EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25658205Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.Mol Cell2015 Feb 5Kashatus JAdoi: 10.1016/j.molcel.2015.01.002.
25822260Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration.PLoS One2015 Mar 30Ferreira-da-Silva Adoi: 10.1371/journal.pone.0122308
28818497Drp1 regulates mitochondrial morphology and cell proliferation in cutaneous squamous cell carcinoma.J Dermatol Sci2017 DecKitamura Sdoi: 10.1016/j.jdermsci.2017.08.004
22487795Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells.Biochem Biophys Res Commun2012 Apr 27Inoue-Yamauchi Adoi: 10.1016/j.bbrc.2012.03.118
26114658A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission.Autophagy2015Zhou Jdoi: 10.1080/15548627.2015.1056970.
27746856Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment.Oxid Med Cell Longev2016Zou P-
25174275Mitochondrial division inhibitor-1 induces mitochondrial hyperfusion and sensitizes human cancer cells to TRAIL-induced apoptosis.Int J Oncol2014 NovAkita Mdoi: 10.3892/ijo.2014.2608
23028930Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model.PLoS One2012Thomas KJdoi: 10.1371/journal.pone.0045319
27509055Crosstalk between the mitochondrial fission protein, Drp1, and the cell cycle is identified across various cancer types and can impact survival of epithelial ovarian cancer patients.Oncotarget2016 Sep 13Tanwar DKdoi: 10.18632/oncotarget.11047.
29072687Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.Cell Death Dis2017 Oct 26Zhang Jdoi: 10.1038/cddis.2017.559.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1232708200Frame_Shift_Delrs779230636E116Kfs*60.47MMR_HSR1
BLCAchr1232720731Nonsense_MutationNAQ270*0.4
BLCAchr1232708200Frame_Shift_Delrs779230636E116Kfs*60.39MMR_HSR1
BLCAchr1232713252Missense_MutationnovelR167T0.47MMR_HSR1
BLCAchr1232731390Missense_MutationnovelS412L0.35
BLCAchr1232731353Splice_Regionnovel0.34
BRCAchr1232742641Nonsense_MutationNAQ683*0.39
CESCchr1232737866Missense_MutationNAS533F0.2
CESCchr1232731914Missense_Mutationrs747468677R473C0.11
CESCchr1232713259SilentNAL169L0.48
COADchr1232740221Missense_MutationNAA622V0.35
COADchr12327434273'UTRnovel0.29
COADchr1232738278Missense_MutationnovelS563R0.32
COADchr1232731061Missense_MutationnovelR376Q0.3
COADchr1232740440Missense_MutationnovelR639Q0.09
COADchr1232740127Nonsense_MutationnovelG591*0.26
COADchr12326793445'UTRnovel0.5
COADchr1232707400Missense_MutationNAH95R0.25MMR_HSR1
COADchr1232708183Nonsense_MutationNAE110*0.19MMR_HSR1
COADchr1232738285Nonsense_MutationNAE566*0.14
GBMchr12327448563'Flankrs7610666960.38
GBMchr12327435303'UTRnovel0.17
GBMchr1232737115Missense_Mutationrs756456130R517I0.37
HNSCchr12327448943'Flanknovel0.19
HNSCchr1232720728Missense_MutationnovelL269V0.15
HNSCchr1232733801Silentrs377443517N511N0.28
HNSCchr1232737869Missense_MutationnovelS534C0.19
KIRCchr1232733747SilentNAY493Y0.15
KIRCchr1232731500Nonsense_MutationnovelY449*0.22
KIRCchr1232710960Frame_Shift_DelNAS136Hfs*70.19MMR_HSR1
LGGchr1232718688Missense_Mutationrs754202457A222V0.39
LGGchr1232708200Frame_Shift_Delrs779230636E116Kfs*60.49MMR_HSR1
LIHCchr1232731022Frame_Shift_DelnovelG363Afs*90.27
LUADchr1232701524Missense_MutationnovelS71L0.07MMR_HSR1
LUADchr1232713267Missense_Mutationrs764915133R172Q0.19MMR_HSR1
LUADchr1232731911Missense_MutationnovelL472F0.38
LUADchr1232720710Frame_Shift_DelnovelR263Lfs*230.29
LUADchr1232731915Missense_MutationNAR473L0.18
LUADchr12326792375'Flanknovel1
LUADchr1232705846Intronnovel0.09
LUSCchr1232713208Splice_SitenovelX153_splice0.58
LUSCchr1232679373SilentnovelL4L0.58
LUSCchr1232718718Missense_MutationNAG232E0.28
LUSCchr12326793515'UTRnovel0.22
LUSCchr1232679432SilentnovelI23I0.16
LUSCchr1232705858Intronnovel0.29
LUSCchr1232740116Frame_Shift_DelnovelG587Efs*120.21
LUSCchr1232737130Missense_MutationnovelR522K0.18
OVchr12327449603'Flanknovel0.18
OVchr1232742748Missense_MutationnovelK718N0.06
