EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	35136453	Silent	NA	N291N	0.2
BLCA	chr17	35142003	Silent	novel	L46L	0.33
BLCA	chr17	35133450	Silent	rs145494138	A421A	0.29
BLCA	chr17	35137859	Missense_Mutation	novel	W164C	0.05
BRCA	chr17	35136211	Silent	NA	Q323Q	0.27
BRCA	chr17	35136407	Missense_Mutation	NA	E307Q	0.38
CESC	chr17	35142066	Silent	novel	G25G	0.1
CESC	chr17	35132394	3'UTR	novel		0.22
CESC	chr17	35130621	3'Flank	novel		0.37
CESC	chr17	35140033	Missense_Mutation	rs144542845	D66N	0.23
COAD	chr17	35133449	Missense_Mutation	novel	W422G	0.32
COAD	chr17	35135309	Missense_Mutation	rs200560049	R385H	0.24
COAD	chr17	35139873	Missense_Mutation	NA	S119Y	0.36
COAD	chr17	35132311	3'UTR	novel		0.24
COAD	chr17	35133423	Silent	NA	V430V	0.23
COAD	chr17	35137100	Silent	rs757052556	T243T	0.23
COAD	chr17	35133450	Silent	rs145494138	A421A	0.29
COAD	chr17	35136170	Missense_Mutation	rs201219885	R337Q	0.35
COAD	chr17	35136421	Missense_Mutation	NA	R302H	0.36
COAD	chr17	35135251	Splice_Region	NA	G404G	0.1
COAD	chr17	35142230	Intron	novel		0.17
COAD	chr17	35142230	Intron	novel		0.18
COAD	chr17	35132347	3'UTR	novel		0.4
COAD	chr17	35137111	Missense_Mutation	rs372790802	R240C	0.38
COAD	chr17	35141998	Missense_Mutation	novel	C48Y	0.31
COAD	chr17	35137058	Missense_Mutation	NA	D257E	0.3
COAD	chr17	35133480	Silent	rs147757651	R411R	0.24
ESCA	chr17	35135261	Missense_Mutation	novel	G401V	0.1
ESCA	chr17	35137144	Missense_Mutation	rs748512588	R229W	0.3
HNSC	chr17	35142059	Silent	novel	L28L	0.21
KIRC	chr17	35137002	Missense_Mutation	NA	D276A	0.08
KIRC	chr17	35133368	Missense_Mutation	novel	A449T	0.19
LGG	chr17	35137128	Missense_Mutation	novel	T234N	0.17
LGG	chr17	35137129	Missense_Mutation	novel	T234S	0.17
LGG	chr17	35137144	Missense_Mutation	rs748512588	R229W	0.37
LIHC	chr17	35140014	Missense_Mutation	NA	S72L	0.33
LIHC	chr17	35135266	Missense_Mutation	NA	W399C	0.51
LIHC	chr17	35132340	3'UTR	novel		0.53
LIHC	chr17	35142072	Silent	novel	D23D	0.3
LUAD	chr17	35136174	Missense_Mutation	novel	V336L	0.1
LUAD	chr17	35137144	Silent	novel	R229R	0.46
LUAD	chr17	35137145	Silent	novel	V228V	0.46
LUAD	chr17	35137637	Missense_Mutation	novel	L181V	0.2
LUAD	chr17	35140028	Silent	NA	A67A	0.24
LUAD	chr17	35136421	Missense_Mutation	NA	R302H	0.21
LUAD	chr17	35142074	Missense_Mutation	NA	D23Y	0.28
LUAD	chr17	35135452	Splice_Site	NA	X338_splice	0.21
LUSC	chr17	35136199	Silent	NA	E327E	0.05
LUSC	chr17	35137049	Silent	NA	L260L	0.17
OV	chr17	35133447	Missense_Mutation	NA	W422C	0.21
OV	chr17	35140062	Missense_Mutation	novel	D56G	0.52
OV	chr17	35139959	Missense_Mutation	novel	I90M	0.11
OV	chr17	35139237	Missense_Mutation	novel	K153R	0.14
PAAD	chr17	35136174	Missense_Mutation	rs187705654	V336M	0.17
PAAD	chr17	35140008	Missense_Mutation	novel	G74V	0.17
PRAD	chr17	35135257	Silent	NA	R402R	0.11
