EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr3	16605309	5'UTR	rs563459082		0.51
BLCA	chr3	16594543	Missense_Mutation	NA	V204A	0.48
BLCA	chr3	16598592	Missense_Mutation	novel	A4T	0.17
BLCA	chr3	16592132	Missense_Mutation	novel	S251N	0.5
BLCA	chr3	16597033	Missense_Mutation	novel	G105S	0.1	RRM_1
BRCA	chr3	16605309	5'UTR	rs563459082		0.4
BRCA	chr3	16593671	Missense_Mutation	NA	G240E	0.77
CESC	chr3	16604585	Intron	novel		0.33
CESC	chr3	16593698	Nonsense_Mutation	NA	S231*	0.41
CESC	chr3	16587443	3'UTR	novel		0.35
CESC	chr3	16587603	3'UTR	novel		0.06
CESC	chr3	16587796	3'UTR	novel		0.39
CESC	chr3	16587892	3'UTR	novel		0.28
CESC	chr3	16592109	Missense_Mutation	NA	L259V	0.39
CHOL	chr3	16592129	Missense_Mutation	novel	I252T	0.05
COAD	chr3	16594534	Missense_Mutation	rs766124489	P207L	0.51
COAD	chr3	16605309	5'UTR	rs563459082		0.29
COAD	chr3	16597520	Frame_Shift_Del	NA	*F88Lfs9**	0.32	RRM_1
COAD	chr3	16605303	5'UTR	novel		0.39
COAD	chr3	16605362	5'UTR	novel		0.2
COAD	chr3	16605309	5'UTR	rs563459082		0.44
COAD	chr3	16597499	Missense_Mutation	novel	K95N	0.07	RRM_1
COAD	chr3	16605477	5'UTR	novel		0.71
COAD	chr3	16596798	Silent	NA	T150T	0.2
COAD	chr3	16597526	In_Frame_Ins	novel	S86_F87insKFG	0.03	RRM_1
ESCA	chr3	16587809	3'UTR	novel		0.11
ESCA	chr3	16587622	3'UTR	novel		0.48
GBM	chr3	16605363	5'UTR	novel		0.59
HNSC	chr3	16605224	5'UTR	novel		0.22
HNSC	chr3	16605328	5'UTR	novel		0.17
HNSC	chr3	16605292	5'UTR	novel		0.14
KIRC	chr3	16588602	3'UTR	novel		0.43
LIHC	chr3	16598450	Splice_Site	novel	X50_splice	0.49
LIHC	chr3	16597538	Silent	NA	Y82Y	0.34
LUAD	chr3	16598591	Missense_Mutation	NA	A4E	0.05
LUAD	chr3	16596839	Missense_Mutation	novel	P137S	0.11
LUSC	chr3	16594532	Splice_Site	NA	X207_splice	0.44
LUSC	chr3	16592117	Missense_Mutation	novel	V256A	0.15
LUSC	chr3	16594539	Silent	NA	V205V	0.41
LUSC	chr3	16605273	5'UTR	novel		0.37
PRAD	chr3	16605264	5'UTR	rs373749089		0.37
READ	chr3	16596993	Frame_Shift_Del	NA	*N118Ifs41**	0.39	RRM_1
READ	chr3	16588485	3'UTR	novel		0.14
READ	chr3	16598558	Missense_Mutation	novel	R15K	0.09
READ	chr3	16598556	Nonsense_Mutation	NA	E16*	0.55
READ	chr3	16605336	5'UTR	novel		0.68
SARC	chr3	16596889	Missense_Mutation	rs773266331	C120F	0.45	RRM_1
SARC	chr3	16604604	Intron	novel		0.18
SARC	chr3	16588570	3'UTR	novel		0.05
SKCM	chr3	16605349	5'UTR	novel		0.42
SKCM	chr3	16588657	3'UTR	novel		0.43
SKCM	chr3	16588578	3'UTR	novel		0.48
SKCM	chr3	16605339	5'UTR	novel		0.47
SKCM	chr3	16605372	5'UTR	novel		0.21
SKCM	chr3	16596777	Silent	novel	T157T	0.28
SKCM	chr3	16598504	Missense_Mutation	NA	P33L	0.45
SKCM	chr3	16592140	Silent	novel	V248V	0.29
SKCM	chr3	16593738	Missense_Mutation	NA	E218K	0.27
SKCM	chr3	16598127	Missense_Mutation	NA	E68K	0.42	RRM_1
SKCM	chr3	16593738	Missense_Mutation	NA	E218K	0.44
SKCM	chr3	16598127	Missense_Mutation	NA	E68K	0.38	RRM_1
SKCM	chr3	16592132	Missense_Mutation	novel	S251I	0.14
SKCM	chr3	16593671	Missense_Mutation	NA	G240E	0.53
SKCM	chr3	16592049	Splice_Site	NA	X278_splice	0.49
STAD	chr3	16596852	Silent	NA	N132N	0.32
STAD	chr3	16605214	5'UTR	novel		0.09
STAD	chr3	16605307	5'UTR	novel		0.1
STAD	chr3	16605354	5'UTR	novel		0.33
THCA	chr3	16605381	5'UTR	novel		0.15
UCEC	chr3	16598556	Nonsense_Mutation	NA	E16*	0.34
UCEC	chr3	16587979	3'UTR	novel		0.4
UCEC	chr3	16588305	3'UTR	novel		0.21
UCEC	chr3	16596754	Missense_Mutation	novel	V165A	0.05
UCEC	chr3	16588124	3'UTR	novel		0.44
