EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
21724833Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'.Genes Dev2011 Jul 1Lin Gdoi: 10.1101/gad.2018911.
27210750Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer.Cell Rep2016 May 31Manteghi Sdoi: 10.1016/j.celrep.2016.04.076
23843459Tumor-suppressive function of protein-tyrosine phosphatase non-receptor type 23 in testicular germ cell tumors is lost upon overexpression of miR142-3p microRNA.J Biol Chem2013 Aug 16Tanaka Kdoi: 10.1074/jbc.M113.478891
19340315HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain.PLoS One2009Gingras MCdoi: 10.1371/journal.pone.0005105
28620046Role of ESCRT component HD-PTP/PTPN23 in cancer.Biochem Soc Trans2017 Jun 15Gingras MCdoi: 10.1042/BST20160332.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr347412153Missense_MutationnovelY1378C0.91
BLCAchr347408975SilentNAF510F0.21
BLCAchr347405054Missense_MutationNAE113K0.24
BLCAchr347406349Missense_MutationnovelE191Q0.1
BLCAchr347405962Silentrs772744440F154F0.23
BLCAchr347406553In_Frame_DelnovelQ234_W237del0.34
BRCAchr347411507Missense_Mutationrs755103681R1237C0.13
BRCAchr347407760Missense_MutationnovelI356T0.21
BRCAchr347409964SilentNAA722A0.24
BRCAchr347412513Splice_SitenovelX1440_splice0.15
BRCAchr347409278In_Frame_DelnovelA588_T593del0.19
BRCAchr347409476SilentNAN619N0.37
BRCAchr347411408Missense_MutationnovelH1204D0.32
BRCAchr347409692Missense_MutationNAE663K0.21
BRCAchr347412341Nonsense_MutationNAE1413*0.27
BRCAchr347409964SilentnovelA722A0.24
BRCAchr347409695Missense_MutationNAA664P0.52
BRCAchr347409054Missense_Mutationrs746807105R537W0.45
CESCchr347412564Silentrs756230136V1456V0.45
CESCchr347409709SilentNAL668L0.34
CESCchr3474132903'UTRnovel0.15
CESCchr3474132923'UTRnovel0.17
CESCchr347409024Missense_Mutationrs150002416R527C0.26
CESCchr347409836Splice_SitenovelX710_splice0.23
CESCchr347405936Missense_MutationNAH146Y0.34
CESCchr347408444SilentNAL428L0.57
COADchr347404683Missense_MutationNAG64D0.37
COADchr347409444Frame_Shift_DelnovelY609*0.31
COADchr347405928Missense_MutationNAS143F0.38
COADchr347404753SilentNAG87G0.36
COADchr3473810785'UTRnovel0.35
COADchr347410785Frame_Shift_DelNAY998Tfs*1620.34
COADchr347412943Nonsense_MutationNAQ1557*0.33
COADchr347410253Missense_MutationNAP819S0.35
COADchr347412805Frame_Shift_DelnovelL1513Wfs*710.44
COADchr347410325Missense_Mutationrs139305961V843M0.39
COADchr347411872Silentrs201197775T1326T0.23
COADchr347408994Missense_Mutationrs775291877R517C0.26
COADchr347411518Missense_MutationNAK1240N0.35
COADchr347409530Silentrs778078873Y637Y0.14
COADchr347410831Frame_Shift_Insrs770411657L1014Pfs*680.36
COADchr347412921SilentNAS1549S0.13
COADchr347396201Missense_MutationnovelL48P0.07
COADchr347408430Nonsense_MutationnovelK424*0.15
COADchr347410042Frame_Shift_DelNAP750Lfs*530.06
COADchr347411566Frame_Shift_DelnovelP1258Rfs*20.28
COADchr347411507Missense_Mutationrs755103681R1237C0.32
COADchr347410042Frame_Shift_DelNAP750Lfs*530.05
COADchr347413000Missense_MutationNAS1576P0.12
ESCAchr347408351Missense_MutationnovelF397L0.2
ESCAchr347413084Missense_MutationnovelN1604H0.23
ESCAchr347411305Missense_MutationnovelE1169D0.35
GBMchr347405030Missense_MutationnovelV105M0.21
GBMchr347405752Missense_MutationnovelA123G0.88
GBMchr347407328Missense_MutationnovelQ295P0.12
GBMchr347406365Missense_MutationnovelD196G0.48
HNSCchr347409428SilentnovelE603E0.07
HNSCchr347409173Silentrs141629698A551A0.31
HNSCchr347406603SilentnovelA250A0.26
HNSCchr347409505Missense_Mutationrs780485797A629V0.87
HNSCchr347410025Missense_MutationnovelE743K0.59
HNSCchr347411677Missense_MutationnovelE1293D0.13
KIRCchr347411320SilentNAL1174L0.4
KIRPchr347410827Missense_MutationnovelP1010R0.25
