EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
29128633PHGDH is an independent prognosis marker and contributes cell proliferation, migration and invasion in human pancreatic cancer.Gene2018 Feb 5Song Zdoi: 10.1016/j.gene.2017.11.014
21804546Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.Nat Genet2011 Jul 31Locasale JWdoi: 10.1038/ng.890.
24247658Expression and clinical significance of phosphoglycerate dehydrogenase and squamous cell carcinoma antigen in cervical cancer.Int J Gynecol Cancer2013 OctJing Zdoi: 10.1097/IGC.0b013e3182a0c068.
21981974PHGDH amplification and altered glucose metabolism in human melanoma.Pigment Cell Melanoma Res2011 DecMullarky Edoi: 10.1111/j.1755-148X.2011.00919.x
26439504Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer.Oncology2015Yoon Sdoi: 10.1159/000439571
29626321LncRNA PlncRNA-1 overexpression inhibits the growth of breast cancer by upregulating TGF-β1 and downregulating PHGDH.Breast Cancer2018 SepLi Qdoi: 10.1007/s12282-018-0858-4

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr11197120215'UTRnovel0.67
BLCAchr1119721296Missense_MutationnovelT89A0.42
BLCAchr1119737114Missense_MutationnovelE265Q0.16
BLCAchr1119712055SilentNAI11I0.19
BLCAchr1119744025SilentnovelF529F0.24
BRCAchr11197441673'UTRnovel0.39
BRCAchr1119737263SilentnovelG314G0.33
BRCAchr1119721011Intronnovel0.29
BRCAchr11197441713'UTRnovel0.42
COADchr1119735305Frame_Shift_DelnovelN218Kfs*150.05
COADchr1119721070Intronnovel0.22
COADchr1119721070Intronnovel0.42
COADchr1119735340Missense_Mutationrs777155018R230H0.25
COADchr1119741850Missense_MutationnovelV388M0.29
COADchr1119712097Silentrs752195785D25D0.08
COADchr11197441153'UTRnovel0.38
COADchr1119721027Intronnovel0.29
COADchr1119737230Silentrs762185673F303F0.15
ESCAchr1119735340Missense_Mutationrs777155018R230H0.24
GBMchr1119734748Missense_MutationnovelL209I0.06
GBMchr1119742912Missense_MutationNAQ439E0.12
GBMchr1119721308Missense_MutationnovelI93F0.06
HNSCchr11197441013'UTRnovel0.25
HNSCchr11197119125'UTRnovel0.39
HNSCchr1119721113Intronnovel0.11
KIRCchr1119712025Translation_Start_SiteNAM1?0.34
LGGchr1119726886Missense_MutationnovelG131D0.06
LGGchr1119721284Missense_MutationnovelL85M0.37
LGGchr1119712025Translation_Start_SiteNAM1?0.3
LGGchr1119721276Missense_Mutationrs587625944N82S0.19
LIHCchr1119741851Missense_Mutationrs370627997V388A0.4
LIHCchr1119744025Missense_MutationnovelF529L0.42
LIHCchr1119723436SilentNAL117L0.41
LIHCchr1119741864Missense_MutationNAN392K0.35
LUADchr1119737194SilentnovelA291A0.14
LUADchr1119721256Missense_MutationNAR75S0.26
LUADchr1119741829Missense_MutationNAE381Q0.23
LUADchr1119737144Frame_Shift_InsnovelH275Qfs*20.28
LUADchr11197119645'UTRnovel0.38
LUADchr1119721268SilentNAG79G0.11
LUADchr1119742982Missense_MutationNAD462G0.21
LUADchr1119735334Missense_MutationnovelG228V0.15
LUADchr1119723441Missense_MutationNAR119M0.34
LUADchr1119742938SilentnovelG447G0.18
LUSCchr1119734729SilentnovelF202F0.47
LUSCchr1119742946Missense_MutationnovelG450E0.15
LUSCchr1119742866SilentnovelL423L0.14
LUSCchr1119735333Missense_MutationnovelG228R0.43
LUSCchr1119726866Silentrs146740411A124A0.19
LUSCchr1119737192Missense_MutationNAA291T0.42
