EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25532599p21, p53, TP53BP1 and p73 polymorphisms and the risk of gastric cardia adenocarcinoma in a Chinese population.Biomarkers2015 MarShao Adoi: 10.3109/1354750X.2014.996607
19806024DNA damage foci in mitosis are devoid of 53BP1.Cell Cycle2009 Oct 15Nelson G-
2302762853BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-??B through miR-146a.Carcinogenesis2012 DecLi Xdoi: 10.1093/carcin/bgs298
2761351853BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.BMC Cancer2016 Sep 9Hong Rdoi: 10.1186/s12885-016-2754-7.
2893053353BP1: A guardian for centrosomal integrity.Front Biosci (Landmark Ed)2018 Jan 1Kim H-
30002377Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR.Nat Commun2018 Jul 12Wang Jdoi: 10.1038/s41467-018-05174-9.
2226687853BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathway.Oncol Rep2012 AprHong Sdoi: 10.3892/or.2012.1641
2601154253BP1 suppresses epithelial-mesenchymal transition by downregulating ZEB1 through microRNA-200b/429 in breast cancer.Cancer Sci2015 AugKong Xdoi: 10.1111/cas.12699
26615718Functional crosstalk between DNA damage response proteins 53BP1 and BRCA1 regulates double strand break repair choice.Radiother Oncol2016 MayBakr Adoi: 10.1016/j.radonc.2015.11.001
12170762Mutations in the p53 tumor suppressor gene and early onset breast cancer.Cancer Biol Ther2002 Jan-FebLai H-
24681733The staining patterns of 53BP1 nuclear foci and 53BP1 mRNA level are associated with cervical cancer progression and metastasis.Int J Gynecol Pathol2014 MayZhu Hdoi: 10.1097/PGP.0000000000000079.
21635553Genetic polymorphisms of TP53-binding protein 1 (TP53BP1) gene and association with breast cancer risk.APMIS2011 JulNaidu Rdoi: 10.1111/j.1600-0463.2011.02753.x
24603722Lack of association of the TP53BP1 Glu353Asp polymorphism with risk of cancer: a systematic review and meta-analysis.PLoS One2014 Mar 6Liu Ldoi: 10.1371/journal.pone.0090931
22323184The role of ATM and 53BP1 as predictive markers in cervical cancer.Int J Cancer2012 Nov 1Roossink Fdoi: 10.1002/ijc.27488
27466483Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein.Anticancer Res2016 AugTome Y-
12646190P202, an interferon-inducible protein, inhibits E2F1-mediated apoptosis in prostate cancer cells.Biochem Biophys Res Commun2003 Mar 28Yan DH-
27465548DNA repair pathways to regulate response to chemoradiotherapy in patients with locally advanced head and neck cancer.Tumour Biol2016 OctCirauqui B-
26261485Expression of DNA damage checkpoint 53BP1 is correlated with prognosis, cell proliferation and apoptosis in colorectal cancer.Int J Clin Exp Pathol2015 Jun 1Bi J-
24316395Common genetic variants in 53BP1 associated with nonsmall-cell lung cancer risk in Han Chinese.Arch Med Res2014 JanZhang Hdoi: 10.1016/j.arcmed.2013.10.011
17634560Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck.Clin Cancer Res2007 Jul 15Chen K-
26637364High XIST and Low 53BP1 Expression Predict Poor Outcome after High-Dose Alkylating Chemotherapy in Patients with a BRCA1-like Breast Cancer.Mol Cancer Ther2016 JanSchouten PCdoi: 10.1158/1535-7163.MCT-15-0470
20372852Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese population.Oncol Rep2010 MayKiyohara C-
23680719Radiation-dose response of glycophorin A somatic mutation in erythrocytes associated with gene polymorphisms of p53 binding protein 1.Mutat Res2013 Jul 4Yoshida Kdoi: 10.1016/j.mrgentox.2013.05.003
26541290A prospective study on histone γ-H2AX and 53BP1 foci expression in rectal carcinoma patients: correlation with radiation therapy-induced outcome.BMC Cancer2015 Nov 6Djuzenova CSdoi: 10.1186/s12885-015-1890-9.
20686496Genetic variants in the 53BP1 gene and skin cancer risk.J Invest Dermatol2010 DecHe Cdoi: 10.1038/jid.2010.227
24191908BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer.BMC Cancer2013 Nov 5Jacot Wdoi: 10.1186/1471-2407-13-523.
27499037Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer.Int J Oncol2016 OctXiao Ydoi: 10.3892/ijo.2016.3629
2944516553BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process.Nat Commun2018 Feb 14Tiwari Adoi: 10.1038/s41467-018-03098-y.
28475402DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis.Cancer Biol Ther2017 Jun 3De Gregoriis Gdoi: 10.1080/15384047.2017.1323590
30082159Intratumoral heterogeneity for frameshift mutations of TP53BP1 and MFN1 genes in colorectal cancers.Pathol Res Pract2018 SepChoi EJdoi: 10.1016/j.prp.2018.07.024

