EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr16	1772519	Splice_Region	NA		0.33
BLCA	chr16	1772221	Silent	rs753331473	*219*	0.37
BLCA	chr16	1772450	Missense_Mutation	NA	P143R	0.24
BLCA	chr16	1772510	Missense_Mutation	NA	K123R	0.03
BLCA	chr16	1772509	Missense_Mutation	novel	K123N	0.35
BRCA	chr16	1772499	Missense_Mutation	NA	E127K	0.27
COAD	chr16	1773003	Missense_Mutation	novel	E39D	0.32
ESCA	chr16	1772499	Missense_Mutation	novel	E127Q	0.24
ESCA	chr16	1772357	In_Frame_Ins	novel	I174delinsTPWSIQPLGGPHTFF	0.2
HNSC	chr16	1772092	3'UTR	novel		0.41
HNSC	chr16	1772037	3'UTR	novel		0.57
KICH	chr16	1772531	Intron	novel		0.3
LUAD	chr16	1772356	Silent	novel	I174I	0.56
LUSC	chr16	1772362	Silent	novel	A172A	0.15
LUSC	chr16	1772485	Missense_Mutation	novel	I131M	0.05
LUSC	chr16	1772350	Silent	novel	A176A	0.44
PAAD	chr16	1772317	Missense_Mutation	novel	E187D	0.19
READ	chr16	1772398	Silent	NA	S160S	0.42
READ	chr16	1772159	3'UTR	novel		0.38
SKCM	chr16	1772334	Missense_Mutation	NA	G182R	0.19
SKCM	chr16	1772441	Missense_Mutation	NA	E146V	0.22
SKCM	chr16	1772194	3'UTR	novel		0.21
UCEC	chr16	1772194	3'UTR	novel		0.3
UCEC	chr16	1772052	3'UTR	novel		0.18
UCEC	chr16	1772159	3'UTR	novel		0.45
UCEC	chr16	1772159	3'UTR	novel		0.44
UCEC	chr16	1772122	3'UTR	novel		0.34
UCEC	chr16	1771973	3'UTR	novel		1
UCEC	chr16	1772227	Frame_Shift_Del	NA	*V218Sfs?**	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.5556	0.22898
CHOL	DEL	0.1111	0.23475
LUAD	DEL	0.124	0.1886
UCS	DEL	0.4464	0.13407

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0022	Kaplan-Meier Survival Analysis
STAD	0.012	Kaplan-Meier Survival Analysis
MESO	0.023	Kaplan-Meier Survival Analysis
PCPG	0.04	Kaplan-Meier Survival Analysis
READ	0.041	Kaplan-Meier Survival Analysis
LAML	0.01	Kaplan-Meier Survival Analysis
LIHC	0.02	Kaplan-Meier Survival Analysis
CHOL	0.013	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis
OV	0.026	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000074071 (Gene tree)
Gene ID: 65993
Gene Symbol: MRPS34
Alias: MRP-S12|MGC2616
Full Name: mitochondrial ribosomal protein S34
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 1,266 bases
Position: chr16:1,771,890-1,773,155
Accession: 16618
RBP type: non-canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000397375	MRPS34-202	1024	-	ENSP00000380531	218 (aa)	-	P82930
ENST00000177742	MRPS34-201	1040	XM_017023595	ENSP00000177742	225 (aa)	XP_016879084	C9JJ19
ENST00000569585	MRPS34-203	713	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000074071's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000074071's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	28777931.	IMP	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005763	mitochondrial small ribosomal subunit	-	ISS	Component
GO:0032543	mitochondrial translation	28777931.	IMP	Process
GO:0032543	mitochondrial translation	-	ISS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.