EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25373480	Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer.	Mol Cancer Res	2015 Mar	Salz T	doi: 10.1158/1541-7786.MCR-14-0389
24247718	hSETD1A regulates Wnt target genes and controls tumor growth of colorectal cancer cells.	Cancer Res	2014 Feb 1	Salz T	doi: 10.1158/0008-5472.CAN-13-1400
26865005	SETD1A induced miRNA network suppresses the p53 gene expression module.	Cell Cycle	2016	Yae T	doi: 10.1080/15384101.2015.1130572
30191958	Aberrant expression of SETD1A promotes survival and migration of estrogen receptor α-positive breast cancer cells.	Int J Cancer	2018 Dec 1	Jin ML	doi: 10.1002/ijc.31853

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr16	30965624	Silent	rs146323096	D581D	0.51
BLCA	chr16	30966173	Silent	rs758850246	V764V	0.29
BLCA	chr16	30983894	Silent	NA	K1665K	0.44
BLCA	chr16	30964764	Missense_Mutation	rs138671480	S341F	0.42
BLCA	chr16	30981107	Missense_Mutation	NA	W1580L	0.14
BLCA	chr16	30965946	Missense_Mutation	novel	R689G	0.06
BLCA	chr16	30961446	Silent	novel	F142F	0.14
BLCA	chr16	30964788	Missense_Mutation	rs746239302	S349L	0.05
BLCA	chr16	30965985	Missense_Mutation	rs150802841	A702T	0.12
BLCA	chr16	30979571	Missense_Mutation	NA	T1262N	0.19
BLCA	chr16	30971430	Silent	novel	S1023S	0.24
BLCA	chr16	30966059	Silent	rs750394524	Y726Y	0.55
BLCA	chr16	30966372	Missense_Mutation	novel	E831K	0.21
BLCA	chr16	30963515	Silent	novel	L200L	0.12
BLCA	chr16	30971685	Silent	rs762162678	L1108L	0.41
BRCA	chr16	30964243	Silent	NA	F263F	0.47
BRCA	chr16	30964988	Missense_Mutation	NA	E416K	0.22
BRCA	chr16	30965831	Silent	rs762179315	P650P	0.23
BRCA	chr16	30980094	Silent	rs759060692	D1436D	0.13
BRCA	chr16	30981139	Missense_Mutation	novel	D1591H	0.44
BRCA	chr16	30980085	Silent	novel	S1433S	0.31
BRCA	chr16	30958800	Silent	NA	I23I	0.22
BRCA	chr16	30964996	Silent	NA	S418S	0.37
CESC	chr16	30969322	Nonsense_Mutation	novel	E930*	0.2
CESC	chr16	30971416	Silent	novel	L1019L	0.35
CESC	chr16	30964641	Missense_Mutation	rs772128818	R300Q	0.51
CESC	chr16	30979258	Missense_Mutation	novel	L1158M	0.34
CESC	chr16	30984341	3'UTR	novel		0.57
CESC	chr16	30980582	Silent	NA	I1502I	0.25
CESC	chr16	30964723	Silent	novel	I327I	0.28
CESC	chr16	30961462	Missense_Mutation	novel	A148T	0.44	RRM_1
COAD	chr16	30971699	Missense_Mutation	rs199662660	A1113V	0.14
COAD	chr16	30965867	Silent	NA	S662S	0.12
COAD	chr16	30971711	Missense_Mutation	NA	R1117M	0.2
COAD	chr16	30979474	Missense_Mutation	rs775225592	R1230W	0.35
COAD	chr16	30964176	Frame_Shift_Del	novel	*C243Afs254**	0.08
COAD	chr16	30965996	Frame_Shift_Del	NA	*G708Vfs95**	0.19
COAD	chr16	30963491	Frame_Shift_Del	NA	*V193Afs9**	0.44
COAD	chr16	30966316	Missense_Mutation	NA	R812L	0.31
COAD	chr16	30979162	Frame_Shift_Del	novel	*S1128Vfs134**	0.13
COAD	chr16	30981127	Missense_Mutation	novel	P1587S	0.09
COAD	chr16	30971400	Silent	rs745753391	S1013S	0.38
COAD	chr16	30965930	Missense_Mutation	NA	Q683H	0.51
COAD	chr16	30964109	Missense_Mutation	rs373130363	R219C	0.37
COAD	chr16	30965737	Missense_Mutation	rs767111251	A619V	0.42
COAD	chr16	30979180	Missense_Mutation	novel	R1132C	0.26
COAD	chr16	30980158	Missense_Mutation	NA	D1458Y	0.29