UCEC	chr3	16588618	3'UTR	novel		0.34
UCEC	chr3	16594563	Silent	novel	V197V	0.25
UCEC	chr3	16588683	Missense_Mutation	NA	R289W	0.12
UCEC	chr3	16592050	Missense_Mutation	NA	K278N	0.21
UCEC	chr3	16598099	Missense_Mutation	novel	G77D	0.29	RRM_1
UCEC	chr3	16598106	Nonsense_Mutation	NA	R75*	0.45	RRM_1
UCEC	chr3	16587938	3'UTR	novel		0.24
UCEC	chr3	16587443	3'UTR	novel		0.14
UCEC	chr3	16594535	Missense_Mutation	novel	P207S	0.3
UCEC	chr3	16587631	3'UTR	novel		0.19
UCEC	chr3	16587892	3'UTR	novel		0.36
UCEC	chr3	16588232	3'UTR	novel		0.2
UCEC	chr3	16604498	Intron	novel		0.29
UCEC	chr3	16597495	Missense_Mutation	novel	V97I	0.34	RRM_1
UCEC	chr3	16588518	3'UTR	novel		0.25
UCEC	chr3	16596798	Silent	NA	T150T	0.12
UCEC	chr3	16605237	5'UTR	novel		0.36
UCEC	chr3	16588178	3'UTR	novel		0.39
UCEC	chr3	16588323	3'UTR	novel		0.58
UCEC	chr3	16588586	3'UTR	novel		0.41
UCEC	chr3	16605263	5'UTR	novel		0.34
UCEC	chr3	16587737	3'UTR	novel		0.45
UCEC	chr3	16587892	3'UTR	novel		0.41
UCEC	chr3	16588284	3'UTR	novel		0.24
UCEC	chr3	16597495	Missense_Mutation	novel	V97L	0.36	RRM_1
UCEC	chr3	16588475	3'UTR	novel		0.71
UCEC	chr3	16604530	Intron	rs775987625		0.45
UCEC	chr3	16588519	3'UTR	novel		0.25
UCEC	chr3	16587383	3'UTR	novel		0.6
UCEC	chr3	16588275	3'UTR	novel		0.32
UCEC	chr3	16587821	3'UTR	novel		0.1
UCEC	chr3	16598127	Nonsense_Mutation	novel	E68*	0.11	RRM_1
UCEC	chr3	16605278	5'UTR	novel		0.33
UCEC	chr3	16604443	Intron	novel		0.35
UCEC	chr3	16587783	3'UTR	novel		0.25
UCEC	chr3	16598088	Missense_Mutation	NA	G81R	0.19	RRM_1
UCEC	chr3	16596822	Silent	NA	V142V	0.35
UCEC	chr3	16605287	5'UTR	novel		0.19
UCEC	chr3	16605387	5'UTR	novel		0.17
UCEC	chr3	16588586	3'UTR	novel		0.4
UCEC	chr3	16593663	Missense_Mutation	NA	P243S	0.13
UCEC	chr3	16587455	3'UTR	novel		0.4
UCEC	chr3	16592135	Missense_Mutation	rs377332785	R250Q	0.33
UCEC	chr3	16587921	3'UTR	novel		0.33
UCEC	chr3	16588526	3'UTR	novel		0.3
UCEC	chr3	16595384	Missense_Mutation	novel	A167E	0.34
UCS	chr3	16592084	Missense_Mutation	NA	R267I	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.75	0.02241
COAD	DEL	0.122	0.010931
KIRC	DEL	0.8466	2.8873e-53
LUAD	DEL	0.314	0.068154
SKCM	DEL	0.158	0.13887
TGCT	DEL	0.2	0.08422
THYM	DEL	0.0894	0.037527

Survival Analysis

Cancer	P-value	Q-value
STAD	0.023	Kaplan-Meier Survival Analysis
MESO	0.025	Kaplan-Meier Survival Analysis
PRAD	0.045	Kaplan-Meier Survival Analysis
BRCA	0.028	Kaplan-Meier Survival Analysis
CESC	0.0088	Kaplan-Meier Survival Analysis
LUAD	0.014	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000092345 (Gene tree)
Gene ID: 1618
Gene Symbol: DAZL
Alias: DAZH|SPGYLA|MGC26406|DAZL1|DAZLA
Full Name: deleted in azoospermia like
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 83,515 bases
Position: chr3:16,586,792-16,670,306
Accession: 2685
RBP type: canonical RBP
Summary: The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000398109	RRM_1	PF00076.22	6.8e-14	1	1
ENSP00000382373	RRM_1	PF00076.22	1.2e-13	1	1
ENSP00000250863	RRM_1	PF00076.22	1.4e-13	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9143498	Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene.	Genomics	1997 Apr 15	Seboun E	-
15737929	The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway.	Dev Cell	2005 Mar	Costa A	-
19838299	DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish.	PLoS One	2009 Oct 19	Takeda Y	doi: 10.1371/journal.pone.0007513.