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1543492385Nonsense_MutationnovelQ26*0.11
BLCAchr1543491709Missense_MutationnovelQ106K0.53
BLCAchr1543492421Nonsense_MutationNAQ14*0.21
BLCAchr1543456066Missense_MutationnovelP843A0.25
BLCAchr1543432291Missense_MutationnovelN1188S0.59
BLCAchr1543491715Missense_MutationnovelI104F0.2
BLCAchr1543491713Missense_MutationnovelI104M0.16
BLCAchr1543447480Missense_MutationnovelP903S0.52
BLCAchr1543438354Missense_Mutationrs200776719R1049Q0.55
BLCAchr1543481013SilentnovelG122G0.47
BLCAchr1543447445SilentNAI914I0.32
BLCAchr1543455930Missense_MutationnovelS888C0.19
BLCAchr1543491688Missense_MutationNAQ113K0.34
BLCAchr1543446486Missense_MutationNAG976R0.29
BLCAchr1543432631Missense_MutationnovelE1075Q0.43
BLCAchr1543456007SilentnovelS862S0.04
BLCAchr1543446418Silentrs45479696A998A0.13
BLCAchr1543420427Missense_MutationNAY1515S0.06
BLCAchr1543413251Missense_MutationnovelG1720W0.13
BLCAchr1543432460Missense_Mutationrs755481776R1132W0.24
BLCAchr1543456566Missense_MutationnovelG676A0.22
BLCAchr1543420320Missense_MutationnovelE1551K0.27
BLCAchr1543415762Missense_MutationnovelP1636S0.4
BLCAchr1543492005Missense_MutationnovelA90S0.3
BLCAchr1543491675Missense_MutationnovelT117I0.1
BLCAchr1543432361Missense_Mutationrs748353199E1165K0.42
BLCAchr1543421927Missense_MutationnovelR1338K0.31
BRCAchr1543447376SilentNAS937S0.2
BRCAchr1543408049SilentNAL1875L0.22
BRCAchr1543413287Frame_Shift_DelnovelD1707Efs*40.06
BRCAchr1543432371Missense_MutationNAL1161F0.29
BRCAchr1543409684Missense_MutationNAG1783A0.24
BRCAchr1543416233Missense_MutationNAI1617S0.43
BRCAchr1543409031SilentNAL1817L0.66
BRCAchr1543492055Missense_MutationnovelR73Q0.12
BRCAchr1543409038Missense_MutationNAY1815C0.43
BRCAchr1543409034SilentNAF1816F0.31
BRCAchr1543493109Intronnovel0.19
BRCAchr1543479886Missense_MutationNAR206W0.22
BRCAchr1543420512Missense_Mutationrs764249410V1487I0.11
BRCAchr1543415674Missense_MutationNAS1665L0.24
BRCAchr1543416366Missense_MutationNAE1573Q0.19
BRCAchr1543456408Missense_MutationNAQ729E0.33
BRCAchr1543415665Missense_MutationNAR1668I0.27
BRCAchr1543409093Frame_Shift_InsNAN1797*0.27
BRCAchr1543456830Missense_MutationnovelG588E0.1
BRCAchr1543456651Missense_Mutationrs45443496M648V0.42
BRCAchr1543408931Missense_MutationnovelG1851R0.07
CESCchr1543475676Missense_MutationnovelS320F0.07
CESCchr1543491709Missense_MutationNAQ106E0.39
CESCchr1543413191Missense_MutationNAT1740A0.44
CESCchr1543408021Frame_Shift_DelnovelL1885Wfs*90.59
CESCchr1543432478Missense_MutationNAE1126Q0.3
CESCchr1543477682Missense_MutationnovelL284R0.18
CESCchr1543446445Missense_MutationNAM989I0.18
CESCchr1543421857Splice_RegionnovelL1361L0.36
CESCchr1543456329Missense_MutationNAS755I0.43
CESCchr1543409050Missense_Mutationrs773338141R1811Q0.27
CESCchr1543455958Missense_MutationNAA879T0.19
CESCchr1543409050Missense_Mutationrs773338141R1811Q0.43
CESCchr15434052673'Flanknovel0.13
CESCchr1543469877Missense_MutationNAS452C0.27
CESCchr1543475601Missense_MutationnovelS345C0.1
CESCchr1543455963Nonsense_MutationNAS877*0.4
CESCchr1543493109Intronnovel0.45
CHOLchr1543474711Frame_Shift_InsnovelI376Nfs*40.28
COADchr1543479447Missense_MutationnovelQ241H0.22
COADchr1543416360Nonsense_MutationNAE1575*0.35
COADchr1543474768Splice_SiteNAX357_splice0.41
COADchr1543480934Missense_MutationNAD149Y0.34
COADchr15434053853'Flanknovel0.26
COADchr1543492305SilentnovelT52T0.18
COADchr1543491754Splice_SitenovelX91_splice0.43
COADchr1543469970Frame_Shift_DelnovelP421Lfs*650.18
COADchr15434052563'Flanknovel0.3
COADchr1543456462Frame_Shift_InsNAE711Rfs*90.37
COADchr1543457062Missense_Mutationrs751008850D511Y0.7
COADchr1543420402Silentrs768334619Y1523Y0.37
COADchr1543477736Missense_MutationnovelP266H0.27
COADchr1543480924Missense_MutationnovelG152A0.05