LAMLchr347409075Missense_MutationnovelA544T0.12
LGGchr347405947Nonsense_MutationNAC149*0.09
LGGchr347408937Missense_MutationnovelW498R0.36
LGGchr347409253Missense_Mutationrs754253770R578H0.3
LIHCchr347410566Missense_MutationNAT923I0.31
LIHCchr347410042Frame_Shift_DelNAP750Lfs*530.1
LIHCchr347407696Splice_SiteNAX335_splice0.59
LIHCchr3474133103'UTRnovel0.3
LIHCchr347411886Missense_Mutationrs754079072E1331V0.42
LUADchr347411141Missense_Mutationrs763104053A1115T0.22
LUADchr347412353Missense_Mutationrs773663848G1417R0.23
LUADchr347407767Silentrs781110452A358A0.15
LUADchr347409697Silentrs752849441A664A0.26
LUADchr347408796Missense_MutationNAD451N0.2
LUADchr347413104Missense_MutationnovelN1610K0.3
LUADchr347413105Missense_MutationnovelG1611W0.3
LUADchr347409540Missense_MutationnovelR641W0.28
LUADchr347405972SilentnovelR158R0.46
LUSCchr347411007Missense_Mutationrs762143288R1070Q0.16
LUSCchr347407931Missense_MutationnovelI387S0.17
LUSCchr347408435Silentrs775178936C425C0.58
OVchr347412295Frame_Shift_InsnovelR1398Cfs*540.11
OVchr347411565Frame_Shift_Insrs758419807L1259Afs*140.14
OVchr347408975SilentNAF510F0.27
OVchr347407185Missense_MutationnovelK288R0.14
PAADchr347411196Missense_MutationnovelS1133F0.23
PAADchr347408344Splice_SitenovelX395_splice0.15
PAADchr347410459SilentnovelI887I0.13
PAADchr347412960Silentrs371856828P1562P0.14
PAADchr347413027Missense_MutationnovelP1585T0.18
PRADchr347412594Missense_MutationnovelC1466W0.24
PRADchr347396145Splice_RegionnovelF29F0.1
PRADchr347408993Silentrs151244361H516H0.1
READchr347407761SilentNAI356I0.22
READchr347412146Missense_Mutationrs749890466A1376T0.24
READchr347411006Nonsense_Mutationrs767454205R1070*0.3
READchr347411198Missense_MutationNAP1134S0.58
SARCchr347409434Missense_MutationnovelQ605H0.07
SKCMchr347411345Missense_MutationNAG1183S0.31
SKCMchr347411476Silentrs763493430V1226V0.23
SKCMchr347413134In_Frame_DelnovelD1622del0.29
SKCMchr347412130SilentNAF1370F0.35
SKCMchr347413110Missense_MutationnovelQ1612H0.32
SKCMchr347411822Missense_MutationnovelP1310S0.66
SKCMchr347411823Missense_MutationnovelP1310L0.67
SKCMchr347407912Missense_MutationnovelR381W0.37
SKCMchr347407933Missense_MutationnovelE388K0.44
SKCMchr347408397Missense_MutationNAA413T0.46
SKCMchr347412166SilentNAR1382R0.29
SKCMchr347406382SilentNAL202L0.45
SKCMchr347412739Missense_MutationNAL1489F0.48
SKCMchr347410193Missense_MutationNAP799S0.54
SKCMchr347412168Missense_MutationNAP1383R0.23
STADchr347412300Missense_MutationNAT1399M0.37
STADchr347407333Missense_Mutationrs750641394A297T0.31
STADchr347411098Frame_Shift_DelNAP1102Qfs*580.39
STADchr347411141Missense_Mutationrs763104053A1115T0.25
STADchr347406012Missense_Mutationrs780215762R171H0.29
STADchr347411861Missense_Mutationrs778612238V1323I0.29
STADchr347410042Frame_Shift_DelNAP750Lfs*530.44
STADchr347412991Frame_Shift_InsnovelP1573Lfs*320.45
STADchr347405974SilentnovelR158R0.52
STADchr347410832Frame_Shift_DelNAL1014Yfs*1460.23
STADchr347410042Frame_Shift_DelNAP750Lfs*530.75
STADchr347412623In_Frame_Delrs766407272K1477del0.33
STADchr347408460Missense_MutationnovelT434A0.11
STADchr347409181Missense_MutationnovelQ554P0.11
STADchr347407556SilentnovelP325P0.23
STADchr347405785Missense_MutationNAR134Q0.19
STADchr347408456Silentrs756391820P432P0.17
STADchr347409060Missense_MutationNAA539T0.33
STADchr347409228Missense_Mutationrs765847614R570C0.08
STADchr347409557SilentNAD646D0.38
STADchr347412414In_Frame_Delrs760387665E1438del0.14
STADchr347409816Missense_MutationNAR704H0.25
STADchr347411098Frame_Shift_DelNAP1102Qfs*580.48
STADchr347406491Missense_MutationNAY213C0.09
STADchr347410318SilentnovelQ840Q0.24
STADchr347412402Missense_MutationNAK1433M0.34
STADchr347409192Missense_MutationNAR558C0.17
