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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24317682Silencing Dicer expression enhances cellular proliferative and invasive capacities in human tongue squamous cell carcinoma.Oncol Rep2014 FebZeng Sdoi: 10.3892/or.2013.2903
26598979Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT) Commonly Exhibits Positivity With Sex Cord Markers FOXL2 and SF-1 but Lacks FOXL2 and DICER1 Mutations.Int J Gynecol Pathol2016 JulCroce Sdoi: 10.1097/PGP.0000000000000240.
21882293Extending the phenotypes associated with DICER1 mutations.Hum Mutat2011 DecFoulkes WDdoi: 10.1002/humu.21600
23625684DICER1 syndrome: a new cancer syndrome.Klin Padiatr2013 MaySchultze-Florey REdoi: 10.1055/s-0033-1337976
22546613In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs.RNA2012 JunGurtan AMdoi: 10.1261/rna.032680.112
21205968DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.JAMA2011 Jan 5Rio Frio Tdoi: 10.1001/jama.2010.1910.
27830327Lack of mutation of DICER1 and FOXL2 genes in microcystic stromal tumor of the ovary.Virchows Arch2017 FebMeurgey Adoi: 10.1007/s00428-016-2038-2
18239938Mucoepidermoid carcinoma of upper aerodigestive tract: clinicopathologic study of 78 cases with immunohistochemical analysis of Dicer expression.Virchows Arch2008 JunChiosea SIdoi: 10.1007/s00428-007-0574-5
26983701The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome.Virchows Arch2016 MayDurieux Edoi: 10.1007/s00428-016-1922-0
19520829Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1.Proc Natl Acad Sci U S A2009 Jun 30Ueda Rdoi: 10.1073/pnas.0811817106
26725326Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression.Oncogene2016 Aug 18Rupaimoole Rdoi: 10.1038/onc.2015.492
28748527The prevalence of DICER1 pathogenic variation in population databases.Int J Cancer2017 Nov 15Kim Jdoi: 10.1002/ijc.30907
27441995Macrocephaly associated with the DICER1 syndrome.Genet Med2017 FebKhan NEdoi: 10.1038/gim.2016.83
28916654Biallelic Dicer1 Loss Mediated by aP2-Cre Drives Angiosarcoma.Cancer Res2017 Nov 15Hanna JAdoi: 10.1158/0008-5472.CAN-17-1262
28620008PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.Clin Cancer Res2017 Jun 15Schultz KAPdoi: 10.1158/1078-0432.CCR-17-0629.
29199004Dicer reprograms stromal fibroblasts to a pro-inflammatory and tumor-promoting phenotype in ovarian cancer.Cancer Lett2018 Feb 28Yang Zdoi: 10.1016/j.canlet.2017.11.026
30181547GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression.Oncogene2019 FebYuan Xdoi: 10.1038/s41388-018-0483-x
19092150Dicer, Drosha, and outcomes in patients with ovarian cancer.N Engl J Med2008 Dec 18Merritt WMdoi: 10.1056/NEJMoa0803785.
26965998Jak-STAT3 pathway triggers DICER1 for proteasomal degradation by ubiquitin ligase complex of CUL4A(DCAF1) to promote colon cancer development.Cancer Lett2016 Jun 1Ren Wdoi: 10.1016/j.canlet.2016.02.055
21761362MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer.Horm Cancer2010 DecCochrane DRdoi: 10.1007/s12672-010-0043-5.
21878538Dicer-mediated upregulation of BCRP confers tamoxifen resistance in human breast cancer cells.Clin Cancer Res2011 Oct 15Selever Jdoi: 10.1158/1078-0432.CCR-11-1403
22716222Down-regulation of the microRNA processing enzyme Dicer is a prognostic factor in human colorectal cancer.Histopathology2012 OctFaggad Adoi: 10.1111/j.1365-2559.2011.04110.x.
21898071Dysregulated expression of dicer and drosha in breast cancer.Pathol Oncol Res2012 AprYan Mdoi: 10.1007/s12253-011-9450-3
22179432Downregulation of Dicer, a component of the microRNA machinery, in bladder cancer.Mol Med Rep2012 MarWu Ddoi: 10.3892/mmr.2011.711
25135428Down-regulation of Dicer and Ago2 is associated with cell proliferation and apoptosis in prostate cancer.Tumour Biol2014 NovBian XJdoi: 10.1007/s13277-014-2462-3
21425145DICER1 expression and outcomes in endometrioid endometrial adenocarcinoma.Cancer2011 Apr 1Zighelboim Idoi: 10.1002/cncr.25665
22446887Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells.Int J Mol Med2012 JunDewi DLdoi: 10.3892/ijmm.2012.945
25115815Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells.Mol Cancer2014 Aug 13Cantini LPdoi: 10.1186/1476-4598-13-190.
261473043'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.PLoS One2015 Jul 6Cho SHdoi: 10.1371/journal.pone.0131125
24065110Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides.Eur J Hum Genet2014 AprSabbaghian Ndoi: 10.1038/ejhg.2013.215
23392577miR-130b is an EMT-related microRNA that targets DICER1 for aggression in endometrial cancer.Med Oncol2013 MarLi BLdoi: 10.1007/s12032-013-0484-0
22407237Clinicopathological and prognostic significance of microRNA-107 and its relationship to DICER1 mRNA expression in gastric cancer.Oncol Rep2012 JunInoue Tdoi: 10.3892/or.2012.1709
27492604Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression.Tumour Biol2016 OctZhu Y-
25656609EIF2C, Dicer, and Drosha are up-regulated along tumor progression and associated with poor prognosis in bladder carcinoma.Tumour Biol2015 JulZhang Zdoi: 10.1007/s13277-015-3158-z
25526195Germline mutations of DICER1 in Chinese women with BRCA1/BRCA2-negative familial breast cancer.Genet Mol Res2014 Dec 18Cao WMdoi: 10.4238/2014.December.18.16.
24287487Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer.Nat Commun2013Yu Zdoi: 10.1038/ncomms3812.
21559780Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer.Tumour Biol2011 AugTorres Adoi: 10.1007/s13277-011-0179-0
24096488Impaired DICER1 function promotes stemness and metastasis in colon cancer.Oncogene2014 Jul 24Iliou MSdoi: 10.1038/onc.2013.398
23441612Identification of microRNAs regulated by isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic colorectal cancer.Nutr Cancer2013Slaby Odoi: 10.1080/01635581.2013.756530.
21029372MicroRNA-107, an oncogene microRNA that regulates tumour invasion and metastasis by targeting DICER1 in gastric cancer.J Cell Mol Med2011 SepLi Xdoi: 10.1111/j.1582-4934.2010.01194.x.
21345667Overexpression of Dicer predicts poor survival in colorectal cancer.Eur J Cancer2011 JunFaber Cdoi: 10.1016/j.ejca.2011.01.006
24817967Dysregulation of microRNA biosynthesis enzyme Dicer plays an important role in gastric cancer progression.Int J Clin Exp Pathol2014 Mar 15Zhang J-
22867905Exploring the endocrine manifestations of DICER1 mutations.Trends Mol Med2012 SepChoong CSdoi: 10.1016/j.molmed.2012.07.003
22821364Loss of Dicer expression is associated with breast cancer progression and recurrence.Breast Cancer Res Treat2012 SepKhoshnaw SMdoi: 10.1007/s10549-012-2169-3
22252463Reduced DICER1 elicits an interferon response in endometrial cancer cells.Mol Cancer Res2012 MarChiappinelli KBdoi: 10.1158/1541-7786.MCR-11-0520
23071822Genetic variations in key microRNA processing genes and risk of head and neck cancer: a case-control study in Chinese population.PLoS One2012Ma Hdoi: 10.1371/journal.pone.0047544
24725360The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer.BMC Cancer2014 Apr 11Avery-Kiejda KAdoi: 10.1186/1471-2407-14-253.
19672267Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype.Br J Cancer2009 Aug 18Grelier Gdoi: 10.1038/sj.bjc.6605193.
18413723A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.Cancer Res2008 Apr 15Ting AHdoi: 10.1158/0008-5472.CAN-07-6405.
24676997Down-regulation of Dicer expression in cervical cancer tissues.Med Oncol2014 MayZhao Hdoi: 10.1007/s12032-014-0937-0
18167183Decreased expression of DICER1 in gastric cancer.Chin Med J (Engl)2007 Dec 5Zheng ZH-
25640338Association between the DICER rs1057035 polymorphism and cancer risk: evidence from a meta-analysis of 1,2675 individuals.Asian Pac J Cancer Prev2015Yu YY-
23851498A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.Oncogene2014 Jun 12Zhang Bdoi: 10.1038/onc.2013.281
26156018High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer.Oncotarget2015 Sep 15Czubak K-
24787017Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer.Cell Death Dis2014 May 1He Ldoi: 10.1038/cddis.2014.127.
25176334DICER1: mutations, microRNAs and mechanisms.Nat Rev Cancer2014 OctFoulkes WDdoi: 10.1038/nrc3802
27036314Tumor progression in DICER1-mutated cystic nephroma-witnessing the genesis of anaplastic sarcoma of the kidney.Hum Pathol2016 JulWu MKdoi: 10.1016/j.humpath.2016.03.002
27260947Dicer expression in estrogen receptor-positive versus triple-negative breast cancer: an antibody comparison.Hum Pathol2016 OctSpoelstra NSdoi: 10.1016/j.humpath.2016.05.014
28911000Dicer regulates non-homologous end joining and is associated with chemosensitivity in colon cancer patients.Carcinogenesis2017 Sep 1Chen Xdoi: 10.1093/carcin/bgx059.
28650464β-catenin downregulates Dicer to promote ovarian cancer metastasis.Oncogene2017 Oct 26To SKYdoi: 10.1038/onc.2017.185
27924483Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods.Methods Mol Biol2017Haga CL-
27682871Role of Dicer as a prognostic predictor for survival in cancer patients: a systematic review with a meta-analysis.Oncotarget2016 Nov 8Shan Wdoi: 10.18632/oncotarget.12183.
30221734Dicer affects cisplatinmediated apoptosis in epithelial ovarian cancer cells.Mol Med Rep2018 NovWang Xdoi: 10.3892/mmr.2018.9452