OVchr1232731899Missense_MutationnovelV468L0.07
OVchr1232731463Missense_MutationnovelH436Q0.32
OVchr1232731472Missense_MutationNAM439I0.11
OVchr1232742734Missense_MutationnovelA714P0.09
OVchr12327446883'Flanknovel0.06
OVchr1232737942Missense_MutationnovelK558N0.13
PAADchr1232708181In_Frame_DelnovelE110del0.45MMR_HSR1
PAADchr1232731906Missense_MutationnovelC470Y0.18
PAADchr1232742698Nonsense_MutationnovelE702*0.08
PRADchr1232733776Missense_MutationNAD503V0.11
PRADchr1232718681Missense_MutationNAM220V0.04
PRADchr1232733726Missense_MutationnovelL486F0.09
PRADchr1232737129Nonsense_MutationnovelR522*0.06
PRADchr1232733807Splice_RegionnovelE513E0.45
READchr12327448453'Flanknovel0.37
SKCMchr1232710995Missense_MutationnovelD146N0.23MMR_HSR1
SKCMchr12326793315'UTRNA0.5
SKCMchr1232740091Missense_MutationNAD579N0.66
SKCMchr1232722543Missense_Mutationrs758981725S330N0.33
SKCMchr1232743363Frame_Shift_DelnovelG722Efs*260.32
SKCMchr1232713342Missense_MutationNAL197P0.15MMR_HSR1
SKCMchr1232740520Splice_SitenovelX665_splice0.51
SKCMchr1232731492Missense_MutationnovelC446Y0.57
SKCMchr1232718701SilentNAA226A0.63
STADchr1232731863Missense_MutationnovelR456G0.31
STADchr1232740440Missense_MutationnovelR639Q0.25
STADchr12327449863'Flanknovel0.12
STADchr1232731915Missense_MutationnovelR473H0.23
STADchr12327450803'Flanknovel0.16
STADchr12326793475'UTRrs7471156150.34
STADchr12327449493'Flankrs7708714280.33
STADchr1232737121Missense_MutationnovelR519M0.27
STADchr1232740516Splice_RegionNAD664D0.28
STADchr12327449493'Flankrs7708714280.53
UCECchr1232731363Missense_MutationNAR403H0.27
UCECchr12327447543'Flanknovel0.29
UCECchr1232738285Nonsense_MutationNAE566*0.33
UCECchr1232740207SilentnovelP617P0.39
UCECchr12327450063'Flanknovel0.64
UCECchr1232720796Splice_SiteNAX291_splice0.15
UCECchr1232731437Missense_MutationnovelS428C0.32
UCECchr12326792505'Flanknovel0.23
UCECchr12327448433'Flanknovel0.47
UCECchr1232701433Missense_MutationnovelV41M0.35MMR_HSR1
UCECchr1232731121Missense_MutationNAI396S0.3
UCECchr1232708205Missense_MutationnovelR117I0.16MMR_HSR1
UCECchr1232731477Missense_MutationnovelR441K0.17
UCECchr1232708178Missense_MutationNAR108Q0.17MMR_HSR1
UCECchr1232720778SilentNAL285L0.12
UCECchr1232701419Missense_MutationnovelS36N0.44MMR_HSR1
UCECchr1232707399Missense_MutationNAH95Y0.43MMR_HSR1
UCECchr12327434143'UTRnovel0.38
UCECchr12326792165'Flanknovel0.3
UCECchr1232701472Missense_MutationnovelG54C0.22MMR_HSR1
UCECchr1232733720SilentNAH484H0.39
UCECchr12327435903'UTRnovel0.5
UCECchr1232742669Missense_MutationnovelK692T0.38
UCECchr1232701485Missense_MutationnovelV58A0.31MMR_HSR1
UCECchr1232740214Missense_MutationnovelG620C0.42
UCECchr1232701553Nonsense_MutationnovelE81*0.39MMR_HSR1
UCECchr1232740169Nonsense_MutationnovelE605*0.57
UCECchr12327449393'Flanknovel0.42
UCECchr1232720736Missense_MutationnovelK271N0.4
UCECchr1232710949Silentrs370146907I130I0.27
UCECchr1232718645Missense_MutationnovelR208C0.28
UCECchr1232705842Intronnovel0.38
UCECchr1232737118Missense_MutationnovelN518I0.25
UCECchr1232740074Missense_MutationnovelG573E0.32
UCECchr12327449823'Flanknovel0.38
UCECchr1232742720Missense_Mutationrs776702636R709H0.34
UCECchr12326792585'Flanknovel0.05
UCECchr1232731050Missense_MutationnovelE372D0.41
UCECchr1232731864Missense_Mutationrs777512650R456Q0.32
UCECchr1232740427Missense_MutationnovelK635E0.12
UCECchr1232731069Nonsense_MutationNAE379*0.5
UCECchr1232713299Missense_Mutationrs751127554A183T0.24MMR_HSR1
UCECchr1232731028Missense_MutationnovelR365I0.32
UCECchr1232718713SilentnovelL230L0.13
UCECchr1232731443Missense_MutationnovelR430C0.38
UCECchr1232737157Missense_MutationnovelD531A0.16
UCECchr12327447703'Flanknovel0.08
UCECchr1232701439Missense_MutationnovelE43Q0.13MMR_HSR1
UCECchr1232705851IntronNA0.32
UCECchr1232720795Missense_MutationNAR291M0.1
UCECchr12327451043'Flanknovel0.13
UCECchr1232743354Missense_MutationnovelA719S0.33
UCSchr1232731513Splice_SitenovelX452_splice0.1