COADchr1543420626Nonsense_MutationnovelR1449*0.52
COADchr1543421854Splice_SitenovelX1362_splice0.46
COADchr1543432248SilentNAS1202S0.27
COADchr1543407414Missense_MutationNAP1963L0.25
COADchr1543446418Silentrs45479696A998A0.1
COADchr1543420584Frame_Shift_DelnovelD1461Rfs*120.37
COADchr1543491716Frame_Shift_DelnovelI104Sfs*950.74
COADchr1543420327Silentrs371925735S1548S0.18
COADchr1543432528Missense_MutationnovelI1109T0.1
COADchr1543420683Missense_MutationnovelS1430P0.46
COADchr1543420470Missense_MutationnovelF1501V0.31
COADchr1543432635Missense_MutationNAE1073D0.32
COADchr1543456196Missense_MutationNAE799D0.24
COADchr1543456384Nonsense_MutationNAE737*0.18
COADchr1543456605Missense_MutationNAE663G0.19
COADchr1543457165Missense_MutationnovelK476N0.16
COADchr1543492298Nonsense_MutationNAE55*0.21
COADchr15434053373'Flanknovel0.16
COADchr1543492298Nonsense_MutationNAE55*0.38
COADchr1543457016Frame_Shift_DelnovelP526Qfs*60.43
COADchr1543432631Nonsense_MutationnovelE1075*0.28
COADchr1543438354Missense_Mutationrs200776719R1049Q0.24
COADchr15434053093'Flanknovel0.09
COADchr1543413212Missense_Mutationrs764425387A1733T0.39
COADchr1543421963Missense_MutationnovelS1326N0.28
ESCAchr1543456543Missense_MutationnovelM684L0.67
ESCAchr1543456771Nonsense_MutationnovelE608*0.22
GBMchr1543456707Missense_MutationnovelP629L0.56
GBMchr1543416341Missense_MutationnovelY1581F0.05
GBMchr1543428168Nonsense_MutationnovelG1221*0.11
GBMchr1543456622SilentNAE657E0.31
GBMchr1543456819Missense_MutationnovelD592Y0.36
GBMchr1543479445Missense_MutationnovelP242R0.08
GBMchr1543480913Missense_MutationnovelH156N0.11
GBMchr1543421954Missense_MutationnovelS1329T0.33
GBMchr1543481023Splice_SiteNAX119_splice0.19
HNSCchr1543474697Missense_MutationnovelP381S0.31
HNSCchr1543456657Nonsense_MutationnovelE646*0.29
HNSCchr1543474692SilentnovelT382T0.45
HNSCchr1543416252Missense_MutationnovelL1611V0.06
HNSCchr1543441559Frame_Shift_DelNAN1017Mfs*200.19
HNSCchr1543456062Missense_MutationnovelL844S0.36
HNSCchr1543456614Missense_MutationnovelS660L0.23
HNSCchr1543479447SilentnovelQ241Q0.32
HNSCchr1543428074Missense_MutationnovelR1252H0.08
HNSCchr1543428033Missense_MutationnovelE1266K0.31
HNSCchr1543493044Intronnovel0.4
HNSCchr1543408919Missense_MutationnovelE1855K0.19
HNSCchr1543413131Missense_MutationnovelE1760K0.14
HNSCchr1543491700Nonsense_MutationnovelE109*0.36
HNSCchr1543407390Missense_MutationnovelS1971F0.27
HNSCchr1543456828Missense_MutationnovelD589H0.31
HNSCchr1543421144Frame_Shift_DelnovelT1372Qfs*500.1
HNSCchr1543438383Missense_MutationnovelI1039M0.16
HNSCchr1543409010Frame_Shift_InsnovelC1825Lfs*90.12
HNSCchr1543469980Missense_MutationnovelE418K0.14
KIRCchr1543420542Frame_Shift_DelnovelL1477Rfs*80.24
KIRCchr1543420686Frame_Shift_DelnovelN1428Cfs*490.21
KIRCchr1543455993Nonsense_MutationNAS867*0.3
KIRCchr1543432470Frame_Shift_DelnovelE1130Kfs*140.19
KIRCchr1543455963Nonsense_MutationNAS877*0.09
KIRPchr1543456942Missense_MutationNAM551L0.4
KIRPchr1543415483Intronnovel0.25
KIRPchr1543421879Missense_MutationnovelS1354C0.49
KIRPchr1543456039Nonsense_MutationNAQ852*0.38
KIRPchr1543432203SilentNAL1217L0.34
KIRPchr1543432304Missense_MutationnovelT1184A0.34
KIRPchr1543456950Missense_Mutationrs758857922T548M0.36
KIRPchr1543479513SilentNAE219E0.37
KIRPchr1543477744SilentnovelP263P0.34
KIRPchr1543416482Intronnovel0.69
LAMLchr1543493086Intronnovel0.08
LAMLchr1543420666SilentnovelS1435S0.26
LGGchr1543415617Missense_Mutationrs769062157R1684H0.1
LGGchr1543422120Nonsense_MutationNAE1274*0.34
LGGchr1543408907Missense_MutationNAI1859V0.05
LIHCchr1543457213SilentnovelI460I0.26
LIHCchr1543408087Missense_MutationNAQ1863K0.15
LIHCchr1543420434In_Frame_DelnovelA1512del0.5
LIHCchr1543456911Missense_MutationNAP561R0.2
LIHCchr1543456911Missense_MutationNAP561R0.06
LIHCchr1543432482SilentnovelV1124V0.36
