EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25370813	Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells.	Biosci Rep	2014 Dec 12	Yu X	doi: 10.1042/BSR20140078.
26617750	Knockdown of eIF3D inhibits breast cancer cell proliferation and invasion through suppressing the Wnt/β-catenin signaling pathway.	Int J Clin Exp Pathol	2015 Sep 1	Fan Y	-
28594409	EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway.	Cell Death Dis	2017 Jun 8	Zhang F	doi: 10.1038/cddis.2017.263.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr22	36512581	Missense_Mutation	novel	R410C	0.09
BLCA	chr22	36523899	Missense_Mutation	novel	E130K	0.14
BLCA	chr22	36523959	Missense_Mutation	novel	D110H	0.42
BLCA	chr22	36526132	Splice_Site	novel		0.12
BLCA	chr22	36517414	Nonsense_Mutation	novel	E293*	0.47
BLCA	chr22	36524673	Missense_Mutation	novel	E77K	0.11
BRCA	chr22	36511657	Silent	rs371162938	C493C	0.14
BRCA	chr22	36511515	Missense_Mutation	NA	E541Q	0.29
BRCA	chr22	36524705	Missense_Mutation	novel	G66E	0.09
BRCA	chr22	36523271	Nonsense_Mutation	NA	R135*	0.13
CESC	chr22	36517307	Missense_Mutation	NA	L328F	0.37
CESC	chr22	36519536	Missense_Mutation	NA	E194Q	0.23
CESC	chr22	36516886	Intron	novel		0.27
CESC	chr22	36511752	Missense_Mutation	novel	R462C	0.29
CESC	chr22	36519497	Missense_Mutation	NA	D207N	0.32
CESC	chr22	36511527	Missense_Mutation	NA	E537Q	0.23
COAD	chr22	36520661	Missense_Mutation	rs771870770	R165C	0.4
COAD	chr22	36523271	Nonsense_Mutation	NA	R135*	0.36
COAD	chr22	36516770	Silent	rs376900932	F337F	0.08
COAD	chr22	36526101	Silent	rs776873893	P7P	0.59
COAD	chr22	36516721	Missense_Mutation	rs771000513	A354T	0.1
COAD	chr22	36510930	3'UTR	novel		0.27
COAD	chr22	36519483	Silent	rs765560023	T211T	0.38
COAD	chr22	36510858	3'UTR	novel		0.1
COAD	chr22	36524613	Nonsense_Mutation	NA	R97*	0.43
COAD	chr22	36511767	Missense_Mutation	rs774999741	V457M	0.15
COAD	chr22	36523228	Missense_Mutation	novel	K149I	0.38
COAD	chr22	36517363	Missense_Mutation	rs745920273	R310C	0.17
DLBC	chr22	36511751	Missense_Mutation	novel	R462H	0.47
ESCA	chr22	36512603	Splice_Site	novel	X403_splice	0.17
ESCA	chr22	36516608	Splice_Site	novel	X359_splice	0.14
ESCA	chr22	36524644	Silent	rs200724214	A86A	0.32
GBM	chr22	36525669	Missense_Mutation	novel	Y55S	0.07
GBM	chr22	36518804	Missense_Mutation	novel	G273V	0.09
GBM	chr22	36524698	Missense_Mutation	novel	Q68H	0.13
GBM	chr22	36511693	Missense_Mutation	novel	N481K	0.08
GBM	chr22	36523953	Missense_Mutation	rs773917881	R112W	0.4
GBM	chr22	36524643	Missense_Mutation	novel	R87C	0.22
HNSC	chr22	36516595	Nonsense_Mutation	novel	W363*	0.35
LAML	chr22	36524659	Silent	novel	Q81Q	0.03
LGG	chr22	36511559	Missense_Mutation	NA	T526I	0.14
LIHC	chr22	36524684	Missense_Mutation	NA	H73R	0.18
LIHC	chr22	36524597	Missense_Mutation	NA	Q102L	0.53
LIHC	chr22	36523264	Missense_Mutation	NA	Q137L	0.09
LUAD	chr22	36516727	Missense_Mutation	novel	E352K	0.18
LUAD	chr22	36519518	Missense_Mutation	NA	E200K	0.14
LUAD	chr22	36525679	Missense_Mutation	NA	D52N	0.65
