EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28753127	IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1.	Elife	2017 Jul 28	Dai N	doi: 10.7554/eLife.27155.
15618018	Effect of all-trans-retinoic acid on mRNA binding protein p62 in human gastric cancer cells.	Int J Biochem Cell Biol	2005 Mar	Ping S	-
25661373	Correlation between IGF2BP2 gene polymorphism and the risk of breast cancer in Chinese Han women.	Biomed Pharmacother	2015 Feb	Liu G	doi: 10.1016/j.biopha.2014.12.017
25721883	Autoimmune Response to IGF2 mRNA-Binding Protein 2 (IMP2/p62) in Breast Cancer.	Scand J Immunol	2015 Jun	Liu W	doi: 10.1111/sji.12285.
20142250	Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study.	Cancer Epidemiol Biomarkers Prev	2010 Feb	Meyer TE	doi: 10.1158/1055-9965.EPI-09-0902.
21422097	Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk.	Hum Mol Genet	2011 Jun 1	Pearce CL	doi: 10.1093/hmg/ddr087
26416451	p62/IMP2 stimulates cell migration and reduces cell adhesion in breast cancer.	Oncotarget	2015 Oct 20	Li Y	doi: 10.18632/oncotarget.5328.
19018773	Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic conditions.	Cancer Sci	2008 Dec	Isohashi F	doi: 10.1111/j.1349-7006.2008.00970.x
23421499	Humoral autoimmune response to IGF2 mRNA-binding protein (IMP2/p62) and its tissue-specific expression in colon cancer.	Scand J Immunol	2013 Apr	Liu W	doi: 10.1111/sji.12032.
27733218	miR-1193 Suppresses Proliferation and Invasion of Human Breast Cancer Cells Through Directly Targeting IGF2BP2.	Oncol Res	2017 Apr 14	Li X	doi: 10.3727/97818823455816X14760504645779
29510198	MicroRNA-485-5p suppresses growth and metastasis in non-small cell lung cancer cells by targeting IGF2BP2.	Life Sci	2018 Apr 15	Huang RS	doi: 10.1016/j.lfs.2018.03.005
29217458	IMP2 and IMP3 cooperate to promote the metastasis of triple-negative breast cancer through destabilization of progesterone receptor.	Cancer Lett	2018 Feb 28	Kim HY	doi: 10.1016/j.canlet.2017.11.039
30220054	CCN6 regulates IGF2BP2and HMGA2 signaling in metaplastic carcinomas of the breast.	Breast Cancer Res Treat	2018 Dec	McMullen ER	doi: 10.1007/s10549-018-4960-2

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr3	185672643	Missense_Mutation	novel	L366F	0.41
BLCA	chr3	185645444	3'UTR	novel		0.25
BLCA	chr3	185689582	Silent	rs780675243	F150F	0.38
BLCA	chr3	185652109	Silent	novel	P482P	0.21
BLCA	chr3	185672579	Missense_Mutation	rs771848248	R388C	0.28
BLCA	chr3	185716919	Intron	novel		0.1
BLCA	chr3	185689508	Missense_Mutation	novel	S175F	0.34
BLCA	chr3	185675833	In_Frame_Ins	novel	K298delinsME	0.03
BLCA	chr3	185657308	Missense_Mutation	NA	R455K	0.3
BLCA	chr3	185716471	Intron	novel		0.25
BLCA	chr3	185716645	Intron	novel		0.17
BLCA	chr3	185689472	Missense_Mutation	novel	S187C	0.13
BRCA	chr3	185657308	Missense_Mutation	NA	R455K	0.41
BRCA	chr3	185672635	Missense_Mutation	rs140669105	S369N	0.05
BRCA	chr3	185643861	3'UTR	novel		0.16
BRCA	chr3	185824848	Missense_Mutation	novel	S38Y	0.16	KH_1
BRCA	chr3	185689535	Frame_Shift_Del	novel	*P166Lfs49**	0.11
BRCA	chr3	185675805	Silent	novel	K307K	0.1
BRCA	chr3	185645609	Silent	NA	K574K	0.24
BRCA	chr3	185692709	Nonsense_Mutation	NA	E132*	0.08
BRCA	chr3	185713363	Intron	novel		0.17
BRCA	chr3	185658359	Silent	rs761440241	P417P	0.32
BRCA	chr3	185716842	Intron	NA		0.43
BRCA	chr3	185652127	Silent	NA	V476V	0.27
CESC	chr3	185643913	3'UTR	rs557446446		0.11
CESC	chr3	185644032	3'UTR	novel		0.54
CESC	chr3	185657308	Missense_Mutation	NA	R455K	0.16
CESC	chr3	185645302	3'UTR	novel		0.5
CESC	chr3	185689375	Silent	novel	I219I	0.17
CESC	chr3	185643838	3'UTR	novel		0.29
CESC	chr3	185645477	3'UTR	novel		0.25
CESC	chr3	185675233	Intron	novel		0.3
CESC	chr3	185647037	Missense_Mutation	novel	F565L	0.29
CESC	chr3	185645358	3'UTR	novel		0.29
CESC	chr3	185644642	3'UTR	novel		0.33
CESC	chr3	185643863	3'UTR	novel		0.06
CHOL	chr3	185644328	3'UTR	novel		0.11
CHOL	chr3	185824946	Silent	novel	L5L	0.27
CHOL	chr3	185644294	3'UTR	novel		0.22
COAD	chr3	185649496	Missense_Mutation	NA	N500K	0.39
COAD	chr3	185689609	Silent	rs563013811	S141S	0.4
COAD	chr3	185658353	Silent	rs151111656	P419P	0.47
COAD	chr3	185824820	Missense_Mutation	novel	D47E	0.31	KH_1
COAD	chr3	185675347	Missense_Mutation	novel	E340D	0.49
COAD	chr3	185672633	Missense_Mutation	rs200027200	A370T	0.36
COAD	chr3	185692773	Intron	novel		0.42
COAD	chr3	185649461	Missense_Mutation	rs528084524	A512V	0.17
ESCA	chr3	185643754	3'UTR	rs777833620		0.42
ESCA	chr3	185716762	Intron	novel		0.3
GBM	chr3	185716612	Intron	rs769573932		0.31
GBM	chr3	185649460	Silent	rs757747673	A512A	0.63
HNSC	chr3	185713458	Intron	novel		0.11
HNSC	chr3	185713443	Intron	novel		0.06
HNSC	chr3	185645415	3'UTR	novel		0.3
HNSC	chr3	185645404	3'UTR	novel		0.53
KIRC	chr3	185675402	Missense_Mutation	NA	E322V	0.21
KIRP	chr3	185647128	Missense_Mutation	novel	L535P	0.17
KIRP	chr3	185824955	Missense_Mutation	NA	M2I	0.19
LGG	chr3	185689576	Silent	novel	I152I	0.51
LGG	chr3	185713388	Intron	novel		0.32
LGG	chr3	185675307	Silent	NA	L354L	0.11
LGG	chr3	185675833	In_Frame_Ins	novel	K298delinsME	0.06
