4419-7823-3_10.
21768308	Translational control of TOP2A influences doxorubicin efficacy.	Mol Cell Biol	2011 Sep	Srikantan S	doi: 10.1128/MCB.05639-11
21723171	Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR.	Mol Cell	2011 Aug 5	Lebedeva S	doi: 10.1016/j.molcel.2011.06.008
21723170	Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.	Mol Cell	2011 Aug 5	Mukherjee N	doi: 10.1016/j.molcel.2011.06.007
21737689	The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages.	Mol Biol Cell	2011 Aug 15	Chi MN	doi: 10.1091/mbc.E11-03-0212
21688267	Post-transcriptional regulation of the Ras-ERK/MAPK signaling pathway.	J Cell Physiol	2012 Mar	Whelan JT	doi: 10.1002/jcp.22899.
21646354	Transportin 2 regulates apoptosis through the RNA-binding protein HuR.	J Biol Chem	2011 Jul 22	von Roretz C	doi: 10.1074/jbc.M110.216184
21613615	Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR.	J Immunol	2011 Jul 1	Stellato C	doi: 10.4049/jimmunol.1001881
21627034	Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression.	Adv Exp Med Biol	2010	Meisner NC	-
21498545	The RNA-binding protein HuR promotes glioma growth and treatment resistance.	Mol Cancer Res	2011 May	Filippova N	doi: 10.1158/1541-7786.MCR-10-0325
21443519	The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cells.	Biochem J	2011 Jul 1	Donahue JM	doi: 10.1042/BJ20110028.
21391979	Regulation of cyclooxygenase-2 and cytosolic phospholipase A2 gene expression by lipopolysaccharide through the RNA-binding protein HuR: involvement of NADPH oxidase, reactive oxygen species and mitogen-activated protein kinases.	Br J Pharmacol	2011 Aug	Lin WN	doi: 10.1111/j.1476-5381.2011.01312.x.
21402775	Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation.	Mol Cell Biol	2011 May	Nakamura H	doi: 10.1128/MCB.01424-10
21369731	The 3'-untranslated region length and AU-rich RNA location modulate RNA-protein interaction and translational control of -and-beta;2-adrenergic receptor mRNA.	Mol Cell Biochem	2011 Jun	Subramaniam K	doi: 10.1007/s11010-011-0747-z
21310943	High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells.	Carcinogenesis	2011 May	Doller A	doi: 10.1093/carcin/bgr024
21317874	Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation.	EMBO J	2011 Mar 16	Masuda K	doi: 10.1038/emboj.2011.24
23223443	Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.	J Biol Chem	2013 Feb 15	Chang SH	doi: 10.1074/jbc.M112.423871
21102524	RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation.	Oncogene	2011 Mar 24	Durie D	doi: 10.1038/onc.2010.527
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21046284	Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer.	Med Oncol	2011 Dec	Wang J	doi: 10.1007/s12032-010-9734-6
20889954	The mRNA-binding protein HuR is regulated in the menstrual cycle and repressed in ectopic endometrium.	Reprod Sci	2011 Feb	Karipcin FS	doi: 10.1177/1933719110382307
20881234	RNA-binding protein HuR regulates RGS4 mRNA stability in rabbit colonic smooth muscle cells.	Am J Physiol Cell Physiol	2010 Dec	Li F	doi: 10.1152/ajpcell.00093.2010
23176121	Role of transcription factor Sp1 and RNA binding protein HuR in the downregulation of Dr+ Escherichia coli receptor protein decay accelerating factor (DAF or CD55) by nitric oxide.	FEBS J	2013 Feb	Banadakoppa M	doi: 10.1111/febs.12073
20798862	Regulation of HuR by DNA Damage Response Kinases.	J Nucleic Acids	2010 Jul 25	Kim HH	doi: 10.4061/2010/981487.
20805360	Polyamines regulate the stability of JunD mRNA by modulating the competitive binding of its 3' untranslated region to HuR and AUF1.	Mol Cell Biol	2010 Nov	Zou T	doi: 10.1128/MCB.00807-10
20739277	Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane.	J Biol Chem	2010 Oct 29	Tholanikunnel BG	doi: 10.1074/jbc.M110.168229
20724828	Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis.	Cell Cycle	2010 Aug 15	Gubin MM	doi: 10.4161/cc.9.16.12711
20675370	FasL expression in activated T lymphocytes involves HuR-mediated stabilization.	J Biol Chem	2010 Oct 8	Drury GL	doi: 10.1074/jbc.M110.137919
20631301	Sirtuin 1 regulation of developmental genes during differentiation of stem cells.	Proc Natl Acad Sci U S A	2010 Aug 3	Calvanese V	doi: 10.1073/pnas.1001399107
20459669	The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitro.	Retrovirology	2010 May 7	Ahn J	doi: 10.1186/1742-4690-7-40.
20438856	Regulation of the expression of inducible nitric oxide synthase.	Nitric Oxide	2010 Sep 15	Pautz A	doi: 10.1016/j.niox.2010.04.007
20370918	The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer.	BMC Cancer	2010 Apr 6	Calaluce R	doi: 10.1186/1471-2407-10-126.
20332085	Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1.	J Biol Chem	2010 May 14	Ziegeler G	doi: 10.1074/jbc.M110.113365
20233590	Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES.	Exp Mol Pathol	2010 Jun	Blume SW	doi: 10.1016/j.yexmp.2010.03.006
20219773	Role of the RNA-binding protein HuR in human renal cell carcinoma.	Carcinogenesis	2010 Jun	Danilin S	doi: 10.1093/carcin/bgq052
24946903	A single element in the 3'UTR of the apical sodium-dependent bile acid transporter controls both stabilization and destabilization of mRNA.	Biochem J	2014 Sep 15	Soler DM	doi: 10.1042/BJ20140070.
28242812	CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype.	Mol Cancer Res	2017 Jun	Lal S	doi: 10.1158/1541-7786.MCR-16-0361
25706256	Targeting the multifaceted HuR protein, benefits and caveats.	Curr Drug Targets	2015	Zucal C	-
25706746	The RNA-binding protein HuR is essential for the B cell antibody response.	Nat Immunol	2015 Apr	Diaz-Munoz MD	doi: 10.1038/ni.3115
25678110	The RNA-binding protein HuR/ELAVL1 regulates IFN--and-beta;mRNA abundance and the type I IFN response.	Eur J Immunol	2015 May	Herdy B	doi: 10.1002/eji.201444979
25663692	Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis.	J Natl Cancer Inst	2015 Feb 6	Kim T	doi: 10.1093/jnci/dju505
25519906	Post-transcriptional regulation of programmed cell death 4 (PDCD4) mRNA by the RNA-binding proteins human antigen R (HuR) and T-cell intracellular antigen 1 (TIA1).	J Biol Chem	2015 Feb 6	Wigington CP	doi: 10.1074/jbc.M114.631937
25526033	Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1.	Oncotarget	2014 Nov 30	Tong X	-
25487676	(1)H, (15)N and (13)C resonance assignments of the RRM1 domain of the key post-transcriptional regulator HuR.	Biomol NMR Assign	2015 Oct	Mujo A	doi: 10.1007/s12104-014-9592-9
25488811	Stress granules are dispensable for mRNA stabilization during cellular stress.	Nucleic Acids Res	2015 Feb 27	Bley N	doi: 10.1093/nar/gku1275
25488815	LKB1 preserves genome integrity by stimulating BRCA1 expression.	Nucleic Acids Res	2015 Jan	Gupta R	doi: 10.1093/nar/gku1294
25328858	HuR controls mitochondrial morphology through the regulation of BclxL translation.	Translation (Austin)	2013 Apr 1	Durie D	-
25301069	Neuroprotection requires the functions of the RNA-binding protein HuR.	Cell Death Differ	2015 May	Skliris A	doi: 10.1038/cdd.2014.158
25320093	Cellular retinoic acid-binding protein 2 inhibits tumor growth by two distinct mechanisms.	J Biol Chem	2014 Dec 5	Vreeland AC	doi: 10.1074/jbc.M114.604041
25189382	microRNA and human inducible nitric oxide synthase.	Vitam Horm	2014	Guo Z	doi: 10.1016/B978-0-12-800254-4.00002-7.
25157170	Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R.	Proc Natl Acad Sci U S A	2014 Sep 9	Kraushar ML	doi: 10.1073/pnas.1408305111
25104461	HuR and post-transcriptional regulation in vascular aging.	Sci China Life Sci	2014 Aug	Wang W	doi: 10.1007/s11427-014-4706-2
25112469	Clinical significance of HuR expression in human malignancy.	Med Oncol	2014 Sep	Kotta-Loizou I	doi: 10.1007/s12032-014-0161-y
25116351	Kruppel -like factor 8 is a stress-responsive transcription factor that regulates expression of HuR.	Cell Physiol Biochem	2014	Govindaraju S	doi: 10.1159/000363019
25018007	Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-kB.	Biochim Biophys Acta	2014 Oct	Hashimoto M	doi: 10.1016/j.bbagen.2014.07.005
24954509	HSF1 regulation of -and-beta;-catenin in mammary cancer cells through control of HuR/elavL1 expression.	Oncogene	2015 Apr 23	Chou SD	doi: 10.1038/onc.2014.177
24769203	Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5'- and 3'-UTRs.	Biochem Biophys Res Commun	2014 May 16	Yasuda M	doi: 10.1016/j.bbrc.2014.04.058
24714527	Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis.	Curr Opin Hematol	2014 May	Chang SH	doi: 10.1097/MOH.0000000000000040.