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
READDEL0.1030.064633

Survival Analysis
CancerP-value Q-value
KIRC0.00071

Kaplan-Meier Survival Analysis

MESO0.0031

Kaplan-Meier Survival Analysis

BRCA0.036

Kaplan-Meier Survival Analysis

KIRP0.013

Kaplan-Meier Survival Analysis

COAD0.028

Kaplan-Meier Survival Analysis

BLCA0.048

Kaplan-Meier Survival Analysis

READ0.024

Kaplan-Meier Survival Analysis

LIHC0.00013

Kaplan-Meier Survival Analysis

LUAD0.022

Kaplan-Meier Survival Analysis

OV0.037

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000087470 (Gene tree)
Gene ID
10059
Gene Symbol
DNM1L
Alias
DRP1|DVLP|HDYNIV|DYMPLE|VPS1
Full Name
dynamin 1 like
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
66,451 bases
Position
chr12:32,679,200-32,745,650
Accession
2973
RBP type
canonical RBP
Summary
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000447013MMR_HSR1PF01926.232.6e-0511
ENSP00000266481MMR_HSR1PF01926.236.4e-0511
ENSP00000415131MMR_HSR1PF01926.236.6e-0511
ENSP00000448610MMR_HSR1PF01926.237.2e-0511

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
31253394Loss of RNA binding protein, human antigen R enhances mitochondrial elongation by regulating Drp1 expression in SH-SY5Y cells.Biochem Biophys Res Commun2019 Aug 27Bae JEdoi: 10.1016/j.bbrc.2019.06.091
28230856Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1.Cell Death Dis2017 Feb 23Yang YLdoi: 10.1038/cddis.2017.43.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000547719DNM1L-214601--- (aa)--
ENST00000546757DNM1L-2092661-ENSP0000044810554 (aa)-H0YHY4
ENST00000549926DNM1L-221750--- (aa)--
ENST00000547640DNM1L-213602--- (aa)--
ENST00000549701DNM1L-2202487-ENSP00000450399736 (aa)-O00429
ENST00000551643DNM1L-227538-ENSP0000045040197 (aa)-F8VR28
ENST00000266481DNM1L-2013101XM_017018665ENSP00000266481699 (aa)XP_016874154O00429
ENST00000551076DNM1L-225556--- (aa)--
ENST00000548750DNM1L-218813-ENSP00000447788261 (aa)-F8VZ52
ENST00000548671DNM1L-217750--- (aa)--
ENST00000358214DNM1L-2023229-ENSP00000350948712 (aa)-G8JLD5
ENST00000414834DNM1L-2054211XM_011520544ENSP00000404160533 (aa)XP_011518846O00429
ENST00000550093DNM1L-223570--- (aa)--
ENST00000452533DNM1L-2074439-ENSP00000415131710 (aa)-O00429
ENST00000434676DNM1L-2061008-ENSP00000390090156 (aa)-B4DPZ9
ENST00000547078DNM1L-210450-ENSP0000044880248 (aa)-H0YI79
ENST00000552743DNM1L-228606--- (aa)--
ENST00000547548DNM1L-212724--- (aa)--
ENST00000548151DNM1L-216557--- (aa)--
ENST00000547932DNM1L-215417--- (aa)--
ENST00000550011DNM1L-222576--- (aa)--
ENST00000381000DNM1L-2034397-ENSP00000370388738 (aa)-O00429
ENST00000549157DNM1L-219556--- (aa)--
ENST00000546649DNM1L-2082097-ENSP00000448936117 (aa)-F8VYL3
ENST00000547312DNM1L-2112393-ENSP00000448610725 (aa)-O00429
ENST00000551476DNM1L-226560-ENSP00000447845172 (aa)-F8VUJ9
ENST00000553031DNM1L-229755--- (aa)--
ENST00000413295DNM1L-2041064-ENSP00000396030180 (aa)-B4DDQ3
ENST00000553257DNM1L-2302699XM_011520543ENSP00000449089749 (aa)XP_011518845O00429
ENST00000550154DNM1L-224550-ENSP00000447013168 (aa)-F8W1W3
Gene Model
Click here to download ENSG00000087470's gene model file