LUSCchr1119735335Silentrs745471026G228G0.27
LUSCchr1119721192Missense_MutationNAR54P0.21
LUSCchr1119721220Silentrs372756781V63V0.34
OVchr1119743883Splice_Regionnovel0.26
OVchr1119740507Frame_Shift_DelnovelV356Gfs*20.07
OVchr1119726894Missense_Mutationrs139129607E134K0.07
OVchr1119741861SilentNAV391V0.39
OVchr1119743932SilentnovelS498S0.06
OVchr1119737211Missense_MutationnovelE297G0.08
PAADchr1119734654SilentnovelI177I0.09
PAADchr1119741805Missense_MutationNAA373T0.12
PRADchr1119726868Missense_Mutationrs764618040T125M0.19
SKCMchr1119721010Intronnovel0.64
SKCMchr1119740387Missense_MutationnovelV316G0.28
SKCMchr1119737166Missense_MutationNAP282L0.3
SKCMchr1119723423Missense_MutationNAM113T0.24
SKCMchr1119721201Missense_MutationnovelT57I0.12
SKCMchr1119734677Missense_MutationNAS185F0.37
SKCMchr1119737145Missense_MutationnovelH275L0.93
SKCMchr1119742898Missense_MutationNAA434D0.19
SKCMchr1119723377Frame_Shift_DelnovelT98Mfs*140.28
SKCMchr11197441243'UTRnovel0.27
SKCMchr11197440823'UTRnovel0.34
SKCMchr1119721215Missense_Mutationrs749449432D62N0.2
STADchr1119735390Missense_Mutationrs768347730R247W0.16
STADchr1119737205Missense_MutationNAC295Y0.3
STADchr1119721154Intronnovel0.34
STADchr1119721226Silentrs771208719N65N0.2
STADchr1119727038In_Frame_DelnovelL151_I156del0.27
STADchr1119735387Missense_MutationnovelL246I0.27
STADchr1119742916Missense_MutationnovelG440D0.32
STADchr1119741799Missense_MutationNAS371R0.31
STADchr1119721226Silentrs771208719N65N0.15
STADchr1119735441Nonsense_MutationnovelE264*0.33
STADchr1119735355Missense_MutationnovelA235V0.29
THYMchr1119721211Silentrs769991971T60T0.22
UCECchr1119735412Missense_MutationnovelC254Y0.3
UCECchr1119741816Silentrs199677303V376V0.49
UCECchr1119721152Intronnovel0.19
UCECchr11197119285'UTRnovel0.33
UCECchr1119726898Missense_Mutationrs774423823R135Q0.38
UCECchr1119712073SilentnovelP17P0.14
UCECchr1119742873Missense_MutationnovelA426S0.09
UCECchr1119721032Intronnovel0.35
UCECchr1119743971SilentNAI511I0.2
UCECchr1119734671Missense_Mutationrs376632509S183L0.06
UCECchr11197442093'UTRnovel0.42
UCECchr1119721293Missense_Mutationrs142988234A88T0.35
UCECchr1119726874Missense_Mutationrs746529669S127L0.43
UCECchr11197120185'UTRnovel0.41
UCECchr1119743966Missense_MutationnovelG510S0.24
UCECchr1119727080Missense_Mutationrs587777483R163Q0.35
UCECchr1119721164Splice_Regionnovel0.26
UCECchr1119737178Missense_MutationNAA286V0.36
UCECchr1119727048SilentnovelG152G0.4
UCECchr1119743908SilentNAV490V0.42
UCECchr1119712124Missense_MutationnovelQ34H0.28
UCECchr1119743973Missense_MutationnovelS512F0.15
UCECchr1119721292Silentrs761309245A87A0.13
UCECchr1119721155Intronnovel0.31
UCECchr1119741819SilentnovelG377G0.41
UCECchr1119737230Silentrs762185673F303F0.24
UCECchr1119743888Missense_Mutationrs200693896L484F0.32
UCECchr1119734748Missense_MutationnovelL209I0.32
UCECchr1119735415Missense_MutationnovelA255V0.4
UCECchr11197119595'UTRnovel0.17
UCECchr1119712149Missense_MutationNAA43S0.29
UCECchr1119721293Missense_Mutationrs142988234A88T0.45
UCECchr1119743997Missense_Mutationrs151275800A520V0.34
UCECchr1119734640Missense_MutationnovelG173W0.48
UCECchr1119742893SilentnovelY432Y0.13