24719890	Hepatitis B virus X upregulates HuR protein level to stabilize HER2 expression in hepatocellular carcinoma cells.	Biomed Res Int	2014	Hung CM	doi: 10.1155/2014/827415
28196122	Detrimental ELAVL-1/HuR-dependent GSK3-and-beta; mRNA stabilization impairs resolution in acute respiratory distress syndrome.	PLoS One	2017 Feb 14	Hoffman O	doi: 10.1371/journal.pone.0172116
24685524	MiR-291b-3p induces apoptosis in liver cell line NCTC1469 by reducing the level of RNA-binding protein HuR.	Cell Physiol Biochem	2014	Guo J	doi: 10.1159/000358654
24692066	Posttranscriptional control of the chemokine receptor CXCR4 expression in cancer cells.	Carcinogenesis	2014 Sep	Al-Souhibani N	doi: 10.1093/carcin/bgu080
24702436	Sirtuin 1 stabilization by HuR represses TNF--and-alpha;- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro: relevance to human metabolic syndrome.	Clin Sci (Lond)	2014 Oct	Ceolotto G	doi: 10.1042/CS20130439.
24658850	RNA-binding proteins in neurological diseases.	Sci China Life Sci	2014 Apr	Zhou H	-
24622240	Microarray meta-analysis of RNA-binding protein functions in alternative polyadenylation.	PLoS One	2014 Mar 12	Hu W	doi: 10.1371/journal.pone.0090774
24615811	Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines.	Nucleic Acids Res	2014 Apr	Zhang X	doi: 10.1093/nar/gku196
24566137	HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA.	Int J Mol Sci	2014 Feb 20	Zhao W	doi: 10.3390/ijms15022946.
24577238	A recently evolved class of alternative 3'-terminal exons involved in cell cycle regulation by topoisomerase inhibitors.	Nat Commun	2014 Feb 28	Dutertre M	doi: 10.1038/ncomms4395.
24536047	HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells.	Cancer Res	2014 Feb 15	Lal S	doi: 10.1158/0008-5472.CAN-13-1915.
24477678	Conditional knockout of the RNA-binding protein HuR in CD4 T cells reveals a gene dosage effect on cytokine production.	Mol Med	2014 Mar 20	Gubin MM	doi: 10.2119/molmed.2013.00127.
24425803	Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1.	Blood	2014 Feb 27	Li X	doi: 10.1182/blood-2013-09-526962
24431206	HuR and other turnover- and translation-regulatory RNA-binding proteins: implications for the kidney.	Am J Physiol Renal Physiol	2014 Mar 15	Pullmann R Jr	doi: 10.1152/ajprenal.00270.2013
24398589	pp32r1 controls the decay of the RNA-binding protein HuR.	Oncol Rep	2014 Mar	Imamachi K	doi: 10.3892/or.2013.2956
24401661	Global target mRNA specification and regulation by the RNA-binding protein ZFP36.	Genome Biol	2014 Jan 8	Mukherjee N	doi: 10.1186/gb-2014-15-1-r12.
24362034	Inhibition of caspases protects mice from radiation-induced oral mucositis and abolishes the cleavage of RNA-binding protein HuR.	J Biol Chem	2014 Feb 7	Talwar S	doi: 10.1074/jbc.M113.504951
24152440	HuR-regulated mRNAs associated with nuclear hnRNP A1-RNP complexes.	Int J Mol Sci	2013 Oct 11	Papadodima O	doi: 10.3390/ijms141020256.
24106086	Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs.	Nucleic Acids Res	2014 Jan	Yoon JH	doi: 10.1093/nar/gkt903
27609837	RNA-binding protein HuR regulates nuclear import of protein.	J Cell Sci	2016 Nov 1	Zhang W	-
26943573	Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy.	Oncotarget	2016 Apr 19	Huang YH	doi: 10.18632/oncotarget.7840.
23978401	Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR.	Cell Signal	2013 Dec	Schulz S	doi: 10.1016/j.cellsig.2013.08.003
24005720	HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA.	Nat Commun	2013	Dormoy-Raclet V	doi: 10.1038/ncomms3388.
23951323	A novel high throughput biochemical assay to evaluate the HuR protein-RNA complex formation.	PLoS One	2013 Aug 12	D'Agostino VG	doi: 10.1371/journal.pone.0072426
23880304	Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells.	Carcinogenesis	2013 Nov	Sharma A	doi: 10.1093/carcin/bgt207
23889148	HuR cytoplasmic expression is associated with increased cyclin A expression and inferior disease-free survival in patients with gastrointestinal stromal tumours (GISTs).	Histopathology	2013 Oct	Wei YC	doi: 10.1111/his.12148
23894643	Altered regulation of ELAVL1/HuR in HLA-B27-expressing U937 monocytic cells.	PLoS One	2013 Jul 22	Sahlberg AS	doi: 10.1371/journal.pone.0070377
23804758	miR-195 competes with HuR to modulate stim1 mRNA stability and regulate cell migration.	Nucleic Acids Res	2013 Sep	Zhuang R	doi: 10.1093/nar/gkt565
23690404	Upregulation of the host SLC11A1 gene by Clostridium difficile toxin B facilitates glucosylation of Rho GTPases and enhances toxin lethality.	Infect Immun	2013 Aug	Feng Y	doi: 10.1128/IAI.01177-12
23665903	Multiple functions of the RNA-binding protein HuR in cancer progression, treatment responses and prognosis.	Int J Mol Sci	2013 May 10	Wang J	doi: 10.3390/ijms140510015.
23618873	The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP.	Genes Dev	2013 May 1	Zhou HL	doi: 10.1101/gad.215681.113
23528537	Retinoic acid-induced HOXA5 expression is co-regulated by HuR and miR-130a.	Cell Signal	2013 Jun	Yang F	doi: 10.1016/j.cellsig.2013.03.015
23508105	HuR maintains a replicative life span by repressing the ARF tumor suppressor.	Mol Cell Biol	2013 May	Kawagishi H	doi: 10.1128/MCB.01277-12
27328938	Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration.	J Nanobiotechnology	2016 Jun 21	Muralidharan R	doi: 10.1186/s12951-016-0201-1.
27542231	Identification of tumorigenesis-related mRNAs associated with RNA-binding protein HuR in thyroid cancer cells.	Oncotarget	2016 Sep 27	Baldan F	doi: 10.18632/oncotarget.11255.
28272405	PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR.	Nat Commun	2017 Mar 8	Ke Y	doi: 10.1038/ncomms14632.
27221739	Regulation of nucleolin expression by miR-194, miR-206, and HuR.	Mol Cell Biochem	2016 Jun	Bose S	doi: 10.1007/s11010-016-2721-2
26682942	Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells.	J Hypertens	2016 Feb	Aguado A	doi: 10.1097/HJH.0000000000000801.
27215284	The MK2/HuR signaling pathway regulates TNF--and-alpha;-induced ICAM-1 expression by promoting the stabilization of ICAM-1 mRNA.	BMC Pulm Med	2016 May 23	Wu T	doi: 10.1186/s12890-016-0247-8.
27383233	The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex.	Sci Rep	2016 Jul 7	Popovitchenko T	doi: 10.1038/srep28998.
26912347	Essential Roles of RNA-binding Protein HuR in Activation of Hepatic Stellate Cells Induced by Transforming Growth Factor--and-beta;1.	Sci Rep	2016 Feb 25	Ge J	doi: 10.1038/srep22141.
26595526	ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.	Oncotarget	2016 Jan 12	Liwak-Muir U	doi: 10.18632/oncotarget.6363.
26362587	Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer.	Acta Oncol	2016	Elebro J	doi: 10.3109/0284186X.2015.1075663
28124257	3'UTR AU-Rich Elements (AREs) and the RNA-Binding Protein Tristetraprolin (TTP) Are Not Required for the LPS-Mediated Destabilization of Phospholipase-C-and-beta;-2 mRNA in Murine Macrophages.	Inflammation	2017 Apr	Shukla S	doi: 10.1007/s10753-017-0511-y.
27784781	Autotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1.	J Biol Chem	2016 Dec 9	Sun S	-
23572284	Hu/elav RNA-binding protein HuR regulates parathyroid hormone related peptide expression in human lung adenocarcinoma cells.	Histol Histopathol	2013 Sep	Lauriola L	doi: 10.14670/HH-28.1205
27658983	A HuR/TGF--and-beta;1 feedback circuit regulates airway remodeling in airway smooth muscle cells.	Respir Res	2016 Sep 22	Wang N	-
28300326	HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases.	Glia	2017 Jun	Matsye P	doi: 10.1002/glia.23137
27473170	RNA-binding protein HuR and the members of the miR-200 family play an unconventional role in the regulation of c-Jun mRNA.	RNA	2016 Oct	Del Vecchio G	doi: 10.1261/rna.057588.116
27401219	Transcriptome meta-analysis of three follicular compartments and its correlation with ovarian follicle maturity and oocyte developmental competence in cows.	Physiol Genomics	2016 Aug 1	Khan DR	doi: 10.1152/physiolgenomics.00050.2016
27401462	Posttranscriptional regulation of 14-3-3Zeta by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding.	Physiol Rep	2016 Jul	Hansraj NZ	doi: 10.14814/phy2.12858.