READ	chr17	35139875	Missense_Mutation	novel	I118M	0.33
SKCM	chr17	35140022	Silent	rs775982751	I69I	0.39
SKCM	chr17	35137635	Silent	NA	L181L	0.24
SKCM	chr17	35137001	Missense_Mutation	novel	D276E	0.38
SKCM	chr17	35139902	Silent	NA	S109S	0.29
SKCM	chr17	35137120	Missense_Mutation	rs539954745	R237C	0.49
SKCM	chr17	35139929	Silent	rs764015442	V100V	0.3
SKCM	chr17	35142051	Silent	NA	G30G	0.3
SKCM	chr17	35137038	Missense_Mutation	NA	S264F	0.16
SKCM	chr17	35135293	Silent	rs771292661	A390A	0.69
SKCM	chr17	35135294	Missense_Mutation	novel	A390V	0.7
STAD	chr17	35137113	Missense_Mutation	NA	E239V	0.12
STAD	chr17	35137001	Splice_Region	rs139216593	D276D	0.29
STAD	chr17	35133465	Silent	rs148833526	A416A	0.48
STAD	chr17	35136468	Silent	novel	H286H	0.06
STAD	chr17	35133474	Silent	rs369573413	H413H	0.18
STAD	chr17	35137016	Silent	NA	V271V	0.09
STAD	chr17	35137029	Missense_Mutation	rs745418741	R267H	0.16
STAD	chr17	35133346	Missense_Mutation	rs767590380	A456V	0.2
STAD	chr17	35137178	Silent	novel	R217R	0.32
UCEC	chr17	35132399	3'UTR	rs201965669		0.51
UCEC	chr17	35133192	Missense_Mutation	novel	G475E	0.4
UCEC	chr17	35136363	Splice_Region	novel	S321S	0.39
UCEC	chr17	35133178	Missense_Mutation	novel	L480I	0.04
UCEC	chr17	35137870	Missense_Mutation	NA	S161G	0.31
UCEC	chr17	35139253	Missense_Mutation	novel	P148S	0.61
UCEC	chr17	35130532	3'Flank	rs545725794		0.45
UCEC	chr17	35130690	3'Flank	novel		0.23
UCEC	chr17	35139941	Silent	NA	A96A	0.17
UCEC	chr17	35137582	Missense_Mutation	NA	S199I	0.28
UCEC	chr17	35137616	Missense_Mutation	novel	G188W	0.15
UCEC	chr17	35132306	3'UTR	novel		0.4
UCEC	chr17	35136175	Silent	rs761450998	L335L	0.41
UCEC	chr17	35137823	Silent	novel	K176K	0.34
UCEC	chr17	35130603	3'Flank	novel		0.11
UCEC	chr17	35136466	Missense_Mutation	novel	G287D	0.4
UCEC	chr17	35142076	Missense_Mutation	novel	Q22R	0.6
UCEC	chr17	35135374	Silent	NA	K363K	0.42
UCEC	chr17	35130527	3'Flank	novel		0.4
UCEC	chr17	35136175	Silent	rs761450998	L335L	0.54
UCEC	chr17	35137863	Missense_Mutation	novel	S163Y	0.18
UCEC	chr17	35130713	3'Flank	novel		0.18
UCEC	chr17	35139287	Silent	NA	T136T	0.46
UCEC	chr17	35142082	Missense_Mutation	novel	Q20R	0.18
UCEC	chr17	35142167	Intron	novel		0.24
UCEC	chr17	35133375	Silent	novel	Q446Q	0.37
UCEC	chr17	35137000	Splice_Site	novel	X276_splice	0.43
UCEC	chr17	35137874	Silent	novel	V159V	0.39
UCEC	chr17	35140025	Missense_Mutation	novel	E68D	0.51
UCEC	chr17	35136186	Nonsense_Mutation	rs753158734	R332*	0.38
UCEC	chr17	35136441	Silent	NA	L295L	0.39
UCEC	chr17	35137144	Missense_Mutation	rs748512588	R229W	0.44
UCEC	chr17	35142019	Frame_Shift_Del	novel	*P41Rfs48**	0.43
UCEC	chr17	35132432	3'UTR	novel		0.27
UCEC	chr17	35140033	Missense_Mutation	novel	D66Y	0.16
UCEC	chr17	35133433	Missense_Mutation	rs766331515	R427Q	0.48
UCEC	chr17	35137057	Missense_Mutation	rs368988690	G258R	0.12
