EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23022728	Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness.	Nat Struct Mol Biol	2012 Nov	Dardenne E	doi: 10.1038/nsmb.2390
17699760	Involvement of RNA helicases p68 and p72 in colon cancer.	Cancer Res	2007 Aug 15	Shin S	-
26569340	DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer.	Cell Signal	2016 Feb	Alqahtani H	doi: 10.1016/j.cellsig.2015.11.004
28259822	DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of β-catenin.	Cancer Lett	2017 Aug 1	Li K	doi: 10.1016/j.canlet.2017.02.029

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr22	38486356	Missense_Mutation	novel	G590E	0.25
BLCA	chr22	38494933	Missense_Mutation	NA	D332H	0.33	DEAD
BLCA	chr22	38506214	Silent	novel	P8P	1
BLCA	chr22	38486110	Missense_Mutation	rs749066420	S672L	0.55
BLCA	chr22	38488223	Intron	novel		0.07
BLCA	chr22	38488224	Intron	novel		0.07
BLCA	chr22	38494645	Missense_Mutation	novel	S400T	0.12
BLCA	chr22	38486378	Missense_Mutation	novel	E583K	0.32
BLCA	chr22	38494660	Missense_Mutation	novel	D395G	0.08
BLCA	chr22	38486075	Missense_Mutation	NA	R684G	0.22
BRCA	chr22	38506316	5'Flank	novel		0.82
BRCA	chr22	38488198	Intron	novel		0.15
BRCA	chr22	38495883	Missense_Mutation	novel	D265Y	0.05	DEAD
BRCA	chr22	38485957	Missense_Mutation	novel	P723L	0.06
BRCA	chr22	38485695	3'Flank	novel		0.14
BRCA	chr22	38486168	Missense_Mutation	rs762058898	Q653E	0.35
BRCA	chr22	38506322	5'Flank	novel		0.13
BRCA	chr22	38495861	Missense_Mutation	NA	R272T	0.36	DEAD
BRCA	chr22	38485755	3'Flank	novel		0.63
BRCA	chr22	38492076	Missense_Mutation	novel	D476G	0.19
BRCA	chr22	38494084	Missense_Mutation	NA	T421K	0.21
CESC	chr22	38494730	Missense_Mutation	rs746498158	R372C	0.27
CESC	chr22	38485518	3'Flank	novel		0.83
CESC	chr22	38499458	Silent	NA	V160V	0.44
CESC	chr22	38485695	3'Flank	novel		0.15
CESC	chr22	38506076	Silent	novel	V54V	0.53
CESC	chr22	38486074	Missense_Mutation	NA	R684Q	0.5
CESC	chr22	38494030	Missense_Mutation	novel	R439H	0.37
CESC	chr22	38507637	5'Flank	novel		0.45
CHOL	chr22	38485695	3'Flank	novel		0.13
COAD	chr22	38488011	Missense_Mutation	NA	A518T	0.1
COAD	chr22	38485992	Silent	NA	G711G	0.43
COAD	chr22	38488164	Intron	rs1065365		0.45
COAD	chr22	38506199	Silent	novel	L13L	0.11
COAD	chr22	38494742	Missense_Mutation	novel	E368K	0.32
COAD	chr22	38506088	Silent	novel	P50P	0.36
COAD	chr22	38499400	Nonsense_Mutation	NA	Q180*	0.44
COAD	chr22	38494045	Missense_Mutation	NA	L434P	0.27
COAD	chr22	38486278	Missense_Mutation	novel	G616D	0.18
COAD	chr22	38486380	Missense_Mutation	NA	D582V	0.19
COAD	chr22	38501152	Missense_Mutation	novel	P139L	0.13
COAD	chr22	38493740	Missense_Mutation	novel	S453G	0.04
COAD	chr22	38501206	Frame_Shift_Del	rs759023106	*K121Sfs4**	0.59
COAD	chr22	38486163	Missense_Mutation	NA	E654D	0.17
COAD	chr22	38498085	Splice_Region	rs201507084	I246I	0.17
ESCA	chr22	38485700	3'Flank	novel		0.13
ESCA	chr22	38485695	3'Flank	novel		0.6
ESCA	chr22	38498456	Missense_Mutation	novel	S219C	0.44	DEAD
GBM	chr22	38494063	Frame_Shift_Del	novel	*K428Efs4**	0.13
GBM	chr22	38486421	Silent	NA	R568R	0.18
GBM	chr22	38498147	Missense_Mutation	novel	L226F	0.16	DEAD
GBM	chr22	38498457	Missense_Mutation	novel	S219P	0.23	DEAD
GBM	chr22	38499477	Missense_Mutation	rs753839666	R154Q	0.27
GBM	chr22	38487959	Missense_Mutation	NA	K535R	0.11
GBM	chr22	38485919	3'UTR	novel		0.23
GBM	chr22	38494674	Silent	novel	I390I	0.09
GBM	chr22	38495042	Silent	novel	V295V	0.05
GBM	chr22	38501247	Silent	rs776275831	P107P	0.38
KIRC	chr22	38493712	Missense_Mutation	NA	N462S	0.24
