| 16820947 | Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways. | Int J Mol Med | 2006 Aug | Uemura Y | - |
| 20009539 | Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models. | Cancer Biol Ther | 2009 Oct | Chang Q | - |
| 24128853 | CR108, a novel vitamin K3 derivative induces apoptosis and breast tumor inhibition by reactive oxygen species and mitochondrial dysfunction. | Toxicol Appl Pharmacol | 2013 Dec 15 | Yang CR | doi: 10.1016/j.taap.2013.10.007 |
| 27456359 | Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer. | Tumour Biol | 2016 Oct | Starska K | - |
| 17149612 | Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. | Virchows Arch | 2007 Feb | Schmitz KJ | - |
| 15243131 | Mechanisms regulating the constitutive activation of the extracellular signal-regulated kinase (ERK) signaling pathway in ovarian cancer and the effect of ribonucleic acid interference for ERK1/2 on cancer cell proliferation. | Mol Endocrinol | 2004 Oct | Steinmetz R | - |
| 22696230 | Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. | Clin Cancer Res | 2012 Aug 1 | Chung LY | - |
| 27356628 | MicroRNA335 inhibits bladder cancer cell growth and migration by targeting mitogenactivated protein kinase1. | Mol Med Rep | 2016 Aug | Wang X | doi: 10.3892/mmr.2016.5448 |
| 27223086 | Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling. | Oncotarget | 2016 Jun 28 | Liu Y | doi: 10.18632/oncotarget.9512. |
| 29550487 | MicroRNA-585 suppresses tumor proliferation and migration in gastric cancer by directly targeting MAPK1. | Biochem Biophys Res Commun | 2018 Apr 30 | Hu L | doi: 10.1016/j.bbrc.2018.03.116 |
| 12774925 | Constitutive activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in B-cell lymphoproliferative disorders. | Int J Hematol | 2003 May | Ogasawara T | - |
| 25341684 | SKLB-M8 induces apoptosis through the AKT/mTOR signaling pathway in melanoma models and inhibits angiogenesis with decrease of ERK1/2 phosphorylation. | J Pharmacol Sci | 2014 | Wang J | - |
| 19729990 | Signaling pathways in adenoid cystic cancers: implications for treatment. | Cancer Biol Ther | 2009 Oct | Gupta AK | - |
| 24619413 | The mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cells. | J Biol Chem | 2014 Apr 18 | Ma B | doi: 10.1074/jbc.M113.540237 |
| 27085460 | Induction of integrin β3 by sustained ERK activity promotes the invasiveness of TGFβ-induced mesenchymal tumor cells. | Cancer Lett | 2016 Jul 1 | Hong SK | doi: 10.1016/j.canlet.2016.04.012 |
| 12937136 | Extra-cellular signal-regulated ERK-1/ERK-2 pathway activation in human salivary gland mucoepidermoid carcinoma: association to aggressive tumor behavior and tumor cell proliferation. | Am J Pathol | 2003 Sep | Handra-Luca A | - |
| 14985328 | Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. | J Biol Chem | 2004 May 7 | Catalano S | - |
| 23250869 | A MicroRNA196a2* and TP63 circuit regulated by estrogen receptor-α and ERK2 that controls breast cancer proliferation and invasiveness properties. | Horm Cancer | 2013 Apr | Kim K | doi: 10.1007/s12672-012-0129-3 |
| 22521293 | ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells. | Life Sci | 2012 Oct 15 | von Brandenstein M | doi: 10.1016/j.lfs.2012.04.014 |
| 12883725 | P38 MAPK pathway is involved in the urokinase plasminogen activator expression in human gastric SNU-638 cells. | Oncol Rep | 2003 Sep-Oct | Shin BA | - |
| 19941816 | EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. | Mol Cell | 2009 Nov 25 | Ji H | doi: 10.1016/j.molcel.2009.09.034. |
| 26267534 | Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. | Cancer Cell | 2015 Aug 10 | Herrero A | doi: 10.1016/j.ccell.2015.07.001. |
| 18509361 | Lack of cytoplasmic ERK activation is an independent adverse prognostic factor in primary cutaneous melanoma. | J Invest Dermatol | 2008 Nov | Jovanovic B | doi: 10.1038/jid.2008.134 |
| 11884401 | Protein kinase C and ERK activation are required for TFF-peptide-stimulated bronchial epithelial cell migration and tumor necrosis factor-alpha-induced interleukin-6 (IL-6) and IL-8 secretion. | J Biol Chem | 2002 May 24 | Graness A | - |
| 22345558 | Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. | Proc Natl Acad Sci U S A | 2012 Mar 13 | Park MC | doi: 10.1073/pnas.1200194109 |