Pathways
Pathway IDPathway NameSource
hsa04217NecroptosisKEGG
hsa04621NOD-like receptor signaling pathwayKEGG
hsa04668TNF signaling pathwayKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000087470Hemoglobin A27.871e-005-
ENSG00000087470Platelet Function Tests4.6500000E-006-
ENSG00000087470Platelet Function Tests4.8500000E-006-
ENSG00000087470Platelet Function Tests2.1100000E-006-
ENSG00000087470Platelet Function Tests4.3700000E-006-
ENSG00000087470Platelet Function Tests5.0700000E-006-
ENSG00000087470Platelet Function Tests4.6500000E-006-
ENSG00000087470Platelet Function Tests4.6500000E-006-
ENSG00000087470Platelet Function Tests4.6500000E-006-
ENSG00000087470Platelet Function Tests1.0425700E-005-
ENSG00000087470Platelet Function Tests1.6024100E-005-
ENSG00000087470Platelet Function Tests2.3203200E-005-
ENSG00000087470Platelet Function Tests1.0425700E-005-
ENSG00000087470Platelet Function Tests1.0425700E-005-
ENSG00000087470Platelet Function Tests4.6500000E-006-
ENSG00000087470Platelet Function Tests1.6531600E-005-
ENSG00000087470Platelet Function Tests1.0547200E-005-
ENSG00000087470Platelet Function Tests1.2399400E-005-
ENSG00000087470Platelet Function Tests5.7000000E-006-
ENSG00000087470Platelet Function Tests1.2991100E-005-
ENSG00000087470Platelet Function Tests5.4105233E-006-
ENSG00000087470Platelet Function Tests1.8905200E-005-
ENSG00000087470Platelet Function Tests1.8905200E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000087470's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000087470DNM1L10087.286ENSAPOG00000022905-10087.286Acanthochromis_polyacanthus
ENSG00000087470DNM1L10087.692ENSAPOG00000016682dnm1l10087.395Acanthochromis_polyacanthus
ENSG00000087470DNM1L10087.518ENSACIG00000010115-10087.571Amphilophus_citrinellus
ENSG00000087470DNM1L10089.872ENSACIG00000002828dnm1l10089.444Amphilophus_citrinellus
ENSG00000087470DNM1L10087.429ENSAOCG00000005974-10087.429Amphiprion_ocellaris
ENSG00000087470DNM1L10088.604ENSAOCG00000010262dnm1l10088.302Amphiprion_ocellaris
ENSG00000087470DNM1L10087.552ENSAPEG00000005223dnm1l10087.255Amphiprion_percula
ENSG00000087470DNM1L10087.571ENSAPEG00000015504-10087.268Amphiprion_percula
ENSG00000087470DNM1L10087.268ENSATEG00000010274-10093.519Anabas_testudineus
ENSG00000087470DNM1L10087.732ENSATEG00000018248dnm1l10087.732Anabas_testudineus
ENSG00000087470DNM1L100100.000ENSANAG00000030575DNM1L100100.000Aotus_nancymaae
ENSG00000087470DNM1L10086.695ENSACLG00000001401dnm1l10086.695Astatotilapia_calliptera
ENSG00000087470DNM1L10087.429ENSACLG00000003008-10087.124Astatotilapia_calliptera
ENSG00000087470DNM1L10090.028ENSAMXG00000001473dnm1l10089.747Astyanax_mexicanus
ENSG00000087470DNM1L10094.158ENSBTAG00000011395DNM1L10094.158Bos_taurus
ENSG00000087470DNM1L10094.429ENSCHIG00000024000DNM1L10094.429Capra_hircus
ENSG00000087470DNM1L10099.859ENSCCAG00000031176DNM1L10099.859Cebus_capucinus
ENSG00000087470DNM1L100100.000ENSCATG00000016013DNM1L100100.000Cercocebus_atys
ENSG00000087470DNM1L10099.864ENSCANG00000040112DNM1L10099.864Colobus_angolensis_palliatus
ENSG00000087470DNM1L10086.409ENSCSEG00000011310DNM1L10086.123Cynoglossus_semilaevis