COAD	chr16	30965996	Frame_Shift_Del	NA	*G708Vfs95**	0.49
COAD	chr16	30983641	Missense_Mutation	novel	A1607T	0.53
COAD	chr16	30967013	Missense_Mutation	rs145597825	A879T	0.23
COAD	chr16	30971394	Silent	rs779225096	S1011S	0.29
COAD	chr16	30964255	Silent	rs747996167	S267S	0.42
COAD	chr16	30979235	Missense_Mutation	rs747056798	R1150H	0.4
COAD	chr16	30965649	Missense_Mutation	rs778146669	R590W	0.15
COAD	chr16	30971569	Missense_Mutation	rs776011822	R1070W	0.26
COAD	chr16	30979162	Frame_Shift_Del	novel	*S1128Vfs134**	0.25
COAD	chr16	30965996	Frame_Shift_Del	NA	*G708Vfs95**	0.39
COAD	chr16	30979362	Silent	NA	P1192P	0.39
COAD	chr16	30971437	Missense_Mutation	NA	E1026K	0.07
COAD	chr16	30979250	Frame_Shift_Ins	novel	*L1157Pfs90**	0.25
COAD	chr16	30964211	Nonsense_Mutation	novel	R253*	0.51
COAD	chr16	30983643	Silent	rs770747269	A1607A	0.29
COAD	chr16	30971502	Silent	NA	S1047S	0.44
COAD	chr16	30965807	Frame_Shift_Ins	NA	E645*	0.35
COAD	chr16	30979323	Silent	rs200527523	P1179P	0.38
COAD	chr16	30966171	Missense_Mutation	novel	V764I	0.1
COAD	chr16	30969369	Silent	rs766001323	D945D	0.21
COAD	chr16	30964916	Frame_Shift_Del	NA	*P393Lfs104**	0.2
DLBC	chr16	30965313	Missense_Mutation	novel	R524T	0.44
ESCA	chr16	30964637	Missense_Mutation	rs771239116	R299W	0.33
ESCA	chr16	30965177	Missense_Mutation	novel	S479C	0.3
GBM	chr16	30958862	Missense_Mutation	NA	G44E	0.27
GBM	chr16	30965065	Silent	NA	G441G	0.42
GBM	chr16	30965073	Missense_Mutation	novel	G444E	0.08
GBM	chr16	30965812	Missense_Mutation	NA	P644R	0.32
GBM	chr16	30961353	Missense_Mutation	novel	K111N	0.04	RRM_1
HNSC	chr16	30964655	Missense_Mutation	novel	Y305N	0.15
HNSC	chr16	30967536	Silent	novel	A906A	0.21
HNSC	chr16	30969628	Silent	novel	E985E	0.17
HNSC	chr16	30983732	Missense_Mutation	novel	K1637T	0.19
HNSC	chr16	30965946	Missense_Mutation	NA	R689W	0.22
HNSC	chr16	30963487	Missense_Mutation	novel	Q191R	0.62
HNSC	chr16	30965102	Missense_Mutation	novel	E454K	0.19
HNSC	chr16	30966200	Silent	novel	P773P	0.21
HNSC	chr16	30979306	Nonsense_Mutation	novel	E1174*	0.22
HNSC	chr16	30971436	Silent	rs768637479	G1025G	0.26
HNSC	chr16	30965414	Missense_Mutation	novel	E558K	0.28
HNSC	chr16	30979618	Missense_Mutation	novel	E1278Q	0.22
KICH	chr16	30979187	Missense_Mutation	novel	P1134R	0.11
KIRC	chr16	30966056	Silent	NA	A725A	0.17
KIRC	chr16	30979648	Missense_Mutation	NA	R1288S	0.17
KIRP	chr16	30958780	Missense_Mutation	NA	W17R	0.29
KIRP	chr16	30964965	Missense_Mutation	NA	S408Y	0.29
KIRP	chr16	30965117	Frame_Shift_Ins	novel	*R461Pfs18**	0.21
KIRP	chr16	30971635	Missense_Mutation	novel	V1092M	0.21
LAML	chr16	30971488	Missense_Mutation	novel	S1043A	0.08
LGG	chr16	30964912	Missense_Mutation	novel	E390D	0.28
LGG	chr16	30966068	Silent	rs772460629	P729P	0.4
LGG	chr16	30961264	Splice_Region	novel		0.14
LIHC	chr16	30965884	Missense_Mutation	NA	R668L	0.4
LIHC	chr16	30964736	Missense_Mutation	NA	A332T	0.37
LIHC	chr16	30979387	Missense_Mutation	rs774166831	R1201W	0.76
LUAD	chr16	30966004	Missense_Mutation	novel	G708V	0.33
LUAD	chr16	30961476	Silent	rs757785160	V152V	0.11
LUAD	chr16	30966177	Nonsense_Mutation	NA	G766*	0.56
LUAD	chr16	30979645	Missense_Mutation	novel	E1287Q	0.26
