EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28653606	miR-181a-5p Promotes Proliferation and Invasion and Inhibits Apoptosis of Cervical Cancer Cells via Regulating Inositol Polyphosphate-5-Phosphatase A (INPP5A).	Oncol Res	2018 Jun 11	Yang M	doi: 10.3727/096504017X14982569377511

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr10	132749522	Silent	NA	L246L	0.35
BLCA	chr10	132765791	Missense_Mutation	NA	E308Q	0.24
BLCA	chr10	132777693	Missense_Mutation	rs150382081	R334C	0.34
BLCA	chr10	132749800	Silent	rs149439109	F286F	0.07
BLCA	chr10	132645888	Silent	rs375941297	P46P	0.43
BLCA	chr10	132777742	Missense_Mutation	NA	R350H	0.38
BLCA	chr10	132726825	Missense_Mutation	novel	I218V	0.1	Exo_endo_phos
BLCA	chr10	132697899	Missense_Mutation	NA	P152S	0.27	Exo_endo_phos
BRCA	chr10	132710362	Missense_Mutation	NA	L185F	0.38	Exo_endo_phos
BRCA	chr10	132710409	Silent	NA	S200S	0.41
BRCA	chr10	132708336	Silent	novel	F166F	0.06
BRCA	chr10	132749603	Silent	rs147310419	N273N	0.3
BRCA	chr10	132749800	Silent	rs149439109	F286F	0.45
BRCA	chr10	132650461	Nonsense_Mutation	NA	R88*	0.26	Exo_endo_phos
CESC	chr10	132782874	3'UTR	novel		0.27
CESC	chr10	132782352	3'UTR	novel		1
CESC	chr10	132782072	3'UTR	novel		0.46
CESC	chr10	132765821	Nonsense_Mutation	novel	E318*	0.14
CESC	chr10	132777863	Intron	novel		0.47
CESC	chr10	132780857	Silent	rs200446352	S366S	0.14
CESC	chr10	132690413	Missense_Mutation	NA	L110F	0.3	Exo_endo_phos
COAD	chr10	132690427	Frame_Shift_Del	NA	*N116Tfs25**	0.22	Exo_endo_phos
COAD	chr10	132650419	Nonsense_Mutation	NA	E74*	0.38	Exo_endo_phos
COAD	chr10	132710452	Missense_Mutation	novel	D215N	0.2	Exo_endo_phos
COAD	chr10	132782129	3'UTR	novel		0.25
COAD	chr10	132782179	3'UTR	NA		0.41
COAD	chr10	132782069	3'UTR	rs749141674		0.26
COAD	chr10	132690427	Frame_Shift_Del	NA	*N116Tfs25**	0.52	Exo_endo_phos
COAD	chr10	132780872	Silent	novel	V371V	0.71
COAD	chr10	132690427	Frame_Shift_Del	NA	*N116Tfs25**	0.35	Exo_endo_phos
COAD	chr10	132710445	Silent	rs778625312	Y212Y	0.09
COAD	chr10	132710405	Missense_Mutation	novel	P199H	0.09	Exo_endo_phos
COAD	chr10	132782251	3'UTR	novel		0.31
COAD	chr10	132777690	Missense_Mutation	rs576088004	A333T	0.19
COAD	chr10	132726840	Missense_Mutation	novel	E223K	0.11	Exo_endo_phos
COAD	chr10	132650419	Nonsense_Mutation	NA	E74*	0.38	Exo_endo_phos
COAD	chr10	132781880	Missense_Mutation	rs374027590	R393Q	0.25
GBM	chr10	132780858	Missense_Mutation	novel	E367K	0.42
GBM	chr10	132765807	Missense_Mutation	novel	K313R	0.65
HNSC	chr10	132650505	Splice_Region	novel	T102T	0.47
HNSC	chr10	132749574	Missense_Mutation	novel	V264L	0.28	Exo_endo_phos
HNSC	chr10	132780850	Missense_Mutation	NA	S364L	0.11
HNSC	chr10	132749519	Splice_Region	rs746139002	T245T	0.26
LGG	chr10	132708339	Silent	NA	I167I	0.19
LGG	chr10	132782052	3'UTR	rs752051973		0.38
LIHC	chr10	132710347	Frame_Shift_Del	novel	*L180Wfs2**	0.45	Exo_endo_phos
LIHC	chr10	132781880	Missense_Mutation	rs374027590	R393Q	0.35
LUAD	chr10	132650432	Missense_Mutation	rs766031019	S78I	0.21	Exo_endo_phos
LUAD	chr10	132781879	Nonsense_Mutation	rs201882680	R393*	0.13
LUAD	chr10	132777702	Missense_Mutation	novel	E337K	0.18
LUAD	chr10	132645928	Missense_Mutation	NA	N60H	0.11	Exo_endo_phos
LUAD	chr10	132749518	Missense_Mutation	NA	T245K	0.07	Exo_endo_phos
LUSC	chr10	132749553	Missense_Mutation	NA	A257S	0.14	Exo_endo_phos
LUSC	chr10	132765779	Missense_Mutation	NA	E304Q	0.14
LUSC	chr10	132726900	Missense_Mutation	novel	V243L	0.53	Exo_endo_phos
