EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27566589	ERMP1, a novel potential oncogene involved in UPR and oxidative stress defense, is highly expressed in human cancer.	Oncotarget	2016 Sep 27	Grandi A	doi: 10.18632/oncotarget.11550.
29523216	miR-148b Functions as a Tumor Suppressor by Targeting Endoplasmic Reticulum Metallo Protease 1 in Human Endometrial Cancer Cells.	Oncol Res	2018 Dec 27	Qu J	doi: 10.3727/096504018X15202988139874

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr9	5823987	Silent	novel	F261F	0.15
BLCA	chr9	5810173	Silent	novel	F462F	0.46
BLCA	chr9	5830743	Silent	rs768978196	S208S	0.46
BLCA	chr9	5812933	Missense_Mutation	rs151153615	S326L	0.39
BRCA	chr9	5787132	3'UTR	novel		0.07
BRCA	chr9	5812823	Intron	novel		0.26
BRCA	chr9	5805055	Missense_Mutation	NA	G629V	0.29
BRCA	chr9	5805716	Missense_Mutation	NA	V540F	0.16
BRCA	chr9	5798929	Frame_Shift_Del	novel	*K704Ifs7**	0.06
BRCA	chr9	5798897	Missense_Mutation	novel	P727T	0.11
BRCA	chr9	5830922	Missense_Mutation	NA	V149L	0.36
BRCA	chr9	5787227	Missense_Mutation	NA	Q878E	0.13
BRCA	chr9	5798979	In_Frame_Ins	novel	E699delinsDIK	0.13
BRCA	chr9	5798981	Nonsense_Mutation	novel	E699*	0.07
BRCA	chr9	5812870	Intron	novel		0.5
BRCA	chr9	5805749	Frame_Shift_Ins	NA	D529*	0.16
CESC	chr9	5787197	Frame_Shift_Ins	novel	D888*	0.25
CESC	chr9	5812919	Missense_Mutation	novel	R331C	0.08
CESC	chr9	5787458	Missense_Mutation	NA	S841C	0.32
COAD	chr9	5825132	Missense_Mutation	NA	V243A	0.38
COAD	chr9	5830851	Missense_Mutation	novel	F172L	0.13
COAD	chr9	5787076	3'UTR	rs751754928		0.19
COAD	chr9	5787593	Missense_Mutation	NA	G796E	0.16
COAD	chr9	5787594	Splice_Site	NA	X796_splice	0.16
COAD	chr9	5810077	Silent	NA	L494L	0.43
COAD	chr9	5810164	Silent	novel	L465L	0.19
COAD	chr9	5797866	Silent	novel	S779S	0.16
COAD	chr9	5805061	Frame_Shift_Del	NA	*L627Wfs6**	0.25
COAD	chr9	5811134	Missense_Mutation	NA	K435T	0.2
COAD	chr9	5810057	Missense_Mutation	NA	A501D	0.22
COAD	chr9	5801292	Frame_Shift_Del	rs766083890	*T651Pfs3**	0.36
ESCA	chr9	5784880	3'UTR	novel		0.67
GBM	chr9	5801254	Silent	rs765336851	F663F	0.18
GBM	chr9	5812784	Intron	novel		0.17
GBM	chr9	5787462	Missense_Mutation	novel	A840P	0.18
HNSC	chr9	5787438	Missense_Mutation	novel	E848Q	0.39
HNSC	chr9	5823980	Nonsense_Mutation	novel	Q264*	0.12
HNSC	chr9	5797843	Missense_Mutation	novel	S787Y	0.22
HNSC	chr9	5810094	Missense_Mutation	novel	Y489H	0.22
HNSC	chr9	5805208	Missense_Mutation	novel	G578E	0.16
KIRC	chr9	5811273	Missense_Mutation	NA	A389T	0.48
KIRP	chr9	5801231	Missense_Mutation	NA	F671Y	0.41
LAML	chr9	5787535	Nonsense_Mutation	novel	W815*	0.05
LIHC	chr9	5787026	3'UTR	novel		0.35
LUAD	chr9	5812822	Intron	novel		0.29
LUAD	chr9	5787065	3'UTR	novel		0.2
LUAD	chr9	5805687	Silent	rs775253188	S549S	0.08
LUAD	chr9	5805697	Missense_Mutation	novel	G546V	0.28
LUSC	chr9	5833008	Missense_Mutation	NA	S7L	0.53
LUSC	chr9	5812907	Missense_Mutation	novel	D335N	0.14
LUSC	chr9	5811263	Missense_Mutation	novel	S392C	0.27
OV	chr9	5830845	Silent	novel	G174G	0.1
OV	chr9	5801200	Silent	NA	P681P	0.09
PRAD	chr9	5798848	Missense_Mutation	NA	L743R	0.07
READ	chr9	5805753	Missense_Mutation	NA	F527L	0.28
READ	chr9	5810029	Silent	rs575924523	A510A	0.36
READ	chr9	5797837	Missense_Mutation	NA	K789T	0.2
READ	chr9	5787008	3'UTR	novel		0.34
READ	chr9	5797907	Nonsense_Mutation	novel	E766*	0.05
READ	chr9	5812130	Missense_Mutation	novel	R370I	0.39
READ	chr9	5811194	Missense_Mutation	rs749246662	R415H	0.49
SKCM	chr9	5812837	Intron	novel		0.25
SKCM	chr9	5830894	Missense_Mutation	rs751332099	S158L	0.39
SKCM	chr9	5787086	3'UTR	novel		0.25
SKCM	chr9	5832913	Silent	NA	L39L	0.83
SKCM	chr9	5805111	Silent	rs754533913	L610L	0.24
SKCM	chr9	5832940	Missense_Mutation	novel	E30K	0.48
SKCM	chr9	5805118	Missense_Mutation	NA	P608L	0.59