LUAD	chr16	30980181	Missense_Mutation	novel	W1465C	0.48
LUAD	chr16	30971625	Silent	rs370157586	T1088T	0.2
LUAD	chr16	30979713	Silent	NA	T1309T	0.44
LUAD	chr16	30965133	Missense_Mutation	NA	S464F	0.37
LUAD	chr16	30964813	Silent	novel	S357S	0.25
LUAD	chr16	30963522	Nonsense_Mutation	NA	K203*	0.44
LUAD	chr16	30963524	Missense_Mutation	NA	K203N	0.45
LUAD	chr16	30980572	Missense_Mutation	novel	Y1499C	0.2
LUAD	chr16	30980574	Missense_Mutation	novel	Y1500N	0.21
LUAD	chr16	30965987	Silent	novel	A702A	0.47
LUAD	chr16	30979518	Missense_Mutation	novel	E1244D	0.29
LUAD	chr16	30966115	Missense_Mutation	NA	R745L	0.22
LUAD	chr16	30979227	Silent	NA	P1147P	0.5
LUAD	chr16	30964275	Missense_Mutation	novel	T274K	0.28
LUAD	chr16	30980058	Missense_Mutation	novel	M1424I	0.21
LUAD	chr16	30979778	Missense_Mutation	NA	P1331L	0.33
LUSC	chr16	30965244	Missense_Mutation	novel	S501F	0.46
LUSC	chr16	30983660	Missense_Mutation	rs765554192	R1613H	0.25
LUSC	chr16	30964268	Missense_Mutation	NA	P272S	0.22
LUSC	chr16	30980627	Silent	rs2305882	S1517S	0.14
LUSC	chr16	30959095	Nonsense_Mutation	novel	S52*	0.13
LUSC	chr16	30965174	Nonsense_Mutation	novel	E478*	0.28
LUSC	chr16	30979713	Silent	NA	T1309T	0.15
LUSC	chr16	30971385	Silent	novel	D1008D	0.13
LUSC	chr16	30965010	Missense_Mutation	NA	Q423L	0.49
LUSC	chr16	30979669	Missense_Mutation	NA	H1295Y	0.36
LUSC	chr16	30979586	Missense_Mutation	NA	G1267E	0.4
LUSC	chr16	30967559	Missense_Mutation	NA	P914L	0.39
LUSC	chr16	30980087	Missense_Mutation	novel	G1434V	0.24
LUSC	chr16	30965921	Silent	NA	F680F	0.36
LUSC	chr16	30958850	Missense_Mutation	novel	Y40F	0.27
LUSC	chr16	30958846	Missense_Mutation	NA	V39M	0.08
LUSC	chr16	30969400	Missense_Mutation	rs150435865	R956C	0.24
LUSC	chr16	30979656	Missense_Mutation	novel	R1290S	0.28
LUSC	chr16	30969655	Silent	novel	V994V	0.45
LUSC	chr16	30980092	Missense_Mutation	novel	D1436Y	0.25
LUSC	chr16	30979762	Missense_Mutation	rs756711740	A1326T	0.39
LUSC	chr16	30961390	Missense_Mutation	novel	E124Q	0.07	RRM_1
LUSC	chr16	30965625	Missense_Mutation	novel	D582N	0.1
LUSC	chr16	30964880	Missense_Mutation	novel	T380P	0.21
MESO	chr16	30969429	Silent	novel	G965G	0.26
MESO	chr16	30979215	Frame_Shift_Del	novel	*A1144Pfs5**	0.15
OV	chr16	30983982	Missense_Mutation	novel	C1695G	0.22
OV	chr16	30964128	Missense_Mutation	NA	A225G	0.26
OV	chr16	30963554	Splice_Region	NA	T213T	0.39
OV	chr16	30965117	Frame_Shift_Ins	novel	*R461Pfs18**	0.21
OV	chr16	30965264	Missense_Mutation	novel	S508T	0.24
OV	chr16	30971643	Silent	NA	V1094V	0.26
OV	chr16	30971560	Nonsense_Mutation	NA	E1067*	0.55
OV	chr16	30979246	Missense_Mutation	NA	P1154A	0.5
OV	chr16	30971537	Missense_Mutation	NA	E1059G	0.42
OV	chr16	30983986	In_Frame_Ins	novel	L1696_C1697insK	0.05
OV	chr16	30981123	Missense_Mutation	novel	M1585I	0.21
OV	chr16	30984085	3'UTR	novel		0.17
OV	chr16	30981113	Missense_Mutation	novel	L1582R	0.24
OV	chr16	30965624	Silent	rs146323096	D581D	0.32
PAAD	chr16	30966245	Frame_Shift_Del	novel	*G789Hfs35**	0.24
PAAD	chr16	30967556	Missense_Mutation	rs771549718	R913H	0.05
PCPG	chr16	30971716	Missense_Mutation	rs763821551	A1119S	0.17
PRAD	chr16	30980026	Missense_Mutation	rs373025485	A1414T	0.33
PRAD	chr16	30980782	Missense_Mutation	novel	R1542L	0.42