LUSC	chr10	132749836	Missense_Mutation	NA	N298K	0.2
OV	chr10	132726882	Missense_Mutation	novel	L237M	0.16	Exo_endo_phos
OV	chr10	132726898	Missense_Mutation	novel	V242D	0.1	Exo_endo_phos
PAAD	chr10	132749559	Missense_Mutation	rs752726044	D259N	0.15	Exo_endo_phos
PRAD	chr10	132777742	Missense_Mutation	NA	R350H	0.52
SARC	chr10	132749590	Missense_Mutation	rs201167385	R269L	0.33	Exo_endo_phos
SKCM	chr10	132710398	Missense_Mutation	NA	T197A	0.4	Exo_endo_phos
SKCM	chr10	132765844	Splice_Region	NA	P325P	0.23
SKCM	chr10	132777675	Missense_Mutation	novel	P328S	0.18
SKCM	chr10	132726879	Missense_Mutation	NA	R236W	0.24	Exo_endo_phos
SKCM	chr10	132708345	Silent	rs549435844	T169T	0.22
SKCM	chr10	132749546	Silent	NA	T254T	0.3
SKCM	chr10	132749824	Silent	NA	F294F	0.35
SKCM	chr10	132697913	Silent	novel	F156F	0.56
SKCM	chr10	132781906	Missense_Mutation	NA	H402Y	0.25
SKCM	chr10	132650464	Missense_Mutation	NA	V89F	0.24	Exo_endo_phos
STAD	chr10	132690427	Frame_Shift_Del	NA	*N116Tfs25**	0.22	Exo_endo_phos
STAD	chr10	132749555	Silent	NA	A257A	0.12
STAD	chr10	132697873	Missense_Mutation	rs139296617	T143M	0.37	Exo_endo_phos
STAD	chr10	132749556	Missense_Mutation	rs150116834	A258T	0.31	Exo_endo_phos
STAD	chr10	132645897	Missense_Mutation	NA	M49I	0.32	Exo_endo_phos
STAD	chr10	132782069	3'UTR	rs749141674		0.18
STAD	chr10	132749555	Silent	NA	A257A	0.2
STAD	chr10	132781880	Missense_Mutation	rs374027590	R393Q	0.21
STAD	chr10	132690427	Frame_Shift_Del	NA	*N116Tfs25**	0.16	Exo_endo_phos
STAD	chr10	132777758	Silent	rs752158383	P355P	0.14
STAD	chr10	132749837	Missense_Mutation	NA	G299S	0.14
STAD	chr10	132765830	Missense_Mutation	rs748008299	I321V	0.34
STAD	chr10	132650461	Nonsense_Mutation	NA	R88*	0.07	Exo_endo_phos
UCEC	chr10	132749791	Missense_Mutation	NA	K283N	0.27
UCEC	chr10	132782057	3'UTR	rs554831186		0.26
UCEC	chr10	132726835	Missense_Mutation	rs140446601	R221Q	0.28	Exo_endo_phos
UCEC	chr10	132780892	Missense_Mutation	novel	P378H	0.36
UCEC	chr10	132650446	Nonsense_Mutation	NA	E83*	0.24	Exo_endo_phos
UCEC	chr10	132782754	3'UTR	novel		0.19
UCEC	chr10	132783037	3'UTR	novel		0.33
UCEC	chr10	132782069	3'UTR	rs749141674		0.41
UCEC	chr10	132697901	Silent	rs146475540	P152P	0.38
UCEC	chr10	132783156	3'UTR	novel		0.29
UCEC	chr10	132765811	Silent	novel	D314D	0.45
UCEC	chr10	132607932	Missense_Mutation	rs779584545	K31N	0.13	Exo_endo_phos
UCEC	chr10	132783302	3'UTR	novel		0.23
UCEC	chr10	132782139	3'UTR	novel		0.22
UCEC	chr10	132777689	Silent	rs745845233	D332D	0.27
UCEC	chr10	132697838	Silent	novel	A131A	0.23
UCEC	chr10	132782101	3'UTR	novel		0.24
UCEC	chr10	132783028	3'UTR	novel		0.31
UCEC	chr10	132708329	Missense_Mutation	novel	K164R	0.34	Exo_endo_phos
UCEC	chr10	132749600	Silent	novel	D272D	0.55
UCEC	chr10	132782549	3'UTR	rs553881051		0.38
UCEC	chr10	132777690	Missense_Mutation	rs576088004	A333T	0.4
UCEC	chr10	132783001	3'UTR	novel		0.33
UCEC	chr10	132650439	Silent	rs770270373	A80A	0.51
UCEC	chr10	132697828	Missense_Mutation	novel	R128I	0.52	Exo_endo_phos
UCEC	chr10	132708326	Missense_Mutation	novel	R163K	0.42	Exo_endo_phos
UCEC	chr10	132749559	Missense_Mutation	rs752726044	D259N	0.24	Exo_endo_phos
UCEC	chr10	132782863	3'UTR	novel		0.39
UCEC	chr10	132777694	Missense_Mutation	rs1054655	R334H	0.4
UCEC	chr10	132726839	Silent	rs554890216	F222F	0.34
UCEC	chr10	132781880	Missense_Mutation	rs374027590	R393Q	0.38
UCEC	chr10	132782801	3'UTR	novel		0.49
UCEC	chr10	132782686	3'UTR	novel		0.32
UCEC	chr10	132650476	Missense_Mutation	novel	E93K	0.32	Exo_endo_phos
