EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20694513	MCM-2 and MCM-5 expression in gastric adenocarcinoma: clinical significance and comparison with Ki-67 proliferative marker.	Dig Dis Sci	2011 Mar	Giaginis C	doi: 10.1007/s10620-010-1348-5
27140445	Cancer-specific promoters for expression-targeted gene therapy: ran, brms1 and mcm5.	J Gene Med	2016 Jul	Chen X	doi: 10.1002/jgm.2882.
19130399	Analysis of pRb, p16INK4A proteins and proliferating antigens: PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor).	Histol Histopathol	2009 Mar	Stalinska L	doi: 10.14670/HH-24.299.
29871972	MiR-362-3p functions as a tumor suppressor through targeting MCM5 in cervical adenocarcinoma.	Biosci Rep	2018 Jun 21	Wang D	doi: 10.1042/BSR20180668
21106093	Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts.	BMC Cancer	2010 Nov 24	Brems-Eskildsen AS	doi: 10.1186/1471-2407-10-646.
25596707	MicroRNA-10b and minichromosome maintenance complex component 5 gene as prognostic biomarkers in breast cancer.	Tumour Biol	2015 Jun	Eissa S	doi: 10.1007/s13277-015-3090-2
18465232	Clinical significance of MCM-2 and MCM-5 expression in colon cancer: association with clinicopathological parameters and tumor proliferative capacity.	Dig Dis Sci	2009 Feb	Giaginis C	doi: 10.1007/s10620-008-0305-z
29642758	Identification of Significant Gene Signatures and Prognostic Biomarkers for Patients With Cervical Cancer by Integrated Bioinformatic Methods.	Technol Cancer Res Treat	2018 Jan 1	Li X	doi: 10.1177/1533033818767455.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr22	35419953	Silent	rs374156334	S591S	0.43
BLCA	chr22	35403480	Missense_Mutation	novel	L121F	0.06
BLCA	chr22	35412514	Silent	NA	R308R	0.07
BLCA	chr22	35421621	Intron	novel		0.5
BLCA	chr22	35417780	Missense_Mutation	rs149623832	A543T	0.4
BLCA	chr22	35416636	Splice_Site	novel	X472_splice	0.22
BLCA	chr22	35400457	Missense_Mutation	novel	P7A	0.25
BLCA	chr22	35416693	Missense_Mutation	novel	S490L	0.55
BRCA	chr22	35400451	Missense_Mutation	NA	D5H	0.05
BRCA	chr22	35416645	Missense_Mutation	NA	I474T	0.47
CESC	chr22	35408409	Missense_Mutation	NA	D200N	0.27
CESC	chr22	35417780	Missense_Mutation	rs149623832	A543T	0.23
CESC	chr22	35408453	Silent	NA	I214I	0.57
CESC	chr22	35419957	Missense_Mutation	novel	A593T	0.19
CESC	chr22	35424220	Missense_Mutation	NA	R724C	0.41
CESC	chr22	35424263	3'UTR	rs375136391		0.11
COAD	chr22	35416700	Silent	rs762680535	F492F	0.39
COAD	chr22	35403509	Silent	rs372421942	S130S	0.4
COAD	chr22	35423207	Splice_Region	novel		0.2
COAD	chr22	35410810	Silent	novel	K273K	0.13
COAD	chr22	35423992	Intron	novel		0.41
COAD	chr22	35412658	Silent	novel	L356L	0.29
COAD	chr22	35412659	Missense_Mutation	novel	L357F	0.28
COAD	chr22	35416398	Silent	rs137919698	I469I	0.42
COAD	chr22	35416816	Splice_Site	novel	X530_splice	0.21
COAD	chr22	35406604	Missense_Mutation	NA	S159A	0.27
COAD	chr22	35424133	Intron	novel		0.38
COAD	chr22	35415876	Silent	rs370921899	S417S	0.08
