EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25658205	Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.	Mol Cell	2015 Feb 5	Kashatus JA	doi: 10.1016/j.molcel.2015.01.002.
25822260	Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration.	PLoS One	2015 Mar 30	Ferreira-da-Silva A	doi: 10.1371/journal.pone.0122308
28818497	Drp1 regulates mitochondrial morphology and cell proliferation in cutaneous squamous cell carcinoma.	J Dermatol Sci	2017 Dec	Kitamura S	doi: 10.1016/j.jdermsci.2017.08.004
22487795	Depletion of mitochondrial fission factor DRP1 causes increased apoptosis in human colon cancer cells.	Biochem Biophys Res Commun	2012 Apr 27	Inoue-Yamauchi A	doi: 10.1016/j.bbrc.2012.03.118
26114658	A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission.	Autophagy	2015	Zhou J	doi: 10.1080/15548627.2015.1056970.
27746856	Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment.	Oxid Med Cell Longev	2016	Zou P	-
25174275	Mitochondrial division inhibitor-1 induces mitochondrial hyperfusion and sensitizes human cancer cells to TRAIL-induced apoptosis.	Int J Oncol	2014 Nov	Akita M	doi: 10.3892/ijo.2014.2608
23028930	Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model.	PLoS One	2012	Thomas KJ	doi: 10.1371/journal.pone.0045319
27509055	Crosstalk between the mitochondrial fission protein, Drp1, and the cell cycle is identified across various cancer types and can impact survival of epithelial ovarian cancer patients.	Oncotarget	2016 Sep 13	Tanwar DK	doi: 10.18632/oncotarget.11047.
29072687	Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.	Cell Death Dis	2017 Oct 26	Zhang J	doi: 10.1038/cddis.2017.559.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr12	32708200	Frame_Shift_Del	rs779230636	*E116Kfs6**	0.47	MMR_HSR1
BLCA	chr12	32720731	Nonsense_Mutation	NA	Q270*	0.4
BLCA	chr12	32708200	Frame_Shift_Del	rs779230636	*E116Kfs6**	0.39	MMR_HSR1
BLCA	chr12	32713252	Missense_Mutation	novel	R167T	0.47	MMR_HSR1
BLCA	chr12	32731390	Missense_Mutation	novel	S412L	0.35
BLCA	chr12	32731353	Splice_Region	novel		0.34
BRCA	chr12	32742641	Nonsense_Mutation	NA	Q683*	0.39
CESC	chr12	32737866	Missense_Mutation	NA	S533F	0.2
CESC	chr12	32731914	Missense_Mutation	rs747468677	R473C	0.11
CESC	chr12	32713259	Silent	NA	L169L	0.48
COAD	chr12	32740221	Missense_Mutation	NA	A622V	0.35
COAD	chr12	32743427	3'UTR	novel		0.29
COAD	chr12	32738278	Missense_Mutation	novel	S563R	0.32
COAD	chr12	32731061	Missense_Mutation	novel	R376Q	0.3
COAD	chr12	32740440	Missense_Mutation	novel	R639Q	0.09
COAD	chr12	32740127	Nonsense_Mutation	novel	G591*	0.26
COAD	chr12	32679344	5'UTR	novel		0.5
COAD	chr12	32707400	Missense_Mutation	NA	H95R	0.25	MMR_HSR1
COAD	chr12	32708183	Nonsense_Mutation	NA	E110*	0.19	MMR_HSR1
COAD	chr12	32738285	Nonsense_Mutation	NA	E566*	0.14
GBM	chr12	32744856	3'Flank	rs761066696		0.38
GBM	chr12	32743530	3'UTR	novel		0.17
GBM	chr12	32737115	Missense_Mutation	rs756456130	R517I	0.37
HNSC	chr12	32744894	3'Flank	novel		0.19
HNSC	chr12	32720728	Missense_Mutation	novel	L269V	0.15
HNSC	chr12	32733801	Silent	rs377443517	N511N	0.28
HNSC	chr12	32737869	Missense_Mutation	novel	S534C	0.19
KIRC	chr12	32733747	Silent	NA	Y493Y	0.15
KIRC	chr12	32731500	Nonsense_Mutation	novel	Y449*	0.22
KIRC	chr12	32710960	Frame_Shift_Del	NA	*S136Hfs7**	0.19	MMR_HSR1
LGG	chr12	32718688	Missense_Mutation	rs754202457	A222V	0.39
LGG	chr12	32708200	Frame_Shift_Del	rs779230636	*E116Kfs6**	0.49	MMR_HSR1
LIHC	chr12	32731022	Frame_Shift_Del	novel	*G363Afs9**	0.27
LUAD	chr12	32701524	Missense_Mutation	novel	S71L	0.07	MMR_HSR1
LUAD	chr12	32713267	Missense_Mutation	rs764915133	R172Q	0.19	MMR_HSR1