STAD	chr9	5805111	Silent	rs754533913	L610L	0.14
STAD	chr9	5805191	Frame_Shift_Del	novel	*Y584Tfs49**	0.24
STAD	chr9	5801292	Frame_Shift_Del	rs766083890	*T651Pfs3**	0.28
STAD	chr9	5801291	Frame_Shift_Ins	rs753821453	*T651Nfs25**	0.27
STAD	chr9	5797844	Missense_Mutation	NA	S787A	0.26
STAD	chr9	5810125	Missense_Mutation	NA	I478M	0.44
STAD	chr9	5787567	Nonsense_Mutation	rs774581636	R805*	0.15
STAD	chr9	5801227	Frame_Shift_Del	novel	*P673Hfs19**	0.21
STAD	chr9	5801292	Frame_Shift_Del	rs766083890	*T651Pfs3**	0.36
STAD	chr9	5811260	Missense_Mutation	NA	K393T	0.21
STAD	chr9	5801292	Frame_Shift_Del	novel	*K650Nfs25**	0.27
THCA	chr9	5812998	Silent	NA	S304S	0.39
UCEC	chr9	5801303	Missense_Mutation	NA	S647N	0.05
UCEC	chr9	5811204	Missense_Mutation	novel	Y412H	0.28
UCEC	chr9	5825171	Missense_Mutation	rs778526397	R230H	0.19
UCEC	chr9	5805702	Nonsense_Mutation	novel	Y544*	0.09
UCEC	chr9	5831028	Splice_Region	rs761553950	R113R	0.12
UCEC	chr9	5787495	Missense_Mutation	novel	D829N	0.06
UCEC	chr9	5798875	Missense_Mutation	rs777428417	R734Q	0.49
UCEC	chr9	5805715	Missense_Mutation	NA	V540A	0.11
UCEC	chr9	5812187	Missense_Mutation	novel	Y351C	0.03
UCEC	chr9	5798972	Nonsense_Mutation	novel	*N701_A702insTNTTELVYRM**	0.14
UCEC	chr9	5801252	Missense_Mutation	NA	L664R	0.41
UCEC	chr9	5798875	Missense_Mutation	rs777428417	R734Q	0.47
UCEC	chr9	5798972	Frame_Shift_Ins	novel	*A702Kfs24**	0.1
UCEC	chr9	5811114	Missense_Mutation	NA	K442E	0.37
UCEC	chr9	5797883	Missense_Mutation	novel	H774Y	0.38
UCEC	chr9	5798820	Silent	novel	V752V	0.31
UCEC	chr9	5830753	Missense_Mutation	novel	H205P	0.58
UCEC	chr9	5787262	Missense_Mutation	novel	A866V	0.2
UCEC	chr9	5812819	Intron	novel		0.48
UCEC	chr9	5801292	Frame_Shift_Del	rs766083890	*T651Pfs3**	0.25
UCEC	chr9	5805688	Missense_Mutation	rs150106740	S549L	0.54
UCEC	chr9	5810215	Missense_Mutation	novel	K448N	0.56
UCEC	chr9	5811110	Splice_Site	novel	X443_splice	0.48
UCEC	chr9	5801266	Silent	novel	C659C	0.08
UCEC	chr9	5797933	Splice_Site	NA	X757_splice	0.32
UCEC	chr9	5823955	Missense_Mutation	rs141023353	R272H	0.4
UCEC	chr9	5784829	3'UTR	novel		0.28
UCEC	chr9	5797842	Silent	rs373212832	S787S	0.33
UCEC	chr9	5801291	Frame_Shift_Ins	rs753821453	*T651Nfs25**	0.47
UCEC	chr9	5784788	3'UTR	novel		0.21
UCEC	chr9	5805110	Missense_Mutation	novel	G611R	0.26
UCEC	chr9	5787008	3'UTR	novel		0.63
UCEC	chr9	5812861	Intron	novel		0.15
UCEC	chr9	5798939	Missense_Mutation	novel	G713R	0.39
UCEC	chr9	5830856	Missense_Mutation	novel	D171Y	0.26
UCEC	chr9	5784778	3'UTR	rs551444794		0.45
UCEC	chr9	5811254	Missense_Mutation	rs774713963	R395Q	0.36
UCEC	chr9	5812143	Missense_Mutation	novel	D366Y	0.36
UCEC	chr9	5830899	Silent	novel	K156K	0.64
UCEC	chr9	5810072	Missense_Mutation	NA	G496E	0.41
UCEC	chr9	5787456	Missense_Mutation	novel	A842T	0.28
UCEC	chr9	5798921	Missense_Mutation	novel	I719F	0.37
UCEC	chr9	5784629	3'UTR	novel		0.42
UCEC	chr9	5787008	3'UTR	novel		0.29
UCEC	chr9	5810098	Silent	novel	H487H	0.38
UCEC	chr9	5810024	Missense_Mutation	rs374389047	R512I	0.5
UCEC	chr9	5811277	Missense_Mutation	NA	M387I	0.31
UCEC	chr9	5805644	Missense_Mutation	NA	K564Q	0.21
UCEC	chr9	5812195	Missense_Mutation	NA	E348D	0.3
UCEC	chr9	5801200	Silent	rs775344090	P681P	0.23
UCEC	chr9	5830971	Silent	novel	N132N	0.23
UCEC	chr9	5805206	Missense_Mutation	novel	K579E	0.25
UCEC	chr9	5830861	Missense_Mutation	novel	S169N	0.15
UCEC	chr9	5805719	Missense_Mutation	novel	L539I	0.48
UCS	chr9	5805106	Missense_Mutation	NA	R612I	0.16
UCS	chr9	5810024	Missense_Mutation	rs374389047	R512I	0.14
UCS	chr9	5811254	Missense_Mutation	rs774713963	R395Q	0.23
UCS	chr9	5787228	Silent	novel	P877P	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.1569	0.073854
LAML	DEL	0.0052	0.24147
OV	DEL	0.4283	0.00059831
TGCT	DEL	0.38	7.3329e-05
THCA	DEL	0.0301	0.24038
THYM	DEL	0.0325	0.022012