20332590	Temporal and spatial differential expression of chicken germline-specific proteins cDAZL, CDH and CVH during gametogenesis.	J Reprod Dev	2010 Jun	Kito G	-
24496621	Oocyte polarity requires a Bucky ball-dependent feedback amplification loop.	Development	2014 Feb	Heim AE	doi: 10.1242/dev.090449.
11804965	Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein.	Biol Reprod	2002 Feb	Jiao X	-
30380414	DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions.	Cell Rep	2018 Oct 30	Zagore LL	doi: 10.1016/j.celrep.2018.10.012.
21460039	Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.	Genes Dev	2011 Apr 1	Chen J	doi: 10.1101/gad.2028911.
24715697	The roles of DAZL in RNA biology and development.	Wiley Interdiscip Rev RNA	2014 Jul-Aug	Smorag L	doi: 10.1002/wrna.1228
9882490	Biphasic subcellular localization of the DAZL-related protein boule in Drosophila spermatogenesis.	Dev Biol	1998 Dec 15	Cheng MH	-
9588208	The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.	Biochem Biophys Res Commun	1998 Apr 28	Seligman J	-
8968755	A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.	Hum Mol Genet	1996 Dec	Shan Z	-
10393944	A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype.	Proc Natl Acad Sci U S A	1999 Jul 6	Slee R	-
11604102	Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.	BMC Genomics	2001	Dai T	-
16425031	Evolutionary comparison of the reproductive genes, DAZL and BOULE, in primates with and without DAZ.	Dev Genes Evol	2006 Mar	Tung JY	-
11514340	Nature of the spermatogenic arrest in Dazl -/- mice.	Biol Reprod	2001 Sep	Schrans-Stassen BH	-
11226060	Proliferation and differentiation of spermatogonial stem cells.	Reproduction	2001 Mar	de Rooij DG	-
11079458	Conservation of the deleted-in-azoospermia-like-1 (DAZL1) gene structure in old world monkeys points to a homologous function of DAZL1 in this primate class.	J Endocrinol Invest	2000 Oct	Grossmann B	-
10857750	Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.	Genomics	2000 May 1	Tsui S	-
16001084	The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells.	EMBO J	2005 Jul 20	Collier B	-
15705297	Role of the DAZ genes in male fertility.	Reprod Biomed Online	2005 Jan	Reynolds N	-
15607425	Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind.	Genomics	2005 Jan	Fox M	-
14611631	Absence of mDazl produces a final block on germ cell development at meiosis.	Reproduction	2003 Nov	Saunders PT	-
19783541	Dazl promotes germ cell differentiation from embryonic stem cells.	J Mol Cell Biol	2009 Dec	Yu Z	doi: 10.1093/jmcb/mjp026
19540345	Structure and RNA binding of the mouse Pumilio-2 Puf domain.	J Struct Biol	2009 Sep	Jenkins HT	doi: 10.1016/j.jsb.2009.06.007
19225045	The DAZL and PABP families: RNA-binding proteins with interrelated roles in translational control in oocytes.	Reproduction	2009 Apr	Brook M	doi: 10.1530/REP-08-0524
18452650	DAZL binds to the transcripts of several Tssk genes in germ cells.	BMB Rep	2008 Apr 30	Zeng M	-
17268180	Genomic structure and transcript variants of the bovine DAZL gene.	Cytogenet Genome Res	2007	Liu WS	-
22162380	Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro.	Stem Cells	2012 Mar	Medrano JV	doi: 10.1002/stem.1012.
22133614	Mitf is a transcriptional activator of medaka germ genes in culture.	Biochimie	2012 Mar	Zhao H	doi: 10.1016/j.biochi.2011.11.007
23298641	Mouse Dazl and its novel splice variant functions in translational repression of target mRNAs in embryonic stem cells.	Biochim Biophys Acta	2013 May	Xu X	doi: 10.1016/j.bbagrm.2012.12.010
21504946	Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells.	Proc Natl Acad Sci U S A	2011 May 3	Gill ME	doi: 10.1073/pnas.1104501108
20300286	A386G transition in DAZL gene is not associated with spermatogenic failure in Tamil Nadu, South India.	Indian J Hum Genet	2008 Jan	Poongothai J	doi: 10.4103/0971-6866.42322.