UCEC	chr10	132726840	Missense_Mutation	novel	E223K	0.09	Exo_endo_phos
UCEC	chr10	132782067	3'UTR	novel		0.3
UCEC	chr10	132650438	Missense_Mutation	rs751524528	A80V	0.48	Exo_endo_phos
UCEC	chr10	132650439	Silent	rs770270373	A80A	0.32
UCEC	chr10	132782723	3'UTR	novel		0.1
UCEC	chr10	132645963	Silent	rs570568882	F71F	0.47
UCEC	chr10	132777852	Intron	rs762513441		0.33
UCEC	chr10	132783302	3'UTR	novel		0.29
UCEC	chr10	132726899	Silent	rs747947118	V242V	0.45
UCEC	chr10	132749604	Missense_Mutation	rs147362550	D274N	0.48	Exo_endo_phos
UCEC	chr10	132690429	Missense_Mutation	novel	K115I	0.03	Exo_endo_phos
UCEC	chr10	132650486	Missense_Mutation	novel	K96T	0.44	Exo_endo_phos
UCEC	chr10	132650462	Missense_Mutation	novel	R88Q	0.22	Exo_endo_phos
UCEC	chr10	132783439	3'UTR	novel		0.09
UCEC	chr10	132782069	3'UTR	rs749141674		0.38
UCS	chr10	132749845	Splice_Region	rs142848612	A301A	0.17
UVM	chr10	132781937	Missense_Mutation	novel	Q412L	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1333	0.19593
BRCA	DEL	0.2333	9.4498e-14
CHOL	DEL	0.1944	0.048655
COAD	DEL	0.1663	9.4741e-07
LGG	DEL	0.2671	4.3789e-20
LIHC	DEL	0.2459	5.7505e-06
LUAD	DEL	0.188	0.032471
PAAD	DEL	0.1141	0.169
READ	DEL	0.2	0.014135
THYM	DEL	0.0407	0.10563
UCS	DEL	0.2679	0.1218

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.008	Kaplan-Meier Survival Analysis
HNSC	0.018	Kaplan-Meier Survival Analysis
SKCM	0.024	Kaplan-Meier Survival Analysis
PRAD	0.025	Kaplan-Meier Survival Analysis
BRCA	0.0016	Kaplan-Meier Survival Analysis
UCEC	0.006	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.04	Kaplan-Meier Survival Analysis
LUAD	0.0019	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000068383 (Gene tree)
Gene ID: 3632
Gene Symbol: INPP5A
Alias: 5PTASE
Full Name: inositol polyphosphate-5-phosphatase A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 245,697 bases
Position: chr10:132,537,784-132,783,480
Accession: 6076
RBP type: canonical RBP
Summary: The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000357583	Exo_endo_phos	PF03372.23	6.2e-20	1	1
ENSP00000357582	Exo_endo_phos	PF03372.23	5e-17	1	1
ENSP00000340707	Exo_endo_phos	PF03372.23	3.8e-15	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000423490	INPP5A-204	416	-	ENSP00000390936	138 (aa)	-	Q5T1B3
ENST00000445580	INPP5A-205	610	-	ENSP00000390749	104 (aa)	-	B1AP38
ENST00000487614	INPP5A-206	870	-	-	- (aa)	-	-
ENST00000342652	INPP5A-201	832	-	ENSP00000340707	278 (aa)	-	H0Y2W5
ENST00000368594	INPP5A-203	2967	XM_017016204	ENSP00000357583	412 (aa)	XP_016871693	Q14642
ENST00000368593	INPP5A-202	1432	XM_017016205	ENSP00000357582	387 (aa)	XP_016871694	Q5T1B5
ENST00000498337	INPP5A-207	565	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000068383's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00562	Inositol phosphate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000068383	Autistic Disorder	8.0093000E-006	-
ENSG00000068383	Autistic Disorder	4.1675000E-005	-
ENSG00000068383	Migraine Disorders	2E-8	27182965
ENSG00000068383	Cholangitis, Sclerosing	1E-8	27992413
ENSG00000068383	Gestational Age	7E-6	27490719
ENSG00000068383	Live Birth	7E-6	27490719
ENSG00000068383	Gestational Age	2E-6	27490719
ENSG00000068383	Live Birth	2E-6	27490719
ENSG00000068383	Gait	3E-6	28077804

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000068383	rs61861422	10	132544853	T	Primary sclerosing cholangitis	27992413	[1.15-1.32]	1.23	EFO_0004268