STADchr347408411SilentNAI417I0.26
STADchr347411796Missense_Mutationrs573090718R1301H0.07
STADchr347410832Frame_Shift_DelNAL1014Yfs*1460.11
STADchr347412126Missense_Mutationrs201950738R1369H0.18
STADchr347410832Frame_Shift_DelNAL1014Yfs*1460.46
STADchr347411166Missense_MutationnovelS1123I0.48
TGCTchr347409060Missense_MutationnovelA539P0.33
UCECchr347408924Missense_MutationNAE493D0.52
UCECchr347396188Nonsense_MutationNAE44*0.3
UCECchr347408932Missense_MutationNAR496Q0.35
UCECchr347409438Missense_MutationNAK607E0.26
UCECchr347396175Missense_MutationnovelE39D0.14
UCECchr347405766SilentnovelL128L0.43
UCECchr347408360SilentnovelS400S0.38
UCECchr347408826Missense_MutationnovelD461Y0.41
UCECchr347407149Missense_MutationnovelA276V0.11
UCECchr347412146Missense_Mutationrs749890466A1376T0.33
UCECchr347409024Missense_Mutationrs150002416R527C0.34
UCECchr347409299SilentnovelT593T0.34
UCECchr347396200Missense_MutationnovelL48M0.44
UCECchr347404698Missense_Mutationrs367969329R69H0.48
UCECchr347410094Missense_MutationnovelA766S0.33
UCECchr347405767Missense_MutationnovelL128R0.46
UCECchr347405957Missense_Mutationrs370113013A153T0.41
UCECchr347407340Missense_Mutationrs201653035R299H0.35
UCECchr347407935Missense_MutationNAE388D0.12
UCECchr347412974Missense_MutationNAA1567V0.18
UCECchr347406525Silentrs375545134P224P0.14
UCECchr347408785Missense_Mutationrs755297831G447D0.17
UCECchr347409816Missense_MutationNAR704H0.25
UCECchr347406732SilentNAQ263Q0.14
UCECchr347406597Silentrs371725325F248F0.36
UCECchr347408994Missense_Mutationrs775291877R517C0.26
UCECchr347409817SilentnovelR704R0.25
UCECchr347410283Missense_MutationnovelP829S0.21
UCECchr347411946Missense_Mutationrs770830112H1351R0.38
UCECchr347412819SilentnovelS1515S0.41
UCECchr347409248SilentnovelQ576Q0.35
UCECchr347406044Splice_RegionnovelL182L0.27
UCECchr347381124Missense_MutationnovelI10V0.31
UCECchr347409811SilentnovelA702A0.41
UCECchr347409075Missense_MutationnovelA544T0.53
UCECchr347409937Missense_MutationnovelK713N0.44
UCECchr347409438Frame_Shift_DelnovelK608Sfs*50.37
UCECchr347405997Missense_MutationnovelS166N0.08
UCECchr347412910Missense_Mutationrs538249359P1546T0.45
UCECchr347410495SilentnovelP899P0.22
UCECchr347407525In_Frame_DelnovelN316del0.44
UCECchr347412805Frame_Shift_DelnovelL1513Wfs*710.49
UCECchr347409543Missense_MutationnovelR642W0.42
UCECchr347411890Silentrs765250574R1332R0.39
UCECchr347411657Missense_MutationnovelM1287V0.14
UCECchr347412300Missense_MutationNAT1399M0.25
UCECchr347408435Silentrs775178936C425C0.44
UCECchr347409002Missense_MutationnovelM519I0.38
UCECchr347408358Missense_MutationnovelS400A0.09
UCECchr347412798Silentrs776628485R1508R0.42
UCECchr3474132053'UTRnovel0.41
UCECchr347410042Frame_Shift_DelNAP750Lfs*530.37
UCECchr347404763Missense_Mutationrs760010594A91T0.35
UCECchr347408436Missense_Mutationrs760349861A426T0.27
UCECchr347410042Frame_Shift_DelNAP750Lfs*530.08
UCECchr347410172Frame_Shift_DelnovelP793Lfs*100.36
UCECchr347413012SilentnovelL1580L0.31
UCECchr347410220Missense_MutationnovelP808T0.51
UCECchr347411222Nonsense_MutationnovelQ1142*0.42
UCECchr347407340Missense_Mutationrs201653035R299H0.36
UCECchr347411899SilentnovelS1335S0.52
UCECchr347405011Missense_MutationnovelE98D0.22
UCECchr347405947Silentrs747539038C149C0.67
UCECchr347407530Missense_Mutationrs768465983D317N0.47
UCECchr347409540Missense_MutationnovelR641W0.33
UCECchr347412125Missense_MutationNAR1369C0.23
UCECchr347412993SilentnovelP1573P0.67
UCECchr347409480Missense_MutationnovelA621T0.36
UCECchr347407160Missense_MutationnovelL280F0.28
UCECchr347409197SilentnovelI559I0.37
UCSchr347410067Nonsense_MutationnovelR757*0.18
UCSchr347410941Missense_MutationnovelP1048R0.46
UVMchr347412576SilentnovelH1460H0.8