LUADchr1543446505SilentnovelG969G0.14
LUADchr1543420352Missense_MutationnovelL1540Q0.16
LUADchr1543479477SilentnovelQ231Q0.43
LUADchr1543479478Missense_MutationnovelQ231L0.43
LUADchr1543438368Frame_Shift_DelnovelI1039Rfs*30.48
LUADchr1543409719Missense_MutationNAF1771L0.24
LUADchr1543432619Missense_MutationNAG1079C0.23
LUADchr1543480955Missense_MutationnovelK142Q0.08
LUADchr1543477659Nonsense_MutationNAQ292*0.08
LUADchr1543432519Missense_Mutationrs139141876P1112L0.23
LUADchr1543456813Missense_MutationNAR594G0.42
LUADchr1543420556Missense_MutationnovelG1472V0.15
LUADchr1543456531Missense_MutationNAP688S0.08
LUADchr1543432421Missense_MutationnovelE1145K0.47
LUADchr1543457069Missense_MutationnovelL508F0.14
LUSCchr1543456591Missense_MutationNAP668S0.38
LUSCchr1543477754Missense_MutationnovelE260G0.45
LUSCchr1543409065Missense_MutationNAA1806V0.13
LUSCchr1543475632Missense_MutationNAP335S0.27
LUSCchr1543420599Missense_Mutationrs746329471R1458C0.13
LUSCchr1543421876Missense_MutationnovelR1355P0.22
LUSCchr1543477673Missense_MutationNAS287I0.5
LUSCchr1543470016Nonsense_MutationNAQ406*0.22
LUSCchr1543421913Missense_MutationNAG1343W0.33
LUSCchr1543491675Missense_MutationnovelT117K0.27
OVchr1543475638In_Frame_DelNAL331_A332del0.38
OVchr1543432384Missense_MutationNAM1157R0.23
OVchr1543474766Frame_Shift_InsnovelN358Afs*610.11
OVchr1543446516Missense_MutationnovelP966T0.05
OVchr1543477691Missense_MutationnovelA281V0.48
OVchr1543422076SilentnovelS1288S0.05
PAADchr1543413232Missense_MutationnovelK1726T0.19
PAADchr1543416318Missense_MutationnovelS1589P0.18
PAADchr1543421073Missense_Mutationrs759716044R1396H0.19
PCPGchr1543420736Splice_SitenovelX1412_splice0.3
PCPGchr15434052213'Flanknovel0.34
PRADchr1543409051Nonsense_Mutationrs745781646R1811*0.15
PRADchr1543408951Missense_Mutationrs756730049R1844H0.18
PRADchr1543416264Missense_MutationNAA1607T0.15
PRADchr1543446419Missense_MutationNAA998V0.51
PRADchr1543456555Nonsense_MutationNAK680*0.07
PRADchr1543422039Frame_Shift_DelnovelD1301Ifs*610.06
PRADchr1543441559Frame_Shift_DelNAN1017Mfs*200.29
PRADchr1543456874Missense_MutationnovelQ573H0.38
PRADchr1543474710Silentrs750254905I376I0.38
READchr1543457099Missense_Mutationrs748115671K498N0.3
READchr1543428117Missense_Mutationrs752274598R1238C0.24
READchr1543447456Nonsense_MutationNAE911*0.25
READchr1543477686Nonsense_MutationNAE283*0.23
READchr1543409050Missense_Mutationrs773338141R1811Q0.38
READchr1543420620Missense_MutationnovelD1451Y0.39
READchr1543428107Missense_MutationnovelR1241I0.4
READchr1543479500Missense_Mutationrs767165113E224K0.46
READchr1543432396Missense_MutationnovelG1153V0.08
READchr1543457111Missense_MutationnovelE494D0.2
READchr15434073383'UTRnovel0.46
SARCchr1543456976Missense_MutationnovelD539E0.09
SARCchr1543493074Intronnovel0.86
SARCchr1543475585SilentnovelL350L0.72
SKCMchr1543421074Missense_Mutationrs764043263R1396C0.33
SKCMchr1543456594Missense_MutationNAI667F0.51
SKCMchr1543447469SilentnovelF906F0.28
SKCMchr1543491752Splice_RegionNAD91D0.42
SKCMchr1543456591Missense_MutationNAP668S0.39
SKCMchr1543457077SilentNAL506L0.28
SKCMchr1543492344SilentNAH39H0.29
SKCMchr1543469903SilentNAF443F0.41
SKCMchr1543446496Missense_MutationNAK972N0.34
SKCMchr1543416472Intronnovel0.19
SKCMchr1543456241SilentNAS784S0.15
SKCMchr1543456663Nonsense_MutationNAQ644*0.19
SKCMchr1543456633Missense_MutationnovelH654Y0.21
SKCMchr1543456634SilentnovelH653H0.21
SKCMchr1543420570SilentNAF1467F0.31
SKCMchr1543421979Missense_MutationNAL1321F0.15
SKCMchr1543420404Missense_MutationnovelY1523H0.3
SKCMchr1543469876Silentrs531062154S452S0.25
SKCMchr1543428100SilentNAI1243I0.31
SKCMchr15434072843'UTRnovel0.67
SKCMchr1543446499SilentnovelG971G0.17
SKCMchr1543457145Missense_MutationNAS483L0.19
SKCMchr1543469906SilentnovelV442V0.41