ENSG00000068383	rs873946	10	132716468	A	Gestational age at birth (child effect)	27490719			EFO_0005112\|EFO_0006921
ENSG00000068383	rs873946	10	132716468	A	Gestational age at birth in labor-initiated deliveries (child effect)	27490719			EFO_0005112\|EFO_0006921
ENSG00000068383	rs1133400	10	132645884	A	Heel bone mineral density	28869591	[0.018-0.042] unit decrease	0.0301746	EFO_0009270
ENSG00000068383	rs1133400	10	132645884	A	Heel bone mineral density	28869591	[0.027-0.043] unit decrease	0.0345878	EFO_0009270
ENSG00000068383	rs1133400	10	132645884	A	Heel bone mineral density	28869591	[0.029-0.051] unit decrease	0.0396647	EFO_0009270
ENSG00000068383	rs7091957	10	132625974	?	Gait speed in old age	28077804	[0.0045-0.0107] m/sec decrease	0.0076	EFO_0007680
ENSG00000068383	rs3793683	10	132754883	?	Migraine	27182965	[1.030-1.063]	1.046	EFO_0003821
ENSG00000068383	rs1133400	10	132645884	?	Heel bone mineral density	30048462	[0.024-0.034] unit decrease	0.0289071	EFO_0009270
ENSG00000068383	rs12770172	10	132686214	A	Systolic blood pressure	30578418	[0.19-0.32] mmHg increase	0.2524	EFO_0006335
ENSG00000068383	rs1133400	10	132645884	A	Heel bone mineral density	30598549	[0.026-0.035] unit decrease	0.0307252	EFO_0009270
ENSG00000068383	rs1133400	10	132645884	A	Systolic blood pressure	30224653	[0.2-0.32] mmHg decrease	0.2607	EFO_0006335
ENSG00000068383	rs1133400	10	132645884	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000068383	rs75523587	10	132600079	?	Cardiovascular disease	30595370			EFO_0000319
ENSG00000068383	rs12412313	10	132643258	A	Pulse pressure	30578418	[0.11-0.2] mmHg increase	0.1541	EFO_0005763
ENSG00000068383	rs1133400	10	132645884	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000068383's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000068383	INPP5A	93	55.325	ENSAPOG00000012131	inpp5l	98	55.325	Acanthochromis_polyacanthus
ENSG00000068383	INPP5A	100	85.593	ENSAPOG00000009000	INPP5A	100	84.262	Acanthochromis_polyacanthus
ENSG00000068383	INPP5A	94	95.866	ENSAMEG00000010595	INPP5A	100	95.866	Ailuropoda_melanoleuca
ENSG00000068383	INPP5A	85	79.487	ENSACIG00000015636	INPP5A	96	66.933	Amphilophus_citrinellus
ENSG00000068383	INPP5A	93	55.091	ENSACIG00000017914	inpp5l	97	55.091	Amphilophus_citrinellus
ENSG00000068383	INPP5A	93	55.065	ENSAOCG00000019168	inpp5l	98	55.065	Amphiprion_ocellaris
ENSG00000068383	INPP5A	100	84.746	ENSAPEG00000006102	INPP5A	100	84.019	Amphiprion_percula
ENSG00000068383	INPP5A	93	55.065	ENSAPEG00000013854	inpp5l	98	55.065	Amphiprion_percula
ENSG00000068383	INPP5A	93	54.026	ENSATEG00000023149	inpp5l	98	54.026	Anabas_testudineus
ENSG00000068383	INPP5A	100	83.293	ENSATEG00000009627	INPP5A	100	83.293	Anabas_testudineus
ENSG00000068383	INPP5A	94	93.282	ENSAPLG00000005286	INPP5A	99	93.282	Anas_platyrhynchos
ENSG00000068383	INPP5A	100	91.505	ENSACAG00000005748	INPP5A	100	91.505	Anolis_carolinensis
ENSG00000068383	INPP5A	100	99.029	ENSANAG00000021985	INPP5A	100	99.029	Aotus_nancymaae
ENSG00000068383	INPP5A	99	48.936	ENSACLG00000010016	inpp5l	97	54.026	Astatotilapia_calliptera
ENSG00000068383	INPP5A	100	78.692	ENSACLG00000017291	INPP5A	100	78.692	Astatotilapia_calliptera
ENSG00000068383	INPP5A	99	60.317	ENSAMXG00000040006	inpp5l	98	52.972	Astyanax_mexicanus
ENSG00000068383	INPP5A	100	82.767	ENSAMXG00000039185	INPP5A	100	82.767	Astyanax_mexicanus
ENSG00000068383	INPP5A	100	95.388	ENSBTAG00000009181	INPP5A	100	95.388	Bos_taurus
ENSG00000068383	INPP5A	88	96.154	ENSCAFG00000011136	INPP5A	100	96.154	Canis_familiaris
