EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24389200	Downregulation of CRKL expression can inhibit tumorigenesis in colon cancer.	Front Biosci (Landmark Ed)	2014 Jan 1	Lan B	-
25476480	CrkL regulates SDF-1-induced breast cancer biology through balancing Erk1/2 and PI3K/Akt pathways.	Med Oncol	2015 Jan	Lian X	doi: 10.1007/s12032-014-0411-z
21700719	CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer.	Mol Endocrinol	2011 Sep	Padmanabhan RA	doi: 10.1210/me.2011-0008
25318601	CRKL protein overexpression enhances cell proliferation and invasion in pancreatic cancer.	Tumour Biol	2015 Feb	Fu L	doi: 10.1007/s13277-014-2706-2
22591714	The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer.	J Transl Med	2012 Jul 3	Natsume H	doi: 10.1186/1479-5876-10-97.
27133071	The effects of Micro-429 on inhibition of cervical cancer cells through targeting ZEB1 and CRKL.	Biomed Pharmacother	2016 May	Wang Y	doi: 10.1016/j.biopha.2016.03.035
22569336	Crk adaptor proteins act as key signaling integrators for breast tumorigenesis.	Breast Cancer Res	2012 May 8	Fathers KE	-
19966867	Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer.	Oncogene	2010 Mar 11	Kim YH	doi: 10.1038/onc.2009.437
24375195	Clinical significance and biological roles of CRKL in human bladder carcinoma.	Tumour Biol	2014 May	Han B	doi: 10.1007/s13277-013-1536-y
24939008	CRKL amplification is rare as a mechanism for acquired resistance to kinase inhibitors in lung cancers with epidermal growth factor receptor mutation.	Lung Cancer	2014 Aug	Suda K	doi: 10.1016/j.lungcan.2014.05.018
26044596	CrkL meditates CCL20/CCR6-induced EMT in gastric cancer.	Cytokine	2015 Dec	Han G	doi: 10.1016/j.cyto.2015.05.009
21319228	Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma.	Mol Carcinog	2011 Jul	Wang J	doi: 10.1002/mc.20745
27846244	SLC7A5 Functions as a Downstream Target Modulated by CRKL in Metastasis Process of Gastric Cancer SGC-7901 Cells.	PLoS One	2016 Nov 15	Wang J	doi: 10.1371/journal.pone.0166147
27078848	CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma.	Oncotarget	2016 May 17	An R	doi: 10.18632/oncotarget.8638.
28723560	CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.	Cell Rep	2017 Jul 18	Zhang J	doi: 10.1016/j.celrep.2017.06.054.
29295725	MicroRNA-379 Suppresses Cervical Cancer Cell Proliferation and Invasion by Directly Targeting V-crk Avian Sarcoma Virus CT10 Oncogene Homolog-Like (CRKL).	Oncol Res	2018 Aug 23	Shi X	doi: 10.3727/096504017X15140534417184

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr22	20949858	3'UTR	novel		0.08
BLCA	chr22	20917995	Missense_Mutation	novel	R21C	0.43
BLCA	chr22	20918015	Silent	NA	R27R	0.22
BRCA	chr22	20949773	Silent	rs769606385	N280N	0.09
BRCA	chr22	20957451	3'Flank	novel		0.25
BRCA	chr22	20949919	3'UTR	novel		0.15
BRCA	chr22	20918008	Missense_Mutation	NA	Q25R	0.61
CESC	chr22	20952500	3'UTR	novel		0.31
CESC	chr22	20918075	Frame_Shift_Del	novel	*Y48Cfs101**	0.07
CESC	chr22	20933810	Missense_Mutation	novel	A115S	0.41
COAD	chr22	20933810	Missense_Mutation	novel	A115T	0.1
COAD	chr22	20949778	Missense_Mutation	novel	R282H	0.26
COAD	chr22	20918070	Missense_Mutation	NA	G46W	0.23