27371730	Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy.	Mol Cancer Ther	2016 Sep	Li L	doi: 10.1158/1535-7163.MCT-16-0008
27279905	MiR675-5p Acts on HIF-1-and-alpha; to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma.	Theranostics	2016 May 8	Lo Dico A	doi: 10.7150/thno.14700
27197193	Systematic Analysis of AU-Rich Element Expression in Cancer Reveals Common Functional Clusters Regulated by Key RNA-Binding Proteins.	Cancer Res	2016 Jul 15	Hitti E	doi: 10.1158/0008-5472.CAN-15-3110
27215092	MiR-31 Functions as a Tumor Suppressor in Lung Adenocarcinoma Mainly by Targeting HuR.	Clin Lab	2016	Xu H	-
27158334	The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression.	Am J Transl Res	2016 Feb 15	Huang CY	-
27075229	HuR-regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancer.	Cancer Med	2016 Jul	Chai Y	doi: 10.1002/cam4.710
26874904	PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.	Int J Cancer	2016 Jul 1	Mukherjee J	doi: 10.1002/ijc.30041
26819413	LncRNA OIP5-AS1/cyrano sponges RNA-binding protein HuR.	Nucleic Acids Res	2016 Mar 18	Kim J	doi: 10.1093/nar/gkw017
26764246	Cytoplasmic accumulation of ELAVL1 is an independent predictor of biochemical recurrence associated with genomic instability in prostate cancer.	Prostate	2016 Feb 15	Melling N	doi: 10.1002/pros.23120
26690054	RNA-binding proteins regulate cell respiration and coenzyme Q biosynthesis by post-transcriptional regulation of COQ7.	RNA Biol	2016 Jul 2	Cascajo MV	doi: 10.1080/15476286.2015.1119366
26680741	Long noncoding RNA SPRY4-IT1 regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins.	Mol Biol Cell	2016 Feb 15	Xiao L	doi: 10.1091/mbc.E15-10-0703
26494555	HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration and invasion in lung cancer.	Cancer Gene Ther	2015 Dec	Muralidharan R	doi: 10.1038/cgt.2015.55
26434587	Negative regulation of RNA-binding protein HuR by tumor-suppressor ECRG2.	Oncogene	2016 May 19	Lucchesi C	doi: 10.1038/onc.2015.339
26438598	Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637.	Mol Cell Biol	2015 Dec	Kim Y	doi: 10.1128/MCB.00645-15
26451954	HuR and Ago2 Bind the Internal Ribosome Entry Site of Enterovirus 71 and Promote Virus Translation and Replication.	PLoS One	2015 Oct 9	Lin JY	doi: 10.1371/journal.pone.0140291
26407906	Progress on the relationship between miR-125 family and tumorigenesis.	Exp Cell Res	2015 Dec 10	Yin H	doi: 10.1016/j.yexcr.2015.09.015
26390015	Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation.	PLoS One	2015 Sep 21	Wang Z	doi: 10.1371/journal.pone.0138780
26339049	HuR Displaces Polypyrimidine Tract Binding Protein To Facilitate La Binding to the 3' Untranslated Region and Enhances Hepatitis C Virus Replication.	J Virol	2015 Nov	Shwetha S	doi: 10.1128/JVI.01714-15
26346275	Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma.	EMBO J	2015 Nov 3	Zhang LF	doi: 10.15252/embj.201591803
26320247	B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo.	J Immunol	2015 Oct 1	DeMicco A	doi: 10.4049/jimmunol.1500512
26325091	Induction of VEGFA mRNA translation by CoCl2 mediated by HuR.	RNA Biol	2015	Osera C	doi: 10.1080/15476286.2015.1085276
26245959	HuR Mediates Changes in the Stability of AChR -and-beta;-Subunit mRNAs after Skeletal Muscle Denervation.	J Neurosci	2015 Aug 5	Joassard OR	doi: 10.1523/JNEUROSCI.1043-15.2015.
26189797	RNA-binding protein HuR sequesters microRNA-21 to prevent translation repression of proinflammatory tumor suppressor gene programmed cell death 4.	Oncogene	2016 Mar 31	Poria DK	doi: 10.1038/onc.2015.235
26136338	Role and prognostic significance of the epithelial-mesenchymal transition factor ZEB2 in ovarian cancer.	Oncotarget	2015 Aug 7	Prislei S	-
25992900	Roles of Prolyl Isomerases in RNA-Mediated Gene Expression.	Biomolecules	2015 May 18	Thapar R	doi: 10.3390/biom5020974.
26009192	Post-transcriptional regulation of connexins.	Biochem Soc Trans	2015 Jun	Salat-Canela C	doi: 10.1042/BST20150033.
26013954	Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma.	Lung Cancer	2015 Aug	Vigouroux C	doi: 10.1016/j.lungcan.2015.05.008
25896326	UTRs act as scaffolds to regulate membrane protein localization.'>Alternative 3'UTRs act as scaffolds to regulate membrane protein localization.	Nature	2015 Jun 18	Berkovits BD	doi: 10.1038/nature14321
25841271	NEDDylation in liver cancer: The regulation of the RNA binding protein Hu antigen R.	Pancreatology	2015 Jul	Fernandez-Ramos D	doi: 10.1016/j.pan.2015.03.006
25841336	Dimerization model of the C-terminal RNA Recognition Motif of HuR.	FEBS Lett	2015 Apr 28	Diaz-Quintana A	doi: 10.1016/j.febslet.2015.03.013
25805336	MAP kinase phosphatase-1 expression is regulated by 15-deoxy-delta12,14-prostaglandin J2 via a HuR-dependent post-transcriptional mechanism.	Biochim Biophys Acta	2015 Jun	Woo JH	doi: 10.1016/j.bbagrm.2015.03.004
25808495	Competition between RNA-binding proteins CELF1 and HuR modulates MYC translation and intestinal epithelium renewal.	Mol Biol Cell	2015 May 15	Liu L	doi: 10.1091/mbc.E14-11-1500
25824620	HuR keeps interferon--and-beta; mRNA stable.	Eur J Immunol	2015 May	Takeuchi O	doi: 10.1002/eji.201545616.
27677075	Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis.	Oncotarget	2016 Nov 8	Blanco FF	doi: 10.18632/oncotarget.12189.
28414767	The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro.	PLoS One	2017 Apr 17	Kaur K	doi: 10.1371/journal.pone.0175471
28428272	HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.	Cancer Res	2017 May 1	Lang M	doi: 10.1158/0008-5472.CAN-15-1726
27764700	Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment.	Neoplasia	2016 Nov	Kotta-Loizou I	doi: 10.1016/j.neo.2016.09.002
26920226	Posttranscriptional regulation of FOXO expression: microRNAs and beyond.	Br J Pharmacol	2017 Jun	Urbanek P	doi: 10.1111/bph.13471
28572169	Tumor-targeted Nanoparticle Delivery of HuR siRNA Inhibits Lung Tumor Growth In Vitro and In Vivo By Disrupting the Oncogenic Activity of the RNA-binding Protein HuR.	Mol Cancer Ther	2017 Aug	Muralidharan R	doi: 10.1158/1535-7163.MCT-17-0134
28637868	Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells.	J Biol Chem	2017 Aug 18	Tan S	doi: 10.1074/jbc.M117.780973
28652247	Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells.	Cancer Res	2017 Aug 15	Zarei M	doi: 10.1158/0008-5472.CAN-17-0015
28724967	A balancing act: RNA binding protein HuR/TTP axis in endometriosis patients.	Sci Rep	2017 Jul 19	Khalaj K	doi: 10.1038/s41598-017-06081-7.
28808873	Elevated Hu-Antigen Receptor (HuR) Expression is Associated with Tumor Aggressiveness and Poor Prognosis but not with COX-2 Expression in Invasive Breast Carcinoma Patients.	Pathol Oncol Res	2018 Jul	Giaginis C	doi: 10.1007/s12253-017-0288-1
28835257	Long noncoding RNAs coordinate functions between mitochondria and the nucleus.	Epigenetics Chromatin	2017 Aug 23	Dong Y	doi: 10.1186/s13072-017-0149-x.