LUAD	chr22	36510968	3'UTR	novel		0.06
LUAD	chr22	36516706	Missense_Mutation	rs779180489	R359C	0.05
LUSC	chr22	36516706	Missense_Mutation	rs779180489	R359C	0.29
LUSC	chr22	36524628	Missense_Mutation	novel	A92P	0.86
LUSC	chr22	36516711	Missense_Mutation	novel	A357G	0.04
LUSC	chr22	36516491	Missense_Mutation	novel	E398A	0.27
OV	chr22	36526038	Missense_Mutation	novel	M28I	0.06
OV	chr22	36511595	Missense_Mutation	novel	K514T	0.09
OV	chr22	36526039	Frame_Shift_Del	novel	*M28Sfs12**	0.08
OV	chr22	36520616	Frame_Shift_Ins	novel	*M180Lfs3**	0.2
OV	chr22	36520618	In_Frame_Ins	novel	Q178_L179insYLSYFACLC	0.18
OV	chr22	36511646	Missense_Mutation	novel	I497T	0.09
OV	chr22	36523976	Splice_Site	novel	X103_splice	0.09
OV	chr22	36511654	Silent	novel	V494V	0.04
PAAD	chr22	36516710	Silent	rs748577380	A357A	0.18
PAAD	chr22	36519451	Missense_Mutation	novel	R222H	0.28
PRAD	chr22	36511672	Missense_Mutation	NA	W488C	0.14
PRAD	chr22	36510923	3'UTR	novel		0.07
READ	chr22	36512527	Missense_Mutation	NA	N428D	0.13
SARC	chr22	36520606	Missense_Mutation	rs749458696	R183H	0.47
SKCM	chr22	36526081	Missense_Mutation	NA	S14L	0.33	eIF-3_zeta
SKCM	chr22	36520661	Missense_Mutation	rs771870770	R165C	0.19
SKCM	chr22	36526061	Missense_Mutation	NA	V21I	0.16	eIF-3_zeta
SKCM	chr22	36517377	Missense_Mutation	NA	S305F	0.5
SKCM	chr22	36526057	Missense_Mutation	NA	P22L	0.11	eIF-3_zeta
SKCM	chr22	36526057	Missense_Mutation	NA	P22L	0.41	eIF-3_zeta
SKCM	chr22	36512468	Silent	NA	L447L	0.22
SKCM	chr22	36516481	Silent	NA	S401S	0.37
SKCM	chr22	36512544	Missense_Mutation	novel	A422V	0.26
STAD	chr22	36523910	Missense_Mutation	novel	A126V	0.09
STAD	chr22	36520661	Missense_Mutation	rs771870770	R165C	0.26
STAD	chr22	36516529	Silent	rs117599987	N385N	0.09
THCA	chr22	36524612	Missense_Mutation	NA	R97Q	0.1
UCEC	chr22	36512464	Missense_Mutation	novel	L449F	0.28
UCEC	chr22	36523277	Missense_Mutation	novel	R133C	0.33
UCEC	chr22	36516722	Silent	novel	I353I	0.08
UCEC	chr22	36510934	3'UTR	novel		0.2
UCEC	chr22	36525998	Splice_Site	novel	X41_splice	0.08
UCEC	chr22	36516546	Missense_Mutation	rs371499563	V380I	0.21
UCEC	chr22	36520579	Missense_Mutation	NA	D192G	0.4
UCEC	chr22	36526114	Missense_Mutation	novel	K3R	0.32	eIF-3_zeta
UCEC	chr22	36520661	Missense_Mutation	rs771870770	R165C	0.44
UCEC	chr22	36517388	Silent	novel	D301D	0.16
UCEC	chr22	36518831	Missense_Mutation	novel	S264F	0.32
UCEC	chr22	36512591	Silent	rs180927702	G406G	0.35
UCEC	chr22	36518869	Silent	NA	I251I	0.41
UCEC	chr22	36523271	Nonsense_Mutation	NA	R135*	0.15
UCEC	chr22	36512509	Missense_Mutation	novel	R434W	0.07
UCEC	chr22	36523224	Missense_Mutation	novel	W150C	0.21
UCEC	chr22	36511641	Missense_Mutation	NA	M499V	0.37
UCEC	chr22	36511528	Missense_Mutation	novel	E536D	0.11
UCEC	chr22	36511775	Missense_Mutation	rs773631633	R454Q	0.4
UCEC	chr22	36526063	Missense_Mutation	rs150123971	A20V	0.27	eIF-3_zeta
UCS	chr22	36523903	Silent	novel	Q128Q	0.55

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PCPG	DEL	0.321	0.044123
THCA	DEL	0.1563	0.046486
THYM	DEL	0.0732	0.063154