COAD	chr22	20934081	Missense_Mutation	NA	H205R	0.27
COAD	chr22	20933901	Missense_Mutation	NA	K145T	0.26
DLBC	chr22	20934127	Silent	rs763765173	S220S	0.4
ESCA	chr22	20918211	Silent	novel	L93L	0.29
GBM	chr22	20934033	Missense_Mutation	novel	K189R	0.03
HNSC	chr22	20918231	Missense_Mutation	novel	I99M	0.64
HNSC	chr22	20949765	Missense_Mutation	NA	E278K	0.07
KIRP	chr22	20950019	3'UTR	novel		0.31
KIRP	chr22	20917971	Missense_Mutation	NA	A13P	0.18
LGG	chr22	20934083	Missense_Mutation	novel	A206T	0.42
LGG	chr22	20949800	Silent	NA	T289T	0.04
LUAD	chr22	20934139	Silent	novel	G224G	0.27
LUAD	chr22	20934140	Missense_Mutation	novel	A225S	0.27
LUAD	chr22	20918172	Missense_Mutation	novel	H80D	0.22
LUAD	chr22	20933858	Missense_Mutation	NA	L131V	0.11
LUSC	chr22	20933915	Silent	NA	L150L	0.23
LUSC	chr22	20934238	Silent	NA	A257A	0.27
LUSC	chr22	20934098	Missense_Mutation	NA	Q211E	0.29
PAAD	chr22	20933884	Silent	novel	A139A	0.06
READ	chr22	20934169	Silent	NA	Q234Q	0.21
READ	chr22	20934187	Silent	rs755185083	A240A	0.43
READ	chr22	20949765	Missense_Mutation	NA	E278K	0.15
SKCM	chr22	20949792	Missense_Mutation	novel	P287S	0.34
SKCM	chr22	20933836	Silent	novel	D123D	0.19
SKCM	chr22	20933934	Missense_Mutation	NA	P156L	0.35
SKCM	chr22	20933965	Silent	novel	K166K	0.14
SKCM	chr22	20918025	Nonsense_Mutation	novel	Q31*	0.21
STAD	chr22	20933879	Missense_Mutation	NA	D138Y	0.42
STAD	chr22	20933958	Missense_Mutation	rs200712124	R164Q	0.13
STAD	chr22	20949773	Silent	rs769606385	N280N	0.34
STAD	chr22	20933791	Silent	NA	P108P	0.08
STAD	chr22	20918187	Silent	rs774677048	L85L	0.22
THCA	chr22	20950043	3'UTR	novel		0.17
UCEC	chr22	20933928	Frame_Shift_Ins	novel	*E158Afs2**	0.08
UCEC	chr22	20934000	Missense_Mutation	novel	V178A	0.15
UCEC	chr22	20952482	3'UTR	novel		0.19
UCEC	chr22	20949765	Missense_Mutation	NA	E278K	0.29
UCEC	chr22	20934001	Silent	rs752182830	V178V	0.44
UCEC	chr22	20952996	3'UTR	rs749055960		0.47
UCEC	chr22	20953202	3'UTR	novel		0.48
UCEC	chr22	20953711	3'UTR	novel		0.56
UCEC	chr22	20934138	Missense_Mutation	NA	G224V	0.47
UCEC	chr22	20953510	3'UTR	novel		0.22
UCEC	chr22	20934029	Missense_Mutation	rs746219908	G188R	0.45
UCEC	chr22	20949805	Missense_Mutation	novel	V291A	0.42
UCEC	chr22	20917901	5'UTR	novel		0.48
UCEC	chr22	20933840	Missense_Mutation	NA	L125M	0.24
UCEC	chr22	20949854	3'UTR	novel		0.17
UCEC	chr22	20950051	3'UTR	novel		0.37
UCEC	chr22	20952481	3'UTR	rs189984591		0.18
UCEC	chr22	20953581	3'UTR	novel		0.49
UCEC	chr22	20949800	Silent	NA	T289T	0.25
UCEC	chr22	20934100	Missense_Mutation	novel	Q211H	0.39
UCEC	chr22	20950031	3'UTR	rs772959264		0.56
UCEC	chr22	20952925	3'UTR	novel		0.42
UCEC	chr22	20917993	Missense_Mutation	novel	S20F	0.33
UCEC	chr22	20918019	Nonsense_Mutation	NA	Q29*	0.56
UCEC	chr22	20950051	3'UTR	novel		0.31
UCEC	chr22	20934153	Missense_Mutation	novel	P229H	0.5
UCEC	chr22	20952337	3'UTR	novel		0.73
UCEC	chr22	20949800	Silent	NA	T289T	0.33
UCEC	chr22	20949804	Missense_Mutation	novel	V291I	0.28
UCEC	chr22	20952367	3'UTR	novel		0.3
UCEC	chr22	20952671	3'UTR	novel		0.36
UCEC	chr22	20953215	3'UTR	novel		0.37
UCEC	chr22	20949800	Silent	NA	T289T	0.31
UCEC	chr22	20933841	Missense_Mutation	novel	L125P	0.34