SKCMchr1543456693Nonsense_MutationNAR634*0.39
SKCMchr1543456092Missense_MutationNAS834F0.43
SKCMchr1543421046Missense_MutationnovelP1405L0.16
SKCMchr1543432438Missense_MutationnovelP1139L0.13
SKCMchr1543456784SilentNAG603G0.39
SKCMchr1543456948Missense_MutationNAE549K0.3
SKCMchr1543456591Missense_MutationNAP668S0.19
SKCMchr1543477655Missense_MutationNAK293M0.15
SKCMchr1543420575Missense_Mutationrs267604218P1466S0.22
SKCMchr1543479892Missense_MutationnovelY204D0.18
SKCMchr1543421061Missense_MutationNAR1400Q0.33
SKCMchr15434073413'UTRrs5336283640.34
SKCMchr1543456591Missense_MutationNAP668S0.33
SKCMchr1543475632Missense_MutationNAP335S0.27
SKCMchr1543420609SilentNAA1454A0.14
SKCMchr1543447474Missense_Mutationrs761309980H905Y0.54
SKCMchr1543456592SilentNAI667I0.42
SKCMchr1543456302Missense_MutationNAP764L0.48
SKCMchr1543456332Missense_MutationNAS754F0.21
SKCMchr1543456945Missense_MutationNAP550S0.31
SKCMchr1543480908Silentrs748514034S157S0.54
SKCMchr1543415642Missense_MutationnovelE1676K0.6
SKCMchr1543408951Missense_Mutationrs756730049R1844H0.34
STADchr1543415617Missense_Mutationrs769062157R1684H0.16
STADchr1543456231Nonsense_MutationnovelC781*0.13
STADchr1543491691Frame_Shift_InsnovelP112Vfs*510.28
STADchr1543432220Frame_Shift_DelnovelD1212Mfs*290.08
STADchr1543456099Frame_Shift_DelnovelQ832Sfs*60.21
STADchr1543441559Frame_Shift_DelNAN1017Mfs*200.15
STADchr1543415681Missense_MutationnovelV1663I0.27
STADchr1543408954Missense_MutationNAY1843C0.13
STADchr1543422012Missense_MutationNAS1310P0.08
STADchr1543441554Missense_MutationNAS1019T0.1
STADchr1543474737In_Frame_DelnovelP367del0.1
STADchr15434073473'UTRrs7455051240.24
STADchr1543420461Missense_MutationNAG1504W0.54
STADchr1543420341Missense_MutationnovelV1544M0.41
STADchr1543456293Missense_MutationNAR767K0.3
STADchr1543456557Missense_MutationNAL679H0.06
STADchr1543456557Missense_MutationnovelL679P0.36
STADchr1543421877Nonsense_Mutationrs773155828R1355*0.29
STADchr1543422038Missense_MutationNAD1301A0.22
STADchr1543456105Frame_Shift_DelnovelS830Ffs*120.28
STADchr1543409743Splice_SiteNAX1764_splice0.36
STADchr1543420659Missense_MutationNAR1438S0.19
STADchr1543456463Frame_Shift_DelNAE711Nfs*120.31
STADchr1543420595Missense_Mutationrs770333392R1459H0.35
STADchr1543432434SilentNAS1140S0.32
STADchr1543492084SilentnovelS63S0.05
STADchr1543456463Frame_Shift_DelNAE711Nfs*120.34
STADchr1543441559Frame_Shift_DelNAN1017Mfs*200.21
TGCTchr1543420626Frame_Shift_DelnovelS1446Efs*290.24
THCAchr1543420633SilentNAS1446S0.42
THCAchr1543416306Nonsense_MutationnovelG1593*0.04
THCAchr1543432191Splice_Regionnovel0.1
THCAchr1543446526SilentNAE962E0.07
THCAchr1543446486Missense_MutationNAG976W0.51
THYMchr1543421877SilentnovelR1355R0.23
UCECchr1543409027Missense_MutationNAL1819F0.4
UCECchr15434053463'Flanknovel0.39
UCECchr1543415665Missense_MutationNAR1668I0.33
UCECchr1543416350Missense_MutationNAR1578I0.33
UCECchr1543409065Missense_MutationNAA1806V0.06
UCECchr1543456384Nonsense_MutationNAE737*0.29
UCECchr1543416675Intronnovel0.19
UCECchr1543415638Missense_Mutationrs555514654R1677Q0.2
UCECchr1543409081Nonsense_MutationnovelQ1801*0.35
UCECchr1543446392Missense_MutationnovelL1007P0.33
UCECchr1543479519Missense_MutationnovelK217N0.05
UCECchr15434054293'Flanknovel0.14
UCECchr15434054303'Flanknovel0.05
UCECchr1543456768Nonsense_MutationnovelE609*0.7
UCECchr1543441557Nonsense_MutationnovelG1018*0.35
UCECchr1543420666SilentnovelS1435S0.23
UCECchr1543480927Missense_MutationnovelS151L0.28
UCECchr1543456031Missense_MutationnovelQ854H0.12
UCECchr1543407410Missense_MutationnovelK1964N0.25
UCECchr1543456471Missense_MutationnovelP708S0.1
UCECchr15434054293'Flanknovel0.13
UCECchr1543438390Missense_MutationnovelS1037I0.12
UCECchr1543492447Missense_MutationNAG5E0.29
UCECchr15434054293'Flanknovel0.29
