EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19308738Altered iron metabolism, inflammation, transferrin receptors, and ferritin expression in non-small-cell lung cancer.Med Oncol2010 JunKukulj Sdoi: 10.1007/s12032-009-9203-2
19066835Transferrin-receptor-mediated iron accumulation controls proliferation and glutamate release in glioma cells.J Mol Med (Berl)2009 FebChirasani SRdoi: 10.1007/s00109-008-0414-3
20071291Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors.J Chemother2009 DecZhu X-
12163483Shedding of the transferrin receptor is mediated constitutively by an integral membrane metalloprotease sensitive to tumor necrosis factor alpha protease inhibitor-2.J Biol Chem2002 Oct 11Kaup M-
26657500MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis.Oncotarget2016 Jan 12Kindrat Idoi: 10.18632/oncotarget.6004.
21523522Absence of CD71 transferrin receptor characterizes human gastric adenosquamous carcinoma stem cells.Ann Surg Oncol2012 AprOhkuma Mdoi: 10.1245/s10434-011-1739-7
26869514Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation.Biochem Biophys Res Commun2016 Mar 11Jeong SMdoi: 10.1016/j.bbrc.2016.02.023
21859709Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival.J Biol Chem2011 Oct 14Jian Jdoi: 10.1074/jbc.M111.271585
16092918Inhibition of transferrin receptor 1 transcription by a cell density response element.Biochem J2005 Dec 1Wang J-
19238537Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen.Breast Cancer Res Treat2010 JanHabashy HOdoi: 10.1007/s10549-009-0345-x
27523281EGFR regulates iron homeostasis to promote cancer growth through redistribution of transferrin receptor 1.Cancer Lett2016 Oct 28Wang Bdoi: 10.1016/j.canlet.2016.08.006
27384479Desferal regulates hCtr1 and transferrin receptor expression through Sp1 and exhibits synergistic cytotoxicity with platinum drugs in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo.Oncotarget2016 Aug 2Chen SJdoi: 10.18632/oncotarget.10336.
30056091Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle.Nanomedicine2018 OctDu Ydoi: 10.1016/j.nano.2018.07.007