LUAD	chr12	32731911	Missense_Mutation	novel	L472F	0.38
LUAD	chr12	32720710	Frame_Shift_Del	novel	*R263Lfs23**	0.29
LUAD	chr12	32731915	Missense_Mutation	NA	R473L	0.18
LUAD	chr12	32679237	5'Flank	novel		1
LUAD	chr12	32705846	Intron	novel		0.09
LUSC	chr12	32713208	Splice_Site	novel	X153_splice	0.58
LUSC	chr12	32679373	Silent	novel	L4L	0.58
LUSC	chr12	32718718	Missense_Mutation	NA	G232E	0.28
LUSC	chr12	32679351	5'UTR	novel		0.22
LUSC	chr12	32679432	Silent	novel	I23I	0.16
LUSC	chr12	32705858	Intron	novel		0.29
LUSC	chr12	32740116	Frame_Shift_Del	novel	*G587Efs12**	0.21
LUSC	chr12	32737130	Missense_Mutation	novel	R522K	0.18
OV	chr12	32744960	3'Flank	novel		0.18
OV	chr12	32742748	Missense_Mutation	novel	K718N	0.06
OV	chr12	32731899	Missense_Mutation	novel	V468L	0.07
OV	chr12	32731463	Missense_Mutation	novel	H436Q	0.32
OV	chr12	32731472	Missense_Mutation	NA	M439I	0.11
OV	chr12	32742734	Missense_Mutation	novel	A714P	0.09
OV	chr12	32744688	3'Flank	novel		0.06
OV	chr12	32737942	Missense_Mutation	novel	K558N	0.13
PAAD	chr12	32708181	In_Frame_Del	novel	E110del	0.45	MMR_HSR1
PAAD	chr12	32731906	Missense_Mutation	novel	C470Y	0.18
PAAD	chr12	32742698	Nonsense_Mutation	novel	E702*	0.08
PRAD	chr12	32733776	Missense_Mutation	NA	D503V	0.11
PRAD	chr12	32718681	Missense_Mutation	NA	M220V	0.04
PRAD	chr12	32733726	Missense_Mutation	novel	L486F	0.09
PRAD	chr12	32737129	Nonsense_Mutation	novel	R522*	0.06
PRAD	chr12	32733807	Splice_Region	novel	E513E	0.45
READ	chr12	32744845	3'Flank	novel		0.37
SKCM	chr12	32710995	Missense_Mutation	novel	D146N	0.23	MMR_HSR1
SKCM	chr12	32679331	5'UTR	NA		0.5
SKCM	chr12	32740091	Missense_Mutation	NA	D579N	0.66
SKCM	chr12	32722543	Missense_Mutation	rs758981725	S330N	0.33
SKCM	chr12	32743363	Frame_Shift_Del	novel	*G722Efs26**	0.32
SKCM	chr12	32713342	Missense_Mutation	NA	L197P	0.15	MMR_HSR1
SKCM	chr12	32740520	Splice_Site	novel	X665_splice	0.51
SKCM	chr12	32731492	Missense_Mutation	novel	C446Y	0.57
SKCM	chr12	32718701	Silent	NA	A226A	0.63
STAD	chr12	32731863	Missense_Mutation	novel	R456G	0.31
STAD	chr12	32740440	Missense_Mutation	novel	R639Q	0.25
STAD	chr12	32744986	3'Flank	novel		0.12
STAD	chr12	32731915	Missense_Mutation	novel	R473H	0.23
STAD	chr12	32745080	3'Flank	novel		0.16
STAD	chr12	32679347	5'UTR	rs747115615		0.34
STAD	chr12	32744949	3'Flank	rs770871428		0.33
STAD	chr12	32737121	Missense_Mutation	novel	R519M	0.27
STAD	chr12	32740516	Splice_Region	NA	D664D	0.28
STAD	chr12	32744949	3'Flank	rs770871428		0.53
UCEC	chr12	32731363	Missense_Mutation	NA	R403H	0.27
UCEC	chr12	32744754	3'Flank	novel		0.29
UCEC	chr12	32738285	Nonsense_Mutation	NA	E566*	0.33
UCEC	chr12	32740207	Silent	novel	P617P	0.39
UCEC	chr12	32745006	3'Flank	novel		0.64
UCEC	chr12	32720796	Splice_Site	NA	X291_splice	0.15
UCEC	chr12	32731437	Missense_Mutation	novel	S428C	0.32
UCEC	chr12	32679250	5'Flank	novel		0.23
UCEC	chr12	32744843	3'Flank	novel		0.47
UCEC	chr12	32701433	Missense_Mutation	novel	V41M	0.35	MMR_HSR1
UCEC	chr12	32731121	Missense_Mutation	NA	I396S	0.3
UCEC	chr12	32708205	Missense_Mutation	novel	R117I	0.16	MMR_HSR1
UCEC	chr12	32731477	Missense_Mutation	novel	R441K	0.17
UCEC	chr12	32708178	Missense_Mutation	NA	R108Q	0.17	MMR_HSR1
UCEC	chr12	32720778	Silent	NA	L285L	0.12
UCEC	chr12	32701419	Missense_Mutation	novel	S36N	0.44	MMR_HSR1
UCEC	chr12	32707399	Missense_Mutation	NA	H95Y	0.43	MMR_HSR1
UCEC	chr12	32743414	3'UTR	novel		0.38
UCEC	chr12	32679216	5'Flank	novel		0.3
UCEC	chr12	32701472	Missense_Mutation	novel	G54C	0.22	MMR_HSR1
UCEC	chr12	32733720	Silent	NA	H484H	0.39
UCEC	chr12	32743590	3'UTR	novel		0.5