| 17510316 | Down-regulation of Sprouty2 in non-small cell lung cancer contributes to tumor malignancy via extracellular signal-regulated kinase pathway-dependent and -independent mechanisms. | Mol Cancer Res | 2007 May | Sutterl??ty H | - |
| 19484147 | Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling. | Neoplasia | 2009 Jun | Neiva KG | - |
| 23674093 | Extracellular signal-regulated kinase 2 mediates the expression of granulocyte colony-stimulating factor in invasive cancer cells. | Oncol Rep | 2013 Jul | Lee CH | doi: 10.3892/or.2013.2463 |
| 28007785 | p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis. | Genes Dev | 2016 Dec 1 | Brichkina A | doi: 10.1101/gad.290346.116. |
| 28315433 | Increased semaphorin 3c expression promotes tumor growth and metastasis in pancreatic ductal adenocarcinoma by activating the ERK1/2 signaling pathway. | Cancer Lett | 2017 Jul 1 | Xu X | doi: 10.1016/j.canlet.2017.03.014 |
| 26686085 | Tumor-suppressor NF??B2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494. | Oncogene | 2016 Aug 4 | Wang Y | doi: 10.1038/onc.2015.470 |
| 28114280 | RARRES2 functions as a tumor suppressor by promoting β-catenin phosphorylation/degradation and inhibiting p38 phosphorylation in adrenocortical carcinoma. | Oncogene | 2017 Jun 22 | Liu-Chittenden Y | doi: 10.1038/onc.2016.497 |
| 27760319 | Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants. | Cell Rep | 2016 Oct 18 | Brenan L | doi: 10.1016/j.celrep.2016.09.061. |
| 29382922 | ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients. | Lab Invest | 2018 May | Zhou H | doi: 10.1038/s41374-018-0022-y |
| 27780136 | Pro-survival effects by NF-??B, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer. | Biomed Pharmacother | 2016 Dec | Yang J | doi: 10.1016/j.biopha.2016.10.028 |
| 26785721 | Hypoxia regulates ABCG2 activity through the activivation of ERK1/2/HIF-1αand contributes to chemoresistance in pancreatic cancer cells. | Cancer Biol Ther | 2016 | He X | doi: 10.1080/15384047.2016.1139228 |
| 22672288 | Significance of decoy receptor 3 (Dcr3) and external-signal regulated kinase 1/2 (Erk1/2) in gastric cancer. | BMC Immunol | 2012 Jun 6 | Yang D | - |
| 17631144 | Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells. | Gastroenterology | 2007 Jul | Zhu F | - |
| 17825787 | LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. | Biochem Biophys Res Commun | 2007 Nov 9 | Zhao L | - |
| 25962735 | Ginkgo biloba extract enhances chemotherapy sensitivity and reverses chemoresistance through suppression of the KSR1-mediated ERK1/2 pathway in gastric cancer cells. | Oncol Rep | 2015 Jun | Liu SQ | doi: 10.3892/or.2015.3923 |
| 26253279 | Action of methyl-, propyl- and butylparaben on GPR30 gene and protein expression, cAMP levels and activation of ERK1/2 and PI3K/Akt signaling pathways in MCF-7 breast cancer cells and MCF-10A non-transformed breast epithelial cells. | Toxicol Lett | 2015 Oct 14 | Wr??bel AM | doi: 10.1016/j.toxlet.2015.08.001 |
| 25120769 | Expression of aquaporin 8 and phosphorylation of Erk1/2 in cervical epithelial carcinogenesis: correlation with clinicopathological parameters. | Int J Clin Exp Pathol | 2014 Jun 15 | Chang H | - |
| 21424124 | Inhibition of the p38 MAPK pathway sensitises human colon cancer cells to 5-fluorouracil treatment. | Int J Oncol | 2011 Jun | Yang SY | doi: 10.3892/ijo.2011.982 |
| 23357054 | Two initiation sites of early detection of colon cancer revealed by localization of pERK1/2 in the nuclei or in aggregates at the perinuclear region of the tumor cells. | Acta Histochem | 2013 Jul | Amsterdam A | doi: 10.1016/j.acthis.2012.12.006 |
| 26176534 | Pro-Inflammatory Cytokine IL-1β Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma. | PLoS One | 2015 Jul 15 | Sun Y | doi: 10.1371/journal.pone.0132677 |
| 23183114 | High nuclear expression of phosphorylated extracellular signal-regulated kinase in tumor cells in colorectal glands is associated with poor outcome in colorectal cancer. | Ann Diagn Pathol | 2013 Apr | Tai CJ | doi: 10.1016/j.anndiagpath.2012.09.004 |
| 24752576 | AQP5 silencing suppresses p38 MAPK signaling and improves drug resistance in colon cancer cells. | Tumour Biol | 2014 Jul | Shi X | doi: 10.1007/s13277-014-1956-3 |