COAD	chr22	35406647	Missense_Mutation	NA	R173H	0.3
ESCA	chr22	35403256	Nonsense_Mutation	novel	E73*	0.09
GBM	chr22	35406683	Missense_Mutation	NA	R185H	0.23
GBM	chr22	35423108	Intron	novel		0.29
GBM	chr22	35406555	Splice_Region	rs749822398	S142S	0.55
GBM	chr22	35403260	Missense_Mutation	novel	M74R	0.07
GBM	chr22	35408541	Missense_Mutation	novel	H244D	0.64
GBM	chr22	35416714	Missense_Mutation	novel	E497V	0.07
GBM	chr22	35410891	Silent	novel	Q300Q	0.11
HNSC	chr22	35408514	Missense_Mutation	novel	A235S	0.47
HNSC	chr22	35421546	Intron	novel		0.06
HNSC	chr22	35421548	Intron	novel		0.04
HNSC	chr22	35410741	Splice_Region	novel		0.07
HNSC	chr22	35421342	Silent	rs752688961	I619I	0.3
HNSC	chr22	35413941	Silent	novel	A386A	0.13
HNSC	chr22	35406591	Silent	novel	I154I	0.17
HNSC	chr22	35423356	Intron	novel		0.45
KICH	chr22	35424363	3'UTR	novel		0.47
KIRC	chr22	35419927	Missense_Mutation	NA	K583Q	0.24
KIRC	chr22	35416732	Missense_Mutation	NA	N503S	0.27
KIRP	chr22	35410784	Missense_Mutation	NA	I265V	0.31
LAML	chr22	35406709	Missense_Mutation	novel	P194S	0.13
LGG	chr22	35423232	Missense_Mutation	novel	S665N	0.13
LIHC	chr22	35416713	Missense_Mutation	NA	E497Q	0.39
LIHC	chr22	35400497	Missense_Mutation	novel	Q20R	0.06
LIHC	chr22	35406603	Silent	novel	A158A	0.47
LUAD	chr22	35406594	Silent	rs571490966	I155I	0.09
LUAD	chr22	35403303	Missense_Mutation	NA	L88F	0.21
LUAD	chr22	35406726	Splice_Site	NA	X199_splice	0.1
LUAD	chr22	35421370	Nonsense_Mutation	NA	Q629*	0.21
LUAD	chr22	35421527	Intron	novel		0.44
LUAD	chr22	35400524	Missense_Mutation	novel	S29W	0.52
LUAD	chr22	35416746	Missense_Mutation	novel	P508T	0.16
LUAD	chr22	35415875	Missense_Mutation	rs200017918	S417L	0.27
LUAD	chr22	35415839	Missense_Mutation	NA	S405C	0.11
LUAD	chr22	35421414	Silent	NA	L643L	0.29
LUAD	chr22	35421506	Intron	novel		0.27
LUAD	chr22	35408486	Missense_Mutation	rs183229097	Q225H	0.27
LUAD	chr22	35416728	Missense_Mutation	novel	D502Y	0.13
LUAD	chr22	35416674	Missense_Mutation	novel	V484F	0.18
LUAD	chr22	35413938	Silent	NA	T385T	0.13
LUAD	chr22	35410859	Nonsense_Mutation	NA	R290*	0.3
LUSC	chr22	35423258	In_Frame_Del	novel	R674_Q678del	0.42
LUSC	chr22	35417853	Missense_Mutation	rs373130534	R567L	0.2
LUSC	chr22	35403513	Missense_Mutation	novel	A132S	0.44
LUSC	chr22	35403504	Missense_Mutation	NA	K129Q	0.34
LUSC	chr22	35423435	Intron	novel		0.27
LUSC	chr22	35403261	Missense_Mutation	NA	M74I	0.1
LUSC	chr22	35400566	Missense_Mutation	NA	R43L	0.32
LUSC	chr22	35403334	Splice_Site	NA	X98_splice	0.31
LUSC	chr22	35403475	Missense_Mutation	novel	E119V	0.11
LUSC	chr22	35410748	Silent	novel	L253L	0.28
LUSC	chr22	35406629	Missense_Mutation	novel	R167L	0.11
LUSC	chr22	35410741	Splice_Region	novel		0.06
LUSC	chr22	35413894	Missense_Mutation	NA	R371S	0.48
OV	chr22	35423339	Missense_Mutation	novel	Q701E	0.06
OV	chr22	35423341	Frame_Shift_Ins	novel	*K702Sfs3**	0.05
OV	chr22	35417855	Missense_Mutation	NA	V568L	0.89
OV	chr22	35417752	Silent	novel	A533A	0.12
OV	chr22	35400462	Silent	NA	G8G	0.08