KIRC	chr22	38488227	Intron	novel		0.13
KIRP	chr22	38501258	Missense_Mutation	novel	G104C	0.27
KIRP	chr22	38488289	Intron	novel		0.58
KIRP	chr22	38486027	Missense_Mutation	novel	P700T	0.11
LAML	chr22	38498084	Splice_Site	NA	X246_splice	0.32
LGG	chr22	38494942	Missense_Mutation	NA	R329G	0.36	DEAD
LIHC	chr22	38494721	Missense_Mutation	novel	T375S	0.08
LIHC	chr22	38486311	Missense_Mutation	NA	R605P	0.05
LIHC	chr22	38494027	Missense_Mutation	novel	R440I	0.34
LUAD	chr22	38488175	Intron	rs542203796		0.26
LUAD	chr22	38486073	Frame_Shift_Del	novel	*S685Lfs8**	0.07
LUAD	chr22	38488140	Intron	novel		0.73
LUAD	chr22	38495932	Silent	novel	L248L	0.08
LUAD	chr22	38494691	Missense_Mutation	NA	S385C	0.27
LUAD	chr22	38495880	Missense_Mutation	NA	D266Y	0.13	DEAD
LUAD	chr22	38487884	Missense_Mutation	novel	G560D	0.2
LUAD	chr22	38494749	Missense_Mutation	novel	Q365H	0.24	DEAD
LUSC	chr22	38486075	Missense_Mutation	NA	R684G	0.2
LUSC	chr22	38486368	Missense_Mutation	rs748322707	R586Q	0.1
LUSC	chr22	38498554	Silent	NA	L186L	0.09
LUSC	chr22	38499446	Silent	novel	D164D	0.12
MESO	chr22	38486357	Missense_Mutation	novel	G590R	0.36
OV	chr22	38494697	Nonsense_Mutation	novel	E383*	0.05
OV	chr22	38499455	Missense_Mutation	NA	R161S	0.16
OV	chr22	38486360	Nonsense_Mutation	novel	R589*	0.39
OV	chr22	38485942	Missense_Mutation	novel	R728L	0.04
OV	chr22	38488194	Intron	novel		0.05
OV	chr22	38493732	Silent	novel	P455P	0.04
OV	chr22	38488324	Intron	novel		0.21
OV	chr22	38485977	Silent	NA	Q716Q	0.94
OV	chr22	38488220	Intron	novel		0.08
OV	chr22	38487952	Silent	NA	L537L	0.19
OV	chr22	38494661	Missense_Mutation	novel	D395Y	0.06
PRAD	chr22	38487941	Missense_Mutation	rs546476409	N541S	0.42
SARC	chr22	38485695	3'Flank	novel		0.12
SARC	chr22	38488261	Intron	rs755482845		0.64
SARC	chr22	38485700	3'Flank	novel		0.41
SARC	chr22	38485695	3'Flank	novel		0.15
SKCM	chr22	38493748	Missense_Mutation	NA	G450E	0.34
SKCM	chr22	38506166	Silent	NA	V24V	0.4
SKCM	chr22	38495811	Nonsense_Mutation	NA	R289*	0.47	DEAD
SKCM	chr22	38488052	Missense_Mutation	NA	H504R	0.38
SKCM	chr22	38488032	Missense_Mutation	rs747579584	R511C	0.29
SKCM	chr22	38488110	Nonsense_Mutation	NA	E485*	0.2
SKCM	chr22	38498452	Silent	rs148438451	G220G	0.11
SKCM	chr22	38485961	Missense_Mutation	NA	P722S	0.43
SKCM	chr22	38488052	Missense_Mutation	NA	H504R	0.4
SKCM	chr22	38495905	Silent	NA	A257A	0.18
SKCM	chr22	38495812	Missense_Mutation	NA	I288M	0.22	DEAD
SKCM	chr22	38494734	Silent	NA	F370F	0.13
SKCM	chr22	38501250	Silent	novel	P106P	0.63
SKCM	chr22	38486380	Missense_Mutation	NA	D582G	0.18
SKCM	chr22	38498504	Missense_Mutation	rs549944631	P203L	0.4	DEAD
SKCM	chr22	38488052	Missense_Mutation	NA	H504R	0.26
SKCM	chr22	38488052	Missense_Mutation	NA	H504R	0.18
STAD	chr22	38499450	Frame_Shift_Del	NA	*G163Efs20**	0.37
STAD	chr22	38493727	Missense_Mutation	NA	R457T	0.09
STAD	chr22	38486015	Missense_Mutation	novel	T704A	0.45
STAD	chr22	38486428	Missense_Mutation	rs749692045	R566H	0.44
STAD	chr22	38501206	Frame_Shift_Del	rs759023106	*K121Sfs4**	0.42
STAD	chr22	38486434	Missense_Mutation	rs774718067	R564H	0.21
STAD	chr22	38486007	Missense_Mutation	NA	M706I	0.33
STAD	chr22	38499430	Missense_Mutation	NA	V170M	0.05
STAD	chr22	38501206	Frame_Shift_Del	rs759023106	*K121Sfs4**	0.37
STAD	chr22	38501205	Frame_Shift_Ins	novel	*W122Sfs4**	0.28
STAD	chr22	38495885	Missense_Mutation	novel	A264V	0.2	DEAD
STAD	chr22	38486067	Silent	novel	G686G	0.48
STAD	chr22	38488262	Intron	novel		0.58
STAD	chr22	38501206	Frame_Shift_Del	rs759023106	*K121Sfs4**	0.47