UCEC	chr12	32742669	Missense_Mutation	novel	K692T	0.38
UCEC	chr12	32701485	Missense_Mutation	novel	V58A	0.31	MMR_HSR1
UCEC	chr12	32740214	Missense_Mutation	novel	G620C	0.42
UCEC	chr12	32701553	Nonsense_Mutation	novel	E81*	0.39	MMR_HSR1
UCEC	chr12	32740169	Nonsense_Mutation	novel	E605*	0.57
UCEC	chr12	32744939	3'Flank	novel		0.42
UCEC	chr12	32720736	Missense_Mutation	novel	K271N	0.4
UCEC	chr12	32710949	Silent	rs370146907	I130I	0.27
UCEC	chr12	32718645	Missense_Mutation	novel	R208C	0.28
UCEC	chr12	32705842	Intron	novel		0.38
UCEC	chr12	32737118	Missense_Mutation	novel	N518I	0.25
UCEC	chr12	32740074	Missense_Mutation	novel	G573E	0.32
UCEC	chr12	32744982	3'Flank	novel		0.38
UCEC	chr12	32742720	Missense_Mutation	rs776702636	R709H	0.34
UCEC	chr12	32679258	5'Flank	novel		0.05
UCEC	chr12	32731050	Missense_Mutation	novel	E372D	0.41
UCEC	chr12	32731864	Missense_Mutation	rs777512650	R456Q	0.32
UCEC	chr12	32740427	Missense_Mutation	novel	K635E	0.12
UCEC	chr12	32731069	Nonsense_Mutation	NA	E379*	0.5
UCEC	chr12	32713299	Missense_Mutation	rs751127554	A183T	0.24	MMR_HSR1
UCEC	chr12	32731028	Missense_Mutation	novel	R365I	0.32
UCEC	chr12	32718713	Silent	novel	L230L	0.13
UCEC	chr12	32731443	Missense_Mutation	novel	R430C	0.38
UCEC	chr12	32737157	Missense_Mutation	novel	D531A	0.16
UCEC	chr12	32744770	3'Flank	novel		0.08
UCEC	chr12	32701439	Missense_Mutation	novel	E43Q	0.13	MMR_HSR1
UCEC	chr12	32705851	Intron	NA		0.32
UCEC	chr12	32720795	Missense_Mutation	NA	R291M	0.1
UCEC	chr12	32745104	3'Flank	novel		0.13
UCEC	chr12	32743354	Missense_Mutation	novel	A719S	0.33
UCS	chr12	32731513	Splice_Site	novel	X452_splice	0.1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
READ	DEL	0.103	0.064633

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00071	Kaplan-Meier Survival Analysis
MESO	0.0031	Kaplan-Meier Survival Analysis
BRCA	0.036	Kaplan-Meier Survival Analysis
KIRP	0.013	Kaplan-Meier Survival Analysis
COAD	0.028	Kaplan-Meier Survival Analysis
BLCA	0.048	Kaplan-Meier Survival Analysis
READ	0.024	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
LUAD	0.022	Kaplan-Meier Survival Analysis
OV	0.037	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000087470 (Gene tree)
Gene ID: 10059
Gene Symbol: DNM1L
Alias: DRP1|DVLP|HDYNIV|DYMPLE|VPS1
Full Name: dynamin 1 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 66,451 bases
Position: chr12:32,679,200-32,745,650
Accession: 2973
RBP type: canonical RBP
Summary: This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000447013	MMR_HSR1	PF01926.23	2.6e-05	1	1
ENSP00000266481	MMR_HSR1	PF01926.23	6.4e-05	1	1
ENSP00000415131	MMR_HSR1	PF01926.23	6.6e-05	1	1
ENSP00000448610	MMR_HSR1	PF01926.23	7.2e-05	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31253394	Loss of RNA binding protein, human antigen R enhances mitochondrial elongation by regulating Drp1 expression in SH-SY5Y cells.	Biochem Biophys Res Commun	2019 Aug 27	Bae JE	doi: 10.1016/j.bbrc.2019.06.091
28230856	Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1.	Cell Death Dis	2017 Feb 23	Yang YL	doi: 10.1038/cddis.2017.43.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000547719	DNM1L-214	601	-	-	- (aa)	-	-
ENST00000546757	DNM1L-209	2661	-	ENSP00000448105	54 (aa)	-	H0YHY4
ENST00000549926	DNM1L-221	750	-	-	- (aa)	-	-
ENST00000547640	DNM1L-213	602	-	-	- (aa)	-	-
ENST00000549701	DNM1L-220	2487	-	ENSP00000450399	736 (aa)	-	O00429
ENST00000551643	DNM1L-227	538	-	ENSP00000450401	97 (aa)	-	F8VR28
ENST00000266481	DNM1L-201	3101	XM_017018665	ENSP00000266481	699 (aa)	XP_016874154	O00429
ENST00000551076	DNM1L-225	556	-	-	- (aa)	-	-