24467691	Exogenous retinoic acid and cytochrome P450 26B1 inhibitor modulate meiosis-associated genes expression in canine testis, an in vitro model.	Reprod Domest Anim	2014 Apr	Kasimanickam V	doi: 10.1111/rda.12276
24477583	Conservation and function of Dazl in promoting the meiosis of goat male germline stem cells.	Mol Biol Rep	2014 May	Niu Z	doi: 10.1007/s11033-014-3156-z
24086306	A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.	PLoS One	2013 Sep 25	He J	doi: 10.1371/journal.pone.0073996
26989066	Is there a role for DAZL in human female fertility?	Mol Hum Reprod	2016 Jun	Rosario R	doi: 10.1093/molehr/gaw024
27280388	Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis.	Mol Biol Cell	2016 Aug 1	Williams PA	doi: 10.1091/mbc.E15-11-0773
26030766	Epigenetic regulation of bovine spermatogenic cell-specific gene boule.	PLoS One	2015 Jun 1	Yao W	doi: 10.1371/journal.pone.0128250
25963278	Dynamic intracellular localization of Dazl protein during Xenopus germline development.	Histochem Cell Biol	2015 Aug	Tada H	doi: 10.1007/s00418-015-1323-5
25790371	GDF9 is transiently expressed in oocytes before follicle formation in the human fetal ovary and is regulated by a novel NOBOX transcript.	PLoS One	2015 Mar 19	Bayne RA	doi: 10.1371/journal.pone.0119819
28364521	RNA immunoprecipitation identifies novel targets of DAZL in human foetal ovary.	Mol Hum Reprod	2017 Mar 1	Rosario R	doi: 10.1093/molehr/gax004.
28604658	In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells.	Nat Commun	2017 Jun 12	Jung D	doi: 10.1038/ncomms15680.
28115159	DND protein functions as a translation repressor during zebrafish embryogenesis.	Biochem Biophys Res Commun	2017 Mar 4	Kobayashi M	doi: 10.1016/j.bbrc.2017.01.080
26595369	Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells.	Reprod Fertil Dev	2017 Apr	Shah SM	doi: 10.1071/RD15159.
10819768	Association of the mouse infertility factor DAZL1 with actively translating polyribosomes.	Biol Reprod	2000 Jun	Tsui S	-
22021443	Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.	Proc Natl Acad Sci U S A	2011 Nov 8	Jenkins HT	doi: 10.1073/pnas.1105211108

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000399444	DAZL-202	3050	-	ENSP00000382373	295 (aa)	-	Q92904
ENST00000250863	DAZL-201	3104	-	ENSP00000250863	315 (aa)	-	Q92904
ENST00000454457	DAZL-203	725	-	ENSP00000398109	204 (aa)	-	E7EV40

Gene Model

Click here to download ENSG00000092345's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000092345	Heart Rate	3.465e-005	-
ENSG00000092345	Lipoprotein(a)	6.0930000E-005	-
ENSG00000092345	Child Development Disorders, Pervasive	8.9005600E-006	-
ENSG00000092345	Child Development Disorders, Pervasive	1.0573300E-005	-
ENSG00000092345	Vitamin A	5.0450000E-005	-
ENSG00000092345	Erythrocyte Indices	9E-11	28017375
ENSG00000092345	Erythrocyte Indices	1E-6	28017375
ENSG00000092345	Schizophrenia	7E-6	26198764

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000092345	rs9869622	3	16630314	C	Lung cancer	28604730	[1.04-1.11]	1.0753014	EFO_0001071
ENSG00000092345	rs12494691	3	16658827	A	Response to opioid analgesics in cancer (pain decrease)	30277654	[NR] unit increase	0.01	EFO_0000311\|EFO_0008541

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000092345's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000092345	DAZL	81	85.455	ENSG00000205916	DAZ4	74	82.486
ENSG00000092345	DAZL	81	85.455	ENSG00000188120	DAZ1	86	82.584
ENSG00000092345	DAZL	81	85.455	ENSG00000205944	DAZ2	67	82.564
ENSG00000092345	DAZL	81	85.455	ENSG00000187191	DAZ3	76	82.564