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1495105083Frame_Shift_DelnovelP1086Lfs*90.46
BLCAchr1495095796Intronnovel0.4
BLCAchr1495113133Missense_MutationnovelL667V0.09Ribonuclease_3
BLCAchr1495124419Missense_Mutationrs746886465R385C0.38
BLCAchr1495103954Missense_MutationNAQ1148E0.65
BLCAchr1495095868SilentNAL1684L0.4
BLCAchr1495095896Missense_MutationnovelY1675F0.32
BLCAchr1495096171SilentnovelL1583L0.13
BLCAchr1495103749Missense_MutationnovelS1216L0.3
BLCAchr1495103993Missense_MutationnovelQ1135E0.25
BLCAchr1495130154Missense_MutationnovelL159F0.14
BLCAchr1495094127Missense_MutationNAD1709N0.46
BLCAchr1495126586Silentrs201842071S299S0.4
BLCAchr1495132662Missense_MutationnovelA54T0.41
BLCAchr1495096362Missense_MutationnovelE1520Q0.17
BLCAchr1495094080Silentrs780782755P1724P0.06
BLCAchr1495096117Missense_MutationnovelK1601N0.27
BLCAchr1495096406Missense_MutationNAS1505C0.3
BLCAchr1495107752Missense_MutationnovelS887C0.28
BLCAchr1495094027Missense_MutationNAN1742S0.37
BLCAchr1495105224Missense_MutationnovelA1039G0.06
BLCAchr1495096325Missense_MutationnovelE1532G0.43
BLCAchr1495090609SilentnovelG1886G0.81
BLCAchr1495113171Missense_MutationnovelR654K0.47Ribonuclease_3
BLCAchr1495093957SilentnovelL1765L0.21
BLCAchr1495096519Missense_MutationnovelI1467M0.27
BRCAchr1495131625Missense_MutationNAQ108E0.09
BRCAchr1495108434Missense_MutationNAV776F0.22
BRCAchr1495112204Missense_MutationNAA695V0.4Ribonuclease_3
BRCAchr1495131551SilentNAS132S0.35
BRCAchr14950902383'UTRnovel0.36
BRCAchr14950904233'UTRnovel0.37
BRCAchr1495094012Missense_MutationNAS1747L0.22
BRCAchr1495115802Missense_MutationNAS591C0.31
BRCAchr1495105687SilentNAQ1028Q0.19
BRCAchr1495115796Missense_Mutationrs752424727S593L0.25
BRCAchr14950897313'UTRnovel0.45
BRCAchr14950867373'UTRnovel0.14
BRCAchr1495096490Missense_MutationnovelS1477C0.17
BRCAchr1495105734Missense_MutationnovelP1013T0.1
BRCAchr1495095677Intronnovel0.42
BRCAchr1495117641Missense_MutationNAE497A0.15
BRCAchr1495103378Missense_MutationNAE1340Q0.21
BRCAchr1495096391Missense_MutationNAC1510Y0.43
CESCchr1495108472Missense_MutationNAR763K0.16
CESCchr1495111455Splice_Regionrs191755360G706G0.63
CESCchr14950866093'UTRnovel0.33
CESCchr1495130191Missense_MutationNAV147A0.2
CESCchr1495091302Missense_Mutationrs775912475D1810N0.34
CESCchr1495094110Nonsense_MutationnovelY1714*0.08
CESCchr1495094112Frame_Shift_InsnovelY1714Sfs*50.08
CESCchr1495095954Frame_Shift_InsnovelD1656Wfs*50.1
CESCchr1495132567SilentnovelI85I0.32
CESCchr14950889123'UTRnovel0.42
CESCchr1495090600Frame_Shift_DelnovelK1889Nfs*390.36
CESCchr1495103562SilentnovelE1278E0.37
CESCchr1495111393Missense_MutationnovelD727G0.45
CESCchr1495115819Splice_RegionnovelI585I0.1
CESCchr1495132653Missense_MutationnovelD57N0.12
CESCchr1495124243Silentrs776143079C443C0.24
CESCchr1495095939Missense_MutationnovelH1661Y0.29
CESCchr1495103462SilentnovelL1312L0.32
CESCchr1495103738Nonsense_MutationNAQ1220*0.09
CESCchr1495113127SilentnovelL669L0.44
CESCchr1495090531SilentNAL1912L0.41
CESCchr1495108444SilentNAV772V0.26
CHOLchr1495103365Missense_MutationNAS1344L0.42
CHOLchr1495103366Missense_MutationnovelS1344T0.44
CHOLchr14950869693'UTRnovel0.5
CHOLchr14950882103'UTRnovel0.1
COADchr1495090601Missense_MutationNAK1889T0.38
COADchr1495107680Missense_MutationNAS911I0.39
COADchr1495096462Frame_Shift_DelNAK1486Nfs*40.23
COADchr1495096145Missense_MutationNAP1592L0.17
COADchr1495091302Missense_Mutationrs775912475D1810N0.74
COADchr1495103495Missense_MutationnovelL1301M0.32
COADchr1495111344Silentrs753276132T743T0.31
COADchr1495106197Missense_MutationNAR944Q0.25
COADchr1495108337Missense_MutationnovelK808T0.07
COADchr1495116635Nonsense_MutationnovelE524*0.34
COADchr14951334915'UTRnovel0.24
COADchr1495105180Missense_MutationnovelL1054F0.27
COADchr14950904543'UTRrs7806754120.31
COADchr1495103365Missense_MutationNAS1344L0.33
COADchr1495129554Nonsense_MutationNAE218*0.36
COADchr1495124356Nonsense_MutationnovelQ406*0.15
COADchr1495105780SilentnovelL997L0.12
COADchr1495106177Missense_MutationnovelY951H0.16
COADchr1495111454Missense_MutationnovelE707K0.14Ribonuclease_3
COADchr1495124273Missense_MutationnovelN433K0.15
COADchr1495090613Missense_MutationnovelV1885A0.05
COADchr1495108391Missense_Mutationrs762784970R790Q0.35
COADchr1495096241Missense_MutationNAA1560V0.09
COADchr1495094139Missense_MutationNAE1705Q0.56
COADchr1495103438Missense_MutationnovelD1320N0.11
COADchr1495096502Frame_Shift_InsNAS1473Ffs*40.2
COADchr1495090590Missense_MutationnovelV1893F0.41
COADchr1495095919Missense_MutationNAE1667D0.11
COADchr1495106197Missense_MutationNAR944Q0.3
COADchr1495133325Missense_MutationNAR45K0.17
COADchr1495091288Silentrs759875628S1814S0.36
COADchr1495108391Missense_Mutationrs762784970R790Q0.38
COADchr1495124590Nonsense_MutationNAE328*0.31
COADchr1495103626Missense_MutationnovelV1257A0.09
COADchr1495106095Missense_MutationnovelL978R0.37
COADchr1495112234Missense_MutationnovelS685N0.08Ribonuclease_3
COADchr1495096071Missense_MutationNAL1617I0.2
COADchr1495106205SilentnovelQ941Q0.21
COADchr1495095928Silentrs781268313S1664S0.05
COADchr1495113158SilentnovelL658L0.41
ESCAchr1495103932Missense_Mutationrs766598800T1155M0.31
ESCAchr1495103412SilentnovelT1328T0.26
ESCAchr14950900053'UTRnovel0.46
ESCAchr14950865553'UTRnovel0.48
GBMchr1495091056Missense_MutationNAE1861K0.26
GBMchr1495131556Missense_MutationnovelA131P0.09
GBMchr1495096359Missense_MutationnovelD1521Y0.73
GBMchr1495096222Silentrs372837448L1566L0.44
GBMchr1495095715Intronnovel0.09
GBMchr1495103921Missense_Mutationrs145693584E1159K0.27
GBMchr1495108092Missense_MutationnovelI813S0.2
GBMchr1495108094Splice_SitenovelX813_splice0.15
GBMchr1495116695Missense_MutationnovelV504L0.32
GBMchr1495130168Missense_Mutationrs745802492A155T0.48
GBMchr1495091292Missense_MutationnovelE1813G0.96
GBMchr1495107693Missense_MutationnovelI907L0.25
GBMchr1495094139Missense_MutationNAE1705Q0.49
GBMchr1495105165In_Frame_DelnovelC1053_L1058del0.23
HNSCchr1495094066Missense_MutationnovelP1729Q0.06
HNSCchr1495091215Missense_MutationNAR1839W0.05
HNSCchr1495124501SilentnovelA357A0.22
HNSCchr1495129555Missense_MutationnovelE217D0.32
HNSCchr1495096070Missense_MutationnovelL1617H0.4
HNSCchr1495126614Missense_MutationnovelS290L0.4
HNSCchr1495107673Missense_MutationnovelK913N0.32
HNSCchr1495105734Missense_MutationnovelP1013S0.11
HNSCchr1495130193Splice_SitenovelX147_splice0.19
HNSCchr1495103700Silentrs767516330S1232S0.32
HNSCchr1495096564Frame_Shift_DelnovelF1452Lfs*20.15
HNSCchr1495115774Missense_MutationnovelD600E0.34
HNSCchr1495116581Missense_MutationnovelE542K0.1
HNSCchr1495105169SilentnovelI1057I0.14
HNSCchr1495117750Missense_Mutationrs141163928I461V0.15
HNSCchr1495108362SilentnovelR800R0.28
HNSCchr1495129560Missense_MutationnovelP216S0.74
HNSCchr1495095939Missense_MutationnovelH1661Y0.14
KICHchr1495113224Splice_RegionNAR636R0.56
KIRCchr1495091213SilentNAR1839R0.27
KIRCchr1495099868Nonsense_MutationnovelI1373Rfs*30.16
KIRPchr1495124263Missense_MutationnovelP437A0.57
KIRPchr1495090543SilentNAA1908A0.36
LAMLchr1495091280Missense_MutationnovelG1817D0.04
LGGchr1495094127Missense_MutationNAD1709N0.37
LGGchr1495111455Splice_Regionrs191755360G706G0.38
LIHCchr1495124505Missense_MutationnovelH356L0.29