28968471	Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells.	PLoS One	2017 Oct 2	Lin GL	doi: 10.1371/journal.pone.0185625
29133460	Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development.	Mol Cell Biol	2018 Jan 16	Peng W	doi: 10.1128/MCB.00427-17
29225167	Adenovirus infection induces HuR relocalization to facilitate virus replication.	Biochem Biophys Res Commun	2018 Jan 8	Jehung JP	doi: 10.1016/j.bbrc.2017.12.036
29393507	The induced RNA-binding protein, HuR, targets 3'-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis.	Clin Exp Immunol	2018 Jun	Ouhara K	doi: 10.1111/cei.13110
29452455	Complex HuR function in pancreatic cancer cells.	Wiley Interdiscip Rev RNA	2018 May	Brody JR	doi: 10.1002/wrna.1469
29492748	Cytoplasmic Hu-Antigen R (HuR) Expression is Associated with Poor Survival in Patients with Surgically Resected Cholangiocarcinoma Treated with Adjuvant Gemcitabine-Based Chemotherapy.	Ann Surg Oncol	2018 May	Toyota K	doi: 10.1245/s10434-018-6392-y
29555726	-and-alpha;4 Coordinates Small Intestinal Epithelium Homeostasis by Regulating Stability of HuR.	Mol Cell Biol	2018 May 15	Chung HK	doi: 10.1128/MCB.00631-17
29760195	Neuron-Specific HuR-Deficient Mice Spontaneously Develop Motor Neuron Disease.	J Immunol	2018 Jul 1	Sun K	doi: 10.4049/jimmunol.1701501
30016500	Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR.	Nucleic Acids Res	2018 Sep 6	Battaglia-Hsu SF	doi: 10.1093/nar/gky634.
30035254	The RNA-Binding Protein HuR Posttranscriptionally Regulates IL-2 Homeostasis and CD4+ Th2 Differentiation.	Immunohorizons	2017 Aug 1	Techasintana P	doi: 10.4049/immunohorizons.1700017.
30081711	Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells.	Autophagy	2018	Zhang Z	doi: 10.1080/15548627.2018.1503146
30154469	BAG3 regulates stability of IL-8 mRNA via interplay between HuR and miR-4312 in PDACs.	Cell Death Dis	2018 Aug 28	Li C	doi: 10.1038/s41419-018-0874-5.
30253276	Rotavirus RNAs sponge host cell RNA binding proteins and interfere with their subcellular localization.	Virology	2018 Dec	Oceguera A	doi: 10.1016/j.virol.2018.09.013
30257985	CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways.	J Cell Sci	2018 Oct 29	Sadej R	doi: 10.1242/jcs.220640.
30266754	RNA-Binding Protein HuR Regulates Both Mutant and Wild-Type IDH1 in IDH1-Mutated Cancer.	Mol Cancer Res	2019 Feb	Zarei M	doi: 10.1158/1541-7786.MCR-18-0557
30314695	Knockout of Raptor destabilizes ornithine decarboxylase mRNA and decreases binding of HuR to the ODC transcript in cells exposed to ultraviolet-B irradiation.	Biochem Biophys Res Commun	2018 Nov 10	Nowotarski SL	doi: 10.1016/j.bbrc.2018.10.019
30370480	Multiple functions of HuR in urinary tumors.	J Cancer Res Clin Oncol	2019 Jan	Zhang F	doi: 10.1007/s00432-018-2778-2
30377250	Regulation of Kv11.1 potassium channel C-terminal isoform expression by the RNA-binding proteins HuR and HuD.	J Biol Chem	2018 Dec 21	Gong Q	doi: 10.1074/jbc.RA118.003720
30395882	Phosphorylation of ELAVL1 (Ser219/Ser316) mediated by PKC is required for erythropoiesis.	Biochim Biophys Acta Mol Cell Res	2019 Feb	Zhou X	doi: 10.1016/j.bbamcr.2018.10.021
30431137	Oncolytic potential of an E4-deficient adenovirus that can recognize the stabilization of AU-rich element containing mRNA in cancer cells.	Oncol Rep	2019 Feb	Yanagawa-Matsuda A	doi: 10.3892/or.2018.6865
30472791	Interleukin-4-induced posttranscriptional gene regulation of CCL26 by the RNA-binding protein HuR in primary human nasal polyp-derived epithelial cells.	Int Forum Allergy Rhinol	2019 Mar	Tian P	doi: 10.1002/alr.22250
30533021	Transcriptome-wide analysis links the short-term expression of the b isoforms of TIA proteins to protective proteostasis-mediated cell quiescence response.	PLoS One	2018 Dec 11	Carrascoso I	doi: 10.1371/journal.pone.0208526
30535889	Oligomeric transition and dynamics of RNA binding by the HuR RRM1 domain in solution.	J Biomol NMR	2018 Dec	Lixa C	doi: 10.1007/s10858-018-0217-y
30612309	Human antigen R and drug resistance in tumors.	Invest New Drugs	2019 Jan 5	Zhou F	doi: 10.1007/s10637-018-00723-x
30843060	HuR in the Medial Prefrontal Cortex is Critical for Stress-Induced Synaptic Dysfunction and Depressive-Like Symptoms in Mice.	Cereb Cortex	2019 Jun 1	He ZX	doi: 10.1093/cercor/bhz036.
30972602	Knocking down raptor in human keratinocytes affects ornithine decarboxylase in a post-transcriptional Manner following ultraviolet B exposure.	Amino Acids	2019 Apr 10	Stump CL	doi: 10.1007/s00726-019-02732-3
30517011	In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9.	Nano Lett	2019 Jan 9	Li Z	doi: 10.1021/acs.nanolett.8b02689
30991885	Anti-cancer effects of the HuR inhibitor, MS-444, in malignant glioma cells.	Cancer Biol Ther	2019	Wang J	doi: 10.1080/15384047.2019.1591673
30996806	Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies.	ACS Med Chem Lett	2019 Jan 21	Della Volpe S	doi: 10.1021/acsmedchemlett.8b00600
31042423	Long noncoding RNAs in intestinal epithelium homeostasis.	Am J Physiol Cell Physiol	2019 Jul 1	Xiao L	doi: 10.1152/ajpcell.00092.2019
31064870	The RNA-Binding Protein HuR Confers Oxaliplatin Resistance of Colorectal Cancer By Upregulating CDC6.	Mol Cancer Ther	2019 Jul	Cai J	doi: 10.1158/1535-7163.MCT-18-0945
31089242	The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells.	Sci Rep	2019 May 14	Allegri L	doi: 10.1038/s41598-019-43894-0.
31103853	Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage.	iScience	2019 May 31	Guha A	doi: 10.1016/j.isci.2019.05.002
31180580	LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR-184 in chronic myelogenous leukaemia cells.	FEBS Lett	2019 Jun 10	Zhang F	doi: 10.1002/1873-3468.13480
31195150	RNA-Binding Protein HuR Regulates Rac1 Nucleocytoplasmic Shuttling Through Nucleophosmin in the Intestinal Epithelium.	Cell Mol Gastroenterol Hepatol	2019 Jun 10	Liu L	doi: 10.1016/j.jcmgh.2019.06.002
31253394	Loss of RNA binding protein, human antigen R enhances mitochondrial elongation by regulating Drp1 expression in SH-SY5Y cells.	Biochem Biophys Res Commun	2019 Aug 27	Bae JE	doi: 10.1016/j.bbrc.2019.06.091
31345103	HuR interacts with lincBRN1a and lincBRN1b during neuronal stem cells differentiation.	RNA Biol	2019 Jul 26:1-15	Carelli S	doi: 10.1080/15476286.2019.1637698
18262561	Clonidine-induced enhancement of iNOS expression involves NF-kappaB.	J Surg Res	2008 Sep	Su NY	doi: 10.1016/j.jss.2007.11.725
17288565	Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes.	FEBS J	2007 Feb	Lin NY	-
22362743	HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA.	Nucleic Acids Res	2012 Jun	Kundu P	doi: 10.1093/nar/gks148
22303360	The functional consequences of relative substrate specificity in complex biochemical systems.	Front Genet	2011 Sep 20	Zeng Y	doi: 10.3389/fgene.2011.00065
20617199	RNAcontext: a new method for learning the sequence and structure binding preferences of RNA-binding proteins.	PLoS Comput Biol	2010 Jul 1	Kazan H	doi: 10.1371/journal.pcbi.1000832.
15863502	An early event in adipogenesis, the nuclear selection of the CCAAT enhancer-binding protein {beta} (C/EBP{beta}) mRNA by HuR and its translocation to the cytosol.	J Biol Chem	2005 Jul 1	Gantt K	-
19124115	Increased cyclooxygenase-2 expression in juvenile polyposis syndrome.	Clin Gastroenterol Hepatol	2009 Jan	van Hattem WA	doi: 10.1016/j.cgh.2008.07.030
17599736	Effects of infliximab therapy on gene expression levels of tumor necrosis factor alpha, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis.	Arthritis Rheum	2007 Jul	Sugihara M	-
20412850	Thy-1 mRNA destabilization by norepinephrine a 3' UTR cAMP responsive decay element and involves RNA binding proteins.	Brain Behav Immun	2010 Oct	LaJevic MD	doi: 10.1016/j.bbi.2010.04.006
10964780	HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities.	Virology	2000 Sep 1	Spangberg K	-
10673359	Tumor antigen HuR binds specifically to one of five protein-binding segments in the 3'-untranslated region of the neurofibromin messenger RNA.	Biochem Biophys Res Commun	2000 Jan 27	Haeussler J	-
16306087	Antagonistic functions of tetradecanoyl phorbol acetate-inducible-sequence 11b and HuR in the hormonal regulation of vascular endothelial growth factor messenger ribonucleic acid stability by adrenocorticotropin.	Mol Endocrinol	2006 Apr	Cherradi N	-
15998523	Expression of p53 in renal carcinoma cells is independent of pVHL.	Mutat Res	2005 Oct 15	Stickle NH	-
15914670	The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation.	Nucleic Acids Res	2005 May 24	Meng Z	-
15459902	Expression of the SH2D1A gene is regulated by a combination of transcriptional and post-transcriptional mechanisms.	Eur J Immunol	2004 Nov	Okamoto S	-
15262445	A modified quantitative EMSA and its application in the study of RNA--protein interactions.	J Biochem Biophys Methods	2004 Aug 31	Li Y	-
23408619	An RNA element in human interleukin 6 confers escape from degradation by the gammaherpesvirus SOX protein.	J Virol	2013 Apr	Hutin S	doi: 10.1128/JVI.00159-13
19949288	Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-alpha mRNA.	Exp Mol Med	2009 Nov 30	Chae MJ	doi: 10.3858/emm.2009.41.11.088.