OV	chr22	35408550	Missense_Mutation	novel	L247V	0.24
OV	chr22	35423263	Silent	rs563110160	I675I	0.07
OV	chr22	35410811	Missense_Mutation	novel	F274I	0.08
OV	chr22	35406631	Missense_Mutation	novel	I168L	0.11
PAAD	chr22	35412513	Missense_Mutation	rs770164574	R308H	0.2
READ	chr22	35416767	Missense_Mutation	rs761749738	D515N	0.41
READ	chr22	35423264	Missense_Mutation	rs756439766	E676K	0.48
SARC	chr22	35403453	Missense_Mutation	rs773682520	R112W	0.31
SKCM	chr22	35406662	Missense_Mutation	novel	T178I	0.51
SKCM	chr22	35421531	Intron	novel		0.27
SKCM	chr22	35408520	Missense_Mutation	NA	P237T	0.15
SKCM	chr22	35417766	Missense_Mutation	NA	T538I	0.33
SKCM	chr22	35410737	Splice_Region	novel		0.43
SKCM	chr22	35400514	Missense_Mutation	NA	A26T	0.15
SKCM	chr22	35412661	Silent	NA	L357L	0.49
SKCM	chr22	35403491	Silent	novel	I124I	0.11
SKCM	chr22	35408459	Silent	rs200995863	P216P	0.22
SKCM	chr22	35419973	Missense_Mutation	novel	R598K	0.26
SKCM	chr22	35419974	Silent	novel	R598R	0.28
SKCM	chr22	35421580	Intron	novel		0.15
SKCM	chr22	35423202	Intron	novel		0.27
SKCM	chr22	35412538	Silent	NA	P316P	0.45
SKCM	chr22	35423149	Intron	novel		0.24
SKCM	chr22	35412556	Silent	NA	F322F	0.46
SKCM	chr22	35423407	Intron	novel		0.48
SKCM	chr22	35416700	Silent	rs762680535	F492F	0.45
SKCM	chr22	35416791	Missense_Mutation	NA	E523K	0.7
STAD	chr22	35412561	Missense_Mutation	rs757968764	R324H	0.2
STAD	chr22	35406682	Missense_Mutation	rs142715814	R185C	0.32
STAD	chr22	35415898	Missense_Mutation	rs768089056	R425W	0.38
STAD	chr22	35420011	Missense_Mutation	novel	R611W	0.33
STAD	chr22	35412661	Silent	NA	L357L	0.4
STAD	chr22	35408517	Missense_Mutation	NA	V236I	0.12
STAD	chr22	35421558	Intron	novel		0.13
STAD	chr22	35421317	Splice_Site	NA	X611_splice	0.43
STAD	chr22	35408525	Silent	novel	H238H	0.27
STAD	chr22	35406628	Missense_Mutation	rs181776514	R167C	0.22
STAD	chr22	35410788	Missense_Mutation	NA	M266T	0.23
STAD	chr22	35416355	Missense_Mutation	NA	R455H	0.43
UCEC	chr22	35412627	Missense_Mutation	NA	G346D	0.35
UCEC	chr22	35421636	Intron	novel		0.3
UCEC	chr22	35421363	Missense_Mutation	NA	M626I	0.29
UCEC	chr22	35410860	Missense_Mutation	rs779755915	R290Q	0.4
UCEC	chr22	35417833	Missense_Mutation	NA	K560N	0.44
UCEC	chr22	35403316	Missense_Mutation	rs147516607	A93T	0.47
UCEC	chr22	35416718	Silent	rs779853294	T498T	0.1
UCEC	chr22	35410659	Intron	novel		0.19
UCEC	chr22	35412628	Silent	NA	G346G	0.2
UCEC	chr22	35406683	Missense_Mutation	NA	R185H	0.29
UCEC	chr22	35408471	Silent	novel	K220K	0.06
UCEC	chr22	35423127	Intron	novel		0.27
UCEC	chr22	35416399	Missense_Mutation	rs528509244	A470T	0.21
UCEC	chr22	35424306	3'UTR	rs375070298		0.15
UCEC	chr22	35417856	Missense_Mutation	NA	V568E	0.5
UCEC	chr22	35415919	Missense_Mutation	rs760371424	G432R	0.37
UCEC	chr22	35413938	Silent	NA	T385T	0.46
UCEC	chr22	35416369	Missense_Mutation	novel	E460K	0.58
UCEC	chr22	35424309	3'UTR	novel		0.52
UCEC	chr22	35419954	Missense_Mutation	rs751790568	G592R	0.24