LIHCchr1495108382Missense_Mutationrs527568726Y793C0.3
LIHCchr1495090644Missense_Mutationrs745601023D1875N0.36
LIHCchr1495111317Splice_RegionnovelA752A0.13
LIHCchr1495094157Splice_SiteNAX1699_splice0.37
LIHCchr1495091108Missense_MutationNAE1843D0.21
LUADchr1495105138Missense_MutationNAE1068K0.14
LUADchr1495117689Missense_MutationNAG481V0.43
LUADchr1495096222SilentnovelL1566L0.08
LUADchr1495104038Missense_MutationnovelN1120H0.22
LUADchr1495126604SilentnovelR293R0.04
LUADchr1495103818Missense_MutationNAN1193S0.19
LUADchr1495130121SilentNAN170N0.17
LUADchr1495096406Missense_MutationNAS1505F0.32
LUADchr1495107953SilentnovelR859R0.07
LUADchr1495091085Missense_MutationnovelR1851L0.28
LUADchr1495124663Silentrs773509809L303L0.15
LUADchr1495117746Missense_MutationnovelK462R0.12
LUADchr1495105683Missense_MutationnovelK1030E0.27
LUADchr1495124642Missense_MutationnovelL310F0.09
LUADchr1495103818Missense_MutationNAN1193S0.48
LUADchr1495115716Missense_MutationNAD620Y0.23
LUADchr1495107651Missense_MutationNAV921F0.11
LUADchr1495096251Missense_MutationNAK1557E0.28
LUADchr14950904503'UTRrs7576823300.4
LUADchr14950873013'UTRnovel1
LUADchr1495090660SilentnovelP1869P0.33
LUSCchr1495105099Missense_MutationnovelG1081R0.66
LUSCchr1495094115Missense_MutationnovelD1713Y0.42
LUSCchr1495095764Intronnovel0.13
LUSCchr1495090659Missense_MutationNAA1870S0.52
LUSCchr1495099916Missense_MutationnovelY1357C0.11
LUSCchr1495124216Nonsense_MutationnovelY452*0.33
LUSCchr1495096372Missense_MutationNAK1516N0.32
LUSCchr1495091344Missense_MutationNAE1796K0.07
LUSCchr1495107940Missense_MutationnovelA864T0.25
LUSCchr1495096182Missense_MutationnovelQ1580K0.39
LUSCchr1495103789Missense_MutationNAN1203Y0.34
LUSCchr1495091312Missense_MutationnovelK1806N0.14
LUSCchr1495094040Frame_Shift_DelnovelD1734Pfs*260.43
LUSCchr1495091086Missense_MutationNAR1851C0.19
LUSCchr1495108421Missense_MutationNAP780L0.37
LUSCchr1495107689Missense_MutationnovelG908V0.16
LUSCchr1495116534Missense_MutationNAI557M0.14
LUSCchr1495124470Missense_MutationNAL368V0.12
LUSCchr1495115738SilentnovelP612P0.39
LUSCchr1495096644Missense_MutationnovelS1426C0.26
OVchr1495096210Nonsense_MutationnovelY1570*0.08
OVchr1495103691SilentnovelC1235C0.21
OVchr1495105689Nonsense_MutationnovelQ1028*0.16
OVchr1495111437SilentnovelL712L0.89
OVchr1495095658Intronnovel0.31
OVchr1495133389Missense_Mutationrs754439528M24V0.2
OVchr1495105073Missense_MutationnovelF1089L0.13
OVchr1495108343Missense_Mutationrs749834289T806M0.19
OVchr1495108084Frame_Shift_InsnovelF816Ifs*180.04
OVchr1495126659Missense_MutationNAE275A0.33
OVchr1495116514Missense_Mutationrs201298288A564V0.48
PAADchr1495106152Missense_MutationnovelK959I0.05
PAADchr14950903843'UTRnovel0.22
PAADchr1495093976Missense_Mutationrs144259142K1759R0.19
PAADchr1495099883Missense_MutationnovelR1368H0.2
PAADchr1495103650Missense_MutationnovelK1249T0.18
PAADchr1495105102Missense_MutationNAV1080M0.05
PAADchr1495106197Missense_MutationNAR944Q0.17
PAADchr1495115738SilentnovelP612P0.19
PAADchr1495124590Nonsense_MutationNAE328*0.04
PAADchr1495130168Missense_Mutationrs745802492A155T0.09
PAADchr1495124496Missense_MutationnovelC359Y0.2
PRADchr1495095825Missense_MutationnovelD1699N0.1
PRADchr1495105103Silentrs764827361G1079G0.36
PRADchr1495105190SilentnovelK1050K0.4
READchr1495094122Silentrs769974404A1710A0.17
READchr1495105763Missense_MutationNAR1003Q0.28
READchr1495115688Missense_Mutationrs750410087T629M0.27
READchr1495106152Missense_MutationnovelK959T0.06
READchr1495095687Intronnovel0.35
READchr1495106197Missense_MutationNAR944Q0.42
READchr1495111344Silentrs753276132T743T0.4
READchr1495113105Missense_MutationnovelR676Q0.09Ribonuclease_3
READchr1495124428Missense_MutationNAE382K0.1
SARCchr1495117701Missense_MutationNAN477S0.44
SARCchr1495096242Missense_MutationnovelA1560T0.31
SARCchr1495094127Missense_MutationNAD1709N0.9
SKCMchr1495090661Missense_MutationnovelP1869L0.46
SKCMchr1495090662Missense_MutationnovelP1869S0.45
SKCMchr14950904323'UTRrs1919963640.38
SKCMchr1495116680Nonsense_MutationNAR509*0.26
SKCMchr1495111363Missense_MutationNAP737L0.26
SKCMchr1495104057SilentNAS1113S0.26
SKCMchr1495094088Missense_MutationnovelE1722K0.19
SKCMchr1495106183Missense_MutationnovelD949Y0.06
SKCMchr1495099914Missense_MutationNAR1358C0.3
SKCMchr1495106198Nonsense_Mutationrs137852978R944*0.38
SKCMchr1495124546Missense_MutationNAR342S0.44
SKCMchr1495090562Missense_MutationNAS1902F0.25
SKCMchr1495111370Missense_MutationnovelS735G0.34
SKCMchr1495105162Missense_MutationNAR1060C0.07
SKCMchr1495111379Nonsense_MutationnovelE732*0.27
SKCMchr1495096271Missense_MutationNAT1550I0.23
SKCMchr1495096055Missense_MutationnovelA1622D0.44
SKCMchr1495108047Missense_MutationNAS828F0.7
SKCMchr1495131572In_Frame_DelnovelY124_S125del0.33
SKCMchr1495094134SilentnovelF1706F0.14
SKCMchr1495116453Splice_RegionNAK584K0.43
SKCMchr1495094069Missense_Mutationrs762801582S1728F0.33
SKCMchr1495103742SilentnovelS1218S0.35
SKCMchr1495113202Missense_MutationnovelD644Y0.33Ribonuclease_3
SKCMchr1495130072Nonsense_Mutationrs763801533R187*0.24
SKCMchr1495094082Missense_MutationnovelP1724S0.54
SKCMchr1495103705Missense_MutationNAP1231S0.2
SKCMchr1495126738Nonsense_MutationNAQ249*0.12
SKCMchr1495105097SilentnovelG1081G0.41
SKCMchr1495107616SilentNAI932I0.09
SKCMchr1495103971Missense_MutationNAS1142F0.39
SKCMchr1495094145Missense_MutationNAR1703S0.2
SKCMchr1495117691SilentNAT480T0.11
SKCMchr1495091302Missense_Mutationrs775912475D1810N0.71
SKCMchr1495108047Missense_MutationNAS828F0.16
SKCMchr1495124269Missense_MutationNAP435S0.24
SKCMchr1495103365Missense_MutationNAS1344L0.21
SKCMchr1495105153Missense_MutationNAC1063G0.38
SKCMchr1495116537SilentnovelP556P0.25
SKCMchr1495126667Missense_MutationNAM272I0.36
SKCMchr1495094012Missense_MutationNAS1747L0.38
SKCMchr1495116680Nonsense_MutationNAR509*0.19
SKCMchr1495116680Nonsense_MutationNAR509*0.32
SKCMchr1495113111Missense_MutationNAP674L0.22Ribonuclease_3
STADchr1495096041Missense_MutationNAA1627T0.11
STADchr1495103493SilentnovelL1301L0.15
STADchr1495103372Missense_Mutationrs776854466R1342C0.19
STADchr1495103408Missense_MutationnovelY1330H0.16
STADchr1495115700Missense_MutationnovelV625G0.07
STADchr1495124648Silentrs142397473A308A0.05
STADchr14951334775'UTRnovel0.21
STADchr14950904583'UTRnovel0.42
STADchr1495124315SilentnovelD419D0.34
STADchr1495096128Missense_Mutationrs757177980D1598N0.12
STADchr1495124243Silentrs776143079C443C0.3
STADchr1495091254Missense_MutationNAS1826P0.04
STADchr1495117662Missense_MutationNAR490H0.22
STADchr1495133405SilentNAT18T0.35
STADchr1495103778SilentnovelK1206K0.08
STADchr1495091329Missense_MutationNAD1801N0.3
STADchr1495124647Missense_MutationNAV309I0.21
STADchr1495108091Splice_RegionNAI813I0.25
STADchr1495124595Missense_MutationNAV326A0.27
STADchr1495103382Silentrs143454689A1338A0.15
TGCTchr1495096629Missense_MutationnovelA1431S0.16
THCAchr1495091292Missense_MutationnovelE1813G0.34
THCAchr1495132576Frame_Shift_DelnovelS82Ifs*450.26
THCAchr1495091302Missense_MutationNAD1810H0.35
THCAchr1495124440Frame_Shift_DelnovelK376Nfs*110.35
THCAchr1495090549Missense_MutationNAR1906S0.36
THYMchr14950863143'UTRnovel0.67
UCECchr1495108464Missense_MutationnovelQ766K0.24
UCECchr1495096649Missense_MutationNAE1424G0.04
UCECchr1495096594Missense_MutationNAF1442L0.37