ENST00000548750	DNM1L-218	813	-	ENSP00000447788	261 (aa)	-	F8VZ52
ENST00000548671	DNM1L-217	750	-	-	- (aa)	-	-
ENST00000358214	DNM1L-202	3229	-	ENSP00000350948	712 (aa)	-	G8JLD5
ENST00000414834	DNM1L-205	4211	XM_011520544	ENSP00000404160	533 (aa)	XP_011518846	O00429
ENST00000550093	DNM1L-223	570	-	-	- (aa)	-	-
ENST00000452533	DNM1L-207	4439	-	ENSP00000415131	710 (aa)	-	O00429
ENST00000434676	DNM1L-206	1008	-	ENSP00000390090	156 (aa)	-	B4DPZ9
ENST00000547078	DNM1L-210	450	-	ENSP00000448802	48 (aa)	-	H0YI79
ENST00000552743	DNM1L-228	606	-	-	- (aa)	-	-
ENST00000547548	DNM1L-212	724	-	-	- (aa)	-	-
ENST00000548151	DNM1L-216	557	-	-	- (aa)	-	-
ENST00000547932	DNM1L-215	417	-	-	- (aa)	-	-
ENST00000550011	DNM1L-222	576	-	-	- (aa)	-	-
ENST00000381000	DNM1L-203	4397	-	ENSP00000370388	738 (aa)	-	O00429
ENST00000549157	DNM1L-219	556	-	-	- (aa)	-	-
ENST00000546649	DNM1L-208	2097	-	ENSP00000448936	117 (aa)	-	F8VYL3
ENST00000547312	DNM1L-211	2393	-	ENSP00000448610	725 (aa)	-	O00429
ENST00000551476	DNM1L-226	560	-	ENSP00000447845	172 (aa)	-	F8VUJ9
ENST00000553031	DNM1L-229	755	-	-	- (aa)	-	-
ENST00000413295	DNM1L-204	1064	-	ENSP00000396030	180 (aa)	-	B4DDQ3
ENST00000553257	DNM1L-230	2699	XM_011520543	ENSP00000449089	749 (aa)	XP_011518845	O00429
ENST00000550154	DNM1L-224	550	-	ENSP00000447013	168 (aa)	-	F8W1W3

Gene Model

Click here to download ENSG00000087470's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04217	Necroptosis	KEGG
hsa04621	NOD-like receptor signaling pathway	KEGG
hsa04668	TNF signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000087470	Hemoglobin A2	7.871e-005	-
ENSG00000087470	Platelet Function Tests	4.6500000E-006	-
ENSG00000087470	Platelet Function Tests	4.8500000E-006	-
ENSG00000087470	Platelet Function Tests	2.1100000E-006	-
ENSG00000087470	Platelet Function Tests	4.3700000E-006	-
ENSG00000087470	Platelet Function Tests	5.0700000E-006	-
ENSG00000087470	Platelet Function Tests	4.6500000E-006	-
ENSG00000087470	Platelet Function Tests	4.6500000E-006	-
ENSG00000087470	Platelet Function Tests	4.6500000E-006	-
ENSG00000087470	Platelet Function Tests	1.0425700E-005	-
ENSG00000087470	Platelet Function Tests	1.6024100E-005	-
ENSG00000087470	Platelet Function Tests	2.3203200E-005	-
ENSG00000087470	Platelet Function Tests	1.0425700E-005	-
ENSG00000087470	Platelet Function Tests	1.0425700E-005	-
ENSG00000087470	Platelet Function Tests	4.6500000E-006	-
ENSG00000087470	Platelet Function Tests	1.6531600E-005	-
ENSG00000087470	Platelet Function Tests	1.0547200E-005	-
ENSG00000087470	Platelet Function Tests	1.2399400E-005	-
ENSG00000087470	Platelet Function Tests	5.7000000E-006	-
ENSG00000087470	Platelet Function Tests	1.2991100E-005	-
ENSG00000087470	Platelet Function Tests	5.4105233E-006	-
ENSG00000087470	Platelet Function Tests	1.8905200E-005	-
ENSG00000087470	Platelet Function Tests	1.8905200E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000087470's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000087470	DNM1L	100	87.286	ENSAPOG00000022905	-	100	87.286	Acanthochromis_polyacanthus
ENSG00000087470	DNM1L	100	87.692	ENSAPOG00000016682	dnm1l	100	87.395	Acanthochromis_polyacanthus
ENSG00000087470	DNM1L	100	87.518	ENSACIG00000010115	-	100	87.571	Amphilophus_citrinellus
ENSG00000087470	DNM1L	100	89.872	ENSACIG00000002828	dnm1l	100	89.444	Amphilophus_citrinellus
ENSG00000087470	DNM1L	100	87.429	ENSAOCG00000005974	-	100	87.429	Amphiprion_ocellaris
ENSG00000087470	DNM1L	100	88.604	ENSAOCG00000010262	dnm1l	100	88.302	Amphiprion_ocellaris
ENSG00000087470	DNM1L	100	87.552	ENSAPEG00000005223	dnm1l	100	87.255	Amphiprion_percula