LIHC	chr3	185672636	Missense_Mutation	novel	S369C	0.26
LUAD	chr3	185672603	Missense_Mutation	novel	V380L	0.09
LUAD	chr3	185823212	Splice_Region	novel	G60G	0.37
LUAD	chr3	185672565	Frame_Shift_Del	novel	*A393Lfs38**	0.5
LUAD	chr3	185675306	Missense_Mutation	novel	L354P	0.1
LUAD	chr3	185713441	Intron	NA		0.16
LUAD	chr3	185647055	Silent	novel	V559V	0.21
LUAD	chr3	185652118	Silent	rs145090990	T479T	0.15
LUAD	chr3	185657311	Missense_Mutation	novel	A454E	0.57
LUAD	chr3	185687133	Missense_Mutation	NA	A246T	0.35
LUAD	chr3	185716617	Intron	novel		0.35
LUAD	chr3	185658373	Missense_Mutation	NA	H413Y	0.1
LUAD	chr3	185687105	Missense_Mutation	novel	C255F	0.19
LUAD	chr3	185645614	Missense_Mutation	rs758689947	R573C	0.09
LUAD	chr3	185645460	3'UTR	novel		0.16
LUAD	chr3	185649410	Missense_Mutation	novel	G529V	0.15
LUAD	chr3	185672634	Silent	rs757933404	S369S	0.1
LUAD	chr3	185716696	Intron	NA		0.44
LUSC	chr3	185824901	Frame_Shift_Del	novel	*Q21Sfs16**	0.35
LUSC	chr3	185692782	Intron	novel		0.27
LUSC	chr3	185645572	Missense_Mutation	novel	Q587E	0.07
LUSC	chr3	185716667	Intron	novel		0.64
LUSC	chr3	185675328	Missense_Mutation	NA	E347K	0.14
LUSC	chr3	185696621	Missense_Mutation	NA	V111M	0.6
LUSC	chr3	185687058	Missense_Mutation	novel	L271V	0.24
LUSC	chr3	185652158	Missense_Mutation	rs751050074	A466V	0.21
LUSC	chr3	185716482	Intron	novel		0.17
OV	chr3	185647109	In_Frame_Ins	novel	A541_E542insLSL	0.05
PAAD	chr3	185647057	Missense_Mutation	rs759323959	V559I	0.22
PAAD	chr3	185645507	3'UTR	novel		0.19
PAAD	chr3	185689447	Silent	rs746680034	P195P	0.15
PRAD	chr3	185716871	Intron	novel		0.5
PRAD	chr3	185824899	Missense_Mutation	NA	Q21R	0.15
READ	chr3	185645359	3'UTR	novel		0.16
READ	chr3	185647036	Missense_Mutation	novel	F566V	0.15
READ	chr3	185658340	Splice_Site	novel	X423_splice	0.45
READ	chr3	185824866	Missense_Mutation	NA	G32E	0.22	KH_1
SARC	chr3	185689356	Missense_Mutation	rs778292490	R226W	0.34
SARC	chr3	185643987	3'UTR	novel		0.09
SARC	chr3	185689518	Missense_Mutation	novel	G172R	0.22
SKCM	chr3	185657373	Silent	NA	F433F	0.14
SKCM	chr3	185716675	Intron	novel		0.3
SKCM	chr3	185716509	Intron	NA		0.07
SKCM	chr3	185716814	Intron	novel		0.26
SKCM	chr3	185652108	Missense_Mutation	novel	E483K	0.19
SKCM	chr3	185687182	Silent	NA	I229I	0.06
SKCM	chr3	185689429	Silent	NA	P201P	0.3
SKCM	chr3	185689485	Missense_Mutation	rs11558676	P183S	0.15
SKCM	chr3	185647093	Missense_Mutation	NA	R547C	0.42
SKCM	chr3	185647046	Silent	rs541265749	I562I	0.11
SKCM	chr3	185672549	Missense_Mutation	rs192526034	P398S	0.13
SKCM	chr3	185689505	Missense_Mutation	NA	S176F	0.12
SKCM	chr3	185689505	Missense_Mutation	NA	S176F	0.09
SKCM	chr3	185716590	Intron	novel		0.7
SKCM	chr3	185675425	Silent	novel	Q314Q	0.35
SKCM	chr3	185687128	Silent	novel	T247T	0.2
STAD	chr3	185675823	Silent	NA	E301E	0.13
STAD	chr3	185652145	Silent	rs147590133	D470D	0.26
STAD	chr3	185645613	Missense_Mutation	rs750722399	R573H	0.09
STAD	chr3	185687104	Silent	NA	C255C	0.15
STAD	chr3	185645538	Missense_Mutation	NA	S598N	0.18
STAD	chr3	185716602	Intron	novel		0.39
STAD	chr3	185657352	Silent	rs142081639	G440G	0.39
STAD	chr3	185698328	Nonsense_Mutation	rs772496480	R87*	0.2
STAD	chr3	185649445	Silent	novel	P517P	0.1
STAD	chr3	185689433	Missense_Mutation	novel	V200A	0.4
STAD	chr3	185689525	Silent	NA	A169A	0.06
STAD	chr3	185649525	Missense_Mutation	NA	R491W	0.19
STAD	chr3	185672571	Silent	NA	A390A	0.18
STAD	chr3	185672579	Missense_Mutation	rs771848248	R388C	0.13
STAD	chr3	185716709	Intron	novel		0.23
STAD	chr3	185696653	Missense_Mutation	novel	G100A	0.19
STAD	chr3	185716648	Intron	novel		0.33
STAD	chr3	185716736	Intron	novel		0.38
STAD	chr3	185689447	Silent	rs746680034	P195P	0.05
TGCT	chr3	185689542	Missense_Mutation	novel	S164T	0.28
THYM	chr3	185825019	5'UTR	novel		0.32
UCEC	chr3	185645542	Missense_Mutation	rs772894965	R597C	0.32
UCEC	chr3	185657311	Missense_Mutation	rs759073124	A454V	0.21
UCEC	chr3	185687102	Missense_Mutation	NA	R256H	0.48
UCEC	chr3	185824953	Missense_Mutation	novel	N3S	0.41
UCEC	chr3	185716451	Intron	NA		0.09
UCEC	chr3	185649478	Silent	novel	E506E	0.35
UCEC	chr3	185821129	Intron	novel		0.09
UCEC	chr3	185644316	3'UTR	novel		0.11
UCEC	chr3	185645343	3'UTR	novel		0.19
UCEC	chr3	185643870	3'UTR	novel		0.48
UCEC	chr3	185644080	3'UTR	novel		0.5
UCEC	chr3	185675334	Missense_Mutation	novel	L345M	0.39
UCEC	chr3	185644559	3'UTR	novel		0.18
UCEC	chr3	185689563	Missense_Mutation	novel	D157N	0.22
UCEC	chr3	185722192	Intron	novel		0.36
UCEC	chr3	185672607	Silent	rs755528914	L378L	0.5
UCEC	chr3	185644016	3'UTR	novel		0.17
UCEC	chr3	185644366	3'UTR	novel		0.21
UCEC	chr3	185644418	3'UTR	novel		0.26
UCEC	chr3	185716451	Intron	NA		0.18
UCEC	chr3	185672633	Missense_Mutation	rs200027200	A370T	0.22
UCEC	chr3	185687132	Missense_Mutation	novel	A246V	0.08
UCEC	chr3	185645296	3'UTR	novel		0.32
UCEC	chr3	185647122	Missense_Mutation	novel	N537T	0.06
UCEC	chr3	185689447	Silent	rs746680034	P195P	0.36
UCEC	chr3	185716643	Intron	NA		0.41
UCEC	chr3	185644143	3'UTR	novel		0.54
UCEC	chr3	185645349	3'UTR	rs544821602		0.38