ENSG00000068383	INPP5A	100	96.602	ENSCAFG00020019852	INPP5A	100	96.602	Canis_lupus_dingo
ENSG00000068383	INPP5A	100	94.417	ENSCHIG00000016158	INPP5A	100	94.417	Capra_hircus
ENSG00000068383	INPP5A	100	93.720	ENSTSYG00000013399	INPP5A	100	97.802	Carlito_syrichta
ENSG00000068383	INPP5A	94	97.933	ENSCPOG00000015072	INPP5A	99	97.933	Cavia_porcellus
ENSG00000068383	INPP5A	100	89.320	ENSCCAG00000023855	INPP5A	100	98.154	Cebus_capucinus
ENSG00000068383	INPP5A	100	99.757	ENSCATG00000035755	INPP5A	100	99.757	Cercocebus_atys
ENSG00000068383	INPP5A	100	97.816	ENSCLAG00000002531	INPP5A	100	97.816	Chinchilla_lanigera
ENSG00000068383	INPP5A	94	99.742	ENSCSAG00000004369	INPP5A	99	99.742	Chlorocebus_sabaeus
ENSG00000068383	INPP5A	100	92.718	ENSCPBG00000014008	INPP5A	100	92.718	Chrysemys_picta_bellii
ENSG00000068383	INPP5A	95	99.746	ENSCANG00000005983	INPP5A	100	99.746	Colobus_angolensis_palliatus
ENSG00000068383	INPP5A	100	96.845	ENSCGRG00001015561	Inpp5a	100	96.845	Cricetulus_griseus_chok1gshd
ENSG00000068383	INPP5A	94	96.641	ENSCGRG00000007793	Inpp5a	100	96.641	Cricetulus_griseus_crigri
ENSG00000068383	INPP5A	99	61.111	ENSCSEG00000008014	inpp5l	97	53.886	Cynoglossus_semilaevis
ENSG00000068383	INPP5A	100	82.567	ENSCSEG00000010496	INPP5A	100	82.567	Cynoglossus_semilaevis
ENSG00000068383	INPP5A	79	76.829	ENSCVAG00000008169	INPP5A	100	66.484	Cyprinodon_variegatus
ENSG00000068383	INPP5A	93	53.488	ENSCVAG00000000528	inpp5l	98	53.488	Cyprinodon_variegatus
ENSG00000068383	INPP5A	99	66.667	ENSDARG00000053878	inpp5l	99	54.156	Danio_rerio
ENSG00000068383	INPP5A	90	86.898	ENSDNOG00000008808	INPP5A	98	86.898	Dasypus_novemcinctus
ENSG00000068383	INPP5A	91	87.733	ENSDORG00000002805	Inpp5a	94	87.733	Dipodomys_ordii
ENSG00000068383	INPP5A	97	45.545	FBgn0259178	5PtaseI	95	45.524	Drosophila_melanogaster
ENSG00000068383	INPP5A	100	96.602	ENSEASG00005015002	INPP5A	100	96.602	Equus_asinus_asinus
ENSG00000068383	INPP5A	100	96.359	ENSECAG00000015981	INPP5A	100	96.359	Equus_caballus
ENSG00000068383	INPP5A	100	81.356	ENSELUG00000018638	INPP5A	100	79.126	Esox_lucius
ENSG00000068383	INPP5A	99	61.290	ENSELUG00000017062	inpp5l	97	53.786	Esox_lucius
ENSG00000068383	INPP5A	100	95.874	ENSFCAG00000010899	INPP5A	100	95.874	Felis_catus
ENSG00000068383	INPP5A	100	89.078	ENSFALG00000001313	INPP5A	95	89.078	Ficedula_albicollis
ENSG00000068383	INPP5A	100	97.573	ENSFDAG00000010285	INPP5A	100	97.573	Fukomys_damarensis
ENSG00000068383	INPP5A	100	68.966	ENSFHEG00000000519	INPP5A	97	62.283	Fundulus_heteroclitus
ENSG00000068383	INPP5A	93	53.747	ENSFHEG00000020155	inpp5l	98	53.747	Fundulus_heteroclitus
ENSG00000068383	INPP5A	99	46.926	ENSGMOG00000006249	inpp5l	99	49.223	Gadus_morhua
ENSG00000068383	INPP5A	96	93.451	ENSGALG00000010493	INPP5A	100	92.476	Gallus_gallus
ENSG00000068383	INPP5A	74	66.234	ENSGAFG00000002218	INPP5A	99	44.643	Gambusia_affinis
ENSG00000068383	INPP5A	99	61.111	ENSGAFG00000010234	inpp5l	98	51.688	Gambusia_affinis
ENSG00000068383	INPP5A	79	79.268	ENSGACG00000002820	INPP5A	100	69.108	Gasterosteus_aculeatus
ENSG00000068383	INPP5A	99	52.174	ENSGACG00000011085	inpp5l	97	53.766	Gasterosteus_aculeatus
ENSG00000068383	INPP5A	100	92.718	ENSGAGG00000013734	INPP5A	100	92.718	Gopherus_agassizii
ENSG00000068383	INPP5A	99	99.755	ENSGGOG00000034868	INPP5A	100	99.755	Gorilla_gorilla
ENSG00000068383	INPP5A	100	78.450	ENSHBUG00000008724	INPP5A	100	78.450	Haplochromis_burtoni
ENSG00000068383	INPP5A	94	52.747	ENSHBUG00000012395	inpp5l	97	52.747	Haplochromis_burtoni