ENSG00000087470DNM1L9884.314ENSCSEG00000014488dnm1l9592.222Cynoglossus_semilaevis
ENSG00000087470DNM1L10086.695ENSCVAG00000011641-10086.552Cyprinodon_variegatus
ENSG00000087470DNM1L10086.467ENSCVAG00000021070dnm1l10086.838Cyprinodon_variegatus
ENSG00000087470DNM1L10090.129ENSDARG00000015006dnm1l10089.986Danio_rerio
ENSG00000087470DNM1L10087.268ENSELUG00000015446DNM1L10086.695Esox_lucius
ENSG00000087470DNM1L10087.360ENSELUG00000009177dnm1l10087.360Esox_lucius
ENSG00000087470DNM1L10086.143ENSFHEG00000009442-9592.593Fundulus_heteroclitus
ENSG00000087470DNM1L9883.007ENSGMOG00000001805-10081.960Gadus_morhua
ENSG00000087470DNM1L9886.928ENSGMOG00000001033dnm1l9983.911Gadus_morhua
ENSG00000087470DNM1L10086.099ENSGAFG00000000857dnm1l10086.448Gambusia_affinis
ENSG00000087470DNM1L10086.467ENSGAFG00000017056-10086.266Gambusia_affinis
ENSG00000087470DNM1L10086.286ENSGACG00000018930-10085.837Gasterosteus_aculeatus
ENSG00000087470DNM1L10085.813ENSGACG00000004145dnm1l9991.120Gasterosteus_aculeatus
ENSG00000087470DNM1L100100.000ENSGGOG00000006636DNM1L100100.000Gorilla_gorilla
ENSG00000087470DNM1L9888.235ENSHBUG00000004929-10080.544Haplochromis_burtoni
ENSG00000087470DNM1L10086.695ENSHBUG00000001952dnm1l10086.695Haplochromis_burtoni
ENSG00000087470DNM1L9889.003ENSIPUG00000006021dnm1l9789.003Ictalurus_punctatus
ENSG00000087470DNM1L10085.655ENSKMAG00000004994dnm1l10085.655Kryptolebias_marmoratus
ENSG00000087470DNM1L9886.928ENSKMAG00000021767-10084.276Kryptolebias_marmoratus
ENSG00000087470DNM1L9886.928ENSLBEG00000028335-9791.346Labrus_bergylta
ENSG00000087470DNM1L10087.255ENSLBEG00000008434dnm1l10087.115Labrus_bergylta
ENSG00000087470DNM1L10089.986ENSLACG00000009823DNM1L9887.832Latimeria_chalumnae
ENSG00000087470DNM1L10089.413ENSLOCG00000000949dnm1l10089.413Lepisosteus_oculatus
ENSG00000087470DNM1L100100.000ENSMFAG00000006058DNM1L100100.000Macaca_fascicularis
ENSG00000087470DNM1L100100.000ENSMMUG00000013655DNM1L100100.000Macaca_mulatta
ENSG00000087470DNM1L100100.000ENSMNEG00000037323DNM1L100100.000Macaca_nemestrina
ENSG00000087470DNM1L10087.133ENSMAMG00000023186dnm1l10086.975Mastacembelus_armatus
ENSG00000087470DNM1L10087.983ENSMAMG00000006659-10087.697Mastacembelus_armatus
ENSG00000087470DNM1L10087.589ENSMZEG00005007753dnm1l10087.589Maylandia_zebra
ENSG00000087470DNM1L9885.621ENSMMOG00000002489-10083.380Mola_mola
ENSG00000087470DNM1L9887.582ENSMMOG00000014588dnm1l10081.767Mola_mola
ENSG00000087470DNM1L10096.603ENSMODG00000012763DNM1L10096.603Monodelphis_domestica
ENSG00000087470DNM1L10084.835ENSMALG00000003988-10084.835Monopterus_albus
ENSG00000087470DNM1L10087.411ENSMALG00000011851dnm1l10087.268Monopterus_albus
ENSG00000087470DNM1L9898.039ENSMUSG00000022789Dnm1l9994.064Mus_musculus
ENSG00000087470DNM1L9888.235ENSNBRG00000000347-10083.192Neolamprologus_brichardi
ENSG00000087470DNM1L10087.589ENSNBRG00000020969dnm1l10087.589Neolamprologus_brichardi
ENSG00000087470DNM1L10085.793ENSONIG00000008672dnm1l10085.793Oreochromis_niloticus
ENSG00000087470DNM1L10084.480ENSONIG00000016752-9884.076Oreochromis_niloticus
ENSG00000087470DNM1L10085.307ENSORLG00000003624dnm1l10085.307Oryzias_latipes
