EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27246979	Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells.	Oncotarget	2016 Jun 28	Chen S	doi: 10.18632/oncotarget.9616.
28428557	The prognostic significance of Cdc6 and Cdt1 in breast cancer.	Sci Rep	2017 Apr 20	Mahadevappa R	doi: 10.1038/s41598-017-00998-9.
20813683	[Norcantharidin inhibits DNA replication initiation protein Cdc6 in cancer cells].	Nan Fang Yi Ke Da Xue Xue Bao	2010 Aug	Li JL	-
15887248	Androgen receptor regulates Cdc6 in synchronized LNCaP cells progressing from G1 to S phase.	J Cell Physiol	2005 Aug	Bai VU	-
19101572	Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma.	Mutat Res	2009 Mar 9	Xiong XD	doi: 10.1016/j.mrfmmm.2008.11.014
26920249	High expression of CDC6 is associated with accelerated cell proliferation and poor prognosis of epithelial ovarian cancer.	Pathol Res Pract	2016 Apr	Deng Y	doi: 10.1016/j.prp.2015.09.014
20606534	Association between the CDC6 G1321A polymorphism and the risk of cervical cancer.	Int J Gynecol Cancer	2010 Jul	Xiong XD	doi: 10.1111/IGC.0b013e3181df3cab.
25100863	MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer.	Mol Cancer Res	2014 Nov	Zhang X	doi: 10.1158/1541-7786.MCR-13-0641
12006585	Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer.	J Biol Chem	2002 Jul 12	Robles LD	-
19950599	[Expression and clinical significance of CDC6 and hMSH2 in cervical carcinoma].	Sichuan Da Xue Xue Bao Yi Xue Ban	2009 Sep	Wang WX	-
24583551	FOXM1 and androgen receptor co-regulate CDC6 gene transcription and DNA replication in prostate cancer cells.	Biochim Biophys Acta	2014	Liu Y	doi: 10.1016/j.bbagrm.2014.02.016

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	40289445	Nonsense_Mutation	NA	Q9*	0.38
BLCA	chr17	40291660	Missense_Mutation	NA	D218H	0.33
BLCA	chr17	40301466	Splice_Site	NA	X485_splice	0.39
BLCA	chr17	40293613	Missense_Mutation	NA	A273V	0.23
BLCA	chr17	40291660	Missense_Mutation	NA	D218H	0.48
BLCA	chr17	40293587	Missense_Mutation	novel	M264I	0.21
BLCA	chr17	40301975	Missense_Mutation	NA	N553D	0.27
BLCA	chr17	40289554	Missense_Mutation	novel	S45C	0.15
BRCA	chr17	40294399	Silent	NA	L327L	0.13
BRCA	chr17	40291585	Frame_Shift_Del	NA	*A195Lfs18**	0.36
BRCA	chr17	40300902	Missense_Mutation	NA	D442H	0.11
BRCA	chr17	40301957	Missense_Mutation	NA	D547H	0.13
BRCA	chr17	40293968	Silent	NA	E285E	0.14
BRCA	chr17	40287965	5'UTR	novel		0.81
CESC	chr17	40301591	Missense_Mutation	novel	E526K	0.26
COAD	chr17	40302063	3'UTR	novel		0.25
COAD	chr17	40300946	Silent	novel	S456S	0.06
COAD	chr17	40291265	Missense_Mutation	novel	E129G	0.13
COAD	chr17	40291132	Frame_Shift_Del	NA	*P86Lfs17**	0.14
COAD	chr17	40302256	3'UTR	novel		0.14
COAD	chr17	40291519	Missense_Mutation	rs757198932	R171W	0.43
ESCA	chr17	40289489	Missense_Mutation	novel	L23F	0.11
GBM	chr17	40293566	Silent	novel	R257R	0.14
HNSC	chr17	40294443	Missense_Mutation	novel	L341F	0.23
HNSC	chr17	40291621	Missense_Mutation	novel	G205R	0.16
HNSC	chr17	40293989	Silent	novel	K292K	0.23
HNSC	chr17	40295448	Silent	novel	D392D	0.31
KIRC	chr17	40293602	In_Frame_Ins	novel	K269_H270insKM	0.05
KIRC	chr17	40293603	Frame_Shift_Ins	novel	*H270Qfs3**	0.03
KIRC	chr17	40291228	Nonsense_Mutation	NA	Q117*	0.05
KIRP	chr17	40291193	Missense_Mutation	NA	K105R	0.12
KIRP	chr17	40291247	Missense_Mutation	novel	S123L	0.59
LAML	chr17	40295443	Silent	rs774802926	L391L	0.1
LAML	chr17	40295377	Missense_Mutation	novel	D369H	0.2
LAML	chr17	40300982	Silent	novel	L468L	0.06
LGG	chr17	40302056	3'UTR	novel		0.13
LGG	chr17	40295355	Splice_Site	novel	X362_splice	0.38
LUAD	chr17	40291123	Missense_Mutation	novel	E82Q	0.11
LUAD	chr17	40300970	Missense_Mutation	novel	L464F	0.17