READ	chr16	30969369	Silent	rs766001323	D945D	0.21
READ	chr16	30981107	Nonsense_Mutation	novel	W1580*	0.4
READ	chr16	30965996	Frame_Shift_Del	NA	*G708Vfs95**	0.38
READ	chr16	30980169	Silent	rs368388561	N1461N	0.3
READ	chr16	30983676	Silent	novel	G1618G	0.1
SARC	chr16	30980737	Splice_Site	rs755127868	X1528_splice	0.59
SARC	chr16	30965151	Missense_Mutation	novel	S470F	0.35
SARC	chr16	30965176	Silent	novel	E478E	0.25
SARC	chr16	30966982	Silent	novel	K868K	0.38
SKCM	chr16	30964820	Missense_Mutation	NA	R360C	0.38
SKCM	chr16	30969634	Missense_Mutation	NA	D987E	0.24
SKCM	chr16	30979196	Missense_Mutation	novel	P1137L	0.44
SKCM	chr16	30965832	Missense_Mutation	rs765710685	P651S	0.34
SKCM	chr16	30964884	Missense_Mutation	NA	S381F	0.4
SKCM	chr16	30979272	Silent	novel	K1162K	0.23
SKCM	chr16	30971672	Missense_Mutation	NA	P1104L	0.24
SKCM	chr16	30964788	Missense_Mutation	rs746239302	S349L	0.43
SKCM	chr16	30959166	Missense_Mutation	novel	L76F	0.21
SKCM	chr16	30964306	Silent	novel	D284D	0.5
SKCM	chr16	30964985	Missense_Mutation	novel	P415S	0.52
SKCM	chr16	30965118	Missense_Mutation	novel	S459F	0.16
SKCM	chr16	30969335	Missense_Mutation	novel	P934L	0.16
SKCM	chr16	30980522	Silent	novel	P1482P	0.21
SKCM	chr16	30959164	Missense_Mutation	NA	S75F	0.32
SKCM	chr16	30971405	Missense_Mutation	NA	S1015F	0.21
SKCM	chr16	30964185	Missense_Mutation	rs770463920	S244F	0.34
SKCM	chr16	30964820	Missense_Mutation	NA	R360C	0.44
SKCM	chr16	30965812	Missense_Mutation	NA	P644L	0.54
SKCM	chr16	30964671	Missense_Mutation	rs146035438	S310F	0.41
SKCM	chr16	30965651	Silent	novel	R590R	0.28
SKCM	chr16	30971492	Missense_Mutation	NA	S1044F	0.22
SKCM	chr16	30964688	Missense_Mutation	NA	A316S	0.34
SKCM	chr16	30965709	Missense_Mutation	novel	P610S	0.46
SKCM	chr16	30965710	Missense_Mutation	novel	P610L	0.48
SKCM	chr16	30965745	Missense_Mutation	novel	P622S	0.37
SKCM	chr16	30964954	Silent	NA	R404R	0.25
SKCM	chr16	30964930	Silent	novel	P396P	0.16
SKCM	chr16	30965439	Missense_Mutation	novel	P566L	0.23
SKCM	chr16	30966271	Missense_Mutation	NA	M797K	0.24
SKCM	chr16	30984050	3'UTR	novel		0.3
SKCM	chr16	30965024	Missense_Mutation	NA	P428S	0.14
SKCM	chr16	30980534	Silent	NA	P1486P	0.13
SKCM	chr16	30965902	Missense_Mutation	NA	G674A	0.27
SKCM	chr16	30965904	Missense_Mutation	NA	G675R	0.27
SKCM	chr16	30961485	Silent	NA	L155L	0.37
SKCM	chr16	30966964	Silent	rs779852305	S862S	0.45
SKCM	chr16	30969680	Missense_Mutation	NA	V1003L	0.28
SKCM	chr16	30980534	Silent	NA	P1486P	0.15
SKCM	chr16	30964671	Missense_Mutation	rs146035438	S310F	0.51
SKCM	chr16	30964884	Missense_Mutation	NA	S381F	0.15
SKCM	chr16	30966963	Missense_Mutation	NA	S862F	0.45
SKCM	chr16	30984014	Silent	NA	S1705S	0.33
SKCM	chr16	30965045	Missense_Mutation	NA	P435S	0.1
SKCM	chr16	30965253	Missense_Mutation	NA	S504F	0.41
SKCM	chr16	30964788	Missense_Mutation	rs746239302	S349L	0.6
SKCM	chr16	30965217	Missense_Mutation	novel	I492S	0.16
SKCM	chr16	30967529	Missense_Mutation	NA	S904F	0.9
SKCM	chr16	30963527	Silent	NA	F204F	0.34
STAD	chr16	30959147	Silent	NA	S69S	0.22
STAD	chr16	30965996	Frame_Shift_Del	NA	*G708Vfs95**	0.36
STAD	chr16	30979649	Missense_Mutation	rs772555919	R1288H	0.36