UCEC	chr17	35140039	Missense_Mutation	novel	V64I	0.26
UCEC	chr17	35135255	Missense_Mutation	rs373970543	T403M	0.58
UCEC	chr17	35140002	Missense_Mutation	rs776328487	T76M	0.44
UCEC	chr17	35136467	Missense_Mutation	rs764633856	G287S	0.14
UCEC	chr17	35133474	Silent	rs369573413	H413H	0.18
UCEC	chr17	35133495	Silent	novel	Y406Y	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0	0.18166
THCA	DEL	0.002	0.221
UCS	DEL	0.3929	0.19877
UVM	DEL	0.025	0.22482

Survival Analysis

Cancer	P-value	Q-value
THYM	0.018	Kaplan-Meier Survival Analysis
KIRC	0.0028	Kaplan-Meier Survival Analysis
SARC	0.00019	Kaplan-Meier Survival Analysis
MESO	0.02	Kaplan-Meier Survival Analysis
ACC	0.0051	Kaplan-Meier Survival Analysis
HNSC	0.033	Kaplan-Meier Survival Analysis
SKCM	0.026	Kaplan-Meier Survival Analysis
PRAD	0.04	Kaplan-Meier Survival Analysis
KIRP	0.019	Kaplan-Meier Survival Analysis
PCPG	0.031	Kaplan-Meier Survival Analysis
BLCA	0.011	Kaplan-Meier Survival Analysis
READ	0.032	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.015	Kaplan-Meier Survival Analysis
UVM	0.0053	Kaplan-Meier Survival Analysis
OV	0.016	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000073536 (Gene tree)
Gene ID: 54475
Gene Symbol: NLE1
Alias: FLJ10458|NLE
Full Name: notchless homolog 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 13,563 bases
Position: chr17:35,128,753-35,142,315
Accession: 19889
RBP type: non-canonical RBP
Summary: (Notchless Homolog 1) is a Protein Coding gene. Diseases associated with NLE1 include Noonan Syndrome 1 and Noonan Syndrome 3.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000360831	NLE1-201	1726	-	ENSP00000354075	443 (aa)	-	A0A0A0MRH0
ENST00000588642	NLE1-205	580	-	ENSP00000465420	87 (aa)	-	K7EK23
ENST00000586869	NLE1-203	5286	XM_017024777	ENSP00000466588	193 (aa)	XP_016880266	Q9NVX2
ENST00000588019	NLE1-204	1107	-	ENSP00000466764	304 (aa)	-	K7EN33
ENST00000442241	NLE1-202	2588	-	ENSP00000413572	485 (aa)	-	Q9NVX2
ENST00000593176	NLE1-207	800	-	-	- (aa)	-	-
ENST00000589367	NLE1-206	1017	-	ENSP00000468339	127 (aa)	-	K7ERN7

Gene Model

Click here to download ENSG00000073536's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000073536's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000027	ribosomal large subunit assembly	21873635.	IBA	Process
GO:0001756	somitogenesis	-	IEA	Process
GO:0001822	kidney development	-	IEA	Process
GO:0001826	inner cell mass cell differentiation	-	IEA	Process
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0007219	Notch signaling pathway	21873635.	IBA	Process
GO:0045930	negative regulation of mitotic cell cycle	-	IEA	Process
GO:0048705	skeletal system morphogenesis	-	IEA	Process
GO:0061484	hematopoietic stem cell homeostasis	-	IEA	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	IEA	Process
GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.