UCECchr1543415618Missense_MutationNAR1684C0.38
UCECchr1543420402Silentrs768334619Y1523Y0.35
UCECchr1543479419Nonsense_MutationNAE251*0.24
UCECchr1543456847SilentNAN582N0.34
UCECchr1543456972Missense_MutationnovelE541K0.2
UCECchr1543474702Missense_MutationnovelS379N0.09
UCECchr1543420363SilentnovelD1536D0.31
UCECchr1543432455SilentnovelS1133S0.32
UCECchr1543456930Missense_MutationNAL555V0.41
UCECchr1543474719SilentnovelT373T0.4
UCECchr1543415678Missense_MutationnovelL1664I0.33
UCECchr1543456692Missense_Mutationrs201785039R634Q0.51
UCECchr1543456846Missense_MutationnovelD583Y0.1
UCECchr1543470047SilentnovelS395S0.36
UCECchr1543456463Frame_Shift_DelNAE711Nfs*120.19
UCECchr1543421988Missense_MutationnovelG1318R0.51
UCECchr1543441559Frame_Shift_DelNAN1017Mfs*200.29
UCECchr1543416510Intronnovel0.46
UCECchr1543420595Missense_Mutationrs770333392R1459H0.48
UCECchr1543456706Silentrs749593404P629P0.53
UCECchr1543416431Intronnovel0.32
UCECchr1543421979Missense_MutationnovelL1321I0.4
UCECchr1543456552Nonsense_MutationnovelE681*0.16
UCECchr1543470017Frame_Shift_DelnovelQ406Rfs*120.43
UCECchr1543415579Intronnovel0.18
UCECchr1543428033Nonsense_MutationnovelE1266*0.42
UCECchr1543456681Missense_MutationnovelL638F0.08
UCECchr1543457025Missense_MutationnovelS523N0.45
UCECchr1543420647Nonsense_MutationNAR1442*0.43
UCECchr15434054293'Flanknovel0.26
UCECchr15434054303'Flanknovel0.13
UCECchr1543407571Splice_SiteNAX1911_splice0.47
UCECchr1543456706Silentrs749593404P629P0.32
UCECchr1543480967Nonsense_MutationNAE138*0.37
UCECchr15434052833'Flanknovel0.17
UCECchr1543456384Nonsense_MutationNAE737*0.38
UCECchr1543492327Missense_MutationnovelR45Q0.2
UCECchr1543456949Silentrs377485265T548T0.27
UCECchr15434072293'UTRnovel0.2
UCECchr1543416514Intronnovel0.22
UCECchr1543420699Missense_MutationnovelD1424E0.18
UCECchr1543456172SilentnovelE807E0.41
UCECchr15434054153'Flanknovel0.35
UCECchr15434054293'Flanknovel0.11
UCECchr1543416241SilentnovelA1614A0.34
UCECchr1543420677Missense_MutationnovelD1432N0.49
UCECchr1543438354Missense_Mutationrs200776719R1049Q0.37
UCECchr1543407975Missense_MutationnovelV1900A0.24
UCECchr1543420523Missense_MutationnovelG1483V0.26
UCECchr1543408022Missense_MutationnovelF1884L0.13
UCECchr1543413317Nonsense_MutationnovelE1698*0.43
UCECchr1543456487SilentnovelC702C0.45
UCECchr1543457012Missense_MutationnovelK527N0.29
UCECchr1543456819Missense_MutationnovelD592Y0.28
UCECchr1543479910Missense_MutationnovelV198I0.07
UCECchr1543457062Frame_Shift_DelnovelD511Ifs*50.27
UCECchr1543477620Missense_MutationnovelD305Y0.31
UCECchr1543416281Missense_MutationnovelG1601E0.05
UCECchr1543441558Frame_Shift_InsnovelN1017Kfs*80.31
UCECchr1543456947In_Frame_InsnovelE549delinsVK0.05
UCECchr1543456949In_Frame_InsnovelT548_E549insSRFQNVLAFNT0.04
UCECchr1543420467Frame_Shift_DelnovelY1502Tfs*430.25
UCECchr15434054293'Flanknovel0.33
UCECchr1543441557Nonsense_MutationnovelG1018*0.09
UCECchr1543479500Missense_Mutationrs767165113E224K0.18
UCECchr1543432679Splice_SitenovelX1059_splice0.43
UCECchr1543441559Frame_Shift_DelNAN1017Mfs*200.5
UCECchr15434054293'Flanknovel0.23
UCECchr15434054303'Flanknovel0.09
UCECchr1543456150Missense_MutationnovelD815Y0.32
UCECchr1543480977Missense_MutationnovelE134D0.34
UCECchr1543492017Nonsense_MutationNAE86*0.29
UCECchr15434072193'UTRnovel0.26
UCECchr1543407476Silentrs754224762V1942V0.19
UCECchr1543415455Intronnovel0.34
UCECchr1543416573Intronnovel0.2
UCECchr1543421106Missense_MutationnovelI1385T0.22
UCECchr1543446390Missense_MutationnovelE1008K0.25
UCECchr1543477724Missense_MutationnovelV270A0.44
UCECchr1543456384Nonsense_MutationNAE737*0.48
UCECchr1543493128Intronnovel0.32
UCECchr1543446472SilentnovelD980D0.41
UCECchr1543421914Silentrs750634192S1342S0.34
UCECchr1543446411Nonsense_MutationNAE1001*0.32
UVMchr1543480962SilentnovelL139L0.07