Survival Analysis

Cancer	P-value	Q-value
STAD	0.048	Kaplan-Meier Survival Analysis
ACC	0.00094	Kaplan-Meier Survival Analysis
HNSC	0.0024	Kaplan-Meier Survival Analysis
PRAD	0.032	Kaplan-Meier Survival Analysis
LUSC	0.0028	Kaplan-Meier Survival Analysis
ESCA	0.027	Kaplan-Meier Survival Analysis
PAAD	0.015	Kaplan-Meier Survival Analysis
PCPG	0.0091	Kaplan-Meier Survival Analysis
READ	0.0052	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.034	Kaplan-Meier Survival Analysis
LUAD	0.014	Kaplan-Meier Survival Analysis
UVM	0.02	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000100353 (Gene tree)
Gene ID: 8664
Gene Symbol: EIF3D
Alias: eIF3-p66|eIF3-zeta|eIF3d|EIF3S7
Full Name: eukaryotic translation initiation factor 3 subunit D
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 18,587 bases
Position: chr22:36,510,850-36,529,436
Accession: 3278
RBP type: canonical RBP
Summary: Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000216190	eIF-3_zeta	PF05091.12	9.3e-217	1	1
ENSP00000385812	eIF-3_zeta	PF05091.12	9.3e-217	1	1
ENSP00000390438	eIF-3_zeta	PF05091.12	3.3e-84	1	1
ENSP00000403584	eIF-3_zeta	PF05091.12	2.9e-35	1	1
ENSP00000385212	eIF-3_zeta	PF05091.12	9.6e-29	1	1
ENSP00000487325	eIF-3_zeta	PF05091.12	1.4e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9341143	Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.	J Biol Chem	1997 Oct 24	Asano K	-
27462815	eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.	Nature	2016 Aug 4	Lee AS	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000457241	EIF3D-207	729	-	ENSP00000403584	173 (aa)	-	B0QYA6
ENST00000402116	EIF3D-202	581	-	ENSP00000385212	123 (aa)	-	B0QYA8
ENST00000455547	EIF3D-206	996	-	ENSP00000390438	269 (aa)	-	B0QYA5
ENST00000216190	EIF3D-201	2155	-	ENSP00000216190	548 (aa)	-	O15371
ENST00000432675	EIF3D-205	678	-	-	- (aa)	-	-
ENST00000462641	EIF3D-209	887	-	-	- (aa)	-	-
ENST00000478547	EIF3D-211	452	-	ENSP00000487325	49 (aa)	-	A0A0D9SGB5
ENST00000405442	EIF3D-203	1851	-	ENSP00000385812	548 (aa)	-	O15371
ENST00000496875	EIF3D-212	604	-	-	- (aa)	-	-
ENST00000458572	EIF3D-208	883	-	ENSP00000391061	105 (aa)	-	B0QYA4
ENST00000426531	EIF3D-204	710	-	-	- (aa)	-	-
ENST00000462794	EIF3D-210	764	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000100353's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000100353	Heart Rate	3.11348536831894E-6	17903306
ENSG00000100353	Potassium	9.3710000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100353's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000100353	EIF3D	100	92.529	ENSAPOG00000002054	eif3d	98	91.683	Acanthochromis_polyacanthus
ENSG00000100353	EIF3D	100	99.257	ENSAMEG00000009639	EIF3D	100	98.905	Ailuropoda_melanoleuca
ENSG00000100353	EIF3D	100	93.678	ENSACIG00000013847	eif3d	94	92.830	Amphilophus_citrinellus
ENSG00000100353	EIF3D	100	92.529	ENSAOCG00000005916	-	97	89.865	Amphiprion_ocellaris
ENSG00000100353	EIF3D	100	91.870	ENSAOCG00000022455	eif3d	96	91.917	Amphiprion_ocellaris