ENSG00000068383	INPP5A	100	97.087	ENSHGLG00000011306	INPP5A	100	97.087	Heterocephalus_glaber_female
ENSG00000068383	INPP5A	100	97.087	ENSHGLG00100007832	INPP5A	100	97.087	Heterocephalus_glaber_male
ENSG00000068383	INPP5A	93	53.506	ENSHCOG00000002294	inpp5l	98	53.506	Hippocampus_comes
ENSG00000068383	INPP5A	100	84.746	ENSHCOG00000006054	INPP5A	100	82.567	Hippocampus_comes
ENSG00000068383	INPP5A	100	81.553	ENSIPUG00000019113	inpp5a	100	81.553	Ictalurus_punctatus
ENSG00000068383	INPP5A	94	97.933	ENSSTOG00000006754	INPP5A	100	97.933	Ictidomys_tridecemlineatus
ENSG00000068383	INPP5A	100	96.845	ENSJJAG00000017708	Inpp5a	100	96.845	Jaculus_jaculus
ENSG00000068383	INPP5A	93	55.959	ENSKMAG00000005221	inpp5l	98	55.959	Kryptolebias_marmoratus
ENSG00000068383	INPP5A	77	78.750	ENSKMAG00000015822	INPP5A	92	78.814	Kryptolebias_marmoratus
ENSG00000068383	INPP5A	100	83.898	ENSLBEG00000009250	INPP5A	100	82.324	Labrus_bergylta
ENSG00000068383	INPP5A	98	50.000	ENSLBEG00000003528	inpp5l	98	50.518	Labrus_bergylta
ENSG00000068383	INPP5A	99	48.193	ENSLACG00000006453	inpp5l	99	57.880	Latimeria_chalumnae
ENSG00000068383	INPP5A	99	86.131	ENSLACG00000007683	INPP5A	99	86.131	Latimeria_chalumnae
ENSG00000068383	INPP5A	93	53.766	ENSLOCG00000015035	inpp5l	97	53.766	Lepisosteus_oculatus
ENSG00000068383	INPP5A	100	85.680	ENSLOCG00000007409	INPP5A	100	85.680	Lepisosteus_oculatus
ENSG00000068383	INPP5A	97	95.250	ENSLAFG00000018003	INPP5A	96	95.250	Loxodonta_africana
ENSG00000068383	INPP5A	100	99.757	ENSMFAG00000003838	INPP5A	100	99.757	Macaca_fascicularis
ENSG00000068383	INPP5A	98	98.765	ENSMMUG00000003802	INPP5A	95	98.765	Macaca_mulatta
ENSG00000068383	INPP5A	100	99.757	ENSMNEG00000014000	INPP5A	100	99.757	Macaca_nemestrina
ENSG00000068383	INPP5A	99	88.915	ENSMLEG00000005465	INPP5A	99	88.915	Mandrillus_leucophaeus
ENSG00000068383	INPP5A	100	83.898	ENSMAMG00000011199	INPP5A	100	83.293	Mastacembelus_armatus
ENSG00000068383	INPP5A	93	55.352	ENSMAMG00000009026	inpp5l	97	55.352	Mastacembelus_armatus
ENSG00000068383	INPP5A	100	78.692	ENSMZEG00005018019	INPP5A	100	78.692	Maylandia_zebra
ENSG00000068383	INPP5A	83	54.386	ENSMZEG00005011498	inpp5l	93	51.582	Maylandia_zebra
ENSG00000068383	INPP5A	92	88.594	ENSMGAG00000011902	INPP5A	96	88.594	Meleagris_gallopavo
ENSG00000068383	INPP5A	86	94.068	ENSMAUG00000002979	Inpp5a	85	97.351	Mesocricetus_auratus
ENSG00000068383	INPP5A	86	94.068	ENSMICG00000047464	INPP5A	87	95.968	Microcebus_murinus
ENSG00000068383	INPP5A	100	97.087	ENSMOCG00000016229	Inpp5a	100	97.087	Microtus_ochrogaster
ENSG00000068383	INPP5A	93	54.286	ENSMALG00000002989	inpp5l	98	54.286	Monopterus_albus
ENSG00000068383	INPP5A	100	80.508	ENSMALG00000017217	INPP5A	100	79.903	Monopterus_albus
ENSG00000068383	INPP5A	100	97.087	MGP_CAROLIEiJ_G0030617	Inpp5a	100	97.087	Mus_caroli
ENSG00000068383	INPP5A	100	97.087	ENSMUSG00000025477	Inpp5a	100	97.087	Mus_musculus
ENSG00000068383	INPP5A	100	97.087	MGP_PahariEiJ_G0013822	Inpp5a	100	97.087	Mus_pahari
ENSG00000068383	INPP5A	100	97.087	MGP_SPRETEiJ_G0031728	Inpp5a	100	97.087	Mus_spretus
ENSG00000068383	INPP5A	88	94.780	ENSMPUG00000002237	INPP5A	100	94.780	Mustela_putorius_furo
ENSG00000068383	INPP5A	91	95.989	ENSMLUG00000000913	INPP5A	100	95.989	Myotis_lucifugus
ENSG00000068383	INPP5A	100	96.359	ENSNGAG00000021586	Inpp5a	100	96.359	Nannospalax_galili
ENSG00000068383	INPP5A	92	53.581	ENSNBRG00000019304	inpp5l	92	53.581	Neolamprologus_brichardi