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000092345	DAZL	69	36.052	ENSAMEG00000013712	BOLL	73	36.052	Ailuropoda_melanoleuca
ENSG00000092345	DAZL	99	91.837	ENSAMEG00000009059	-	100	91.525	Ailuropoda_melanoleuca
ENSG00000092345	DAZL	51	64.423	ENSACIG00000001931	dazl	66	51.389	Amphilophus_citrinellus
ENSG00000092345	DAZL	71	50.345	ENSAOCG00000019742	dazl	79	46.448	Amphiprion_ocellaris
ENSG00000092345	DAZL	71	50.345	ENSAPEG00000019114	dazl	74	48.718	Amphiprion_percula
ENSG00000092345	DAZL	75	50.633	ENSATEG00000001349	dazl	73	52.703	Anabas_testudineus
ENSG00000092345	DAZL	100	67.327	ENSAPLG00000007738	-	100	66.667	Anas_platyrhynchos
ENSG00000092345	DAZL	99	67.667	ENSACAG00000007822	-	88	70.330	Anolis_carolinensis
ENSG00000092345	DAZL	99	93.197	ENSANAG00000034405	DAZL	100	94.309	Aotus_nancymaae
ENSG00000092345	DAZL	71	52.778	ENSACLG00000000529	dazl	88	45.366	Astatotilapia_calliptera
ENSG00000092345	DAZL	66	43.256	ENSAMXG00000035291	dazl	89	43.689	Astyanax_mexicanus
ENSG00000092345	DAZL	69	36.481	ENSBTAG00000031614	BOLL	73	36.481	Bos_taurus
ENSG00000092345	DAZL	100	91.864	ENSBTAG00000000502	DAZL	100	91.864	Bos_taurus
ENSG00000092345	DAZL	100	94.595	ENSCJAG00000039120	DAZL	100	94.595	Callithrix_jacchus
ENSG00000092345	DAZL	85	32.857	ENSCAFG00000010947	BOLL	87	32.857	Canis_familiaris
ENSG00000092345	DAZL	100	92.881	ENSCAFG00000005867	-	100	92.881	Canis_familiaris
ENSG00000092345	DAZL	94	88.087	ENSCAFG00020027335	-	96	88.015	Canis_lupus_dingo
ENSG00000092345	DAZL	69	36.481	ENSCAFG00020004659	BOLL	73	36.481	Canis_lupus_dingo
ENSG00000092345	DAZL	100	92.542	ENSCHIG00000017877	DAZL	100	92.542	Capra_hircus
ENSG00000092345	DAZL	99	89.865	ENSTSYG00000000788	DAZL	100	89.865	Carlito_syrichta
ENSG00000092345	DAZL	85	32.857	ENSTSYG00000014204	BOLL	87	32.857	Carlito_syrichta
ENSG00000092345	DAZL	99	79.252	ENSCAPG00000003209	DAZL	98	86.154	Cavia_aperea
ENSG00000092345	DAZL	99	88.095	ENSCPOG00000007628	DAZL	99	88.095	Cavia_porcellus
ENSG00000092345	DAZL	100	94.932	ENSCCAG00000035747	DAZL	100	94.932	Cebus_capucinus
ENSG00000092345	DAZL	85	33.803	ENSCATG00000004430	BOLL	87	33.929	Cercocebus_atys
ENSG00000092345	DAZL	100	98.305	ENSCATG00000009078	DAZL	100	98.616	Cercocebus_atys
ENSG00000092345	DAZL	85	33.212	ENSCLAG00000017375	BOLL	91	33.212	Chinchilla_lanigera
ENSG00000092345	DAZL	99	88.737	ENSCLAG00000006407	DAZL	99	88.737	Chinchilla_lanigera
ENSG00000092345	DAZL	99	96.939	ENSCSAG00000009976	DAZL	100	96.610	Chlorocebus_sabaeus
ENSG00000092345	DAZL	81	81.928	ENSCSAG00000017742	-	52	78.125	Chlorocebus_sabaeus
ENSG00000092345	DAZL	99	81.973	ENSCHOG00000005264	-	100	81.973	Choloepus_hoffmanni
ENSG00000092345	DAZL	87	78.327	ENSCPBG00000022547	-	100	78.327	Chrysemys_picta_bellii
ENSG00000092345	DAZL	100	98.644	ENSCANG00000006852	DAZL	100	98.644	Colobus_angolensis_palliatus
ENSG00000092345	DAZL	99	90.816	ENSCGRG00001021961	Dazl	99	90.816	Cricetulus_griseus_chok1gshd
ENSG00000092345	DAZL	99	90.476	ENSCGRG00000013515	Dazl	98	90.476	Cricetulus_griseus_crigri
ENSG00000092345	DAZL	57	42.197	ENSCSEG00000014529	dazl	79	42.105	Cynoglossus_semilaevis
ENSG00000092345	DAZL	62	49.215	ENSDARG00000036214	dazl	84	49.457	Danio_rerio
ENSG00000092345	DAZL	99	91.216	ENSDNOG00000019085	-	100	91.246	Dasypus_novemcinctus
ENSG00000092345	DAZL	88	33.448	ENSDNOG00000017076	BOLL	78	33.448	Dasypus_novemcinctus
ENSG00000092345	DAZL	69	36.481	ENSDORG00000010791	Boll	77	36.481	Dipodomys_ordii
ENSG00000092345	DAZL	83	91.020	ENSDORG00000011497	Dazl	97	91.020	Dipodomys_ordii
ENSG00000092345	DAZL	98	93.056	ENSEASG00005005756	-	99	93.056	Equus_asinus_asinus