ENSG00000100353	EIF3D	100	91.870	ENSAPEG00000020361	eif3d	96	91.917	Amphiprion_percula
ENSG00000100353	EIF3D	100	91.870	ENSATEG00000020784	eif3d	96	92.105	Anabas_testudineus
ENSG00000100353	EIF3D	100	95.935	ENSAPLG00000002632	EIF3D	99	88.491	Anas_platyrhynchos
ENSG00000100353	EIF3D	100	94.798	ENSACAG00000016308	EIF3D	97	95.463	Anolis_carolinensis
ENSG00000100353	EIF3D	100	100.000	ENSANAG00000026835	EIF3D	100	100.000	Aotus_nancymaae
ENSG00000100353	EIF3D	85	87.640	ENSACLG00000021430	EIF3D	89	91.791	Astatotilapia_calliptera
ENSG00000100353	EIF3D	100	93.678	ENSACLG00000021167	eif3d	97	92.453	Astatotilapia_calliptera
ENSG00000100353	EIF3D	85	87.640	ENSACLG00000021852	eif3d	81	91.791	Astatotilapia_calliptera
ENSG00000100353	EIF3D	85	87.640	ENSACLG00000021768	EIF3D	81	91.791	Astatotilapia_calliptera
ENSG00000100353	EIF3D	85	87.640	ENSACLG00000021712	eif3d	78	91.791	Astatotilapia_calliptera
ENSG00000100353	EIF3D	100	91.870	ENSAMXG00000017547	eif3d	96	91.165	Astyanax_mexicanus
ENSG00000100353	EIF3D	100	99.270	ENSBTAG00000001988	EIF3D	100	99.270	Bos_taurus
ENSG00000100353	EIF3D	96	44.704	WBGene00001227	eif-3.D	97	45.063	Caenorhabditis_elegans
ENSG00000100353	EIF3D	100	100.000	ENSCJAG00000013831	EIF3D	100	100.000	Callithrix_jacchus
ENSG00000100353	EIF3D	100	99.257	ENSCAFG00000001544	EIF3D	100	99.088	Canis_familiaris
ENSG00000100353	EIF3D	100	99.257	ENSCAFG00020004483	EIF3D	100	99.088	Canis_lupus_dingo
ENSG00000100353	EIF3D	100	99.270	ENSCHIG00000012106	EIF3D	100	99.270	Capra_hircus
ENSG00000100353	EIF3D	100	100.000	ENSTSYG00000008540	EIF3D	100	99.818	Carlito_syrichta
ENSG00000100353	EIF3D	99	96.881	ENSCAPG00000015164	EIF3D	97	96.881	Cavia_aperea
ENSG00000100353	EIF3D	100	98.905	ENSCPOG00000002529	EIF3D	100	98.905	Cavia_porcellus
ENSG00000100353	EIF3D	100	100.000	ENSCCAG00000027331	EIF3D	100	100.000	Cebus_capucinus
ENSG00000100353	EIF3D	100	100.000	ENSCATG00000045003	EIF3D	100	100.000	Cercocebus_atys
ENSG00000100353	EIF3D	100	98.723	ENSCLAG00000016545	EIF3D	100	98.723	Chinchilla_lanigera
ENSG00000100353	EIF3D	100	100.000	ENSCSAG00000007898	EIF3D	100	100.000	Chlorocebus_sabaeus
ENSG00000100353	EIF3D	100	98.374	ENSCHOG00000004811	EIF3D	99	95.788	Choloepus_hoffmanni
ENSG00000100353	EIF3D	100	96.748	ENSCPBG00000016309	EIF3D	97	96.597	Chrysemys_picta_bellii
ENSG00000100353	EIF3D	96	65.177	ENSCING00000003680	-	96	65.306	Ciona_intestinalis
ENSG00000100353	EIF3D	99	62.057	ENSCSAVG00000001450	-	89	70.000	Ciona_savignyi
ENSG00000100353	EIF3D	100	100.000	ENSCANG00000031179	EIF3D	100	100.000	Colobus_angolensis_palliatus
ENSG00000100353	EIF3D	100	98.885	ENSCGRG00001016584	EIF3D	100	98.723	Cricetulus_griseus_chok1gshd
ENSG00000100353	EIF3D	100	98.885	ENSCGRG00000000302	EIF3D	100	98.723	Cricetulus_griseus_crigri
ENSG00000100353	EIF3D	100	92.529	ENSCSEG00000020548	eif3d	96	91.698	Cynoglossus_semilaevis
ENSG00000100353	EIF3D	85	86.517	ENSCVAG00000001999	eif3d	84	92.857	Cyprinodon_variegatus
ENSG00000100353	EIF3D	100	91.954	ENSDARG00000021257	eif3d	100	90.244	Danio_rerio