ENSG00000087470	DNM1L	100	87.571	ENSAPEG00000015504	-	100	87.268	Amphiprion_percula
ENSG00000087470	DNM1L	100	87.268	ENSATEG00000010274	-	100	93.519	Anabas_testudineus
ENSG00000087470	DNM1L	100	87.732	ENSATEG00000018248	dnm1l	100	87.732	Anabas_testudineus
ENSG00000087470	DNM1L	100	100.000	ENSANAG00000030575	DNM1L	100	100.000	Aotus_nancymaae
ENSG00000087470	DNM1L	100	86.695	ENSACLG00000001401	dnm1l	100	86.695	Astatotilapia_calliptera
ENSG00000087470	DNM1L	100	87.429	ENSACLG00000003008	-	100	87.124	Astatotilapia_calliptera
ENSG00000087470	DNM1L	100	90.028	ENSAMXG00000001473	dnm1l	100	89.747	Astyanax_mexicanus
ENSG00000087470	DNM1L	100	94.158	ENSBTAG00000011395	DNM1L	100	94.158	Bos_taurus
ENSG00000087470	DNM1L	100	94.429	ENSCHIG00000024000	DNM1L	100	94.429	Capra_hircus
ENSG00000087470	DNM1L	100	99.859	ENSCCAG00000031176	DNM1L	100	99.859	Cebus_capucinus
ENSG00000087470	DNM1L	100	100.000	ENSCATG00000016013	DNM1L	100	100.000	Cercocebus_atys
ENSG00000087470	DNM1L	100	99.864	ENSCANG00000040112	DNM1L	100	99.864	Colobus_angolensis_palliatus
ENSG00000087470	DNM1L	100	86.409	ENSCSEG00000011310	DNM1L	100	86.123	Cynoglossus_semilaevis
ENSG00000087470	DNM1L	98	84.314	ENSCSEG00000014488	dnm1l	95	92.222	Cynoglossus_semilaevis
ENSG00000087470	DNM1L	100	86.695	ENSCVAG00000011641	-	100	86.552	Cyprinodon_variegatus
ENSG00000087470	DNM1L	100	86.467	ENSCVAG00000021070	dnm1l	100	86.838	Cyprinodon_variegatus
ENSG00000087470	DNM1L	100	90.129	ENSDARG00000015006	dnm1l	100	89.986	Danio_rerio
ENSG00000087470	DNM1L	100	87.268	ENSELUG00000015446	DNM1L	100	86.695	Esox_lucius
ENSG00000087470	DNM1L	100	87.360	ENSELUG00000009177	dnm1l	100	87.360	Esox_lucius
ENSG00000087470	DNM1L	100	86.143	ENSFHEG00000009442	-	95	92.593	Fundulus_heteroclitus
ENSG00000087470	DNM1L	98	83.007	ENSGMOG00000001805	-	100	81.960	Gadus_morhua
ENSG00000087470	DNM1L	98	86.928	ENSGMOG00000001033	dnm1l	99	83.911	Gadus_morhua
ENSG00000087470	DNM1L	100	86.099	ENSGAFG00000000857	dnm1l	100	86.448	Gambusia_affinis
ENSG00000087470	DNM1L	100	86.467	ENSGAFG00000017056	-	100	86.266	Gambusia_affinis
ENSG00000087470	DNM1L	100	86.286	ENSGACG00000018930	-	100	85.837	Gasterosteus_aculeatus
ENSG00000087470	DNM1L	100	85.813	ENSGACG00000004145	dnm1l	99	91.120	Gasterosteus_aculeatus
ENSG00000087470	DNM1L	100	100.000	ENSGGOG00000006636	DNM1L	100	100.000	Gorilla_gorilla
ENSG00000087470	DNM1L	98	88.235	ENSHBUG00000004929	-	100	80.544	Haplochromis_burtoni
ENSG00000087470	DNM1L	100	86.695	ENSHBUG00000001952	dnm1l	100	86.695	Haplochromis_burtoni
ENSG00000087470	DNM1L	98	89.003	ENSIPUG00000006021	dnm1l	97	89.003	Ictalurus_punctatus
ENSG00000087470	DNM1L	100	85.655	ENSKMAG00000004994	dnm1l	100	85.655	Kryptolebias_marmoratus
ENSG00000087470	DNM1L	98	86.928	ENSKMAG00000021767	-	100	84.276	Kryptolebias_marmoratus
ENSG00000087470	DNM1L	98	86.928	ENSLBEG00000028335	-	97	91.346	Labrus_bergylta
ENSG00000087470	DNM1L	100	87.255	ENSLBEG00000008434	dnm1l	100	87.115	Labrus_bergylta
ENSG00000087470	DNM1L	100	89.986	ENSLACG00000009823	DNM1L	98	87.832	Latimeria_chalumnae
ENSG00000087470	DNM1L	100	89.413	ENSLOCG00000000949	dnm1l	100	89.413	Lepisosteus_oculatus
ENSG00000087470	DNM1L	100	100.000	ENSMFAG00000006058	DNM1L	100	100.000	Macaca_fascicularis
ENSG00000087470	DNM1L	100	100.000	ENSMMUG00000013655	DNM1L	100	100.000	Macaca_mulatta
ENSG00000087470	DNM1L	100	100.000	ENSMNEG00000037323	DNM1L	100	100.000	Macaca_nemestrina
ENSG00000087470	DNM1L	100	87.133	ENSMAMG00000023186	dnm1l	100	86.975	Mastacembelus_armatus
ENSG00000087470	DNM1L	100	87.983	ENSMAMG00000006659	-	100	87.697	Mastacembelus_armatus
ENSG00000087470	DNM1L	100	87.589	ENSMZEG00005007753	dnm1l	100	87.589	Maylandia_zebra
