EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25119009	The comparison of nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) with Ki67 proliferation marker expression in common skin tumors.	Pol J Pathol	2014 Mar	Zduniak K	-
26323318	NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.	Nucleic Acids Res	2015 Nov 16	Parplys AC	doi: 10.1093/nar/gkv859
28877654	NUCKS nuclear elevated expression indicates progression and prognosis of ovarian cancer.	Tumour Biol	2017 Sep	Shi C	doi: 10.1177/1010428317714631.
23065711	Identification of NUCKS1 as a colorectal cancer prognostic marker through integrated expression and copy number analysis.	Int J Cancer	2013 May 15	Kikuchi A	doi: 10.1002/ijc.27911
20069058	Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breast.	J Biomed Biotechnol	2009	Zi??kowski P	doi: 10.1155/2009/919645
24568505	Effect of NUCKS-1 overexpression on cytokine profiling in obese women with breast cancer.	Asian Pac J Cancer Prev	2014	Soliman NA	-
26989074	MicroRNA-137 inhibits tumor growth and sensitizes chemosensitivity to paclitaxel and cisplatin in lung cancer.	Oncotarget	2016 Apr 12	Shen H	doi: 10.18632/oncotarget.8011.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BRCA	chr1	205718337	Silent	novel	P225P	0.18
BRCA	chr1	205750235	5'UTR	novel		0.31
BRCA	chr1	205718377	Missense_Mutation	rs771629435	P212L	0.12
BRCA	chr1	205720627	Missense_Mutation	NA	H86Y	0.3
BRCA	chr1	205718228	3'UTR	novel		0.46
CESC	chr1	205750000	5'UTR	rs375214915		0.43
CESC	chr1	205717936	3'UTR	novel		0.33
CESC	chr1	205719618	Silent	rs567889157	G147G	0.33
CESC	chr1	205749974	5'UTR	novel		0.33
CESC	chr1	205717994	3'UTR	novel		0.09
COAD	chr1	205718212	3'UTR	novel		0.36
COAD	chr1	205717978	3'UTR	novel		0.4
COAD	chr1	205723951	Silent	novel	T68T	0.36
COAD	chr1	205718238	3'UTR	novel		0.25
COAD	chr1	205720609	Missense_Mutation	rs754971187	Q92K	0.39
COAD	chr1	205727784	Missense_Mutation	rs762593780	S30L	0.08
COAD	chr1	205723937	Missense_Mutation	NA	S73Y	0.35
COAD	chr1	205727783	Silent	rs775426197	S30S	0.34
ESCA	chr1	205718228	3'UTR	novel		0.41
HNSC	chr1	205718238	3'UTR	novel		0.29
HNSC	chr1	205720531	Missense_Mutation	novel	E118Q	0.3
KIRC	chr1	205718205	3'UTR	novel		0.09
LAML	chr1	205720603	Nonsense_Mutation	novel	Q94*	0.21
LIHC	chr1	205750089	5'UTR	novel		0.1
LUAD	chr1	205723935	Missense_Mutation	NA	H74Y	0.1
LUAD	chr1	205719617	Missense_Mutation	NA	S148R	0.44
LUAD	chr1	205718306	Missense_Mutation	novel	D236H	0.15
LUAD	chr1	205727749	Nonsense_Mutation	NA	R42*	0.12
LUAD	chr1	205727776	Missense_Mutation	novel	P33A	0.31
LUAD	chr1	205720543	Missense_Mutation	NA	E114K	0.08
LUSC	chr1	205718475	Silent	rs140739406	T179T	0.13
LUSC	chr1	205749975	5'UTR	novel		0.25
LUSC	chr1	205719662	Missense_Mutation	novel	D133Y	0.14
LUSC	chr1	205718359	Missense_Mutation	NA	K218R	0.42
OV	chr1	205720577	Missense_Mutation	novel	K102N	0.31
OV	chr1	205718262	3'UTR	novel		0.09
PCPG	chr1	205718394	Silent	rs770672139	K206K	0.36
READ	chr1	205719612	Silent	rs753207169	S149S	0.17
READ	chr1	205723975	Silent	novel	D60D	0.05
READ	chr1	205729600	Nonsense_Mutation	novel	Y13*	0.42
SKCM	chr1	205718321	Missense_Mutation	novel	D231N	0.25
SKCM	chr1	205718330	Nonsense_Mutation	NA	K228*	0.23
SKCM	chr1	205718297	Missense_Mutation	NA	P239S	0.33
SKCM	chr1	205718298	Silent	novel	A238A	0.32
SKCM	chr1	205720624	Nonsense_Mutation	novel	K87*	0.47
SKCM	chr1	205727761	Nonsense_Mutation	NA	R38*	0.56
SKCM	chr1	205727761	Nonsense_Mutation	NA	R38*	0.19
SKCM	chr1	205719581	Missense_Mutation	rs527698728	S160P	0.11
STAD	chr1	205718441	Missense_Mutation	NA	R191C	0.11
STAD	chr1	205718414	Nonsense_Mutation	novel	E200*	0.13
STAD	chr1	205719663	Silent	rs535311662	S132S	0.42
STAD	chr1	205718228	3'UTR	novel		0.54
STAD	chr1	205720615	Missense_Mutation	NA	R90C	0.12
STAD	chr1	205718228	3'UTR	novel		0.32
STAD	chr1	205718333	Missense_Mutation	rs764048321	E227K	0.26
UCEC	chr1	205719558	Missense_Mutation	NA	K167N	0.32
UCEC	chr1	205717908	3'UTR	novel		0.2
UCEC	chr1	205720540	Missense_Mutation	novel	E115K	0.41
UCEC	chr1	205718205	3'UTR	novel		0.29
UCEC	chr1	205718434	Missense_Mutation	novel	T193I	0.28
UCEC	chr1	205718358	Silent	NA	K218K	0.17
UCEC	chr1	205750023	5'UTR	novel		0.71
UCEC	chr1	205718440	Missense_Mutation	rs551812416	R191H	0.18
UCEC	chr1	205718367	Silent	rs116436694	P215P	0.23
UCEC	chr1	205719582	Nonsense_Mutation	novel	*K159Nfs2**	0.11
UCEC	chr1	205729621	Missense_Mutation	NA	R6S	0.41
UCEC	chr1	205718228	3'UTR	novel		0.26
UCEC	chr1	205719613	Missense_Mutation	rs758268939	S149L	0.21
UCEC	chr1	205718036	3'UTR	novel		0.3
UCEC	chr1	205727775	Missense_Mutation	NA	P33L	0.41
UCEC	chr1	205718257	3'UTR	rs781384648		0.17
UCEC	chr1	205718228	3'UTR	novel		0.35
UCEC	chr1	205718205	3'UTR	novel		0.43
UCEC	chr1	205718281	Nonstop_Mutation	novel	244Sext2	0.32
UCEC	chr1	205717840	3'UTR	novel		0.63
UCEC	chr1	205719563	Nonsense_Mutation	NA	E166*	0.12
UCEC	chr1	205718239	3'UTR	novel		0.18
UCEC	chr1	205727782	Missense_Mutation	novel	G31S	0.17
UCEC	chr1	205718231	3'UTR	novel		0.24
UCEC	chr1	205720588	Missense_Mutation	novel	A99T	0.56
UCEC	chr1	205719594	Frame_Shift_Ins	novel	*M156Dfs3**	0.17