UCECchr1495096123SilentNAR1599R0.34
UCECchr1495096474Missense_MutationNAK1482N0.31
UCECchr1495103661SilentnovelG1245G0.34
UCECchr1495111339Missense_MutationnovelR745Q0.16
UCECchr1495115716Missense_MutationnovelD620N0.15
UCECchr1495124398Nonsense_MutationnovelR392*0.33
UCECchr1495091302Missense_Mutationrs775912475D1810N0.31
UCECchr1495091323Missense_MutationNAE1803K0.36
UCECchr1495103813Missense_MutationNAD1195N0.38
UCECchr1495106197Missense_MutationNAR944Q0.35
UCECchr1495116526Missense_MutationNAY560C0.23
UCECchr1495124296Nonsense_MutationNAE426*0.17
UCECchr1495096096Missense_MutationNAE1608D0.16
UCECchr1495103512Missense_MutationnovelG1295V0.39
UCECchr1495103700Silentrs767516330S1232S0.1
UCECchr1495107735Missense_MutationnovelD893N0.38
UCECchr1495108331Missense_MutationnovelI810T0.44
UCECchr1495115769Missense_MutationnovelD602G0.06
UCECchr1495095697Intronnovel0.15
UCECchr1495091291Missense_MutationNAE1813D0.32
UCECchr1495091305Missense_MutationNAG1809R0.43
UCECchr1495111349Missense_MutationnovelS742T0.4
UCECchr1495132610Missense_MutationnovelT71I0.33
UCECchr1495096503Frame_Shift_DelnovelS1473Qfs*170.24
UCECchr1495094020SilentNAI1744I0.39
UCECchr1495094139Missense_MutationNAE1705K0.38
UCECchr1495124550Missense_MutationNAH341P0.12
UCECchr14950880483'UTRnovel0.71
UCECchr1495096075Missense_MutationnovelK1615N0.39
UCECchr1495130192Missense_MutationnovelV147I0.35
UCECchr1495132621SilentnovelG67G0.41
UCECchr1495104082Missense_MutationnovelK1105T0.26
UCECchr14950872533'UTRnovel0.29
UCECchr14950888093'UTRnovel0.23
UCECchr1495090574Missense_MutationnovelR1898M0.27
UCECchr1495124297SilentnovelE425E0.5
UCECchr14950882283'UTRnovel0.33
UCECchr1495091074Nonsense_MutationnovelR1855*0.27
UCECchr1495112228Missense_MutationnovelV687A0.37Ribonuclease_3
UCECchr1495126643Missense_MutationnovelF280L0.3
UCECchr1495095770Intronnovel0.5
UCECchr1495103704Missense_MutationnovelP1231L0.05
UCECchr1495091267Missense_MutationNAM1821I0.42
UCECchr1495094127Missense_MutationNAD1709N0.4
UCECchr1495096461Frame_Shift_InsnovelS1487Ifs*50.2
UCECchr1495113138Missense_MutationNAS665L0.08Ribonuclease_3
UCECchr1495126619SilentNAV288V0.38
UCECchr1495094138Missense_MutationNAE1705A0.26
UCECchr1495095971Missense_Mutationrs760439905F1650C0.17
UCECchr1495117662Missense_MutationNAR490H0.24
UCECchr1495131526Nonsense_MutationnovelE141*0.04
UCECchr1495115717Silentrs747735065D619D0.31
UCECchr1495103347Frame_Shift_DelnovelK1350Rfs*290.23
UCECchr1495103575Missense_MutationNAR1274M0.33
UCECchr1495107916Missense_Mutationrs149242330A872T0.42
UCECchr1495094139Missense_MutationNAE1705K0.48
UCECchr14950898473'UTRnovel0.44
UCECchr1495103365Missense_MutationNAS1344L0.61
UCECchr14950881693'UTRnovel0.33
UCECchr1495103921Missense_Mutationrs145693584E1159K0.46
UCECchr1495129525Missense_MutationnovelE227D0.37
UCECchr1495124540Missense_MutationnovelF344L0.64
UCECchr14950899453'UTRnovel0.33
UCECchr1495091354Silentrs17191079S1792S0.33
UCECchr1495103705Missense_MutationNAP1231S0.25
UCECchr1495117626Missense_MutationnovelE502G0.22
UCECchr14950887783'UTRrs5313157370.31
UCECchr1495095868SilentNAL1684L0.27
UCECchr1495107903Missense_MutationnovelY876C0.45
UCECchr1495129518Missense_MutationnovelL230I0.26
UCECchr1495132535Missense_Mutationrs770567567T96M0.3
UCECchr1495133330SilentnovelT43T0.29
UCECchr1495137935Intronnovel0.44
UCECchr1495094139Missense_MutationNAE1705K0.35
UCECchr1495099830Missense_MutationnovelV1386I0.29
UCECchr14950900193'UTRnovel0.5
UCECchr14950889933'UTRnovel0.44
UCECchr1495091358Missense_MutationnovelR1791I0.43
UCECchr1495105763Missense_MutationNAR1003Q0.53
UCECchr1495107987Missense_MutationnovelR848I0.14
UCECchr1495113165Missense_Mutationrs766707302R656Q0.66Ribonuclease_3
UCECchr1495129525Missense_MutationnovelE227D0.35
UCECchr1495130069Nonsense_MutationnovelE188*0.11
UCECchr1495113196Missense_MutationNAF646L0.3Ribonuclease_3
UCECchr1495113093Missense_MutationNAV680A0.33Ribonuclease_3
UCECchr1495094127Missense_MutationNAD1709N0.45
UCECchr1495106218Missense_MutationNAR937H0.45
UCECchr14950904943'UTRrs7746118490.14
UCECchr14950883503'UTRnovel0.48
UCECchr1495124542Missense_MutationnovelF344I0.5
UCECchr1495115742Frame_Shift_DelnovelF611Sfs*60.33
UCECchr1495132598Missense_MutationnovelV75A0.33
UCECchr1495091302Missense_MutationNAD1810Y0.5
UCECchr1495099856Frame_Shift_DelNAP1377Lfs*20.39
UCECchr1495103365Missense_MutationNAS1344L0.42
UCECchr1495094145Missense_MutationNAR1703C0.42
UCECchr1495113101SilentNAA677A0.05
UCECchr14950888773'UTRnovel0.51
UCECchr1495096464Missense_MutationnovelK1486Q0.56
UCECchr1495126587Missense_Mutationrs755944755S299L0.15
UCECchr1495131576Missense_MutationnovelY124C0.19
UCECchr1495091301Missense_MutationNAD1810A0.42
UCECchr1495116589Frame_Shift_DelNAL539Cfs*230.5
UCECchr1495107891Missense_MutationnovelP880L0.29
UCECchr1495106197Missense_MutationNAR944Q0.25
UCECchr1495116628Missense_MutationnovelV526A0.37
UCECchr1495124290Missense_MutationnovelE428Q0.22
UCECchr1495106197Missense_MutationNAR944Q0.33
UCECchr1495133453Missense_MutationnovelK2N0.4
UCECchr14950881423'UTRnovel0.17
UCECchr14950897333'UTRnovel0.6
UCECchr1495112226Nonsense_MutationNAR688*0.31Ribonuclease_3
UCECchr1495107968Missense_MutationNAF854L0.33
UCECchr1495132639SilentnovelI61I0.07
UCECchr1495091292Missense_MutationnovelE1813G0.44
UCECchr1495094061Frame_Shift_DelnovelV1731Sfs*20.49
UCECchr1495093957SilentnovelL1765L0.31
UCECchr1495111455Splice_Regionrs191755360G706G0.16
UCECchr1495107689Missense_MutationnovelG908D0.14
UCECchr14950873033'UTRnovel0.34
UCECchr1495093905Nonsense_MutationnovelQ1783*0.09
UCECchr1495106050Missense_MutationNAT993I0.26
UCECchr1495111443SilentNAD710D0.34
UCECchr1495105688Missense_MutationnovelQ1028L0.1
UCECchr1495095824Splice_SitenovelX1699_splice0.52
UCECchr1495108470Missense_MutationnovelP764S0.27
UCECchr1495096402Nonsense_MutationnovelW1506*0.09
UCECchr1495099876SilentnovelV1370V0.36
UCECchr1495090589Missense_MutationNAV1893A0.47
UCECchr1495099864SilentnovelF1374F0.36
UCECchr1495133365Missense_MutationNAW32R0.21
UCECchr1495096409Missense_MutationNAS1504N0.45
UCECchr1495124361Missense_MutationNAR404I0.21
UCECchr1495099849In_Frame_InsnovelN1379delinsKQII0.04
UCECchr1495106149Missense_MutationNAF960C0.26
UCECchr1495129540Missense_MutationNAK222N0.27
UCECchr1495091292Missense_MutationNAE1813A0.57
UCECchr1495103433SilentnovelS1321S0.07
UCECchr1495104108Silentrs761973752F1096F0.34
UCECchr1495095839Missense_MutationnovelY1694C0.38
UCECchr1495096113Missense_MutationnovelL1603M0.22
UCECchr1495099829Missense_MutationnovelV1386A0.2
UCECchr1495103456Missense_MutationnovelR1314W0.23
UCECchr1495115704Nonsense_Mutationrs754818927R624*0.41
UCECchr1495126587Missense_Mutationrs755944755S299L0.41
UCECchr1495131541Nonsense_MutationnovelE136*0.2
UCECchr1495124440Missense_MutationNAI378F0.24
UCECchr1495129472Missense_MutationNAR245K0.16
UCECchr1495133331Missense_Mutationrs367797765T43M0.21
UCECchr1495103347Frame_Shift_DelnovelK1350Rfs*290.44
UCECchr1495091289Missense_MutationnovelS1814L0.23
UCECchr1495095960Missense_MutationnovelD1654Y0.32
UCECchr1495096688Missense_MutationnovelG1411D0.4
UCECchr1495103371Missense_Mutationrs767166092R1342H0.1
UCSchr1495091301Missense_MutationNAD1810V0.48
UCSchr1495094127Missense_MutationNAD1709N0.4