STAD	chr22	38501206	Frame_Shift_Del	rs759023106	*K121Sfs4**	0.37
STAD	chr22	38488242	Intron	novel		0.24
STAD	chr22	38494729	Missense_Mutation	NA	R372H	0.27
STAD	chr22	38501206	Frame_Shift_Del	rs759023106	*K121Sfs4**	0.44
TGCT	chr22	38499494	Missense_Mutation	novel	E148D	0.18
THYM	chr22	38484195	3'Flank	novel		0.09
THYM	chr22	38485695	3'Flank	novel		0.18
THYM	chr22	38485695	3'Flank	novel		0.14
UCEC	chr22	38485695	3'Flank	novel		0.14
UCEC	chr22	38498468	Missense_Mutation	novel	A215V	0.07	DEAD
UCEC	chr22	38494973	Silent	novel	R318R	0.39
UCEC	chr22	38495818	Silent	rs772157868	P286P	0.6
UCEC	chr22	38495844	Missense_Mutation	novel	I278F	0.44	DEAD
UCEC	chr22	38483943	3'Flank	novel		0.3
UCEC	chr22	38506224	Missense_Mutation	novel	F5C	0.14
UCEC	chr22	38495828	Missense_Mutation	novel	P283H	0.36	DEAD
UCEC	chr22	38506278	5'UTR	rs753475889		0.52
UCEC	chr22	38499457	Missense_Mutation	novel	R161G	0.19
UCEC	chr22	38501166	Missense_Mutation	novel	F134L	0.23
UCEC	chr22	38488059	Missense_Mutation	novel	Y502H	0.08
UCEC	chr22	38485957	Missense_Mutation	NA	P723H	0.29
UCEC	chr22	38487993	Missense_Mutation	NA	P524S	0.53
UCEC	chr22	38488179	Intron	novel		0.09
UCEC	chr22	38484081	3'Flank	novel		0.45
UCEC	chr22	38507627	5'Flank	novel		0.18
UCEC	chr22	38488210	Intron	novel		0.11
UCEC	chr22	38485959	Silent	NA	P722P	0.4
UCEC	chr22	38501206	Frame_Shift_Del	rs759023106	*K121Sfs4**	0.45
UCEC	chr22	38501206	Frame_Shift_Del	rs759023106	*K121Sfs4**	0.53
UCEC	chr22	38493720	Missense_Mutation	novel	W459C	0.24
UCEC	chr22	38484081	3'Flank	novel		0.41
UCEC	chr22	38488327	Intron	novel		0.31
UCEC	chr22	38495878	Missense_Mutation	novel	D266E	0.48	DEAD
UCEC	chr22	38498504	Missense_Mutation	rs549944631	P203L	0.41	DEAD
UCEC	chr22	38486360	Nonsense_Mutation	novel	R589*	0.29
UCEC	chr22	38499450	Frame_Shift_Del	NA	*G163Efs20**	0.41
UCEC	chr22	38484077	3'Flank	novel		0.08
UCEC	chr22	38501222	Missense_Mutation	novel	R116C	0.41
UCEC	chr22	38506062	Missense_Mutation	novel	P59Q	0.52
UCEC	chr22	38484155	3'Flank	novel		0.36
UCEC	chr22	38485840	3'Flank	rs765220952		0.81
UCEC	chr22	38501244	Missense_Mutation	NA	K108N	0.43
UCEC	chr22	38495831	Missense_Mutation	novel	A282V	0.41	DEAD
UCEC	chr22	38499443	Silent	novel	V165V	0.13
UCEC	chr22	38484222	3'Flank	novel		0.3
UCEC	chr22	38501206	Frame_Shift_Del	rs759023106	*K121Sfs4**	0.41
UCEC	chr22	38494733	Missense_Mutation	novel	L371I	0.37
UCEC	chr22	38506340	5'Flank	rs565910471		0.42
UCEC	chr22	38484073	3'Flank	novel		0.22
UCEC	chr22	38485873	3'Flank	novel		0.36
UCEC	chr22	38485974	Silent	rs144402360	Y717Y	0.14
UCEC	chr22	38501169	Frame_Shift_Ins	novel	*N133Kfs16**	0.43
UCEC	chr22	38499450	Frame_Shift_Del	NA	*G163Efs20**	0.37
UCEC	chr22	38499450	Frame_Shift_Del	NA	*G163Efs20**	0.42
UCEC	chr22	38488261	Intron	rs755482845		0.46
UCEC	chr22	38485699	3'Flank	NA		0.33
UCEC	chr22	38494904	Missense_Mutation	NA	K341N	0.3	DEAD
UCEC	chr22	38501206	Frame_Shift_Del	rs759023106	*K121Sfs4**	0.37
UCEC	chr22	38486149	Missense_Mutation	novel	T659I	0.17
UCEC	chr22	38506210	Missense_Mutation	novel	L10F	0.21
UCEC	chr22	38486074	Missense_Mutation	NA	R684Q	0.34
UCEC	chr22	38484161	3'Flank	novel		0.42
UCEC	chr22	38499450	Frame_Shift_Del	NA	*G163Efs20**	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PCPG	DEL	0.3272	0.044123
THCA	DEL	0.1563	0.046486
THYM	DEL	0.0813	0.063154

Survival Analysis

Cancer	P-value	Q-value
ACC	0.013	Kaplan-Meier Survival Analysis
UCS	0.04	Kaplan-Meier Survival Analysis
HNSC	0.044	Kaplan-Meier Survival Analysis
SKCM	0.016	Kaplan-Meier Survival Analysis
ESCA	0.037	Kaplan-Meier Survival Analysis