UCEC	chr3	185645542	Missense_Mutation	rs772894965	R597C	0.34
UCEC	chr3	185675880	Silent	novel	H282H	0.3
UCEC	chr3	185716577	Intron	rs553492698		0.3
UCEC	chr3	185645267	3'UTR	novel		0.56
UCEC	chr3	185672604	Silent	rs751810583	S379S	0.53
UCEC	chr3	185713355	Intron	novel		0.32
UCEC	chr3	185643763	3'UTR	novel		0.26
UCEC	chr3	185644758	3'UTR	novel		0.33
UCEC	chr3	185658360	Missense_Mutation	rs141112109	P417L	0.27
UCEC	chr3	185649429	Missense_Mutation	NA	R523W	0.39
UCEC	chr3	185643966	3'UTR	novel		0.51
UCEC	chr3	185644924	3'UTR	novel		0.4
UCEC	chr3	185821105	Intron	novel		0.4
UCEC	chr3	185716747	Intron	novel		0.4
UCEC	chr3	185823184	Nonsense_Mutation	novel	E70*	0.5	KH_1
UCEC	chr3	185824781	Splice_Site	novel	X60_splice	0.16
UCEC	chr3	185649404	Missense_Mutation	NA	T531N	0.25
UCEC	chr3	185652119	Missense_Mutation	NA	T479I	0.38
UCEC	chr3	185644707	3'UTR	novel		0.45
UCEC	chr3	185716798	Intron	rs747125205		0.29
UCEC	chr3	185643914	3'UTR	rs749139196		0.4
UCEC	chr3	185657304	Silent	rs199697480	F456F	0.2
UCEC	chr3	185657303	Missense_Mutation	rs773624114	A457T	0.39
UCEC	chr3	185647058	Silent	rs767385552	I558I	0.35
UCEC	chr3	185713379	Intron	novel		0.32
UCEC	chr3	185821039	Intron	novel		0.24
UCEC	chr3	185644316	3'UTR	novel		0.3
UCEC	chr3	185689356	Missense_Mutation	rs778292490	R226W	0.23
UCEC	chr3	185692743	Silent	rs773155755	T120T	0.42
UCEC	chr3	185644316	3'UTR	novel		0.74
UCEC	chr3	185644549	3'UTR	novel		0.52
UCEC	chr3	185675796	Silent	novel	I310I	0.35
UCEC	chr3	185698345	Missense_Mutation	novel	S81N	0.31	KH_1
UCEC	chr3	185644396	3'UTR	novel		0.19
UCEC	chr3	185644933	3'UTR	novel		0.73
UCEC	chr3	185692742	Missense_Mutation	rs554754058	A121T	0.27
UCEC	chr3	185689489	Silent	rs370374613	H181H	0.44
UCEC	chr3	185689437	Missense_Mutation	novel	L199M	0.05
UCEC	chr3	185689625	Missense_Mutation	novel	A136V	0.11
UCEC	chr3	185658370	Nonsense_Mutation	novel	Q414*	0.43
UCEC	chr3	185644877	3'UTR	novel		0.18
UCEC	chr3	185649403	Splice_Region	rs139682125	T531T	0.19
UCEC	chr3	185649493	Missense_Mutation	NA	F501L	0.47
UCEC	chr3	185658373	Missense_Mutation	NA	H413N	0.26
UCEC	chr3	185675357	Missense_Mutation	NA	A337V	0.25
UCEC	chr3	185689579	Missense_Mutation	NA	K151N	0.38
UCEC	chr3	185675851	Frame_Shift_Ins	novel	*K292Rfs12**	0.04
UCEC	chr3	185657376	Silent	novel	L432L	0.28
UCEC	chr3	185689479	Missense_Mutation	novel	G185S	0.24
UCEC	chr3	185716528	Intron	novel		0.27
UCEC	chr3	185644032	3'UTR	novel		0.47
UCEC	chr3	185692739	Missense_Mutation	novel	V122F	0.45
UCEC	chr3	185687147	Missense_Mutation	NA	P241H	0.31
UCEC	chr3	185644316	3'UTR	novel		0.4
UCEC	chr3	185644595	3'UTR	rs56297111		0.45
UCEC	chr3	185689388	Missense_Mutation	novel	T215I	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.4363	0.0018563
KIRC	AMP	0.1193	2.0306e-05
KIRP	AMP	0.3194	0.15981
LUAD	DEL	0.1802	0.010111
PAAD	AMP	0.1033	0.16151
SARC	DEL	0.1518	0.0086757
TGCT	AMP	0.2533	7.0307e-05

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.016	Kaplan-Meier Survival Analysis
MESO	0.00055	Kaplan-Meier Survival Analysis
ACC	0.013	Kaplan-Meier Survival Analysis
HNSC	0.00015	Kaplan-Meier Survival Analysis
COAD	0.042	Kaplan-Meier Survival Analysis
PAAD	0.00047	Kaplan-Meier Survival Analysis
PCPG	0.038	Kaplan-Meier Survival Analysis
BLCA	0.0024	Kaplan-Meier Survival Analysis
LAML	0.0093	Kaplan-Meier Survival Analysis
UCEC	0.00035	Kaplan-Meier Survival Analysis
LIHC	0.0041	Kaplan-Meier Survival Analysis
THCA	0.023	Kaplan-Meier Survival Analysis
LUAD	0.00095	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000073792 (Gene tree)
Gene ID: 10644
Gene Symbol: IGF2BP2
Alias: IMP-2
Full Name: insulin like growth factor 2 mRNA binding protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 181,926 bases
Position: chr3:185,643,131-185,825,056
Accession: 28867
RBP type: canonical RBP
Summary: This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000413787	KH_1	PF00013.29	5.1e-54	1	4
ENSP00000413787	KH_1	PF00013.29	5.1e-54	2	4
ENSP00000413787	KH_1	PF00013.29	5.1e-54	3	4
ENSP00000413787	KH_1	PF00013.29	5.1e-54	4	4
ENSP00000320204	KH_1	PF00013.29	6.1e-54	1	4
ENSP00000320204	KH_1	PF00013.29	6.1e-54	2	4
ENSP00000320204	KH_1	PF00013.29	6.1e-54	3	4
ENSP00000320204	KH_1	PF00013.29	6.1e-54	4	4
ENSP00000371634	KH_1	PF00013.29	9.3e-54	1	4
ENSP00000371634	KH_1	PF00013.29	9.3e-54	2	4
ENSP00000371634	KH_1	PF00013.29	9.3e-54	3	4
ENSP00000371634	KH_1	PF00013.29	9.3e-54	4	4
ENSP00000410242	KH_1	PF00013.29	1e-53	1	4
ENSP00000410242	KH_1	PF00013.29	1e-53	2	4
ENSP00000410242	KH_1	PF00013.29	1e-53	3	4
ENSP00000410242	KH_1	PF00013.29	1e-53	4	4
ENSP00000320204	RRM_1	PF00076.22	1.4e-17	1	2
ENSP00000320204	RRM_1	PF00076.22	1.4e-17	2	2
ENSP00000371634	RRM_1	PF00076.22	1.7e-17	1	2
ENSP00000371634	RRM_1	PF00076.22	1.7e-17	2	2
ENSP00000410242	RRM_1	PF00076.22	1.4e-16	1	2
ENSP00000410242	RRM_1	PF00076.22	1.4e-16	2	2
ENSP00000413787	RRM_1	PF00076.22	2.4e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23640942	Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains.	Biol Chem	2013 Aug	Wachter K	doi: 10.1515/hsz-2013-0111.