STAD	chr16	30979635	Silent	rs570770215	S1283S	0.13
STAD	chr16	30965807	Silent	rs777902844	P642P	0.16
STAD	chr16	30979331	Missense_Mutation	novel	P1182R	0.37
STAD	chr16	30971505	Silent	NA	S1048S	0.18
STAD	chr16	30979823	Missense_Mutation	rs778079685	A1346V	0.33
STAD	chr16	30980782	Missense_Mutation	rs755261245	R1542Q	0.31
STAD	chr16	30964821	Missense_Mutation	NA	R360H	0.27
STAD	chr16	30964674	Missense_Mutation	rs764044469	R311H	0.36
STAD	chr16	30981141	Silent	rs532298159	D1591D	0.37
STAD	chr16	30965127	Missense_Mutation	novel	P462Q	0.16
STAD	chr16	30979323	Silent	rs200527523	P1179P	0.21
STAD	chr16	30979713	Frame_Shift_Ins	novel	*A1312Cfs22**	0.12
STAD	chr16	30964990	Silent	NA	E416E	0.27
STAD	chr16	30971502	Silent	NA	S1047S	0.34
STAD	chr16	30971625	Silent	rs370157586	T1088T	0.19
STAD	chr16	30964916	Missense_Mutation	rs771871764	P392T	0.18
STAD	chr16	30964916	Frame_Shift_Del	NA	*P393Lfs104**	0.35
STAD	chr16	30966003	Missense_Mutation	NA	G708S	0.34
STAD	chr16	30971437	Missense_Mutation	NA	E1026K	0.24
STAD	chr16	30964814	Missense_Mutation	novel	Q358E	0.28
STAD	chr16	30964253	Frame_Shift_Del	novel	*S267Pfs230**	0.09
STAD	chr16	30958723	5'UTR	novel		0.15
STAD	chr16	30980116	Missense_Mutation	rs750790917	R1444W	0.25
STAD	chr16	30965996	Frame_Shift_Del	NA	*G708Vfs95**	0.31
STAD	chr16	30964176	Frame_Shift_Del	novel	*C243Afs254**	0.24
STAD	chr16	30966039	Frame_Shift_Del	novel	*P721Rfs82**	0.27
STAD	chr16	30979737	Silent	NA	P1317P	0.32
STAD	chr16	30965124	Missense_Mutation	NA	R461H	0.24
STAD	chr16	30958733	Translation_Start_Site	novel	M1?	0.34
STAD	chr16	30964724	Missense_Mutation	rs201145470	A328T	0.35
TGCT	chr16	30963455	Silent	novel	Y180Y	0.2
THCA	chr16	30980168	Missense_Mutation	rs771892048	N1461S	0.34
THYM	chr16	30961361	Missense_Mutation	novel	C114F	0.09	RRM_1
THYM	chr16	30971488	In_Frame_Del	rs777098458	S1058del	0.15
THYM	chr16	30971490	Silent	NA	S1043S	0.11
UCEC	chr16	30961413	Silent	rs368881858	T131T	0.51
UCEC	chr16	30966985	Silent	rs776505959	S869S	0.12
UCEC	chr16	30984464	3'UTR	novel		0.29
UCEC	chr16	30980584	Missense_Mutation	NA	S1503N	0.24
UCEC	chr16	30981094	Missense_Mutation	novel	R1576W	0.45
UCEC	chr16	30964998	Missense_Mutation	rs771940541	R419Q	0.53
UCEC	chr16	30965601	Missense_Mutation	novel	A574T	0.43
UCEC	chr16	30966936	Missense_Mutation	rs745926838	T853M	0.42
UCEC	chr16	30963442	Missense_Mutation	NA	R176Q	0.33
UCEC	chr16	30965873	Silent	NA	E664E	0.17
UCEC	chr16	30964661	Missense_Mutation	NA	D307Y	0.18
UCEC	chr16	30971485	In_Frame_Del	rs768655377	S1058del	0.42
UCEC	chr16	30964183	Silent	novel	C243C	0.18
UCEC	chr16	30971447	Missense_Mutation	novel	S1029I	0.22
UCEC	chr16	30964846	Silent	rs757732709	A368A	0.35
UCEC	chr16	30965916	Missense_Mutation	NA	S679P	0.46
UCEC	chr16	30961498	Missense_Mutation	novel	V160I	0.22	RRM_1
UCEC	chr16	30965074	Silent	novel	G444G	0.25
UCEC	chr16	30981155	Missense_Mutation	novel	E1596G	0.07
UCEC	chr16	30984104	3'UTR	novel		0.2
UCEC	chr16	30958853	Missense_Mutation	NA	R41H	0.24
UCEC	chr16	30964110	Missense_Mutation	rs772143385	R219H	0.35
UCEC	chr16	30971699	Missense_Mutation	rs199662660	A1113V	0.32
UCEC	chr16	30966004	Missense_Mutation	NA	G708A	0.28
UCEC	chr16	30965352	Missense_Mutation	NA	G537V	0.11