UCEC	chr22	35408442	Missense_Mutation	novel	P211S	0.3
UCEC	chr22	35417774	Missense_Mutation	rs138322887	V541M	0.25
UCEC	chr22	35423303	Missense_Mutation	novel	V689M	0.25
UCEC	chr22	35424363	3'UTR	novel		0.3
UCEC	chr22	35416355	Missense_Mutation	NA	R455H	0.32
UCEC	chr22	35423384	Intron	novel		0.54
UCEC	chr22	35415894	Silent	rs140049992	S423S	0.63
UCEC	chr22	35416399	Missense_Mutation	rs528509244	A470T	0.25
UCEC	chr22	35424344	3'UTR	novel		0.39
UCEC	chr22	35413944	Missense_Mutation	novel	K387N	0.26
UCEC	chr22	35415936	Silent	rs576728464	A437A	0.28
UCEC	chr22	35424281	3'UTR	novel		0.42
UCEC	chr22	35423087	Intron	novel		0.26
UCEC	chr22	35415961	Nonsense_Mutation	novel	E446*	0.24
UCEC	chr22	35421704	Intron	novel		0.4
UCEC	chr22	35403461	Silent	novel	R114R	0.29
UCEC	chr22	35416762	Missense_Mutation	novel	R513H	0.5
UCEC	chr22	35400164	5'UTR	novel		0.42
UCEC	chr22	35415962	Missense_Mutation	NA	E446G	0.39
UCEC	chr22	35403234	Frame_Shift_Del	novel	*E67Sfs40**	0.53
UCEC	chr22	35421536	Intron	novel		0.45
UCEC	chr22	35410781	Missense_Mutation	novel	T264A	0.46
UCEC	chr22	35412608	Missense_Mutation	novel	A340T	0.52
UCEC	chr22	35424150	Splice_Region	novel		0.34
UCEC	chr22	35423129	Intron	novel		0.41
UCEC	chr22	35410898	Missense_Mutation	novel	T303A	0.21
UCEC	chr22	35412608	Missense_Mutation	novel	A340T	0.51
UCEC	chr22	35423427	Intron	novel		0.35
UCEC	chr22	35423066	Intron	novel		0.4
UCEC	chr22	35406598	Missense_Mutation	rs766431719	A157T	0.43
UCEC	chr22	35410583	Intron	novel		0.27
UCEC	chr22	35419898	Missense_Mutation	novel	R573Q	0.4
UCEC	chr22	35423237	Missense_Mutation	novel	E667K	0.39
UCEC	chr22	35415900	Silent	novel	R425R	0.33
UCS	chr22	35419920	Missense_Mutation	novel	E580D	0.27
UVM	chr22	35415898	Missense_Mutation	rs768089056	R425W	0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PCPG	DEL	0.3086	0.044123
THCA	DEL	0.1563	0.046486
THYM	DEL	0.0732	0.063154

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0061	Kaplan-Meier Survival Analysis
STAD	0.02	Kaplan-Meier Survival Analysis
SARC	0.022	Kaplan-Meier Survival Analysis
MESO	0.00098	Kaplan-Meier Survival Analysis
ACC	0.0002	Kaplan-Meier Survival Analysis
UCS	0.046	Kaplan-Meier Survival Analysis
HNSC	0.05	Kaplan-Meier Survival Analysis
LUSC	0.028	Kaplan-Meier Survival Analysis
BRCA	0.035	Kaplan-Meier Survival Analysis
CESC	0.00011	Kaplan-Meier Survival Analysis
READ	0.029	Kaplan-Meier Survival Analysis
LAML	0.0013	Kaplan-Meier Survival Analysis
LIHC	0.00046	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.0033	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.011	Kaplan-Meier Survival Analysis
OV	0.038	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100297 (Gene tree)
Gene ID: 4174
Gene Symbol: MCM5
Alias: CDC46
Full Name: minichromosome maintenance complex component 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 54,827 bases
Position: chr22:35,400,063-35,454,889
Accession: 6948