BLCA	0.0026	Kaplan-Meier Survival Analysis
CESC	0.027	Kaplan-Meier Survival Analysis
READ	0.00055	Kaplan-Meier Survival Analysis
GBM	0.036	Kaplan-Meier Survival Analysis
LIHC	0.018	Kaplan-Meier Survival Analysis
LGG	0.02	Kaplan-Meier Survival Analysis
LUAD	0.036	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100201 (Gene tree)
Gene ID: 10521
Gene Symbol: DDX17
Alias: P72
Full Name: DEAD-box helicase 17
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 24,223 bases
Position: chr22:38,483,438-38,507,660
Accession: 2740
RBP type: canonical RBP
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000491244	DEAD	PF00270.29	4.8e-49	1	1
ENSP00000385536	DEAD	PF00270.29	4.8e-49	1	1
ENSP00000491776	DEAD	PF00270.29	4.8e-49	1	1
ENSP00000380033	DEAD	PF00270.29	4.8e-49	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30131116	DDX17 Specifically, and Independently of DDX5, Controls Use of the HIV A4/5 Splice Acceptor Cluster and Is Essential for Efficient Replication of HIV.	J Mol Biol	2018 Sep 14	Sithole N	doi: 10.1016/j.jmb.2018.06.052
8871553	p72: a human nuclear DEAD box protein highly related to p68.	Nucleic Acids Res	1996 Oct 1	Lamm GM	-
11250900	A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA.	EMBO J	2001 Mar 15	Watanabe M	-
21846828	Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.	MBio	2011 Aug 16	Bortz E	doi: 10.1128/mBio.00151-11
24926617	p53-directed translational control can shape and expand the universe of p53 target genes.	Cell Death Differ	2014 Oct	Zaccara S	doi: 10.1038/cdd.2014.79
27478153	The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells.	Biochim Biophys Acta	2016 Oct	Connerty P	doi: 10.1016/j.bbagrm.2016.07.013
16935882	DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.	Nucleic Acids Res	2006	Fuller-Pace FV	-
17226766	Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF.	J Cell Biochem	2007 Aug 1	Shin S	-
23022728	Splicing switch of an epigenetic regulator by RNA helicases promotes tumor-cell invasiveness.	Nat Struct Mol Biol	2012 Nov	Dardenne E	doi: 10.1038/nsmb.2390
17011493	The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.	Dev Cell	2006 Oct	Caretti G	-
31321265	Data describing the effects of depletion of M yoparr, myogenin, Ddx17, and hnRNPK in differentiating C2C12 cells.	Data Brief	2019 Jun 24	Hitachi K	doi: 10.1016/j.dib.2019.104172

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000467279	DDX17-206	712	-	-	- (aa)	-	-
ENST00000475004	DDX17-207	443	-	ENSP00000489029	56 (aa)	-	A0A0U1RQJ0
ENST00000431312	DDX17-204	1853	-	-	- (aa)	-	-
ENST00000640332	DDX17-211	2190	-	ENSP00000491244	729 (aa)	-	Q92841
ENST00000432525	DDX17-205	1354	-	-	- (aa)	-	-
ENST00000477112	DDX17-208	654	-	-	- (aa)	-	-
ENST00000216019	DDX17-201	6441	-	-	- (aa)	-	-
ENST00000479734	DDX17-209	441	-	-	- (aa)	-	-
ENST00000396821	DDX17-202	4791	-	ENSP00000380033	731 (aa)	-	UPI0001AE634C
ENST00000403230	DDX17-203	2322	-	ENSP00000385536	729 (aa)	-	A0A1X7SBZ2
ENST00000640668	DDX17-212	2196	-	ENSP00000491776	731 (aa)	-	A0A1W2PQ51
ENST00000497196	DDX17-210	856	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100201's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100201	Child Development Disorders, Pervasive	3.1330000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100201	rs763121	22	38483935	G	Menopause (age at onset)	26414677	[0.12-0.2] years decrease	0.16	EFO_0004704
ENSG00000100201	rs1837988	22	38505089	?	Age at menopause	30595370			EFO_0004704