| 18570890 | Constitutive hypophosphorylation of extracellular signal-regulated kinases-1/2 and down-regulation of c-Jun in human gastric adenocarcinoma. | Biochem Biophys Res Commun | 2008 Aug 22 | Wu WK | doi: 10.1016/j.bbrc.2008.06.025 |
| 28435071 | ER-α36 mediates estrogen-stimulated MAPK/ERK activation and regulates migration, invasion, proliferation in cervical cancer cells. | Biochem Biophys Res Commun | 2017 Jun 3 | Sun Q | doi: 10.1016/j.bbrc.2017.04.105 |
| 28328092 | Neferine Enhances the Antitumor Effect of Mitomycin-C in Hela Cells Through the Activation of p38-MAPK Pathway. | J Cell Biochem | 2017 Oct | Eid W | doi: 10.1002/jcb.26006 |
| 29196260 | Advanced glycation end products promote triple negative breast cancer cells via ERK and NF-??B pathway. | Biochem Biophys Res Commun | 2018 Jan 15 | Lee KJ | doi: 10.1016/j.bbrc.2017.11.182 |
| 28396058 | Connexin43high prostate cancer cells induce endothelial connexin43 up-regulation through the activation of intercellular ERK1/2-dependent signaling axis. | Eur J Cell Biol | 2017 Jun | Piwowarczyk K | doi: 10.1016/j.ejcb.2017.03.012 |
| 29039608 | Livin promotes the progression and metastasis of breast cancer through the regulation of epithelialmesenchymal transition via the p38/GSK3β pathway. | Oncol Rep | 2017 Dec | Han Y | doi: 10.3892/or.2017.6017 |
| 18813840 | ERK2 CD domain mutation from a human cancer cell line enhanced anchorage-independent cell growth and abnormality in Drosophila. | Oncol Rep | 2008 Oct | Mahalingam M | - |
| 22864777 | Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer. | Pol J Pathol | 2012 Jun | Tai CJ | - |
| 22293503 | HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-??B signaling to protect breast cancer cells from complement attack. | FEBS Lett | 2012 Mar 23 | Cui W | doi: 10.1016/j.febslet.2012.01.039 |
| 21285250 | The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases. | Cancer Res | 2011 Mar 15 | Ranahan WP | doi: 10.1158/0008-5472.CAN-10-1995 |
| 17068343 | Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest. | J Biol Chem | 2006 Dec 22 | Sarfaraz S | - |
| 20956553 | Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs. | Mol Cell Biol | 2011 Jan | Madak-Erdogan Z | doi: 10.1128/MCB.00821-10 |
| 18539490 | Effects of small interfering RNAs targeting MAPK1 on gene expression profile in HeLa cells as revealed by microarray analysis. | Cell Biol Int | 2008 Sep | Huang C | doi: 10.1016/j.cellbi.2008.04.019 |
| 20889557 | High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. | Am J Pathol | 2010 Nov | Watson C | doi: 10.2353/ajpath.2010.100220 |
| 17550972 | CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway. | J Cell Sci | 2007 Jun 15 | Chen PS | - |
| 20203690 | Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest. | Cell Death Differ | 2010 Sep | Chan QK | doi: 10.1038/cdd.2010.20 |
| 21959954 | Overexpression of MUC1 enhances proangiogenic activity of non-small-cell lung cancer cells through activation of Akt and extracellular signal-regulated kinase pathways. | Lung | 2011 Dec | Yao M | doi: 10.1007/s00408-011-9327-y |
| 20335309 | SOCS-3 antagonises the proliferative and migratory effects of fibroblast growth factor-2 in prostate cancer by inhibition of p44/p42 MAPK signalling. | Endocr Relat Cancer | 2010 May 18 | Puhr M | doi: 10.1677/ERC-10-0007 |
| 17667937 | Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. | Oncogene | 2007 Sep 6 | Moniz S | - |
| 21548882 | Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment. | Biochem J | 2011 Aug 1 | Filomeni G | doi: 10.1042/BJ20110510. |
| 26503828 | Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways. | Oncol Rep | 2015 Dec | Min J | - |
| 26163656 | Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration. | Elife | 2015 Jul 11 | Logue JS | doi: 10.7554/eLife.08314. |
| 23338561 | Antitumor properties of salinomycin on cisplatin-resistant human ovarian cancer cells in vitro and in vivo: involvement of p38 MAPK activation. | Oncol Rep | 2013 Apr | Zhang B | doi: 10.3892/or.2013.2241 |
| 18256791 | Diallyl sulfide induces apoptosis in Colo 320 DM human colon cancer cells: involvement of caspase-3, NF-kappaB, and ERK-2. | Mol Cell Biochem | 2008 Apr | Sriram N | doi: 10.1007/s11010-008-9706-8 |
| 15882975 | Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation. | Biochem Biophys Res Commun | 2005 Jun 17 | Pai R | - |