ENSG00000092345	DAZL	100	92.881	ENSECAG00000010923	-	100	92.881	Equus_caballus
ENSG00000092345	DAZL	99	79.932	ENSEEUG00000005973	-	100	79.932	Erinaceus_europaeus
ENSG00000092345	DAZL	57	55.833	ENSELUG00000006175	dazl	87	45.405	Esox_lucius
ENSG00000092345	DAZL	100	92.542	ENSFCAG00000023607	-	100	92.542	Felis_catus
ENSG00000092345	DAZL	83	59.921	ENSFALG00000008893	-	100	59.921	Ficedula_albicollis
ENSG00000092345	DAZL	98	88.542	ENSFDAG00000017861	DAZL	98	88.542	Fukomys_damarensis
ENSG00000092345	DAZL	85	33.704	ENSFDAG00000013036	BOLL	91	33.704	Fukomys_damarensis
ENSG00000092345	DAZL	53	34.524	ENSFHEG00000000765	-	57	34.524	Fundulus_heteroclitus
ENSG00000092345	DAZL	52	53.704	ENSGMOG00000011491	dazl	98	60.417	Gadus_morhua
ENSG00000092345	DAZL	99	68.121	ENSGALG00000011243	DAZL	99	66.443	Gallus_gallus
ENSG00000092345	DAZL	53	35.838	ENSGACG00000014439	-	58	35.838	Gasterosteus_aculeatus
ENSG00000092345	DAZL	74	48.701	ENSGACG00000007001	dazl	60	50.000	Gasterosteus_aculeatus
ENSG00000092345	DAZL	93	54.579	ENSGAGG00000017892	-	95	54.307	Gopherus_agassizii
ENSG00000092345	DAZL	100	100.000	ENSGGOG00000023632	DAZL	100	100.000	Gorilla_gorilla
ENSG00000092345	DAZL	71	53.472	ENSHBUG00000017426	dazl	88	45.854	Haplochromis_burtoni
ENSG00000092345	DAZL	85	32.210	ENSHGLG00000017562	BOLL	89	32.210	Heterocephalus_glaber_female
ENSG00000092345	DAZL	99	89.796	ENSHGLG00000013488	DAZL	99	89.796	Heterocephalus_glaber_female
ENSG00000092345	DAZL	99	89.796	ENSHGLG00100019389	DAZL	99	89.796	Heterocephalus_glaber_male
ENSG00000092345	DAZL	85	32.210	ENSHGLG00100015094	BOLL	91	32.210	Heterocephalus_glaber_male
ENSG00000092345	DAZL	50	63.725	ENSIPUG00000006376	dazl	86	44.103	Ictalurus_punctatus
ENSG00000092345	DAZL	99	91.156	ENSSTOG00000022122	-	99	91.156	Ictidomys_tridecemlineatus
ENSG00000092345	DAZL	85	33.214	ENSSTOG00000003536	BOLL	90	33.213	Ictidomys_tridecemlineatus
ENSG00000092345	DAZL	99	85.085	ENSJJAG00000010767	Dazl	100	85.424	Jaculus_jaculus
ENSG00000092345	DAZL	67	52.206	ENSKMAG00000019443	dazl	56	53.077	Kryptolebias_marmoratus
ENSG00000092345	DAZL	70	52.083	ENSLBEG00000006023	dazl	74	49.324	Labrus_bergylta
ENSG00000092345	DAZL	99	59.801	ENSLACG00000002895	-	100	59.801	Latimeria_chalumnae
ENSG00000092345	DAZL	86	32.292	ENSLACG00000015867	BOLL	76	32.292	Latimeria_chalumnae
ENSG00000092345	DAZL	87	47.872	ENSLOCG00000006452	dazl	85	48.624	Lepisosteus_oculatus
ENSG00000092345	DAZL	99	90.102	ENSLAFG00000009132	-	100	89.796	Loxodonta_africana
ENSG00000092345	DAZL	84	33.688	ENSMFAG00000030962	BOLL	90	33.451	Macaca_fascicularis
ENSG00000092345	DAZL	100	98.305	ENSMFAG00000002406	DAZL	100	98.305	Macaca_fascicularis
ENSG00000092345	DAZL	99	98.299	ENSMMUG00000011361	DAZL	100	98.299	Macaca_mulatta
ENSG00000092345	DAZL	100	90.000	ENSMMUG00000045289	-	84	90.000	Macaca_mulatta
ENSG00000092345	DAZL	84	33.333	ENSMMUG00000023811	BOLL	90	33.333	Macaca_mulatta
ENSG00000092345	DAZL	81	84.940	ENSMMUG00000041692	-	90	80.435	Macaca_mulatta
ENSG00000092345	DAZL	84	33.333	ENSMNEG00000033015	BOLL	90	33.333	Macaca_nemestrina
ENSG00000092345	DAZL	100	98.305	ENSMNEG00000038455	DAZL	100	98.305	Macaca_nemestrina
ENSG00000092345	DAZL	100	97.460	ENSMLEG00000038997	DAZL	100	97.460	Mandrillus_leucophaeus
ENSG00000092345	DAZL	85	33.803	ENSMLEG00000023905	BOLL	90	33.929	Mandrillus_leucophaeus
ENSG00000092345	DAZL	54	48.171	ENSMAMG00000008203	dazl	84	45.882	Mastacembelus_armatus
ENSG00000092345	DAZL	71	52.778	ENSMZEG00005009515	dazl	88	45.366	Maylandia_zebra
ENSG00000092345	DAZL	100	64.686	ENSMGAG00000010878	-	91	68.727	Meleagris_gallopavo