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100201's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000100201	DDX17	52	30.909	ENSG00000125485	DDX31	61	30.110
ENSG00000100201	DDX17	73	51.220	ENSG00000213782	DDX47	71	41.194
ENSG00000100201	DDX17	60	43.333	ENSG00000184735	DDX53	70	43.596
ENSG00000100201	DDX17	63	57.143	ENSG00000080007	DDX43	68	42.637
ENSG00000100201	DDX17	71	90.000	ENSG00000108654	DDX5	100	89.759
ENSG00000100201	DDX17	50	32.337	ENSG00000123064	DDX54	99	35.577
ENSG00000100201	DDX17	50	30.053	ENSG00000157349	DDX19B	96	30.053
ENSG00000100201	DDX17	68	52.632	ENSG00000141543	EIF4A3	82	35.277
ENSG00000100201	DDX17	50	33.784	ENSG00000124228	DDX27	88	31.429
ENSG00000100201	DDX17	53	39.568	ENSG00000174243	DDX23	55	40.000
ENSG00000100201	DDX17	50	34.218	ENSG00000165732	DDX21	51	33.952
ENSG00000100201	DDX17	63	65.714	ENSG00000215301	DDX3X	98	41.260
ENSG00000100201	DDX17	57	34.450	ENSG00000118197	DDX59	98	32.127
ENSG00000100201	DDX17	75	45.238	ENSG00000178105	DDX10	56	32.987
ENSG00000100201	DDX17	77	53.488	ENSG00000183258	DDX41	65	39.952
ENSG00000100201	DDX17	71	47.500	ENSG00000198231	DDX42	61	43.880
ENSG00000100201	DDX17	63	51.429	ENSG00000156976	EIF4A2	90	33.832
ENSG00000100201	DDX17	55	30.340	ENSG00000278053	DDX52	67	30.216
ENSG00000100201	DDX17	63	51.429	ENSG00000161960	EIF4A1	97	34.188
ENSG00000100201	DDX17	71	57.500	ENSG00000067048	DDX3Y	71	39.072
ENSG00000100201	DDX17	73	48.780	ENSG00000107625	DDX50	50	34.417
ENSG00000100201	DDX17	50	32.454	ENSG00000109832	DDX25	93	35.000
ENSG00000100201	DDX17	52	30.971	ENSG00000110367	DDX6	77	30.971
ENSG00000100201	DDX17	63	60.000	ENSG00000152670	DDX4	68	39.798

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100201	DDX17	71	97.500	ENSAPOG00000017303	si:dkey-156n14.5	93	74.641	Acanthochromis_polyacanthus
ENSG00000100201	DDX17	100	99.453	ENSAMEG00000010601	DDX17	100	99.453	Ailuropoda_melanoleuca
ENSG00000100201	DDX17	71	97.500	ENSAOCG00000004874	si:dkey-156n14.5	93	74.290	Amphiprion_ocellaris
ENSG00000100201	DDX17	71	97.500	ENSAPEG00000018317	si:dkey-156n14.5	94	74.062	Amphiprion_percula
ENSG00000100201	DDX17	71	97.500	ENSATEG00000021733	si:dkey-156n14.5	95	73.892	Anabas_testudineus
ENSG00000100201	DDX17	71	100.000	ENSAPLG00000014334	-	99	88.552	Anas_platyrhynchos
ENSG00000100201	DDX17	100	91.530	ENSANAG00000035052	DDX17	100	92.496	Aotus_nancymaae
ENSG00000100201	DDX17	71	97.500	ENSACLG00000015882	DDX17	94	75.654	Astatotilapia_calliptera
ENSG00000100201	DDX17	71	97.500	ENSACLG00000015887	si:dkey-156n14.5	93	73.865	Astatotilapia_calliptera
ENSG00000100201	DDX17	98	100.000	ENSBTAG00000009887	DDX17	100	99.692	Bos_taurus
ENSG00000100201	DDX17	71	72.500	WBGene00010260	ddx-17	79	60.497	Caenorhabditis_elegans
ENSG00000100201	DDX17	98	100.000	ENSCJAG00000011797	DDX17	100	99.846	Callithrix_jacchus
ENSG00000100201	DDX17	97	99.295	ENSCAFG00000001395	DDX17	100	99.846	Canis_familiaris
ENSG00000100201	DDX17	98	100.000	ENSCAFG00020002867	DDX17	100	99.846	Canis_lupus_dingo
ENSG00000100201	DDX17	100	99.314	ENSCHIG00000021332	DDX17	100	99.314	Capra_hircus
ENSG00000100201	DDX17	100	98.769	ENSTSYG00000001303	DDX17	99	98.769	Carlito_syrichta
ENSG00000100201	DDX17	100	99.314	ENSCPOG00000011790	DDX17	100	99.314	Cavia_porcellus
ENSG00000100201	DDX17	98	100.000	ENSCCAG00000024116	DDX17	100	100.000	Cebus_capucinus
ENSG00000100201	DDX17	100	100.000	ENSCATG00000035701	DDX17	99	100.000	Cercocebus_atys
ENSG00000100201	DDX17	98	100.000	ENSCLAG00000017294	DDX17	100	99.540	Chinchilla_lanigera
ENSG00000100201	DDX17	89	100.000	ENSCSAG00000006649	DDX17	100	100.000	Chlorocebus_sabaeus