ENSG00000087470	DNM1L	98	85.621	ENSMMOG00000002489	-	100	83.380	Mola_mola
ENSG00000087470	DNM1L	98	87.582	ENSMMOG00000014588	dnm1l	100	81.767	Mola_mola
ENSG00000087470	DNM1L	100	96.603	ENSMODG00000012763	DNM1L	100	96.603	Monodelphis_domestica
ENSG00000087470	DNM1L	100	84.835	ENSMALG00000003988	-	100	84.835	Monopterus_albus
ENSG00000087470	DNM1L	100	87.411	ENSMALG00000011851	dnm1l	100	87.268	Monopterus_albus
ENSG00000087470	DNM1L	98	98.039	ENSMUSG00000022789	Dnm1l	99	94.064	Mus_musculus
ENSG00000087470	DNM1L	98	88.235	ENSNBRG00000000347	-	100	83.192	Neolamprologus_brichardi
ENSG00000087470	DNM1L	100	87.589	ENSNBRG00000020969	dnm1l	100	87.589	Neolamprologus_brichardi
ENSG00000087470	DNM1L	100	85.793	ENSONIG00000008672	dnm1l	100	85.793	Oreochromis_niloticus
ENSG00000087470	DNM1L	100	84.480	ENSONIG00000016752	-	98	84.076	Oreochromis_niloticus
ENSG00000087470	DNM1L	100	85.307	ENSORLG00000003624	dnm1l	100	85.307	Oryzias_latipes
ENSG00000087470	DNM1L	100	86.286	ENSORLG00000010705	-	100	85.837	Oryzias_latipes
ENSG00000087470	DNM1L	100	82.336	ENSORLG00020002127	-	97	93.519	Oryzias_latipes_hni
ENSG00000087470	DNM1L	100	85.449	ENSORLG00020016524	dnm1l	100	85.449	Oryzias_latipes_hni
ENSG00000087470	DNM1L	100	85.592	ENSORLG00015009298	dnm1l	100	85.592	Oryzias_latipes_hsok
ENSG00000087470	DNM1L	100	84.298	ENSORLG00015001039	-	97	93.519	Oryzias_latipes_hsok
ENSG00000087470	DNM1L	100	85.294	ENSOMEG00000010635	dnm1l	100	85.294	Oryzias_melastigma
ENSG00000087470	DNM1L	100	86.695	ENSOMEG00000013872	-	100	86.409	Oryzias_melastigma
ENSG00000087470	DNM1L	100	100.000	ENSPPAG00000039981	DNM1L	100	100.000	Pan_paniscus
ENSG00000087470	DNM1L	100	100.000	ENSPTRG00000004817	DNM1L	100	100.000	Pan_troglodytes
ENSG00000087470	DNM1L	100	88.062	ENSPKIG00000001634	dnm1l	100	88.062	Paramormyrops_kingsleyae
ENSG00000087470	DNM1L	98	86.928	ENSPKIG00000010643	dnm1l	98	92.742	Paramormyrops_kingsleyae
ENSG00000087470	DNM1L	98	80.745	ENSPMGG00000019068	-	81	89.228	Periophthalmus_magnuspinnatus
ENSG00000087470	DNM1L	100	85.408	ENSPMGG00000005630	dnm1l	100	85.122	Periophthalmus_magnuspinnatus
ENSG00000087470	DNM1L	100	93.057	ENSPCIG00000015246	DNM1L	100	93.057	Phascolarctos_cinereus
ENSG00000087470	DNM1L	98	86.928	ENSPFOG00000002801	dnm1l	100	85.103	Poecilia_formosa
ENSG00000087470	DNM1L	100	87.429	ENSPFOG00000012922	-	100	87.124	Poecilia_formosa
ENSG00000087470	DNM1L	100	86.667	ENSPLAG00000001690	dnm1l	100	87.019	Poecilia_latipinna
ENSG00000087470	DNM1L	100	87.571	ENSPLAG00000012587	DNM1L	100	87.268	Poecilia_latipinna
ENSG00000087470	DNM1L	100	87.429	ENSPMEG00000021909	-	100	87.124	Poecilia_mexicana
ENSG00000087470	DNM1L	100	86.667	ENSPMEG00000006603	dnm1l	100	87.019	Poecilia_mexicana
ENSG00000087470	DNM1L	100	85.551	ENSPREG00000009857	-	100	85.122	Poecilia_reticulata
ENSG00000087470	DNM1L	100	86.383	ENSPREG00000008602	dnm1l	100	86.733	Poecilia_reticulata
ENSG00000087470	DNM1L	100	87.554	ENSPNYG00000006979	-	100	87.268	Pundamilia_nyererei
ENSG00000087470	DNM1L	100	88.301	ENSPNAG00000020017	dnm1l	100	88.000	Pygocentrus_nattereri
ENSG00000087470	DNM1L	100	100.000	ENSRBIG00000035947	DNM1L	100	100.000	Rhinopithecus_bieti
ENSG00000087470	DNM1L	100	100.000	ENSRROG00000042126	DNM1L	100	100.000	Rhinopithecus_roxellana
ENSG00000087470	DNM1L	100	99.718	ENSSBOG00000026857	DNM1L	100	99.718	Saimiri_boliviensis_boliviensis
ENSG00000087470	DNM1L	98	88.235	ENSSFOG00015001002	-	100	84.406	Scleropages_formosus
ENSG00000087470	DNM1L	100	89.270	ENSSFOG00015004634	dnm1l	100	88.841	Scleropages_formosus
ENSG00000087470	DNM1L	100	86.981	ENSSMAG00000019922	-	100	86.695	Scophthalmus_maximus