| 16273204 | A mutation in the common docking domain of ERK2 in a human cancer cell line, which was associated with its constitutive phosphorylation. | Int J Oncol | 2005 Dec | Arvind R | - |
| 25167778 | Differential subcellular and extracellular localisations of proteins required for insulin-like growth factor- and extracellular matrix-induced signalling events in breast cancer progression. | BMC Cancer | 2014 Aug 29 | Plant HC | doi: 10.1186/1471-2407-14-627. |
| 22406505 | Muscarinic cholinergic signaling in cervical cancer cells affects cell motility via ERK1/2 signaling. | Life Sci | 2012 Nov 27 | Parnell EA | doi: 10.1016/j.lfs.2012.02.020 |
| 22658382 | pERK activation in esophageal carcinomas: clinicopathological associations. | Pathol Res Pract | 2012 Jul 15 | Tasioudi KE | doi: 10.1016/j.prp.2012.05.009 |
| 20464500 | The expression and activation of ERK/MAPK pathway in human esophageal cancer cell line EC9706. | Mol Biol Rep | 2011 Feb | Zheng ST | doi: 10.1007/s11033-010-0178-z |
| 17991320 | [The role of ERK1/2 in leptin promoting the proliferation of human endometrial cancer cell line Ishikawa]. | Ai Zheng | 2007 Nov | Gong C | - |
| 16705745 | connection regulates the proliferation of breast cancer cells. | Mol Carcinog | 2006 Oct | Vellon L | - |
| 25122124 | Snail promotes epithelial mesenchymal transition in breast cancer cells in part via activation of nuclear ERK2. | PLoS One | 2014 Aug 14 | Smith BN | doi: 10.1371/journal.pone.0104987 |
| 25230705 | DUSP28 contributes to human hepatocellular carcinoma via regulation of the p38 MAPK signaling. | Int J Oncol | 2014 Dec | Wang D | doi: 10.3892/ijo.2014.2653 |
| 21076047 | Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate cancer cells. | Mol Cancer Res | 2011 Jan | Chetram MA | doi: 10.1158/1541-7786.MCR-10-0235 |
| 18426913 | Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. | Mol Cell Biol | 2008 Jun | Miller AV | doi: 10.1128/MCB.01465-07 |
| 25605020 | Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression. | Oncotarget | 2015 Feb 20 | Yu S | - |
| 23306155 | Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9. | Am J Pathol | 2013 Mar | Dong QZ | doi: 10.1016/j.ajpath.2012.11.019 |
| 26767647 | Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma. | Mol Biol Rep | 2016 Feb | Mehdizadeh A | doi: 10.1007/s11033-016-3943-9 |
| 20837468 | Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. | J Biol Chem | 2010 Nov 12 | Long JS | doi: 10.1074/jbc.M110.117945 |
| 23806693 | CDK-associated Cullin 1 promotes cell proliferation with activation of ERK1/2 in human lung cancer A549 cells. | Biochem Biophys Res Commun | 2013 Jul 19 | Chen TJ | doi: 10.1016/j.bbrc.2013.06.048 |
| 15078890 | Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK. | J Biol Chem | 2004 Jun 18 | Nishihara H | - |
| 15173068 | Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells. | Clin Cancer Res | 2004 Jun 1 | Yang Z | - |
| 26346167 | MiR-378 suppresses prostate cancer cell growth through downregulation of MAPK1 in vitro and in vivo. | Tumour Biol | 2016 Feb | Chen QG | doi: 10.1007/s13277-015-3996-8 |
| 24691442 | Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. | J Clin Invest | 2014 May | Li C | - |
| 16395709 | p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis. | Int J Cancer | 2006 Jun 15 | Coltella N | - |
| 26182292 | P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway. | PLoS One | 2015 Jul 16 | Li WH | doi: 10.1371/journal.pone.0133165 |
| 25497010 | Restoration of IRF1-dependent anticancer effects by MEK inhibition in human cancer cells. | Cancer Lett | 2015 Feb 28 | AbuSara N | doi: 10.1016/j.canlet.2014.12.017 |
| 25150310 | Annexin A2 is implicated in multi-drug-resistance in gastric cancer through p38MAPK and AKT pathway. | Neoplasma | 2014 | Zhang ZD | doi: 10.4149/neo_2014_078. |
| 26823699 | Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mTOR/S6K and ERK1/2 signaling. | Int J Clin Exp Pathol | 2015 Nov 1 | Mu DW | - |
| 24342355 | pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner. | Mol Oncol | 2014 Mar | Mandal R | doi: 10.1016/j.molonc.2013.11.003 |
| 22344606 | Sunitinib enhances antitumor effects against chemotherapy-resistant bladder cancer through suppression of ERK1/2 phosphorylation. | Int J Oncol | 2012 May | Takeuchi A | doi: 10.3892/ijo.2012.1368 |