ENSG00000100201	DDX17	100	97.942	ENSCHOG00000001931	DDX17	100	97.942	Choloepus_hoffmanni
ENSG00000100201	DDX17	63	71.429	ENSCING00000008750	-	82	45.781	Ciona_intestinalis
ENSG00000100201	DDX17	71	92.500	ENSCING00000004147	-	90	62.715	Ciona_intestinalis
ENSG00000100201	DDX17	100	99.863	ENSCANG00000002348	DDX17	100	99.863	Colobus_angolensis_palliatus
ENSG00000100201	DDX17	89	99.080	ENSCGRG00001023050	Ddx17	100	99.080	Cricetulus_griseus_chok1gshd
ENSG00000100201	DDX17	89	99.080	ENSCGRG00000007756	Ddx17	100	99.080	Cricetulus_griseus_crigri
ENSG00000100201	DDX17	75	95.238	ENSCSEG00000011351	si:dkey-156n14.5	91	89.125	Cynoglossus_semilaevis
ENSG00000100201	DDX17	71	97.500	ENSCVAG00000010921	si:dkey-156n14.5	95	73.035	Cyprinodon_variegatus
ENSG00000100201	DDX17	73	97.561	ENSDARG00000010873	DDX17	91	89.125	Danio_rerio
ENSG00000100201	DDX17	99	98.755	ENSDNOG00000006499	DDX17	99	98.755	Dasypus_novemcinctus
ENSG00000100201	DDX17	100	96.296	ENSDORG00000003358	Ddx17	100	99.233	Dipodomys_ordii
ENSG00000100201	DDX17	75	66.667	FBgn0035720	CG10077	78	65.768	Drosophila_melanogaster
ENSG00000100201	DDX17	56	95.333	ENSETEG00000009484	-	63	95.070	Echinops_telfairi
ENSG00000100201	DDX17	89	99.538	ENSEASG00005018767	DDX17	100	99.538	Equus_asinus_asinus
ENSG00000100201	DDX17	98	100.000	ENSECAG00000025110	DDX17	100	99.538	Equus_caballus
ENSG00000100201	DDX17	100	99.316	ENSFCAG00000031570	DDX17	96	100.000	Felis_catus
ENSG00000100201	DDX17	85	88.854	ENSFALG00000012560	DDX17	84	88.264	Ficedula_albicollis
ENSG00000100201	DDX17	87	99.370	ENSFDAG00000009967	DDX17	100	99.370	Fukomys_damarensis
ENSG00000100201	DDX17	87	89.252	ENSGALG00000037360	DDX17	95	88.462	Gallus_gallus
ENSG00000100201	DDX17	71	95.000	ENSGACG00000019151	si:dkey-156n14.5	85	69.759	Gasterosteus_aculeatus
ENSG00000100201	DDX17	100	100.000	ENSGGOG00000008309	DDX17	100	100.000	Gorilla_gorilla
ENSG00000100201	DDX17	71	97.500	ENSHBUG00000021303	si:dkey-156n14.5	93	73.709	Haplochromis_burtoni
ENSG00000100201	DDX17	71	97.500	ENSHBUG00000022268	DDX17	94	75.367	Haplochromis_burtoni
ENSG00000100201	DDX17	100	98.903	ENSHGLG00000012568	DDX17	100	98.903	Heterocephalus_glaber_female
ENSG00000100201	DDX17	100	98.903	ENSHGLG00100011291	DDX17	100	98.903	Heterocephalus_glaber_male
ENSG00000100201	DDX17	73	97.561	ENSIPUG00000015768	si:dkey-156n14.5	94	89.920	Ictalurus_punctatus
ENSG00000100201	DDX17	100	99.177	ENSSTOG00000013699	DDX17	100	99.177	Ictidomys_tridecemlineatus
ENSG00000100201	DDX17	99	98.483	ENSJJAG00000011350	Ddx17	100	98.483	Jaculus_jaculus
ENSG00000100201	DDX17	100	99.863	ENSMFAG00000046051	DDX17	99	100.000	Macaca_fascicularis
ENSG00000100201	DDX17	100	99.863	ENSMMUG00000004304	DDX17	100	99.863	Macaca_mulatta
ENSG00000100201	DDX17	100	99.863	ENSMNEG00000022218	DDX17	99	100.000	Macaca_nemestrina
ENSG00000100201	DDX17	98	100.000	ENSMLEG00000029141	DDX17	99	100.000	Mandrillus_leucophaeus
ENSG00000100201	DDX17	71	97.500	ENSMAMG00000008427	si:dkey-156n14.5	93	73.034	Mastacembelus_armatus
ENSG00000100201	DDX17	71	97.500	ENSMZEG00005009937	si:dkey-156n14.5	93	73.865	Maylandia_zebra
ENSG00000100201	DDX17	87	89.286	ENSMGAG00000012423	DDX17	86	98.876	Meleagris_gallopavo
ENSG00000100201	DDX17	98	67.273	ENSMAUG00000020476	Ddx17	86	88.827	Mesocricetus_auratus
ENSG00000100201	DDX17	100	99.042	ENSMICG00000011601	DDX17	100	99.042	Microcebus_murinus
ENSG00000100201	DDX17	98	95.119	ENSMOCG00000010769	Ddx17	100	95.119	Microtus_ochrogaster
ENSG00000100201	DDX17	73	95.122	ENSMMOG00000007416	si:dkey-156n14.5	89	87.664	Mola_mola