UCEC	chr16	30958770	Silent	rs149689471	P13P	0.45
UCEC	chr16	30971712	Silent	rs767546015	R1117R	0.36
UCEC	chr16	30961392	Missense_Mutation	novel	E124D	0.47	RRM_1
UCEC	chr16	30983717	Missense_Mutation	novel	I1632T	0.49
UCEC	chr16	30981080	Missense_Mutation	NA	R1571Q	0.48
UCEC	chr16	30971520	Silent	rs754761831	S1053S	0.36
UCEC	chr16	30983925	Missense_Mutation	NA	V1676M	0.39
UCEC	chr16	30984237	3'UTR	novel		0.5
UCEC	chr16	30966883	Splice_Site	novel	X836_splice	0.36
UCEC	chr16	30984232	3'UTR	novel		0.28
UCEC	chr16	30971700	Silent	rs751653700	A1113A	0.28
UCEC	chr16	30964662	Missense_Mutation	novel	D307A	0.16
UCEC	chr16	30967004	Missense_Mutation	novel	E876K	0.32
UCEC	chr16	30969312	Missense_Mutation	novel	E926D	0.19
UCEC	chr16	30984545	3'UTR	novel		0.41
UCEC	chr16	30981151	Missense_Mutation	novel	I1595V	0.32
UCEC	chr16	30984006	Silent	novel	R1703R	0.21
UCEC	chr16	30980152	Missense_Mutation	novel	G1456R	0.54
UCEC	chr16	30984410	3'UTR	novel		0.4
UCEC	chr16	30971394	Silent	rs779225096	S1011S	0.28
UCEC	chr16	30980127	Silent	rs140989531	Y1447Y	0.47
UCEC	chr16	30984034	3'UTR	novel		0.44
UCEC	chr16	30966204	Missense_Mutation	NA	E775K	0.31
UCEC	chr16	30984028	3'UTR	novel		0.57
UCEC	chr16	30966881	Splice_Region	novel		0.32
UCEC	chr16	30983985	Silent	NA	L1696L	0.25
UCEC	chr16	30980025	Silent	rs759173261	R1413R	0.21
UCEC	chr16	30964798	Silent	NA	S352S	0.37
UCEC	chr16	30966951	Missense_Mutation	novel	P858H	0.48
UCEC	chr16	30965202	Missense_Mutation	novel	S487N	0.15
UCEC	chr16	30965806	Missense_Mutation	rs769871463	P642L	0.72
UCEC	chr16	30963540	Missense_Mutation	novel	A209T	0.25
UCEC	chr16	30984083	3'UTR	novel		0.5
UCEC	chr16	30959157	Missense_Mutation	NA	D73Y	0.31
UCEC	chr16	30966239	Silent	NA	P786P	0.33
UCEC	chr16	30979290	Silent	novel	V1168V	0.22
UCEC	chr16	30965163	Missense_Mutation	NA	E474G	0.17
UCEC	chr16	30965843	Silent	rs370672157	P654P	0.39
UCEC	chr16	30979547	Missense_Mutation	rs368108050	A1254V	0.44
UCEC	chr16	30980833	Missense_Mutation	NA	K1559R	0.5
UCEC	chr16	30965195	Missense_Mutation	novel	H485Y	0.38
UCEC	chr16	30965286	Missense_Mutation	novel	E515V	0.44
UCEC	chr16	30969685	Silent	NA	S1004S	0.16
UCEC	chr16	30965347	Silent	NA	G535G	0.39
UCEC	chr16	30967004	Missense_Mutation	novel	E876K	0.38
UCS	chr16	30965995	Missense_Mutation	novel	G705D	0.23
UCS	chr16	30959112	Missense_Mutation	novel	E58K	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.0556	0.23475
COAD	AMP	0.2417	0.028297
LUAD	AMP	0.2519	0.20955
UCEC	AMP	0.0946	0.00057595

Survival Analysis

Cancer	P-value	Q-value
THYM	0.013	Kaplan-Meier Survival Analysis
KIRC	0.0041	Kaplan-Meier Survival Analysis
SKCM	0.041	Kaplan-Meier Survival Analysis
ESCA	0.00019	Kaplan-Meier Survival Analysis
PAAD	0.034	Kaplan-Meier Survival Analysis
CESC	0.027	Kaplan-Meier Survival Analysis
LIHC	0.0098	Kaplan-Meier Survival Analysis
UVM	0.023	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000099381 (Gene tree)
Gene ID: 9739
Gene Symbol: SETD1A
Alias: KIAA0339|Set1|KMT2F
Full Name: SET domain containing 1A, histone lysine methyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 36,160 bases
Position: chr16:30,948,505-30,984,664
Accession: 29010
RBP type: canonical RBP