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.06440.01281
COADDEL0.1840.00038973
DLBCDEL0.08330.0017831
HNSCDEL0.19927.836e-19
LUADDEL0.18992.5961e-13
PAADAMP0.08156.2379e-05
SKCMAMP0.26437.9957e-12
STADDEL0.12930.0040659
TGCTAMP0.220.088103

Survival Analysis
CancerP-value Q-value
MESO0.05

Kaplan-Meier Survival Analysis

ACC0.00012

Kaplan-Meier Survival Analysis

LUSC0.045

Kaplan-Meier Survival Analysis

KIRP0.00039

Kaplan-Meier Survival Analysis

COAD0.016

Kaplan-Meier Survival Analysis

PAAD0.043

Kaplan-Meier Survival Analysis

PCPG0.02

Kaplan-Meier Survival Analysis

BLCA0.0016

Kaplan-Meier Survival Analysis

LAML0.036

Kaplan-Meier Survival Analysis

KICH0.0057

Kaplan-Meier Survival Analysis

UCEC0.00012

Kaplan-Meier Survival Analysis

GBM0.0019

Kaplan-Meier Survival Analysis

LGG0.025

Kaplan-Meier Survival Analysis

OV0.016

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000092621 (Gene tree)
Gene ID
26227
Gene Symbol
PHGDH
Alias
SERA|PGDH|PDG
Full Name
phosphoglycerate dehydrogenase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
95,816 bases
Position
chr1:119,648,411-119,744,226
Accession
8923
RBP type
non-canonical RBP
Summary
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
28900157Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms.Sci Rep2017 Sep 12Wu Wdoi: 10.1038/s41598-017-11018-1.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000641756PHGDH-2262132-ENSP0000049314770 (aa)-A0A286YEZ0
ENST00000369407PHGDH-2013180--- (aa)--
ENST00000641513PHGDH-219735-ENSP00000493398165 (aa)-A0A286YFB2
ENST00000641927PHGDH-2301678--- (aa)--
ENST00000641587PHGDH-222566-ENSP0000049345363 (aa)-A0A286YFF3
ENST00000641947PHGDH-2321774-ENSP00000492994526 (aa)-A0A286YF22
ENST00000462324PHGDH-203767--- (aa)--
ENST00000641023PHGDH-2082096XM_011541226ENSP00000493175533 (aa)XP_011539528O43175
ENST00000641213PHGDH-2112053-ENSP00000493079165 (aa)-A0A286YFB2
ENST00000641371PHGDH-215725-ENSP00000493305145 (aa)-A0A286YFK5
ENST00000641314PHGDH-2141558--- (aa)--
ENST00000641074PHGDH-2091780-ENSP00000493446429 (aa)-A0A286YFL2
ENST00000641375PHGDH-2162196-ENSP00000493089165 (aa)-A0A286YFB2
ENST00000641272PHGDH-213758-ENSP00000493432239 (aa)-A0A286YFM8
ENST00000641720PHGDH-225548-ENSP0000049294872 (aa)-A0A286YF34
ENST00000641891PHGDH-2292175-ENSP00000493288165 (aa)-A0A286YFB2
ENST00000493622PHGDH-206742-ENSP0000049343389 (aa)-A0A286YFE1
ENST00000641847PHGDH-228692--- (aa)--
ENST00000469443PHGDH-204653--- (aa)--
ENST00000641939PHGDH-231540--- (aa)--
ENST00000641811PHGDH-2271031-ENSP00000493296276 (aa)-A0A286YF78
ENST00000369409PHGDH-2021882-ENSP00000358417532 (aa)-A0A2C9F2M7
ENST00000641711PHGDH-224712--- (aa)--
ENST00000496756PHGDH-207508--- (aa)--
ENST00000642021PHGDH-2332794--- (aa)--
ENST00000641115PHGDH-2101638-ENSP00000493264445 (aa)-A0A286YFA2
ENST00000482968PHGDH-2051754--- (aa)--
ENST00000641491PHGDH-218986-ENSP00000493187165 (aa)-A0A286YFB2
ENST00000641597PHGDH-2232585-ENSP00000493382533 (aa)-O43175
ENST00000641455PHGDH-217312--- (aa)--
ENST00000641573PHGDH-2211180--- (aa)--
ENST00000641570PHGDH-2201036-ENSP00000493213123 (aa)-A0A286YFC8
ENST00000641247PHGDH-212710-ENSP0000049295597 (aa)-A0A286YER3
ENST00000642041PHGDH-234943-ENSP0000049341597 (aa)-A0A286YER3
Gene Model
Click here to download ENSG00000092621's gene model file
Pathways
Pathway IDPathway NameSource
hsa00260Glycine, serine and threonine metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa01200Carbon metabolismKEGG
