| 21129190 | Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition. | BMC Cancer | 2010 Dec 3 | Hackl C | doi: 10.1186/1471-2407-10-668. |
| 18820127 | 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1. | Mol Pharmacol | 2009 Jan | Tse AN | doi: 10.1124/mol.108.050807 |
| 14570880 | Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress. | J Biol Chem | 2003 Dec 26 | Arlander SJ | - |
| 15009113 | Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases. | Exp Dermatol | 2004 Jan | Becker B | - |
| 22268041 | The role of heat shock protein 90 in the regulation of tumor cell apoptosis. | Bull Exp Biol Med | 2011 Feb | Kaigorodova EV | - |
| 15613472 | Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy. | J Biol Chem | 2005 Feb 25 | M??ller P | - |
| 23638161 | High expression of heat shock protein 90 is associated with tumor aggressiveness and poor prognosis in patients with advanced gastric cancer. | PLoS One | 2013 Apr 26 | Wang J | doi: 10.1371/journal.pone.0062876 |
| 22975376 | Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. | Cancer Cell | 2012 Sep 11 | Chae YC | doi: 10.1016/j.ccr.2012.07.015. |
| 26271675 | HSP90 Inhibitor-SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors. | Mol Cancer Ther | 2015 Nov | Proia DA | doi: 10.1158/1535-7163.MCT-15-0455 |
| 17083915 | Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin. | Biochem Biophys Res Commun | 2006 Dec 22 | Noguchi M | - |
| 19965370 | The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy. | Proc Natl Acad Sci U S A | 2009 Dec 15 | Wang X | doi: 10.1073/pnas.0908151106 |
| 24384723 | HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer. | Cell Death Dis | 2014 Jan 2 | Schulz R | doi: 10.1038/cddis.2013.508. |
| 26334999 | Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors. | BMC Cancer | 2015 Sep 3 | Devarakonda CV | doi: 10.1186/s12885-015-1608-z. |
| 26782567 | Potential role of heat-shock proteins in giant cell tumors. | Genet Mol Res | 2015 Dec 29 | Chen JT | doi: 10.4238/2015.December.29.24. |
| 19855434 | Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth. | Oncogene | 2010 Jan 21 | Chandarlapaty S | doi: 10.1038/onc.2009.337 |
| 17299090 | Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. | Blood | 2007 Jun 1 | Spisek R | - |
| 24117238 | The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation. | Biochem J | 2014 Jan 1 | Lu XA | doi: 10.1042/BJ20130963. |
| 20553606 | Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation. | BMC Cancer | 2010 Jun 16 | McCready J | doi: 10.1186/1471-2407-10-294. |
| 22510516 | Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. | Breast Cancer Res | 2012 Apr 17 | Cheng Q | - |
| 27302312 | Value of serum human epididymis secretory protein 4 as a marker for differential diagnosis of malignant and benign gynecological diseases of patients in southern China. | Clin Chim Acta | 2016 Aug 1 | Li L | doi: 10.1016/j.cca.2016.06.010 |
| 25316816 | Plasma levels of heat shock protein 90 alpha associated with lung cancer development and treatment responses. | Clin Cancer Res | 2014 Dec 1 | Shi Y | doi: 10.1158/1078-0432.CCR-14-0174 |
| 17088927 | Mechanisms of disease: the role of heat-shock protein 90 in genitourinary malignancy. | Nat Clin Pract Urol | 2006 Nov | Lattouf JB | - |
| 29178343 | PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78. | Cancer Sci | 2018 Feb | Moriya C | doi: 10.1111/cas.13458 |
| 21369706 | Cell surface heat shock protein 90 modulates prostate cancer cell adhesion and invasion through the integrin-β1/focal adhesion kinase/c-Src signaling pathway. | Oncol Rep | 2011 May | Liu X | doi: 10.3892/or.2011.1202 |
| 22824801 | C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances. | Oncogene | 2013 Jun 20 | Muller P | doi: 10.1038/onc.2012.314 |
| 19569046 | Identification of novel hub genes associated with liver metastasis of gastric cancer. | Int J Cancer | 2009 Dec 15 | Chang W | doi: 10.1002/ijc.24699. |
| 21875325 | Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. | Nutr Cancer | 2011 | Li Y | doi: 10.1080/01635581.2011.596645 |