16049158	Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.	Reproduction	2005 Aug	Hammer NA	-
23069990	Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?	Cell Mol Life Sci	2013 Aug	Bell JL	doi: 10.1007/s00018-012-1186-z
12674497	Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D).	Biol Chem	2003 Jan	Moraes KC	-
11713986	A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking.	Scand J Clin Lab Invest Suppl	2001	Nielsen FC	-
22513850	RNA-binding protein IGF2BP2/IMP2 is required for laminin-β2 mRNA translation and is modulated by glucose concentration.	Am J Physiol Renal Physiol	2012 Jul 1	Schaeffer V	doi: 10.1152/ajprenal.00185.2012
21576258	mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.	Genes Dev	2011 Jun 1	Dai N	doi: 10.1101/gad.2042311
20956565	Role of the RNA-binding protein IMP-2 in muscle cell motility.	Mol Cell Biol	2010 Dec	Boudoukha S	doi: 10.1128/MCB.00665-10
23177649	An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis.	Dev Cell	2012 Dec 11	Li Z	doi: 10.1016/j.devcel.2012.10.019
25606370	No detectable association of IGF2BP2 and SLC30A8 genes with type 2 diabetes in the population of Hyderabad, India.	Meta Gene	2013 Oct 15	Kommoju UJ	doi: 10.1016/j.mgene.2013.09.003
24713990	Oncofetal protein IMP3, a new cancer biomarker.	Adv Anat Pathol	2014 May	Gong Y	doi: 10.1097/PAP.0000000000000021.
24613920	MiRNA let-7g regulates skeletal myoblast motility via Pinch-2.	FEBS Lett	2014 May 2	Boudoukha S	doi: 10.1016/j.febslet.2014.02.057
27385015	IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories.	Development	2016 Aug 1	Preitner N	doi: 10.1242/dev.128348
27184842	The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing.	Cell Rep	2016 May 24	Degrauwe N	doi: 10.1016/j.celrep.2016.04.086
25863250	IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.	Cell Metab	2015 Apr 7	Dai N	doi: 10.1016/j.cmet.2015.03.006.
25821834	Use of Drosophila as an evaluation method reveals imp as a candidate gene for type 2 diabetes in rat locus Niddm22.	J Diabetes Res	2015	Kawasaki K	doi: 10.1155/2015/758564
29859241	Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis.	Biochim Biophys Acta Mol Basis Dis	2018 Oct	Dehghani Amirabad A	doi: 10.1016/j.bbadis.2018.05.024
31350345	Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA.	Proc Natl Acad Sci U S A	2019 Jul 26	Khyzha N	doi: 10.1073/pnas.1904108116
31089713	Insulin-like growth factor 2 mRNA binding protein 2 promotes aerobic glycolysis and cell proliferation in pancreatic ductal adenocarcinoma via stabilizing GLUT1 mRNA.	Acta Biochim Biophys Sin (Shanghai)	2019 Jul 10	Huang S	doi: 10.1093/abbs/gmz048.
29483092	Airn Regulates Igf2bp2 Translation in Cardiomyocytes.	Circ Res	2018 May 11	Hosen MR	doi: 10.1161/CIRCRESAHA.117.312215
30243807	The expression and biological information analysis of miR-375-3p in head and neck squamous cell carcinoma based on 1825 samples from GEO, TCGA, and peer-reviewed publications.	Pathol Res Pract	2018 Nov	Cen WN	doi: 10.1016/j.prp.2018.09.010
19429674	IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes.	J Mol Endocrinol	2009 Nov	Christiansen J	doi: 10.1677/JME-09-0016
23656854	The type 2 diabetes mellitus susceptibility gene IGF2BP2 is associated with schizophrenia in a Han Chinese population.	J Clin Psychiatry	2013 Apr	Zhang X	doi: 10.4088/JCP.12m07846.
27068461	Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival.	Cell Rep	2016 Apr 19	Conway AE	doi: 10.1016/j.celrep.2016.03.052

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000346192	IGF2BP2-201	3291	XM_017005558	ENSP00000320204	556 (aa)	XP_016861047	Q9Y6M1
ENST00000461957	IGF2BP2-205	509	-	-	- (aa)	-	-
ENST00000457616	IGF2BP2-204	3426	XM_017005559	ENSP00000410242	605 (aa)	XP_016861048	F8W930
ENST00000421047	IGF2BP2-203	1711	XM_006713477	ENSP00000413787	536 (aa)	XP_006713540	Q9Y6M1
ENST00000496495	IGF2BP2-211	472	-	-	- (aa)	-	-
ENST00000494906	IGF2BP2-210	918	-	-	- (aa)	-	-
ENST00000382199	IGF2BP2-202	3688	XM_017005557	ENSP00000371634	599 (aa)	XP_016861046	Q9Y6M1
ENST00000464166	IGF2BP2-206	380	-	-	- (aa)	-	-
ENST00000466476	IGF2BP2-208	469	-	-	- (aa)	-	-
ENST00000466214	IGF2BP2-207	138	-	-	- (aa)	-	-
ENST00000493302	IGF2BP2-209	358	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000073792's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000073792	Life Expectancy	4.00831229478982E-5	17903295
ENSG00000073792	Life Expectancy	7.30888620574799E-5	17903295
ENSG00000073792	Heart Failure	8.8011249E-005	-
ENSG00000073792	Blood Pressure	9.0190000E-005	-
ENSG00000073792	Platelet Function Tests	1.7248600E-005	-
ENSG00000073792	Diabetes Mellitus, Type 2	2E-9	17463246
ENSG00000073792	Diabetes Mellitus, Type 2	9E-16	17463248
ENSG00000073792	Diabetes Mellitus, Type 2	9E-16	17463249
ENSG00000073792	Diabetes Mellitus, Type 2	1E-7	21573907
ENSG00000073792	Diabetes Mellitus, Type 2	1E-6	19401414
ENSG00000073792	Glucose	6E-7	22581228
ENSG00000073792	Body Mass Index	6E-7	22581228
ENSG00000073792	Diabetes Mellitus, Type 2	3E-9	22693455
ENSG00000073792	Diabetes Mellitus, Type 2	2E-9	20581827
ENSG00000073792	Diabetes Mellitus, Type 2	5E-6	23300278
ENSG00000073792	Diabetes Mellitus, Type 2	4E-7	23300278
ENSG00000073792	Diabetes Mellitus, Type 2	4E-9	23300278
ENSG00000073792	Diabetes Mellitus, Type 2	2E-13	23300278
ENSG00000073792	Diabetes Mellitus, Type 2	2E-19	23300278
