EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27246979Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells.Oncotarget2016 Jun 28Chen Sdoi: 10.18632/oncotarget.9616.
28428557The prognostic significance of Cdc6 and Cdt1 in breast cancer.Sci Rep2017 Apr 20Mahadevappa Rdoi: 10.1038/s41598-017-00998-9.
20813683[Norcantharidin inhibits DNA replication initiation protein Cdc6 in cancer cells].Nan Fang Yi Ke Da Xue Xue Bao2010 AugLi JL-
15887248Androgen receptor regulates Cdc6 in synchronized LNCaP cells progressing from G1 to S phase.J Cell Physiol2005 AugBai VU-
19101572Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma.Mutat Res2009 Mar 9Xiong XDdoi: 10.1016/j.mrfmmm.2008.11.014
26920249High expression of CDC6 is associated with accelerated cell proliferation and poor prognosis of epithelial ovarian cancer.Pathol Res Pract2016 AprDeng Ydoi: 10.1016/j.prp.2015.09.014
20606534Association between the CDC6 G1321A polymorphism and the risk of cervical cancer.Int J Gynecol Cancer2010 JulXiong XDdoi: 10.1111/IGC.0b013e3181df3cab.
25100863MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer.Mol Cancer Res2014 NovZhang Xdoi: 10.1158/1541-7786.MCR-13-0641
12006585Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer.J Biol Chem2002 Jul 12Robles LD-
19950599[Expression and clinical significance of CDC6 and hMSH2 in cervical carcinoma].Sichuan Da Xue Xue Bao Yi Xue Ban2009 SepWang WX-
24583551FOXM1 and androgen receptor co-regulate CDC6 gene transcription and DNA replication in prostate cancer cells.Biochim Biophys Acta2014Liu Ydoi: 10.1016/j.bbagrm.2014.02.016