Summary: The protein encoded by this gene is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to generally mark the transcription start sites of active genes. The protein contains SET domains, a RNA recognition motif domain and is a member of the class V-like SAM-binding methyltransferase superfamily. [provided by RefSeq, Dec 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000262519	RRM_1	PF00076.22	2.5e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29071121	Binding to RNA regulates Set1 function.	Cell Discov	2017 Oct 24	Luciano P	doi: 10.1038/celldisc.2017.40
19713935	Cotranslational assembly of the yeast SET1C histone methyltransferase complex.	EMBO J	2009 Oct 7	Halbach A	doi: 10.1038/emboj.2009.240
25356590	Multifaceted genome control by Set1 Dependent and Independent of H3K4 methylation and the Set1C/COMPASS complex.	PLoS Genet	2014 Oct 30	Mikheyeva IV	doi: 10.1371/journal.pgen.1004740
28483910	RNA Binding by Histone Methyltransferases Set1 and Set2.	Mol Cell Biol	2017 Jun 29	Sayou C	doi: 10.1128/MCB.00165-17
18765639	BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression.	Mol Cell Biol	2008 Nov	Nguyen P	doi: 10.1128/MCB.00568-08
21646424	Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter.	Mol Cell Biol	2011 Aug	Wang SS	doi: 10.1128/MCB.05017-11
29129639	Determinants of Histone H3K4 Methylation Patterns.	Mol Cell	2017 Nov 16	Soares LM	doi: 10.1016/j.molcel.2017.10.013

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000452917	SETD1A-202	315	-	ENSP00000391408	63 (aa)	-	C9J2Z9
ENST00000262519	SETD1A-201	6451	XM_005255723	ENSP00000262519	1707 (aa)	XP_005255780	O15047
ENST00000640410	SETD1A-203	718	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000099381's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00310	Lysine degradation	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000099381	rs67517081	16	30976060	G	Mean corpuscular hemoglobin	27863252	[0.018-0.032] unit decrease	0.02491798	EFO_0004527
ENSG00000099381	rs62055866	16	30958236	C	Neurociticism	29500382	z score increase	6.29	EFO_0007660
ENSG00000099381	rs7204459	16	30972891	?	Red blood cell count	30595370			EFO_0004305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000099381's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000099381	SETD1A	65	69.649	ENSAPLG00000005217	SETD1B	53	70.530	Anas_platyrhynchos
ENSG00000099381	SETD1A	100	91.953	ENSBTAG00000002345	SETD1A	100	92.177	Bos_taurus
ENSG00000099381	SETD1A	100	96.431	ENSCJAG00000003000	SETD1A	100	96.431	Callithrix_jacchus
ENSG00000099381	SETD1A	100	91.953	ENSCAFG00000016758	SETD1A	100	91.953	Canis_familiaris
ENSG00000099381	SETD1A	100	92.258	ENSCAFG00020018051	SETD1A	100	92.258	Canis_lupus_dingo
ENSG00000099381	SETD1A	100	92.267	ENSCHIG00000025896	SETD1A	100	92.236	Capra_hircus
ENSG00000099381	SETD1A	100	92.213	ENSCPOG00000025456	SETD1A	100	92.213	Cavia_porcellus
ENSG00000099381	SETD1A	100	95.902	ENSCCAG00000025600	SETD1A	100	95.960	Cebus_capucinus
ENSG00000099381	SETD1A	100	97.602	ENSCATG00000035417	SETD1A	100	97.602	Cercocebus_atys
ENSG00000099381	SETD1A	100	90.946	ENSCLAG00000011583	SETD1A	100	98.381	Chinchilla_lanigera