ENSG00000100201	DDX17	80	91.111	ENSMMOG00000002806	-	91	88.594	Mola_mola
ENSG00000100201	DDX17	83	97.521	ENSMODG00000009681	DDX17	97	97.521	Monodelphis_domestica
ENSG00000100201	DDX17	71	97.500	ENSMALG00000002485	si:dkey-156n14.5	95	72.981	Monopterus_albus
ENSG00000100201	DDX17	89	98.773	MGP_CAROLIEiJ_G0020017	Ddx17	100	98.773	Mus_caroli
ENSG00000100201	DDX17	98	100.000	ENSMUSG00000055065	Ddx17	100	98.773	Mus_musculus
ENSG00000100201	DDX17	89	98.466	MGP_PahariEiJ_G0020019	Ddx17	100	98.466	Mus_pahari
ENSG00000100201	DDX17	89	98.773	MGP_SPRETEiJ_G0020915	Ddx17	100	98.773	Mus_spretus
ENSG00000100201	DDX17	89	99.846	ENSMPUG00000013125	DDX17	100	99.846	Mustela_putorius_furo
ENSG00000100201	DDX17	82	95.522	ENSMLUG00000013151	DDX17	91	95.462	Myotis_lucifugus
ENSG00000100201	DDX17	89	98.773	ENSNGAG00000004001	Ddx17	100	98.773	Nannospalax_galili
ENSG00000100201	DDX17	73	97.561	ENSNBRG00000002592	DDX17	87	89.005	Neolamprologus_brichardi
ENSG00000100201	DDX17	73	97.561	ENSNBRG00000020059	-	93	86.329	Neolamprologus_brichardi
ENSG00000100201	DDX17	98	100.000	ENSNLEG00000015117	DDX17	99	100.000	Nomascus_leucogenys
ENSG00000100201	DDX17	87	89.100	ENSMEUG00000009627	DDX17	100	89.100	Notamacropus_eugenii
ENSG00000100201	DDX17	100	98.765	ENSOPRG00000014734	DDX17	100	98.765	Ochotona_princeps
ENSG00000100201	DDX17	99	95.885	ENSODEG00000013118	DDX17	100	95.885	Octodon_degus
ENSG00000100201	DDX17	73	97.561	ENSONIG00000018880	si:dkey-156n14.5	91	89.390	Oreochromis_niloticus
ENSG00000100201	DDX17	89	99.385	ENSOCUG00000004982	DDX17	100	99.385	Oryctolagus_cuniculus
ENSG00000100201	DDX17	71	97.500	ENSORLG00000013685	si:dkey-156n14.5	93	73.132	Oryzias_latipes
ENSG00000100201	DDX17	71	97.500	ENSORLG00020021743	si:dkey-156n14.5	93	72.973	Oryzias_latipes_hni
ENSG00000100201	DDX17	71	97.500	ENSORLG00015022548	si:dkey-156n14.5	93	73.291	Oryzias_latipes_hsok
ENSG00000100201	DDX17	71	97.500	ENSOMEG00000009515	si:dkey-156n14.5	96	74.086	Oryzias_melastigma
ENSG00000100201	DDX17	89	99.387	ENSOGAG00000001539	DDX17	100	99.387	Otolemur_garnettii
ENSG00000100201	DDX17	87	99.684	ENSOARG00000015489	DDX17	100	99.684	Ovis_aries
ENSG00000100201	DDX17	100	100.000	ENSPPAG00000042301	DDX17	100	100.000	Pan_paniscus
ENSG00000100201	DDX17	100	99.316	ENSPPRG00000008444	DDX17	97	99.316	Panthera_pardus
ENSG00000100201	DDX17	98	100.000	ENSPTIG00000008733	DDX17	99	93.568	Panthera_tigris_altaica
ENSG00000100201	DDX17	100	100.000	ENSPTRG00000014369	DDX17	100	100.000	Pan_troglodytes
ENSG00000100201	DDX17	100	99.181	ENSPANG00000015143	DDX17	100	99.181	Papio_anubis
ENSG00000100201	DDX17	71	97.500	ENSPKIG00000002575	si:dkey-156n14.5	94	75.583	Paramormyrops_kingsleyae
ENSG00000100201	DDX17	71	97.500	ENSPKIG00000007831	DDX17	94	72.727	Paramormyrops_kingsleyae
ENSG00000100201	DDX17	89	98.160	ENSPEMG00000021115	Ddx17	100	98.160	Peromyscus_maniculatus_bairdii
ENSG00000100201	DDX17	89	98.000	ENSPCIG00000001652	DDX17	100	98.000	Phascolarctos_cinereus
ENSG00000100201	DDX17	71	97.500	ENSPREG00000000506	si:dkey-156n14.5	92	74.522	Poecilia_reticulata
ENSG00000100201	DDX17	89	100.000	ENSPPYG00000011821	DDX17	100	100.000	Pongo_abelii
ENSG00000100201	DDX17	99	97.787	ENSPCAG00000011672	DDX17	100	97.787	Procavia_capensis
ENSG00000100201	DDX17	100	99.179	ENSPCOG00000014360	DDX17	100	99.179	Propithecus_coquereli
ENSG00000100201	DDX17	100	99.314	ENSPVAG00000010133	DDX17	100	99.314	Pteropus_vampyrus
ENSG00000100201	DDX17	71	97.500	ENSPNYG00000019669	-	94	74.878	Pundamilia_nyererei
ENSG00000100201	DDX17	71	97.500	ENSPNYG00000005694	si:dkey-156n14.5	93	73.594	Pundamilia_nyererei