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr3196064346SilentnovelL427L0.17
BLCAchr3196067651Missense_MutationnovelL303M0.37
BLCAchr3196052094Missense_MutationnovelA711T0.16
BLCAchr3196072100Missense_MutationnovelE163K0.38
BLCAchr3196068052Missense_MutationNAE294K0.17
BLCAchr3196058283Splice_SitenovelX559_splice0.17
BLCAchr3196069570Splice_Regionnovel0.19
BLCAchr3196052113Silentrs146993606S704S0.19
BLCAchr3196072079Missense_MutationnovelE170K0.14
BLCAchr3196075235Silentrs41300443A54A0.32
BLCAchr3196067608Missense_MutationnovelN317S0.18
BLCAchr3196053522Missense_MutationNAR646C0.52
BLCAchr31960771035'UTRnovel0.32
BLCAchr3196064354Missense_MutationnovelL425V0.32
BLCAchr3196055158SilentnovelL607L0.18
BLCAchr3196075199Silentrs761390479I66I0.5
BRCAchr3196075252Missense_MutationNAD49Y0.25
BRCAchr31960517533'UTRnovel0.09
BRCAchr3196065573Missense_MutationnovelD356E0.12
BRCAchr3196075328SilentNAF23F0.23
BRCAchr31960513683'UTRnovel0.16
BRCAchr3196060205Missense_Mutationrs769366579T504M0.25
CESCchr3196053532Silentrs749863139L642L0.27
CESCchr3196073969Missense_Mutationrs370784605S132L0.16
CESCchr3196051976Missense_MutationnovelS750F0.37
CESCchr3196072140SilentNAE149E0.12
CESCchr31960511813'UTRnovel0.21
CESCchr31960518263'UTRnovel0.36
CESCchr31960505193'UTRnovel0.16
CESCchr3196053428Missense_Mutationrs41298067R677H0.27
CESCchr3196074041Missense_MutationnovelV108A0.4
CESCchr3196052070Missense_Mutationrs764730449R719C0.15
CHOLchr3196062928Missense_MutationnovelP444T0.12
COADchr3196051968Missense_Mutationrs141165322V753I0.41
COADchr3196052133Nonsense_Mutationrs373764388R698*0.14
COADchr3196069518SilentnovelL246L0.13
COADchr3196072055Missense_MutationNAL178F0.3
COADchr3196075168Missense_MutationNAF77V0.31
COADchr3196053521Missense_MutationNAR646H0.23
COADchr3196055199Missense_Mutationrs768871682A594T0.38
COADchr31960517343'UTRnovel0.31
COADchr3196058299SilentnovelS554S0.08
COADchr3196074051Missense_Mutationrs773087880E105K0.22
COADchr3196072116SilentNAA157A0.3
COADchr3196052010Missense_MutationnovelT739A0.08
COADchr3196074002Missense_Mutationrs772641140R121H0.27
COADchr3196052038Silentrs776066581T729T0.41
ESCAchr3196052070Missense_Mutationrs764730449R719C0.14
ESCAchr3196064408Missense_MutationNAA407S0.12
ESCAchr31960509513'UTRnovel0.47
GBMchr3196052006Missense_MutationnovelW740L0.18
GBMchr3196062586SilentnovelV488V0.05
GBMchr3196075232Missense_MutationnovelN55K0.05
HNSCchr3196055205Missense_MutationnovelE592K0.18
HNSCchr3196053549Missense_MutationnovelL637M0.56
HNSCchr3196058333Missense_MutationnovelP543H0.24
HNSCchr3196069533Frame_Shift_DelnovelD242Ifs*90.42
HNSCchr3196072017SilentnovelI190I0.07
HNSCchr3196062879Missense_Mutationrs781649382S460L0.31