19805546	Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor.	J Biol Chem	2009 Dec 4	Lu L	doi: 10.1074/jbc.M109.067918
19671677	Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells.	Mol Cancer Res	2009 Aug	Ishimaru D	doi: 10.1158/1541-7786.MCR-08-0476
19647848	The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites.	Virology	2009 Sep 30	Rivas-Aravena A	doi: 10.1016/j.virol.2009.06.050
22983828	HuR-hnRNP interactions and the effect of cellular stress.	Mol Cell Biochem	2013 Jan	Papadopoulou C	doi: 10.1007/s11010-012-1454-0
18831511	Expression of the embryonic lethal abnormal vision-like protein HuR in human mesothelioma: association with cyclooxygenase-2 and prognosis.	Cancer	2008 Nov 15	Stoppoloni D	doi: 10.1002/cncr.23904.
18644987	Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6.	Mol Cancer Res	2008 Jul	Scott GK	doi: 10.1158/1541-7786.MCR-07-2110.
18285462	Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA.	Mol Cell Biol	2008 Apr	Doller A	doi: 10.1128/MCB.01530-07
17626845	FRET-detectable interactions between the ARE binding proteins, HuR and p37AUF1.	RNA	2007 Sep	David PS	-
17581403	Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical carcinoma.	Int J Gynecol Pathol	2007 Jul	Lim SJ	-
17288991	HuR binds to a single site on the C/EBPbeta mRNA of 3T3-L1 adipocytes.	Biochem Biophys Res Commun	2007 Mar 30	Jones H	-
21829725	Functional characterization of the HuR:CD83 mRNA interaction.	PLoS One	2011	Pieper D	doi: 10.1371/journal.pone.0023290
29471005	MiR-155-5p controls colon cancer cell migration via post-transcriptional regulation of Human Antigen R (HuR).	Cancer Lett	2018 May 1	Al-Haidari A	doi: 10.1016/j.canlet.2018.02.026
30015836	Long non-coding RNA SNHG12promotes the proliferation and migration of glioma cells by binding to HuR.	Int J Oncol	2018 Sep	Lei W	doi: 10.3892/ijo.2018.4478
30123777	Viral Apoptosis Evasion via the MAPK Pathway by Use of a Host Long Noncoding RNA.	Front Cell Infect Microbiol	2018 Aug 3	Barichievy S	doi: 10.3389/fcimb.2018.00263
30807648	Cachexia-related long noncoding RNA, CAAlnc1, suppresses adipogenesis by blocking the binding of HuR to adipogenic transcription factor mRNAs.	Int J Cancer	2019 Feb 26	Shen L	doi: 10.1002/ijc.32236

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000407627	ELAVL1-201	6015	-	ENSP00000385269	326 (aa)	-	Q15717
ENST00000593807	ELAVL1-202	856	-	ENSP00000470727	153 (aa)	-	M0QZR9
ENST00000595499	ELAVL1-203	799	-	-	- (aa)	-	-
ENST00000596459	ELAVL1-205	1473	-	ENSP00000472197	326 (aa)	-	Q15717
ENST00000596154	ELAVL1-204	880	-	ENSP00000471011	133 (aa)	-	M0R055

Gene Model

Click here to download ENSG00000066044's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04152	AMPK signaling pathway	KEGG
hsa04657	IL-17 signaling pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000066044's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000066044	ELAVL1	93	30.488	ENSG00000116001	TIA1	88	32.593
ENSG00000066044	ELAVL1	87	41.379	ENSG00000070756	PABPC1	92	41.379
ENSG00000066044	ELAVL1	97	76.948	ENSG00000107105	ELAVL2	100	71.111
ENSG00000066044	ELAVL1	94	32.335	ENSG00000143368	SF3B4	74	34.559
ENSG00000066044	ELAVL1	80	31.148	ENSG00000147140	NONO	53	30.328
ENSG00000066044	ELAVL1	78	43.210	ENSG00000161082	CELF5	53	43.210
ENSG00000066044	ELAVL1	81	32.258	ENSG00000184388	PABPC1L2B	94	32.258
ENSG00000066044	ELAVL1	57	32.184	ENSG00000076053	RBM7	58	32.184
ENSG00000066044	ELAVL1	82	32.800	ENSG00000153250	RBMS1	92	32.110
ENSG00000066044	ELAVL1	97	72.222	ENSG00000162374	ELAVL4	90	70.997
ENSG00000066044	ELAVL1	95	34.146	ENSG00000100461	RBM23	61	34.146
ENSG00000066044	ELAVL1	93	44.444	ENSG00000140488	CELF6	57	40.000
ENSG00000066044	ELAVL1	97	68.923	ENSG00000196361	ELAVL3	90	69.538
ENSG00000066044	ELAVL1	59	30.556	ENSG00000120948	TARDBP	77	30.556
ENSG00000066044	ELAVL1	81	43.210	ENSG00000048740	CELF2	63	43.210
ENSG00000066044	ELAVL1	66	45.205	ENSG00000101489	CELF4	86	35.211
ENSG00000066044	ELAVL1	90	35.632	ENSG00000144642	RBMS3	72	35.632
ENSG00000066044	ELAVL1	52	35.135	ENSG00000130811	EIF3G	64	34.286
ENSG00000066044	ELAVL1	95	36.585	ENSG00000131051	RBM39	67	36.585
ENSG00000066044	ELAVL1	93	30.769	ENSG00000151923	TIAL1	92	32.432
ENSG00000066044	ELAVL1	52	32.500	ENSG00000161547	SRSF2	70	32.500
ENSG00000066044	ELAVL1	81	33.065	ENSG00000090621	PABPC4	97	36.765
ENSG00000066044	ELAVL1	81	32.258	ENSG00000186288	PABPC1L2A	94	32.258
ENSG00000066044	ELAVL1	93	44.444	ENSG00000159409	CELF3	98	35.632
ENSG00000066044	ELAVL1	82	32.099	ENSG00000151846	PABPC3	58	32.099
ENSG00000066044	ELAVL1	51	34.177	ENSG00000147274	RBMX	88	35.484
ENSG00000066044	ELAVL1	75	33.333	ENSG00000099622	CIRBP	98	33.333
ENSG00000066044	ELAVL1	51	35.443	ENSG00000213516	RBMXL1	68	35.443
ENSG00000066044	ELAVL1	83	45.679	ENSG00000149187	CELF1	91	31.461
ENSG00000066044	ELAVL1	82	34.568	ENSG00000101104	PABPC1L	95	30.645
ENSG00000066044	ELAVL1	82	31.707	ENSG00000254535	PABPC4L	86	31.707

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000066044	ELAVL1	99	80.556	ENSAPOG00000001912	-	99	80.938	Acanthochromis_polyacanthus
ENSG00000066044	ELAVL1	100	84.802	ENSAPOG00000002277	elavl1a	94	84.802	Acanthochromis_polyacanthus
ENSG00000066044	ELAVL1	100	99.693	ENSAMEG00000008657	ELAVL1	97	99.693	Ailuropoda_melanoleuca
ENSG00000066044	ELAVL1	100	86.503	ENSACIG00000018226	elavl1a	95	86.503	Amphilophus_citrinellus
ENSG00000066044	ELAVL1	99	79.630	ENSACIG00000000511	-	99	79.938	Amphilophus_citrinellus
ENSG00000066044	ELAVL1	99	80.247	ENSAOCG00000023751	-	95	80.556	Amphiprion_ocellaris
ENSG00000066044	ELAVL1	100	84.802	ENSAOCG00000020018	elavl1a	100	80.368	Amphiprion_ocellaris
ENSG00000066044	ELAVL1	99	80.247	ENSAPEG00000003694	-	99	80.625	Amphiprion_percula
ENSG00000066044	ELAVL1	100	84.802	ENSAPEG00000012830	elavl1a	100	80.368	Amphiprion_percula
ENSG00000066044	ELAVL1	100	85.106	ENSATEG00000007662	elavl1a	94	85.106	Anabas_testudineus
ENSG00000066044	ELAVL1	100	76.994	ENSATEG00000006741	-	85	78.571	Anabas_testudineus
ENSG00000066044	ELAVL1	100	98.773	ENSAPLG00000003139	ELAVL1	100	98.773	Anas_platyrhynchos
ENSG00000066044	ELAVL1	91	96.403	ENSANAG00000027297	-	97	97.122	Aotus_nancymaae