ENSG00000068383	INPP5A	91	78.400	ENSNBRG00000019130	INPP5A	99	78.400	Neolamprologus_brichardi
ENSG00000068383	INPP5A	100	92.476	ENSNLEG00000001956	INPP5A	100	92.476	Nomascus_leucogenys
ENSG00000068383	INPP5A	82	92.920	ENSMEUG00000005069	INPP5A	100	77.261	Notamacropus_eugenii
ENSG00000068383	INPP5A	99	81.818	ENSODEG00000001488	-	99	81.818	Octodon_degus
ENSG00000068383	INPP5A	100	97.573	ENSODEG00000017163	-	100	97.573	Octodon_degus
ENSG00000068383	INPP5A	91	78.342	ENSONIG00000007492	INPP5A	100	78.342	Oreochromis_niloticus
ENSG00000068383	INPP5A	97	52.868	ENSONIG00000011646	inpp5l	97	52.868	Oreochromis_niloticus
ENSG00000068383	INPP5A	87	82.405	ENSOANG00000008904	-	100	82.405	Ornithorhynchus_anatinus
ENSG00000068383	INPP5A	100	76.998	ENSORLG00000000540	INPP5A	100	76.998	Oryzias_latipes
ENSG00000068383	INPP5A	99	66.129	ENSORLG00000011507	inpp5l	97	53.906	Oryzias_latipes
ENSG00000068383	INPP5A	99	66.129	ENSORLG00020005731	inpp5l	97	53.906	Oryzias_latipes_hni
ENSG00000068383	INPP5A	100	77.240	ENSORLG00020005329	INPP5A	95	77.240	Oryzias_latipes_hni
ENSG00000068383	INPP5A	100	77.966	ENSORLG00015012220	INPP5A	100	77.966	Oryzias_latipes_hsok
ENSG00000068383	INPP5A	99	64.516	ENSORLG00015020407	inpp5l	97	53.646	Oryzias_latipes_hsok
ENSG00000068383	INPP5A	100	77.966	ENSOMEG00000001808	INPP5A	100	77.966	Oryzias_melastigma
ENSG00000068383	INPP5A	94	53.627	ENSOMEG00000010028	inpp5l	98	53.627	Oryzias_melastigma
ENSG00000068383	INPP5A	91	92.893	ENSOGAG00000003686	INPP5A	100	92.893	Otolemur_garnettii
ENSG00000068383	INPP5A	87	88.889	ENSOARG00000016663	INPP5A	94	80.886	Ovis_aries
ENSG00000068383	INPP5A	96	100.000	ENSPPAG00000042036	INPP5A	100	100.000	Pan_paniscus
ENSG00000068383	INPP5A	100	95.874	ENSPPRG00000003921	INPP5A	100	95.874	Panthera_pardus
ENSG00000068383	INPP5A	86	93.220	ENSPTIG00000013288	INPP5A	89	90.476	Panthera_tigris_altaica
ENSG00000068383	INPP5A	100	99.757	ENSPANG00000020138	INPP5A	100	99.757	Papio_anubis
ENSG00000068383	INPP5A	99	51.064	ENSPKIG00000006809	inpp5l	98	52.987	Paramormyrops_kingsleyae
ENSG00000068383	INPP5A	100	82.524	ENSPKIG00000018494	INPP5A	100	82.524	Paramormyrops_kingsleyae
ENSG00000068383	INPP5A	94	93.540	ENSPSIG00000010759	INPP5A	99	93.540	Pelodiscus_sinensis
ENSG00000068383	INPP5A	97	65.574	ENSPMGG00000011843	inpp5l	99	53.463	Periophthalmus_magnuspinnatus
ENSG00000068383	INPP5A	88	80.495	ENSPMGG00000018608	INPP5A	100	80.495	Periophthalmus_magnuspinnatus
ENSG00000068383	INPP5A	100	96.845	ENSPEMG00000022882	Inpp5a	100	96.845	Peromyscus_maniculatus_bairdii
ENSG00000068383	INPP5A	97	90.274	ENSPCIG00000027916	INPP5A	99	89.831	Phascolarctos_cinereus
ENSG00000068383	INPP5A	99	53.191	ENSPFOG00000012580	inpp5l	97	52.219	Poecilia_formosa
ENSG00000068383	INPP5A	97	53.846	ENSPFOG00000005662	INPP5A	94	55.015	Poecilia_formosa
ENSG00000068383	INPP5A	99	52.128	ENSPLAG00000008222	inpp5l	97	51.958	Poecilia_latipinna
ENSG00000068383	INPP5A	99	65.517	ENSPLAG00000019710	INPP5A	99	54.976	Poecilia_latipinna
ENSG00000068383	INPP5A	97	52.128	ENSPMEG00000000033	inpp5l	97	50.392	Poecilia_mexicana
ENSG00000068383	INPP5A	99	52.128	ENSPREG00000007509	inpp5l	98	51.688	Poecilia_reticulata
ENSG00000068383	INPP5A	100	99.029	ENSPPYG00000002779	INPP5A	100	99.029	Pongo_abelii
ENSG00000068383	INPP5A	100	96.359	ENSPCOG00000015811	INPP5A	100	96.359	Propithecus_coquereli
ENSG00000068383	INPP5A	99	40.663	ENSPNYG00000016213	inpp5l	98	52.396	Pundamilia_nyererei
ENSG00000068383	INPP5A	100	78.692	ENSPNYG00000005824	INPP5A	100	78.692	Pundamilia_nyererei