ENSG00000100353	EIF3D	100	98.374	ENSDNOG00000018482	EIF3D	92	98.252	Dasypus_novemcinctus
ENSG00000100353	EIF3D	100	99.088	ENSDORG00000010491	Eif3d	100	99.088	Dipodomys_ordii
ENSG00000100353	EIF3D	98	54.364	FBgn0037994	eIF3d2	96	54.259	Drosophila_melanogaster
ENSG00000100353	EIF3D	96	58.824	FBgn0040227	eIF3d1	93	58.790	Drosophila_melanogaster
ENSG00000100353	EIF3D	100	97.110	ENSETEG00000002070	-	99	82.150	Echinops_telfairi
ENSG00000100353	EIF3D	85	84.906	ENSETEG00000009404	-	80	84.906	Echinops_telfairi
ENSG00000100353	EIF3D	77	80.247	ENSETEG00000020233	-	100	61.053	Echinops_telfairi
ENSG00000100353	EIF3D	77	83.951	ENSETEG00000016315	-	81	84.848	Echinops_telfairi
ENSG00000100353	EIF3D	85	85.393	ENSEBUG00000009405	eif3d	93	81.772	Eptatretus_burgeri
ENSG00000100353	EIF3D	100	99.257	ENSEASG00005018906	EIF3D	100	99.088	Equus_asinus_asinus
ENSG00000100353	EIF3D	100	98.540	ENSECAG00000022413	EIF3D	100	98.540	Equus_caballus
ENSG00000100353	EIF3D	97	89.414	ENSEEUG00000015771	EIF3D	97	89.414	Erinaceus_europaeus
ENSG00000100353	EIF3D	100	91.379	ENSELUG00000018698	eif3d	96	91.887	Esox_lucius
ENSG00000100353	EIF3D	100	99.453	ENSFCAG00000001131	EIF3D	100	99.453	Felis_catus
ENSG00000100353	EIF3D	100	94.815	ENSFALG00000013012	EIF3D	97	95.660	Ficedula_albicollis
ENSG00000100353	EIF3D	100	98.723	ENSFDAG00000004352	EIF3D	100	98.723	Fukomys_damarensis
ENSG00000100353	EIF3D	100	91.954	ENSGMOG00000013341	eif3d	97	90.189	Gadus_morhua
ENSG00000100353	EIF3D	100	95.185	ENSGALG00000012529	EIF3D	97	95.849	Gallus_gallus
ENSG00000100353	EIF3D	100	92.529	ENSGACG00000014538	eif3d	97	91.132	Gasterosteus_aculeatus
ENSG00000100353	EIF3D	100	96.748	ENSGAGG00000009617	EIF3D	97	96.597	Gopherus_agassizii
ENSG00000100353	EIF3D	100	100.000	ENSGGOG00000003428	EIF3D	100	100.000	Gorilla_gorilla
ENSG00000100353	EIF3D	100	92.683	ENSHBUG00000017230	eif3d	98	91.876	Haplochromis_burtoni
ENSG00000100353	EIF3D	100	87.361	ENSHGLG00000006449	-	98	83.176	Heterocephalus_glaber_female
ENSG00000100353	EIF3D	100	86.617	ENSHGLG00000000135	-	96	78.639	Heterocephalus_glaber_female
ENSG00000100353	EIF3D	100	98.905	ENSHGLG00000016422	-	100	98.905	Heterocephalus_glaber_female
ENSG00000100353	EIF3D	100	86.617	ENSHGLG00100001321	-	96	83.176	Heterocephalus_glaber_male
ENSG00000100353	EIF3D	100	98.905	ENSHGLG00100007477	-	100	98.905	Heterocephalus_glaber_male
ENSG00000100353	EIF3D	100	86.989	ENSHGLG00100013710	-	98	82.987	Heterocephalus_glaber_male
ENSG00000100353	EIF3D	100	91.954	ENSHCOG00000007799	eif3d	96	91.887	Hippocampus_comes
ENSG00000100353	EIF3D	100	92.529	ENSIPUG00000017267	eif3d	96	90.789	Ictalurus_punctatus
ENSG00000100353	EIF3D	100	99.270	ENSSTOG00000011335	EIF3D	100	99.270	Ictidomys_tridecemlineatus
ENSG00000100353	EIF3D	100	98.885	ENSJJAG00000010854	Eif3d	100	98.723	Jaculus_jaculus
ENSG00000100353	EIF3D	100	92.683	ENSKMAG00000007133	eif3d	96	92.293	Kryptolebias_marmoratus
ENSG00000100353	EIF3D	100	93.103	ENSLBEG00000005296	eif3d	96	92.075	Labrus_bergylta
ENSG00000100353	EIF3D	97	88.722	ENSLACG00000001606	EIF3D	95	88.722	Latimeria_chalumnae