ENSG00000073792	Diabetes Mellitus, Type 2	1E-9	18711366
ENSG00000073792	Diabetes Mellitus, Type 2	1E-17	24509480
ENSG00000073792	Diabetes Mellitus, Type 2	3E-14	27189021
ENSG00000073792	Diabetes Mellitus, Type 2	8E-8	18372903
ENSG00000073792	Diabetes Mellitus, Type 2	2E-24	26818947
ENSG00000073792	Diabetes Mellitus, Type 2	5E-14	23945395
ENSG00000073792	Diabetes, Gestational	2E-7	22233651

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000073792	rs4402960	3	185793899	T	Type 2 diabetes	22885922	[1.10-1.16]	1.13	EFO_0001360
ENSG00000073792	rs7640539	3	185795508	A	Type 2 diabetes	22885922	[1.11-1.18]	1.14	EFO_0001360
ENSG00000073792	rs7640539	3	185795508	A	Type 2 diabetes	22885922	[1.07-1.15]	1.11	EFO_0001360
ENSG00000073792	rs13092876	3	185777532	A	Coronary artery disease	29212778	[0.017-0.045] unit increase	0.031	EFO_0000378
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	26818947	[1.13996358956295-1.21326535811954]	1.176043	EFO_0001360
ENSG00000073792	rs11927381	3	185790803	C	Type 2 diabetes	27189021	[1.10-1.17]	1.14	EFO_0001360
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	23945395	[1.14-1.24]	1.19	EFO_0001360
ENSG00000073792	rs4402960	3	185793899	T	Type 2 diabetes	22693455	[1.10-1.21]	1.15	EFO_0001360
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	20581827	[1.09-1.19]	1.14	EFO_0001360
ENSG00000073792	rs4402960	3	185793899	T	Type 2 diabetes	24509480	[1.09-1.17]	1.13	EFO_0001360
ENSG00000073792	rs6769511	3	185812502	C	Type 2 diabetes	18711366	[1.15-1.31]	1.23	EFO_0001360
ENSG00000073792	rs4402960	3	185793899	T	Type 2 diabetes	19401414	[1.08-1.21]	1.14	EFO_0001360
ENSG00000073792	rs4402960	3	185793899	T	Type 2 diabetes	17463246	[1.11-1.18]	1.14	EFO_0001360
ENSG00000073792	rs4402960	3	185793899	T	Type 2 diabetes	17463248	[1.11-1.18]	1.14	EFO_0001360
ENSG00000073792	rs4402960	3	185793899	T	Type 2 diabetes	17463249	[1.11-1.18]	1.14	EFO_0001360
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	23300278	[1.11-1.28]	1.19	EFO_0001360
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	23300278	[1.09-1.20]	1.14	EFO_0001360
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	23300278	[1.04-1.09]	1.06	EFO_0001360
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	23300278	[1.04-1.08]	1.06	EFO_0001360
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	23300278	[1.05-1.09]	1.08	EFO_0001360
ENSG00000073792	rs1470579	3	185811292	A	Fasting blood glucose (BMI interaction)	22581228	[0.00071-0.00349] unit decrease	0.0021	EFO_0004340\|EFO_0004465
ENSG00000073792	rs4686392	3	185806293	G	Body mass index	28892062	[0.024-0.04] kg/m2 decrease	0.032	EFO_0004340
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	28869590	[0.11-0.15] unit increase	0.13	EFO_0001360
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	28869590	[0.074-0.133] unit increase	0.1031	EFO_0001360
ENSG00000073792	rs1470579	3	185811292	C	Type 2 diabetes	28869590	[0.094-0.159] unit increase	0.1264	EFO_0001360
ENSG00000073792	rs71320321	3	185801319	A	Type 2 diabetes	29358691		1.1456819	EFO_0001360
ENSG00000073792	rs11705729	3	185789511	?	Blood sugar levels	29403010	[0.02-0.039] unit increase novel	0.02946	EFO_0004468
ENSG00000073792	rs76922886	3	185801133	?	Hemoglobin A1c levels	29403010	[0.042-0.071] unit increase novel	0.05676	EFO_0004541
ENSG00000073792	rs35430985	3	185770515	A	Plateletcrit	27863252	[0.023-0.039] unit decrease	0.03068133	EFO_0007985
ENSG00000073792	rs35430985	3	185770515	A	Platelet count	27863252	[0.017-0.034] unit decrease	0.02543329	EFO_0004309
ENSG00000073792	rs4402960	3	185793899	T	Peak insulin response	28490609	[0.058-0.144] pmol/l decrease	0.101	EFO_0008000
ENSG00000073792	rs1470579	3	185811292	C	Diabetes (gestational)	22233651	[1.197-1.484]	1.332	EFO_0004593
ENSG00000073792	rs4402960	3	185793899	T	Type 2 diabetes	18372903	[1.10-1.25]	1.17	EFO_0001360
ENSG00000073792	rs1374910	3	185813873	T	Type 2 diabetes	21573907	[1.15-1.34]	1.24	EFO_0001360
ENSG00000073792	rs7651090	3	185795604	G	Acute insulin response	28490609	[0.056-0.142] unit decrease	0.099	EFO_0006831
ENSG00000073792	rs55966029	3	185661297	?	General cognitive ability	29844566	z-score increase	4.953	EFO_0004337
ENSG00000073792	rs7651090	3	185795604	G	Type 2 diabetes	30054458	[0.11-0.14] unit increase	0.1204	EFO_0001360
ENSG00000073792	rs4402960	3	185793899	T	Type 2 diabetes	26961502	[1.11-1.2]	1.155	EFO_0001360
ENSG00000073792	rs558655224	3	185804437	?	Heel bone mineral density	30048462	[0.011-0.02] unit decrease	0.0157385	EFO_0009270
ENSG00000073792	rs6769511	3	185812502	T	Heel bone mineral density	30598549	[0.011-0.019] unit decrease	0.0149742	EFO_0009270
ENSG00000073792	rs7633675	3	185792825	?	Type 2 diabetes	30595370			EFO_0001360
ENSG00000073792	rs13100823	3	185796300	T	Thyroid stimulating hormone	30367059	[0.03-0.054] unit decrease	0.042	EFO_0004748
ENSG00000073792	rs58983732	3	185738387	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000073792	rs6780171	3	185785668	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000073792	rs6780171	3	185785668	A	Lung function (FVC)	30804560	[0.0081-0.0179] unit decrease	0.013	EFO_0004312
ENSG00000073792	rs6780171	3	185785668	A	FEV1	30804560	[0.013-0.022] unit decrease	0.0174	EFO_0004314
ENSG00000073792	rs6780171	3	185785668	A	Peak expiratory flow	30804560	[0.019-0.029] unit decrease	0.0241