ENSG00000087470DNM1L10086.286ENSORLG00000010705-10085.837Oryzias_latipes
ENSG00000087470DNM1L10082.336ENSORLG00020002127-9793.519Oryzias_latipes_hni
ENSG00000087470DNM1L10085.449ENSORLG00020016524dnm1l10085.449Oryzias_latipes_hni
ENSG00000087470DNM1L10085.592ENSORLG00015009298dnm1l10085.592Oryzias_latipes_hsok
ENSG00000087470DNM1L10084.298ENSORLG00015001039-9793.519Oryzias_latipes_hsok
ENSG00000087470DNM1L10085.294ENSOMEG00000010635dnm1l10085.294Oryzias_melastigma
ENSG00000087470DNM1L10086.695ENSOMEG00000013872-10086.409Oryzias_melastigma
ENSG00000087470DNM1L100100.000ENSPPAG00000039981DNM1L100100.000Pan_paniscus
ENSG00000087470DNM1L100100.000ENSPTRG00000004817DNM1L100100.000Pan_troglodytes
ENSG00000087470DNM1L10088.062ENSPKIG00000001634dnm1l10088.062Paramormyrops_kingsleyae
ENSG00000087470DNM1L9886.928ENSPKIG00000010643dnm1l9892.742Paramormyrops_kingsleyae
ENSG00000087470DNM1L9880.745ENSPMGG00000019068-8189.228Periophthalmus_magnuspinnatus
ENSG00000087470DNM1L10085.408ENSPMGG00000005630dnm1l10085.122Periophthalmus_magnuspinnatus
ENSG00000087470DNM1L10093.057ENSPCIG00000015246DNM1L10093.057Phascolarctos_cinereus
ENSG00000087470DNM1L9886.928ENSPFOG00000002801dnm1l10085.103Poecilia_formosa
ENSG00000087470DNM1L10087.429ENSPFOG00000012922-10087.124Poecilia_formosa
ENSG00000087470DNM1L10086.667ENSPLAG00000001690dnm1l10087.019Poecilia_latipinna
ENSG00000087470DNM1L10087.571ENSPLAG00000012587DNM1L10087.268Poecilia_latipinna
ENSG00000087470DNM1L10087.429ENSPMEG00000021909-10087.124Poecilia_mexicana
ENSG00000087470DNM1L10086.667ENSPMEG00000006603dnm1l10087.019Poecilia_mexicana
ENSG00000087470DNM1L10085.551ENSPREG00000009857-10085.122Poecilia_reticulata
ENSG00000087470DNM1L10086.383ENSPREG00000008602dnm1l10086.733Poecilia_reticulata
ENSG00000087470DNM1L10087.554ENSPNYG00000006979-10087.268Pundamilia_nyererei
ENSG00000087470DNM1L10088.301ENSPNAG00000020017dnm1l10088.000Pygocentrus_nattereri
ENSG00000087470DNM1L100100.000ENSRBIG00000035947DNM1L100100.000Rhinopithecus_bieti
ENSG00000087470DNM1L100100.000ENSRROG00000042126DNM1L100100.000Rhinopithecus_roxellana
ENSG00000087470DNM1L10099.718ENSSBOG00000026857DNM1L10099.718Saimiri_boliviensis_boliviensis
ENSG00000087470DNM1L9888.235ENSSFOG00015001002-10084.406Scleropages_formosus
ENSG00000087470DNM1L10089.270ENSSFOG00015004634dnm1l10088.841Scleropages_formosus
ENSG00000087470DNM1L10086.981ENSSMAG00000019922-10086.695Scophthalmus_maximus
ENSG00000087470DNM1L10085.734ENSSMAG00000008336dnm1l10085.434Scophthalmus_maximus
ENSG00000087470DNM1L10089.158ENSSDUG00000022859dnm1l10089.143Seriola_dumerili
ENSG00000087470DNM1L10087.714ENSSDUG00000008937-10087.268Seriola_dumerili
ENSG00000087470DNM1L10086.981ENSSLDG00000014797DNM1L10086.838Seriola_lalandi_dorsalis
ENSG00000087470DNM1L10087.857ENSSLDG00000006832-10087.411Seriola_lalandi_dorsalis
ENSG00000087470DNM1L10088.210ENSSPAG00000012049dnm1l10088.352Stegastes_partitus
ENSG00000087470DNM1L10086.838ENSSPAG00000015832-10086.838Stegastes_partitus
ENSG00000087470DNM1L10086.657ENSTRUG00000016834dnm1l10086.657Takifugu_rubripes
ENSG00000087470DNM1L10082.690ENSTNIG00000018526-10082.546Tetraodon_nigroviridis