ENSG00000066044	ELAVL1	100	96.319	ENSANAG00000031135	-	100	96.319	Aotus_nancymaae
ENSG00000066044	ELAVL1	100	97.866	ENSANAG00000037170	-	100	97.866	Aotus_nancymaae
ENSG00000066044	ELAVL1	99	79.012	ENSACLG00000019504	-	95	79.321	Astatotilapia_calliptera
ENSG00000066044	ELAVL1	100	86.196	ENSACLG00000009328	elavl1a	100	84.969	Astatotilapia_calliptera
ENSG00000066044	ELAVL1	100	85.276	ENSAMXG00000006391	elavl1b	95	85.276	Astyanax_mexicanus
ENSG00000066044	ELAVL1	100	84.969	ENSAMXG00000031223	elavl1a	95	84.969	Astyanax_mexicanus
ENSG00000066044	ELAVL1	100	99.387	ENSBTAG00000000613	ELAVL1	100	99.387	Bos_taurus
ENSG00000066044	ELAVL1	100	100.000	ENSCJAG00000046587	ELAVL1	100	100.000	Callithrix_jacchus
ENSG00000066044	ELAVL1	98	68.847	ENSCAFG00000024229	-	93	68.847	Canis_familiaris
ENSG00000066044	ELAVL1	100	99.693	ENSCAFG00000018353	-	98	99.693	Canis_familiaris
ENSG00000066044	ELAVL1	100	99.693	ENSCAFG00020022841	-	100	99.693	Canis_lupus_dingo
ENSG00000066044	ELAVL1	100	93.464	ENSCAFG00020026232	-	100	93.464	Canis_lupus_dingo
ENSG00000066044	ELAVL1	100	99.387	ENSCHIG00000014334	ELAVL1	100	99.387	Capra_hircus
ENSG00000066044	ELAVL1	100	100.000	ENSTSYG00000008248	ELAVL1	100	100.000	Carlito_syrichta
ENSG00000066044	ELAVL1	95	95.804	ENSCAPG00000009014	ELAVL1	96	95.804	Cavia_aperea
ENSG00000066044	ELAVL1	95	92.617	ENSCPOG00000011884	ELAVL1	100	92.617	Cavia_porcellus
ENSG00000066044	ELAVL1	100	100.000	ENSCCAG00000025328	ELAVL1	100	100.000	Cebus_capucinus
ENSG00000066044	ELAVL1	100	100.000	ENSCATG00000032090	ELAVL1	100	100.000	Cercocebus_atys
ENSG00000066044	ELAVL1	100	99.693	ENSCLAG00000007826	ELAVL1	100	99.693	Chinchilla_lanigera
ENSG00000066044	ELAVL1	100	100.000	ENSCSAG00000008155	ELAVL1	100	100.000	Chlorocebus_sabaeus
ENSG00000066044	ELAVL1	95	97.436	ENSCHOG00000002832	-	100	97.436	Choloepus_hoffmanni
ENSG00000066044	ELAVL1	95	100.000	ENSCHOG00000006810	-	100	100.000	Choloepus_hoffmanni
ENSG00000066044	ELAVL1	93	98.601	ENSCPBG00000017097	ELAVL1	89	99.254	Chrysemys_picta_bellii
ENSG00000066044	ELAVL1	100	100.000	ENSCANG00000041972	ELAVL1	100	100.000	Colobus_angolensis_palliatus
ENSG00000066044	ELAVL1	100	98.466	ENSCGRG00001013676	Elavl1	100	98.466	Cricetulus_griseus_chok1gshd
ENSG00000066044	ELAVL1	100	98.466	ENSCGRG00000001625	Elavl1	100	98.466	Cricetulus_griseus_crigri
ENSG00000066044	ELAVL1	100	82.371	ENSCSEG00000003608	elavl1a	94	82.371	Cynoglossus_semilaevis
ENSG00000066044	ELAVL1	99	78.462	ENSCSEG00000000688	-	95	78.769	Cynoglossus_semilaevis
ENSG00000066044	ELAVL1	100	85.106	ENSCVAG00000017170	elavl1a	100	85.106	Cyprinodon_variegatus
ENSG00000066044	ELAVL1	99	77.778	ENSCVAG00000016617	-	95	78.086	Cyprinodon_variegatus
ENSG00000066044	ELAVL1	100	81.288	ENSDARG00000101744	elavl1b	100	82.381	Danio_rerio
ENSG00000066044	ELAVL1	100	84.969	ENSDARG00000038695	elavl1a	100	84.969	Danio_rerio
ENSG00000066044	ELAVL1	100	99.693	ENSDNOG00000008797	ELAVL1	100	99.693	Dasypus_novemcinctus
ENSG00000066044	ELAVL1	100	98.466	ENSDORG00000009158	Elavl1	100	98.466	Dipodomys_ordii
ENSG00000066044	ELAVL1	95	100.000	ENSETEG00000012985	ELAVL1	100	100.000	Echinops_telfairi
ENSG00000066044	ELAVL1	100	99.387	ENSEASG00005003790	ELAVL1	100	99.387	Equus_asinus_asinus
ENSG00000066044	ELAVL1	100	99.387	ENSECAG00000019459	ELAVL1	100	99.387	Equus_caballus
ENSG00000066044	ELAVL1	99	84.308	ENSELUG00000003289	-	95	84.308	Esox_lucius
ENSG00000066044	ELAVL1	100	85.583	ENSELUG00000008024	elavl1a	95	85.583	Esox_lucius
ENSG00000066044	ELAVL1	100	99.080	ENSFCAG00000034143	ELAVL1	100	99.080	Felis_catus
ENSG00000066044	ELAVL1	93	98.601	ENSFALG00000011725	ELAVL1	90	88.462	Ficedula_albicollis
ENSG00000066044	ELAVL1	100	99.693	ENSFDAG00000021259	ELAVL1	100	99.693	Fukomys_damarensis
ENSG00000066044	ELAVL1	98	78.931	ENSFHEG00000014715	-	99	78.931	Fundulus_heteroclitus
ENSG00000066044	ELAVL1	100	84.969	ENSFHEG00000015979	elavl1a	99	84.969	Fundulus_heteroclitus
ENSG00000066044	ELAVL1	100	82.012	ENSGMOG00000014835	elavl1a	100	82.012	Gadus_morhua
ENSG00000066044	ELAVL1	92	55.208	ENSGMOG00000014008	-	87	61.538	Gadus_morhua
ENSG00000066044	ELAVL1	100	98.773	ENSGALG00000000726	ELAVL1	100	98.773	Gallus_gallus
ENSG00000066044	ELAVL1	100	85.106	ENSGAFG00000019133	elavl1a	94	85.106	Gambusia_affinis
ENSG00000066044	ELAVL1	98	79.874	ENSGAFG00000000715	-	98	80.189	Gambusia_affinis
ENSG00000066044	ELAVL1	100	83.891	ENSGACG00000010657	elavl1a	100	83.891	Gasterosteus_aculeatus
ENSG00000066044	ELAVL1	98	80.878	ENSGACG00000013329	-	88	81.191	Gasterosteus_aculeatus
ENSG00000066044	ELAVL1	100	99.387	ENSGAGG00000024119	ELAVL1	100	99.387	Gopherus_agassizii
ENSG00000066044	ELAVL1	100	100.000	ENSGGOG00000006100	ELAVL1	100	100.000	Gorilla_gorilla
ENSG00000066044	ELAVL1	100	85.714	ENSHBUG00000007897	elavl1a	100	81.595	Haplochromis_burtoni
ENSG00000066044	ELAVL1	99	79.321	ENSHBUG00000007503	-	95	79.630	Haplochromis_burtoni
ENSG00000066044	ELAVL1	93	94.406	ENSHGLG00000008478	-	82	94.406	Heterocephalus_glaber_female
ENSG00000066044	ELAVL1	100	99.693	ENSHGLG00000016101	ELAVL1	100	99.693	Heterocephalus_glaber_female
ENSG00000066044	ELAVL1	93	94.406	ENSHGLG00100000375	-	82	94.406	Heterocephalus_glaber_male
ENSG00000066044	ELAVL1	100	99.693	ENSHGLG00100007070	ELAVL1	100	99.693	Heterocephalus_glaber_male
ENSG00000066044	ELAVL1	99	76.852	ENSHCOG00000020439	-	90	76.852	Hippocampus_comes
ENSG00000066044	ELAVL1	100	80.061	ENSHCOG00000015240	elavl1a	95	80.061	Hippocampus_comes
ENSG00000066044	ELAVL1	100	81.155	ENSIPUG00000015781	elavl1b	89	81.155	Ictalurus_punctatus
ENSG00000066044	ELAVL1	100	84.404	ENSIPUG00000014082	elavl1a	95	84.404	Ictalurus_punctatus
ENSG00000066044	ELAVL1	100	99.693	ENSSTOG00000009130	ELAVL1	100	99.693	Ictidomys_tridecemlineatus
ENSG00000066044	ELAVL1	100	98.466	ENSJJAG00000015838	Elavl1	100	98.466	Jaculus_jaculus
ENSG00000066044	ELAVL1	98	79.560	ENSKMAG00000006259	-	98	79.874	Kryptolebias_marmoratus
ENSG00000066044	ELAVL1	100	84.195	ENSKMAG00000014042	elavl1a	95	84.195	Kryptolebias_marmoratus
ENSG00000066044	ELAVL1	100	85.410	ENSLBEG00000021924	elavl1a	94	85.410	Labrus_bergylta