| 21478269 | Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. | Mol Cancer Res | 2011 May | Li D | doi: 10.1158/1541-7786.MCR-10-0534 |
| 25297628 | HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization. | Cancer Res | 2014 Dec 1 | Azoitei N | doi: 10.1158/0008-5472.CAN-14-1017 |
| 16774932 | Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. | Carcinogenesis | 2007 Jan | Park KA | - |
| 19635199 | [Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics]. | Ai Zheng | 2009 Jun | Zhang WL | - |
| 19576239 | Expression of Hsp90 chaperone [corrected] proteins in human tumor tissue. | Int J Biol Macromol | 2009 Oct 1 | McDowell CL | doi: 10.1016/j.ijbiomac.2009.06.012 |
| 22989880 | Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer. | J Biol Chem | 2012 Nov 2 | Hance MW | doi: 10.1074/jbc.M112.389015 |
| 18800240 | Expression of heat shock protein 90 at the cell surface in human neuroblastoma cells. | Cell Stress Chaperones | 2009 May | Cid C | doi: 10.1007/s12192-008-0076-7 |
| 22592212 | Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR-mutant lung cancer by decreasing client protein expression and angiogenesis. | J Thorac Oncol | 2012 Jul | Koizumi H | doi: 10.1097/JTO.0b013e3182519a2c. |
| 22849407 | Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells. | Biochem J | 2012 Oct 15 | Kang SA | - |
| 23065205 | HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study. | Mol Biol Rep | 2012 Dec | Zagouri F | doi: 10.1007/s11033-012-1984-2 |
| 24463348 | Heat shock protein 90 inhibitors in non-small-cell lung cancer. | Curr Opin Oncol | 2014 Mar | Pillai RN | doi: 10.1097/CCO.0000000000000047. |
| 18497978 | Molecular characterization of hsp90 isoforms in colorectal cancer cells and its association with tumour progression. | Int J Oncol | 2008 Jun | Milicevic Z | - |
| 23228483 | Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells. | Mol Oncol | 2013 Jun | Giordano C | doi: 10.1016/j.molonc.2012.11.002 |
| 18820283 | Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells. | Carcinogenesis | 2008 Dec | Kim RH | doi: 10.1093/carcin/bgn225 |
| 24736948 | Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-specic apoptosis. | Int J Oncol | 2014 Jul | Wang H | doi: 10.3892/ijo.2014.2388 |
| 22935698 | Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells. | Cell Cycle | 2012 Oct 1 | Iwai A | doi: 10.4161/cc.21926 |
| 24338924 | Extracellular Hsp90 mediates an NF-??B dependent inflammatory stromal program: implications for the prostate tumor microenvironment. | Prostate | 2014 Apr | Bohonowych JE | doi: 10.1002/pros.22761 |
| 21875461 | [FAK/c-Src signaling pathway mediates the expression of cell surface HSP90 in cultured human prostate cancer cells and its association with their invasive capability]. | Zhonghua Zhong Liu Za Zhi | 2011 May | Liu XG | - |
| 24952482 | Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells. | Oncotarget | 2014 Jul 15 | Tanimoto A | - |
| 26556859 | Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer. | Oncotarget | 2015 Nov 24 | Cavanaugh A | doi: 10.18632/oncotarget.5496. |
| 20558745 | Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression. | J Biol Chem | 2010 Aug 13 | Chen JS | doi: 10.1074/jbc.M110.139345 |
| 22912728 | Cell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasion. | PLoS One | 2012 | El Hamidieh A | doi: 10.1371/journal.pone.0042722 |
| 18320023 | Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. | PLoS One | 2008 Mar 5 | Gallegos Ruiz MI | doi: 10.1371/journal.pone.0001722. |
| 19142186 | Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin. | Br J Cancer | 2009 Jan 27 | Wu X | doi: 10.1038/sj.bjc.6604855 |
| 17975158 | Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth. | Clin Cancer Res | 2007 Nov 1 | Lang SA | - |
| 28038472 | Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity. | Oncotarget | 2017 Mar 21 | Nolan KD | doi: 10.18632/oncotarget.14252. |
| 28032595 | Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells. | Oncotarget | 2017 Jan 31 | Rouhi A | doi: 10.18632/oncotarget.13841. |
| 29888262 | HSP90: A Novel Target Gene of miRNA-628-3p in A549 Cells. | Biomed Res Int | 2018 May 20 | Pan J | doi: 10.1155/2018/4149707 |