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.0882	0.033566
DLBC	DEL	0.0625	0.0017831
KIRC	AMP	0.0852	0.059566
READ	AMP	0.2727	0.14328
TGCT	AMP	0.3467	0.088103
TGCT	DEL	0.0133	0.16985
THCA	AMP	0.0481	0.075436

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00031	Kaplan-Meier Survival Analysis
STAD	0.04	Kaplan-Meier Survival Analysis
SARC	0.039	Kaplan-Meier Survival Analysis
MESO	0.004	Kaplan-Meier Survival Analysis
ACC	0.047	Kaplan-Meier Survival Analysis
UCS	0.0038	Kaplan-Meier Survival Analysis
SKCM	0.038	Kaplan-Meier Survival Analysis
KIRP	0.027	Kaplan-Meier Survival Analysis
PAAD	0.042	Kaplan-Meier Survival Analysis
PCPG	0.028	Kaplan-Meier Survival Analysis
KICH	0.04	Kaplan-Meier Survival Analysis
UCEC	0.011	Kaplan-Meier Survival Analysis
LIHC	0.045	Kaplan-Meier Survival Analysis
LGG	0.0059	Kaplan-Meier Survival Analysis
THCA	0.035	Kaplan-Meier Survival Analysis
OV	0.018	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000069275 (Gene tree)
Gene ID: 64710
Gene Symbol: NUCKS1
Alias: NUCKS
Full Name: nuclear casein kinase and cyclin dependent kinase substrate 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 37,458 bases
Position: chr1:205,712,819-205,750,276
Accession: 29923
RBP type: non-canonical RBP
Summary: This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000464938	NUCKS1-202	228	-	-	- (aa)	-	-
ENST00000367142	NUCKS1-201	6496	XM_005245453	ENSP00000356110	243 (aa)	XP_005245510	Q9H1E3