UCEC	chr22	20933782	Nonsense_Mutation	novel	Y105*	0.19
UCEC	chr22	20949773	Silent	rs769606385	N280N	0.13
UCEC	chr22	20934001	Silent	rs752182830	V178V	0.21
UCEC	chr22	20949799	Missense_Mutation	NA	T289M	0.3
UCEC	chr22	20933934	Missense_Mutation	NA	P156H	0.33
UCEC	chr22	20933834	Missense_Mutation	novel	D123Y	0.27
UCEC	chr22	20953158	3'UTR	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LUSC	AMP	0.3892	2.9109e-05
LUSC	DEL	0.1178	0.0093511
TGCT	AMP	0.3533	5.309e-06
THCA	AMP	0.008	0.056221

Survival Analysis

Cancer	P-value	Q-value
THYM	0.016	Kaplan-Meier Survival Analysis
KIRC	0.023	Kaplan-Meier Survival Analysis
STAD	0.02	Kaplan-Meier Survival Analysis
SARC	0.032	Kaplan-Meier Survival Analysis
ACC	0.0026	Kaplan-Meier Survival Analysis
SKCM	0.044	Kaplan-Meier Survival Analysis
KIRP	0.0037	Kaplan-Meier Survival Analysis
BLCA	0.016	Kaplan-Meier Survival Analysis
READ	0.0057	Kaplan-Meier Survival Analysis
LAML	0.049	Kaplan-Meier Survival Analysis
KICH	0.037	Kaplan-Meier Survival Analysis
UCEC	0.029	Kaplan-Meier Survival Analysis
LIHC	0.024	Kaplan-Meier Survival Analysis
LGG	0.00048	Kaplan-Meier Survival Analysis
UVM	0.049	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000099942 (Gene tree)
Gene ID: 1399
Gene Symbol: CRKL
Alias: N
Full Name: CRK like proto-oncogene, adaptor protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 36,352 bases
Position: chr22:20,917,398-20,953,749
Accession: 2363
RBP type: non-canonical RBP
Summary: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000411769	CRKL-202	2037	-	ENSP00000396646	303 (aa)	-	P46109
ENST00000354336	CRKL-201	5325	-	ENSP00000346300	303 (aa)	-	P46109

Gene Model

Click here to download ENSG00000099942's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04010	MAPK signaling pathway	KEGG
hsa04012	ErbB signaling pathway	KEGG
hsa04015	Rap1 signaling pathway	KEGG
hsa04062	Chemokine signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa04666	Fc gamma R-mediated phagocytosis	KEGG
hsa04722	Neurotrophin signaling pathway	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa05100	Bacterial invasion of epithelial cells	KEGG
hsa05131	Shigellosis	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05206	MicroRNAs in cancer	KEGG
hsa05211	Renal cell carcinoma	KEGG
hsa05220	Chronic myeloid leukemia	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000099942	rs139459946	22	20925144	T	Platelet distribution width	27863252	[0.13-0.23] unit decrease	0.1828325	EFO_0007984

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000099942's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000186	activation of MAPKK activity	-	TAS	Process
GO:0000187	activation of MAPK activity	-	IEA	Process
GO:0001558	regulation of cell growth	-	IEA	Process
GO:0001568	blood vessel development	-	IEA	Process
GO:0001655	urogenital system development	-	IEA	Process
GO:0001764	neuron migration	-	IEA	Process
GO:0001783	B cell apoptotic process	-	IEA	Process
GO:0001784	phosphotyrosine residue binding	20624904.	IPI	Function
GO:0001933	negative regulation of protein phosphorylation	23959425.	IMP	Process
GO:0001934	positive regulation of protein phosphorylation	23959425.	IMP	Process