HNSCchr3196072132Missense_MutationnovelY152C0.12
HNSCchr3196072115Nonsense_MutationnovelG158*0.22
HNSCchr3196055251SilentnovelL576L0.12
HNSCchr3196065588Silentrs532098606G351G0.09
KIRCchr3196068069Nonsense_MutationnovelK287_F288ins*0.69
KIRCchr3196071473Missense_MutationnovelD204Y0.03
KIRCchr3196051948Missense_MutationNAE759D0.3
KIRPchr3196074118Frame_Shift_InsnovelM82Ifs*20.29
KIRPchr3196055294Missense_MutationNAD562V0.45
KIRPchr3196055295Missense_MutationnovelD562H0.45
LAMLchr3196062934Missense_MutationnovelF442L0.11
LGGchr3196074116Missense_MutationNAI83T0.2
LGGchr31960518923'UTRnovel0.06
LGGchr3196077073Missense_MutationNAF9L0.28
LIHCchr3196060191Missense_MutationnovelT509A0.08
LIHCchr3196075345SilentnovelL18L0.1
LIHCchr3196058590Missense_MutationNAN527Y0.09
LUADchr3196067545Missense_Mutationrs776805794S338C0.2
LUADchr3196072049Missense_MutationnovelK180E0.2
LUADchr3196074002Missense_MutationnovelR121L0.13
LUADchr3196071465Silentrs769020607N206N0.14
LUADchr3196071451Missense_MutationNAY211S0.26
LUADchr3196052174Missense_MutationnovelH684L0.12
LUSCchr3196062924Missense_MutationnovelS445I0.15
LUSCchr3196067554Missense_MutationnovelQ335R0.19
LUSCchr3196074002Missense_Mutationrs772641140R121H0.61
LUSCchr3196052012Missense_MutationnovelA738G0.07
LUSCchr31960518183'UTRnovel0.2
LUSCchr3196052060Missense_MutationnovelN722S0.18
OVchr3196072123Missense_Mutationrs775554571R155H0.29
OVchr3196055284Nonsense_MutationNAY565*0.15
OVchr3196052028Frame_Shift_InsnovelN733Afs*60.15
OVchr3196075291Missense_MutationnovelV36M0.17
OVchr3196052158Silentrs199652297Y689Y0.26
OVchr3196053485Missense_MutationNAT658R0.51
OVchr3196067595In_Frame_InsnovelF321delinsLEYVALILIC0.05
OVchr3196075273Missense_MutationnovelV42I0.06
OVchr3196058615SilentNAT518T0.1
OVchr3196055081Missense_MutationnovelK633R0.05
PRADchr3196073968Silentrs150889988S132S0.39
PRADchr3196069452Splice_Regionnovel0.14
PRADchr3196055287SilentnovelP564P0.17
PRADchr3196069532Missense_MutationnovelD242Y0.52
READchr3196072067Missense_Mutationrs746712619R174C0.29
SARCchr31960518463'UTRnovel0.29
SARCchr3196058612SilentnovelG519G0.39
SKCMchr3196072141Missense_Mutationrs765076763E149G0.24
SKCMchr31960518663'UTRrs7467362980.29
SKCMchr3196072038SilentnovelR183R0.25
SKCMchr3196064370Silentrs142218775S419S0.25
SKCMchr3196064371Missense_MutationnovelS419F0.25
SKCMchr3196072067Missense_Mutationrs746712619R174C0.43
SKCMchr3196067613SilentNAS315S0.36
SKCMchr3196071468SilentNAK205K0.38
SKCMchr3196052141Missense_MutationNAS695F0.37
SKCMchr3196067635Missense_MutationNAP308L0.35
SKCMchr3196067545Missense_MutationnovelS338F0.13
SKCMchr3196055162Missense_MutationNAE606G0.88
STADchr3196065540SilentnovelT367T0.16
STADchr3196062914SilentNAI448I0.13
STADchr3196065528SilentnovelK371K0.36