Gene Model

Click here to download ENSG00000069275's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000069275	Body Mass Index	9.81987297723474E-5	17903300
ENSG00000069275	Glucose	7.62130884025447E-8	17903298
ENSG00000069275	Cystatins	5.23723394277269E-14	17903292
ENSG00000069275	Cystatins	1.4189891538334E-9	17903292
ENSG00000069275	Mental Competency	2.07832604537519E-15	17903295
ENSG00000069275	Prostate-Specific Antigen	5E-13	25434496
ENSG00000069275	Menarche	2E-8	25231870
ENSG00000069275	Parkinson Disease	7E-8	19915575
ENSG00000069275	Electrocardiography	6E-7	24952745
ENSG00000069275	Body Height	2E-7	23449627
ENSG00000069275	Parkinson Disease	6E-12	27182965
ENSG00000069275	Parkinson Disease	3E-6	24842889
ENSG00000069275	Parkinson Disease	2E-16	25064009
ENSG00000069275	dimethylarginine	5E-6	24159190

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000069275	rs1775154	1	205727487	A	QT interval	24952745	[0.27-0.63] unit increase	0.45	EFO_0004682
ENSG00000069275	rs951366	1	205716224	T	Menarche (age at onset)	25231870	[0.02-0.04] unit increase	0.03	EFO_0004703
ENSG00000069275	rs823094	1	205720679	G	Pubertal anthropometrics	23449627	[0.03-0.07] unit decrease	0.05	EFO_0004339
ENSG00000069275	rs188212039	1	205743402	G	Symmetrical dimethylarginine levels	24159190	[1.02-2.56] unit increase	1.792	EFO_0005418
ENSG00000069275	rs823128	1	205744250	A	Parkinson's disease	19915575	[NR]	1.52	EFO_0002508
ENSG00000069275	rs4951258	1	205722188	A	Atrial fibrillation	30061737	[1.02-1.05]	1.04	EFO_0000275
ENSG00000069275	rs4951261	1	205748695	C	Atrial fibrillation	29892015	[1.03-1.06]	1.05	EFO_0000275
ENSG00000069275	rs951366	1	205716224	C	Atrial fibrillation	29892015	[1.03-1.06]	1.05	EFO_0000275
ENSG00000069275	rs951366	1	205716224	T	Free thyroxine concentration	30367059	unit increase (discovery)	0.037	EFO_0005130
ENSG00000069275	rs10900522	1	205714939	?	Lipid traits (pleiotropy) (HIPO component 1)	30289880			EFO_0004574\|EFO_0004530\|EFO_0004611\|EFO_0004612

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000069275's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000069275	NUCKS1	100	92.181	ENSMUSG00000026434	Nucks1	100	90.947	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000724	double-strand break repair via homologous recombination	26323318.	IMP	Process
GO:0000785	chromatin	-	ISS	Component
GO:0000790	nuclear chromatin	26323318.	IDA	Component
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	-	IEA	Function
GO:0001678	cellular glucose homeostasis	-	ISS	Process
GO:0003682	chromatin binding	26323318.	IDA	Function
GO:0003690	double-stranded DNA binding	26323318.	IDA	Function
GO:0003697	single-stranded DNA binding	-	IEA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005634	nucleus	11298763.17604136.25116364.26323318.	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	17604136.	IDA	Component
GO:0006275	regulation of DNA replication	26323318.	IMP	Process
GO:0006325	chromatin organization	-	ISS	Process
GO:0006357	regulation of transcription by RNA polymerase II	-	IC	Process
GO:0008134	transcription factor binding	25116364.	IPI	Function
GO:0019046	release from viral latency	25116364.	IMP	Process
GO:0031297	replication fork processing	26323318.	IDA	Process
GO:0035822	gene conversion	26323318.	NAS	Process
GO:0036297	interstrand cross-link repair	26323318.	IMP	Process
GO:0043923	positive regulation by host of viral transcription	25116364.	IGI	Process
GO:0044829	positive regulation by host of viral genome replication	25116364.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046626	regulation of insulin receptor signaling pathway	-	ISS	Process
GO:0046628	positive regulation of insulin receptor signaling pathway	-	IEA	Process
GO:0060382	regulation of DNA strand elongation	26323318.	IMP	Process
GO:0071481	cellular response to X-ray	26323318.	IMP	Process
GO:1990968	modulation by host of RNA binding by virus	25116364.	IMP	Process
GO:1990969	modulation by host of viral RNA-binding transcription factor activity	25116364.	IGI	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.