ENSG00000073792	rs34782298	3	185803208	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000073792's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000073792	IGF2BP2	76	33.696	ENSG00000169564	PCBP1	56	32.143
ENSG00000073792	IGF2BP2	69	36.296	ENSG00000183570	PCBP3	98	36.567
ENSG00000073792	IGF2BP2	98	65.144	ENSG00000136231	IGF2BP3	96	65.530
ENSG00000073792	IGF2BP2	68	32.800	ENSG00000090097	PCBP4	93	31.034
ENSG00000073792	IGF2BP2	68	35.075	ENSG00000197111	PCBP2	98	36.800
ENSG00000073792	IGF2BP2	63	30.726	ENSG00000139910	NOVA1	65	33.803
ENSG00000073792	IGF2BP2	99	65.685	ENSG00000159217	IGF2BP1	95	67.883

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000073792	IGF2BP2	99	75.868	ENSAPOG00000004098	igf2bp2a	96	74.873	Acanthochromis_polyacanthus
ENSG00000073792	IGF2BP2	100	98.497	ENSAMEG00000016763	IGF2BP2	100	98.497	Ailuropoda_melanoleuca
ENSG00000073792	IGF2BP2	99	74.627	ENSACIG00000001308	igf2bp2b	99	73.300	Amphilophus_citrinellus
ENSG00000073792	IGF2BP2	99	72.667	ENSAOCG00000016871	igf2bp2b	96	71.355	Amphiprion_ocellaris
ENSG00000073792	IGF2BP2	99	75.828	ENSAPEG00000016037	igf2bp2a	96	74.830	Amphiprion_percula
ENSG00000073792	IGF2BP2	99	79.892	ENSATEG00000020389	igf2bp2b	99	79.892	Anabas_testudineus
ENSG00000073792	IGF2BP2	99	84.692	ENSACAG00000007995	IGF2BP2	78	84.692	Anolis_carolinensis
ENSG00000073792	IGF2BP2	100	99.640	ENSANAG00000031810	IGF2BP2	100	99.640	Aotus_nancymaae
ENSG00000073792	IGF2BP2	99	79.533	ENSACLG00000015512	igf2bp2a	99	79.533	Astatotilapia_calliptera
ENSG00000073792	IGF2BP2	99	74.007	ENSAMXG00000032347	igf2bp2b	96	70.137	Astyanax_mexicanus
ENSG00000073792	IGF2BP2	73	70.683	ENSAMXG00000029202	-	92	70.711	Astyanax_mexicanus
ENSG00000073792	IGF2BP2	100	98.921	ENSBTAG00000007666	IGF2BP2	100	98.921	Bos_taurus
ENSG00000073792	IGF2BP2	100	99.460	ENSCJAG00000014731	IGF2BP2	100	99.460	Callithrix_jacchus
ENSG00000073792	IGF2BP2	97	98.266	ENSCAFG00000013297	IGF2BP2	100	98.305	Canis_familiaris
ENSG00000073792	IGF2BP2	100	98.497	ENSCAFG00020005444	IGF2BP2	100	98.497	Canis_lupus_dingo
ENSG00000073792	IGF2BP2	100	98.497	ENSCHIG00000015258	IGF2BP2	100	98.497	Capra_hircus
ENSG00000073792	IGF2BP2	100	97.761	ENSTSYG00000003376	IGF2BP2	100	98.790	Carlito_syrichta
ENSG00000073792	IGF2BP2	96	95.551	ENSCAPG00000003061	IGF2BP2	95	97.239	Cavia_aperea
ENSG00000073792	IGF2BP2	97	98.073	ENSCPOG00000005471	IGF2BP2	100	98.145	Cavia_porcellus
ENSG00000073792	IGF2BP2	100	99.460	ENSCCAG00000034879	IGF2BP2	100	99.460	Cebus_capucinus
ENSG00000073792	IGF2BP2	100	99.820	ENSCATG00000036407	IGF2BP2	100	99.820	Cercocebus_atys
ENSG00000073792	IGF2BP2	95	73.585	ENSCATG00000035160	-	98	73.585	Cercocebus_atys
ENSG00000073792	IGF2BP2	96	82.804	ENSCATG00000033281	-	99	80.498	Cercocebus_atys
ENSG00000073792	IGF2BP2	97	98.073	ENSCLAG00000014808	IGF2BP2	100	98.145	Chinchilla_lanigera
ENSG00000073792	IGF2BP2	100	99.332	ENSCSAG00000014019	IGF2BP2	100	99.332	Chlorocebus_sabaeus
ENSG00000073792	IGF2BP2	92	73.469	ENSCHOG00000009982	-	92	74.931	Choloepus_hoffmanni
ENSG00000073792	IGF2BP2	100	86.667	ENSCPBG00000007370	IGF2BP2	100	86.667	Chrysemys_picta_bellii
ENSG00000073792	IGF2BP2	100	82.194	ENSCANG00000030550	-	100	82.194	Colobus_angolensis_palliatus
ENSG00000073792	IGF2BP2	100	99.820	ENSCANG00000008906	IGF2BP2	100	99.820	Colobus_angolensis_palliatus
ENSG00000073792	IGF2BP2	100	94.658	ENSCGRG00001019401	Igf2bp2	100	94.658	Cricetulus_griseus_chok1gshd
ENSG00000073792	IGF2BP2	97	93.834	ENSCGRG00000016050	Igf2bp2	100	93.974	Cricetulus_griseus_crigri
ENSG00000073792	IGF2BP2	99	75.331	ENSCSEG00000011718	igf2bp2b	99	74.338	Cynoglossus_semilaevis
ENSG00000073792	IGF2BP2	99	78.311	ENSCVAG00000004656	igf2bp2b	99	77.318	Cyprinodon_variegatus
ENSG00000073792	IGF2BP2	75	74.690	ENSDARG00000099758	igf2bp2b	88	79.167	Danio_rerio
ENSG00000073792	IGF2BP2	99	77.558	ENSDARG00000003421	igf2bp2a	100	76.238	Danio_rerio
ENSG00000073792	IGF2BP2	97	95.568	ENSDNOG00000013421	IGF2BP2	98	95.577	Dasypus_novemcinctus
ENSG00000073792	IGF2BP2	97	94.990	ENSDORG00000000886	Igf2bp2	100	95.000	Dipodomys_ordii
ENSG00000073792	IGF2BP2	86	90.000	ENSETEG00000012128	-	81	72.690	Echinops_telfairi
ENSG00000073792	IGF2BP2	100	91.727	ENSEASG00005013866	IGF2BP2	100	91.727	Equus_asinus_asinus
ENSG00000073792	IGF2BP2	100	97.830	ENSECAG00000020685	IGF2BP2	100	97.830	Equus_caballus
ENSG00000073792	IGF2BP2	97	76.493	ENSEEUG00000009674	IGF2BP2	100	77.365	Erinaceus_europaeus
ENSG00000073792	IGF2BP2	96	81.481	ENSELUG00000010676	igf2bp2a	98	81.481	Esox_lucius
ENSG00000073792	IGF2BP2	100	99.101	ENSFCAG00000005369	IGF2BP2	100	99.101	Felis_catus
ENSG00000073792	IGF2BP2	97	83.333	ENSFALG00000013346	IGF2BP2	100	83.519	Ficedula_albicollis
ENSG00000073792	IGF2BP2	97	98.651	ENSFDAG00000015039	IGF2BP2	100	98.701	Fukomys_damarensis
ENSG00000073792	IGF2BP2	99	74.240	ENSFHEG00000008263	igf2bp2a	99	74.240	Fundulus_heteroclitus
ENSG00000073792	IGF2BP2	95	76.034	ENSGMOG00000019327	igf2bp2b	94	76.207	Gadus_morhua
ENSG00000073792	IGF2BP2	99	86.957	ENSGALG00000033195	IGF2BP2	92	86.957	Gallus_gallus
ENSG00000073792	IGF2BP2	99	76.974	ENSGAFG00000010504	igf2bp2b	99	77.138	Gambusia_affinis
ENSG00000073792	IGF2BP2	99	78.136	ENSGACG00000005991	igf2bp2b	99	78.136	Gasterosteus_aculeatus
ENSG00000073792	IGF2BP2	100	86.667	ENSGAGG00000008990	IGF2BP2	100	86.667	Gopherus_agassizii
ENSG00000073792	IGF2BP2	100	89.964	ENSGGOG00000038298	-	100	89.964	Gorilla_gorilla