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BRCADEL0.25561.4717e-06
CESCDEL0.1390.00086239
CHOLDEL0.55560.00040262
COADDEL0.29050.050084
GBMDEL0.2535.7274e-07
HNSCDEL0.10540.0057325
KIRCDEL0.38070.0074281
KIRPDEL0.16320.085174
LIHCDEL0.32168.4799e-08
LUADDEL0.20930.0018747
MESODEL0.41380.088547
PAADDEL0.06520.11332
READDEL0.37580.189
SKCMDEL0.28610.10277

Survival Analysis
CancerP-value Q-value
KIRC0.0031

Kaplan-Meier Survival Analysis

ACC0.0031

Kaplan-Meier Survival Analysis

LUSC0.043

Kaplan-Meier Survival Analysis

ESCA0.029

Kaplan-Meier Survival Analysis

KIRP0.049

Kaplan-Meier Survival Analysis

PAAD0.03

Kaplan-Meier Survival Analysis

OV0.044

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000100697 (Gene tree)
Gene ID
23405
Gene Symbol
DICER1
Alias
Dicer|KIAA0928|K12H4.8-LIKE|HERNA|MNG1
Full Name
dicer 1, ribonuclease III
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
71,783 bases
Position
chr14:95,086,228-95,158,010
Accession
17098
RBP type
canonical RBP
Summary
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000451041Ribonuclease_3PF00636.263e-7012
ENSP00000451041Ribonuclease_3PF00636.263e-7022
ENSP00000343745Ribonuclease_3PF00636.263.9e-6912
ENSP00000343745Ribonuclease_3PF00636.263.9e-6922
ENSP00000376783Ribonuclease_3PF00636.263.9e-6912
ENSP00000376783Ribonuclease_3PF00636.263.9e-6922
ENSP00000435681Ribonuclease_3PF00636.263.9e-6912
ENSP00000435681Ribonuclease_3PF00636.263.9e-6922
ENSP00000437256Ribonuclease_3PF00636.263.9e-6912
ENSP00000437256Ribonuclease_3PF00636.263.9e-6922
ENSP00000444719Ribonuclease_3PF00636.261.4e-6112
ENSP00000444719Ribonuclease_3PF00636.261.4e-6122
ENSP00000452556Ribonuclease_3PF00636.262.6e-3711
ENSP00000444719PAZPF02170.223.9e-3911
ENSP00000343745PAZPF02170.224.8e-3911
ENSP00000376783PAZPF02170.224.8e-3911
ENSP00000435681PAZPF02170.224.8e-3911
ENSP00000437256PAZPF02170.224.8e-3911
ENSP00000451041Ribonucleas_3_3PF14622.61.6e-2511
ENSP00000343745Ribonucleas_3_3PF14622.63.5e-2411
ENSP00000376783Ribonucleas_3_3PF14622.63.5e-2411
ENSP00000435681Ribonucleas_3_3PF14622.63.5e-2411
ENSP00000437256Ribonucleas_3_3PF14622.63.5e-2411
ENSP00000444719Ribonucleas_3_3PF14622.64.1e-1911
ENSP00000444719ResIIIPF04851.153.5e-1111
ENSP00000343745ResIIIPF04851.153.8e-1111
ENSP00000376783ResIIIPF04851.153.8e-1111
ENSP00000435681ResIIIPF04851.153.8e-1111
ENSP00000437256ResIIIPF04851.153.8e-1111
ENSP00000444719DEADPF00270.295.5e-1111
ENSP00000343745DEADPF00270.295.9e-1111
ENSP00000376783DEADPF00270.295.9e-1111
ENSP00000435681DEADPF00270.295.9e-1111
ENSP00000437256DEADPF00270.295.9e-1111
ENSP00000343745Dicer_dimerPF03368.149.6e-2411
ENSP00000376783Dicer_dimerPF03368.149.6e-2411
ENSP00000435681Dicer_dimerPF03368.149.6e-2411
ENSP00000437256Dicer_dimerPF03368.149.6e-2411
ENSP00000444719Dicer_dimerPF03368.141.1e-2311
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
18635957The XS domain of a plant specific SGS3 protein adopts a unique RNA recognition motif (RRM) fold.Cell Cycle2008 Jul 15Zhang D-
21080422Structures of the first and second double-stranded RNA-binding domains of human TAR RNA-binding protein.Protein Sci2011 JanYamashita Sdoi: 10.1002/pro.543.
24954387'Black sheep' that don't leave the double-stranded RNA-binding domain fold.Trends Biochem Sci2014 JulGleghorn MLdoi: 10.1016/j.tibs.2014.05.003
23550157RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators.Proc Natl Acad Sci U S A2013 Apr 16Redfern ADdoi: 10.1073/pnas.1301620110
20687832Role of small RNAs in host-microbe interactions.Annu Rev Phytopathol2010Katiyar-Agarwal Sdoi: 10.1146/annurev-phyto-073009-114457.
23776147Processing of virus-derived cytoplasmic primary-microRNAs.Wiley Interdiscip Rev RNA2013 Jul-AugShapiro JSdoi: 10.1002/wrna.1169
19372810RNA interference and HIV-1: hits and misses.Curr Opin HIV AIDS2006 MayBennasser Ydoi: 10.1097/01.COH.0000221593.49412.56.
23207479Isolation and characterization of homologous TRBP cDNA for RNA interference in Penaeus monodon.Fish Shellfish Immunol2013 FebYang Ldoi: 10.1016/j.fsi.2012.11.022
23872535The integrative expression and co-expression analysis of the AGO gene family in rice.Gene2013 Oct 10Yang Ydoi: 10.1016/j.gene.2013.07.002
27231846Artificial small RNA for sequence specific cleavage of target RNA through RNase III endonuclease Dicer.Oncotarget2016 Aug 23Xu Wdoi: 10.18632/oncotarget.9582.
16424907The role of PACT in the RNA silencing pathway.EMBO J2006 Feb 8Lee Y-
15973356TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing.Nature2005 Aug 4Chendrimada TP-
15918770Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein.PLoS Biol2005 JulForstemann K-
19811537Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efficacy.FEBS J2009 NovKini HKdoi: 10.1111/j.1742-4658.2009.07364.x
19219043A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.Nat Genet2009 MarMelo SAdoi: 10.1038/ng.317
22145045Widespread regulation of miRNA biogenesis at the Dicer step by the cold-inducible RNA-binding protein, RBM3.PLoS One2011Pilotte Jdoi: 10.1371/journal.pone.0028446
21553022Lin-28 reactivation is required for let-7 repression and proliferation in human small cell lung cancer cells.Mol Cell Biochem2011 SepPan Ldoi: 10.1007/s11010-011-0862-x
20932845Substrate-specific kinetics of Dicer-catalyzed RNA processing.J Mol Biol2010 Dec 3Chakravarthy Sdoi: 10.1016/j.jmb.2010.09.030
25544363Regulatory networks between neurotrophins and miRNAs in brain diseases and cancers.Acta Pharmacol Sin2015 FebShi Jdoi: 10.1038/aps.2014.135
23690119Microsatellite instability and TARBP2 mutation study in upper urinary tract urothelial carcinoma.Am J Clin Pathol2013 JunBai Sdoi: 10.1309/AJCPBSLP8XHSWLOW.
23661684Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing.Nucleic Acids Res2013 JulLee HYdoi: 10.1093/nar/gkt361
23531496Multiple sensors ensure guide strand selection in human RNAi pathways.RNA2013 MayNoland CLdoi: 10.1261/rna.037424.112
16887810HIV-1 TAR RNA subverts RNA interference in transfected cells through sequestration of TAR RNA-binding protein, TRBP.J Biol Chem2006 Sep 22Bennasser Y-
19458189Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies.Mol Biol Cell2009 JulPare JMdoi: 10.1091/mbc.E09-01-0082
19106622The NFAR's (nuclear factors associated with dsRNA): evolutionarily conserved members of the dsRNA binding protein family.RNA Biol2009 Jan-MarBarber GN-
17452327Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA.J Biol Chem2007 Jun 15Kok KH-
25467938Double-stranded RNA in the biological control of grain aphid (Sitobion avenae F.).Funct Integr Genomics2015 MarWang Ddoi: 10.1007/s10142-014-0424-x
16809288Sequestration and protection of double-stranded RNA by the betanodavirus b2 protein.J Virol2006 JulFenner BJ-
19820710Structural insights into RNA processing by the human RISC-loading complex.Nat Struct Mol Biol2009 NovWang HWdoi: 10.1038/nsmb.1673
19422693Characterization of the TRBP domain required for dicer interaction and function in RNA interference.BMC Mol Biol2009 May 7Daniels SMdoi: 10.1186/1471-2199-10-38.
19112503In C. elegans, high levels of dsRNA allow RNAi in the absence of RDE-4.PLoS One2008Habig JWdoi: 10.1371/journal.pone.0004052
23006623TRBP alters human precursor microRNA processing in vitro.RNA2012 NovLee HYdoi: 10.1261/rna.035501.112
18799732Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1.Proc Natl Acad Sci U S A2008 Sep 23Qu Fdoi: 10.1073/pnas.0805760105
18551175SINE RNA induces severe developmental defects in Arabidopsis thaliana and interacts with HYL1 (DRB1), a key member of the DCL1 complex.PLoS Genet2008 Jun 13Pouch-Pelissier MNdoi: 10.1371/journal.pgen.1000096.
17928574Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes.RNA2007 DecLiu X-
17873886Structural determinants of RNA recognition and cleavage by Dicer.Nat Struct Mol Biol2007 OctMacRae IJ-
17360756Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production.J Virol2007 MayChristensen HS-
23658827Distinguishable in vitro binding mode of monomeric TRBP and dimeric PACT with siRNA.PLoS One2013 May 2Takahashi Tdoi: 10.1371/journal.pone.0063434
23728176MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.J Clin Invest2013 JunNemlich Y-
27012177Visualizing repetitive diffusion activity of double-strand RNA binding proteins by single molecule fluorescence assays.Methods2016 Aug 1Koh HRdoi: 10.1016/j.ymeth.2016.03.009
28665774New DRB complexes for new DRB functions in plants.RNA Biol2017 Dec 2Montavon Tdoi: 10.1080/15476286.2017.1343787
31098005Tetracyclines as Inhibitors of Pre-microRNA Maturation: A Disconnection between RNA Binding and Inhibition.ACS Med Chem Lett2019 Apr 22Garner ALdoi: 10.1021/acsmedchemlett.9b00091
23066106RNA-binding protein AUF1 represses Dicer expression.Nucleic Acids Res2012 DecAbdelmohsen Kdoi: 10.1093/nar/gks930
25557550Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis.Mol Cell2015 Feb 5Wilson RCdoi: 10.1016/j.molcel.2014.11.030
12411504Ribonuclease activity and RNA binding of recombinant human Dicer.EMBO J2002 Nov 1Provost P-
16271387Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.Cell2005 Nov 18Gregory RI-
16142218TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing.EMBO Rep2005 OctHaase AD-
16085484MicroRNAs: Loquacious speaks out.Curr Biol2005 Aug 9Leuschner PJ-
15774722MicroRNAs regulate brain morphogenesis in zebrafish.Science2005 May 6Giraldez AJ-
15314213Arabidopsis micro-RNA biogenesis through Dicer-like 1 protein functions.Proc Natl Acad Sci U S A2004 Aug 24Kurihara Y-