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22889230	Virus-producing cells determine the host protein profiles of HIV-1 virion cores.	Retrovirology	2012 Aug 13	Santos S	doi: 10.1186/1742-4690-9-65.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000493076	MCM5-209	4599	-	-	- (aa)	-	-
ENST00000451351	MCM5-206	450	-	ENSP00000412847	57 (aa)	-	F8WFD7
ENST00000417343	MCM5-204	557	-	-	- (aa)	-	-
ENST00000382011	MCM5-202	2402	-	ENSP00000371441	691 (aa)	-	B1AHB1
ENST00000416905	MCM5-203	739	-	ENSP00000393977	230 (aa)	-	B1AHA9
ENST00000464908	MCM5-207	554	-	-	- (aa)	-	-
ENST00000493569	MCM5-210	468	-	-	- (aa)	-	-
ENST00000465557	MCM5-208	587	-	-	- (aa)	-	-
ENST00000444778	MCM5-205	551	-	ENSP00000408705	150 (aa)	-	B1AHB2
ENST00000216122	MCM5-201	3534	XM_006724242	ENSP00000216122	734 (aa)	XP_006724305	P33992

Gene Model

Click here to download ENSG00000100297's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG
hsa04110	Cell cycle	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100297	Platelet Function Tests	2.6573900E-005	-
ENSG00000100297	Platelet Function Tests	2.5606800E-005	-
ENSG00000100297	Platelet Function Tests	1.7861600E-005	-
ENSG00000100297	Platelet Function Tests	6.0396130E-014	-
ENSG00000100297	monocyte chemoattractant protein 1 (66-77)	5.2580000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000100297	rs2071743	22	35421264	A	Hippocampal volume in mild cognitive impairment	29274321	[0.32-0.72] unit decrease	0.52	EFO_0007998\|EFO_0005035

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100297's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100297	MCM5	100	59.663	WBGene00003157	mcm-5	100	59.663	Caenorhabditis_elegans
ENSG00000100297	MCM5	99	70.667	FBgn0017577	Mcm5	99	68.657	Drosophila_melanogaster
ENSG00000100297	MCM5	86	31.899	FBgn0020633	Mcm7	89	32.196	Drosophila_melanogaster
ENSG00000100297	MCM5	84	31.853	ENSG00000166508	MCM7	87	31.853	Homo_sapiens
ENSG00000100297	MCM5	73	33.824	ENSG00000076003	MCM6	67	33.333	Homo_sapiens
ENSG00000100297	MCM5	81	32.767	ENSG00000112118	MCM3	82	31.878	Homo_sapiens
ENSG00000100297	MCM5	84	31.611	ENSMUSG00000029730	Mcm7	88	31.611	Mus_musculus
ENSG00000100297	MCM5	82	32.214	ENSMUSG00000041859	Mcm3	81	31.732	Mus_musculus
ENSG00000100297	MCM5	99	46.607	YLR274W	MCM5	99	47.051	Saccharomyces_cerevisiae
ENSG00000100297	MCM5	74	33.042	YGL201C		55	33.102	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	Process
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0003688	DNA replication origin binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	12364596.15232106.16899510.17296731.19150984.19862764.21149733.22540012.23764002.24299456.25036637.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	8751386.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IEA	Component
GO:0006260	DNA replication	-	TAS	Process
GO:0006270	DNA replication initiation	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0042555	MCM complex	17296731.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.