ENSG00000100353	EIF3D	100	98.885	ENSLAFG00000001714	EIF3D	100	96.533	Loxodonta_africana
ENSG00000100353	EIF3D	100	100.000	ENSMFAG00000000481	EIF3D	100	100.000	Macaca_fascicularis
ENSG00000100353	EIF3D	100	100.000	ENSMMUG00000012754	EIF3D	100	100.000	Macaca_mulatta
ENSG00000100353	EIF3D	100	100.000	ENSMNEG00000012843	EIF3D	100	100.000	Macaca_nemestrina
ENSG00000100353	EIF3D	100	100.000	ENSMLEG00000037251	EIF3D	100	100.000	Mandrillus_leucophaeus
ENSG00000100353	EIF3D	100	92.529	ENSMAMG00000020219	eif3d	96	92.264	Mastacembelus_armatus
ENSG00000100353	EIF3D	100	92.683	ENSMZEG00005023294	eif3d	97	92.105	Maylandia_zebra
ENSG00000100353	EIF3D	97	87.617	ENSMZEG00005024006	eif3d	96	87.617	Maylandia_zebra
ENSG00000100353	EIF3D	100	95.539	ENSMGAG00000012653	EIF3D	100	95.932	Meleagris_gallopavo
ENSG00000100353	EIF3D	100	98.905	ENSMAUG00000013161	Eif3d	100	98.905	Mesocricetus_auratus
ENSG00000100353	EIF3D	100	99.453	ENSMICG00000012161	EIF3D	100	99.453	Microcebus_murinus
ENSG00000100353	EIF3D	100	98.885	ENSMOCG00000011605	Eif3d	100	98.723	Microtus_ochrogaster
ENSG00000100353	EIF3D	100	92.529	ENSMMOG00000021496	eif3d	96	92.075	Mola_mola
ENSG00000100353	EIF3D	100	98.141	ENSMODG00000000821	EIF3D	99	97.802	Monodelphis_domestica
ENSG00000100353	EIF3D	100	91.057	ENSMALG00000019436	eif3d	96	92.293	Monopterus_albus
ENSG00000100353	EIF3D	100	98.905	MGP_CAROLIEiJ_G0019973	Eif3d	100	98.905	Mus_caroli
ENSG00000100353	EIF3D	100	98.905	ENSMUSG00000016554	Eif3d	100	98.905	Mus_musculus
ENSG00000100353	EIF3D	100	98.723	MGP_PahariEiJ_G0019975	Eif3d	100	98.723	Mus_pahari
ENSG00000100353	EIF3D	100	98.905	MGP_SPRETEiJ_G0020871	Eif3d	100	98.905	Mus_spretus
ENSG00000100353	EIF3D	52	95.312	ENSMPUG00000012581	EIF3D	100	61.947	Mustela_putorius_furo
ENSG00000100353	EIF3D	100	98.905	ENSMLUG00000015857	EIF3D	100	98.905	Myotis_lucifugus
ENSG00000100353	EIF3D	100	98.905	ENSNGAG00000012038	Eif3d	100	98.905	Nannospalax_galili
ENSG00000100353	EIF3D	100	100.000	ENSNLEG00000014560	EIF3D	100	100.000	Nomascus_leucogenys
ENSG00000100353	EIF3D	100	98.141	ENSMEUG00000004561	EIF3D	99	98.158	Notamacropus_eugenii
ENSG00000100353	EIF3D	85	95.506	ENSOPRG00000006924	EIF3D	96	93.008	Ochotona_princeps
ENSG00000100353	EIF3D	100	99.088	ENSODEG00000011039	EIF3D	100	99.088	Octodon_degus
ENSG00000100353	EIF3D	100	93.678	ENSONIG00000009713	eif3d	96	92.642	Oreochromis_niloticus
ENSG00000100353	EIF3D	100	97.561	ENSOANG00000007483	EIF3D	99	85.478	Ornithorhynchus_anatinus
ENSG00000100353	EIF3D	100	98.723	ENSOCUG00000006363	EIF3D	100	98.723	Oryctolagus_cuniculus
ENSG00000100353	EIF3D	100	88.889	ENSORLG00000001449	eif3d	96	90.943	Oryzias_latipes
ENSG00000100353	EIF3D	100	90.809	ENSORLG00020000383	eif3d	95	91.917	Oryzias_latipes_hni
ENSG00000100353	EIF3D	100	89.219	ENSORLG00020013943	eif3d	99	88.055	Oryzias_latipes_hni
ENSG00000100353	EIF3D	100	91.908	ENSORLG00015006930	eif3d	90	91.958	Oryzias_latipes_hsok
ENSG00000100353	EIF3D	100	89.219	ENSORLG00015006954	eif3d	99	86.333	Oryzias_latipes_hsok