ENSG00000087470	DNM1L	100	85.734	ENSSMAG00000008336	dnm1l	100	85.434	Scophthalmus_maximus
ENSG00000087470	DNM1L	100	89.158	ENSSDUG00000022859	dnm1l	100	89.143	Seriola_dumerili
ENSG00000087470	DNM1L	100	87.714	ENSSDUG00000008937	-	100	87.268	Seriola_dumerili
ENSG00000087470	DNM1L	100	86.981	ENSSLDG00000014797	DNM1L	100	86.838	Seriola_lalandi_dorsalis
ENSG00000087470	DNM1L	100	87.857	ENSSLDG00000006832	-	100	87.411	Seriola_lalandi_dorsalis
ENSG00000087470	DNM1L	100	88.210	ENSSPAG00000012049	dnm1l	100	88.352	Stegastes_partitus
ENSG00000087470	DNM1L	100	86.838	ENSSPAG00000015832	-	100	86.838	Stegastes_partitus
ENSG00000087470	DNM1L	100	86.657	ENSTRUG00000016834	dnm1l	100	86.657	Takifugu_rubripes
ENSG00000087470	DNM1L	100	82.690	ENSTNIG00000018526	-	100	82.546	Tetraodon_nigroviridis
ENSG00000087470	DNM1L	98	92.810	ENSXETG00000012252	dnm1l	100	91.866	Xenopus_tropicalis
ENSG00000087470	DNM1L	100	87.714	ENSXMAG00000011022	-	100	87.411	Xiphophorus_maculatus
ENSG00000087470	DNM1L	100	85.794	ENSXMAG00000017047	dnm1l	100	85.714	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0000266	mitochondrial fission	21873635.	IBA	Process
GO:0000266	mitochondrial fission	23530241.	IDA	Process
GO:0000266	mitochondrial fission	23349293.23921378.26992161.27145208.	IMP	Process
GO:0001836	release of cytochrome c from mitochondria	20850011.	IMP	Process
GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	21873635.	IBA	Process
GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	11514614.23530241.	IDA	Process
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	22265414.23530241.	IDA	Function
GO:0005096	GTPase activator activity	25767741.	IC	Function
GO:0005515	protein binding	9731200.12861026.18838687.19638400.21149567.21217774.21508961.21701560.22228096.22367970.22639965.23283981.23813973.24282027.24550280.26618722.27059175.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	12618434.21149567.23349293.	IDA	Component
GO:0005737	cytoplasm	28969390.	IMP	Component
GO:0005739	mitochondrion	11514614.22265414.23349293.23530241.23921378.24599962.26618722.29307555.	IDA	Component
GO:0005739	mitochondrion	28969390.	IMP	Component
GO:0005741	mitochondrial outer membrane	21149567.26122121.27145208.	IDA	Component
GO:0005741	mitochondrial outer membrane	-	TAS	Component
GO:0005777	peroxisome	12618434.	IDA	Component
GO:0005777	peroxisome	23921378.	IMP	Component
GO:0005783	endoplasmic reticulum	9472031.	IDA	Component
GO:0005783	endoplasmic reticulum	11514614.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	25767741.	TAS	Component
GO:0005794	Golgi apparatus	20688057.	IDA	Component
GO:0005829	cytosol	22265414.23921378.	IDA	Component
GO:0005829	cytosol	11514614.	IMP	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005874	microtubule	9472031.	IDA	Component
GO:0005903	brush border	-	IEA	Component
GO:0005905	clathrin-coated pit	-	IEA	Component
GO:0006816	calcium ion transport	-	IEA	Process
GO:0007005	mitochondrion organization	11514614.	IMP	Process
GO:0007029	endoplasmic reticulum organization	11514614.	IMP	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0008289	lipid binding	-	IEA	Function
GO:0008637	apoptotic mitochondrial changes	21873635.	IBA	Process
GO:0010468	regulation of gene expression	-	IEA	Process
GO:0010637	negative regulation of mitochondrial fusion	-	IEA	Process
GO:0010821	regulation of mitochondrion organization	21873635.	IBA	Process
GO:0010821	regulation of mitochondrion organization	18353969.21149567.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	21873635.	IBA	Component
GO:0016559	peroxisome fission	12618434.	IDA	Process