ENSG00000066044	ELAVL1	99	79.817	ENSLBEG00000028513	-	90	80.122	Labrus_bergylta
ENSG00000066044	ELAVL1	100	92.945	ENSLACG00000017607	ELAVL1	100	92.378	Latimeria_chalumnae
ENSG00000066044	ELAVL1	100	88.957	ENSLOCG00000000284	elavl1b	95	88.957	Lepisosteus_oculatus
ENSG00000066044	ELAVL1	100	99.693	ENSLAFG00000004219	ELAVL1	100	99.693	Loxodonta_africana
ENSG00000066044	ELAVL1	100	100.000	ENSMFAG00000040787	ELAVL1	100	100.000	Macaca_fascicularis
ENSG00000066044	ELAVL1	100	100.000	ENSMMUG00000006544	ELAVL1	100	100.000	Macaca_mulatta
ENSG00000066044	ELAVL1	100	100.000	ENSMNEG00000028431	ELAVL1	100	100.000	Macaca_nemestrina
ENSG00000066044	ELAVL1	100	100.000	ENSMLEG00000037227	ELAVL1	100	100.000	Mandrillus_leucophaeus
ENSG00000066044	ELAVL1	99	80.247	ENSMAMG00000006701	-	95	80.247	Mastacembelus_armatus
ENSG00000066044	ELAVL1	100	84.802	ENSMAMG00000002385	elavl1a	94	84.802	Mastacembelus_armatus
ENSG00000066044	ELAVL1	100	86.196	ENSMZEG00005015772	elavl1a	94	86.196	Maylandia_zebra
ENSG00000066044	ELAVL1	99	79.321	ENSMZEG00005020865	-	100	80.189	Maylandia_zebra
ENSG00000066044	ELAVL1	97	78.344	ENSMZEG00005020888	-	90	78.662	Maylandia_zebra
ENSG00000066044	ELAVL1	95	98.889	ENSMGAG00000001015	ELAVL1	100	98.889	Meleagris_gallopavo
ENSG00000066044	ELAVL1	100	98.466	ENSMAUG00000000924	Elavl1	100	98.466	Mesocricetus_auratus
ENSG00000066044	ELAVL1	100	100.000	ENSMICG00000009699	ELAVL1	100	100.000	Microcebus_murinus
ENSG00000066044	ELAVL1	100	98.466	ENSMOCG00000014588	Elavl1	100	98.466	Microtus_ochrogaster
ENSG00000066044	ELAVL1	98	80.818	ENSMMOG00000008014	-	100	80.818	Mola_mola
ENSG00000066044	ELAVL1	100	83.742	ENSMMOG00000011938	elavl1a	100	83.742	Mola_mola
ENSG00000066044	ELAVL1	100	99.080	ENSMODG00000005041	ELAVL1	83	99.080	Monodelphis_domestica
ENSG00000066044	ELAVL1	100	85.890	ENSMALG00000010070	elavl1a	100	85.106	Monopterus_albus
ENSG00000066044	ELAVL1	99	79.012	ENSMALG00000021265	-	99	79.688	Monopterus_albus
ENSG00000066044	ELAVL1	100	98.466	MGP_CAROLIEiJ_G0030798	Elavl1	100	98.466	Mus_caroli
ENSG00000066044	ELAVL1	100	98.466	ENSMUSG00000040028	Elavl1	100	98.466	Mus_musculus
ENSG00000066044	ELAVL1	100	98.466	MGP_PahariEiJ_G0021261	Elavl1	100	98.466	Mus_pahari
ENSG00000066044	ELAVL1	100	98.466	MGP_SPRETEiJ_G0031906	Elavl1	100	98.466	Mus_spretus
ENSG00000066044	ELAVL1	100	99.693	ENSMPUG00000007991	ELAVL1	100	99.693	Mustela_putorius_furo
ENSG00000066044	ELAVL1	100	99.387	ENSMLUG00000008101	-	97	99.387	Myotis_lucifugus
ENSG00000066044	ELAVL1	100	74.006	ENSMLUG00000030062	-	93	74.006	Myotis_lucifugus
ENSG00000066044	ELAVL1	100	98.466	ENSNGAG00000019590	Elavl1	100	98.466	Nannospalax_galili
ENSG00000066044	ELAVL1	100	86.196	ENSNBRG00000021290	elavl1a	94	86.196	Neolamprologus_brichardi
ENSG00000066044	ELAVL1	99	79.321	ENSNBRG00000006218	-	95	79.630	Neolamprologus_brichardi
ENSG00000066044	ELAVL1	100	99.387	ENSNLEG00000001325	ELAVL1	100	99.387	Nomascus_leucogenys
ENSG00000066044	ELAVL1	99	82.407	ENSMEUG00000010702	-	100	82.407	Notamacropus_eugenii
ENSG00000066044	ELAVL1	100	99.080	ENSOPRG00000009691	-	100	99.080	Ochotona_princeps
ENSG00000066044	ELAVL1	100	99.693	ENSODEG00000012189	ELAVL1	100	99.693	Octodon_degus
ENSG00000066044	ELAVL1	99	79.321	ENSONIG00000003197	-	95	79.630	Oreochromis_niloticus
ENSG00000066044	ELAVL1	100	86.503	ENSONIG00000001096	elavl1a	93	86.503	Oreochromis_niloticus
ENSG00000066044	ELAVL1	79	92.893	ENSOANG00000014244	ELAVL1	100	92.893	Ornithorhynchus_anatinus
ENSG00000066044	ELAVL1	95	97.260	ENSOANG00000022373	-	97	97.260	Ornithorhynchus_anatinus
ENSG00000066044	ELAVL1	100	99.080	ENSOCUG00000015871	ELAVL1	78	99.080	Oryctolagus_cuniculus
ENSG00000066044	ELAVL1	99	79.077	ENSORLG00000000087	-	90	79.385	Oryzias_latipes
ENSG00000066044	ELAVL1	100	83.891	ENSORLG00000012435	elavl1a	95	83.891	Oryzias_latipes
ENSG00000066044	ELAVL1	99	79.077	ENSORLG00020012447	-	90	79.385	Oryzias_latipes_hni
ENSG00000066044	ELAVL1	100	83.891	ENSORLG00020019326	elavl1a	95	83.891	Oryzias_latipes_hni
ENSG00000066044	ELAVL1	100	83.891	ENSORLG00015016801	elavl1a	95	83.891	Oryzias_latipes_hsok
ENSG00000066044	ELAVL1	99	79.077	ENSORLG00015008332	-	90	79.385	Oryzias_latipes_hsok
ENSG00000066044	ELAVL1	100	83.283	ENSOMEG00000015457	elavl1a	95	83.283	Oryzias_melastigma
ENSG00000066044	ELAVL1	99	78.769	ENSOMEG00000015322	-	93	78.354	Oryzias_melastigma
ENSG00000066044	ELAVL1	100	100.000	ENSOGAG00000012877	ELAVL1	100	100.000	Otolemur_garnettii
ENSG00000066044	ELAVL1	100	99.387	ENSOARG00000003168	ELAVL1	96	99.387	Ovis_aries
ENSG00000066044	ELAVL1	100	100.000	ENSPPAG00000035262	ELAVL1	100	100.000	Pan_paniscus
ENSG00000066044	ELAVL1	100	99.080	ENSPPRG00000002521	ELAVL1	100	99.080	Panthera_pardus
ENSG00000066044	ELAVL1	100	99.080	ENSPTIG00000013602	ELAVL1	100	99.080	Panthera_tigris_altaica
ENSG00000066044	ELAVL1	100	100.000	ENSPTRG00000010413	ELAVL1	100	100.000	Pan_troglodytes
ENSG00000066044	ELAVL1	100	100.000	ENSPANG00000025878	ELAVL1	100	100.000	Papio_anubis
ENSG00000066044	ELAVL1	100	88.344	ENSPKIG00000003894	ELAVL1	95	88.344	Paramormyrops_kingsleyae
ENSG00000066044	ELAVL1	100	88.344	ENSPKIG00000023897	-	95	88.344	Paramormyrops_kingsleyae
ENSG00000066044	ELAVL1	100	99.387	ENSPSIG00000013736	ELAVL1	100	99.387	Pelodiscus_sinensis
ENSG00000066044	ELAVL1	100	80.428	ENSPMGG00000015849	elavl1a	100	80.428	Periophthalmus_magnuspinnatus
ENSG00000066044	ELAVL1	99	74.769	ENSPMGG00000015593	-	99	74.769	Periophthalmus_magnuspinnatus
ENSG00000066044	ELAVL1	100	85.106	ENSPFOG00000014116	elavl1a	94	85.106	Poecilia_formosa
ENSG00000066044	ELAVL1	99	78.704	ENSPFOG00000009739	ELAVL1	95	79.012	Poecilia_formosa
ENSG00000066044	ELAVL1	100	85.106	ENSPLAG00000008127	elavl1a	94	85.106	Poecilia_latipinna
ENSG00000066044	ELAVL1	98	79.874	ENSPLAG00000020810	ELAVL1	98	80.189	Poecilia_latipinna
ENSG00000066044	ELAVL1	98	79.874	ENSPMEG00000000283	ELAVL1	98	80.189	Poecilia_mexicana
ENSG00000066044	ELAVL1	100	85.106	ENSPMEG00000002868	elavl1a	94	85.106	Poecilia_mexicana
ENSG00000066044	ELAVL1	98	80.189	ENSPREG00000005877	-	98	80.503	Poecilia_reticulata
ENSG00000066044	ELAVL1	100	85.106	ENSPREG00000011054	elavl1a	94	85.106	Poecilia_reticulata