ENSG00000092345	DAZL	99	90.785	ENSMAUG00000018931	Dazl	96	90.785	Mesocricetus_auratus
ENSG00000092345	DAZL	100	92.230	ENSMICG00000049389	-	100	92.230	Microcebus_murinus
ENSG00000092345	DAZL	99	88.095	ENSMOCG00000016627	Dazl	99	88.095	Microtus_ochrogaster
ENSG00000092345	DAZL	50	49.669	ENSMMOG00000020238	dazl	65	50.345	Mola_mola
ENSG00000092345	DAZL	69	36.481	ENSMODG00000012323	BOLL	73	36.481	Monodelphis_domestica
ENSG00000092345	DAZL	100	86.532	ENSMODG00000014730	-	100	86.532	Monodelphis_domestica
ENSG00000092345	DAZL	68	53.957	ENSMALG00000021316	dazl	82	48.370	Monopterus_albus
ENSG00000092345	DAZL	99	88.095	MGP_CAROLIEiJ_G0021735	Dazl	98	89.883	Mus_caroli
ENSG00000092345	DAZL	99	88.435	ENSMUSG00000010592	Dazl	98	90.272	Mus_musculus
ENSG00000092345	DAZL	99	87.415	MGP_PahariEiJ_G0020724	Dazl	98	90.272	Mus_pahari
ENSG00000092345	DAZL	99	88.435	MGP_SPRETEiJ_G0022647	Dazl	99	88.435	Mus_spretus
ENSG00000092345	DAZL	99	92.568	ENSMPUG00000001426	-	100	92.256	Mustela_putorius_furo
ENSG00000092345	DAZL	99	89.492	ENSMLUG00000011337	-	100	89.189	Myotis_lucifugus
ENSG00000092345	DAZL	98	90.657	ENSNGAG00000009472	Dazl	99	90.657	Nannospalax_galili
ENSG00000092345	DAZL	67	54.015	ENSNBRG00000005425	dazl	57	57.724	Neolamprologus_brichardi
ENSG00000092345	DAZL	100	97.627	ENSNLEG00000033788	DAZL	100	97.627	Nomascus_leucogenys
ENSG00000092345	DAZL	99	70.307	ENSMEUG00000007283	-	99	70.307	Notamacropus_eugenii
ENSG00000092345	DAZL	99	82.993	ENSOPRG00000001387	-	99	80.831	Ochotona_princeps
ENSG00000092345	DAZL	99	86.395	ENSODEG00000006167	DAZL	99	86.395	Octodon_degus
ENSG00000092345	DAZL	71	50.694	ENSONIG00000004563	dazl	76	47.027	Oreochromis_niloticus
ENSG00000092345	DAZL	95	75.175	ENSOANG00000006742	-	82	78.652	Ornithorhynchus_anatinus
ENSG00000092345	DAZL	83	32.482	ENSOCUG00000013979	BOLL	86	32.482	Oryctolagus_cuniculus
ENSG00000092345	DAZL	99	90.136	ENSOCUG00000012635	-	100	89.831	Oryctolagus_cuniculus
ENSG00000092345	DAZL	67	51.079	ENSORLG00000004848	dazl	83	46.524	Oryzias_latipes
ENSG00000092345	DAZL	50	60.194	ENSORLG00020003976	dazl	79	45.989	Oryzias_latipes_hni
ENSG00000092345	DAZL	67	51.079	ENSORLG00015016143	dazl	89	42.180	Oryzias_latipes_hsok
ENSG00000092345	DAZL	67	51.799	ENSOMEG00000018395	dazl	63	51.825	Oryzias_melastigma
ENSG00000092345	DAZL	69	36.481	ENSOGAG00000007207	BOLL	73	36.481	Otolemur_garnettii
ENSG00000092345	DAZL	99	93.878	ENSOGAG00000006983	-	100	93.559	Otolemur_garnettii
ENSG00000092345	DAZL	87	93.023	ENSOARG00000015474	-	100	93.023	Ovis_aries
ENSG00000092345	DAZL	69	36.481	ENSOARG00000015644	BOLL	73	36.481	Ovis_aries
ENSG00000092345	DAZL	99	99.660	ENSPPAG00000037518	DAZL	100	99.660	Pan_paniscus
ENSG00000092345	DAZL	100	92.881	ENSPPRG00000008794	-	100	92.881	Panthera_pardus
ENSG00000092345	DAZL	100	92.881	ENSPTIG00000020895	-	100	92.881	Panthera_tigris_altaica
ENSG00000092345	DAZL	81	84.242	ENSPTRG00000023120	-	83	83.333	Pan_troglodytes
ENSG00000092345	DAZL	81	84.242	ENSPTRG00000028811	-	89	80.899	Pan_troglodytes
ENSG00000092345	DAZL	81	84.242	ENSPTRG00000050343	-	65	84.615	Pan_troglodytes
ENSG00000092345	DAZL	81	84.242	ENSPTRG00000047116	-	62	84.615	Pan_troglodytes
ENSG00000092345	DAZL	100	99.683	ENSPTRG00000014674	DAZL	100	99.683	Pan_troglodytes
ENSG00000092345	DAZL	100	98.305	ENSPANG00000015077	DAZL	100	98.305	Papio_anubis
ENSG00000092345	DAZL	99	75.585	ENSPSIG00000009803	-	92	74.582	Pelodiscus_sinensis
ENSG00000092345	DAZL	67	50.355	ENSPMGG00000006336	dazl	54	48.951	Periophthalmus_magnuspinnatus