LUAD	chr17	40293584	Missense_Mutation	novel	M263I	0.49
LUAD	chr17	40294420	Missense_Mutation	novel	E334Q	0.08
LUSC	chr17	40296764	Missense_Mutation	rs760171810	E416K	0.42
LUSC	chr17	40294414	Missense_Mutation	novel	A332S	0.28
LUSC	chr17	40293471	Missense_Mutation	novel	F226L	0.24
LUSC	chr17	40295453	Missense_Mutation	NA	C394Y	0.35
LUSC	chr17	40296761	Missense_Mutation	novel	S415P	0.46
LUSC	chr17	40289482	Missense_Mutation	novel	R21L	0.31
LUSC	chr17	40293596	Silent	novel	L267L	0.35
LUSC	chr17	40295407	Frame_Shift_Del	novel	*K379Sfs20**	0.05
LUSC	chr17	40291289	Missense_Mutation	NA	R137T	0.08
LUSC	chr17	40300916	Missense_Mutation	novel	M446I	0.34
LUSC	chr17	40291119	Missense_Mutation	NA	K80N	0.29
OV	chr17	40291215	Silent	NA	L112L	0.41
OV	chr17	40300913	Missense_Mutation	NA	R445S	0.8
OV	chr17	40289410	Splice_Region	novel		0.06
PAAD	chr17	40289441	Missense_Mutation	novel	Q7H	0.09
PRAD	chr17	40291645	Missense_Mutation	NA	S213G	0.09
READ	chr17	40291160	Missense_Mutation	rs762281243	R94Q	0.34
READ	chr17	40296739	Silent	NA	S407S	0.26
READ	chr17	40291537	Missense_Mutation	NA	R177W	0.21
READ	chr17	40289418	5'UTR	novel		0.33
READ	chr17	40300982	Missense_Mutation	novel	L468F	0.44
SKCM	chr17	40293502	Nonsense_Mutation	novel	L236*	0.41
SKCM	chr17	40291530	Silent	novel	A174A	0.45
SKCM	chr17	40291559	Missense_Mutation	NA	N184T	0.14
SKCM	chr17	40301596	Silent	novel	T527T	0.08
SKCM	chr17	40294408	Missense_Mutation	novel	L330F	0.32
STAD	chr17	40301980	Missense_Mutation	rs542837328	I554M	0.33
STAD	chr17	40291477	Missense_Mutation	NA	Y157N	0.05
STAD	chr17	40295435	Missense_Mutation	novel	R388H	0.15
STAD	chr17	40293495	Missense_Mutation	NA	M234L	0.05
STAD	chr17	40294383	Missense_Mutation	NA	D321E	0.09
STAD	chr17	40301027	Silent	novel	G483G	0.05
STAD	chr17	40302143	3'UTR	rs138651143		0.31
STAD	chr17	40291581	Nonsense_Mutation	NA	C191*	0.1
STAD	chr17	40295424	In_Frame_Del	novel	G385del	0.06
STAD	chr17	40294447	Missense_Mutation	NA	F343L	0.09
UCEC	chr17	40301013	Nonsense_Mutation	NA	E479*	0.31
UCEC	chr17	40291080	Frame_Shift_Ins	novel	*H69Pfs24**	0.28
UCEC	chr17	40291306	Nonsense_Mutation	novel	E143*	0.43
UCEC	chr17	40291529	Missense_Mutation	novel	A174V	0.11
UCEC	chr17	40293607	Missense_Mutation	novel	M271T	0.29
UCEC	chr17	40302083	3'UTR	novel		0.42
UCEC	chr17	40289419	5'UTR	novel		0.5
UCEC	chr17	40301593	Missense_Mutation	novel	E526D	0.57
UCEC	chr17	40301490	Missense_Mutation	NA	V492A	0.38
UCEC	chr17	40293612	Missense_Mutation	rs767841312	A273T	0.24
UCEC	chr17	40291095	Silent	novel	P72P	0.21
UCEC	chr17	40289438	Silent	rs143031736	S6S	0.48
UCEC	chr17	40302119	3'UTR	novel		0.53
UCEC	chr17	40301028	Missense_Mutation	novel	K484E	0.38
UCEC	chr17	40291155	Missense_Mutation	novel	K92N	0.55
UCEC	chr17	40295405	Missense_Mutation	rs4135016	R378H	0.32
UCEC	chr17	40301521	Silent	novel	D502D	0.15
UCEC	chr17	40294010	Silent	novel	T299T	0.07
UCEC	chr17	40295357	Missense_Mutation	NA	V362A	0.26
UCEC	chr17	40293555	Missense_Mutation	novel	E254Q	0.06
UCEC	chr17	40300935	Missense_Mutation	novel	A453S	0.05
UCEC	chr17	40301543	Missense_Mutation	novel	S510A	0.45
UCEC	chr17	40301563	Missense_Mutation	NA	R516S	0.33
UCEC	chr17	40294048	Missense_Mutation	novel	V312A	0.38
UCEC	chr17	40293581	Silent	novel	D262D	0.34
UCS	chr17	40301969	Missense_Mutation	novel	I551L	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2667	0.0017784
DLBC	DEL	0	0.18166
THCA	DEL	0.002	0.221
UCS	DEL	0.3393	0.19877
UVM	DEL	0.0375	0.22482

Survival Analysis

Cancer	P-value	Q-value
THYM	0.01	Kaplan-Meier Survival Analysis
KIRC	0.0003	Kaplan-Meier Survival Analysis
SARC	0.025	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.0014	Kaplan-Meier Survival Analysis
LUSC	0.05	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