GO:0016559	peroxisome fission	18353969.23921378.	IMP	Process
GO:0017137	Rab GTPase binding	25767741.	IDA	Function
GO:0030054	cell junction	-	IEA	Component
GO:0030276	clathrin binding	-	IEA	Function
GO:0030672	synaptic vesicle membrane	-	IEA	Component
GO:0030742	GTP-dependent protein binding	25767741.	IDA	Function
GO:0031625	ubiquitin protein ligase binding	16874301.19407830.	IPI	Function
GO:0031966	mitochondrial membrane	21873635.	IBA	Component
GO:0032459	regulation of protein oligomerization	20850011.	IDA	Process
GO:0032991	protein-containing complex	17408615.	IDA	Component
GO:0036466	synaptic vesicle recycling via endosome	-	IEA	Process
GO:0042803	protein homodimerization activity	22265414.23530241.	IDA	Function
GO:0043065	positive regulation of apoptotic process	20850011.	IMP	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0043653	mitochondrial fragmentation involved in apoptotic process	21873635.	IBA	Process
GO:0043653	mitochondrial fragmentation involved in apoptotic process	12499352.18353969.21149567.	IMP	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0048312	intracellular distribution of mitochondria	21873635.	IBA	Process
GO:0048312	intracellular distribution of mitochondria	11514614.	IMP	Process
GO:0048471	perinuclear region of cytoplasm	9472031.9570752.	IDA	Component
GO:0048488	synaptic vesicle endocytosis	-	IEA	Process
GO:0050714	positive regulation of protein secretion	9570752.	IDA	Process
GO:0051259	protein complex oligomerization	27145208.	IMP	Process
GO:0051289	protein homotetramerization	18353969.	IDA	Process
GO:0051433	BH2 domain binding	-	IEA	Function
GO:0060047	heart contraction	-	IEA	Process
GO:0061003	positive regulation of dendritic spine morphogenesis	-	IEA	Process
GO:0061025	membrane fusion	21873635.	IBA	Process
GO:0061025	membrane fusion	20850011.	IDA	Process
GO:0070266	necroptotic process	22265414.	IMP	Process
GO:0070584	mitochondrion morphogenesis	21149567.	IMP	Process
GO:0070585	protein localization to mitochondrion	-	IEA	Process
GO:0090141	positive regulation of mitochondrial fission	19279012.	IMP	Process
GO:0090141	positive regulation of mitochondrial fission	20436456.	TAS	Process
GO:0090149	mitochondrial membrane fission	11514614.	IDA	Process
GO:0090149	mitochondrial membrane fission	27301544.27328748.	IMP	Process
GO:0090200	positive regulation of release of cytochrome c from mitochondria	21149567.	IMP	Process
GO:0090650	cellular response to oxygen-glucose deprivation	-	IEA	Process
GO:0097194	execution phase of apoptosis	-	TAS	Process
GO:0098794	postsynapse	-	IEA	Component
GO:0098835	presynaptic endocytic zone membrane	-	IEA	Component
GO:0099073	mitochondrion-derived vesicle	26618722.	IDA	Component
GO:1900063	regulation of peroxisome organization	18353969.	IMP	Process
GO:1900244	positive regulation of synaptic vesicle endocytosis	-	IEA	Process
GO:1903146	regulation of autophagy of mitochondrion	21873635.	IBA	Process
GO:1903146	regulation of autophagy of mitochondrion	19279012.	IGI	Process
GO:1903578	regulation of ATP metabolic process	-	IEA	Process
GO:1904579	cellular response to thapsigargin	-	IEA	Process
GO:1904666	regulation of ubiquitin protein ligase activity	-	IEA	Process
GO:1905395	response to flavonoid	-	IEA	Process
GO:1990910	response to hypobaric hypoxia	-	IEA	Process
GO:2000302	positive regulation of synaptic vesicle exocytosis	-	IEA	Process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	20850011.	IMP	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

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Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.