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CHOLDEL0.80560.02241
DLBCDEL0.14580.016959
GBMDEL0.0780.056565
LGGDEL0.08580.00089193
LUADDEL0.33910.0021265
PAADDEL0.19020.030662
SARCDEL0.20230.0034746
SKCMDEL0.16350.13887
TGCTDEL0.20.08422
THYMDEL0.09760.037527

Survival Analysis
CancerP-value Q-value
SARC0.0017

Kaplan-Meier Survival Analysis

HNSC0.0023

Kaplan-Meier Survival Analysis

SKCM0.00085

Kaplan-Meier Survival Analysis

PRAD0.044

Kaplan-Meier Survival Analysis

BRCA0.0018

Kaplan-Meier Survival Analysis

KICH0.012

Kaplan-Meier Survival Analysis

LIHC0.0026

Kaplan-Meier Survival Analysis

LGG0.0017

Kaplan-Meier Survival Analysis

THCA0.04

Kaplan-Meier Survival Analysis

LUAD0.048

Kaplan-Meier Survival Analysis

UVM0.00023

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000076201 (Gene tree)
Gene ID
25930
Gene Symbol
PTPN23
Alias
DKFZP564F0923|KIAA1471|HD-PTP
Full Name
protein tyrosine phosphatase non-receptor type 23
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
32,460 bases
Position
chr3:47,380,982-47,413,441
Accession
14406
RBP type
non-canonical RBP
Summary
This gene encodes a member of the non-receptor type protein-tyrosine phosphatase family. The encoded protein may be involved in the regulation of small nuclear ribonucleo protein assembly and pre-mRNA splicing by modifying the survival motor neuron (SMN) complex. The encoded protein additionally plays a role in ciliogenesis and is part of endosomal sorting complex required for transport (ESCRT) pathways. This gene may serve a tumor suppressor function. [provided by RefSeq, Jul 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000456221PTPN23-202592-ENSP00000396328169 (aa)-C9JD91
ENST00000477276PTPN23-204882--- (aa)--
ENST00000495653PTPN23-205676--- (aa)--
ENST00000462998PTPN23-203260--- (aa)--
ENST00000602307PTPN23-2065119-ENSP0000047326664 (aa)-R4GMM7
ENST00000265562PTPN23-2015244XM_005265031ENSP000002655621636 (aa)XP_005265088Q9H3S7
Gene Model
Click here to download ENSG00000076201's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000076201rs6780013347410628GType 2 diabetes (adjusted for BMI)29632382[1.02-1.05]1.03EFO_0001360
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000076201's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004725protein tyrosine phosphatase activity21724833.IMPFunction
GO:0005515protein binding17174262.18434552.18835089.19523899.20936779.21179510.21724833.25416956.IPIFunction
GO:0005634nucleus21179510.IDAComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005737cytoplasm21179510.IDAComponent
GO:0005768endosome21179510.IDAComponent
GO:0005769early endosome21757351.IDAComponent
GO:0005829cytosol-IEAComponent
GO:0010633negative regulation of epithelial cell migration21724833.IMPProcess
GO:0015031protein transport-IEAProcess
GO:0016604nuclear body-IDAComponent
GO:0019901protein kinase binding21724833.IPIFunction
GO:0032456endocytic recycling24821423.IMPProcess
GO:0035335peptidyl-tyrosine dephosphorylation-IEAProcess
GO:0036064ciliary basal body20393563.IDAComponent
GO:0043162ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway21757351.IMPProcess
GO:0045022early endosome to late endosome transport24821423.IMPProcess
GO:0060271cilium assembly20393563.IMPProcess
GO:0061357positive regulation of Wnt protein secretion24821423.IMPProcess
GO:0070062extracellular exosome19056867.HDAComponent
GO:0071345cellular response to cytokine stimulus-TASProcess
GO:1903387positive regulation of homophilic cell adhesion21724833.IMPProcess
GO:1903393positive regulation of adherens junction organization21724833.IMPProcess
GO:2000643positive regulation of early endosome to late endosome transport21724833.IMPProcess
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