ENSG00000068383	INPP5A	100	83.981	ENSPNAG00000002313	INPP5A	100	83.981	Pygocentrus_nattereri
ENSG00000068383	INPP5A	99	63.492	ENSPNAG00000017965	inpp5l	98	54.805	Pygocentrus_nattereri
ENSG00000068383	INPP5A	100	97.087	ENSRNOG00000017635	Inpp5a	100	97.087	Rattus_norvegicus
ENSG00000068383	INPP5A	100	99.757	ENSRBIG00000039765	INPP5A	100	99.757	Rhinopithecus_bieti
ENSG00000068383	INPP5A	100	99.757	ENSRROG00000028497	INPP5A	100	99.757	Rhinopithecus_roxellana
ENSG00000068383	INPP5A	96	98.985	ENSSBOG00000010737	INPP5A	100	98.985	Saimiri_boliviensis_boliviensis
ENSG00000068383	INPP5A	93	54.897	ENSSFOG00015010671	inpp5l	97	54.897	Scleropages_formosus
ENSG00000068383	INPP5A	100	83.293	ENSSFOG00015005987	INPP5A	100	83.293	Scleropages_formosus
ENSG00000068383	INPP5A	100	83.051	ENSSMAG00000014975	INPP5A	100	83.051	Scophthalmus_maximus
ENSG00000068383	INPP5A	99	58.571	ENSSMAG00000006387	inpp5l	98	53.627	Scophthalmus_maximus
ENSG00000068383	INPP5A	93	54.805	ENSSDUG00000020644	inpp5l	98	54.805	Seriola_dumerili
ENSG00000068383	INPP5A	100	84.019	ENSSDUG00000020408	INPP5A	100	84.019	Seriola_dumerili
ENSG00000068383	INPP5A	93	53.766	ENSSLDG00000009526	inpp5l	98	53.766	Seriola_lalandi_dorsalis
ENSG00000068383	INPP5A	100	84.746	ENSSLDG00000021836	INPP5A	100	83.777	Seriola_lalandi_dorsalis
ENSG00000068383	INPP5A	86	92.373	ENSSPUG00000005746	INPP5A	100	90.110	Sphenodon_punctatus
ENSG00000068383	INPP5A	93	55.325	ENSSPAG00000023333	inpp5l	98	55.325	Stegastes_partitus
ENSG00000068383	INPP5A	100	85.593	ENSSPAG00000021504	INPP5A	100	83.293	Stegastes_partitus
ENSG00000068383	INPP5A	100	95.146	ENSSSCG00000010765	INPP5A	100	95.146	Sus_scrofa
ENSG00000068383	INPP5A	91	92.533	ENSTGUG00000011675	INPP5A	100	92.533	Taeniopygia_guttata
ENSG00000068383	INPP5A	100	82.082	ENSTRUG00000009619	INPP5A	100	82.082	Takifugu_rubripes
ENSG00000068383	INPP5A	93	52.821	ENSTRUG00000004476	inpp5l	98	52.821	Takifugu_rubripes
ENSG00000068383	INPP5A	99	51.179	ENSTNIG00000006284	inpp5l	99	51.415	Tetraodon_nigroviridis
ENSG00000068383	INPP5A	95	80.513	ENSTNIG00000017087	INPP5A	100	80.513	Tetraodon_nigroviridis
ENSG00000068383	INPP5A	100	95.874	ENSUAMG00000021097	INPP5A	100	95.874	Ursus_americanus
ENSG00000068383	INPP5A	94	95.866	ENSUMAG00000010008	INPP5A	98	95.866	Ursus_maritimus
ENSG00000068383	INPP5A	91	90.909	ENSVVUG00000001099	INPP5A	95	90.909	Vulpes_vulpes
ENSG00000068383	INPP5A	86	83.898	ENSXETG00000023608	inpp5a.1	100	79.710	Xenopus_tropicalis
ENSG00000068383	INPP5A	96	47.987	ENSXCOG00000006499	INPP5A	93	47.409	Xiphophorus_couchianus
ENSG00000068383	INPP5A	99	59.048	ENSXMAG00000007542	INPP5A	99	59.286	Xiphophorus_maculatus
ENSG00000068383	INPP5A	99	52.128	ENSXMAG00000017264	inpp5l	98	51.948	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004445	inositol-polyphosphate 5-phosphatase activity	21873635.	IBA	Function
GO:0004445	inositol-polyphosphate 5-phosphatase activity	8006039.	NAS	Function
GO:0005515	protein binding	8999861.	IPI	Function
GO:0005886	plasma membrane	-	TAS	Component
GO:0016020	membrane	8006039.	NAS	Component
GO:0042731	PH domain binding	8999861.	IPI	Function
GO:0043647	inositol phosphate metabolic process	-	TAS	Process
GO:0046855	inositol phosphate dephosphorylation	21873635.	IBA	Process
GO:0046856	phosphatidylinositol dephosphorylation	-	IEA	Process
GO:0048016	inositol phosphate-mediated signaling	21873635.	IBA	Process
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	-	IEA	Function
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.