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1740289445Nonsense_MutationNAQ9*0.38
BLCAchr1740291660Missense_MutationNAD218H0.33
BLCAchr1740301466Splice_SiteNAX485_splice0.39
BLCAchr1740293613Missense_MutationNAA273V0.23
BLCAchr1740291660Missense_MutationNAD218H0.48
BLCAchr1740293587Missense_MutationnovelM264I0.21
BLCAchr1740301975Missense_MutationNAN553D0.27
BLCAchr1740289554Missense_MutationnovelS45C0.15
BRCAchr1740294399SilentNAL327L0.13
BRCAchr1740291585Frame_Shift_DelNAA195Lfs*180.36
BRCAchr1740300902Missense_MutationNAD442H0.11
BRCAchr1740301957Missense_MutationNAD547H0.13
BRCAchr1740293968SilentNAE285E0.14
BRCAchr17402879655'UTRnovel0.81
CESCchr1740301591Missense_MutationnovelE526K0.26
COADchr17403020633'UTRnovel0.25
COADchr1740300946SilentnovelS456S0.06
COADchr1740291265Missense_MutationnovelE129G0.13
COADchr1740291132Frame_Shift_DelNAP86Lfs*170.14
COADchr17403022563'UTRnovel0.14
COADchr1740291519Missense_Mutationrs757198932R171W0.43
ESCAchr1740289489Missense_MutationnovelL23F0.11
GBMchr1740293566SilentnovelR257R0.14
HNSCchr1740294443Missense_MutationnovelL341F0.23
HNSCchr1740291621Missense_MutationnovelG205R0.16
HNSCchr1740293989SilentnovelK292K0.23
HNSCchr1740295448SilentnovelD392D0.31
KIRCchr1740293602In_Frame_InsnovelK269_H270insKM0.05
KIRCchr1740293603Frame_Shift_InsnovelH270Qfs*30.03
KIRCchr1740291228Nonsense_MutationNAQ117*0.05
KIRPchr1740291193Missense_MutationNAK105R0.12
KIRPchr1740291247Missense_MutationnovelS123L0.59
LAMLchr1740295443Silentrs774802926L391L0.1
LAMLchr1740295377Missense_MutationnovelD369H0.2
LAMLchr1740300982SilentnovelL468L0.06
LGGchr17403020563'UTRnovel0.13
LGGchr1740295355Splice_SitenovelX362_splice0.38
LUADchr1740291123Missense_MutationnovelE82Q0.11
LUADchr1740300970Missense_MutationnovelL464F0.17
LUADchr1740293584Missense_MutationnovelM263I0.49
LUADchr1740294420Missense_MutationnovelE334Q0.08
LUSCchr1740296764Missense_Mutationrs760171810E416K0.42
LUSCchr1740294414Missense_MutationnovelA332S0.28
LUSCchr1740293471Missense_MutationnovelF226L0.24
LUSCchr1740295453Missense_MutationNAC394Y0.35
LUSCchr1740296761Missense_MutationnovelS415P0.46
LUSCchr1740289482Missense_MutationnovelR21L0.31
LUSCchr1740293596SilentnovelL267L0.35
LUSCchr1740295407Frame_Shift_DelnovelK379Sfs*200.05
LUSCchr1740291289Missense_MutationNAR137T0.08
LUSCchr1740300916Missense_MutationnovelM446I0.34
LUSCchr1740291119Missense_MutationNAK80N0.29
OVchr1740291215SilentNAL112L0.41
OVchr1740300913Missense_MutationNAR445S0.8
OVchr1740289410Splice_Regionnovel0.06
PAADchr1740289441Missense_MutationnovelQ7H0.09
PRADchr1740291645Missense_MutationNAS213G0.09
READchr1740291160Missense_Mutationrs762281243R94Q0.34
READchr1740296739SilentNAS407S0.26
READchr1740291537Missense_MutationNAR177W0.21
READchr17402894185'UTRnovel0.33
READchr1740300982Missense_MutationnovelL468F0.44
SKCMchr1740293502Nonsense_MutationnovelL236*0.41
SKCMchr1740291530SilentnovelA174A0.45
SKCMchr1740291559Missense_MutationNAN184T0.14
SKCMchr1740301596SilentnovelT527T0.08
SKCMchr1740294408Missense_MutationnovelL330F0.32
STADchr1740301980Missense_Mutationrs542837328I554M0.33
STADchr1740291477Missense_MutationNAY157N0.05
STADchr1740295435Missense_MutationnovelR388H0.15
STADchr1740293495Missense_MutationNAM234L0.05
STADchr1740294383Missense_MutationNAD321E0.09
STADchr1740301027SilentnovelG483G0.05
STADchr17403021433'UTRrs1386511430.31
STADchr1740291581Nonsense_MutationNAC191*0.1
STADchr1740295424In_Frame_DelnovelG385del0.06
STADchr1740294447Missense_MutationNAF343L0.09
UCECchr1740301013Nonsense_MutationNAE479*0.31
UCECchr1740291080Frame_Shift_InsnovelH69Pfs*240.28
UCECchr1740291306Nonsense_MutationnovelE143*0.43
UCECchr1740291529Missense_MutationnovelA174V0.11
UCECchr1740293607Missense_MutationnovelM271T0.29
UCECchr17403020833'UTRnovel0.42
UCECchr17402894195'UTRnovel0.5
UCECchr1740301593Missense_MutationnovelE526D0.57
UCECchr1740301490Missense_MutationNAV492A0.38
UCECchr1740293612Missense_Mutationrs767841312A273T0.24
UCECchr1740291095SilentnovelP72P0.21
UCECchr1740289438Silentrs143031736S6S0.48
UCECchr17403021193'UTRnovel0.53
UCECchr1740301028Missense_MutationnovelK484E0.38
UCECchr1740291155Missense_MutationnovelK92N0.55
UCECchr1740295405Missense_Mutationrs4135016R378H0.32
UCECchr1740301521SilentnovelD502D0.15
UCECchr1740294010SilentnovelT299T0.07
UCECchr1740295357Missense_MutationNAV362A0.26
UCECchr1740293555Missense_MutationnovelE254Q0.06
UCECchr1740300935Missense_MutationnovelA453S0.05
UCECchr1740301543Missense_MutationnovelS510A0.45
UCECchr1740301563Missense_MutationNAR516S0.33
UCECchr1740294048Missense_MutationnovelV312A0.38
UCECchr1740293581SilentnovelD262D0.34
UCSchr1740301969Missense_MutationnovelI551L0.32