| 22117074 | Epidermal growth factor receptor (EGFR)-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT protein pathways is required for survival of human breast cancer cells. | J Biol Chem | 2012 Jan 27 | Nunes-Xavier CE | doi: 10.1074/jbc.M111.293928 |
| 19782465 | Lithocholic acid upregulates uPAR and cell invasiveness via MAPK and AP-1 signaling in colon cancer cells. | Cancer Lett | 2010 Apr 1 | Baek MK | doi: 10.1016/j.canlet.2009.08.030 |
| 19020743 | EGF stimulates uPAR expression and cell invasiveness through ERK, AP-1, and NF-kappaB signaling in human gastric carcinoma cells. | Oncol Rep | 2008 Dec | Baek MK | - |
| 17531530 | Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha. | Biochim Biophys Acta | 2007 Jul | Hao F | - |
| 24657659 | GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation. | Cancer Lett | 2014 Jun 28 | Zhang D | doi: 10.1016/j.canlet.2014.03.006 |
| 22584435 | High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients. | Oncologist | 2012 | Bartholomeusz C | doi: 10.1634/theoncologist.2011-0377 |
| 18710790 | Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. | Cancer Lett | 2008 Nov 8 | Zhou X | doi: 10.1016/j.canlet.2008.05.028 |
| 21808062 | The heme oxygenase-1 protein is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK pathway and mediates anti-apoptotic signal. | J Biol Chem | 2011 Sep 23 | Banerjee P | doi: 10.1074/jbc.M111.248401 |
| 18224451 | Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells. | Cell Biol Toxicol | 2008 Oct | Li Z | doi: 10.1007/s10565-008-9054-1 |
| 26781754 | Upregulation of microRNA27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2mediated ERK signaling. | Mol Med Rep | 2016 Mar | Jiang J | doi: 10.3892/mmr.2016.4779 |
| 11960991 | Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta. | J Biol Chem | 2002 Jun 21 | Keshamouni VG | - |
| 20359813 | Matrix metalloproteinase-9 is required for tubular network formation and migration of resistant breast cancer cells MCF-7 through PKC and ERK1/2 signalling pathways. | Cancer Lett | 2010 Sep 28 | Karroum A | doi: 10.1016/j.canlet.2010.03.007 |
| 15655348 | Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells. | Cell Cycle | 2005 Mar | Car??n RW | - |
| 20415541 | shRNA interference for extracellular signal-regulated kinase 2 can inhibit the growth of esophageal cancer cell line Eca109. | J Recept Signal Transduct Res | 2010 Jun | Huo Q | doi: 10.3109/10799891003786200. |
| 14997206 | ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours. | Br J Cancer | 2004 Mar 8 | Vicent S | - |
| 20811717 | P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910. | Int J Oncol | 2010 Oct | Li LH | - |
| 25675421 | ARHI suppresses pancreatic cancer by regulating MAPK/ERK 1/2 pathway. | Pancreas | 2015 Mar | Hu Y | doi: 10.1097/MPA.0000000000000274. |
| 20093341 | Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells. | Toxicol Sci | 2010 Apr | Han EH | doi: 10.1093/toxsci/kfq013 |
| 15037631 | p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor. | J Biol Chem | 2004 May 21 | Qi X | - |
| 25655003 | IL-33 Promotes Gastric Cancer Cell Invasion and Migration Via ST2-ERK1/2 Pathway. | Dig Dis Sci | 2015 May | Yu XX | doi: 10.1007/s10620-014-3463-1 |
| 22262799 | A novel p38-MAPK signaling axis modulates neutrophil biology in head and neck cancer. | J Leukoc Biol | 2012 Apr | Dumitru CA | doi: 10.1189/jlb.0411193 |
| 14620918 | Bisphosphonate induced growth inhibition of breast cancer cells is augmented by p38 inhibition. | Breast Cancer Res Treat | 2003 Oct | Merrell M | - |
| 23644655 | Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity. | Oncogene | 2014 Apr 17 | Cardoso AP | doi: 10.1038/onc.2013.154 |
| 21415216 | Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer. | Clin Cancer Res | 2011 Apr 15 | Takezawa K | doi: 10.1158/1078-0432.CCR-10-2798 |
| 26046675 | Resveratrol Enhances Etoposide-Induced Cytotoxicity through Down-Regulating ERK1/2 and AKT-Mediated X-ray Repair Cross-Complement Group 1 (XRCC1) Protein Expression in Human Non-Small-Cell Lung Cancer Cells. | Basic Clin Pharmacol Toxicol | 2015 Dec | Ko JC | doi: 10.1111/bcpt.12425 |