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.23330.079424
CESCDEL0.18640.00049652
COADDEL0.34812.3878e-07
GBMDEL0.2083.453e-12
HNSCDEL0.16280.11567
KICHAMP0.25760.21756
KIRPDEL0.10760.2062
LUADDEL0.38376.8561e-07
MESODEL0.27594.5411e-10
PAADDEL0.1250.13216
READDEL0.44240.025797
SARCDEL0.18290.18974
UCECDEL0.23197.1012e-08

Survival Analysis
CancerP-value Q-value
KIRC0.013

Kaplan-Meier Survival Analysis

SKCM0.009

Kaplan-Meier Survival Analysis

COAD0.016

Kaplan-Meier Survival Analysis

BLCA0.043

Kaplan-Meier Survival Analysis

READ0.041

Kaplan-Meier Survival Analysis

LAML0.0097

Kaplan-Meier Survival Analysis

LIHC0.035

Kaplan-Meier Survival Analysis

UVM0.023

Kaplan-Meier Survival Analysis

OV0.018

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000067369 (Gene tree)
Gene ID
7158
Gene Symbol
TP53BP1
Alias
53BP1|p202|TDRD30
Full Name
tumor protein p53 binding protein 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
107,668 bases
Position
chr15:43,403,061-43,510,728
Accession
11999
RBP type
non-canonical RBP
Summary
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30668775Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks.Nucleic Acids Res2019 Apr 23Burger Kdoi: 10.1093/nar/gkz024.
20456414Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.Clin Exp Immunol2010 AugLenert Pdoi: 10.1111/j.1365-2249.2010.04176.x
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000414758TP53BP1-206464--- (aa)--
ENST00000605155TP53BP1-217610--- (aa)--
ENST00000263801TP53BP1-2016346-ENSP000002638011972 (aa)-Q12888
ENST00000417342TP53BP1-207594-ENSP0000039850848 (aa)-H7C151
ENST00000477089TP53BP1-213460--- (aa)--
ENST00000382039TP53BP1-2026015XM_011521985ENSP000003714701927 (aa)XP_011520287A6NNK5
ENST00000476454TP53BP1-2122222--- (aa)--
ENST00000571145TP53BP1-215431--- (aa)--
ENST00000480860TP53BP1-214586--- (aa)--
ENST00000382044TP53BP1-20310384XM_011521986ENSP000003714751977 (aa)XP_011520288Q12888
ENST00000411772TP53BP1-2043976-ENSP00000413010192 (aa)-H7C3N7
ENST00000450115TP53BP1-2106179-ENSP000003934971975 (aa)-Q12888
ENST00000434595TP53BP1-209446-ENSP00000416212149 (aa)-H7C495
ENST00000572085TP53BP1-2165574--- (aa)--
ENST00000467474TP53BP1-211556-ENSP00000471624144 (aa)-M0R142
ENST00000413546TP53BP1-2053143-ENSP000003880281033 (aa)-C9JXV0
ENST00000434561TP53BP1-208613-ENSP00000392048163 (aa)-H7BZY0
Gene Model
Click here to download ENSG00000067369's gene model file
Pathways
Pathway IDPathway NameSource
hsa04621NOD-like receptor signaling pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000067369Attention Deficit Disorder with Hyperactivity9.2670000E-00518937294
ENSG00000067369Triglycerides1E-1527036123
ENSG00000067369Influenza A virus5E-725758998
ENSG00000067369Serologic Tests5E-725758998
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000067369rs24398311543492277CLung cancer in ever smokers28604730[1.07-1.17]1.1158895EFO_0006527|EFO_0001071
ENSG00000067369rs1508443041543434427ATriglycerides27036123[0.05-0.082] unit decrease0.066EFO_0004530
ENSG00000067369rs169577091543410750CAntibody level in response to infection25758998[NR] unit increase1.04EFO_0007034|EFO_0007038
ENSG00000067369rs1905435021543464986CLipoprotein phospholipase A2 activity in cardiovascular disease28753643[4.92-10.3] (nmol/min/ml) decrease7.61EFO_0004746|EFO_0005672|EFO_0001645