ENSG00000100201	DDX17	73	97.561	ENSPNAG00000029948	si:dkey-156n14.5	91	90.451	Pygocentrus_nattereri
ENSG00000100201	DDX17	89	99.080	ENSRNOG00000051170	Ddx17	100	99.080	Rattus_norvegicus
ENSG00000100201	DDX17	100	99.863	ENSRBIG00000031437	DDX17	100	99.863	Rhinopithecus_bieti
ENSG00000100201	DDX17	98	100.000	ENSRROG00000045378	DDX17	100	100.000	Rhinopithecus_roxellana
ENSG00000100201	DDX17	71	70.000	YNL112W	-	81	61.451	Saccharomyces_cerevisiae
ENSG00000100201	DDX17	100	91.929	ENSSBOG00000024547	DDX17	100	91.929	Saimiri_boliviensis_boliviensis
ENSG00000100201	DDX17	87	97.950	ENSSHAG00000004578	DDX17	100	97.950	Sarcophilus_harrisii
ENSG00000100201	DDX17	71	97.500	ENSSFOG00015012308	ddx17	95	74.807	Scleropages_formosus
ENSG00000100201	DDX17	71	97.500	ENSSMAG00000005509	DDX17	94	75.845	Scophthalmus_maximus
ENSG00000100201	DDX17	71	97.500	ENSSMAG00000007794	si:dkey-156n14.5	93	70.382	Scophthalmus_maximus
ENSG00000100201	DDX17	75	95.238	ENSSPAG00000019808	-	93	89.390	Stegastes_partitus
ENSG00000100201	DDX17	71	97.500	ENSSPAG00000017130	si:dkey-156n14.5	93	74.722	Stegastes_partitus
ENSG00000100201	DDX17	98	100.000	ENSSSCG00000000104	DDX17	100	99.692	Sus_scrofa
ENSG00000100201	DDX17	87	89.515	ENSTGUG00000010391	DDX17	95	88.567	Taeniopygia_guttata
ENSG00000100201	DDX17	71	95.000	ENSTRUG00000021931	si:dkey-156n14.5	93	73.760	Takifugu_rubripes
ENSG00000100201	DDX17	87	98.420	ENSTTRG00000005623	DDX17	100	98.420	Tursiops_truncatus
ENSG00000100201	DDX17	100	96.990	ENSUAMG00000007290	DDX17	100	96.990	Ursus_americanus
ENSG00000100201	DDX17	100	92.593	ENSVPAG00000001476	DDX17	100	92.593	Vicugna_pacos
ENSG00000100201	DDX17	98	100.000	ENSVVUG00000022762	DDX17	96	100.000	Vulpes_vulpes
ENSG00000100201	DDX17	71	92.500	ENSXETG00000006900	ddx17	94	78.317	Xenopus_tropicalis
ENSG00000100201	DDX17	71	97.500	ENSXMAG00000005078	si:dkey-156n14.5	92	74.363	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000380	alternative mRNA splicing, via spliceosome	24275493.24910439.	IMP	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	23022728.	IMP	Process
GO:0001837	epithelial to mesenchymal transition	24910439.	IMP	Process
GO:0003713	transcription coactivator activity	17226766.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003724	RNA helicase activity	8871553.	TAS	Function
GO:0005515	protein binding	14559993.15298701.15660129.16189514.18279852.18334637.21876179.22266867.22365833.22407013.24581491.24910439.24965446.25416956.26420826.26871637.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	24910439.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	24275493.	IMP	Process
GO:0006364	rRNA processing	-	IEA	Process
GO:0006396	RNA processing	8871553.	TAS	Process
GO:0008186	RNA-dependent ATPase activity	8871553.	TAS	Function
GO:0010586	miRNA metabolic process	27478153.	IMP	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0030520	intracellular estrogen receptor signaling pathway	24275493.	IMP	Process
GO:0030521	androgen receptor signaling pathway	24275493.	IMP	Process
GO:0031047	gene silencing by RNA	-	IEA	Process
GO:0045445	myoblast differentiation	-	ISS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	17226766.	IDA	Process
GO:0051607	defense response to virus	-	IEA	Process
GO:2001014	regulation of skeletal muscle cell differentiation	17011493.	IMP	Process

EuRBPDB

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Description

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GWAS

PPI

Paralogs

Orthologs

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.