ENSG00000100353	EIF3D	100	86.989	ENSOMEG00000017372	eif3d	95	87.063	Oryzias_melastigma
ENSG00000100353	EIF3D	100	87.732	ENSOMEG00000017337	eif3d	95	87.762	Oryzias_melastigma
ENSG00000100353	EIF3D	100	99.270	ENSOGAG00000002978	EIF3D	100	99.270	Otolemur_garnettii
ENSG00000100353	EIF3D	100	99.270	ENSOARG00000018926	EIF3D	100	99.270	Ovis_aries
ENSG00000100353	EIF3D	100	100.000	ENSPPAG00000031183	EIF3D	100	100.000	Pan_paniscus
ENSG00000100353	EIF3D	100	99.453	ENSPPRG00000007244	EIF3D	100	99.453	Panthera_pardus
ENSG00000100353	EIF3D	100	99.257	ENSPTIG00000012272	EIF3D	100	98.358	Panthera_tigris_altaica
ENSG00000100353	EIF3D	100	100.000	ENSPTRG00000014313	EIF3D	100	100.000	Pan_troglodytes
ENSG00000100353	EIF3D	100	100.000	ENSPANG00000023980	EIF3D	100	100.000	Papio_anubis
ENSG00000100353	EIF3D	100	92.529	ENSPKIG00000013892	eif3d	96	92.830	Paramormyrops_kingsleyae
ENSG00000100353	EIF3D	100	96.748	ENSPSIG00000010983	EIF3D	97	96.597	Pelodiscus_sinensis
ENSG00000100353	EIF3D	100	91.870	ENSPMGG00000004524	eif3d	98	87.938	Periophthalmus_magnuspinnatus
ENSG00000100353	EIF3D	100	98.905	ENSPEMG00000014069	Eif3d	100	98.905	Peromyscus_maniculatus_bairdii
ENSG00000100353	EIF3D	100	79.853	ENSPMAG00000008165	eif3d	97	81.034	Petromyzon_marinus
ENSG00000100353	EIF3D	100	98.141	ENSPCIG00000021563	EIF3D	99	98.168	Phascolarctos_cinereus
ENSG00000100353	EIF3D	100	91.870	ENSPFOG00000007516	eif3d	96	92.105	Poecilia_formosa
ENSG00000100353	EIF3D	100	92.529	ENSPLAG00000015253	eif3d	96	92.105	Poecilia_latipinna
ENSG00000100353	EIF3D	100	91.870	ENSPMEG00000019987	eif3d	96	91.917	Poecilia_mexicana
ENSG00000100353	EIF3D	100	100.000	ENSPPYG00000011774	EIF3D	97	91.871	Pongo_abelii
ENSG00000100353	EIF3D	100	98.844	ENSPCAG00000007788	EIF3D	87	99.306	Procavia_capensis
ENSG00000100353	EIF3D	100	98.374	ENSPCOG00000014552	EIF3D	100	94.891	Propithecus_coquereli
ENSG00000100353	EIF3D	100	99.088	ENSPVAG00000002014	EIF3D	100	99.088	Pteropus_vampyrus
ENSG00000100353	EIF3D	100	92.683	ENSPNYG00000011917	eif3d	97	91.917	Pundamilia_nyererei
ENSG00000100353	EIF3D	100	91.477	ENSPNAG00000000176	eif3d	96	91.353	Pygocentrus_nattereri
ENSG00000100353	EIF3D	100	98.905	ENSRNOG00000005804	Eif3d	100	98.905	Rattus_norvegicus
ENSG00000100353	EIF3D	100	100.000	ENSRBIG00000041563	EIF3D	100	100.000	Rhinopithecus_bieti
ENSG00000100353	EIF3D	100	100.000	ENSRROG00000039588	EIF3D	100	100.000	Rhinopithecus_roxellana
ENSG00000100353	EIF3D	100	100.000	ENSSBOG00000032811	EIF3D	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000100353	EIF3D	100	98.141	ENSSHAG00000011209	EIF3D	99	97.619	Sarcophilus_harrisii
ENSG00000100353	EIF3D	100	93.496	ENSSFOG00015023800	eif3d	96	92.857	Scleropages_formosus
ENSG00000100353	EIF3D	100	92.529	ENSSMAG00000013962	eif3d	96	91.698	Scophthalmus_maximus
ENSG00000100353	EIF3D	100	92.683	ENSSDUG00000023224	eif3d	96	92.105	Seriola_dumerili
ENSG00000100353	EIF3D	100	93.103	ENSSLDG00000006833	eif3d	96	92.105	Seriola_lalandi_dorsalis
ENSG00000100353	EIF3D	89	87.474	ENSSARG00000012488	EIF3D	100	87.474	Sorex_araneus