COAD	0.018	Kaplan-Meier Survival Analysis
PAAD	0.00043	Kaplan-Meier Survival Analysis
READ	0.007	Kaplan-Meier Survival Analysis
KICH	0.0082	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
THCA	0.048	Kaplan-Meier Survival Analysis
LUAD	0.00047	Kaplan-Meier Survival Analysis
UVM	0.0034	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000094804 (Gene tree)
Gene ID: 990
Gene Symbol: CDC6
Alias: CDC18L
Full Name: cell division cycle 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 17,025 bases
Position: chr17:40,287,633-40,304,657
Accession: 1744
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31064870	The RNA-Binding Protein HuR Confers Oxaliplatin Resistance of Colorectal Cancer By Upregulating CDC6.	Mol Cancer Ther	2019 Jul	Cai J	doi: 10.1158/1535-7163.MCT-18-0945
21212384	ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors.	J Natl Cancer Inst	2011 Feb 16	Dasgupta P	doi: 10.1093/jnci/djq541

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000649662	CDC6-208	1948	-	ENSP00000497345	560 (aa)	-	A0A024R1S2
ENST00000647931	CDC6-206	2820	XM_011525541	ENSP00000497975	560 (aa)	XP_011523843	A0A024R1S2
ENST00000473555	CDC6-202	584	-	ENSP00000464047	118 (aa)	-	J3QR52
ENST00000577249	CDC6-203	541	-	ENSP00000463004	100 (aa)	-	J3KTI7
ENST00000580824	CDC6-204	696	-	ENSP00000463635	182 (aa)	-	J3QLN7
ENST00000209728	CDC6-201	4810	-	ENSP00000209728	560 (aa)	-	Q99741
ENST00000582402	CDC6-205	353	-	-	- (aa)	-	-
ENST00000648633	CDC6-207	739	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000094804's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000094804's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000094804	CDC6	100	79.929	ENSMUSG00000017499	Cdc6	100	79.929	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000076	DNA replication checkpoint	9566895.	TAS	Process
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	9566895.	TAS	Process
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	Process
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	-	TAS	Process
GO:0000166	nucleotide binding	8990175.	TAS	Function
GO:0000278	mitotic cell cycle	21873635.	IBA	Process
GO:0000278	mitotic cell cycle	22581055.	IMP	Process
GO:0000922	spindle pole	21041660.	IDA	Component
GO:0003688	DNA replication origin binding	21873635.	IBA	Function
GO:0005515	protein binding	14672932.15232106.19150984.21041660.23397142.25241761.25990725.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21041660.21383955.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	21383955.	IDA	Component
GO:0005737	cytoplasm	9566895.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006260	DNA replication	-	TAS	Process
GO:0006270	DNA replication initiation	-	IEA	Process
GO:0007089	traversing start control point of mitotic cell cycle	9566895.	TAS	Process
GO:0008156	negative regulation of DNA replication	9566895.	TAS	Process
GO:0008285	negative regulation of cell proliferation	9566895.	TAS	Process
GO:0019900	kinase binding	21041660.	IPI	Function
GO:0030071	regulation of mitotic metaphase/anaphase transition	21041660.	IMP	Process
GO:0032467	positive regulation of cytokinesis	21041660.	IMP	Process
GO:0033314	mitotic DNA replication checkpoint	21873635.	IBA	Process
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	-	IEA	Process
GO:0048146	positive regulation of fibroblast proliferation	-	IEA	Process
GO:0051233	spindle midzone	21041660.	IDA	Component
GO:0051301	cell division	-	IEA	Process
GO:0051984	positive regulation of chromosome segregation	21041660.	IDA	Process
GO:1904117	cellular response to vasopressin	-	IEA	Process
GO:1904385	cellular response to angiotensin	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.