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00015	Kaplan-Meier Survival Analysis
STAD	0.046	Kaplan-Meier Survival Analysis
MESO	0.012	Kaplan-Meier Survival Analysis
BRCA	0.03	Kaplan-Meier Survival Analysis
READ	0.012	Kaplan-Meier Survival Analysis
LIHC	0.0051	Kaplan-Meier Survival Analysis
LGG	0.035	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000099219 (Gene tree)
Gene ID: 79956
Gene Symbol: ERMP1
Alias: FLJ23309|FXNA|KIAA1815
Full Name: endoplasmic reticulum metallopeptidase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 69,057 bases
Position: chr9:5,764,061-5,833,117
Accession: 23703
RBP type: non-canonical RBP
Summary: (Endoplasmic Reticulum Metallopeptidase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and metallopeptidase activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000214893	ERMP1-201	4974	-	-	- (aa)	-	-
ENST00000339450	ERMP1-202	5376	XM_005251587	ENSP00000340427	904 (aa)	XP_005251644	Q7Z2K6
ENST00000487088	ERMP1-205	2799	-	ENSP00000432986	351 (aa)	-	A0A0C4DGF0
ENST00000489219	ERMP1-206	3293	-	ENSP00000417474	841 (aa)	-	E7ER77
ENST00000475005	ERMP1-204	1219	-	-	- (aa)	-	-
ENST00000462592	ERMP1-203	3554	-	ENSP00000417160	904 (aa)	-	Q7Z2K6

Gene Model

Click here to download ENSG00000099219's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000099219	Parkinson Disease	1.963E-5	16252231
ENSG00000099219	Parkinson Disease	4.468E-5	16252231

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000099219	rs10975277	9	5774661	?	Respiratory diseases	30595370			EFO_0000684
ENSG00000099219	rs2093657	9	5783498	C	Blond vs. brown/black hair color	30531825	NR	1.055	EFO_0003924

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000099219's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000099219	ERMP1	100	88.889	ENSMUSG00000046324	Ermp1	100	85.177	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0006508	proteolysis	-	IEA	Process
GO:0008237	metallopeptidase activity	-	IEA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.