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.26670.0017784
DLBCDEL00.18166
THCADEL0.0020.221
UCSDEL0.33930.19877
UVMDEL0.03750.22482

Survival Analysis
CancerP-value Q-value
THYM0.01

Kaplan-Meier Survival Analysis

KIRC0.0003

Kaplan-Meier Survival Analysis

SARC0.025

Kaplan-Meier Survival Analysis

MESO0.00011

Kaplan-Meier Survival Analysis

SKCM0.0014

Kaplan-Meier Survival Analysis

LUSC0.05

Kaplan-Meier Survival Analysis

KIRP0.0001

Kaplan-Meier Survival Analysis

COAD0.018

Kaplan-Meier Survival Analysis

PAAD0.00043

Kaplan-Meier Survival Analysis

READ0.007

Kaplan-Meier Survival Analysis

KICH0.0082

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

THCA0.048

Kaplan-Meier Survival Analysis

LUAD0.00047

Kaplan-Meier Survival Analysis

UVM0.0034

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000094804 (Gene tree)
Gene ID
990
Gene Symbol
CDC6
Alias
CDC18L
Full Name
cell division cycle 6
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
17,025 bases
Position
chr17:40,287,633-40,304,657
Accession
1744
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
31064870The RNA-Binding Protein HuR Confers Oxaliplatin Resistance of Colorectal Cancer By Upregulating CDC6.Mol Cancer Ther2019 JulCai Jdoi: 10.1158/1535-7163.MCT-18-0945
21212384ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors.J Natl Cancer Inst2011 Feb 16Dasgupta Pdoi: 10.1093/jnci/djq541
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000649662CDC6-2081948-ENSP00000497345560 (aa)-A0A024R1S2
ENST00000647931CDC6-2062820XM_011525541ENSP00000497975560 (aa)XP_011523843A0A024R1S2
ENST00000473555CDC6-202584-ENSP00000464047118 (aa)-J3QR52
ENST00000577249CDC6-203541-ENSP00000463004100 (aa)-J3KTI7
ENST00000580824CDC6-204696-ENSP00000463635182 (aa)-J3QLN7
ENST00000209728CDC6-2014810-ENSP00000209728560 (aa)-Q99741
ENST00000582402CDC6-205353--- (aa)--
ENST00000648633CDC6-207739--- (aa)--
Gene Model
Click here to download ENSG00000094804's gene model file
Pathways
Pathway IDPathway NameSource
hsa04110Cell cycleKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000094804's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000094804CDC610079.929ENSMUSG00000017499Cdc610079.929Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000076DNA replication checkpoint9566895.TASProcess
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity9566895.TASProcess
GO:0000082G1/S transition of mitotic cell cycle-TASProcess
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle-TASProcess
GO:0000166nucleotide binding8990175.TASFunction
GO:0000278mitotic cell cycle21873635.IBAProcess
GO:0000278mitotic cell cycle22581055.IMPProcess
GO:0000922spindle pole21041660.IDAComponent
GO:0003688DNA replication origin binding21873635.IBAFunction
GO:0005515protein binding14672932.15232106.19150984.21041660.23397142.25241761.25990725.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus21041660.21383955.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus21383955.IDAComponent
GO:0005737cytoplasm9566895.TASComponent
GO:0005829cytosol-TASComponent
GO:0006260DNA replication-TASProcess
GO:0006270DNA replication initiation-IEAProcess
GO:0007089traversing start control point of mitotic cell cycle9566895.TASProcess
GO:0008156negative regulation of DNA replication9566895.TASProcess
GO:0008285negative regulation of cell proliferation9566895.TASProcess
GO:0019900kinase binding21041660.IPIFunction
GO:0030071regulation of mitotic metaphase/anaphase transition21041660.IMPProcess
GO:0032467positive regulation of cytokinesis21041660.IMPProcess
GO:0033314mitotic DNA replication checkpoint21873635.IBAProcess
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IEAProcess
GO:0048146positive regulation of fibroblast proliferation-IEAProcess
GO:0051233spindle midzone21041660.IDAComponent
GO:0051301cell division-IEAProcess
GO:0051984positive regulation of chromosome segregation21041660.IDAProcess
GO:1904117cellular response to vasopressin-IEAProcess
GO:1904385cellular response to angiotensin-IEAProcess
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