ENSG00000087470DNM1L9892.810ENSXETG00000012252dnm1l10091.866Xenopus_tropicalis
ENSG00000087470DNM1L10087.714ENSXMAG00000011022-10087.411Xiphophorus_maculatus
ENSG00000087470DNM1L10085.794ENSXMAG00000017047dnm1l10085.714Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000139Golgi membrane-IEAComponent
GO:0000266mitochondrial fission21873635.IBAProcess
GO:0000266mitochondrial fission23530241.IDAProcess
GO:0000266mitochondrial fission23349293.23921378.26992161.27145208.IMPProcess
GO:0001836release of cytochrome c from mitochondria20850011.IMPProcess
GO:0003374dynamin family protein polymerization involved in mitochondrial fission21873635.IBAProcess
GO:0003374dynamin family protein polymerization involved in mitochondrial fission11514614.23530241.IDAProcess
GO:0003924GTPase activity21873635.IBAFunction
GO:0003924GTPase activity22265414.23530241.IDAFunction
GO:0005096GTPase activator activity25767741.ICFunction
GO:0005515protein binding9731200.12861026.18838687.19638400.21149567.21217774.21508961.21701560.22228096.22367970.22639965.23283981.23813973.24282027.24550280.26618722.27059175.IPIFunction
GO:0005525GTP binding-IEAFunction
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm12618434.21149567.23349293.IDAComponent
GO:0005737cytoplasm28969390.IMPComponent
GO:0005739mitochondrion11514614.22265414.23349293.23530241.23921378.24599962.26618722.29307555.IDAComponent
GO:0005739mitochondrion28969390.IMPComponent
GO:0005741mitochondrial outer membrane21149567.26122121.27145208.IDAComponent
GO:0005741mitochondrial outer membrane-TASComponent
GO:0005777peroxisome12618434.IDAComponent
GO:0005777peroxisome23921378.IMPComponent
GO:0005783endoplasmic reticulum9472031.IDAComponent
GO:0005783endoplasmic reticulum11514614.IDAComponent
GO:0005789endoplasmic reticulum membrane25767741.TASComponent
GO:0005794Golgi apparatus20688057.IDAComponent
GO:0005829cytosol22265414.23921378.IDAComponent
GO:0005829cytosol11514614.IMPComponent
GO:0005829cytosol-TASComponent
GO:0005874microtubule9472031.IDAComponent
GO:0005903brush border-IEAComponent
GO:0005905clathrin-coated pit-IEAComponent
GO:0006816calcium ion transport-IEAProcess
GO:0007005mitochondrion organization11514614.IMPProcess
GO:0007029endoplasmic reticulum organization11514614.IMPProcess
GO:0008017microtubule binding21873635.IBAFunction
GO:0008289lipid binding-IEAFunction
GO:0008637apoptotic mitochondrial changes21873635.IBAProcess
GO:0010468regulation of gene expression-IEAProcess
GO:0010637negative regulation of mitochondrial fusion-IEAProcess
GO:0010821regulation of mitochondrion organization21873635.IBAProcess
GO:0010821regulation of mitochondrion organization18353969.21149567.IMPProcess
GO:0016020membrane19946888.HDAComponent
GO:0016020membrane21873635.IBAComponent
GO:0016559peroxisome fission12618434.IDAProcess
GO:0016559peroxisome fission18353969.23921378.IMPProcess
GO:0017137Rab GTPase binding25767741.IDAFunction
GO:0030054cell junction-IEAComponent
GO:0030276clathrin binding-IEAFunction
GO:0030672synaptic vesicle membrane-IEAComponent
GO:0030742GTP-dependent protein binding25767741.IDAFunction