ENSG00000066044	ELAVL1	100	100.000	ENSPPYG00000009496	ELAVL1	100	100.000	Pongo_abelii
ENSG00000066044	ELAVL1	95	100.000	ENSPCAG00000016012	ELAVL1	100	100.000	Procavia_capensis
ENSG00000066044	ELAVL1	100	100.000	ENSPCOG00000003300	ELAVL1	100	100.000	Propithecus_coquereli
ENSG00000066044	ELAVL1	100	89.877	ENSPVAG00000002299	ELAVL1	100	89.877	Pteropus_vampyrus
ENSG00000066044	ELAVL1	100	86.196	ENSPNYG00000012769	elavl1a	94	86.196	Pundamilia_nyererei
ENSG00000066044	ELAVL1	99	79.321	ENSPNYG00000013107	-	95	79.630	Pundamilia_nyererei
ENSG00000066044	ELAVL1	100	83.742	ENSPNAG00000010909	elavl1a	100	81.250	Pygocentrus_nattereri
ENSG00000066044	ELAVL1	100	85.583	ENSPNAG00000024381	elavl1b	95	85.583	Pygocentrus_nattereri
ENSG00000066044	ELAVL1	100	98.466	ENSRNOG00000001069	Elavl1	100	98.466	Rattus_norvegicus
ENSG00000066044	ELAVL1	100	98.693	ENSRBIG00000032339	-	100	98.693	Rhinopithecus_bieti
ENSG00000066044	ELAVL1	100	85.621	ENSRBIG00000029014	-	97	90.604	Rhinopithecus_bieti
ENSG00000066044	ELAVL1	100	100.000	ENSRROG00000037769	ELAVL1	100	100.000	Rhinopithecus_roxellana
ENSG00000066044	ELAVL1	100	100.000	ENSSBOG00000028871	ELAVL1	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000066044	ELAVL1	100	99.080	ENSSHAG00000008109	ELAVL1	100	99.080	Sarcophilus_harrisii
ENSG00000066044	ELAVL1	100	87.423	ENSSFOG00015017503	-	95	87.423	Scleropages_formosus
ENSG00000066044	ELAVL1	100	87.423	ENSSFOG00015021786	ELAVL1	95	87.423	Scleropages_formosus
ENSG00000066044	ELAVL1	100	83.587	ENSSMAG00000014763	elavl1a	94	83.587	Scophthalmus_maximus
ENSG00000066044	ELAVL1	99	79.321	ENSSMAG00000014353	-	89	79.630	Scophthalmus_maximus
ENSG00000066044	ELAVL1	99	80.864	ENSSDUG00000015257	-	99	81.562	Seriola_dumerili
ENSG00000066044	ELAVL1	100	85.410	ENSSDUG00000012465	elavl1a	94	85.410	Seriola_dumerili
ENSG00000066044	ELAVL1	99	80.864	ENSSLDG00000019362	-	99	81.562	Seriola_lalandi_dorsalis
ENSG00000066044	ELAVL1	100	85.410	ENSSLDG00000022499	elavl1a	94	85.410	Seriola_lalandi_dorsalis
ENSG00000066044	ELAVL1	100	83.436	ENSSARG00000013091	ELAVL1	100	83.436	Sorex_araneus
ENSG00000066044	ELAVL1	100	98.773	ENSSPUG00000002077	ELAVL1	100	98.773	Sphenodon_punctatus
ENSG00000066044	ELAVL1	99	80.864	ENSSPAG00000011250	-	98	81.505	Stegastes_partitus
ENSG00000066044	ELAVL1	100	83.891	ENSSPAG00000013543	elavl1a	94	83.891	Stegastes_partitus
ENSG00000066044	ELAVL1	100	98.466	ENSSSCG00000013592	ELAVL1	100	98.466	Sus_scrofa
ENSG00000066044	ELAVL1	100	98.773	ENSTGUG00000000118	ELAVL1	100	98.773	Taeniopygia_guttata
ENSG00000066044	ELAVL1	99	77.778	ENSTRUG00000007296	-	89	78.086	Takifugu_rubripes
ENSG00000066044	ELAVL1	100	82.209	ENSTRUG00000023704	elavl1a	95	82.209	Takifugu_rubripes
ENSG00000066044	ELAVL1	100	81.651	ENSTNIG00000019823	elavl1a	100	81.651	Tetraodon_nigroviridis
ENSG00000066044	ELAVL1	99	71.166	ENSTNIG00000004733	-	99	71.166	Tetraodon_nigroviridis
ENSG00000066044	ELAVL1	74	100.000	ENSTBEG00000015038	ELAVL1	76	100.000	Tupaia_belangeri
ENSG00000066044	ELAVL1	100	88.650	ENSTTRG00000010180	ELAVL1	100	88.650	Tursiops_truncatus
ENSG00000066044	ELAVL1	100	99.693	ENSUAMG00000022313	ELAVL1	95	99.693	Ursus_americanus
ENSG00000066044	ELAVL1	100	99.693	ENSUMAG00000014798	ELAVL1	95	99.693	Ursus_maritimus
ENSG00000066044	ELAVL1	82	63.806	ENSVPAG00000005777	-	100	63.806	Vicugna_pacos
ENSG00000066044	ELAVL1	99	56.024	ENSVVUG00000025910	-	79	56.024	Vulpes_vulpes
ENSG00000066044	ELAVL1	95	98.319	ENSVVUG00000003187	-	88	98.319	Vulpes_vulpes
ENSG00000066044	ELAVL1	100	99.693	ENSVVUG00000026988	-	93	99.693	Vulpes_vulpes
ENSG00000066044	ELAVL1	100	93.558	ENSXETG00000008752	elavl1	100	93.558	Xenopus_tropicalis
ENSG00000066044	ELAVL1	100	84.663	ENSXCOG00000014236	elavl1a	100	84.663	Xiphophorus_couchianus
ENSG00000066044	ELAVL1	87	83.459	ENSXCOG00000008068	-	90	83.459	Xiphophorus_couchianus
ENSG00000066044	ELAVL1	99	78.704	ENSXMAG00000030088	-	89	79.012	Xiphophorus_maculatus
ENSG00000066044	ELAVL1	100	84.498	ENSXMAG00000009362	elavl1a	94	84.498	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	19561594.21613615.	IDA	Function
GO:0003725	double-stranded RNA binding	21266579.	IDA	Function
GO:0003729	mRNA binding	10660597.	TAS	Function
GO:0003730	mRNA 3'-UTR binding	26595526.	IDA	Function
GO:0003730	mRNA 3'-UTR binding	-	ISS	Function
GO:0005515	protein binding	14731398.17632515.17932509.18191643.19322201.25416956.26489465.27616329.	IPI	Function
GO:0005634	nucleus	14517288.	IDA	Component
GO:0005654	nucleoplasm	17632515.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	14517288.19029303.	IDA	Component
GO:0005829	cytosol	17632515.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007275	multicellular organism development	9003489.	TAS	Process
GO:0010494	cytoplasmic stress granule	-	ISS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0017091	AU-rich element binding	14517288.14731398.23519412.	IDA	Function
GO:0019901	protein kinase binding	14517288.	IPI	Function
GO:0035198	miRNA binding	26595526.	IDA	Function
GO:0035925	mRNA 3'-UTR AU-rich region binding	8626503.16126846.23056314.26489465.	IDA	Function
GO:0042803	protein homodimerization activity	17632515.	IPI	Function
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0045727	positive regulation of translation	21613615.	IDA	Process
GO:0048255	mRNA stabilization	21613615.	IDA	Process
GO:0048255	mRNA stabilization	19029303.	IMP	Process
GO:0051260	protein homooligomerization	26595526.	IDA	Process
GO:0060965	negative regulation of gene silencing by miRNA	27089893.	IGI	Process
GO:0060965	negative regulation of gene silencing by miRNA	26595526.	IMP	Process
GO:0070935	3'-UTR-mediated mRNA stabilization	14517288.26489465.29180010.	IDA	Process
GO:0070935	3'-UTR-mediated mRNA stabilization	19029303.	IMP	Process
GO:0098794	postsynapse	-	IEA	Component
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:1990904	ribonucleoprotein complex	-	ISS	Component
GO:2000036	regulation of stem cell population maintenance	-	ISS	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

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Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.