ENSG00000100353	EIF3D	100	96.748	ENSSPUG00000011683	EIF3D	97	95.841	Sphenodon_punctatus
ENSG00000100353	EIF3D	100	92.683	ENSSPAG00000003591	eif3d	96	91.917	Stegastes_partitus
ENSG00000100353	EIF3D	100	99.453	ENSSSCG00000000141	EIF3D	100	99.453	Sus_scrofa
ENSG00000100353	EIF3D	100	94.444	ENSTGUG00000010728	EIF3D	97	95.472	Taeniopygia_guttata
ENSG00000100353	EIF3D	100	91.870	ENSTRUG00000007886	eif3d	96	90.977	Takifugu_rubripes
ENSG00000100353	EIF3D	100	91.057	ENSTNIG00000011263	eif3d	96	91.485	Tetraodon_nigroviridis
ENSG00000100353	EIF3D	93	99.014	ENSTBEG00000006268	EIF3D	100	99.014	Tupaia_belangeri
ENSG00000100353	EIF3D	100	98.885	ENSTTRG00000006637	EIF3D	100	98.540	Tursiops_truncatus
ENSG00000100353	EIF3D	100	99.257	ENSUAMG00000017485	EIF3D	99	99.081	Ursus_americanus
ENSG00000100353	EIF3D	100	99.257	ENSUMAG00000015827	EIF3D	100	99.088	Ursus_maritimus
ENSG00000100353	EIF3D	79	94.811	ENSVPAG00000000359	-	100	92.361	Vicugna_pacos
ENSG00000100353	EIF3D	100	99.257	ENSVVUG00000023578	EIF3D	100	99.088	Vulpes_vulpes
ENSG00000100353	EIF3D	100	89.338	ENSXETG00000027259	eif3d	96	90.414	Xenopus_tropicalis
ENSG00000100353	EIF3D	100	82.593	ENSXCOG00000011633	eif3d	97	84.023	Xiphophorus_couchianus
ENSG00000100353	EIF3D	100	91.870	ENSXMAG00000000954	eif3d	96	91.729	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001732	formation of cytoplasmic translation initiation complex	-	IEA	Process
GO:0002191	cap-dependent translational initiation	27462815.	IDA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	25849773.	IDA	Function
GO:0003743	translation initiation factor activity	21873635.	IBA	Function
GO:0003743	translation initiation factor activity	17322308.18599441.	IC	Function
GO:0003743	translation initiation factor activity	17581632.25849773.27462815.	IDA	Function
GO:0005515	protein binding	11369516.18599441.20890303.22190034.23623729.24092755.25416956.	IPI	Function
GO:0005829	cytosol	-	TAS	Component
GO:0005852	eukaryotic translation initiation factor 3 complex	21873635.	IBA	Component
GO:0005852	eukaryotic translation initiation factor 3 complex	17322308.17581632.18599441.25849773.27462815.	IDA	Component
GO:0006413	translational initiation	21873635.	IBA	Process
GO:0006413	translational initiation	17322308.18599441.	IC	Process
GO:0006413	translational initiation	17581632.	IDA	Process
GO:0006413	translational initiation	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016282	eukaryotic 43S preinitiation complex	-	IEA	Component
GO:0033290	eukaryotic 48S preinitiation complex	-	IEA	Component
GO:0045727	positive regulation of translation	24092755.	IPI	Process
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	-	IEA	Component
GO:0075522	IRES-dependent viral translational initiation	9573242.	IDA	Process
GO:0075525	viral translational termination-reinitiation	21347434.	IDA	Process
GO:0098808	mRNA cap binding	27462815.	IDA	Function
GO:1902416	positive regulation of mRNA binding	24092755.	IPI	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.