| 25091805 | A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-independent growth in oral cancer cells that is mediated by Rac1 and ERK. | J Biomed Sci | 2014 Aug 5 | Su YF | doi: 10.1186/s12929-014-0067-1. |
| 26617770 | MicroRNA-133b inhibits proliferation and invasion of ovarian cancer cells through Akt and Erk1/2 inactivation by targeting epidermal growth factor receptor. | Int J Clin Exp Pathol | 2015 Sep 1 | Liu X | - |
| 27665471 | The reduction of IL-6 gene expression, pAKT, pERK1/2, pSTAT3 signaling pathways and invasion activity by gallic acid in prostate cancer PC3 cells. | Biomed Pharmacother | 2016 Dec | Heidarian E | doi: 10.1016/j.biopha.2016.09.046 |
| 24929539 | Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activation of p38 MAPK/ NF??B signaling pathway in gastric cancer cells. | J Biomed Sci | 2014 Jun 14 | Hsieh YY | doi: 10.1186/1423-0127-21-59. |
| 23923067 | RAF1-MEK1-ERK/AKT axis may confer NSCLC cell lines resistance to erlotinib. | Int J Clin Exp Pathol | 2013 Jul 15 | Xu ZH | - |
| 19930715 | PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling. | Mol Cancer | 2009 Nov 24 | Peng L | doi: 10.1186/1476-4598-8-110. |
| 25953087 | Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer. | Mol Cell Proteomics | 2015 Jul | Young CD | doi: 10.1074/mcp.M115.049783 |
| 22751131 | Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions. | Oncogene | 2013 Apr 11 | Couts KL | doi: 10.1038/onc.2012.209 |
| 23569008 | ERK1/2 activity contributes to gemcitabine resistance in pancreatic cancer cells. | J Int Med Res | 2013 Apr | Zheng C | doi: 10.1177/0300060512474128 |
| 23424616 | Human chorionic gonadotropin β induces migration and invasion via activating ERK1/2 and MMP-2 in human prostate cancer DU145 cells. | PLoS One | 2013 | Li Z | doi: 10.1371/journal.pone.0054592 |
| 26267535 | ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development. | Cancer Cell | 2015 Aug 10 | Fang L | doi: 10.1016/j.ccell.2015.07.004. |
| 24164897 | Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells. | Mol Cell Biol | 2014 Jan | Zhang F | doi: 10.1128/MCB.00987-13 |
| 25647783 | ERK1/2 promoted proliferation and inhibited apoptosis of human cervical cancer cells and regulated the expression of c-Fos and c-Jun proteins. | Med Oncol | 2015 Mar | Bai L | doi: 10.1007/s12032-015-0490-5 |
| 19686845 | Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway. | Cell Signal | 2009 Dec | Krueger F | doi: 10.1016/j.cellsig.2009.07.020 |
| 26510428 | MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1. | J Med Genet | 2016 Jan | Kouhkan F | doi: 10.1136/jmedgenet-2015-103225 |
| 26879318 | Biphasic activation of extracellular signal-regulated kinase (ERK) 1/2 in epidermal growth factor (EGF)-stimulated SW480 colorectal cancer cells. | BMB Rep | 2016 Apr | Joo D | - |
| 19008312 | A positive feedback between activated extracellularly regulated kinase and cyclooxygenase/lipoxygenase maintains proliferation and migration of breast cancer cells. | Endocrinology | 2009 Apr | You J | doi: 10.1210/en.2008-0616 |
| 22564243 | Caveolin-1 interferes cell growth of lung cancer NCI-H446 cell through the interactions with phospho-ERK1/2, estrogen receptor and progestin receptor. | Biomed Pharmacother | 2012 Jun | Sun MZ | doi: 10.1016/j.biopha.2011.11.003 |
| 17341442 | Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells. | Cell Signal | 2007 Jul | Cao Z | - |
| 25398317 | An increase in integrin-linked kinase non-canonically confers NF-??B-mediated growth advantages to gastric cancer cells by activating ERK1/2. | Cell Commun Signal | 2014 Nov 15 | Tseng PC | doi: 10.1186/s12964-014-0069-3. |
| 19151763 | Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen receptor activation and increased HIF-1alpha levels contribute to emergence of an aggressive phenotype in prostate cancer. | Oncogene | 2009 Mar 5 | Khandrika L | doi: 10.1038/onc.2008.476 |
| 19032445 | Proliferative effects of gamma-aminobutyric acid on the gastric cancer cell line are associated with extracellular signal-regulated kinase 1/2 activation. | J Gastroenterol Hepatol | 2009 Apr | Maemura K | doi: 10.1111/j.1440-1746.2008.05687.x |
| 25085753 | ERK1/2 is related to oestrogen receptor and predicts outcome in hormone-treated breast cancer. | Breast Cancer Res Treat | 2014 Aug | Jerjees DA | doi: 10.1007/s10549-014-3066-8 |