GO:0031625ubiquitin protein ligase binding16874301.19407830.IPIFunction
GO:0031966mitochondrial membrane21873635.IBAComponent
GO:0032459regulation of protein oligomerization20850011.IDAProcess
GO:0032991protein-containing complex17408615.IDAComponent
GO:0036466synaptic vesicle recycling via endosome-IEAProcess
GO:0042803protein homodimerization activity22265414.23530241.IDAFunction
GO:0043065positive regulation of apoptotic process20850011.IMPProcess
GO:0043231intracellular membrane-bounded organelle-IDAComponent
GO:0043547positive regulation of GTPase activity-IEAProcess
GO:0043653mitochondrial fragmentation involved in apoptotic process21873635.IBAProcess
GO:0043653mitochondrial fragmentation involved in apoptotic process12499352.18353969.21149567.IMPProcess
GO:0044877protein-containing complex binding-IEAFunction
GO:0048312intracellular distribution of mitochondria21873635.IBAProcess
GO:0048312intracellular distribution of mitochondria11514614.IMPProcess
GO:0048471perinuclear region of cytoplasm9472031.9570752.IDAComponent
GO:0048488synaptic vesicle endocytosis-IEAProcess
GO:0050714positive regulation of protein secretion9570752.IDAProcess
GO:0051259protein complex oligomerization27145208.IMPProcess
GO:0051289protein homotetramerization18353969.IDAProcess
GO:0051433BH2 domain binding-IEAFunction
GO:0060047heart contraction-IEAProcess
GO:0061003positive regulation of dendritic spine morphogenesis-IEAProcess
GO:0061025membrane fusion21873635.IBAProcess
GO:0061025membrane fusion20850011.IDAProcess
GO:0070266necroptotic process22265414.IMPProcess
GO:0070584mitochondrion morphogenesis21149567.IMPProcess
GO:0070585protein localization to mitochondrion-IEAProcess
GO:0090141positive regulation of mitochondrial fission19279012.IMPProcess
GO:0090141positive regulation of mitochondrial fission20436456.TASProcess
GO:0090149mitochondrial membrane fission11514614.IDAProcess
GO:0090149mitochondrial membrane fission27301544.27328748.IMPProcess
GO:0090200positive regulation of release of cytochrome c from mitochondria21149567.IMPProcess
GO:0090650cellular response to oxygen-glucose deprivation-IEAProcess
GO:0097194execution phase of apoptosis-TASProcess
GO:0098794postsynapse-IEAComponent
GO:0098835presynaptic endocytic zone membrane-IEAComponent
GO:0099073mitochondrion-derived vesicle26618722.IDAComponent
GO:1900063regulation of peroxisome organization18353969.IMPProcess
GO:1900244positive regulation of synaptic vesicle endocytosis-IEAProcess
GO:1903146regulation of autophagy of mitochondrion21873635.IBAProcess
GO:1903146regulation of autophagy of mitochondrion19279012.IGIProcess
GO:1903578regulation of ATP metabolic process-IEAProcess
GO:1904579cellular response to thapsigargin-IEAProcess
GO:1904666regulation of ubiquitin protein ligase activity-IEAProcess
GO:1905395response to flavonoid-IEAProcess
GO:1990910response to hypobaric hypoxia-IEAProcess
GO:2000302positive regulation of synaptic vesicle exocytosis-IEAProcess
GO:2001244positive regulation of intrinsic apoptotic signaling pathway20850011.IMPProcess
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