ENSG00000073792	IGF2BP2	100	100.000	ENSGGOG00000015035	IGF2BP2	100	100.000	Gorilla_gorilla
ENSG00000073792	IGF2BP2	100	90.108	ENSGGOG00000024907	-	100	90.108	Gorilla_gorilla
ENSG00000073792	IGF2BP2	99	79.533	ENSHBUG00000003126	igf2bp2a	99	79.533	Haplochromis_burtoni
ENSG00000073792	IGF2BP2	100	85.976	ENSHGLG00000016529	IGF2BP2	100	97.866	Heterocephalus_glaber_female
ENSG00000073792	IGF2BP2	97	97.688	ENSHGLG00100014188	IGF2BP2	100	97.774	Heterocephalus_glaber_male
ENSG00000073792	IGF2BP2	95	71.181	ENSHCOG00000018090	igf2bp2b	100	76.046	Hippocampus_comes
ENSG00000073792	IGF2BP2	99	71.010	ENSIPUG00000022106	Igf2bp2	100	69.839	Ictalurus_punctatus
ENSG00000073792	IGF2BP2	100	99.101	ENSSTOG00000022077	IGF2BP2	100	99.101	Ictidomys_tridecemlineatus
ENSG00000073792	IGF2BP2	100	95.993	ENSJJAG00000015876	Igf2bp2	100	95.993	Jaculus_jaculus
ENSG00000073792	IGF2BP2	99	77.778	ENSKMAG00000012177	igf2bp2b	99	77.778	Kryptolebias_marmoratus
ENSG00000073792	IGF2BP2	85	70.626	ENSLBEG00000003710	IGF2BP2	97	74.803	Labrus_bergylta
ENSG00000073792	IGF2BP2	97	79.245	ENSLACG00000011546	IGF2BP2	97	78.908	Latimeria_chalumnae
ENSG00000073792	IGF2BP2	99	79.667	ENSLOCG00000009564	igf2bp2b	99	78.500	Lepisosteus_oculatus
ENSG00000073792	IGF2BP2	97	98.266	ENSLAFG00000017156	IGF2BP2	100	98.269	Loxodonta_africana
ENSG00000073792	IGF2BP2	93	81.687	ENSMFAG00000002557	-	95	81.687	Macaca_fascicularis
ENSG00000073792	IGF2BP2	100	99.820	ENSMFAG00000039540	IGF2BP2	100	99.820	Macaca_fascicularis
ENSG00000073792	IGF2BP2	100	99.440	ENSMMUG00000023416	IGF2BP2	100	99.623	Macaca_mulatta
ENSG00000073792	IGF2BP2	100	84.353	ENSMMUG00000043560	-	100	84.353	Macaca_mulatta
ENSG00000073792	IGF2BP2	100	74.281	ENSMNEG00000032558	-	100	74.281	Macaca_nemestrina
ENSG00000073792	IGF2BP2	93	82.353	ENSMNEG00000034048	-	90	82.353	Macaca_nemestrina
ENSG00000073792	IGF2BP2	100	99.640	ENSMNEG00000042466	IGF2BP2	100	99.640	Macaca_nemestrina
ENSG00000073792	IGF2BP2	100	99.440	ENSMLEG00000039422	IGF2BP2	100	99.798	Mandrillus_leucophaeus
ENSG00000073792	IGF2BP2	93	74.759	ENSMLEG00000030453	-	98	74.759	Mandrillus_leucophaeus
ENSG00000073792	IGF2BP2	99	79.892	ENSMAMG00000000969	igf2bp2b	99	79.892	Mastacembelus_armatus
ENSG00000073792	IGF2BP2	99	76.661	ENSMZEG00005007777	igf2bp2a	99	76.661	Maylandia_zebra
ENSG00000073792	IGF2BP2	97	85.769	ENSMGAG00000002904	IGF2BP2	100	85.797	Meleagris_gallopavo
ENSG00000073792	IGF2BP2	100	93.823	ENSMAUG00000008302	Igf2bp2	100	93.823	Mesocricetus_auratus
ENSG00000073792	IGF2BP2	100	99.281	ENSMICG00000049453	-	100	99.281	Microcebus_murinus
ENSG00000073792	IGF2BP2	97	89.595	ENSMICG00000037971	-	100	87.594	Microcebus_murinus
ENSG00000073792	IGF2BP2	100	95.826	ENSMOCG00000019099	Igf2bp2	100	95.826	Microtus_ochrogaster
ENSG00000073792	IGF2BP2	99	74.955	ENSMMOG00000003830	igf2bp2b	99	74.955	Mola_mola
ENSG00000073792	IGF2BP2	93	82.600	ENSMODG00000002822	IGF2BP2	100	81.373	Monodelphis_domestica
ENSG00000073792	IGF2BP2	99	77.649	ENSMALG00000016964	igf2bp2b	96	77.551	Monopterus_albus
ENSG00000073792	IGF2BP2	100	94.491	MGP_CAROLIEiJ_G0020601	Igf2bp2	100	94.491	Mus_caroli
ENSG00000073792	IGF2BP2	100	94.658	ENSMUSG00000033581	Igf2bp2	100	94.658	Mus_musculus
ENSG00000073792	IGF2BP2	100	88.481	MGP_PahariEiJ_G0016305	Igf2bp2	100	88.481	Mus_pahari
ENSG00000073792	IGF2BP2	100	94.658	MGP_SPRETEiJ_G0021497	Igf2bp2	100	94.658	Mus_spretus
ENSG00000073792	IGF2BP2	98	73.022	ENSMPUG00000007784	-	98	73.077	Mustela_putorius_furo
ENSG00000073792	IGF2BP2	100	80.467	ENSMPUG00000003151	-	100	81.803	Mustela_putorius_furo
ENSG00000073792	IGF2BP2	97	96.346	ENSMLUG00000002631	IGF2BP2	100	96.429	Myotis_lucifugus
ENSG00000073792	IGF2BP2	94	96.032	ENSNGAG00000012680	Igf2bp2	94	96.032	Nannospalax_galili
ENSG00000073792	IGF2BP2	99	76.285	ENSNBRG00000016140	igf2bp2b	99	75.290	Neolamprologus_brichardi
ENSG00000073792	IGF2BP2	97	75.577	ENSNLEG00000027269	-	100	82.822	Nomascus_leucogenys
ENSG00000073792	IGF2BP2	97	72.832	ENSNLEG00000032080	-	98	79.412	Nomascus_leucogenys
ENSG00000073792	IGF2BP2	97	99.807	ENSNLEG00000006508	IGF2BP2	99	99.807	Nomascus_leucogenys
ENSG00000073792	IGF2BP2	97	81.888	ENSOPRG00000002928	IGF2BP2	100	81.888	Ochotona_princeps
ENSG00000073792	IGF2BP2	100	97.500	ENSODEG00000001231	IGF2BP2	100	97.500	Octodon_degus
ENSG00000073792	IGF2BP2	99	77.243	ENSONIG00000009029	igf2bp2b	99	77.295	Oreochromis_niloticus
ENSG00000073792	IGF2BP2	97	84.261	ENSOANG00000004648	IGF2BP2	100	87.474	Ornithorhynchus_anatinus
ENSG00000073792	IGF2BP2	100	98.664	ENSOCUG00000005057	IGF2BP2	100	98.664	Oryctolagus_cuniculus
ENSG00000073792	IGF2BP2	99	76.442	ENSORLG00000016532	igf2bp2b	99	76.910	Oryzias_latipes
ENSG00000073792	IGF2BP2	99	76.529	ENSORLG00020001556	igf2bp2b	99	77.114	Oryzias_latipes_hni
ENSG00000073792	IGF2BP2	99	76.529	ENSORLG00015001778	igf2bp2b	99	77.114	Oryzias_latipes_hsok
ENSG00000073792	IGF2BP2	99	76.882	ENSOMEG00000001908	igf2bp2b	98	78.417	Oryzias_melastigma
ENSG00000073792	IGF2BP2	97	97.701	ENSOGAG00000010577	IGF2BP2	100	97.753	Otolemur_garnettii
ENSG00000073792	IGF2BP2	100	98.331	ENSOARG00000020556	IGF2BP2	100	98.331	Ovis_aries
ENSG00000073792	IGF2BP2	100	84.794	ENSPPAG00000002120	-	100	84.794	Pan_paniscus
ENSG00000073792	IGF2BP2	100	100.000	ENSPPAG00000034539	IGF2BP2	100	100.000	Pan_paniscus
ENSG00000073792	IGF2BP2	100	86.331	ENSPPAG00000035134	-	100	86.331	Pan_paniscus