ENSG00000099381	SETD1A	100	97.834	ENSCSAG00000005791	SETD1A	100	97.834	Chlorocebus_sabaeus
ENSG00000099381	SETD1A	100	89.108	ENSCGRG00001022425	-	100	88.651	Cricetulus_griseus_chok1gshd
ENSG00000099381	SETD1A	100	89.166	ENSCGRG00000016965	-	100	88.709	Cricetulus_griseus_crigri
ENSG00000099381	SETD1A	100	93.626	ENSFCAG00000002588	SETD1A	100	93.275	Felis_catus
ENSG00000099381	SETD1A	70	69.707	ENSFHEG00000013126	setd1ba	51	69.205	Fundulus_heteroclitus
ENSG00000099381	SETD1A	100	97.715	ENSGGOG00000016052	SETD1A	100	97.715	Gorilla_gorilla
ENSG00000099381	SETD1A	100	94.438	ENSSTOG00000005369	SETD1A	100	94.321	Ictidomys_tridecemlineatus
ENSG00000099381	SETD1A	100	90.568	ENSLAFG00000023335	SETD1A	100	90.744	Loxodonta_africana
ENSG00000099381	SETD1A	100	97.778	ENSMFAG00000003435	SETD1A	100	97.778	Macaca_fascicularis
ENSG00000099381	SETD1A	100	97.251	ENSMMUG00000003233	SETD1A	100	99.595	Macaca_mulatta
ENSG00000099381	SETD1A	100	97.367	ENSMLEG00000030176	SETD1A	100	97.367	Mandrillus_leucophaeus
ENSG00000099381	SETD1A	100	93.732	ENSMICG00000001575	SETD1A	100	93.732	Microcebus_murinus
ENSG00000099381	SETD1A	100	89.057	ENSMOCG00000012528	-	100	89.587	Microtus_ochrogaster
ENSG00000099381	SETD1A	100	89.766	ENSPPRG00000012737	SETD1A	100	89.357	Panthera_pardus
ENSG00000099381	SETD1A	100	99.531	ENSPTRG00000008024	SETD1A	100	99.531	Pan_troglodytes
ENSG00000099381	SETD1A	100	97.427	ENSPANG00000025141	SETD1A	100	97.427	Papio_anubis
ENSG00000099381	SETD1A	100	88.355	ENSPEMG00000024243	-	100	96.341	Peromyscus_maniculatus_bairdii
ENSG00000099381	SETD1A	100	93.263	ENSPCOG00000020896	SETD1A	100	93.204	Propithecus_coquereli
ENSG00000099381	SETD1A	100	89.108	ENSRNOG00000055028	Setd1a	100	88.812	Rattus_norvegicus
ENSG00000099381	SETD1A	100	94.746	ENSSBOG00000020392	SETD1A	100	95.213	Saimiri_boliviensis_boliviensis
ENSG00000099381	SETD1A	56	98.119	ENSSSCG00000007782	SETD1A	95	98.089	Sus_scrofa
ENSG00000099381	SETD1A	58	68.810	ENSTNIG00000009090	setd1ba	53	68.954	Tetraodon_nigroviridis
ENSG00000099381	SETD1A	100	92.267	ENSTTRG00000015493	SETD1A	100	92.150	Tursiops_truncatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000790	nuclear chromatin	27141965.	IDA	Component
GO:0003723	RNA binding	-	IEA	Function
GO:0005515	protein binding	12670868.17998332.18765639.20622854.22723415.22843687.23870121.26886794.	IPI	Function
GO:0005634	nucleus	17500065.	IDA	Component
GO:0005634	nucleus	22723415.	IMP	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0008013	beta-catenin binding	22723415.	IDA	Function
GO:0008134	transcription factor binding	27141965.	IPI	Function
GO:0016607	nuclear speck	-	IDA	Component
GO:0035097	histone methyltransferase complex	17355966.17500065.	IDA	Component
GO:0042800	histone methyltransferase activity (H3-K4 specific)	20862685.	IDA	Function
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0048188	Set1C/COMPASS complex	17998332.18838538.	IDA	Component
GO:0048188	Set1C/COMPASS complex	27141965.	TAS	Component
GO:0051568	histone H3-K4 methylation	-	IEA	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	27141965.	IDA	Process
GO:1902275	regulation of chromatin organization	27141965.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.