STADchr3196060204Silentrs747811597T504T0.33
STADchr3196073989SilentNAD125D0.29
STADchr3196071465Silentrs769020607N206N0.32
STADchr31960771185'UTRnovel0.08
TGCTchr3196062923Missense_MutationnovelS445R0.08
UCECchr3196052069Missense_Mutationrs200232625R719H0.14
UCECchr31960515883'UTRnovel0.21
UCECchr3196071497Missense_Mutationrs780997842A196T0.33
UCECchr3196071426SilentnovelY219Y0.33
UCECchr3196071421Missense_Mutationrs754768415A221V0.33
UCECchr3196055208Missense_MutationnovelA591T0.52
UCECchr31960514493'UTRrs7507117830.53
UCECchr3196067626Missense_MutationNAP311H0.4
UCECchr3196060205Missense_Mutationrs769366579T504M0.42
UCECchr3196072129Missense_MutationnovelV153A0.36
UCECchr3196051969SilentNAD752D0.17
UCECchr3196073936Missense_Mutationrs765116281T143I0.2
UCECchr31960513043'UTRnovel0.47
UCECchr31960510013'UTRnovel0.29
UCECchr3196060220Missense_MutationnovelS499N0.35
UCECchr3196075318Missense_MutationnovelR27W0.39
UCECchr3196062917SilentNAS447S0.19
UCECchr31960512293'UTRnovel0.57
UCECchr31960517343'UTRnovel0.36
UCECchr3196052070Missense_Mutationrs764730449R719C0.5
UCECchr31960518793'UTRrs7531213870.3
UCECchr3196065485Missense_Mutationrs745399746I386V0.47
UCECchr3196072067Missense_Mutationrs746712619R174C0.49
UCECchr3196067532SilentnovelA342A0.34
UCECchr3196058633Splice_SitenovelX513_splice0.15
UCECchr3196064389Missense_MutationnovelG413D0.24
UCECchr31960509523'UTRnovel0.42
UCECchr31960518113'UTRnovel0.32
UCECchr31960519063'UTRnovel0.43
UCECchr3196060215Missense_MutationnovelL501V0.12
UCECchr31960507073'UTRnovel0.53
UCECchr3196074093Missense_MutationnovelG91W0.24
UCECchr31960512293'UTRnovel0.3
UCECchr31960509513'UTRnovel0.38
UCECchr3196052098SilentnovelL709L0.4
UCECchr3196064385SilentnovelP414P0.33
UCECchr31960504443'UTRnovel0.11
UCECchr31960506853'UTRnovel0.26
UCECchr3196062879Missense_Mutationrs781649382S460L0.31
UCECchr3196072067Missense_Mutationrs746712619R174C0.33
UCECchr3196065519SilentnovelK374K0.37
UCECchr31960503663'UTRnovel0.38
UCECchr31960510183'UTRnovel0.43
UCECchr3196065466Missense_MutationNAV392A0.32
UCECchr3196074002Missense_Mutationrs772641140R121H0.06
UCECchr3196052157Missense_Mutationrs577771580V690I0.32
UCECchr3196055088Missense_MutationnovelD631Y0.34
UCECchr3196060204Silentrs747811597T504T0.12
UCECchr3196058306Missense_MutationnovelA552V0.38
UCECchr3196075336Missense_MutationnovelT21A0.3
UCECchr3196055243Missense_MutationnovelR579K0.06
UCECchr3196058322Missense_MutationnovelY547H0.08
UCECchr3196052070Missense_MutationnovelR719S0.21
UCECchr3196052157Missense_Mutationrs577771580V690I0.35
UCECchr31960518783'UTRrs1423968030.4
UCECchr31960512693'UTRnovel0.34
UCECchr3196058588SilentnovelN527N0.32
UCECchr3196069510Missense_MutationnovelP249H0.28