ENSG00000073792	IGF2BP2	100	90.647	ENSPPAG00000038959	-	100	90.647	Pan_paniscus
ENSG00000073792	IGF2BP2	100	99.101	ENSPPRG00000003987	IGF2BP2	100	99.101	Panthera_pardus
ENSG00000073792	IGF2BP2	100	97.201	ENSPTIG00000013652	IGF2BP2	100	97.201	Panthera_tigris_altaica
ENSG00000073792	IGF2BP2	100	85.791	ENSPTRG00000049696	-	100	85.791	Pan_troglodytes
ENSG00000073792	IGF2BP2	100	85.331	ENSPTRG00000046113	-	100	85.331	Pan_troglodytes
ENSG00000073792	IGF2BP2	100	100.000	ENSPTRG00000015705	IGF2BP2	100	100.000	Pan_troglodytes
ENSG00000073792	IGF2BP2	100	84.712	ENSPANG00000033514	-	100	84.712	Papio_anubis
ENSG00000073792	IGF2BP2	100	99.820	ENSPANG00000007053	IGF2BP2	100	99.820	Papio_anubis
ENSG00000073792	IGF2BP2	99	78.311	ENSPKIG00000009855	igf2bp2b	99	78.146	Paramormyrops_kingsleyae
ENSG00000073792	IGF2BP2	85	81.672	ENSPSIG00000013917	IGF2BP2	95	84.300	Pelodiscus_sinensis
ENSG00000073792	IGF2BP2	96	70.238	ENSPMGG00000011823	igf2bp2a	96	69.542	Periophthalmus_magnuspinnatus
ENSG00000073792	IGF2BP2	60	77.838	ENSPMAG00000005047	igf2bp2b	92	71.041	Petromyzon_marinus
ENSG00000073792	IGF2BP2	93	73.697	ENSPCIG00000023547	-	97	73.460	Phascolarctos_cinereus
ENSG00000073792	IGF2BP2	99	77.265	ENSPFOG00000007221	igf2bp2b	99	77.924	Poecilia_formosa
ENSG00000073792	IGF2BP2	99	76.840	ENSPLAG00000005993	igf2bp2b	99	76.840	Poecilia_latipinna
ENSG00000073792	IGF2BP2	99	86.239	ENSPMEG00000001726	igf2bp2b	99	86.239	Poecilia_mexicana
ENSG00000073792	IGF2BP2	99	87.059	ENSPREG00000009440	igf2bp2b	99	87.059	Poecilia_reticulata
ENSG00000073792	IGF2BP2	95	98.297	ENSPPYG00000014373	-	100	97.403	Pongo_abelii
ENSG00000073792	IGF2BP2	97	83.815	ENSPCAG00000015093	IGF2BP2	100	84.416	Procavia_capensis
ENSG00000073792	IGF2BP2	100	98.921	ENSPCOG00000027031	IGF2BP2	100	98.921	Propithecus_coquereli
ENSG00000073792	IGF2BP2	100	94.157	ENSPVAG00000011494	IGF2BP2	100	94.157	Pteropus_vampyrus
ENSG00000073792	IGF2BP2	99	75.372	ENSPNYG00000001187	igf2bp2b	99	74.380	Pundamilia_nyererei
ENSG00000073792	IGF2BP2	99	73.770	ENSPNAG00000011228	igf2bp2b	100	73.279	Pygocentrus_nattereri
ENSG00000073792	IGF2BP2	75	71.429	ENSPNAG00000013765	-	93	74.262	Pygocentrus_nattereri
ENSG00000073792	IGF2BP2	100	94.992	ENSRNOG00000025946	Igf2bp2	100	94.992	Rattus_norvegicus
ENSG00000073792	IGF2BP2	97	99.615	ENSRBIG00000044700	IGF2BP2	100	99.790	Rhinopithecus_bieti
ENSG00000073792	IGF2BP2	100	75.899	ENSRBIG00000040002	-	100	75.899	Rhinopithecus_bieti
ENSG00000073792	IGF2BP2	100	75.719	ENSRBIG00000004154	-	100	75.719	Rhinopithecus_bieti
ENSG00000073792	IGF2BP2	97	69.098	ENSRROG00000017773	-	99	75.941	Rhinopithecus_roxellana
ENSG00000073792	IGF2BP2	100	78.417	ENSRROG00000038130	-	100	78.417	Rhinopithecus_roxellana
ENSG00000073792	IGF2BP2	100	99.440	ENSRROG00000035074	IGF2BP2	100	99.440	Rhinopithecus_roxellana
ENSG00000073792	IGF2BP2	97	99.037	ENSSBOG00000021548	IGF2BP2	100	99.160	Saimiri_boliviensis_boliviensis
ENSG00000073792	IGF2BP2	97	82.252	ENSSHAG00000013152	IGF2BP2	100	82.095	Sarcophilus_harrisii
ENSG00000073792	IGF2BP2	99	77.049	ENSSFOG00015007770	igf2bp2b	98	77.596	Scleropages_formosus
ENSG00000073792	IGF2BP2	96	74.187	ENSSMAG00000010576	igf2bp2b	94	71.864	Scophthalmus_maximus
ENSG00000073792	IGF2BP2	99	78.974	ENSSDUG00000017581	igf2bp2b	99	77.649	Seriola_dumerili
ENSG00000073792	IGF2BP2	99	78.974	ENSSLDG00000007046	igf2bp2b	99	77.649	Seriola_lalandi_dorsalis
ENSG00000073792	IGF2BP2	99	84.983	ENSSPUG00000016649	IGF2BP2	99	84.463	Sphenodon_punctatus
ENSG00000073792	IGF2BP2	97	77.419	ENSSPAG00000000521	IGF2BP2	96	76.125	Stegastes_partitus
ENSG00000073792	IGF2BP2	100	99.101	ENSSSCG00000011795	IGF2BP2	100	99.101	Sus_scrofa
ENSG00000073792	IGF2BP2	97	85.385	ENSTGUG00000006719	-	100	85.413	Taeniopygia_guttata
ENSG00000073792	IGF2BP2	99	74.419	ENSTRUG00000009908	igf2bp2b	99	74.007	Takifugu_rubripes
ENSG00000073792	IGF2BP2	99	72.637	ENSTNIG00000016472	igf2bp2b	96	72.402	Tetraodon_nigroviridis
ENSG00000073792	IGF2BP2	84	95.327	ENSTBEG00000006776	IGF2BP2	87	95.327	Tupaia_belangeri
ENSG00000073792	IGF2BP2	97	94.798	ENSTTRG00000008241	IGF2BP2	100	94.674	Tursiops_truncatus
ENSG00000073792	IGF2BP2	75	98.476	ENSUAMG00000001610	-	94	98.476	Ursus_americanus
ENSG00000073792	IGF2BP2	97	98.266	ENSUMAG00000004932	IGF2BP2	100	98.305	Ursus_maritimus
ENSG00000073792	IGF2BP2	57	89.439	ENSVPAG00000012013	-	99	89.439	Vicugna_pacos
ENSG00000073792	IGF2BP2	97	98.266	ENSVVUG00000012616	-	100	98.770	Vulpes_vulpes
ENSG00000073792	IGF2BP2	99	72.772	ENSXCOG00000001170	igf2bp2b	99	73.957	Xiphophorus_couchianus
ENSG00000073792	IGF2BP2	99	76.645	ENSXMAG00000015507	igf2bp2b	99	76.809	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003730	mRNA 3'-UTR binding	20080952.	IDA	Function
GO:0005515	protein binding	12674497.17289661.	IPI	Function
GO:0005634	nucleus	15618018.	IDA	Component
GO:0005737	cytoplasm	15618018.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	15618018.	IDA	Component
GO:0009653	anatomical structure morphogenesis	9891060.	TAS	Process
GO:0017148	negative regulation of translation	9891060.	ISS	Process
GO:0042035	regulation of cytokine biosynthetic process	9891060.	IC	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0045182	translation regulator activity	9891060.	ISS	Function
GO:0048027	mRNA 5'-UTR binding	9891060.	IDA	Function
GO:0051028	mRNA transport	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.