15242644Single processing center models for human Dicer and bacterial RNase III.Cell2004 Jul 9Zhang H-
15152257Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.Nature2004 May 20Ma JBdoi: 10.1038/nature02519.
20152181Nuclear retention of fission yeast dicer is a prerequisite for RNAi-mediated heterochromatin assembly.Dev Cell2010 Jan 19Emmerth Sdoi: 10.1016/j.devcel.2009.11.011.
20116247MicroRNA function is globally suppressed in mouse oocytes and early embryos.Curr Biol2010 Feb 9Suh Ndoi: 10.1016/j.cub.2009.12.044
19802599Processing of miRNA precursors.Methods Mol Biol2010Kurihara Ydoi: 10.1007/978-1-60327-005-2_15.
22961479Expression of microRNA machinery proteins in different types of chronic rhinosinusitis.Laryngoscope2012 DecZhang YNdoi: 10.1002/lary.23517
18508075Autoinhibition of human dicer by its internal helicase domain.J Mol Biol2008 Jun 27Ma Edoi: 10.1016/j.jmb.2008.05.005
18363798Mini-III, an unusual member of the RNase III family of enzymes, catalyses 23S ribosomal RNA maturation in B. subtilis.Mol Microbiol2008 JunRedko Ydoi: 10.1111/j.1365-2958.2008.06207.x
18366743The evolution of core proteins involved in microRNA biogenesis.BMC Evol Biol2008 Mar 25Murphy Ddoi: 10.1186/1471-2148-8-92.
17666393Functional anatomy of the Drosophila microRNA-generating enzyme.J Biol Chem2007 Sep 28Ye X-
17320391The miRNA pathway intrinsically controls self-renewal of Drosophila germline stem cells.Curr Biol2007 Mar 20Park JK-
17277330SCOOP: a simple method for identification of novel protein superfamily relationships.Bioinformatics2007 Apr 1Bateman A-
16954143DUF283 domain of Dicer proteins has a double-stranded RNA-binding fold.Bioinformatics2006 Nov 15Dlakic M-
22002349Backbone and sidechain methyl Ile (delta1), Leu and Val chemical shift assignments of RDE-4 (1-243), an RNA interference initiation protein in C. elegans.Biomol NMR Assign2012 OctChiliveri SCdoi: 10.1007/s12104-011-9343-0
21815640A LIN28-dependent structural change in pre-let-7g directly inhibits dicer processing.Biochemistry2011 Sep 6Lightfoot HLdoi: 10.1021/bi200851d
21726814siRNA repositioning for guide strand selection by human Dicer complexes.Mol Cell2011 Jul 8Noland CLdoi: 10.1016/j.molcel.2011.05.028.
21501829The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response.Cell Host Microbe2011 Apr 21Kok KHdoi: 10.1016/j.chom.2011.03.007.
21273303A microRNA expression signature of osteoclastogenesis.Blood2011 Mar 31Sugatani Tdoi: 10.1182/blood-2010-10-311415
23180579Evolution of animal and plant dicers: early parallel duplications and recurrent adaptation of antiviral RNA binding in plants.Mol Biol Evol2013 MarMukherjee Kdoi: 10.1093/molbev/mss263
23194006Second double-stranded RNA binding domain of dicer-like ribonuclease 1: structural and biochemical characterization.Biochemistry2012 Dec 21Burdisso Pdoi: 10.1021/bi301247r
25409478Structural determinants of Arabidopsis thaliana Hyponastic leaves 1 function in vivo.PLoS One2014 Nov 19Burdisso Pdoi: 10.1371/journal.pone.0113243
25378324Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells.Nucleic Acids Res2015 JanRoos Mdoi: 10.1093/nar/gku1090
25135636Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing.J Biol Chem2014 Oct 10Kidwell MAdoi: 10.1074/jbc.M114.589051
25110015Regulation of miRNA strand selection: follow the leader?Biochem Soc Trans2014 AugMeijer HAdoi: 10.1042/BST20140142.
26769856Structural and functional insights into the fly microRNA biogenesis factor Loquacious.RNA2016 MarJakob Ldoi: 10.1261/rna.055426.115
24563462Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein.J Biol Chem2014 Apr 4Zimmermann Jdoi: 10.1074/jbc.M114.557066
24030553The evolution of microRNA pathway protein components in Cnidaria.Mol Biol Evol2013 DecMoran Ydoi: 10.1093/molbev/mst159
23882114The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal.RNA2013 SepDoyle Mdoi: 10.1261/rna.039255.113
23791529DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway.Cell Rep2013 Jun 27Wan Gdoi: 10.1016/j.celrep.2013.05.038
23511973The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing.EMBO J2013 Apr 17Stalder Ldoi: 10.1038/emboj.2013.52
26833131Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.Sci Rep2016 Feb 2Kim YSdoi: 10.1038/srep20242.
27045313Revealing a new activity of the human Dicer DUF283 domain in vitro.Sci Rep2016 Apr 5Kurzynska-Kokorniak Adoi: 10.1038/srep23989.
26990999Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence.Aging Cell2016 JunNoren Hooten Ndoi: 10.1111/acel.12469
26230096A Single RNaseIII Domain Protein from Entamoeba histolytica Has dsRNA Cleavage Activity and Can Help Mediate RNAi Gene Silencing in a Heterologous System.PLoS One2015 Jul 31Pompey JMdoi: 10.1371/journal.pone.0133740
26012717Morphine Promotes Astrocyte-Preferential Differentiation of Mouse Hippocampal Progenitor Cells via PKC-epsilon-Dependent ERK Activation and TRBP Phosphorylation.Stem Cells2015 SepXu Cdoi: 10.1002/stem.2055
25977444The polymorphic terminal-loop of pre-miR-1307 binding with MBNL1 contributes to colorectal carcinogenesis via interference with Dicer1 recruitment.Carcinogenesis2015 AugTang Rdoi: 10.1093/carcin/bgv066
28827780RNA interference in the Asian Longhorned Beetle:Identification of Key RNAi Genes and Reference Genes for RT-qPCR.Sci Rep2017 Aug 21Rodrigues TBdoi: 10.1038/s41598-017-08813-1.
29042235Splicing factors as regulators of miRNA biogenesis - links to human disease.Semin Cell Dev Biol2018 JulRatnadiwakara Mdoi: 10.1016/j.semcdb.2017.10.008
29045748Conserved asymmetry underpins homodimerization of Dicer-associated double-stranded RNA-binding proteins.Nucleic Acids Res2017 Dec 1Heyam Adoi: 10.1093/nar/gkx928.
29579397Dicer1 Deficiency in the Idiopathic Pulmonary Fibrosis Fibroblastic Focus Promotes Fibrosis by Suppressing MicroRNA Biogenesis.Am J Respir Crit Care Med2018 Aug 15Herrera Jdoi: 10.1164/rccm.201709-1823OC.
29599909RNA-binding protein AUF1 suppresses miR-122 biogenesis by down-regulating Dicer1 in hepatocellular carcinoma.Oncotarget2018 Jan 9Wu Xdoi: 10.18632/oncotarget.24079
29657270TWEAK Negatively Regulates Human Dicer.Noncoding RNA2016 Oct 25Lambert Mdoi: 10.3390/ncrna2040012.
30626973FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing.Nature2019 JanRingeard Mdoi: 10.1038/s41586-018-0841-4
28753441RNAi-mediated resistance to viruses: a critical assessment of methodologies.Curr Opin Virol2017 OctPooggin MMdoi: 10.1016/j.coviro.2017.07.010
16177131ATP modulates siRNA interactions with an endogenous human Dicer complex.RNA2005 NovPellino JL-
30682089HIV-1 infection increases microRNAs that inhibit Dicer1, HRB and HIV-EP2, thereby reducing viral replication.PLoS One2019 Jan 25Modai Sdoi: 10.1371/journal.pone.0211111
19022417Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.Biochim Biophys Acta2009 FebDincbas-Renqvist Vdoi: 10.1016/j.bbagrm.2008.10.002
16603715RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA.RNA2006 MayParker GS-
18948111dsRNA binding properties of RDE-4 and TRBP reflect their distinct roles in RNAi.J Mol Biol2008 Dec 26Parker GSdoi: 10.1016/j.jmb.2008.10.002
20217543Current knowledge of MicroRNAs and noncoding RNAs in virus-infected cells.Methods Mol Biol2010Ouellet DLdoi: 10.1007/978-1-60761-588-0_3.
24878341Parts, assembly and operation of the RIG-I family of motors.Curr Opin Struct Biol2014 AprRawling DCdoi: 10.1016/j.sbi.2013.11.011
24787225A universal small molecule, inorganic phosphate, restricts the substrate specificity of Dicer-2 in small RNA biogenesis.Cell Cycle2014Fukunaga Rdoi: 10.4161/cc.29066
26926528Multistrand Structure Prediction of Nucleic Acid Assemblies and Design of RNA Switches.Nano Lett2016 Mar 9Bindewald Edoi: 10.1021/acs.nanolett.5b04651
26425937Structures and Energetics of Four Adjacent G.U Pairs That Stabilize an RNA Helix.J Phys Chem B2015 Oct 22Gu Xdoi: 10.1021/acs.jpcb.5b06970
27980061-----
28180322A specific dsRNA-binding protein complex selectively sequesters endogenous inverted-repeat siRNA precursors and inhibits their processing.Nucleic Acids Res2017 Feb 17Montavon Tdoi: 10.1093/nar/gkw1264.
19017633Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.J Biol Chem2009 Jan 23Lima WFdoi: 10.1074/jbc.M803748200
26074074Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.Cell Rep2015 Jun 23Gelfand BDdoi: 10.1016/j.celrep.2015.05.023
11835276Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression.Bioessays2002 FebBanerjee D-
15542639Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis.J Virol2004 DecLu S-
20179251Expansion of the miRNA pathway in the hemipteran insect Acyrthosiphon pisum.Mol Biol Evol2010 MayJaubert-Possamai Sdoi: 10.1093/molbev/msp256
19127773[Dicer interacts with Wig-1 protein].Fen Zi Xi Bao Sheng Wu Xue Bao2008 OctHuang J-
19073568[Progress of studies on Dicer structure and function].Yi Chuan2008 DecPeng JJ-
18023283In vitro binding of single-stranded RNA by human Dicer.FEBS Lett2007 Dec 11Kini HK-
22004415Selection of RNA oligonucleotides that can modulate human dicer activity in vitro.Nucleic Acid Ther2011 OctTyczewska Adoi: 10.1089/nat.2011.0304.
21984186Two classes of silencing RNAs move between Caenorhabditis elegans tissues.Nat Struct Mol Biol2011 Oct 9Jose AMdoi: 10.1038/nsmb.2134.
21297638Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels.Nat Struct Mol Biol2011 MarBennasser Ydoi: 10.1038/nsmb.1987
21146518C. elegans Dicer interacts with the P-granule component GLH-1 and both regulate germline RNPs.Dev Biol2011 Feb 15Beshore ELdoi: 10.1016/j.ydbio.2010.12.005