ENSG00000067369rs5755052831543411080ATCardiometabolic and hematological traits27668658[0.12-0.2] unit decrease0.16EFO_0004309
ENSG00000067369rs1508443041543434427ATriglycerides29507422unit decrease0.155EFO_0004530
ENSG00000067369rs1508443041543434427ATriglycerides29507422unit decrease0.198EFO_0004530
ENSG00000067369rs1508443041543434427ATriglycerides29507422unit decrease0.16EFO_0004530
ENSG00000067369rs1508443041543434427AHigh density lipoprotein cholesterol levels29507422unit increase0.104EFO_0004612
ENSG00000067369rs1508443041543434427AHigh density lipoprotein cholesterol levels29507422unit increase0.108EFO_0004612
ENSG00000067369rs1508443041543434427?Red blood cell count30595370EFO_0004305
ENSG00000067369rs342128661543410766?Eosinophil counts30595370EFO_0004842
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000067369's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000077DNA damage checkpoint21873635.IBAProcess
GO:0000777condensed chromosome kinetochore-IEAComponent
GO:0000781chromosome, telomeric region15149599.IDAComponent
GO:0000784nuclear chromosome, telomeric region-IEAComponent
GO:0001102RNA polymerase II activating transcription factor binding17805299.IPIFunction
GO:0002039p53 binding14985081.17805299.IPIFunction
GO:0003684damaged DNA binding-IEAFunction
GO:0003712transcription coregulator activity17805299.IMPFunction
GO:0005515protein binding11877378.12607005.15456759.16415788.16901786.17024177.17380123.17500065.17525332.17805299.17925232.18001824.18001825.19124460.19433796.20016603.20075863.20126263.20195357.20347427.21317870.22373579.22621922.22653443.22884692.23333306.23377543.25416956.25837623.28241136.29656893.29789392.IPIFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus28241136.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005657replication fork-IEAComponent
GO:0005737cytoplasm9748285.IDAComponent
GO:0006303double-strand break repair via nonhomologous end joining23333306.23760478.28241136.IDAProcess
GO:0006303double-strand break repair via nonhomologous end joining-TASProcess
GO:0006974cellular response to DNA damage stimulus17500065.28241136.IDAProcess
GO:0016604nuclear body-IDAComponent
GO:0035064methylated histone binding22373579.23760478.28241136.IDAFunction
GO:0035861site of double-strand break23333306.23760478.28241136.IDAComponent
GO:0042162telomeric DNA binding-IEAFunction
GO:0042393histone binding21873635.IBAFunction
GO:0045830positive regulation of isotype switching23345425.IDAProcess
GO:0045830positive regulation of isotype switching23760478.IMPProcess
GO:0045893positive regulation of transcription, DNA-templated9748285.NASProcess
GO:0045944positive regulation of transcription by RNA polymerase II21873635.IBAProcess
GO:0045944positive regulation of transcription by RNA polymerase II17805299.IMPProcess
GO:0051091positive regulation of DNA-binding transcription factor activity17805299.ICProcess
GO:0051260protein homooligomerization23345425.IDAProcess
GO:0061649ubiquitin modification-dependent histone binding23760478.IDAFunction
GO:0071481cellular response to X-ray-IEAProcess
GO:1990391DNA repair complex-IEAComponent
GO:2000042negative regulation of double-strand break repair via homologous recombination23333306.23345425.IDAProcess
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