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.43380.0018563
DLBCAMP0.29170.0048479
GBMDEL0.08673.2518e-06
KIRCAMP0.11932.0306e-05
KIRPAMP0.31940.15981
LGGDEL0.08384.7283e-05
LUADDEL0.1880.010111
PAADAMP0.11410.16151
PRADDEL0.05690.17738
SARCDEL0.17120.0086757

Survival Analysis
CancerP-value Q-value
STAD0.025

Kaplan-Meier Survival Analysis

SARC0.014

Kaplan-Meier Survival Analysis

MESO0.046

Kaplan-Meier Survival Analysis

ACC0.002

Kaplan-Meier Survival Analysis

HNSC0.044

Kaplan-Meier Survival Analysis

LUSC0.018

Kaplan-Meier Survival Analysis

BRCA0.035

Kaplan-Meier Survival Analysis

TGCT0.02

Kaplan-Meier Survival Analysis

KIRP0.00045

Kaplan-Meier Survival Analysis

PAAD0.00094

Kaplan-Meier Survival Analysis

BLCA0.028

Kaplan-Meier Survival Analysis

CESC0.0013

Kaplan-Meier Survival Analysis

READ0.033

Kaplan-Meier Survival Analysis

LAML0.049

Kaplan-Meier Survival Analysis

KICH0.0087

Kaplan-Meier Survival Analysis

LIHC0.00077

Kaplan-Meier Survival Analysis

THCA0.0011

Kaplan-Meier Survival Analysis

LUAD0.028

Kaplan-Meier Survival Analysis

UVM0.017

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000072274 (Gene tree)
Gene ID
7037
Gene Symbol
TFRC
Alias
CD71|TFR1|p90
Full Name
transferrin receptor
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
55,007 bases
Position
chr3:196,027,183-196,082,189
Accession
11763
RBP type
non-canonical RBP
Summary
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
1281544Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding.Proc Natl Acad Sci U S A1992 Dec 15Haile DJ-
7556182Nitric-oxide-mediated activation of iron-regulatory protein controls hepatic iron metabolism during acute inflammation.Eur J Biochem1995 Sep 1Cairo G-
8764614Demonstration and characterization of the iron regulatory protein in human brain.J Neurochem1996 AugHu J-
1738601Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation.Nucleic Acids Res1992 Jan 11Hirling H-
9371267New advances in iron metabolism, iron deficiency, and iron overload.Curr Opin Hematol1994 MarBrittenham GM-
8514748Interleukin-2-dependent transcriptional and post-transcriptional regulation of transferrin receptor mRNA.J Biol Chem1993 Jun 25Seiser C-
8262977Iron-responsive element-binding protein. Phosphorylation by protein kinase C.J Biol Chem1993 Dec 25Eisenstein RS-
10329709Ligand-induced structural alterations in human iron regulatory protein-1 revealed by protein footprinting.J Biol Chem1999 May 21Gegout V-
10582343Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation.Int J Biochem Cell Biol1999 OctThomson AM-
25289190Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5.PeerJ2014 Sep 30Peterson JMdoi: 10.7717/peerj.605
7493976Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA.J Biol Chem1995 Dec 8Seiser C-
10429185The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake.Eur J Biochem1999 JulWardrop SL-
8636154Phosphorylation and activation of both iron regulatory proteins 1 and 2 in HL-60 cells.J Biol Chem1996 Mar 22Schalinske KL-
8233829A novel transforming growth factor-beta 1 responsive cytoplasmic trans-acting factor binds selectively to the 3'-untranslated region of mammalian ribonucleotide reductase R2 mRNA: role in message stability.Nucleic Acids Res1993 Oct 11Amara FM-
7579417The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells.Blood1995 Oct 15Richardson DR-
11969379Role of hypolipidemic drug clofibrate in altering iron regulatory proteins IRP1 and IRP2 activities and hepatic iron metabolism in rats fed a low-iron diet.Toxicol Appl Pharmacol2002 Apr 15Huang HL-
11054110Interferon-gamma and lipopolysaccharide regulate the expression of Nramp2 and increase the uptake of iron from low relative molecular mass complexes by macrophages.Eur J Biochem2000 NovWardrop SL-
15883202Molecular pharmacology of the interaction of anthracyclines with iron.Mol Pharmacol2005 AugXu X-
15522954Overexpression of mitochondrial ferritin causes cytosolic iron depletion and changes cellular iron homeostasis.Blood2005 Mar 1Nie G-
15178542Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta.Am J Physiol Regul Integr Comp Physiol2004 OctBradley J-
16757684In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin.Blood2006 Oct 1Nie G-