20974746Short RNA duplexes guide sequence-dependent cleavage by human Dicer.RNA2010 DecBergeron L Jrdoi: 10.1261/rna.2346510
25490268A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans.Dev Cell2014 Dec 8Drake Mdoi: 10.1016/j.devcel.2014.11.004.
25281003Chemical shift assignments of DRB4 (1-153), a dsRNA binding protein in A. thaliana RNAi pathway.Biomol NMR Assign2015 OctChiliveri SCdoi: 10.1007/s12104-014-9585-8
27872309Phosphate-binding pocket in Dicer-2 PAZ domain for high-fidelity siRNA production.Proc Natl Acad Sci U S A2016 Dec 6Kandasamy SK-
24359019Targeting the production of oncogenic microRNAs with multimodal synthetic small molecules.ACS Chem Biol2014 Mar 21Vo DDdoi: 10.1021/cb400668h
24142921Identification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiation.G3 (Bethesda)2013 Dec 9Wolf Ldoi: 10.1534/g3.113.008698.
24065110Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides.Eur J Hum Genet2014 AprSabbaghian Ndoi: 10.1038/ejhg.2013.215
23435228The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains.Nucleic Acids Res2013 AprBenoit MPdoi: 10.1093/nar/gkt086
27560640Progress in micro RNA focused research in endocrinology.Endocr Regul2016 AprVoglova Kdoi: 10.1515/enr-2016-0012.
26764378Arabidopsis RNASE THREE LIKE2 Modulates the Expression of Protein-Coding Genes via 24-Nucleotide Small Interfering RNA-Directed DNA Methylation.Plant Cell2016 FebElvira-Matelot Edoi: 10.1105/tpc.15.00540
26033159Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis.J Pathol2015 OctChen Jdoi: 10.1002/path.4569
28779324Switches in Dicer Activity During Oogenesis and Early Development.Results Probl Cell Differ2017Lim MYTdoi: 10.1007/978-3-319-60855-6_14.
28874570Loquacious-PD facilitates Drosophila Dicer-2 cleavage through interactions with the helicase domain and dsRNA.Proc Natl Acad Sci U S A2017 Sep 19Trettin KDdoi: 10.1073/pnas.1707063114
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000527554DICER1-206665--- (aa)--
ENST00000526495DICER1-20310331XM_011536599ENSP000004372561922 (aa)XP_011534901Q9UPY3
ENST00000529720DICER1-208498-ENSP0000043392670 (aa)-Q5D0K5
ENST00000529206DICER1-2071286--- (aa)--
ENST00000393063DICER1-20210220XM_011536601ENSP000003767831922 (aa)XP_011534903Q9UPY3
ENST00000556045DICER1-2142776-ENSP00000451041820 (aa)-Q9UPY3
ENST00000556681DICER1-215310--- (aa)--
ENST00000527414DICER1-2046179XM_011536604ENSP000004356811922 (aa)XP_011534906Q9UPY3
ENST00000343455DICER1-20110277XM_011536605ENSP000003437451922 (aa)XP_011534907Q9UPY3
ENST00000527416DICER1-205691--- (aa)--
ENST00000541352DICER1-2125621-ENSP000004447191829 (aa)-Q9UPY3
ENST00000554367DICER1-213897--- (aa)--
ENST00000532939DICER1-2111609-ENSP00000452556394 (aa)-H0YJZ6
ENST00000531162DICER1-209607-ENSP0000043306070 (aa)-Q5D0K5
ENST00000532458DICER1-210591--- (aa)--
Gene Model
Click here to download ENSG00000100697's gene model file
Pathways
Pathway IDPathway NameSource
hsa05206MicroRNAs in cancerKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000100697Platelet Function Tests5.3900000E-006-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000100697rs558742971495127620GHeel bone mineral density28869591[0.027-0.05] unit increase0.0384349EFO_0009270
ENSG00000100697rs558742971495127620GHeel bone mineral density28869591[0.026-0.059] unit increase0.0426014EFO_0009270
ENSG00000100697rs558742971495127620?Heel bone mineral density30048462[0.019-0.034] unit increase0.0264271EFO_0009270
ENSG00000100697rs19535351495129942?Heel bone mineral density30048462[0.019-0.034] unit increase0.0265895EFO_0009270
ENSG00000100697rs71469831495144541THeel bone mineral density30598549[0.022-0.035] unit decrease0.0286057EFO_0009270
ENSG00000100697rs19535351495129942?Heel bone mineral density30595370EFO_0009270
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000100697's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000100697DICER18695.000ENSAPOG00000020381dicer110077.094Acanthochromis_polyacanthus
ENSG00000100697DICER110097.143ENSAMEG00000006447DICER110096.724Ailuropoda_melanoleuca
ENSG00000100697DICER18693.333ENSACIG00000000890dicer19976.641Amphilophus_citrinellus
ENSG00000100697DICER18695.000ENSAOCG00000023381dicer110076.789Amphiprion_ocellaris
ENSG00000100697DICER18695.000ENSAPEG00000022809dicer110076.636Amphiprion_percula
ENSG00000100697DICER18695.000ENSATEG00000014048dicer110076.378Anabas_testudineus
ENSG00000100697DICER110098.571ENSAPLG00000012407DICER110092.168Anas_platyrhynchos
ENSG00000100697DICER110097.143ENSACAG00000013033DICER110089.386Anolis_carolinensis
ENSG00000100697DICER1100100.000ENSANAG00000023622DICER110099.272Aotus_nancymaae
ENSG00000100697DICER18693.333ENSACLG00000007920dicer110076.615Astatotilapia_calliptera
ENSG00000100697DICER18696.667ENSAMXG00000010730dicer110078.597Astyanax_mexicanus
ENSG00000100697DICER1100100.000ENSBTAG00000012852DICER110096.360Bos_taurus
ENSG00000100697DICER18253.906WBGene00000939dcr-18053.906Caenorhabditis_elegans
ENSG00000100697DICER1100100.000ENSCJAG00000006225DICER110099.063Callithrix_jacchus
ENSG00000100697DICER1100100.000ENSCAFG00000017701DICER110097.088Canis_familiaris
ENSG00000100697DICER1100100.000ENSCAFG00020014247DICER110097.088Canis_lupus_dingo
ENSG00000100697DICER1100100.000ENSCHIG00000015885DICER110095.996Capra_hircus
ENSG00000100697DICER110098.571ENSTSYG00000002044DICER110088.214Carlito_syrichta
ENSG00000100697DICER19991.961ENSCAPG00000000101DICER19892.017Cavia_aperea
ENSG00000100697DICER1100100.000ENSCPOG00000004221DICER110095.944Cavia_porcellus
ENSG00000100697DICER1100100.000ENSCCAG00000027063DICER110099.168Cebus_capucinus
ENSG00000100697DICER1100100.000ENSCATG00000031403DICER110099.324Cercocebus_atys
ENSG00000100697DICER1100100.000ENSCLAG00000015000DICER110096.724Chinchilla_lanigera
ENSG00000100697DICER1100100.000ENSCSAG00000010696DICER110099.272Chlorocebus_sabaeus
ENSG00000100697DICER1100100.000ENSCHOG00000002136DICER19093.346Choloepus_hoffmanni
ENSG00000100697DICER110098.571ENSCPBG00000009859DICER110094.973Chrysemys_picta_bellii
ENSG00000100697DICER19641.503ENSCING00000008383-9944.184Ciona_intestinalis
ENSG00000100697DICER15579.592ENSCSAVG00000006137-8679.592Ciona_savignyi
ENSG00000100697DICER1100100.000ENSCANG00000031429DICER110099.272Colobus_angolensis_palliatus
ENSG00000100697DICER1100100.000ENSCGRG00001008088Dicer110094.176Cricetulus_griseus_chok1gshd
ENSG00000100697DICER1100100.000ENSCGRG00000012281Dicer110094.176Cricetulus_griseus_crigri
ENSG00000100697DICER18695.000ENSCSEG00000017078dicer110076.319Cynoglossus_semilaevis
ENSG00000100697DICER18691.667ENSCVAG00000020035dicer19976.431Cyprinodon_variegatus
ENSG00000100697DICER18696.667ENSDARG00000001129dicer110079.128Danio_rerio
ENSG00000100697DICER1100100.000ENSDNOG00000004190DICER110093.337Dasypus_novemcinctus
ENSG00000100697DICER1100100.000ENSDORG00000006215Dicer110093.922Dipodomys_ordii
ENSG00000100697DICER18163.918FBgn0039016Dcr-17063.918Drosophila_melanogaster
ENSG00000100697DICER19196.018ENSETEG00000011000DICER110097.309Echinops_telfairi
ENSG00000100697DICER18770.492ENSEBUG00000013802dicer19163.306Eptatretus_burgeri
ENSG00000100697DICER1100100.000ENSEASG00005021485DICER110095.892Equus_asinus_asinus
ENSG00000100697DICER1100100.000ENSECAG00000006079DICER110099.144Equus_caballus
ENSG00000100697DICER19096.825ENSEEUG00000003893-5597.761Erinaceus_europaeus
ENSG00000100697DICER18693.333ENSELUG00000024317dicer110075.629Esox_lucius
ENSG00000100697DICER19997.101ENSFCAG00000003535DICER19995.682Felis_catus
ENSG00000100697DICER110098.571ENSFALG00000002516DICER110092.096Ficedula_albicollis
ENSG00000100697DICER1100100.000ENSFDAG00000021287DICER110096.516Fukomys_damarensis
ENSG00000100697DICER18691.667ENSFHEG00000016839dicer19973.117Fundulus_heteroclitus
ENSG00000100697DICER18695.000ENSGMOG00000006057dicer18983.515Gadus_morhua
ENSG00000100697DICER110098.571ENSGALG00000010999DICER19998.264Gallus_gallus
ENSG00000100697DICER18691.667ENSGAFG00000010728dicer19976.717Gambusia_affinis
ENSG00000100697DICER18693.333ENSGACG00000020134dicer19976.240Gasterosteus_aculeatus
ENSG00000100697DICER19987.073ENSGAGG00000016379DICER19990.879Gopherus_agassizii
ENSG00000100697DICER1100100.000ENSGGOG00000003760DICER110099.948Gorilla_gorilla
ENSG00000100697DICER18693.333ENSHBUG00000018941dicer110076.769Haplochromis_burtoni
ENSG00000100697DICER1100100.000ENSHGLG00000018124DICER110096.516Heterocephalus_glaber_female
ENSG00000100697DICER1100100.000ENSHGLG00100010985DICER110096.516Heterocephalus_glaber_male
ENSG00000100697DICER18693.333ENSHCOG00000015738dicer110076.114Hippocampus_comes
ENSG00000100697DICER18696.667ENSIPUG00000005080dicer110076.571Ictalurus_punctatus
ENSG00000100697DICER19996.654ENSSTOG00000022439DICER110096.654Ictidomys_tridecemlineatus
ENSG00000100697DICER110098.571ENSJJAG00000010766Dicer110093.139Jaculus_jaculus
ENSG00000100697DICER18996.413ENSKMAG00000001429dicer110096.413Kryptolebias_marmoratus
ENSG00000100697DICER18695.000ENSLBEG00000008928dicer110075.699Labrus_bergylta
ENSG00000100697DICER110091.429ENSLACG00000008302DICER110084.847Latimeria_chalumnae
ENSG00000100697DICER19495.455ENSLOCG00000008544dicer19981.644Lepisosteus_oculatus
ENSG00000100697DICER19996.658ENSLAFG00000013632DICER110096.658Loxodonta_africana
ENSG00000100697DICER1100100.000ENSMFAG00000002987DICER110099.376Macaca_fascicularis
ENSG00000100697DICER1100100.000ENSMMUG00000023305DICER110099.376Macaca_mulatta
ENSG00000100697DICER1100100.000ENSMNEG00000021073DICER110099.324Macaca_nemestrina