hsa01230Biosynthesis of amino acidsKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000092621Vascular Diseases1.4600000E-005-
ENSG00000092621Glomerular Filtration Rate3.0081764E-005-
ENSG00000092621Metabolism3E-1421886157
ENSG00000092621Macular Degeneration2E-1428250457
ENSG00000092621Amino Acids3E-2126068415
ENSG00000092621Metabolism3E-2126068415
ENSG00000092621Insulin Resistance2E-1423378610
ENSG00000092621Body Height2E-925282103
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000092621rs5233951119729854CRed blood cell count27863252[0.015-0.029] unit increase0.02186835EFO_0004305
ENSG00000092621rs4545101119652419AAlcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis287149071.206EFO_1000802|EFO_0003829|EFO_1002013
ENSG00000092621rs4780931119712503GMetabolite levels23378610EFO_0004471
ENSG00000092621rs4779921119714953AAmino acid levels26068415[0.031-0.048] unit decrease0.0397EFO_0005664|EFO_0005134
ENSG00000092621rs11632511119667132TBlood metabolite levels24816252[0.015-0.023] unit increase0.019EFO_0005664
ENSG00000092621rs6669301119716347GMultiple sclerosis240766021.08EFO_0003885
ENSG00000092621rs729886581119713339?Measles28928442[1.28-3.5] unit increase2.3883EFO_0008414
ENSG00000092621rs4779921119714953AMetabolic traits21886157[NR] unit decrease0.051EFO_0004725
ENSG00000092621rs8940791119721034?Severe gingival inflammation28459102[0.29-0.68] unit increase0.48272HP_0000225
ENSG00000092621rs121440941119722200CHeight25282103[0.017-0.033] unit increase0.025EFO_0004339
ENSG00000092621rs6378681119714487CAlanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL)28090653[1.08-2.22]1.5384616EFO_0004735|EFO_0007965|EFO_0000220
ENSG00000092621rs120727801119685572TNicotine dependence and major depression (severity of comorbidity)30287806[0.35-0.86] unit increase0.6092EFO_0009262|EFO_0007006
ENSG00000092621rs6626021119724280?Red blood cell count30595370EFO_0004305
ENSG00000092621rs6669301119716347CBreast cancer29059683[0.022-0.047] unit increase0.0347EFO_0000305
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000092621's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000092621PHGDH9463.095FBgn0032350CG62879852.923Drosophila_melanogaster
ENSG00000092621PHGDH100100.000ENSMUSG00000053398Phgdh10094.559Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004617phosphoglycerate dehydrogenase activity21873635.IBAFunction
GO:0005829cytosol-TASComponent
GO:0006520cellular amino acid metabolic process21873635.IBAProcess
GO:0006541glutamine metabolic process-IEAProcess
GO:0006544glycine metabolic process-IEAProcess
GO:0006564L-serine biosynthetic process-TASProcess
GO:0006566threonine metabolic process-IEAProcess
GO:0007420brain development8758134.TASProcess
GO:0009055electron transfer activity8758134.TASFunction
GO:0009448gamma-aminobutyric acid metabolic process-IEAProcess
GO:0010468regulation of gene expression-IEAProcess
GO:0019530taurine metabolic process-IEAProcess
GO:0021510spinal cord development-IEAProcess
GO:0021782glial cell development-IEAProcess
GO:0021915neural tube development-IEAProcess
GO:0022900electron transport chain-IEAProcess
GO:0030060L-malate dehydrogenase activity-IEAFunction
GO:0031175neuron projection development-IEAProcess
GO:0051287NAD binding-IEAFunction
GO:0070062extracellular exosome19056867.19199708.20458337.23533145.HDAComponent
GO:0070314G1 to G0 transition-IEAProcess
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