ENSG00000092345	DAZL	57	91.379	ENSPEMG00000019679	Dazl	89	91.083	Peromyscus_maniculatus_bairdii
ENSG00000092345	DAZL	56	36.898	ENSPMAG00000009126	BOLL	58	39.444	Petromyzon_marinus
ENSG00000092345	DAZL	100	89.153	ENSPCIG00000028322	-	100	89.153	Phascolarctos_cinereus
ENSG00000092345	DAZL	100	97.966	ENSPPYG00000014080	DAZL	100	97.966	Pongo_abelii
ENSG00000092345	DAZL	85	33.099	ENSPPYG00000013050	BOLL	89	33.099	Pongo_abelii
ENSG00000092345	DAZL	99	87.075	ENSPCAG00000016182	-	100	87.075	Procavia_capensis
ENSG00000092345	DAZL	94	91.336	ENSPVAG00000007836	-	100	87.960	Pteropus_vampyrus
ENSG00000092345	DAZL	71	52.778	ENSPNYG00000020484	dazl	71	49.057	Pundamilia_nyererei
ENSG00000092345	DAZL	63	46.829	ENSPNAG00000012690	dazl	84	46.939	Pygocentrus_nattereri
ENSG00000092345	DAZL	99	88.435	ENSRNOG00000023474	Dazl	99	88.435	Rattus_norvegicus
ENSG00000092345	DAZL	99	95.578	ENSRBIG00000039636	DAZL	99	99.170	Rhinopithecus_bieti
ENSG00000092345	DAZL	100	98.644	ENSRROG00000036493	DAZL	100	98.962	Rhinopithecus_roxellana
ENSG00000092345	DAZL	100	94.257	ENSSBOG00000033845	DAZL	100	94.257	Saimiri_boliviensis_boliviensis
ENSG00000092345	DAZL	99	89.116	ENSSHAG00000005944	-	100	89.116	Sarcophilus_harrisii
ENSG00000092345	DAZL	69	36.481	ENSSHAG00000018057	BOLL	78	36.481	Sarcophilus_harrisii
ENSG00000092345	DAZL	75	53.205	ENSSFOG00015014199	dazl	82	52.151	Scleropages_formosus
ENSG00000092345	DAZL	68	49.640	ENSSMAG00000014694	dazl	55	50.382	Scophthalmus_maximus
ENSG00000092345	DAZL	51	60.952	ENSSDUG00000005172	dazl	85	47.337	Seriola_dumerili
ENSG00000092345	DAZL	51	60.952	ENSSLDG00000005485	dazl	85	47.337	Seriola_lalandi_dorsalis
ENSG00000092345	DAZL	99	89.456	ENSSARG00000008473	-	100	89.456	Sorex_araneus
ENSG00000092345	DAZL	96	74.048	ENSSPUG00000001799	-	93	75.092	Sphenodon_punctatus
ENSG00000092345	DAZL	75	47.436	ENSSPAG00000013741	dazl	73	48.993	Stegastes_partitus
ENSG00000092345	DAZL	99	92.517	ENSSSCG00000030671	-	100	92.203	Sus_scrofa
ENSG00000092345	DAZL	93	62.411	ENSTGUG00000003145	-	92	62.319	Taeniopygia_guttata
ENSG00000092345	DAZL	61	54.839	ENSTRUG00000015745	dazl	81	43.820	Takifugu_rubripes
ENSG00000092345	DAZL	99	88.776	ENSTBEG00000012225	-	99	87.540	Tupaia_belangeri
ENSG00000092345	DAZL	71	88.750	ENSTTRG00000012649	-	72	87.597	Tursiops_truncatus
ENSG00000092345	DAZL	91	92.884	ENSUAMG00000020299	-	95	92.884	Ursus_americanus
ENSG00000092345	DAZL	91	91.386	ENSUMAG00000018079	-	95	91.386	Ursus_maritimus
ENSG00000092345	DAZL	99	90.136	ENSVPAG00000000468	-	100	90.136	Vicugna_pacos
ENSG00000092345	DAZL	100	93.220	ENSVVUG00000000673	-	100	93.220	Vulpes_vulpes
ENSG00000092345	DAZL	69	36.481	ENSVVUG00000025901	BOLL	73	36.481	Vulpes_vulpes
ENSG00000092345	DAZL	92	53.986	ENSXETG00000025199	dazl	93	53.480	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	8968755.	TAS	Function
GO:0003730	mRNA 3'-UTR binding	21873635.	IBA	Function
GO:0005515	protein binding	10857750.16001084.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0007275	multicellular organism development	-	IEA	Process
GO:0007281	germ cell development	-	IEA	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0008494	translation activator activity	21873635.	IBA	Function
GO:0008494	translation activator activity	16001084.	IDA	Function
GO:0032991	protein-containing complex	10857750.	IDA	Component
GO:0045948	positive regulation of translational initiation	21873635.	IBA	Process
GO:0045948	positive regulation of translational initiation	16001084.	IDA	Process
GO:0070935	3'-UTR-mediated mRNA stabilization	21873635.	IBA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.