GO:0003151	outflow tract morphogenesis	-	IEA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005070	SH3/SH2 adaptor activity	8798523.	TAS	Function
GO:0005515	protein binding	8626543.9546424.9788432.10022120.16273093.16284401.16443220.16982329.17065230.19004829.19168626.22286129.23397142.23770091.24658140.24728074.25241761.25814554.26496610.28086240.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006629	lipid metabolic process	-	IEA	Process
GO:0007254	JNK cascade	8798523.	TAS	Process
GO:0007265	Ras protein signal transduction	8798523.	TAS	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0007338	single fertilization	-	IEA	Process
GO:0007416	synapse assembly	-	IEA	Process
GO:0008284	positive regulation of cell proliferation	25540073.	IMP	Process
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IEA	Process
GO:0008584	male gonad development	-	IEA	Process
GO:0009952	anterior/posterior pattern specification	-	IEA	Process
GO:0010629	negative regulation of gene expression	23959425.	IMP	Process
GO:0016358	dendrite development	-	IEA	Process
GO:0019221	cytokine-mediated signaling pathway	-	TAS	Process
GO:0021766	hippocampus development	-	IEA	Process
GO:0021987	cerebral cortex development	-	IEA	Process
GO:0030010	establishment of cell polarity	-	IEA	Process
GO:0031594	neuromuscular junction	-	IEA	Component
GO:0032991	protein-containing complex	-	IEA	Component
GO:0033628	regulation of cell adhesion mediated by integrin	-	IEA	Process
GO:0035556	intracellular signal transduction	8361759.	TAS	Process
GO:0035685	helper T cell diapedesis	-	IEA	Process
GO:0038026	reelin-mediated signaling pathway	-	IEA	Process
GO:0042802	identical protein binding	17161365.19168626.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046579	positive regulation of Ras protein signal transduction	-	TAS	Process
GO:0048384	retinoic acid receptor signaling pathway	-	IEA	Process
GO:0048538	thymus development	-	IEA	Process
GO:0050773	regulation of dendrite development	-	IEA	Process
GO:0050852	T cell receptor signaling pathway	-	IEA	Process
GO:0060017	parathyroid gland development	-	IEA	Process
GO:0060326	cell chemotaxis	-	IEA	Process
GO:0060465	pharynx development	-	IEA	Process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	23959425.	IMP	Process
GO:0071560	cellular response to transforming growth factor beta stimulus	23959425.	IMP	Process
GO:0086100	endothelin receptor signaling pathway	-	IEA	Process
GO:0090630	activation of GTPase activity	-	IEA	Process
GO:0095500	acetylcholine receptor signaling pathway	-	IEA	Process
GO:0098749	cerebellar neuron development	-	IEA	Process
GO:0098761	cellular response to interleukin-7	-	IEA	Process
GO:0098890	extrinsic component of postsynaptic membrane	-	IEA	Component
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	19004829.	IMP	Process
GO:1903977	positive regulation of glial cell migration	23959425.	IMP	Process
GO:1904393	regulation of skeletal muscle acetylcholine-gated channel clustering	-	IEA	Process
GO:1904888	cranial skeletal system development	-	IEA	Process
GO:2000404	regulation of T cell migration	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.