| 23538858 | ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity. | Mol Cancer Res | 2013 Jul | Jin F | doi: 10.1158/1541-7786.MCR-12-0618 |
| 17469127 | Cholesterol level of lipid raft microdomains regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK signal transduction. | Prostate | 2007 Jul 1 | Oh HY | - |
| 25738359 | Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells. | Oncotarget | 2015 Feb 28 | You B | - |
| 23620784 | Propagation of human prostate cancer stem-like cells occurs through EGFR-mediated ERK activation. | PLoS One | 2013 Apr 19 | Rybak AP | doi: 10.1371/journal.pone.0061716 |
| 16611738 | Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway. | Am J Physiol Cell Physiol | 2006 Sep | Tan EY | - |
| 18055485 | Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancers. | J Mol Endocrinol | 2007 Dec | Nakamura M | - |
| 22076613 | Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell. | Int J Colorectal Dis | 2012 Apr | Jia ZC | doi: 10.1007/s00384-011-1351-0 |
| 12408764 | Expression of extracellular signal-regulated kinase and its relationship with clinicopathological characteristics of breast cancer. | Zhonghua Zhong Liu Za Zhi | 2002 Jul | Wang Z | - |
| 26612919 | Sulforaphene promotes Bax/Bcl2, MAPK-dependent human gastric cancer AGS cells apoptosis and inhibits migration via EGFR, p-ERK1/2 down-regulation. | Gen Physiol Biophys | 2016 Jan | Mondal A | doi: 10.4149/gpb_2015033 |
| 23360766 | Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines. | Biochim Biophys Acta | 2013 Jul | Rose HM | doi: 10.1016/j.bbapap.2013.01.023 |
| 19152186 | PRL-3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up-regulating the levels and activities of Rho-A/C in lung cancer. | Pathology | 2009 Feb | Ming J | doi: 10.1080/00313020802579268. |
| 25128071 | The p38 MAPK-regulated PKD1/CREB/Bcl-2 pathway contributes to selenite-induced colorectal cancer cell apoptosis in vitro and in vivo. | Cancer Lett | 2014 Nov 1 | Hui K | doi: 10.1016/j.canlet.2014.08.009 |
| 18311544 | High intracellular Zn2+ ions modulate the VHR, ZAP-70 and ERK activities of LNCaP prostate cancer cells. | Cell Mol Biol Lett | 2008 | Wong PF | doi: 10.2478/s11658-008-0009-6 |
| 22927430 | CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms. | J Biol Chem | 2012 Oct 19 | Fang WB | doi: 10.1074/jbc.M112.365999 |
| 22865467 | EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. | Mol Cell Biochem | 2012 Nov | Park YS | doi: 10.1007/s11010-012-1410-z |
| 16209712 | Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation. | Mol Cancer | 2005 Oct 6 | Sawai H | - |
| 21444628 | Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells. | J Pharmacol Exp Ther | 2011 Jul | Ko JC | doi: 10.1124/jpet.111.179663 |
| 27395339 | Cold-inducible RNA-binding protein promotes epithelial-mesenchymal transition by activating ERK and p38 pathways. | Biochem Biophys Res Commun | 2016 Sep 2 | Lee HN | doi: 10.1016/j.bbrc.2016.07.028 |
| 28393232 | MicroRNA-329-3p targets MAPK1 to suppress cell proliferation, migration and invasion in cervical cancer. | Oncol Rep | 2017 May | Li W | doi: 10.3892/or.2017.5555 |
| 28178265 | Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells. | PLoS Comput Biol | 2017 Feb 8 | Bazzazi H | doi: 10.1371/journal.pcbi.1005332 |
| 27791265 | GLUL Promotes Cell Proliferation in Breast Cancer. | J Cell Biochem | 2017 Aug | Wang Y | doi: 10.1002/jcb.25775 |
| 28844715 | Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells. | Cancer Lett | 2017 Nov 1 | Datta A | doi: 10.1016/j.canlet.2017.08.020 |
| 28933561 | CKAP2 Promotes Ovarian Cancer Proliferation and Tumorigenesis Through the FAK-ERK Pathway. | DNA Cell Biol | 2017 Nov | Zhang M | doi: 10.1089/dna.2017.3876 |
| 28876465 | Procyanidin B2 3,3??-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK. | Mol Carcinog | 2018 Jan | Kumar R | doi: 10.1002/mc.22731 |
| 26872057 | The molecular and clinical verification of therapeutic resistance via the p38 MAPK-Hsp27 axis in lung cancer. | Oncotarget | 2016 Mar 22 | Liu CL | doi: 10.18632/oncotarget.7306. |
| 28992617 | Iodine Promotes Tumorigenesis of Thyroid Cancer by Suppressing Mir-422a and Up-Regulating MAPK1. | Cell Physiol Biochem | 2017 | Wang J | doi: 10.1159/000481844 |