ENSG00000100697DICER1100100.000ENSMLEG00000034800DICER110099.324Mandrillus_leucophaeus
ENSG00000100697DICER18693.333ENSMAMG00000016806dicer110077.447Mastacembelus_armatus
ENSG00000100697DICER18693.333ENSMZEG00005016989dicer110076.615Maylandia_zebra
ENSG00000100697DICER110098.571ENSMGAG00000013207DICER110091.848Meleagris_gallopavo
ENSG00000100697DICER1100100.000ENSMAUG00000009936Dicer110094.072Mesocricetus_auratus
ENSG00000100697DICER1100100.000ENSMICG00000011690DICER110097.920Microcebus_murinus
ENSG00000100697DICER1100100.000ENSMOCG00000018636Dicer110094.384Microtus_ochrogaster
ENSG00000100697DICER18695.000ENSMMOG00000018531dicer110076.398Mola_mola
ENSG00000100697DICER110098.571ENSMODG00000012624DICER110093.094Monodelphis_domestica
ENSG00000100697DICER18695.000ENSMALG00000009445dicer110077.077Monopterus_albus
ENSG00000100697DICER19992.891ENSMUSG00000041415Dicer110092.734Mus_musculus
ENSG00000100697DICER19996.445ENSMPUG00000003130DICER110096.445Mustela_putorius_furo
ENSG00000100697DICER110098.571ENSMLUG00000003991DICER110094.805Myotis_lucifugus
ENSG00000100697DICER1100100.000ENSNGAG00000010103Dicer110093.812Nannospalax_galili
ENSG00000100697DICER19875.316ENSNBRG00000022306dicer19775.000Neolamprologus_brichardi
ENSG00000100697DICER1100100.000ENSNLEG00000017309DICER110099.688Nomascus_leucogenys
ENSG00000100697DICER17298.701ENSMEUG00000000614-7798.701Notamacropus_eugenii
ENSG00000100697DICER19696.970ENSOPRG00000014698DICER19696.970Ochotona_princeps
ENSG00000100697DICER110098.571ENSODEG00000008594DICER110096.419Octodon_degus
ENSG00000100697DICER18791.803ENSONIG00000010424dicer19977.538Oreochromis_niloticus
ENSG00000100697DICER110098.571ENSOANG00000012034DICER110091.732Ornithorhynchus_anatinus
ENSG00000100697DICER110098.571ENSOCUG00000010849DICER110092.387Oryctolagus_cuniculus
ENSG00000100697DICER18695.000ENSORLG00000011022dicer19880.348Oryzias_latipes
ENSG00000100697DICER18695.000ENSORLG00020021795dicer19880.522Oryzias_latipes_hni
ENSG00000100697DICER18695.000ENSORLG00015019667dicer110076.225Oryzias_latipes_hsok
ENSG00000100697DICER18695.000ENSOMEG00000018679dicer110076.562Oryzias_melastigma
ENSG00000100697DICER1100100.000ENSOGAG00000010719DICER110096.894Otolemur_garnettii
ENSG00000100697DICER1100100.000ENSOARG00000015465DICER110095.892Ovis_aries
ENSG00000100697DICER110099.896ENSPPAG00000035143DICER110099.896Pan_paniscus
ENSG00000100697DICER19995.521ENSPPRG00000001322DICER19995.521Panthera_pardus
ENSG00000100697DICER19698.507ENSPTIG00000008215DICER19995.417Panthera_tigris_altaica
ENSG00000100697DICER110099.896ENSPTRG00000023484DICER110099.896Pan_troglodytes
ENSG00000100697DICER1100100.000ENSPANG00000023078DICER110099.376Papio_anubis
ENSG00000100697DICER110084.286ENSPKIG00000019962dicer19977.944Paramormyrops_kingsleyae
ENSG00000100697DICER110097.143ENSPSIG00000010801DICER110090.796Pelodiscus_sinensis
ENSG00000100697DICER18695.000ENSPMGG00000010210dicer110077.306Periophthalmus_magnuspinnatus
ENSG00000100697DICER1100100.000ENSPEMG00000014125Dicer110094.072Peromyscus_maniculatus_bairdii
ENSG00000100697DICER1100100.000ENSPCIG00000018004DICER110093.195Phascolarctos_cinereus
ENSG00000100697DICER18691.667ENSPFOG00000008531dicer19976.613Poecilia_formosa
ENSG00000100697DICER18691.667ENSPLAG00000008539dicer19976.458Poecilia_latipinna
ENSG00000100697DICER18691.667ENSPMEG00000014284dicer19976.571Poecilia_mexicana
ENSG00000100697DICER18690.000ENSPREG00000012120dicer19976.455Poecilia_reticulata
ENSG00000100697DICER1100100.000ENSPPYG00000006112DICER110099.740Pongo_abelii
ENSG00000100697DICER19798.529ENSPCAG00000010828DICER18594.539Procavia_capensis
ENSG00000100697DICER1100100.000ENSPCOG00000022909DICER110097.868Propithecus_coquereli
ENSG00000100697DICER19888.693ENSPVAG00000004811DICER110088.747Pteropus_vampyrus
ENSG00000100697DICER18693.333ENSPNYG00000017939dicer110076.718Pundamilia_nyererei
ENSG00000100697DICER18696.667ENSPNAG00000001012dicer110079.627Pygocentrus_nattereri
ENSG00000100697DICER1100100.000ENSRNOG00000010711Dicer110093.136Rattus_norvegicus
ENSG00000100697DICER1100100.000ENSRBIG00000020932DICER110099.324Rhinopithecus_bieti
ENSG00000100697DICER1100100.000ENSRROG00000031891DICER110099.376Rhinopithecus_roxellana
ENSG00000100697DICER1100100.000ENSSBOG00000028660DICER110099.272Saimiri_boliviensis_boliviensis
ENSG00000100697DICER1100100.000ENSSHAG00000012077DICER110093.143Sarcophilus_harrisii
ENSG00000100697DICER110080.000ENSSFOG00015010804dicer19984.211Scleropages_formosus
ENSG00000100697DICER18695.000ENSSMAG00000015520dicer110076.498Scophthalmus_maximus
ENSG00000100697DICER18695.000ENSSDUG00000021652dicer110077.112Seriola_dumerili
ENSG00000100697DICER18695.000ENSSLDG00000012087dicer110074.560Seriola_lalandi_dorsalis
ENSG00000100697DICER19492.424ENSSARG00000000219-6291.781Sorex_araneus
ENSG00000100697DICER110098.571ENSSPUG00000016222DICER110092.096Sphenodon_punctatus
ENSG00000100697DICER18695.000ENSSPAG00000017128dicer110076.173Stegastes_partitus
ENSG00000100697DICER1100100.000ENSSSCG00000028225DICER110093.652Sus_scrofa
ENSG00000100697DICER110097.143ENSTGUG00000012658DICER110091.992Taeniopygia_guttata
ENSG00000100697DICER18693.333ENSTRUG00000006156dicer19975.780Takifugu_rubripes
ENSG00000100697DICER19686.765ENSTNIG00000005441dicer19975.806Tetraodon_nigroviridis
ENSG00000100697DICER19592.042ENSTBEG00000012374DICER110089.511Tupaia_belangeri
ENSG00000100697DICER1100100.000ENSTTRG00000013044DICER19498.807Tursiops_truncatus
ENSG00000100697DICER110097.143ENSUAMG00000011912DICER19996.576Ursus_americanus
ENSG00000100697DICER110097.143ENSUMAG00000003027DICER110095.996Ursus_maritimus
ENSG00000100697DICER1100100.000ENSVPAG00000006817DICER19594.004Vicugna_pacos
ENSG00000100697DICER1100100.000ENSVVUG00000018855DICER110097.140Vulpes_vulpes
ENSG00000100697DICER19396.923ENSXETG00000023315dicer19983.082Xenopus_tropicalis
ENSG00000100697DICER19295.982ENSXCOG00000009353dicer19995.982Xiphophorus_couchianus
ENSG00000100697DICER18691.667ENSXMAG00000015721dicer19976.756Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II-ISSProcess
GO:0003677DNA binding-IEAFunction
GO:0003725double-stranded RNA binding12411504.IDAFunction
GO:0003725double-stranded RNA binding19701182.IMPFunction
GO:0004386helicase activity-IEAFunction
GO:0004521endoribonuclease activity25549615.IDAFunction
GO:0004521endoribonuclease activity18325616.19701182.IMPFunction
GO:0004521endoribonuclease activity19820710.TASFunction
GO:0004525ribonuclease III activity11201747.11452083.12411504.12411505.EXPFunction
GO:0004525ribonuclease III activity21873635.IBAFunction
GO:0004525ribonuclease III activity21753850.IDAFunction
GO:0004530deoxyribonuclease I activity21873635.IBAFunction
GO:0005515protein binding12526743.14749716.15973356.16142218.16424907.17452327.17507929.17531811.17932509.18325616.19716330.19804757.19820710.20869963.21858095.21903422.23622242.23661684.23741051.25446899.25557550.26496610.28546213.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005793endoplasmic reticulum-Golgi intermediate compartment-IEAComponent
GO:0005829cytosol-TASComponent
GO:0006309apoptotic DNA fragmentation21873635.IBAProcess
GO:0010586miRNA metabolic process-TASProcess
GO:0010626negative regulation of Schwann cell proliferation-ISSProcess
GO:0014040positive regulation of Schwann cell differentiation-ISSProcess
GO:0016442RISC complex21873635.IBAComponent
GO:0016442RISC complex16357216.IDAComponent
GO:0019904protein domain specific binding12526743.IPIFunction
GO:0021675nerve development-ISSProcess
GO:0030422production of siRNA involved in RNA interference21873635.IBAProcess
GO:0030422production of siRNA involved in RNA interference15973356.17452327.23661684.IDAProcess
GO:0030422production of siRNA involved in RNA interference-TASProcess
GO:0030423targeting of mRNA for destruction involved in RNA interference15973356.17452327.IMPProcess
GO:0030425dendrite-IEAComponent
GO:0030426growth cone-IEAComponent
GO:0031054pre-miRNA processing21873635.IBAProcess
GO:0031054pre-miRNA processing15973356.16357216.18178619.23661684.25549615.IDAProcess
GO:0031643positive regulation of myelination-ISSProcess
GO:0032290peripheral nervous system myelin formation-ISSProcess
GO:0032720negative regulation of tumor necrosis factor production26435691.IMPProcess
GO:0033167ARC complex19701182.ICComponent
GO:0033168conversion of ds siRNA to ss siRNA involved in RNA interference19701182.IMPProcess
GO:0035068micro-ribonucleoprotein complex17531811.IDAComponent
GO:0035087siRNA loading onto RISC involved in RNA interference15973356.IDAProcess
GO:0035196production of miRNAs involved in gene silencing by miRNA15973356.23661684.IDAProcess
GO:0035196production of miRNAs involved in gene silencing by miRNA26435691.IMPProcess
GO:0035196production of miRNAs involved in gene silencing by miRNA-ISSProcess
GO:0035197siRNA binding15973356.IDAFunction
GO:0035280miRNA loading onto RISC involved in gene silencing by miRNA18178619.IDAProcess
GO:0036404conversion of ds siRNA to ss siRNA18325616.IMPProcess
GO:0038061NIK/NF-kappaB signaling26435691.IDAProcess
GO:0046872metal ion binding-IEAFunction
GO:0048812neuron projection morphogenesis-ISSProcess
GO:0070062extracellular exosome28159509.IDAComponent
GO:0070578RISC-loading complex15973356.16357216.17531811.18178619.19820710.23661684.IDAComponent
GO:0070883pre-miRNA binding18508075.25549615.IDAFunction
GO:0070883pre-miRNA binding18178619.IDAFunction
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic21753850.25549615.IDAProcess
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