19501056Ovariectomy and estrogen treatment modulate iron metabolism in rat adipose tissue.Biochem Pharmacol2009 Oct 15Mattace Raso Gdoi: 10.1016/j.bcp.2009.05.034
19223469Cysteine oxidation regulates the RNA-binding activity of iron regulatory protein 2.Mol Cell Biol2009 AprZumbrennen KBdoi: 10.1128/MCB.00004-09
18029484Retinoic acid modulates hepatic iron homeostasis in rats by attenuating the RNA-binding activity of iron regulatory proteins.J Nutr2007 DecSchroeder SE-
1537839Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells.J Biol Chem1992 Mar 5Wedrychowski A-
12682639Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies.Leukemia2003 AprLossos IS-
1421965An iron-sulfur cluster plays a novel regulatory role in the iron-responsive element binding protein.Biometals1992 AutumnRouault TA-
8702520Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element.J Biol Chem1996 Aug 2Warriar N-
9862796Oxidation of guanines in the iron-responsive element RNA: similar structures from chemical modification and recent NMR studies.Chem Biol1998 DecCiftan SA-
2050125Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA.EMBO J1991 JulCox TC-
8485201The transferrin receptor.Crit Rev Oncog1993Testa U-
8490018Posttranscriptional regulation of chimeric human transferrin genes by iron.Biochemistry1993 May 11Cox LA-
8290565The iron-responsive element-binding protein: localization of the RNA-binding site to the aconitase active-site cleft.Proc Natl Acad Sci U S A1994 Jan 18Basilion JP-
7666462Reversal by transferrin of growth-inhibitory effect of suramin on hormone-refractory human prostate cancer cells.J Natl Cancer Inst1995 Jan 4Donat SM-
16545456Molecular mechanism of distorted iron regulation in the blood-CSF barrier and regional blood-brain barrier following in vivo subchronic manganese exposure.Neurotoxicology2006 SepLi GJ-
12864947[Effect of T3 on the expression of transferrin receptor and ferritin in K562 cells and its possible mechanism].Zhonghua Xue Ye Xue Za Zhi2003 AprZhou M-
15880423Flow cytometric analysis of micronucleated reticulocytes: Time- and dose-dependent response of known mutagens in mice, using multiple blood sampling.Environ Mol Mutagen2005 JulDe Boeck M-
15543203Normalization of gene expression measurements in tumor tissues: comparison of 13 endogenous control genes.Lab Invest2005 Jande Kok JB-
26797126Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.J Biol Chem2016 Mar 25Okazaki Fdoi: 10.1074/jbc.M115.713412
28754683DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism.Blood2017 Sep 21Ovchynnikova Edoi: 10.1182/blood-2017-03-774364
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000465288TFRC-210560--- (aa)--
ENST00000426789TFRC-205354-ENSP00000414015118 (aa)-H7C3V5
ENST00000360110TFRC-2015111XM_024453731ENSP00000353224760 (aa)XP_024309499P02786
ENST00000463356TFRC-207533--- (aa)--
ENST00000392396TFRC-2025032-ENSP00000376197760 (aa)-P02786
ENST00000491658TFRC-215396--- (aa)--
ENST00000464011TFRC-208546--- (aa)--
ENST00000463047TFRC-206549--- (aa)--
ENST00000420415TFRC-2034814-ENSP00000390133679 (aa)-G3V0E5
ENST00000477148TFRC-212570--- (aa)--
ENST00000421258TFRC-204524-ENSP0000040283981 (aa)-F8WBE5
ENST00000464368TFRC-209569--- (aa)--
ENST00000483983TFRC-214757--- (aa)--
ENST00000482479TFRC-213540--- (aa)--
ENST00000475593TFRC-211875--- (aa)--
Gene Model
Click here to download ENSG00000072274's gene model file
Pathways
Pathway IDPathway NameSource
hsa04066HIF-1 signaling pathwayKEGG
hsa04144EndocytosisKEGG
hsa04145PhagosomeKEGG
hsa04216FerroptosisKEGG
hsa04640Hematopoietic cell lineageKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000072274Erythrocyte Indices8E-1319862010
ENSG00000072274Erythrocyte Indices5E-1328017375
ENSG00000072274Erythrocyte Count1E-1228017375
ENSG00000072274Erythrocyte Count8E-1419862010
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000072274rs1136351363196075973CAHigh light scatter reticulocyte percentage of red cells27863252[0.025-0.041] unit decrease0.03297408EFO_0007986
ENSG00000072274rs37891353196065999AMean corpuscular hemoglobin27863252[0.063-0.077] unit increase0.07033563EFO_0004527
ENSG00000072274rs556492263196076467CMean corpuscular volume27863252[0.06-0.074] unit increase0.06682039EFO_0004526