| 28230290 | A3 Adenosine Receptor Agonist Inhibited Survival of Breast Cancer Stem Cells via GLI-1 and ERK1/2 Pathway. | J Cell Biochem | 2017 Sep | Jafari SM | doi: 10.1002/jcb.25945 |
| 27391062 | Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922. | Oncotarget | 2016 Aug 2 | Wang CY | doi: 10.18632/oncotarget.10414. |
| 28396364 | Novel Indole-based Tambjamine-Analogues Induce Apoptotic Lung Cancer Cell Death through p38 Mitogen-Activated Protein Kinase Activation. | Mol Cancer Ther | 2017 Jul | Manuel-Manresa P | doi: 10.1158/1535-7163.MCT-16-0752 |
| 28285962 | The ERK/MAPK pathway is overexpressed and activated in gallbladder cancer. | Pathol Res Pract | 2017 May | Buchegger K | doi: 10.1016/j.prp.2017.01.025 |
| 28713983 | MalforminA1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through stimulation of the p38 signaling pathway. | Int J Oncol | 2017 Sep | Park SY | doi: 10.3892/ijo.2017.4070 |
| 27624978 | Integrin α6/Akt/Erk signaling is essential for human breast cancer resistance to radiotherapy. | Sci Rep | 2016 Sep 14 | Hu T | doi: 10.1038/srep33376. |
| 27564099 | Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2. | Oncotarget | 2016 Sep 27 | Park BH | doi: 10.18632/oncotarget.11563. |
| 28287251 | Cisplatin induced apoptosis of ovarian cancer A2780s cells by activation of ERK/p53/PUMA signals. | Histol Histopathol | 2018 Jan | Song H | doi: 10.14670/HH-11-889 |
| 28990044 | MicroRNA320 targets mitogenactivated protein kinase 1 to inhibit cell proliferation and invasion in epithelial ovarian cancer. | Mol Med Rep | 2017 Dec | Xu Y | doi: 10.3892/mmr.2017.7664 |
| 28492138 | Long Noncoding RNA SChLAP1 Accelerates the Proliferation and Metastasis of Prostate Cancer via Targeting miR-198 and Promoting the MAPK1 Pathway. | Oncol Res | 2018 Jan 19 | Li Y | doi: 10.3727/096504017X14944585873631 |
| 29335299 | HOTAIR contributes to cell proliferation and metastasis of cervical cancer via targetting miR-23b/MAPK1 axis. | Biosci Rep | 2018 Feb 8 | Li Q | doi: 10.1042/BSR20171563 |
| 29286172 | MicroRNA-454 inhibits the malignant biological behaviours of gastric cancer cells by directly targeting mitogen-activated protein kinase 1. | Oncol Rep | 2018 Mar | Wang X | doi: 10.3892/or.2017.6171 |
| 27780852 | High-Throughput Screening Identifies miR-451 as a Pleiotropic Modulator That Suppresses Gastric Cancer Metastasis. | SLAS Technol | 2017 Apr | You W | doi: 10.1177/2211068216675858 |
| 30249660 | Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis. | Proc Natl Acad Sci U S A | 2018 Oct 9 | Xiao GY | doi: 10.1073/pnas.1810209115 |
| 29321092 | MicroRNA-212 Targets Mitogen-Activated Protein Kinase 1 to Inhibit Proliferation and Invasion of Prostate Cancer Cells. | Oncol Res | 2018 Aug 23 | Hu B | doi: 10.3727/096504018X15154112497142 |
| 29575240 | Role of p38 MAPK in disease relapse and therapeutic resistance by maintenance of cancer stem cells in head and neck squamous cell carcinoma. | J Oral Pathol Med | 2018 May | Roy S | doi: 10.1111/jop.12707 |
| 30139661 | AKR1C3, a crucial androgenic enzyme in prostate cancer, promotes epithelial-mesenchymal transition and metastasis through activating ERK signaling. | Urol Oncol | 2018 Oct | Wang B | doi: 10.1016/j.urolonc.2018.07.005 |
| 30126634 | A novel long noncoding RNA OECC promotes colorectal cancer development and is negatively regulated by miR-143-3p. | Biochem Biophys Res Commun | 2018 Sep 18 | Huang F | doi: 10.1016/j.bbrc.2018.08.075 |
| 30157211 | The A2B adenosine receptor in MDA-MB-231 breast cancer cells diminishes ERK1/2 phosphorylation by activation of MAPK-phosphatase-1. | PLoS One | 2018 Aug 29 | Kouss??mou M | doi: 10.1371/journal.pone.0202914 |
| 29084209 | MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells. | Oncogene | 2018 Feb 22 | Schroyer AL | doi: 10.1038/onc.2017.396 |
| 29717031 | Piperine functions as a tumor suppressor for human ovarian tumor growth via activation of JNK/p38 MAPK-mediated intrinsic apoptotic pathway. | Biosci Rep | 2018 May 31 | Si L | doi: 10.1042/BSR20180503 |
| 28910941 | [Effects of Src on cervical cancer cells proliferation and apoptosis through ERK signal transduction pathway]. | Zhonghua Liu Xing Bing Xue Za Zhi | 2017 Sep 10 | Song ZC | doi: 10.3760/cma.j.issn.0254-6450.2017.09.021. |