ENSG00000072274rs98592603196073676?Mean corpuscular volume28017375EFO_0004526
ENSG00000072274rs98592603196073676CMean corpuscular volume19862010[0.002-0.004] fl increase0EFO_0004526
ENSG00000072274rs49278583196045068?Mean corpuscular volume29403010[0.039-0.059] unit increase novel0.04922EFO_0004526
ENSG00000072274rs67917633196031033?Mean corpuscular hemoglobin29403010[0.062-0.086] unit increase novel0.07408EFO_0004527
ENSG00000072274rs38041393196080754?Mean corpuscular hemoglobin concentration29403010[0.032-0.052] unit increase novel0.04165EFO_0004528
ENSG00000072274rs1136351363196075973CAReticulocyte fraction of red cells27863252[0.023-0.04] unit decrease0.03151933EFO_0007986
ENSG00000072274rs98592603196073676CMean corpuscular volume28453575[0.002-0.006] unit decrease0.004EFO_0004526
ENSG00000072274rs1136351363196075973CARed cell distribution width28957414[0.06-0.078] unit increase0.0688588EFO_0005192
ENSG00000072274rs117155243196035621?Respiratory diseases30595370EFO_0000684
ENSG00000072274rs413004353196077150?Red cell distribution width30595370EFO_0005192
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000072274's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000072274TFRC9982.500ENSMUSG00000022797Tfrc10076.832Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0001558regulation of cell growth7556058.IMPProcess
GO:0001618virus receptor activity-IEAFunction
GO:0003723RNA binding22658674.HDAFunction
GO:0003725double-stranded RNA binding21266579.IDAFunction
GO:0004998transferrin receptor activity18353247.ICFunction
GO:0004998transferrin receptor activity26642240.IDAFunction
GO:0004998transferrin receptor activity1871153.NASFunction
GO:0005515protein binding9465039.9546397.9990067.10638746.14691533.15965644.16271884.16325581.16354665.18353247.20133674.20404192.20618438.21788477.23384347.25416956.26642240.29302006.IPIFunction
GO:0005576extracellular region1871153.IDAComponent
GO:0005615extracellular space22664934.HDAComponent
GO:0005768endosome14612438.IDAComponent
GO:0005769early endosome-IEAComponent
GO:0005886plasma membrane-TASComponent
GO:0005887integral component of plasma membrane18353247.IGIComponent
GO:0005905clathrin-coated pit12857860.IDAComponent
GO:0006826iron ion transport7556058.IDAProcess
GO:0006879cellular iron ion homeostasis1871153.NASProcess
GO:0009897external side of plasma membrane18353247.IGIComponent
GO:0009986cell surface7556058.IDAComponent
GO:0010008endosome membrane16380373.IDAComponent
GO:0010008endosome membrane-TASComponent
GO:0016020membrane1871153.NASComponent
GO:0016323basolateral plasma membrane9990067.IDAComponent
GO:0030316osteoclast differentiation-IEAProcess
GO:0030665clathrin-coated vesicle membrane-TASComponent
GO:0030890positive regulation of B cell proliferation26642240.IDAProcess
GO:0031410cytoplasmic vesicle15229288.IDAComponent
GO:0031623receptor internalization26642240.IDAProcess
GO:0033570transferrin transmembrane transporter activity-IEAFunction
GO:0033572transferrin transport18353247.ICProcess
GO:0033572transferrin transport26642240.IDAProcess
GO:0033572transferrin transport-TASProcess
GO:0035690cellular response to drug16254249.IDAProcess
GO:0042102positive regulation of T cell proliferation26642240.IDAProcess
GO:0042127regulation of cell proliferation7556058.IMPProcess
GO:0042470melanosome-IEAComponent
GO:0042802identical protein binding20208545.23384347.29302006.IPIFunction
GO:0042803protein homodimerization activity9546397.IPIFunction
GO:0045780positive regulation of bone resorption-IEAProcess
GO:0045830positive regulation of isotype switching26642240.IDAProcess
GO:0046718viral entry into host cell-IEAProcess
GO:0048471perinuclear region of cytoplasm16380373.20202662.IDAComponent
GO:0055037recycling endosome22456507.24561039.IDAComponent
GO:0061024membrane organization-TASProcess
GO:0070062extracellular exosome20458337.HDAComponent
GO:0072562blood microparticle22516433.HDAComponent
GO:1903561extracellular vesicle24769233.HDAComponent
GO:1990712HFE-transferrin receptor complex9465039.9546397.9990067.IDAComponent
GO:1990830cellular response to leukemia inhibitory factor-IEAProcess
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